Patent Application
20050100566
The present invention relates to a topical gel composition.
Heretofore, gelled products have been utilized as topical agents or topical base agents in the fields of medicines, cosmetics, quasi-drugs, daily and sanitary miscellaneous commodities.
For example, they are utilized by optionally mixing pharmaceutical ingredients, etc., in gelled products, shaping the gelled products to a predetermined shape with or without supporting on a non-woven fabrics into a sheet-like configuration capable of sticking on human skins.
However, since undulations or creases are present on human skins and, further, since they expand and contract in accordance with motions, they are poor in the adaptability to human skins such as being peeled easily. Further, if the sheet of the gelled products is made into a thin film so as to conform to undulations and creases to endure expansion and contraction, their strength becomes extremely fragile such as suffering from puncturing or tearing during use.
Further, gelled products having self-shape retainability have been formed into a sheet with no support of a non-woven fabric or the like and used as topical agents.
However, even when they have self-shape retainability, when the gelled products are used alone, since the gelled products per se are fragile, the gel structure suffers from fracture or flexion by pressure upon taking out from a vessel or a package. Further, when they are peeled from the surface of human skins, they are torn by the tensile force, residues remain on the surface of human skins, or partial residues may contaminate the skin surface.
For solving the foregoing subject, an earnest study has been made on the properties of the gelled products, particularly, on the strength and the flexibility thereof and, as a result, it has been found unexpectedly that a gel composition comprising a water soluble polymer capable of enduring the use as a topical agent or a topical base agent with respect to strength or flexibility and having a further good handlability can be obtained when it has a predetermined water content and a compressive deformation ratio to accomplish the present invention.
It has further been found that a pad material more conforming to the human skins and optimal to various application uses can be obtained by the use of such a gel composition to accomplish the present invention.
The present invention provides a topical gel composition, formed of a water soluble polymer, having a self-shape retainability, 30 to 95% by weight of a water content and 65 to 99% of a compression deformation rate that expresses a maximum deformation rate till partial fracture of a gel structure when the gel composition is compressed at a predetermined speed by using a plunger capable of pressing at a predetermined speed.
Further, it provides a pad material in which the topical gel composition has a sheet-like and a rectangular or substantially rectangular shape and a positioning part is formed at the center.
Further, it also provides a blister vessel-filled type pad material in which a solution of the topical gel composition is filled in a blister vessel having a predetermined shape and formed into a sheet-like shape corresponding to the shape of the blister vessel, and a blister vessel filled type pad material in which the topical gel composition is formed into a sheet-like shape, cut into a predetermined shape and contained in a blister vessel.
The topical gel composition according to the invention mainly comprises a water soluble polymer.
The water soluble polymer has no particular restriction for the kind thereof so long as it shows the following water content and the compressive deformation rate when formed into a gel composition. Further, those which are transparent when prepared as a gel composition are preferred. Transparency means herein a state of colorless with no clouding which is so-called as water clear. The solubility of the water soluble polymer means such a property that 1 g of the water soluble polymer can be dissolved in about less than 30 ml of water at about room temperature.
For the water soluble polymer, natural water soluble polymer, particularly, polysaccharides are preferred. In a case of the natural water soluble polymers, those having a gel strength, for example, of about 60 to 100 g are suitable. The gel strength means herein a strength expressing, by the number of grams, a force necessary for pressing the surface of a gelled product of a water soluble polymer 4 mm down by a plunger at a rate of 6 cm/min. by using a rheometer, for example, having a plunger of 0.5 inch. Specific examples of natural water soluble polymers can include, for example, carrageenan, locust bean gum; xanthane gum; guar gum; gellan gum; tamarind seed gum; caraya gum; pectin; glucomannan, gelatin, etc.
Further, synthetic water soluble polymer may also be used and the average molecular weight in this case can include, for example, of about 1000 to 200,000,000. Specifically, they can include carboxy methyl cellulose, sodium carboxy methyl cellulose; carboxyvinyl polymer; polyvinyl alcohol, alginic acid, graft starch, agarose, polyglutamic acid, polyacrylic acid, alginic acid, honest gum or salts thereof and partially neutralized products thereof.
The water soluble polymer may be used alone or as a mixture of two or more of them. Among them, combination of two or more of them is preferred and use of natural water soluble polymers in combination of two or more of them is more preferred. Particularly, it is preferred that carrageenan is contained. Carrageenan is generally extracted from sea weed referred to Irish moss, which is a sort of a polysaccharides called as galactan containing sulfate groups which include κ, ι and λ types. In the present invention, any of them may be used, however, κ and/or ι types may be preferably used. In a case of using carrageenan, it is preferred that both of the κ type and the ι type are contained and the mixing ratio of carrageenan with other water soluble polymer is preferably, for example, about 1:0 (weight ratio) to 1:10 (weight ratio). Further, in a case of using both of the K type and the ι type, it is preferred that κ type:ι type=about 1:10 (weight ratio) to 10:1 (weight ratio). A further preferred specific combination is that of κ type and/or ι type carrageenan: locust bean gum: glucomannan, and the ratio of combination is about 10 to 1:10 to 1:1 (weight ratio) although not restricted particularly.
