Claims
- 1. compound of the formula: n is an integer from one to four; R3 is hydrogen or C1-C6 alkyl; R4 is hydrogen or C1-C6 alkyl; and Rp represents a structure of the formula where Q representi an alkylene group of 2 to 6 carbon atoms optionally substituted with one or more alkyl groups having from 1 to 4 carbon atoms; W is phenyl or naphthyl, each of which is optionally substituted with up to three groups independently selected from halogen, C1-C6 alkyl, C1-C4 alkoxy, thioalkoxy, hydroxy, amino, monoalkylamino, dialkylamino, cyano, nitro, trifluoromethyl and trifluoromethoxy.
- 2. A compound of the formula: whereinn is an integer from one to three; R3 is hydrogen or C1-C6 alkyl; R4 is hydrogen or C1-C6 alkyl; and Rp represents a structure of the formula where Q represents an alkylene group of 2 to 6 carbon atoms optionally substituted with one or more alkyl groups having from 1 to 4 carbon atoms; and W is phenyl or naphthyl, each of which is optionally substituted with up to three groups independently selected from halogen, C1-C6 alkyl, C1-C6 alkoxy, thioalkoxy, hydroxy, amino, monoalkylamino, dialkylamino, cyano, nitro, trifluoromethyl and trifluoromethoxy.
- 3. A compound according to claim 2, which is: where W is naphthyl or W is phenyl optionally substituted with up to 3 groups independently selected from halogen, C1-C6 alkyl, and C1-C6 alkoxy.
- 4. A compound of the formula: whereinR3 is hydrogen or C1-C6 alkyl; R4 is hydrogen or C1-C6 alkyl; and Rp represents a structure of the formula where Q represents an alkylene group of 2 to 6 carbon atoms optionally substituted with one or more alkyl groups having from 1 to 4 carbon atoms; and W is phenyl or naphthyl, each of which is optionally subsituted with up to three groups independently selected from halogen, C1-C6 alkyl, C1-C4 alkoxy, thioalkqxy, hydroxy, amino, monoalkylamino, dialkylamino, cyano, nitro, trifluoromethyl and trifluoromethoxy.
- 5. A compound according to claim 4, which is: where W is naphthyl or W is phenyl optionally substituted with up to 3 groups independently selected from halogen, C1-C6 alkyl, and C1-C6 alkoxy.
- 6. A compound of the formula: whereinR3 is hydrogen or C1-C6 alkyl; R4 is hydrogen or C1-C6 alkyl; and Rp represents a structure of the formula where Q represents an alkylene group of 2 to 6 carbon atoms optionally substituted with one or more alkyl groups having from 1 to 4 carbon atoms; and W is phenyl or naphthyl; each of which is optionally subsituted with up to three groups independently selected from halogen, C1-C6 alkyl, C1-C4 alkoxy, thioalkqxy, hydroxy, amino, monoalkylamino, dialkylamino, cyano, nitro, trifluoromethyl and trifluoromethoxy.
- 7. A compound according to claim 6, which is: where W is naphthyl or W is phenyl optionally substituted with up to 3 groups independently selected from halogen, C1-C6 alkyl, and C1-C6 alkoxy.
Parent Case Info
This application is a national phase application filed under 35 U.S.C. §371 of International Application PCT/US97/13973, filed Aug. 12, 1997, which is a continuation-in-part of U.S. application Ser. No. 08/695,712 filed on Aug. 12, 1996, now U.S. Pat. No. 5,892,041.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US97/13973 |
|
WO |
00 |
10/28/1999 |
10/28/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO98/06717 |
2/19/1998 |
WO |
A |
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3932456 |
Albrecht et al. |
Jan 1976 |
|
5395835 |
Glase et al. |
Mar 1995 |
|
5892041 |
Yuan et al. |
Apr 1999 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
9414773 |
Jul 1994 |
WO |
Non-Patent Literature Citations (1)
Entry |
Murray, P. John, et al., “A Novel Series of Arylpiperazines With High Affinity and Selectivity For The Dopamine D3 Receptor,” Bioorg. & Med. Chem. Let., vol. 5, No. 3, pp. 219-222 (1995). |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
08/695712 |
Aug 1996 |
US |
Child |
09/242369 |
|
US |