Claims
- 1. A cyclopropane compound having the formula: ##STR23## or any pharmaceutically acceptable salt thereof, in which X is a halogen atom;
- R.sub.1 is a hydrogen;
- R.sub.2 is a hydroxyphenyl; and
- R.sub.3 is a cyclopentyl group having the first position carbon and the fifth position carbon bonded to the same carbon of the cyclopropane wherein the R.sub.4 group is absent.
- 2. The compound of claim 1 in which X is chlorine.
- 3. A composition of matter comprising a compound having the formula: ##STR24## or any pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier of sufficient quantity to solubilize the compound, in which:
- X is a halogen atom;
- R.sub.1 is a hydrogen;
- R.sub.2 is a hydroxyphenyl; and
- R.sub.3 is a cyclopentyl group having the first position carbon and the fifth position carbon bonded to the same carbon of the cyclopropane wherein the R.sub.4 group is absent.
- 4. A method of increasing uterine growth in a mammal comprising administering to the mammal an effective amount of one or more of the compounds having the formula: ##STR25## or any pharmaceutically acceptable salt thereof, in which X is a halogen atom;
- R.sub.1 is a hydrogen;
- R.sub.2 is a hydroxyphenyl; and
- R.sub.3 is a cyclopentyl group having the first position carbon and the fifth position carbon bonded to the same carbon of the cyclopropane.
- 5. The method of claim 4 in which X is chlorine.
- 6. The method of claim 4 wherein the compound further comprises a pharmaceutically acceptable carrier of sufficient quantity to solubilize the compound.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of Ser. No. 07/812,246, filed Dec. 19, 1991, now abandoned entitled "DIPHENYLCYCLOPROPYL ANALOGS AS ANTIESTROGENIC AND ANTITUMOR AGENTS", which is a continuation-in-part of Ser. No. 07/432,564, filed Nov. 6, 1989, now U.S. Pat. No. 5,098,903, which is a continuation-in-part of Ser. No. 07/098,945, filed Sep. 21, 1987, now U.S. Pat. No. 4,879,315, which is a continuation-in-part of Ser. No. 06/363/429, filed Mar. 30, 1982, now abandoned, which is a continuation-in-part of Ser. No. 06/166,255, filed Jul. 7, 1980, now abandoned, which is a continuation-in-part of Ser. No. 06/128,040, filed Mar. 7, 1980, now abandoned.
GOVERNMENTAL SUPPORT FOR INVENTION
This invention was made with Government support under a grant from the National Institutes of Health (CA 40458). The Government has certain rights in this invention.
Non-Patent Literature Citations (5)
Entry |
Madeddu et al., "A New Method for Evaluating the Inhibiting Potency of Antiestrogens on Breast Cancer Cell Lines", Anticancer Research, 6: 11-16, (1986). |
Griffin et al., "Synthesis and Biological Evaluation of a Series of Gem-Dichlorocyclopropanes as Antitumor Agents", Anti-Cancer Drug Design, 7: 49-66, (1992). |
Hausser et al., J. Org. Chem., 37:4087-4090, (1972). |
Magarian et al., J. Pharmaceutical Sciences, 61: 1216-1219, (1972). |
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Continuation in Parts (6)
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Number |
Date |
Country |
Parent |
812246 |
Dec 1991 |
|
Parent |
432564 |
Nov 1989 |
|
Parent |
98945 |
Sep 1987 |
|
Parent |
363429 |
Mar 1982 |
|
Parent |
166255 |
Jul 1980 |
|
Parent |
128040 |
Mar 1980 |
|