The water soluble polymer is appropriately contained by about 0.1 to 10% by weight based on the entire gel composition. It is preferably from 0.3 to 5% by weight, and more preferably about 0.5 to % by weight. The water soluble polymer is preferably edible. “Edible” means herein that drinking or eating is authorized by food regulating laws.
Further, the topical gel composition is formed by dissolving the water soluble polymer described above in water and gelling the same and has a water content of about 30 to 95%, preferably about from 40% or more, 50% or more, 90% or less, 85% or less and 80% or less. In a case where the water content is less than about 30%, it results in disadvantage such that the compressive deformation rate described later can not be obtained, water retainability is remarkably lowered, it tends to be defoliated from skins, results in drying of skin surface and skin eruptions. Further, if the water content exceeds 95%, the compressive deformation rate lowers remarkably making the gel composition brittle and no more sufficiently endurable to use, it shows remarkable release of water during use, worsens the handlability and tends to be defoliated from the skins as well.
Further, the compressive deformation rate of the topical gel composition is about from 65 to 99%, preferably, about 70% or more, 75% or more, 98.5% or less, 98% or less, 97% or less, 95% or less, 92% or less and 90% or less.
The compressive deformation rate is a maximum deformation rate, represented by percentage, till a gel structure reaches a partial fracture when a gel composition is compressed at a predetermined speed by using a plunger capable of pressing at a predetermined speed. More specifically, when the compressive deformation rate is measured, the gel composition is preferably a plate-like specimen of a predetermined thickness. Further, the plunger preferably has predetermined cross sectional area and such a plunger is generally assembled in a compression tester. Accordingly, the compressive deformation rate in the present invention can be measured by a compression tester. The specimen upon measurement is, appropriately, in a plate shape having, for example, a thickness of about 1 to 10 mm and, further, about 2 to 4 mm. As the compression tester, a texture meter for measuring feeling upon eating or a rheometer for measuring viscoelasticity can be usually used. The plunger preferably has a cross sectional area, for example, of about 0.1 to 2 cm2 and, further, a cross sectional area of about 0.5 cm2, and the shape is preferably of a substantially cylindrical shape. Further, the speed of the plunger is about from 0.01 to 0.1 mm/sec. and about at 0.05 mm/sec. Within the range of the compressive deformation rate, physical properties such as desired tensile strength and adaptability to predetermined undulations or creases can be attained, to obtain a gel composition of excellent handlability.
The gel composition according to the present invention can be obtained by dissolving a water soluble polymer in water in a range of temperature about from 60 to 90° C. and then allowed the solution to cool to About 20 to 40° C. thereby gelling the same. In this case, medicine (for example, anti-inflammatory agent, analgesic agent, itch killing agent, vitamin, etc.) or cosmetics (astringent, collagen, etc.) may be added as active ingredients, and additives used in the field of medicines, cosmetics and foodstuffs, for example, antiseptic agent, sterilizer, fragrances, colorants, anti-oxidants etc. may be added. Further, aroma oils, etc. used in aroma therapy may also be added.
Medicines can include, for example, menthol, camphor, indomethacine, ketoprophene, dichlorophenac, phellodendron bark extract, dipotassium glycyrrhizinate, hyaluronic acid, arbutin, tocopherol acetate, allantoin, vitamin C, water soluble azulene, acrinol, etc. These medicines can be used as granules coated with polymer film, or may be used being impregnated into and carried on porous polymer granules.
As aroma oils, essential oil ingredients (essential oils) generally used for aroma therapy may be used as they are. The essential oil ingredients can include those described, for example, in “84 Essential Oil Ingredients for Aroma Therapy”, written by Wander Celler, published from Fragrance Journal Co. Specifically, they can include those extracts, for example, from anise, angelica, benzoin, immortelle, chamomile, garlic, cardamon, galbanum, caraway, carrot seed, guaiac wood oil, grapefruit, cypress, cedar wood, star anise, sage, geranium, celery, thyme, estragon, turpentine, olibanum, violet, pine, parsely, fennel, black pepper, small leaved linden flower, lemon, lemongrass, rosemary, laurel leaf, meadowsweet, Japanese spirea, cornflower, almond, arnica, fennel, scotch broom, watercress, gentiana, camphor, plum, poire, Zizyphi fructus, dandelion, anemarrhenae, polyporus seed of wax gourd, rosa multiflora, peppermint, Fraxinus japonica, hoelen, merissa, peach, parasite, eucalyptus, coix seed, lavender, forsythia, etc.
