Claims
- 1. A method for treating a disease or disorder resulting from reduced neurosteroidal activation in a patient in need thereof, comprising administering to the patient a non-steroid compound which increases GABA activity in the brain.
- 2. The method of claim 1, wherein the non-steroid compound is a non-allosteric GABA agonist.
- 3. The method of claim 1, wherein the non-steroid compound has an affinity for the GABA complexes containing the α4 subunit
- 4. The method of claim 2, wherein the non-steroid compound has an affinity for the GABA complexes containing the α4 subunit
- 5. The method of claim 1, wherein the non-steroid compound is a GABA uptake inhibitor.
- 6. The method of claim 1, wherein the non-steroid compound is an enhancer of the GABAergic activity.
- 7. The method of any of claims 1 to 6, wherein the non-steroid compound is selected from the group consisting of THIP (Gaboxadol), cyclopropylGABA, isoguvacine, muscimol, imidazole-4-acetic acid, gabapentin and tiagabine.
- 8. The method of claim 1, wherein the disease or disorder results from fluctuations in the neurosteroid level.
- 9. The method of claim 1, wherein the disease or disorder results from decline in the neurosteroid level.
- 10. The method of claim 8 or 9, wherein the disease or disorder results from recurrent periodic decline in the neurosteroid level.
- 11. The method of claim 10, wherein the disease or disorder results from extraordinary decline in the neurosteroid level.
- 12. The method of claim 11, wherein the disease or disorder results from age-related decline in the neurosteroid level.
- 13. The method of claim 11, wherein the neurosteroid is progesterone.
- 14. The method of claim 11, wherein the neurosteroid is a metabolite of progesterone.
- 15. The method of claim 11, wherein the disease or disorder is selected from the group consisting of premenstrual disorder, postnatal depression or postmenopausal related dysphoric disorder.
- 16. The method of claim 1, wherein the disease or disorder is selected from the group consisting of premenstrual disorder, postnatal depression or postmenopausal related dysphoric disorder.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PA 2000 01743 |
Nov 2000 |
DK |
|
Parent Case Info
[0001] This application is a continuation of International Application No. PCT/DK01/00773, filed Nov. 20, 2001. The prior application is hereby incorporated by reference herein, in its entirety.
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/DK01/00773 |
Nov 2001 |
US |
Child |
10430704 |
May 2003 |
US |