Claims
- 1. A compound of the formula ##STR15## wherein A and B are each ethylene or (alkyl of 1 to 3 carbon atoms)-ethylene;
- R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, alkenyl of 3 to 6 carbon atoms, phenyl-(alkyl of 1 to 3 carbon atoms), halophenyl-(alkyl of 1 to 3 carbon atoms), alkanoyl of 1 to 3 carbon atoms, phenyl-(alkanoyl of 1 to 3 carbon atoms), halophenyl-(alkanoyl of 1 to 3 carbon atoms), alkoxycarbonyl of 2 to 4 carbon atoms, aralkoxycarbonyl of 8 to 10 carbon atoms or phenyl;
- one of R.sub.2 and R.sub.3 is amino and the other is hydrogen, chlorine, bromine, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, alkoxycarbonyl of 2 to 4 carbon atoms, phenyl or halophenyl;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 2. A compound of claim 1, where
- A and B are each ethylene or methyl-ethylene;
- R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms, allyl, cycloalkyl of 3 to 6 carbon atoms, phenyl-(alkyl of 1 to 3 carbon atoms), chlorophenyl-(alkyl of 1 to 3 carbon atoms), formyl, phenyl-formyl, chlorophenyl-formyl, acetyl, phenyl-acetyl, chlorophenyl-acetyl, ethoxy-carbonyl or phenyl;
- R.sub.2 is hydrogen, chlorine, bromine, methyl, ethyl, methoxy, phenyl or ethoxycarbonyl; and
- R.sub.3 is amino;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 3. A compound of claim 1, where
- A and B are ethylene;
- R.sub.1 is methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl or allyl;
- R.sub.2 is methyl, hydrogen, chlorine or bromine; and
- R.sub.3 is amino;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 4. A compound of claim 1, where
- A and B are ethylene;
- R.sub.1 is methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl or allyl;
- R.sub.2 is hydrogen; and
- R.sub.3 is amino;
- or a non-toxic, pharmacologically acceptable acid addition salts thereof.
- 5. A compound of claim 1, which is 2-amino-7-ethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 6. A compound of claim 1, which is 2-amino-7-methyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 7. A bradycardiac pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective bradycardiac amount of a compound of claim 1.
- 8. The method of slowing the heart rate of a warm-blooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective bradycardiac amount of a composition of claim 7.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3032994 |
Sep 1980 |
DEX |
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Parent Case Info
This is a division of copending application Ser. No. 297,024, filed Aug. 27, 1981, now U.S. Pat. No. 4,409,220.
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Divisions (1)
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Number |
Date |
Country |
Parent |
297024 |
Aug 1981 |
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