As cosmetics and additives, those known in relevant field can be used.
The gel composition according to the invention can be used in the field of medicines, cosmetics, quasi-drugs, daily or sanitary miscellaneous commodities being sticked or in contact with human skins. Accordingly, the gel composition can be formed in the shape according to the application uses thereof. Specifically, they can include cooling sheets of an appropriate size for applying on foreheads, arms, legs, back, waist, joints and shoulders in the form of a sheet with a thickness of about 0.5 to 5 mm, a circular or elliptic face mask covering the entire face with a thickness of about 0.5 to 5 mm, a crescent-shaped or rectangular eye pack or lip pack with a thickness of about 0.5 to 5 mm, circular or rectangular itch-killing patch or pimple patch with a thickness of about 0.5 to 5 mm, gel sheet of various shapes for burn/sunburn/glowing with a thickness of about 0.5 to 5 mm, rectangular or cuboidal square cylinder or circular cylinder gel cake substrate.
The topical agents can be used as a gel composition not containing active ingredients or as a topical substrate containing active ingredients such as medicines or cosmetics therein. Further, they can be used together with a support such as non-woven fabric or may be used alone without using a support since they have self-shape retainability. In a case of forming the gel composition as a sheet-like, the cross sectional shape thereof may include various shapes such as elliptic, square, trapezoidal or inverted trapezoidal shape. Among them, a trapezoidal shape is preferred since peeling from skins can be prevented effectively when a surface with a large area in view of plane is sticked on human skins.
Particularly, the gel composition according to the present invention is used preferably as a pad material. While the pad material may be in various shapes depending on the application uses as described above, it preferably has, for example, a rectangular or substantially rectangular shape. The rectangular shape means herein a so-called laterally elongate shape in which corners thereof are not necessarily orthogonal but they may be rounded. This includes any shape in which the rectangular shape deforms while keeping its laterally elongate shape.
The pad material is preferably formed with a positioning part at the center thereof. The positioning part can include, for example, a concave recess or extension formed at the center of an upper edge or lower edge, or concave part, convex part, or a perforation formed on a vertical center line on the surface or the rear face.
The concave recess or extension has no particular restriction but it is preferably in such a shape that positioning is easy at the central portion of the pad material although not covering boarders of hair at the forehead, and the upper edge is preferably formed with a concave recess. Further, an extension is preferably formed to the lower edge for easy positioning by aligning with a portion between eyebrows although not covering eyebrows. The concave recess or the extension has, for example, a width of about 10 to 80 mm, preferably, about 10 to 50 mm, a depth or height of about 5 to 20 mm, preferably, 5 to 10 mm. Further, the concave recess or the extension is preferably formed with a curve, particularly, with a moderate curve so as to prevent tearing starting from the vicinity thereof.
The shape for the concave and convex parts has no particular restriction but it is preferably a shape easy for positioning. For example, it is preferred that the concave or convex part is formed to a height (depth) of about 1 to 3 mm and with a size of about 1 to 200 mm2 to either the surface or the rear face not in contact with human skins. In a case of a through hole, the size is preferably about 1 to 200 mm2.
The planar shape of the pad material is preferably an appropriate shape for applying, for example, to a face or a forehead as a cooling sheet. Specifically, it includes a square or corner-rounded square shape, or an elliptic or modified elliptic shape with the length for the longest vertical portion of about 40 to 90 mm and the length for the longest lateral portion of about 100 to 200 mm including the concave recess or extension to be described later.
Further, the pad material according to the present invention is preferably formed with a notch extending from the edge to the inside. The notch may be in any shape, size and number so long as it can deform the planar shape of the pad material corresponding to the shape of the application portion. For example, it is preferably in such a shape, size and number that can apply the pad material to an appropriate portion by pulling up or down the upper end of the pad material conforming to the shape of the boarder of hair on both ends of the forehead, the size of the forehead, etc. Specifically, it is preferably a slit-like shape or substantially trigonal shape with the width (maximum width) of about 1 to 5 mm and the length of about 10 to 40 mm. The position is appropriately at the peripheral edge of the sheet-like gelled product, for example, about ⅓ to ⅔ from top of the upper edge or both side edges. The notch may be arranged vertically to the side edge or the upper edge, or may be arranged being inclined at an angle of 30 to 90°. The number of the notches has no particular restriction and they may be formed by plurality to the edge and/or upper end but preferably formed each by one or two.
Further, the pad material according to the invention is preferably provided with a heat dissipation promoting portion for heat dissipation with an area of contact with external air being increased. For example, it is possible to form a heat dissipating through hole extending from the sticked surface to the opposite surface to form a heat dissipating concave part or groove on the surface opposite to the sticked surface, or to form a heat dissipating channel at an appropriate position in the thickness of the pad material.
