GENCODE Resource Project

Information

  • Research Project
  • 9980964
  • ApplicationId
    9980964
  • Core Project Number
    U41HG007234
  • Full Project Number
    5U41HG007234-08
  • Serial Number
    007234
  • FOA Number
    PAR-14-191
  • Sub Project Id
    7902
  • Project Start Date
    -
  • Project End Date
    -
  • Program Officer Name
  • Budget Start Date
    6/1/2020 - 4 years ago
  • Budget End Date
    5/31/2021 - 3 years ago
  • Fiscal Year
    2020
  • Support Year
    08
  • Suffix
  • Award Notice Date
    9/11/2020 - 4 years ago

GENCODE Resource Project

RESOURCE PROJECT - PROJECT SUMMARY A comprehensive knowledge of the location, structure, and expression of genes in the human genome is central to the understanding of human biology and the mechanisms of disease. Similarly for mouse, a comprehensive high quality gene set will aid in the design of experiments, and the interpretation of the effects of gene knockouts and resulting phenotypes, and as a model for human disease will help inform human gene function. The GENCODE consortium has assembled a team of world experts in a variety of fields related to gene annotation to create and distribute this gold standard. GENCODE's wide expertise covers gene and transcript isoform identification, pseudogene evolution, sequence conservation, gene expression, proteomics and post-translational modifications, gene regulatory elements, development and maintenance of the infrastructure required to create genome annotation at scale, and demonstrated community engagement and leadership. The complete and accurate annotation of the human and mouse genomes is necessary as many of the protein-coding genes are still incomplete or misannotated. GENCODE also aims to include all non-protein-coding genes which remain poorly understood with many loci still missing. Beyond the coding and non-coding genes, GENCODE creates reference pseudogene annotation as recent studies indicate that pseudogenes can play key regulatory roles. The completion of the full first-pass manual annotation of the reference mouse genome assembly will therefore be one of the main objectives of GENCODE. Efforts are underway in the Genome Reference Consortium (GRC) to expand the definition of the reference human genome to include genomic sequence for all haplotypes and gene alleles. GRC have already committed to supporting the genomes of a collection of 16 representative mice strains, thus effectively replacing the linear genome with a ?graph-like? structure of 16 separate haplotypes. GENCODE already annotate the full reference genome for human and mouse, including all available alternate sequences. GENCODE will continue to provide annotation appropriate to these new genomic sequences. In addition to genomic mutations that impair gene product function, many phenotypes are caused or moderated by the regulation of gene products. Therefore, GENCODE's complete annotation of all transcript isoforms logically includes key regulatory regions that are fundamentally a part of each gene and GENCODE will pilot the annotation of these tissue-specific regions.

IC Name
NATIONAL HUMAN GENOME RESEARCH INSTITUTE
  • Activity
    U41
  • Administering IC
    HG
  • Application Type
    5
  • Direct Cost Amount
    1030867
  • Indirect Cost Amount
    38449
  • Total Cost
  • Sub Project Total Cost
    1069316
  • ARRA Funded
    False
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
    NHGRI:1069316\
  • Funding Mechanism
    RESEARCH CENTERS
  • Study Section
    ZHG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    EUROPEAN MOLECULAR BIOLOGY LABORATORY
  • Organization Department
  • Organization DUNS
    321691735
  • Organization City
    HEIDELBERG
  • Organization State
  • Organization Country
    GERMANY
  • Organization Zip Code
    69117
  • Organization District
    GERMANY