Claims
- 1. A pharmaceutical composition for oral administration which is a microemulsion preconcentrate comprising 40-O-(2-hydroxy)ethyl rapamycin as active ingredient in a carrier medium which comprises
- i) a hydrophilic component, which, with co-components, if present, comprises 10 to 50% by weight of the carrier medium and which is Transcutol, Glycofurol, 1,2-propylene glycol, or mixtures thereof;
- ii) a lipophilic component, which comprises 10 to 85% by weight of the carrier medium and which is selected from the group consisting of 1) fatty acid triglycerides, 2) mixed mono-, di-,and tri-glycerides, and 3) transesterified ethoxylated vegetable oils; and
- iii) a surfactant, which comprises 5 to 80% by weight of the carrier medium and which is selected from the group consisting of polyethyleneglycol, natural or hydrogenated castor oils, polyethylene-sorbitan fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene-polyoxypropylene co-polymers, and block co-polymers
- the relative proportion of the active ingredient and components i), ii) and iii) being such that on dilution with water, a microemulsion having an average particle size of <1,500 .ANG. is spontaneously formed.
- 2. A composition of claim 1 wherein the surfactant is a polyoxyethylene sorbitan monolaurate, a polyoxyethylene sorbitan monopalmitate, a polyoxyethylene stearate, or a polyoxyethylene oleate.
- 3. A composition of claim 1 which further comprises one or more lower alkanols as hydrophilic co-component.
- 4. A composition of claim 3 wherein the hydrophilic co-component is ethanol.
- 5. A composition of to claim 1 in which the active ingredient is present in an amount of 1 to 15% by weight of the composition.
- 6. A composition of claim 1 in a soft gelatine encapsulated form.
- 7. A method of administering an antibiotic to a person in need of such treatment which comprises orally administering to said person a pharmaceutically effective amount of a composition of claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
9310974 |
May 1993 |
GBX |
|
9320463 |
Oct 1993 |
GBX |
|
Parent Case Info
This is a continuation of application Ser. No. 08/248,993, filed May 25, 1994 now abandoned.
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Continuations (1)
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Number |
Date |
Country |
Parent |
248993 |
May 1994 |
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