Claims
- 1. A compound of the formula: ##STR49## or a pharmaceutically acceptable salt thereof wherein X is --CH.dbd.CH--;
- wherein Z is --NR.sup.4 R.sup.5 ;
- wherein R.sup.2 is H, --CH.sub.3 or --C.sub.2 H.sub.5 ;
- wherein R.sup.3 is OH, H or .dbd.O; and
- wherein R.sup.4 and R.sup.5 may independently be hydrogen, or lower alkyl having 1-6 carbon atoms.
- 2. A compound according to claim 1 of the formula ##STR50## or a pharmaceutically acceptable salt thereof, wherein Y is ##STR51## wherein Z is --NR.sup.4 R.sup.5 ; wherein R.sup.2 is --CH.sub.3 or --C.sub.2 H.sub.5 ;
- wherein R.sup.3 is OH, H or .dbd.O; and
- wherein R.sup.4 and R.sup.5 may independently be hydrogen, or lower alkyl having 1-6 carbon atoms.
- 3. A pharmaceutical composition comprising a therapeutically or prophylactically effective amount of a compound according to claim 1 in a pharmaceutically acceptable carrier.
- 4. A pharmaceutical composition according to claim 3 wherein said composition is in oral dosage form.
- 5. A method of treating inflammatory conditions in mammals comprising administering to a patient in need of such treatment, a therapeutically effective amount of pharmaceutical composition according to claim 3.
- 6. A method of preventing an inflammatory attack in mammals comprising administering to a patient susceptible to such attack a prophylactically effective amount of a compound according to claim 1 in a pharmaceutically acceptable carrier.
Parent Case Info
This application is a division of U.S. Ser. No. 07/158,454 filed Feb. 18, 1988 now U.S. Pat. No. 4,855,324 which is a Continuation-in-Part of U.S. Pat. Ser. No. 07/130,355 filed Dec. 8, 1987, now abandoned.
US Referenced Citations (3)
Non-Patent Literature Citations (7)
Entry |
Biochem and Biophys. Res. Comm., 138, 540-546 (1986). |
Lewis et al., J. Clin. Inves., 73, 889-897 (1984). |
Bray, Brit. Medical Bull., 39, 249-254 (1983). |
Furber et al., J. Chem. Soc., Perkin Trans I, 7, 1573 (1987). |
Chem. Abstracts No. 84-271464/44. |
Derwent No. 85-249007/40. |
Derwent No. 85-249005/40. |
Divisions (1)
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Number |
Date |
Country |
Parent |
158454 |
Feb 1988 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
130355 |
Dec 1987 |
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