Further, in the pad material according to the invention, for smooth movement of liquid at the inside, for effective evaporation of moisture content in the pad material through the heat dissipation promoting portion for heat dissipation, or for reinforcing the pad material per se, fibers which are hydrophilic at least on the surface are preferably dispersed inside the pad material. The fibers include, for example, pulp, fine fibrous cellulose, cotton threads, rayon and like other various hydrophilic resin fibers, as well as various hydrophobic resin fibers applied with hydrophilic treatment on the surface, glass fibers and ceramic fibers. The fibers are preferably dispersed such that they are entangled three dimensionally inside the pad material and exposed to the surface of the heat dissipating promotion portion for conducting heat dissipation by increasing the area of contact with external air.
Further, in the pad material according to the present invention, an adsorption concave part is preferably formed on the surface as an sticked surface or rear face. The concave part is evacuated in a case of sticking the pad material under pressing to the applying portion of a human body and sucked to the sticking portion. Even in a case that the amount of the gel composition is increased or the adhesion on the sticking surface is low, the pad material can be sticking stably to an sticked portion by means of the concave part.
Further, the pad material according to the invention is preferably formed such that the thickness at least a portion in the periphery is reduced toward the end edge. Thus, the pad material can be sticked along the applying portion which increases the ratio of area of the sticked surface relative to the amount of the gel composition and the pad material can be sticked stably to the applying portion even in a case of increasing the amount of the gel composition or in a case where the adhesiveness of the sticked surface is low. Particularly, when the thickness is reduced toward the side edge of the sticked surface for the entire periphery of the pad material, the pad material can be sticked more stably to the applying portion. Also, at least a portion in the periphery of the sticked surface may be reduced to the end edge of the surface opposite to the sticked surface. In the case of reducing the thickness toward the end edge, it is preferably reduced linearly or in a concave profile. Particularly, in a case of reducing the thickness in a concave profile, the pad material can be sticked to the applying portion more stably. In this case, since the strength is lowered on the end edge where the thickness is reduced, a reinforcing rib may be disposed to the end edge or the vicinity thereof on the surface opposite to the sticked surface.
In the pad material according to the invention, a support may be disposed to the surface or the rear face. The support has a size identical with or larger than that of the gelled pad. In a case of enlarging the support, it can be adhered to the applying portion by turning the support around the applying portion and engaging the ends of the support to each other, or by disposing a fixing adhesive layer to the outer edge of the support. Accordingly, even in a case of increasing the amount of the gel composition, the pad material can be fixed reliably to the applying portion by the support.
The pad material per se may also have a shape configurating the face or a body of an animal or a character so long as it does not impair each of the functions as will be described later.
The gel composition (or pad material) can be supplied being packed as an appropriate size or amount in a polyethylene bag or the like or in a blister package. In a case of containment in the blister package or the like, the blister package itself may be utilized for the molding of the gel composition, or a gel composition is cast into a predetermined shape to mold into a sheet-like shape, cut-out or punched into a desired shape, which may be contained in the blister vessel. In a case of molding and containment by using the blister package, etc., concave/convex portions may be preferably formed in the two-dimensional direction like a mesh-like shape to a region of the blister package other than the concave part in which the gel composition is to be contained. Thus, even in a case where the gel composition is formed into a large sheet-like shape, a flat sheet with no strain or distortion can be obtained.
Further, mesh-like shape or fine dot-shaped concave/convex pattern are preferably formed to the bottom of the concave part of the blister package. Then, upon molding the gel composition in the concave part, the concave/convex pattern develops to the surface of the gel sheet to cause random reflection making bubbles, etc. intruding into the gel composition not conspicuous. Further, a concave/convex part configurating the face or the body of an animal or the face or the body of a character, specifically, the face or the body of a dog, cat, pig, bear, elephant, etc., and the face or the entire body of a character such as Sazae-san, Doraemon, Anpanman, Astro Boy, etc., may be disposed for the concave part. This enables to obtain a pad material configurating an animal or a character by using the blister package for the pad material. Further, in a case of forming the blister vessel-filled type pad material containing a gel composition in a blister vessel, a support may be located on the surface or the rearface of the gel to be contained.
As the material for the blister vessel, a thermoplastic resin capable of injection molding, vacuum molding or pressure forming (for example, polypropylene, polyethylene terephthalate and polystyrene) is used preferably with no restriction to them. Further, material having light permeable or light screening property is preferably used in view of the property of the gel composition to be contained or various substances added to the gel composition. The blister vessel may be constituted with a single kind of resin, a lamination product of plural resin layers, or a lamination product of a resin layer with a metal layer or other layer. The thickness of the blister vessel is preferably set so as to have a mechanical strength endurable to the force exerted during wearing distribution and storage and it is for example, at 30 to 1000 μm in a case of using injection molding.
