Fungicidal mixtures

BACKGROUND OF THE INVENTION

[0001] The present invention relates to a fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent and synergistically effective amounts of

[0002] (a) at least one benzophenone of formula I

[0003] wherein

[0004] R1 represents a halogen atom, an optionally substituted alkyl, alkanoyloxy or alkoxy group; or a hydroxy group,

[0005] R2 represents a halogen atom or an optionally substituted alkyl group, m is 0 or an integer of 1 to 3;

[0006] R3 independently represents a halogen atom, an optionally substituted alkyl or alkoxy group or a nitro group;

[0007] R4 represents a halogen atom, a cyano, carboxy, hydroxy or nitro group or an optionally substituted alkyl, alkoxy, alkenyl, alkylthio, alkylsulphinyl, alkylsulphonyl or amino group;

[0008] R5 represents an optionally substituted alkyl group;

[0009] R6 represents a halogen atom or a nitro group, an optionally substituted alkyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, cycloalkyl, cycloalkyloxy, aryloxy group;

[0010] n is 0 or 1; and

[0011] R7 independently represents a halogen atom, an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, cycloalkyl, cycloalkoxy group;

[0012] (b) at least one fungicidally active ingredient selected from the following groups (A), (B), (C), (D) and (E):

[0013] (A) an ergosterol biosynthesis inhibitor;

[0014] (B) a strobilurine derivative,

[0015] (C) a melanin biosynthesis inhibitor,

[0016] (D) a compound selected from the group consisting of acibenzolar, benomyl, captan, carboxin, chlorothalonil, copper, cyprodinil, dinocap, dithianon, dimethomorph, dodine, ethirimol, famoxadone, fenpiclonil, fluazinam, mancozeb, metalaxyl, pyrifenox, sulfur and vinclozolin, and

[0017] (E) an azolopyrimidine of formula II

[0018] in which

[0019] R8 and R9 each independently represent hydrogen or an optionally substituted alkyl, alkenyl, alkynyl, alkadienyl, aryl, heteroaryl, cycloalkyl, bicycloalkyl or heterocyclyl group, or

[0020] R8 and R9 together with the interjacent nitrogen atom represent an optionally substituted heterocyclic ring,

[0021] R10 represents hydrogen or an alkyl or aryl group,

[0022] R11 represents a hydrogen or halogen atom or an alkyl or alkoxy group,

[0023] L independently represents a halogen atom or an optionally substituted alkyl or alkoxy group,

[0024] A represents N or CR12, wherein R12 has the meaning given for R10, and p is 0 or an integer from 1 to 5.

[0025] The fungicidal compounds of formula I to be used according to the present invention are known for example from U.S. Pat. No. 5,773,663.

[0026] The compounds of the classes (A), (B) and (D) are known from The Pesticide Manual 11th edition 1997, Editor Clive Tomlin.

[0027] The class of melanin biosynthesis inhibitors (MBI) (C) are chemical compounds which are capable of diminishing the in-vivo synthesis of melanin by inhibiting any of the reductase and/or dehydratase enzymes which are responsible for converting tetrahydroxynaphthalene into dihydroxynaphthalene. This class of compounds includes the following known compounds: carpropamid, chlobenthiazione, diclocymet, pyroquilon, phthalide, tricyclazole and certain phenoxyamides, which are known for example from EP 0 262 393, in particular AC 382042 and Japanese patent application JP 5-9165-A.

[0028] The fungicidal compounds of formula II to be used according to the present invention are known for example from U.S. Pat. No. 5,593,996 and from International patent applications WO 98/46607 and WO 98/46608.

[0029] U.S. Pat. No. 5,773,663 suggests to combine fungicidal benzophenone derivatives with other fungicides such as 4,6-dinitro-o-cresol, benalaxyl, benomyl, captafol, captan, carbendazim, chlorothalonil, copper, cymoxanil, dichlofluanid, dichlone, difenoconazole, dimethomorph, diniconzole, dinocap, dithianon, fenpiclonil, fenpropiomorph, hymaxazol, imazalil, iprodione, isoprothiolane, kasugamycin, mancozeb, mepronil, mercuric oxide, oxadixyl, oxolinic acid, penconazole, propineb, pyrifenox, thiabendazole, thiram, tolclofos-methyl, triadimefon, triflumizole, triforine validamycin A, vinclozolin, zineb and ziram.

[0030] However, there is no hint that such mixtures show synergistic effects and can advantageously be used for controlling diseases such as wheat powdery mildew, wheat leaf rust and wheat Septoria leaf blotch, Botrytis diseases and others.

[0031] Surprisingly, a strong synergy between the compounds of formula I and the fungicidally active ingredients selected from the classes (A), (B), (C), (D) and (E) as described above in greenhouse and field trials was found when these two compounds were in-tank mixed and when the activity of these mixtures was compared with that of the solo activity of each active ingredient.

[0032] A mixture of fungicides shows synergistic effect if the fungicidal activity of the mixture is larger than the sum of activities of the separately applied compounds. The expected fungicidal activity for a given mixture of two fungicides can also be calculated as follows (See Colby, S. R., “Calculating synergistic and antagonistic response of herbicide combinations”, Weeds 15, pp 20-22 (1967):

E = X + Y - \frac{XY}{100}

[0033] Wherein

[0034] x is the efficacy in % compared with an untreated control upon treatment with a fungicidal active ingredient A at a dose rate a;

[0035] y is the efficacy in % compared with an untreated control upon treatment with a fungicidal active ingredient B at a dose rate b;

[0036] EE is the expected efficacy with a combination of fungicidal active ingredients A and B at a dose of a+b, respectively.

[0037] If the actual efficacy (E) exceeds the expected (calculated) one (EE), the mixture displays a synergistic effect.

SUMMARY OF THE INVENTION

[0038] (b) The present invention includes a fungicidal composition comprising an acceptable carrier and/or surface active agent and synergistically effective amounts of at least one compound of formula I, and at least one fungicidal active ingredient selected from the following the following groups (A), (B), (C), (D) and (E):

[0039] (A) an ergosterol biosynthesis inhibitor;

[0040] (B) a strobilurine derivative,

[0041] (C) a melanin biosynthesis inhibitor,

[0042] (D) a compound selected from the group consisting of acibenzolar (BION), benomyl, captan, carboxin, chlorothalonil, copper, cyprodinil, dinocap, dithianon, dimethomorph, dodine, ethirimol, famoxadone, fenpiclonil, fluazinam, mancozeb, metalaxyl, pyrifenox, sulfur and vinclozolin, and

[0043] (E) an azolopyrimidine of formula II.

