Claims
- 1. A method for treating arthritis which comprises administering to a subject in need of such treatment an effective amount of a fusidic acid derivative selected from compounds of the formula I: ##STR8## in which R.sub.1 stands for straight or branched alkyl or alkenyl with from 2 to 6 carbon atoms, for phenyl-lower alkyl or for furyl-lower alkyl; or pharmaceutically acceptable, non-toxic salts and easily hydrolysable esters thereof, and pharmaceutically acceptable, non-toxic salts of such esters.
- 2. A method according to claim 1 in which R.sub.1 in formula I stands for branched alkyl with from 3 to 6 carbon atoms, or for benzyl, phenethyl or furfuryl, or pharmaceutically acceptable, non-toxic salts and esters thereof, and pharmaceutically acceptable, non-toxic salts of such esters.
- 3. The method of claim 1 wherein the compound is 3.alpha.,11.alpha.-dihydroxy-16.beta.-isopropylthiofusida-13(17),24-dien-21-oic acid, or pharmaceutically acceptable, non-toxic salts or esters thereof or a pharmaceutically acceptable, non-toxic salt of such esters.
- 4. The method of claim 1 wherein the compound is 3.alpha.,11.alpha.-dihydroxy-16.beta.-benzylthiofusida-13(17),24-dien-21-oic acid, or pharmaceutically acceptable, non-toxic salts or esters thereof or a pharmaceutically acceptable, non-toxic salt of such ester.
- 5. A method according to claim 1 in which the therapeutically active compound is administered by the oral route, in amounts from 250 to 5000 mg per day, preferably from 500 to 3000 mg per day.
Priority Claims (2)
Number |
Date |
Country |
Kind |
49714/75 |
Dec 1975 |
GBX |
|
16015/76 |
Apr 1976 |
GBX |
|
Parent Case Info
This is a continuation-in-part of Ser. No. 906,664, filed May 16, 1978, which is a continuation of Ser. No. 744,978, filed Nov. 24, 1976, now U.S. Pat. No. 4,100,276. The subject matter of Ser. No. 906,664 and U.S. Pat. No. 4,100,276 is incorporated herein by reference.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4004004 |
Von Daehne |
Jan 1977 |
|
4100276 |
Von Daehne et al. |
Jul 1978 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
744978 |
Nov 1976 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
906664 |
May 1978 |
|