The pad material according to the present invention may be formed by using the specified gel composition according to the invention so as to have one or more features that (1) a positioning part is formed at the center, (2) a notch capable of deforming the planar shape is formed, (3) a heat dissipation promoting portion is formed, (4) an adsorption concave part is formed, (5) the thickness is reduced toward the end edge, and (6) the shape has a concave recess. So long as one or two of the features in view of the shape described above is provided, any gel composition may be used not restricted only to the specified gel composition described above. That is, it may be any of (1) a pad material in which the gel composition has a sheet-like and rectangular or substantially rectangular shape and a positioning apart is formed at the center, (2) a pad material in which the gel composition has a sheet-like or rectangular or substantially rectangular shape, and a notch extending from the edge to the inside and capable of deforming the planar shape conforming the shape of the applied portion, (3) a pad material in which the gel composition has a sheet-like and rectangular or substantially rectangular shape and a heat dissipation promoting portion for increasing the area of contact with external area and conducting heat dissipation is formed on the surface or the rear face, (4) a pad material in which the gel composition has a sheet-shape and a rectangular or substantially rectangular shape and an adsorbing concave part is formed to the surface or the rear face, (5) a pad material in which the gel composition is a sheet-like shape and the thickness for at least a portion in the periphery is reduced toward the end edge, or (6) a pad material in which the gel composition has a sheet-like shape and at least a portion of the peripheral edge has a concave recess curved smoothly to the inside and enhancing the adhesion of the entire peripheral edge of the sheet to the cured surface upon sticked to the curved surface.
Description is to be made to the examples of the topical gel composition, the pad material and the blister vessel-filled type pad material according to the invention.
Preparation of Gel Composition
Gel compositions were prepared according to the following prescriptions with respect to the total amount (100% by weight) of each gel composition.
In the above Examples 1-12, the common method for preparing each gel composition was as follows.
That is, a small amount of water was put in a vessel and a crosslinking agent was added to the water and dissolved therein. On the other hand, gel component such as κ-type carrageenan, ι-type carragreenan, locust bean gum, glucomannan, partially neutralized polyacrylic acid, etc. were added little by little to about a half amount of butylene glycol with stirring to obtain a liquid containing the gel components. (The gel components may be previously wetted and dispersed in a small amount of ethanol). Paraben was added to the remaining butylene glycol and completely dissolved with stirring under warming to give a solution. After cooling, the solution was added little by little to the above-mentioned liquid of the gel components with stirring.
Then, the mixture was added to the remaining water with stirring (in case where sorbitol is contained, sorbitol was also added thereto), and the gel components were swollen. The resultant swollen liquid of the gel components was heated to about 80-85° C. When the swollen gel components were homogeneously dissolved, the above aqueous solution of the crosslinking agent was added dropwise thereto, and the mixture was kept at 80-85° C. for about 30 minutes. Then, the mixture was cooled in a water bath controlled at 70-75° C. until the bubbles in the liquid were removed. Thus obtained hot solution for forming the gel composition was poured into a predetermined mold and left to stand at room temperature or cooled to room temperature to give a formed gel.
Compressive deformation rates of 12 kinds of the gel compositions obtained in the above Examples were measured. The measurement of the compressive deformation rate was carried out as follows. That is, a gel composition was compressed at a speed of 0.05 mm/sec. by using a compression tester, Texograph (Nihon Shokuhin Kenkyusyo) equipped with a cylindrical plunger having a cross sectional area of 0.5 cm2, and the compressive deformation rate just before the partial fracture of the gel composition was determined. The compressive deformation rate of a gel composition is an average value obtained from five samples.
A heated solution obtained in the same manner except for adding 0.05% by weight of 1-menthol to the preparation of Example 2 and dissolving menthol into a butylenes glycol solution in which parabene was dissolved was filled in a blister mold having a concave part with the maximum size for each of length, width and depth of about 4.5 cm×11 cm×4 mm and molded to obtain a cooling sheet.
When the cooling sheet was applied to a forehead, it kept a state sticked to the forehead even if a head was moved. Further, while it was sticked to the forehead for about 3 hours, cooling feeling was kept for the forehead. Further, upon peeling the cooling sheet from the forehead, it could be peeled neatly without flexing or breakage by pulling.
When a support made of a non-woven fabric is previously installed along the inner wall of the blister mold, a cooling sheet having a support on one surface can be obtained by filling the heated solution into the blister mold.
This can reinforce the cooling sheet per se and when the cooling sheet is applied to a forehead or the like, the support can be used as a fixing band by extending the support in the longitudinal direction and turning the support around the head.
A heated solution was prepared in the same manner as described above except for further adding 0.05% by weight of 1-menthol to the same preparation as that of Example 7 and dissolving menthol into a butylene glycol solution to which parabene was dissolved.