[0044] The present invention also includes a method of controlling the growth of phytopathogenic fungi at a locus which comprises applying synergistically effective amounts of at least one benzophenone of formula I and at least one fungicidally active ingredient selected from the following classes (A), (B), (C), (D) and (E) as defined above to the locus.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0045] Preferred compounds of formula I are benzophenones of formula IA,

[0046] Wherein

[0047] R1 represents a halogen atom, a methyl, trifluoromethyl, methoxy or hydroxy group, in particular a chlorine atom, a methyl or methoxy group;

[0048] R2 represents a halogen atom, in particular a chlorine atom or a methyl group;

[0049] R3 represents a bromine or chlorine atom, a methyl, trifluoromethyl or nitro group, in particular a bromine atom;

[0050] R4 represents a methyl group;

[0051] R5 represents an alkyl group, in particular a methyl group;

[0052] R6 and R7 each independently represent an alkoxy group which may be substituted by a phenyl, alkylphenyl or halophenyl group, preferably C1-6 alkoxy being optionally substituted by a phenyl, methylphenyl or fluorophenyl group, in particular methoxy, benzyloxy and 2-fluorobenzyloxy; and n is 0 or 1.

[0053] Particularly preferred are the benzophenones selected from the group consisting of 6′-butoxy-2,6-dichloro-4′,5′-dimethoxy-2′-methylbenzophenone coded BP-1, 2,6-dichloro-4′,5′-dimethoxy-6′-(2-fluorobenzyloxy)-2′-methylbenzophenone coded BP-2, 6′-benzyloxy-4′,5′-dimethoxy-2,6-dimethyl-2′-methylbenzophenone coded BP-3; 5-bromo-2′,6-dimethyl-2,4′,5′, 6′-tetramethoxybenzophenone coded BP-4 and 2,6-dichloro-2′-methyl-4′,5′, 6′-trimethoxybenzophenone coded BP-5, most preferred is BP-4.

[0054] Preferred ergosterol biosynthesis inhibiotors of group (A) are selected from the group consisting of fenarimol, fenpropimorph, fenpropidine, spiroxamine and triforine.

[0055] Another group of ergosterol biosynthesis inhibiotors are azole derivatives of formulae IIIA and IIIB,

[0056] Wherein

[0057] E represents a linking group selected from the groups (a), (b), (c), (d) and (e):

[0058] In Which

[0059] X1 represents an alkyl or an optionally substituted phenyl group;

[0060] X2 and X3 each independently represent a hydrogen atom or an alkyl group;

[0061] X4 represents an alkyl or cyclopropylalkyl group;

[0062] X5 represents a hydroxy or cyano group;

[0063] X6 represents an optionally substituted phenyl group;

[0064] X7 represents a halogen atom;

[0065] q is 1, 2 or3; and

[0066] r is O or 2;

[0067] wherein X7 and q have the meaning given for formula IIIA, and

[0068] E represents a group of formula —N(X8)-(CH2)s—O—, in which X8 represents a hydrogen atom or an alkyl group and s is an integer from 1 to 6.

[0069] Particularly preferred azole derivatives of group (A) are selected from the group consisting of cyproconazole, epoxiconazole, flusilazole, metconazole, myclobutanil, penconazole, prochloraz, propiconazole, tebuconazole, triadimefon and tridimenol. Most preferred are epoxiconazole, metconazole, myclobutanil and prochloraz.

[0070] Preferred strobilurine derivatives of group (B) are the compounds of formula IV,

[0071] Wherein

[0072] W represents N or CH;

[0073] B represents a —O—, —OCH2—, a —CH2O—, a pyrimid-4,6-dioxydiyl group or a group

[0074] of formula

[0075] R12 represents a C1-4 alkyl group;

[0076] R13 represents a C1-6 alkoxy or a C1-6 alkylamino group;

[0077] R14 represents a hydrogen or halogen atom or a cyano, a C1-4 alkyl or a C1-4 haloalkyl group; and

[0078] s is 0, 1 or 2;

[0079] in particular azoxystrobin, kresoxim methyl, trifloxystrobin or SSF126, most preferred azoxystrobin and kresoxim methyl.

[0080] Preferred melanin inhibitors of group (C) are selected from the group consisting of capropamid, chlobenthiazone, diclocymet, pyroquilon, phthalide, tricyclazole and a phenoxamide coded AC 382042, most preferred is AC 382042.

[0081] Preferred compounds of group (D) are selected from the group consisting of acibenzolar (BION), cyprodinil, dodine, ethirimol, famoxadone, fenpiclonil, fluazinam, mancozeb and metalaxyl.

[0082] Preferred azolopyrimidines of group (E) are the compounds of formula IIA,

[0083] Wherein

[0084] R8 represents a C1-8 alkyl, C2-8 alkenyl, C3-8 cycloalkyl or C1-8 haloalkyl group, in particular a straight-chained or branched C3-6 alkyl, C2-6 alkenyl, C5-6 cycloalkyl or C2-6 fluoroalkyl group, most preferred an isopropyl, 2-butyl, cyclopentyl, methallyl, 2,2,2-trifluoroethyl or 1,1,1-trifluoroprop-2-yl group; and

[0085] R9 represents a hydrogen atom, or a C1-8 alkyl group; most preferred a hydrogen atom or a methyl or ethyl group; or

[0086] R8 and R9 together form an optionally substituted alkylene group having 3 to 6 carbon atoms in the main chain, in which one CH2 group may be replaced by O, S or NH, in particular a piperid-1-yl group being optionally substituted by a C1-6 alkyl group, most preferred a 4-methylpiperid-1-yl group;

[0087] L1, L2 and L3 each independently represent a hydrogen or halogen atom or a C1-4 alkoxy group, at least one of which represents a halogen atom, in particular wherein L1 represents a fluorine atom, L2 represents a hydrogen or fluorine atom or a methoxy group and L3 represents a fluorine or chlorine atom; and

[0088] Hal denotes a halogen atom, in particular a chlorine atom.

[0089] Particularly preferred are the azolopyrimidines of formula II selected from the group consisting of 5-chloro-6-(2-chloro-6-fluorophenyl)-7-(cyclopropylamino)-[1,2,4]triazolo[1,5-a]pyrimidine coded AP-1, 5-chloro-6-(2-chloro-6-fluorophenyl)-7-(4-methylpiperid-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidine coded AP-2, 5-chloro-6-(2-chloro-6-fluorophenyl)-7-(2,2,2-trifluoroethylamino)-[1,2,4]triazolo[1,5-a]pyrimidine coded AP-3 and 5-chloro-6-(2,4,6-trifluorophenyl)-7-[2-(1,1,1-trifluoro)propylamino]-[1,2,4]triazolo[1,5-a]pyrimidine coded AP-4, most preferred is AP-4.

