Claims
- 1. A compound of formula I ##STR27## in which R.sup.1 is lower alkyl; R.sup.2 is lower alkyl; R.sup.3 is hydrogen or lower alkyl; and R.sup.4 is chloro, bromo, p-toluenesulfonyl or a radical of formula Y--X wherein Y is O and X is lower alkyl, phenyl, or a radical of formula Z--R.sup.9 wherein Z is lower alkylene or hydroxy(lower)alkylene and R.sup.9 is phenyl, or a therapeutically acceptable salt thereof.
- 2. A compound of formula I ##STR28## in which R.sup.1 is lower alkyl; R.sup.2 is lower alkyl; R.sup.3 is hydrogen; and R.sup.4 is chloro, bromo, p-toluenesulfonyl or a radical of formula Y--X wherein Y is O and X is phenyl or a radical of formula Z--R.sup.9 wherein Z is lower alkylene or hydroxy(lower)alkylene and R.sup.9 is phenyl, or a therapeutically acceptable salt thereof.
- 3. 1,3-Dihydro-3,3-dimethylfuro[3,4-b]quinolin-9-ol p-toluenesulfonate, as claimed in claim 1.
- 4. 9-Chloro-1,3-dihydro-3,3-dimethylfuro[3,4-b]quinoline, as claimed in claim 1.
- 5. 3,3-Dimethyl-9-phenoxy-1,3-dihydrofuro[3,4-b]quinoline, as claimed in claim 1.
- 6. A compound of formula VI ##STR29## in which R.sup.1 is lower alkyl; R.sup.2 is lower alkyl or a radical of formula ##STR30## wherein m is an integer from 1 to 5 and R.sup.5 and R.sup.6 each is lower alkyl; and R.sup.3 is hydrogen, lower alkyl or a radical of formula (CH.sub.2).sub.n NR.sup.7 R.sup.8 wherein n is an integer from 1 to 6 and R.sup.7 and R.sup.8 each is lower alkyl.
- 7. 3,4-Dihydro-3,3-dimethylfuro[3,4-b]quinolin-9(1H)-one, as claimed in claim 6.
- 8. 1,3,4,9-Tetrahydro-N,N,3-trimethyl-9-oxo-furo[3,4-b]quinolin-3-acetamide, as claimed in claim 6.
- 9. 3,4-Dihydro-1-[(dimethylamino)methyl]-3,3-dimethylfuro[3,4-b]quinolin-9(1H)-one, as claimed in claim 6.
- 10. A method for treating microbial infections in a mammal which comprises administering to said mammal an effective antimicrobial amount of a compound of claim 1, or a therapeutically acceptable salt thereof.
- 11. An antimicrobial composition comprising an effective amount of a compound of claim 1, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
Parent Case Info
This is a division of application Ser. No. 739,779, filed Nov. 8, 1976, now U.S. Pat. No. 4,108,998 issued Mar. 7, 1978.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
2650229 |
Timmler et al. |
Aug 1953 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
7243958 |
Sep 1968 |
JPX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
739779 |
Nov 1976 |
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