A gel ingredient comprising κ carrageenan, ι carrageenan, locust bean gum, glucomannan and a partially neutralized polyacrylic acid was added little by little while stirring thoroughly to about a half amount of butylene glycol to obtain a moistened liquid gel ingredient. Parabene and 1-menthol were added to the remaining butylene glycol and dissolved completely while stirring under heating to obtain a solution. After cooling, it was added little by little to the moistened liquid gel ingredient described above while stirring thoroughly. It was added to a predetermined amount of water while stirring thoroughly, to which sorbitol was added to swell the gel ingredient. The obtained swollen liquid gel ingredient was heated to about 85° C. and when the gel ingredient under swelling was dissolved homogeneously, a separately prepared aqueous solution of crosslinking agent was added dropwise under stirring and maintained at 85° C. for about 30 minutes. Then, it was immersed in a water bath controlled at 70 to 75° C. to lower the solution temperature and hold it till the bubbles in the solution were eliminated.
Thus obtained heated solution for forming the gel composition was filled in a blister vessel 11 as shown in
Since the cooling sheet 14 has a shape conforming to the upper edge of an eyebrow at the applying portion, the weight of the cooling sheet can be supported at this portion. Accordingly, the sticking ability can be satisfied sufficiently not only during laying down but also in active state such as during deskwork or walking. Further, since it has no support such as non-woven fabric as in the existent cooling sheet and since the cooling sheet itself is transparent, it gives no unwholesome appearance and can be used with no sense of discomfort even in an office room.
Further, in a case of forming the concave bottom of the blister vessel, for example, as a face of a dog as shown in
A heated solution of the same preparation as that of Example 2 was filled and molded in a blister mold with a thickness of about 2 mm and face sheets 20 and 21, 30 and 31, 40 and 41, and 50 and 51 having the shapes as shown in
When the face sheets were sticked over the entire face, they kept a state sticked to the face even when a head was moved. Further, when they were applied to the face, they favorably conform to the evenness of the face. Further, after sticking to the face for about one hour and peeling them, water retainability on the face was maintained. In addition, they could be peeled neatly by pulling upon peeling with no breakage.
Further, with the shape as shown in
Further, as shown in
A heated solution of the same preparation as that of Example 2 was filled and molded in a crescent shape blister mold having a length of about 10 cm, a width of about 2 cm and a thickness of 2 mm to obtain an eye pack.
When the face sheet was applied to the vicinity of eyes, it was kept at a state sticked in the vicinity of eyes even when the head was moved. Further, after sticking for about 3 hours to the vicinity of the eyes and then peeling, water retainability for the vicinity of eye was kept.
Vegetable collagen, trehalose, α-hydroxy acid or trimethylglycine was added by a slight amount to the preparation of Example 4 to prepare a heated solution.
The obtained solution was filled in a blister pack vessel 61 having a pair of crescent-shape concave parts as shown in
Since the eye pack 64 has a high compressive deformation rate, when it is taken out of the blister pack vessel 61, it had a sufficient compressive strength against gripping pressure even when the thickness was thin (for example, about 2 mm), and possessed a sufficient strength also against a tensile force exerting upon sticking to the vicinity of eyes or adjusting the position and, they were free from tearing, breaking, or cracking and extremely easy to handle with.
Further, after sticking, it was extremely excellent in the feeling of fitness due to the resiliency of the gel sheet and had sufficient adhesiveness irrespective of small close contactness.
Vegetable collagen, trehalose, α-hydroxy acid or trimethylglycin and olive oil were added in a slight amount to the preparation of Example 6 to prepare a heated solution.
The obtained solution was filled in a blister pack vessel 71 having a concave shape as shown in
Since the lip pack 74 had a high compressive deformation rate, it was not plucked, torn or cracked even upon taking out of the blister pack vessel 71 of a complicate concave shape and extremely easy to handle with. Further, it can be extended by pulling by both hands, is not broken even when extended into an extremely thin thickness and gives feeling of fitting when sticked in the thinned state to a lip. Further, a ridge 74a of the lip pack 74 is sticked to upper surface of a lower lip thereby capable of avoiding displacing downward slide, taking care of the lower lip substantially entirely, providing sufficient moistening to a dried lip while preventing drying thereof, and preventing cracking or the like.
Further, conversation is not hindered even during sticking of the pack due to a long slit 74b perforated through the lip pack 74.
Further, as a modified example, as shown in
A heated solution of a preparation of Example 10 was prepared to mold gel sheets shown in
In a gel sheet S1 shown in
In a gel sheet S2 in
A gel sheet S3 in
In a gel sheet S4 in
When the gel sheet is applied to skins suffering from smarting or itching feeling due to sunburn caused by sea bathing, etc. such symptoms can be mitigated. For example, as shown in
Further, as shown in
Further, as shown in
In the gel sheet S2 and the gel sheet S3, the size may be different between one concave recess and the other concave recess. Further, in the gel sheet S4, the concave recess 94a may be saved leaving the edge linear, or one or both of the concave recesses 94b and 94b may be omitted.