[0090] A particularly preferred embodiment of this invention are compositions of three active ingredients which comprise one compound of formula I and two different compounds selected from the groups (A), (B), (C), (D) and (E), preferably one strobilurine compound selected from group (B) and one ergosterol biosynthesis inhibitor of group (A), in particular kresoxim-methyl and epoxiconazole or kresoxim-methyl and fenpropimorph.

[0091] Another particularly preferred embodiment of the invention are compositions comprising one compound of formula I and two different compounds of group (D), in particular dimethomorph and mancozeb.

[0092] Preferred are co-formulations, comprising the following constituents:

[0093] a carrier;

[0094] at least one benzophenone of formula I,

[0095] at least one compound selected from the classes (A) through (E) as defined above;

[0096] optionally an adjuvant selected from the group consisting of polyalkoxylated alcohols, triglycerides and amines, in particular Synperonic 91-6, which is commercially available from Uniqema, formerly ICI Surfactants;

[0097] optionally a foam breaking agent.

[0098] The compound of formula I and the compound selected from the classes (A) through (E) as defined above are to be applied together, in synergistically effective amounts. These synergistic mixtures exhibit an extraordinary efficacy against a broad range of phytopathogenic fungi, in particular against fungi from the classes ascomycetes, basidiomycetes, oomycetes and deuteromycetes.

[0099] Therefore, they can be applied advantageously against a broad range of diseases in different crops. They may be applied as leaf, stem, root, into-water, seed dressing, nursery box or soil fungicides.

[0100] The mixture according to the invention may be preferably applied for controlling phytopathogenic fungi of the genera: Achlya, Alternaria, Balansia, Bipolaris, Blumeria, Botrytis, Cercospora, Cochliobolus, Curvularia, Cylindrocladium, Drechslera, Entyloma, Erysiphe, Fusarium, Gaeumannomyces, Gerlachia, Gibberella, Guignardia, Leptosphaeria, Magnaporthe, Mucor, Mycosphaerella, Myrothecium, Nigrospora, Peronospora, Phoma, Pseudoperonospora, Pseudocercosporella, Phytophthora, Puccinia, Pyrenophora, Pyricularia, Pythium, Rhizoctonia, Rhizopus, Rhynchosporium, Sarocladium, Sclerophthora, Sclerotium, Septoria, Tilletia, Uncinula, Ustilago, Ustilaginoidea, and Venturia, in particular the species Blumeria graminis f. sp. tritici, Cercospora beticola, Septoria tritici, Erysiphe cichoracearum, Puccinia recondita and Pyrenophora teres.

[0101] The mixtures according to the invention are in particular applied for controlling the above phytopathogenic fungi on monocotylydoneous plants, such as barley and wheat, rice and turf grases or fruit crops such as pomefruits, stonefruits and vines as well as all kinds of vegetables and ornamentals.

[0102] The application rate of the compound of formula I according to this invention is usually in the range of 1 to 2000 grams of active ingredient (g a.i.) per hectare, with rates between 20-500 g a.i./ha often achieving satisfactory control. The optimal rate for a specific application will depend on the crop(s) under cultivation and the predominant species of infesting fungi, and readily may be determined by established biological tests known to those skilled in the art.

[0103] In general, the preferred application rate of the compounds of formula I is in the range of 10 to 500 g a.i./ha, preferably 20-300 g a.i./ha.

[0104] The optimal rate for the compound of group (b) including the classes (A) through (E) will, however, depend on the crop(s) under cultivation and the level of infestation by the fungus, and can readily be determined by established biological tests.

[0105] The ratio (by weight) of the compound of formula I to the fungicidal active ingredient of the classes (A) through (E) as defined above is as a rule, from 100: 1 to 1:100. The preferred ratio formula I:(A) through (E) may vary, e.g., from about 10:1 to about 1:10, in particular from about 5:1 to about 1:5, most preferred from 2:1 to 1:2.

[0106] In the three-ways-compositions according to the present invention, i.e. the compositions containing one compound of formula I and two different compounds selected from the classes (A) through (E), the preferred relative ratios (by weight) are as follows:

[0107] compound of formula I: 200 to 1, preferably 20 to 1

[0108] 1st compound of (A) to (E): 1 to 100, preferably 1 to 10

[0109] 2nd compound of (A) to (E): 1 to 100, preferably 1 to 10.

[0110] The active compounds can be co-formulated together in a suitable ratio according to the present invention, together with usual carriers or diluents and/or additives known in the art.

[0111] Accordingly the invention further provides a fungicidal composition which comprises a carrier and, as active ingredient, at least one compound of formula I as defined above and at least one fungicidal active ingredient selected from the classes (A) through (E) as defined above.

[0112] A method of making such a composition is also provided which comprises bringing the compound of formula I and the fungicidal active ingredient selected from the classes(A) through (E) as defined above into association with at least one carrier. It is also envisaged that different isomers or mixtures of isomers of formula I and/or the fungicidal active ingredient selected from the classes (A) through (E) may have different levels or spectra of activity and thus compositions may comprise individual isomers or mixtures of isomers.

[0113] A composition according to the invention preferably contains from 0.1% to 99.9%, preferably 0.2 to 80% by weight (w/w) of active ingredients.

[0114] A carrier in a composition according to the invention is any material with which the active ingredient is formulated to facilitate application to the locus to be treated, which may for example be a plant, seed, foliage, soil, or into the water where the plant grow, or to the roots or to facilitate storage, transport or handling. A carrier may be a solid or a liquid, including material which is normally a gas but which has been compressed to form a liquid.

[0115] The compositions may be manufactured into e.g. emulsion concentrates, solutions, oil in water emulsions, wettable powders, soluble powders, suspension concentrates, dusts, granules, water dispersible granules, tablets, micro-capsules, gels and other formulation types by well-established procedures. These procedures include intensive mixing and/or milling of the active ingredients with other substances, such as fillers, solvents, solid carriers, surface active compounds (surfactants), and optionally solid and/or liquid auxilaries and/or adjuvants. The form of application such as spraying, atomizing, dispersing or pouring may be chosen like the compositions according to the desired objectives and the given circumstances.

[0116] Solvents may be aromatic hydrocarbons, e.g. Solvesso® 200, substituted naphthalenes, phthalic acid esters, such as dibutyl or dioctyl phthalate, aliphatic hydrocarbons, e.g. cyclohexane or paraffins, alcohols and glycols as well as their ethers and esters, e.g. ethanol, ethyleneglycol mono- and dimethyl ether, ketones such as cyclohexanone, strongly polar solvents such as N-methyl-2-pyrrolidone, or γ-butyrolactone, higher N-alkylpyrrolidones, e.g. N-octylpyrrolidone or N-cyclohexylpyrrolidone, epoxidized plant oil esters, e.g. methylated coconut or soybean oil ester and water. Mixtures of different liquids are often suitable.

