Functional Architecture of a Histone Deposition Protein

Information

• NSF Award
• 0549131

Owner

• MASSACHUSETTS MEDICAL SCHOOL, UNIVERSITY OF

• Award Id

  0549131

• Award Effective Date

  7/1/2005 - 19 years ago

• Award Expiration Date

  10/31/2007 - 17 years ago

• Award Amount

  $ 293,770.00

• Award Instrument

  Continuing grant

DNA in all organisms exists in large molecules known as chromosomes. In order to fit huge chromosomes into cells, the DNA is compacted by wrapping around chromatin proteins. The major type of chromatin proteins are the histones. This project will focus on Asf1, a protein that binds to histones and delivers them onto DNA during the construction of chromosomes. During the past grant period, it was demonstrated that Asf1 is regulated by proteins that are required for duplicating DNA molecules. These studies will be extended by asking the following questions: Which proteins interact with Asf1? Where on the chromosomes is the Asf1 protein located? How does Asf1 affect the duplication of DNA molecules? Which portions of the Asf1 protein are required for these different activities?

• Program Officer

  Michael K. Reddy

• Min Amd Letter Date

  8/11/2005 - 19 years ago

• Max Amd Letter Date

  7/2/2007 - 17 years ago

• ARRA Amount

• Name

  University of Massachusetts Medical School

• City

  Worcester

• State

  MA

• Country

  United States

• Address

  55 Lake Avenue North

• Postal Code

  016550002

• Phone Number

  5088562119

• First Name

  Paul

• Last Name

  Kaufman

• Email Address

  paul.kaufman1@umassmed.edu

• Start Date

  8/11/2005 12:00:00 AM