Since the gel sheet for treating sunburn/glowing has high compressive deformation rate, it extends effectively, can increase the area of adhesion by reducing the thickness and can be sticked over a wide range. Further, since the concave recess functions so as to conform to the curved surface of the body, the edge for the curved portion of the gel sheet sticked to the curved surface of the human skin is sticked snugly without raising from the skin, the peripheral portion is easily adhered over the entire circumference to the skins and is less peeled even movement of the body.
A heated solution prepared by adding 0.03% by weight of 1-menthol and 1% by weight of diphenhydramine hydrochloride to a preparation of Example 11 was filled in a blister pack vessel 101 of a disk-like shape (about 2 cm diameter, about 2 mm thickness) having plural concave parts shown in
Since the patch 104 for insect sting retains a sufficient amount of water content compared with the existent patch, it exhibits an excellent effect for preventing itching also with addition of cooling effect against inflammation.
A heated solution formed by adding 0.3% by weight of isopropylmethyl phenyl to a preparation of Example 12 was filled in a similar vessel to the disk-like blister pack vessel having several concave parts shown in
Since the patch for pimple is substantially transparent, it is not conspicuous when used for face or the like, and since it retains a sufficient amount of water content, it exhibits an excellent effect for preventing itchy feeling in addition to the cooling effect for inflammation.
A heated solution of the preparation of Example 6 was prepared, and a soft and flexible resin foam comprising open cells such as sponge was immersed in the solution to sufficiently absorb the solution into the open cells and then it was taken out to obtain a block-form gel cake substrate.
In the gel cake substrate, since a gel composition having a high compressive deformation rate is integrated with the soft and flexible resin form and since the gel composition effectively conforms the shrinkage of the resin foam, the gel composition is not crumbled from the resin foam.
Further, the block-form gel cake substrate can be used by property cutting into a sheet-like shape or a specified shape depending on the application use.
Further, for releasing water from the gel composition carried on the gel cake substrate, when an effective ingredient such as urea is blended or a potassium glycerin solution is used in place of water upon preparation to the gel composition, release of water from the gel composition is promoted upon shrinking under squeezing of the gel cake substrate and the effective ingredient can be discharged to prepare a gel cake effective for skin roughing.
A wound pad can be prepared by blending a sterilizing or bacteria static agent or effective ingredients to wounds.
Further, pad for bedsores can be prepared by blending a relatively great amount of succharide and an effective ingredient to wounds, for example, SHIUNKO, povidone-iodine.
0.03% by weight of 1-menthol was further added to the same preparation as Example 7 to prepare a heated solution, and a cooling sheet was formed in the same manner as in Application Example 2.
As shown in
Further, as shown in
As shown in
0.03% by weight of 1-menthol was further added to the same preparation as Example 7 to prepare a heated solution and a cooling sheet was formed in the same manner as in Application Example 2.
As shown in
In
For example, in a case of using the cooling sheet 220 or 230 shown in
0.03% by weight of 1-menthol was further added to the same preparation as Example 7 to prepare a heated solution, and a cooling sheet was formed in the same manner as in Application Example 2.
As shown in
Thus, water content in the pad material A1 is effectively evaporated through the through holes 313a to dissipate heat by the heat conducting from a human body to the pad material A1 thereby preventing warming of the pad material A1 and providing a sufficient cold insulation effect for a long time.
Further, for easy movement of liquid inside the pad material A1 and efficient evaporation of the water content in the pad material A1 through the through holes 313a, etc. to conduct heat dissipation, fibers 314 having hydrophilic property at least on the surface are dispersed inside the pad material A1 as shown in
Further, in order to prevent deposition of dusts or dirts to the surface 312 opposite to the sticked surface 311 of the pad material A1, or deposition of the surface 312 on the opposite side to other portion thereby defoliating the pad material A1 from the sticking portion, as shown in
Further, when a portable pad material making the pad material A1 portable is prepared, a vessel 320 comprising a containment concave part 321 having a planar shape corresponding to the planar shape of the pad material A1 and a flange 322 extended at the periphery for the opening of the containment concave part 321 is used as shown in
Then, as shown in
This suppresses evaporation of the water content from the pad material A1 by sealing with the airtight film 330 and it can be stored for long time, distributed and carried about in this state.
Further, in this constitution, since the pad material A1 engages the plural convex parts 323a, rattling of the pad material A1 in the vessel can be prevented and it can be distributed and carried about in a state of upstanding the vessel.