[0117] Solid carriers, which may be used for dusts, wettable powders, water dispersible granules, or granules, may be mineral fillers, such as calcite, talc, kaolin, montmorillonite or attapulgite or others. The physical properties may be improved by addition of highly dispersed silica gel or polymers. Carriers for granules may be porous material, e.g. pumice, kaolin, sepiolite, bentonite; non-sorptive carriers may be calcite or sand or others. Additionally, a multitude of pre-granulated inorganic or organic materials may be used, such as dolomite or crushed plant residues.

[0118] Pesticidal compositions are often formulated and transported in a concentrated form which is subsequently diluted by the user before application. The presence of small amounts of a carrier which is a surfactant facilitates this process of dilution. Thus, preferably at least one carrier in a composition according to the invention is a surfactant. For example, the composition may contain at two or more carriers, at least one of which is a surfactant.

[0119] Surfactants may be nonionic, anionic, cationic or zwitterionic substances with good dispersing, emulsifying and wetting properties depending on the nature of the compound according to general formula I to be formulated. Surfactants may also mean mixtures of individual surfactants.

[0120] The compositions of the invention may for example be formulated as wettable powders, water dispersible granules, dusts, granules, solutions, emulsifiable concentrates, emulsions, suspension concentrates and aerosols. Wettable powders usually contain 5 to 90% w/w of active ingredient and usually contain in addition to solid inert carrier, 3 to 10% w/w of dispersing and wetting agents and, where necessary, 0 to 10% w/w of stabilizer(s) and/or other additives such as penetrants or stickers. Dusts are usually formulated as a dust concentrate having a similar composition to that of a wettable powder but without a dispersant, and may be diluted in the field with further solid carrier to give a composition usually containing 0.5 to 10% w/w of active ingredient. Water dispersible granules and granules are usually prepared to have a size between 0.15 mm and 2.0 mm and may be manufactured by a variety of techniques. Generally, these types of granules will contain 0.5 to 90% w/w active ingredient and 0 to 20% w/w of additives such as stabilizer, surfactants, slow release modifiers and binding agents. The so-called “dry flowables” consist of relatively small granules having a relatively high concentration of active ingredient. Emulsifiable concentrates usually contain, in addition to a solvent or a mixture of solvents, 1 to 80% w/v active ingredient, 2 to 20% w/v emulsifiers and 0 to 20% w/v of other additives such as stabilizers, penetrants and corrosion inhibitors. Suspension concentrates are usually milled so as to obtain a stable, non-sedimenting flowable product and usually contain 5 to 75% w/v active ingredient, 0.5 to 15% w/v of dispersing agents, 0.1 to 10% w/v of suspending agents such as protective colloids and thixotropic agents, 0 to 10% w/v of other additives such as defoamers, corrosion inhibitors, stabilizers, penetrants and stickers, and water or an organic liquid in which the active ingredient is substantially insoluble; certain organic solids or inorganic salts may be present dissolved in the formulation to assist in preventing sedimentation and crystalization or as antifreeze agents for water.

[0121] Aqueous dispersions and emulsions, for example compositions obtained by diluting the formulated product according to the invention with water, also lie within the scope of the invention.

[0122] Of particular interest in enhancing the duration of the protective activity of the compounds of this invention is the use of a carrier which will provide slow release of the pesticidal compounds into the environment of a plant which is to be protected.

[0123] The biological activity of the active ingredient can also be increased by including an adjuvant in the formulation or the spray dilution. An adjuvant is defined here as a substance which can increase the biological activity of an active ingredient but is not itself significantly biologically active. The adjuvant can either be included in the formulation as a coformulant or carrier, or can be added to the spray tank together with the formulation containing the active ingredient.

[0124] As a commodity the compositions may preferably be in a concentrated form whereas the end user generally employs diluted compositions. The compositions may be diluted to a concentration down to 0.001% of active ingredient. The doses usually are in the range from 0.01 to 10 kg a.i./ha.

[0125] Examples of formulations which can be used according to the invention are:

1SC-I 1active ingredientBP-1100.0 gDispersing agentMotwet D4251) 25.0 gDispersing agentPluronic ® PE105002) 5.0 gAntifoaming agentRhodorsil ® 426R3) 1.5 gDispersing agentRhodopol ® 233) 2.0 gAntifreezing agentPropylene glycol 80.0 gBiocidal agentProxel ® GXL4) 1.0 gWaterto 1000 mlSC-I 2active ingredientBP-4100.0 gDispersing agentSoprophor ® FL3) 30.0 gAntifoaming agentRhodorsil ® 426R3) 1.5 gDispersing agentRhodopol ® 233) 2.0 gAntifreezing agentPropylene glycol 80.0 gBiocidal agentProxel ® GXL4) 1.0 gWaterto 1000 mlSC-A-Eactive ingredientfungicide selected from classes200.0 g(A) through (E)Dispersing agentSoprophor ® FL3) 25.0 gAntifoaming agentRhodorsil ® 426R3) 1.5 gDispersing agentRhodopol ® 233) 2.0 gAntifreezing agentPropylene glycol 80.0 gBiocidal agentProxel ® GXL4) 1.0 gWaterto 1000 mlSC-I + A-Eactive ingredientBP-4 60.0 gactive ingredientfungicide selected from classes120.0 g(A) through (E)Dispersing agentSoprophor ® FL3) 25.0 gAntifoaming agentRhodorsil ® 426R3) 1.5 gDispersing agentRhodopol ® 233) 2.0 gAntifreezing agentPropylene glycol 80.0 gBiocidal agentProxel ® GXL4) 1.0 gWaterto 1000 mlDC-I 1active ingredientBP-4100.0 gWetting agentPluronic ® PE64002) 50.0 gDispersing agentLutensol ® TO 122) 50.0 gSolventbenzyl alcoholto 1000 ml1)Product commercially available from Witco 2)Product commercially available from BASF AG, Germany 3)Product commercially available from Rhône-Poulenc 4)Product commercially available from Zeneca

[0126] (i) a containment which comprises at least one benzophenone of formula I, in particular one or more compounds selected from BP-1 through BP-4, conventional carriers and optionally adjuvants;

[0127] (ii) a containment which comprises at least one active ingredient selected from the classes (A) through (E).

[0128] In a preferred embodiment the said kit will consist of two bottles with dispensing means which allow the easy and correct addition of the active ingredients (a) and (b) to the tank mix.

