Fully Compensated Dynamic Shim System for In Vivo MRI and MRS

Information

  • Research Project
  • 7395060
  • ApplicationId
    7395060
  • Core Project Number
    R41EB008296
  • Full Project Number
    1R41EB008296-01
  • Serial Number
    8296
  • FOA Number
    PA-07-81
  • Sub Project Id
  • Project Start Date
    7/1/2008 - 16 years ago
  • Project End Date
    6/30/2009 - 15 years ago
  • Program Officer Name
    LIU, GUOYING
  • Budget Start Date
    7/1/2008 - 16 years ago
  • Budget End Date
    6/30/2009 - 15 years ago
  • Fiscal Year
    2008
  • Support Year
    1
  • Suffix
  • Award Notice Date
    6/27/2008 - 16 years ago
Organizations

Fully Compensated Dynamic Shim System for In Vivo MRI and MRS

[unreadable] DESCRIPTION (provided by applicant): Functional MRI, diffusion MRI and MR spectroscopy and spectroscopic imaging have great potential for the study and diagnosis of disease and injury, and guiding surgical therapy. All of these methods benefit greatly from the added sensitivity, resolution and contrast from high field strength magnets (3T and above). However, the advantages of higher magnetic fields have not been fully realized due to the increasingly confounding effects of magnetic field inhomogeneity (MFI) caused by magnetic susceptibility differences between air and tissue. MFI leads to signal loss and spatial distortion in MRI and loss in spectral resolution and sensitivity in MRS. The loss of reliability due to these artifacts is a major reason why these techniques have not seen wide use in clinical applications. Current methods of magnetic field homogenization (i.e. shimming) work well on small volumes but are inadequate over larger objects, like the entire human brain. Over the last five years, the MR group at Yale University has developed the technique of dynamic shim updating (DSU) which allows greatly improved magnetic field homogeneity over extended regions. Dynamic shim updating divides a global 3D problem into a number of slices over which adequate magnetic field homogeneity can be achieved. Dynamically updating the pre-determined slice shims in sync with the multi-slice MRI sequence ensures optimal homogeneity for all slices. Given the maturity of the technique, as well as the increasing demand for improved magnetic field homogeneity, it is the goal of this Phase I STTR proposal to develop DSU into a commercially viable method. As all of the previous developments were performed on Yale-specific equipment, the first step towards commercialization is the development, construction and testing of a stand-alone DSU unit. Once the feasibility of the stand- alone DSU unit has been established, the road towards commercialization will be traveled in a future Phase II STTR application. Since MFI affects many facets of in vivo NMR, the successful implementation of DSU will have major impacts on almost all aspects of MRI and MRS and can thus be labeled as highly significant. [unreadable] [unreadable] [unreadable]

IC Name
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
  • Activity
    R41
  • Administering IC
    EB
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    183854
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    286
  • Ed Inst. Type
  • Funding ICs
    NIBIB:183854\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    RESONANCE RESEARCH, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    BILLERICA
  • Organization State
    MA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    018213923
  • Organization District
    UNITED STATES