Then, in a case of using the pad material A1 sealed by the airtight film 330 in the containment concave part 321 of the vessel 320, the airtight film 330 is pulled and peeled from the flange 322 of the vessel 320 thereby opening the containment concave part 321 of the vessel 310, then pad material A1 is taken out from the inside of the containment concave part 321 of the vessel 320, and the sticked surface 311 of the pad material A1 is sticked to the forehead at the sticking portion.
Further, as shown in
0.03% by weight of 1-menthol was further added to the same preparation as Example 7 to prepare a heated solution, and a cooling sheet was formed in the same manner as in Application Example 2.
In the pad material A2, as shown in
The concave parts 313b may have a cross sectional shape, for example, as shown in
For manufacturing a portable pad material for enabling the pad material A2 to be carried about, as shown in
0.03% by weight of 1-menthol was further added to the same preparation as Example 7 to prepare a heated solution, and a cooling sheet was formed in the same manner as in Application Example 2.
As shown in
The cross sectional shape of the heat dissipating grooves 313c may be of a shape as shown in
0.03% by weight of 1-menthol was further added to the same preparation as Example 7 to prepare a heated solution, and a cooling sheet was formed in the same manner as in Application Example 2.
As shown in
0.03% by weight of 1-menthol was further added to the same preparation as Example 7 to prepare a heated solution, and a cooling sheet was formed in the same manner as in Application Example 2.
As shown in
Thus, the pad material A11 is sticked smoothly along the applying portion of the human body to increase the ratio of area of the sticked surface 411 relative to the amount of the gel composition and the pad material A11 can be sticked stably to the applying portion even in a case of increasing the amount of the gel composition or in a case where the adhesiveness at the sticked surface 411 is low.
In manufacturing a portable pad material for enabling the pad material A11 to be carried about, as shown in
In the vessel 420, the containment concave part 421 is formed to such a shape that the sticked surface 411 of the pad material A11 situates on the side of the opening of the containment concave part 421 and a peripheral wall 421b of the containment concave part 421 is formed so as to diverge convexly from the end edge at the bottom 421a to the opening of the containment concave part 421.
Then, as shown in
Further, in order that a finger or the like is kept from contact with the sticked surface 411 of the pad material A11 when the pad material A11 is taken out from the containment concave part 421 of the vessel 420, as shown in
Further, as shown in
0.03% by weight of 1-menthol was further added to the same preparation as Example 7 to prepare a heated solution and a cooling sheet was formed in the same manner as in Application Example 2.
As shown in
When a portable pad material for enabling the pad material A12 to be carried about is manufactured, as shown in
Further, the number, the shape, etc. of the sucking concave parts 417 formed on the sticked surface 411 of the pad material A12 have no particular restriction, and sucking concave parts 417 each of a conical shape, frusto conical shape or grooved shape may be disposed, for example, as shown in
Further, as shown in
According to the present invention, since the gel composition is formed of the water soluble polymer, has self-shape retainability, 30 to 95% by weight of the water content and the 65 to 99% of the compressive deformation rate, it is unexpectedly possible to prevent breaking, cracking and tearing during the handling of the gel composition and improve the strength and the handlability remarkably. In addition, since the gel composition per se can exhibit self-shape retainability with no support such as of a non-woven fabric, the adaptability can be enhanced more irrespective of the undulations, difference of curvatures and absence or presence of creases on the skin surface of a human body.
Particularly, in a case where the water soluble polymer constituting the gel composition is transparent, aesthetic appearance can be possessed or provided irrespective of the mode of use. Further, in a case where the water soluble polymer is edible, it can be used safely irrespective of the portion of use.
Further, in a case where the positioning part is formed to the pad material, it can be sticked being positioned to a forehead or the like easily without using a mirror or the like.
Further, in a case where notches are formed on both side edges, the material can be used being stretched or shrunk so as to conform the size of a forehead or a face accompanied by individual difference and it can be sticked appropriately to an appropriate portion.
Further, in a case of providing a heat dissipation promoting portion for dissipating heat by increasing the area of contact with external air, when heat is conducted from the human body or the like to the pad material, the water content and heat in the pad material can be evaporated and dissipated efficiently through the heat dissipation promoting portion thereby enabling to obtain sufficient cold insulation effect for a long time.
Furthermore, in a case where the sticked surface has sucking concave pads, when the pad material is urged to the applying portion of the human body, inside of the sucking concave part is evacuated, the pad material is sucked to the sticking surface of the human body and it can be sticked stably while preventing peeling.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2001-380343 | Dec 2001 | JP | national |
| 2002-79 | Jan 2002 | JP | national |
| 2002-3578 | Jan 2002 | JP | national |
| 2002-64089 | Mar 2002 | JP | national |
| 2002-101525 | Apr 2002 | JP | national |
| 2002-219095 | Jul 2002 | JP | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/JP02/12948 | 12/11/2002 | WO |