[0129] The formulation SC-I+A-E comprising BP-4 and a fungicidal active ingredient selected from the classes (A) through (E) as defined above can be used directly for preparing the tank mix according to the present invention.

[0130] A composition according to the invention preferably contains from 0.5% to 95% by weight of active ingredients.

[0131] As commodity the compositions may preferably be in a concentrated form whereas the end-user generally employs diluted compositions. The compositions may be diluted down to a concentration of 0.0001% of active ingredients.

[0132] The compositions of this invention can be applied to the plants or their environment simultaneous with or in succession with other active substances. These other active substances can be either fertilizers, agents which donate trace elements or other preparations which influence plant growth. However, they can also be other fungicides, selective herbicides, insecticides, bactericides, nematicides, algicides, molluscidides, rodenticides, virucides, compounds inducing resistance into plants, biological control agents such as viruses, bacteria, nematodes, fungi and other microorganisms, repellents of birds and animals, and plant growth regulators, or mixtures of several of these preparations, if appropriate together with other carrier substances conventionally used in the art of formulation, surfactants or other additives which promote application.

[0133] Examples of insecticidal compounds are alpha-cypermethrin, benfuracarb, BPMC, buprofezine, carbosulfan, cartap, chlorfenvinphos, chlorpyrifos-methyl, cycloprothrin, cypermethrin, esfenvalerate, ethofenprox, fenpropathrin, flucythrinate, flufenoxuron, hydramethylnon, imidacloprid, isoxathion, MEP, MPP, nitenpyram, PAP, permethrin, propaphos, pymetrozine, silafluofen, tebufenozide, teflubenzuron, temephos, terbufos, tetrachlorvinphos and triazamate.

[0134] Examples of biological control agents are: Bacillus thuringiensis, Verticillium lecanii, Autographica californica NPV, Beauvaria bassiana, Ampelomyces quisqualis, Bacilis subtilis, Pseudomonas cholororaphis, Pseudomonas fluorescens, Steptomyces griseoviridis and Trichoderma harzianum.

[0135] Examples of chemical agents that induce systemic acquired resistance in plants such are: isonicotinic acid or derivatives thereof, 2,2-dichloro-3,3-dimethylcyclopropylcarboxylic acid.

[0136] The present invention is of wide applicability in the protection of crops, trees, residential and ornamental plants against fungal attack. Preferred crops are cereals, such as wheat and barley, rice as well as vines and apples. The duration of the protection is normally dependent on the individual compound selected, and also a variety of external factors, such as climate, whose impact is normally mitigated by the use of a suitable formulation.

[0137] The following examples further illustrate the present invention. It should be understood, however, that the invention is not limited solely to the particular examples given below.

EXAMPLES

[0138] General Methods

[0139] The trials are carried out under greenhouse (Examples 1 to 18) or field conditions (Example 19) in residual or curative applications. The fungicides are applied in single treatments, or in a combination comprising a benzophenone of formula I and a compound selected from the classes (A) through (E) as defined above. The compounds are applied in form of an aqueous spray mix obtained from concentrated formulation or the technical material.

[0140] I. Cereals and Dicots—Greenhouse

[0141] 1. Seed is planted in 6 cm diameter plastic pots and maintained in the greenhouse.

[0142] 2. When the primary leaf is fully expanded in the case of cereals or several leaves are present in the case of dicots, formulated test compounds are sprayed with a three nozzle overhead fungicide sprayer to near run-off. Alternatively, a single nozzle overhead track sprayer is used for application of the compounds to cereals at a rate of 200 l/ha. Plants are then allowed to air-dry.

[0143] 3. Inoculation precedes treatment in the case of curative evaluations and follows treatment in case of residual evaluations. For inoculation of powdery mildew disease, plants are set up on greenhouse benches with bottom watering mats and inoculated by dusting them with conidia from infected plants. Between inoculation and treatment for curative evaluations and between treatment and inoculation for residual evaluations, plants are maintained in the greenhouse with bottom watering. For inoculation of non-powdery mildew diseases, an aqueous spore suspension of the pathogen is applied to the plant and the plants are kept 1-2 days in a moist infection chamber before being returned to the greenhouse where they are maintained by bottom watering.

[0144] 4. Disease on the foliage as percent leaf area with disease symptoms/signs is evaluated about 7 days after inoculation. In the case of wheat, the tips and bases of the leaves are excluded from the evaluation.

% disease control = 100 - \frac{% disease in treated plants}{% disease in untreated plants} \times 100 %

[0145] Formulation, Reference Compounds and Controls

[0146] 1. Technical compounds are formulated in a solvent/surfactant system consisting of 5% acetone and 0.05% Tween 20 in deionized water. Compounds are dissolved in acetone prior to addition of the water; the Tween 20 can be added through either the acetone or the water. Dilutions are made using the solvent/surfactant system. Formulated compounds are prepared using deionized water.

[0147] 2. Two kinds of controls are included:

[0148] Plants treated with the solvent/surfactant solution and inoculated (Solvent Blank).

[0149] Untreated plants which are inoculated (Inoculated Control). For the field study formulated benzophenones BP-1 through BP-4 and formulated compounds from the classes (A) through (E) were used.

[0150] Evaluation of the Disease

[0151] Assessments of the diseases took place at the indicated day after the application of the compounds. Per cent infected leaf area infected was evaluated. The efficacy of the compounds/compounds mixtures to control the diseases was calculated by using the formula given above under item 4:

[0152] II. Apple Fruit Botrytis

[0153] 1. Apples (Malus X domestica Borkh.) variety “Golden Delicious” are disinfected by washing them briefly in 70% ethanol. After drying the apples are marked with four short equal-distant lines indicating the positions to be wounded.

[0154] 2. Corresponding with the marks, four holes are poked around the apple equator with a pipette tip. 10 μl of the treatment solution are pipetted into each hole.

[0155] 3. Three hours after application, 10 μl of a conidial suspension of Botrytis cinerea are pipetted into each hole. For incubation, the treated/inoculated apples are stored for five days.

[0156] 4. Disease occurs as rotten apple tissue surrounding the inoculated wounds.

[0157] The diameter of the rotten zone around each wound is measured.

[0158] Formulation, Reference Compounds and Controls: 1.

[0159] Technical compounds are formulated in a solvent system consisting of 5% acetone and 0.05% Tween 20 in deionized water.

[0160] Compounds are dissolved in acetone prior to dilution with water.

[0161] Formulated compounds are prepared using deionized water.

[0162] 2. Three kinds of controls are included:

[0163] Apples treated with the solvent solution and inoculated (Solvent Blank).

[0164] Untreated apples which are inoculated (Inoculated Control).

