Claims
- 1. A method of identifying an agent that can enhance the immune response to a specific pathogen or against a specific vaccine comprising:(a) contacting an agent with a cell; wherein the cell encodes Bonzo/STRL33; and (b) determining the amount of Bonzo/STRL33 expressed by a cell in the presence of the agent; wherein the agent is identified as an agent that can enhance the immune response to a specific pathogen or against a specific vaccine when the amount of expression of Bonzo/STRL33 increases in the presence of the agent relative to in its absence.
- 2. The method of claim 1 wherein said determining is performed with an antibody raised against Bonzo/STRL33.
- 3. The method of claim 1 wherein said determining is performed by PCR.
- 4. An agent obtained by the method of claim 1.
- 5. A method of enhancing the immune response for a specific pathogen or to enhance the effect of a specific vaccine comprising administering the agent of claim 4 to an animal subject.
- 6. A method of identifying an agent that can enhance the immune response to a specific pathogen or against a specific vaccine comprising:(a) contacting an agent with a cell; wherein the cell normally encodes Bonzo/STRL33 but the coding sequence for Bonzo/STRL33 has been replaced by a coding sequence for a reporter gene; and (b) determining the amount of reporter gene expressed by a cell in the presence of the agent; wherein the agent is identified as an agent that can enhance the immune response to a specific pathogen or against a specific vaccine when the amount of expression of the reporter gene increases in the presence of the agent relative to in its absence.
- 7. The method of claim 6 wherein the coding sequence for the reporter gene encodes green fluorescent protein.
- 8. The method of claim 6 wherein the coding sequence for the reporter gene encodes luciferase.
- 9. An agent obtained by the method of claim 6.
- 10. A method of enhancing the immune response for a specific pathogen or to enhance the effect of a specific vaccine comprising administering the agent of claim 9 to an animal subject.
- 11. A method of identifying an agent that can inhibit the recruitment of memory cells comprising:(a) contacting an agent with a cell; wherein the cell encodes Bonzo/STRL33; and (b) determining the amount of Bonzo/STRL33 expressed by a cell in the presence of the agent; wherein the agent is identified as an agent that can inhibit the recruitment of memory cells when the amount of expression of Bonzo/STRL33 decreases in the presence of the agent relative to in its absence.
- 12. The method of claim 11 wherein said determining is performed with an antibody raised against Bonzo/STRL33.
- 13. The method of claim 11 wherein said determining is performed by PCR.
- 14. An agent obtained by the method of claim 11.
- 15. A method of treating inflammation comprising administering to an animal subject in need of such treatment an agent that causes a decrease in Bonzo/STRL 33 expression and/or function.
CROSS REFERENCE TO RELATED APPLICATIONS
The present Application is a continuation-in-part of copending Ser. No. 09/116,498, filed Jul. 16, 1998, now U.S. Pat. No. 6,251,582, which is a non-provisional application claiming priority to Provisional Patent Application Ser. No. 60/052,827 filed Jul. 17, 1997, the disclosures of which are hereby incorporated by reference in their entireties. Applicants claim the benefits of these applications under 35 U.S.C. §§119 (e) and 120.
GOVERNMENT SUPPORT
The research leading to the present inventions was funded in part by Grant No. RO1 AI 33303 from the National Institutes of Health. The government may have certain rights in the invention.
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6251582 |
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Jun 2001 |
B1 |
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Provisional Applications (1)
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Number |
Date |
Country |
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60/052827 |
Jul 1997 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09/116498 |
Jul 1998 |
US |
Child |
09/852156 |
|
US |