Claims
- 1. A coating on the surface of cells, tissue, or a device for implantation into a patient comprising a boronic acid polymer crosslinked with a diol or carboxylic acid containing polymer or substrate.
- 2. The coating of claim 1, comprising alternating layers of the boronic acid containing polymer and a diol or carboxylic acid containing polymer.
- 3. The coating of claim 1 wherein the diol or carboxylic acid containing polymer is a water soluble polymer.
- 4. The coating of claim 1 wherein the diol or carboxylic acid containing substrate is the surface of the cells or tissue.
- 5. The coating of claim 1 wherein the substrate is the surface of a medical device.
- 6. The coating of claim 2 comprising at least five layers of polymer.
- 7. The coating of claim 1 further comprising an agent selected from the group consisting of therapeutic, prophylactic or diagnostic agents, coupled to or incorporated in, the polymer.
- 8. The coating of claim 1 wherein the boronic acid polymer comprising functional groups or domains modifying the polymer properties.
- 9. The coating of claim 8 wherein the polymer comprises biodegradable groups or domains.
- 10. A method for coating, encapsulating, plugging, sealing, or supporting a surface, comprising depositing a boronic acid polymer solution onto the surface, wherein the surface comprises diol or carboxylic acid groups which crosslink with the boronic acid polymer.
- 11. The method of claim 10 further comprising coating the surface with a diol or carboxylic acid containing polymer prior to depositing the boronic acid polymer solution thereon.
- 12. The method of claim 10 further comprising applying to the boronic acid polymer a layer of a diol or carboxylic acid containing polymer to form a multi-layer structure.
- 13. The method of claim 12 further comprising alternately repeating the steps of depositing the boronic acid containing polymer and applying the diol or carboxylic acid containing polymer to form additional layers of the multi-layer structure.
- 14. The method of claim 10, wherein the boronic acid polymer is applied to cell or tissue surfaces to minimize or prevent tissue adhesion.
- 15. The method of claim 14 wherein the polymer is applied postoperatively, or during angioplasty, to minimize or prevent postoperative adhesion, thrombosis, or to encourage healing or prevent infection.
- 16. The method of claim 14 wherein the polymer has coupled to or incorporated therein an agent selected from the group consisting of therapeutic, diagnostic or prophylactic agents, comprising applying the polymer to a site for delivery of the agent.
- 17. The method of claim 10 wherein the polymer is applied to the surface of a medical device.
- 18. The method of claim 10 comprising applying the polymer to cancer cells to seal and encapsulate the seals to minimize metatasis of the cells.
Parent Case Info
[0001] This application claims priority to U.S. Ser. No. 60/098,040 filed Aug. 27, 1998.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60098040 |
Aug 1998 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09384888 |
Aug 1999 |
US |
Child |
10035625 |
Dec 2001 |
US |