[0165] Untreated apples which are not inoculated (Uninoculated Control).

[0166] Evaluation of the Disease:

[0167] Assessments of the diseases took place at the indicated day after the application of the compounds. Per cent infected leaf area infected was evaluated. The efficacy of the compounds/compounds mixtures to control the diseases was calculated by using the formula:

% disease control = 100 - \frac{mean of diameters on treated apples}{mean of diameters on untreated apples} \times 100 %

[0168] Determination of Synergy

[0169] Synergy was calculated using the % disease control values of specific treatments for the two COLBY formula given hereinabove

[0170] III. Field Tests

[0171] The compounds are applied according to good agricultural practice in form of an aqueous spray mix obtained from concentrated formulation or the technical material at a rate of 400 l/ha. The disease control is evaluated according to the formula given for the greenhouse tests.

[0172] A Greenhouse Tests

Example 1

[0173] Fungicidal efficacy of the mixture of BP-1+AP-1 (4 day curative) against Erysiphe graminis on wheat

[0174] The tank mix was obtained from technical materials of BP-1 and AP-1. The observed and expected efficacies with different rates are given in Table I:

2TABLE Idose rate (ppm)BP-1AP-1Observed EfficacyExpected Efficacy125042—2501—01250—0250—125125564212525544225125211252541

Example 2

[0175] Fungicidal efficacy of the mixture of BP-1+AP-2 (4 day curative) against Erysiphe graminis on wheat

[0176] The tank mix was obtained from technical materials of BP-1 and AP-2. The observed and expected efficacies with different rates are given in Table II:

3TABLE IIdose rate (ppm)BP-1AP-2Observed EfficacyExpected Efficacy125042—125042—2501—01258—0250—125125674712525734225125209252591

Example 3

[0177] Fungicidal efficacy of the mixture of BP-1+triadimefon (4 day curative) against Erysiphe graminis on wheat

[0178] The tank mix was obtained from technical material of BP-1 and a wettable powder formulation containing 250 g/kg triadimefon. The observed and expected efficacies with different rates are given in Table III:

4TABLE IIIdose rate (ppm)BP-1triadimefonObserved EfficacyExpected Efficacy125042—2501—012530—02512—12512585591252556492512541312525613

Example 4

[0179] Fungicidal efficacy of the mixture of BP-5+triforine (3 day protective) against Erysiphe graminis on wheat

[0180] The tank mix was obtained from technical material of BP-5 and an EC formulation containing 190 g/l triforine. The observed and expected efficacies with different rates are given in Table IV:

5TABLE IVdose rate (ppm)BP-5triforineObserved EfficacyExpected Efficacy25031—5012—012512—2512559415252624

Example 5

[0181] Fungicidal efficacy of the mixture of BP-1+triadimefon (3 day protective) against Erysiphe graminis on wheat

[0182] The tank mix was obtained from technical material of BP-1 and a wettable powder formulation containing 250 g/kg triadimefon. The observed and expected efficacies with different rates are given in Table V:

6TABLE Vdose rate (ppm)BP-1triadimefonObserved EfficacyExpected Efficacy5078—104402524—52590831257857

Example 6

[0183] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Erysiphe cichoracearum on cucumbers

[0184] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table VI:

7TABLE VIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%6410016514611DithianonWG 700 g/kg256064016040CyprodinilTC 100 %2561564016040TriforineEC 190 g/l256966479164441FenpropidinEC 750 g/l25669642116640MancozebWP 800 g/kg2563364116040QuinoxyfenTC 100%2561006410016100490ChlorothalonilSC 500 g/l256164016040EthirimolSC 280 g/l25610064941683450DimethomorphTC 100%2561864016040BIONWG 500 g/kg256064016040AzoxystrobinTC 100%256100641001696478BP-4 +Tankmix64 + 256100100Dithianon16 + 6473514 + 163161 + 4291BP-4 +Tankmix64 + 25692100Cyprodinil16 + 6459514 + 165161 + 4321BP-4 +Tankmix64 + 256100100Triforine16 + 6499904 + 1665471 + 4313BP-4 +Tankmix64 + 256100100Fenpropidin16 + 6496614 + 1660121 + 4561BP-4 +Tankmix64 + 256100100Mancozeb16 + 6499524 + 165461 + 4381BP-4 +Tankmix64 + 256100100Quinoxyfen16 + 641001004 + 161001001 + 410091BP-4 +Tankmix64 + 256100100Chlorothalonil16 + 6499514 + 162261 + 4141BP-4 +Tankmix64 + 256100100Ethirimol16 + 64100974 + 1685841 + 45351BP-4 +Tankmix64 + 256100100Dimethomorph16 + 6499514 + 163761 + 4101BP-4 +Tankmix64 + 256100100BION16 + 6453514 + 161261 + 411BP-4 +Tankmix64 + 256100100Azoxystrobin16 + 641001004 + 1699961 + 49278

Example 7

[0185] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Puccinia recondita on wheat

[0186] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table VII:

8TABLE VIIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%2561364016040DithianonWG 700 g/kg256956484161644CyprodinilTC 100%256064016040TriforineEC 190 g/l256100649016740FenpropidinEC 750 g/l2569764816040MancozebWP 800 g/kg25691642816040QuinoxyfenTC 100%256064016040ChlorothalonilSC 500 g/l2563164016040EthirimolSC 280 g/l2560640160DimethomorphTC 100%2560640160BIONWG 500 g/kg256064016040BP-4 +Tankmix256 + 25610095Dithianon64 + 641008416 + 16100164 + 41004BP-4 +Tankmix256 + 25610013Cyprodinil64 + 64100016 + 1610004 + 41000BP-4 +Tankmix256 + 256100100Triforine64 + 641009016 + 1610074 + 41000BP-4 +Tankmix256 + 25610097Fenpropidin64 + 6496816 + 169304 + 4910BP-4 +Tankmix256 + 25610092Mancozeb64 + 64972816 + 169404 + 4920BP-4 +Tankmix256 + 2568913Quinoxyfen64 + 6496016 + 169504 + 4930BP-4 +Tankmix256 + 25610040Chlorothalonil64 + 6436016 + 164004 + 490BP-4 +Tankmix256 + 2569613Ethirimol64 + 6496016 + 16640BP-4 +Tankmix256 + 2565413Dimethomorph64 + 6428016 + 1660BP-4 +Tankmix256 + 2567513BION64 + 6478016 + 166404 + 4590

Example 8

[0187] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Leptosphaeria nodorum on wheat

[0188] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table VIII:

9TABLE VIIIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%25634641416040DithianonWG 700 g/kg25674643716140CyprodinilTC 100%256936488167540TriforineEC 190 g/l25685645116314410FenpropidinEC 750 g/l25621640MancozebWP 800 g/kg256696447162140QuinoxyfenTC 100%25618640161DimethomorphTC 100%25614641116641AzoxystrobinTC 100%256100641001697484BP-4 +Tankmix256 + 2569083Dithianon64 + 64654616 + 162714 + 440BP-4 +Tankmix256 + 2569796Cyprodinil64 + 64929016 + 1680754 + 4570BP-4 +Tankmix256 + 2569790Triforine64 + 64845816 + 1647314 + 4324BP-4 +Tankmix256 + 2564248Fenpropidin64 + 642114BP-4 +Tankmix256 + 2568779Mancozeb64 + 64655516 + 1632214 + 480BP-4 +Tankmix256 + 2566246Quinoxyfen64 + 64341416 + 1681BP-4 +Tankmix256 + 2568443CL336 37064 + 646524Dimethomorph16 + 163164 + 4141BP-4 +Tankmix256 + 256100100Azoxystrobin64 + 6410010016 + 1698974 + 49584

Example 9

[0189] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Puccinia recondita on wheat

[0190] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table IX:

10TABLE IXdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%25638641616446CaptanWP 500 g/kg256896455161144FluazinamSC 500 g/l25680642216640MetalaxylTC 100%25612640FenpiclonilTC 100%25658641816041FamoxadoneTC 100%64921680445BP-4 +Tankmix256 + 2569593Captan64 + 64656216 + 163015BP-4 +Tankmix256 + 2569788Fluazinam64 + 64533516 + 162010BP-4 +Tankmix256 + 2566146Metalaxyl64 + 641916BP-4 +Tankmix256 + 2568174Fenpiclonil64 + 64543116 + 161244 + 477BP-4 +Tankmix64 + 649393Famoxadone16 + 1683814 + 46048

Example 10

[0191] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Leptosphaeria nodorum on wheat

[0192] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table X:

11TABLE Xdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%256446418161040DodineWP 650g/kg25659642416640CaptanWP 500g/kg256906484FluazinamSC 500g/l256916481FamoxadoneTC 100%2569764801669466BP-4 +Tankmix256 + 2567577Dodine64 + 64573816 + 1629154 + 4100BP-4 +Tankmix256 + 2569694Captan64 + 649387BP-4 +Tankmix256 + 2569595Fluazinam64 + 649184BP-4 +Tankmix256 + 2569498Famoxadone64 + 64898416 + 1686724 + 46766

Example 11

[0193] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Erysiphe cichoracearum on cucumbers

[0194] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table XI:

12TABLE XIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%50961055220.40Sulfur inorganicTC 100%500107200.40PropiconazoleEC 250g/l509610762190.40EpoxiconazoleSC 125g/l507710682460.40TebuconazoleEC 250g/l509510792450.410MetconazoleSL 60g/l509910750.42MyclobutanilWP 60g/kg509610732520.436Kresoxim-WG 500g/kg50100methyl10882140.42AC 382042TC 100%50251014230.47BRIOSE 450g/l5096Epoxiconazole/(150g/l)/1048Fenpropimorph(300g/l)ACROBAT MZWP 690g/kg5057Dimethomorph/(90g/kg)/1030Mancozeb(600g/kg)200.40JUWELSC 250g/l50100Kresoxim-methyl/(125g/l)/1098Epoxiconazole.(125g/l)2710.437BP-4Tankmix50 + 509296Sulfur inorganic10 + 1070582 + 21020.4 + 0.490BP-4Tankmix50 + 50100100Propiconazole10 + 10100892 + 261210.4 + 0.4280BP-4Tankmix50 + 5010099Epoxiconazole10 + 1098862 + 271470.4 + 0.4410BP-4Tankmix50 + 50100100Tebuconazole10 + 1098912 + 248450.4 + 0.42810BP-4Tankmix50 + 50100100Metconazole10 + 1097890.4 + 0.452BP-4Tankmix50 + 50100100Myclobutanil10 + 1099882 + 275520.4 + 0.45536BP-4Tankmix50 + 50100100Kresoxim-10 + 1010095methyl2 + 237150.4 + 0.422BP-4Tankmix50 + 5010097AC 38204210 + 1087622 + 22850.4 + 0.4257BP-4Tankmix50 + 50100100BRIO10 + 108577BP-4Tankmix50 + 5010098ACROBAT MZ10 + 1089692 + 24520.4 + 0.470BP-4Tankmix50 + 50100100JUWEL10 + 1098992 + 284720.4 + 0.45037

Example 12

[0195] Fungicidal efficacy of the mixture of BP-4+Myclobutanil (4 day residual) against Puccinia recondita on wheat

[0196] The tank mixes were obtained from technical material of BP-4 and Myclobutanil. The type of formulation, the observed and expected efficacies with different rates are given in Table XII:

13TABLE XIIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%50311010270.42MyclobutanilWP 60g/kg509910722520.413BP-4Tankmix50 + 509999Myclobutanil10 + 1086752 + 265550.4 + 0.44814

Example 13

[0197] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Pyrenophora teres on barley

[0198] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table XIII:

14TABLE XIIIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%50581034200.40Sulfur inorganicTC 100%10020CopperWP 450g/kg5014oxychloride1014200.40PropiconazoleEC 250g/l50741038200.40MetconazoleSL 60g/l10470.40MyclobutanilWP 60g/kg508210402210.40Kresoxim-WG 500g/kg221methyl0.40ACROBAT MZWP 690g/kg5047Dimethomorph/1023Mancozeb2120.40JUWELSC 250g/l5089Kresoxim-1062methyl/245Epoxiconazole0.45BP-4Tankmix10 + 104934Sulfur inorganic2 + 200BP-4Tankmix50 + 507864Copper10 + 105443oxychloride2 + 23800.4 + 0.400BP-4Tankmix50 + 508989Propiconazole10 + 1078592 + 23200.4 + 0.400BP-4Tankmix50 + 508986Tebuconazole2 + 21450.4 + 0.400BP-4Tankmix10 + 106965Metconazole2 + 225320.4 + 0.4180BP-4Tankmix50 + 509193Myclobutanil10 + 1067612 + 240210.4 + 0.470BP-4Tankmix2 + 26721Kresoxim-methyl0.4 + 0.4360BP-4Tankmix50 + 508578ACROBAT MZ10 + 1060492 + 229120.4 + 0.400BP-4Tankmix50 + 5010095JUWEL10 + 1078752 + 249450.4 + 0.4405

Example 14

[0199] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Erysiphe cichoracearum on cucumbers

[0200] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table XIV:

