Claims
- 1. A compound selected from the group consisting of ##SPC10##
- and the pharmaceutically acceptable cation salts thereof wherein R is selected from the group consisting of methyl, ethyl, acetyl and COR.sup.o wherein
- R.sup.o is selected from the group consisting of hydroxy, alkoxy having 1 to 4 carbon atoms, hydroxyalkoxy having 2 to 4 carbon atoms, amino and hydroxyamino;
- Y is selected from the group consisting of (a) hydrogen, and (b) alkyl having 1 to 4 carbon atoms, carbalkoxyalkyl having 2 to 5 carbon atoms in the carbalkoxy moiety and 1 to 4 carbon atoms in the alkyl moiety, carboxyalkyl having 1 to 4 carbon atoms in the alkyl moiety, --(CH.sub.2).sub.m -O-CO-C.sub.6 H.sub.5 and --(CH.sub.2).sub.m -O-CO-alkyl having 1 to 4 carbon atoms in the alkyl moiety; with the provisos that when R is methyl or ethyl, Y is selected from group (b); and when R is COR.sup.o wherein R.sup.o is amino or hydroxyamino, Y is hydrogen; m is an integer from 2 up to and including 4;
- R.sub.1 is selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms and phenyl;
- each of R.sub.2, R.sub.3, R.sub.4 and R.sub.5 is selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halo, benzyloxy, hydroxyl, thiol, alkanoyloxy having 1 to 4 carbon atoms, benzylthio, benzoyloxy, benzylsulfinyl, methylthio and methylsulfinyl; and
- R.sub.2 and R.sub.3, and R.sub.3 and R.sub.4 when taken together are selected from the group consisting of methylenedioxy and ethylenedioxy.
- 2. A compound according to claim 1 wherein each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, Y and R.sub.5 is hydrogen; and R is COR.sup.o wherein R.sup.o is said alkoxy.
- 3. A compound according to claim 1 wherein each of R.sub.1, R.sub.2, R.sub.5, and Y is hydrogen; R is COR.sup.o ; and each of R.sup.o, R.sub.3 and R.sub.4 is said alkoxy.
- 4. A compound according to claim 1 wherein each of R.sub.1, R.sub.2, R.sub.5 and Y is hydrogen; R is COR.sup.o wherein R.sup.o is hydroxy; and each of R.sub.3 and R.sub.4 is said alkoxy.
- 5. A compound according to claim 1 wherein each of R.sub.1, R.sub.2, R.sub.5, and Y is hydrogen; R is COR.sup.o wherein R.sup.o is said alkoxy; one of R.sub.3 and R.sub.4 is hydroxy and the other is said alkoxy.
- 6. A compound according to claim 3 wherein R.sup.o is ethoxy; and each of R.sub.3 and R.sub.4 is methoxy.
- 7. A compound according to claim 4 wherein each of R.sub.3 and R.sub.4 is methoxy.
- 8. A compound according to claim 5 wherein R.sup.o is n-butoxy; R.sub.3 is hydroxy; and R.sub.4 is methoxy.
- 9. A compound according to claim 5 wherein R.sup.o is ethoxy; R.sub.3 is methoxy; and R.sub.4 is hydroxy.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of our copending application, Ser. No. 444,138 filed Feb. 20, 1974, and now abandoned which in turn is a continuation-in-part of application Ser. No. 351,025, filed Apr. 13, 1973, and now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3790573 |
Blackburn et al. |
Feb 1974 |
|
3833588 |
Hardtmann |
Sep 1974 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
774,095 |
May 1957 |
UK |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
444138 |
Feb 1974 |
|
Parent |
351025 |
Apr 1973 |
|