15TABLE XIVdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%50971013200.40CyproconazoleSL 100g/l10680.419DinocapWP 190g/kg100200.40FenarimolSC 125g/l506710422340.45FenpropimorphEC 750g/l107200.40FlusilazoleWP 200g/kg50381019200.40PenconazoleEC 100g/l506710372350.46ProchlorazEC 400g/l5018101200.40PyrifenoxWP 500g/kg5020101200.40TriadimefonWP 250g/kg50471023260.40TriadimenolEC 250g/l506810452210.41SpiroxamineEC 500g/l102200.40BP-4Tankmix10 + 108472Cyproconazole0.4 + 0.42319BP-4Tankmix50 + 509698Dinocap10 + 1030132 + 2200.4 + 0.420BP-4Tankmix50 + 5010099Fenarimol10 + 1092492 + 249340.4 + 0.4195BP-4Tankmix10 + 104319Fenpropimorph2 + 2600.4 + 0.420BP-4Tankmix50 + 5010098Flusilazole10 + 1057292 + 21400.4 + 0.410BP-4Tankmix50 + 5010099Penconazole10 + 1096452 + 266350.4 + 0.4236BP-4Tankmix50 + 5010098Prochloraz10 + 1071132 + 21100.4 + 0.470BP-4Tankmix50 + 5010098Pyrifenox10 + 1056132 + 2700.4 + 0.440BP-4Tankmix50 + 509999Triadimefon10 + 1039322 + 21560.4 + 0.420BP-4Tankmix50 + 5010099Triadimenol10 + 1078522 + 230210.4 + 0.491BP-4Tankmix10 + 103715Spiroxamine2 + 21000.4 + 0.420

Example 15

[0201] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Puccinia recondita on wheat

[0202] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table XV:

16TABLE XVdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%5012106200.40CyproconazoleSL 100g/l2990.488DinocapWP 190g/kg505410232130.44FenarimolSC 125g/l50901023290.40FenpropimorphEC 750g/l50602150.42FlusilazoleWP 200g/kg501002280.45PenconazoleEC 100g/l50261010230.40ProchlorazEC 400g/l5014101200.40PyrifenoxWP 500g/kg506101200.40TriadimenolEC 250g/l509810692210.41SpiroxamineEC 500g/l501710420BP-4Tankmix2 + 210099Cyproconazole0.4 + 0.49288BP-4Tankmix50 + 506160Dinocap10 + 1038282 + 226130.4 + 0.4104BP-4Tankmix50 + 509991Fenarimol10 + 1052282 + 21590.4 + 0.4120BP-4Tankmix50 + 508465Fenpropimorph2 + 219150.4 + 0.4132BP-4Tankmix50 + 50100100Flusilazole2 + 255280.4 + 0.4145BP-4Tankmix50 + 507835Penconazole10 + 1019162 + 2730.4 + 0.440BP-4Tankmix50 + 503425Prochloraz10 + 101272 + 2400.4 + 0.400BP-4Tankmix50 + 503118Pyrifenox10 + 101572 + 2500.4 + 0.440BP-4Tankmix50 + 509898Triadimenol10 + 1089712 + 239210.4 + 0.4101BP-4Tankmix50 + 504027Spiroxamine10 + 1011102 + 230

Example 16

[0203] Fungicidal efficacy of the mixture of BP-4+other fungicides (4 day residual) against Pyrenophora teres on barley

[0204] The tank mixes were obtained from technical material of BP-4 and different formulations of different active ingredients. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table XVI:

17TABLE XVIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%5011100200.40CyproconazoleSL 100g/l10124DinocapWP 190g/kg5022105200.40FenarimolSC 125g/l10420FenpropimorphEC 750g/l103200.40FlusilazoleWP 200g/kg5048102628ProchlorazEC 400g/l10482190.48PyrifenoxWP 500g/kg5015108101200.40SpiroxamineEC 500g/l5016105230.40BP-4Tankmix10 + 1091Cyproconazole2 + 2104BP-4Tankmix50 + 502931Dinocap10 + 101552 + 2500.4 + 0.490BP-4Tankmix10 + 1064Fenarimol2 + 210BP-4Tankmix10 + 1043Fenpropimorph2 + 2500.4 + 0.450BP-4Tankmix50 + 507054Flusilazole10 + 1049262 + 2268BP-4Tankmix10 + 104948Prochloraz2 + 230190.4 + 0.4198BP-4Tankmix50 + 502625Pyrifenox10 + 10108BP-4Tankmix50 + 502920Triadimefon10 + 10105BP-4Tankmix50 + 504621Triadimenol10 + 101912 + 2300.4 + 0.410BP-4Tankmix50 + 504326Spiroxamine10 + 102452 + 2630.4 + 0.430

Example 17

[0205] Fungicidal efficacy of the mixture of different benzophenones+metconazole (2 day curative) against Blumeria graminis f. sp. tritici on wheat

[0206] The tank mixes were obtained from technical material of the benzophenones BP-2 and BP-4 and metconazole. The benzophenones, the type of formulations, the observed and expected efficacies with different rates are given in Table XVII:

18TABLE XVIIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-2EC 100g/l546718256182130.674BP-4TC 100%549218786422270.679MetconazoleEC 100g/L274091437120.330BP-2Tankmix27 + 549080Metconazole 9 + 1867353 + 646231 + 222120.33 + 0.6794BP-4Tankmix27 + 549895Metconazole 9 + 1893813 + 64945

Example 18

[0207] Fungicidal efficacy of the mixture of BP-4+AP-4 (1 day residual) against Uncinula necator on vines

[0208] The tank mixes were obtained from technical material of BP-4 and AP-4. The active ingredients, the type of formulations, the observed and expected efficacies with different rates are given in Table XVIII:

19TABLE XVIIIdose rateObservedExpectedCompoundFormulation(ppm)EfficacyEfficacyBP-4TC 100%842443291280.5210.250AP-4TC 100%1760.5760.25500.12320.0670.0313BP-4Tank mix8 + 18886AP-4 4 + 0.59187 2 + 0.258579 1 + 0.128983 0.5 + 0.0688810.25 + 0.037976

[0209] B Field Tests

Example 19

[0210] Fungicidal efficacy of the mixture of BP-1+metconazole in the field against the sugar beet disease Cercospora beticola

[0211] The tank mix was obtained from a SC formulation containing 100 g of BP-1 per liter and a SL formulation containing 60 g of metconazole per liter. The observed and expected efficacies are given in Table XIX

20TABLE XIXdose rate g/haBP-1metconazoleObserved EfficacyExpected Efficacy250042.5— 09058—2509085.475.9

	Number	Date	Country
Parent	09240412	Jan 1999	US
Child	10046197	Jan 2002	US

Fungicidal mixtures

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