Gene expression profiles being predictive for the response of tumors to pharmaceutically effective compounds

Information

  • Patent Grant
  • 8691506
  • Patent Number
    8,691,506
  • Date Filed
    Thursday, April 13, 2006
    18 years ago
  • Date Issued
    Tuesday, April 8, 2014
    10 years ago
Abstract
The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, the use thereof, a microarray wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of said gene expression profile, and a diagnostic kit containing said microarray.
Description

This application is a section 371 U.S. National phase application of international application no. PCT/EP2006/003421, filed Apr. 13, 2006, which claims the benefit of priority to EP application no. 05008088, filed Apr. 13, 2005 and U.S. Provisional application No. 60/670,863, filed Apr. 13, 2005.


The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, the use thereof, a microarray wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of said gene expression profile, and a diagnostic kit containing said microarray.


Gene expression profiles reflect the relative expression level of transcription units by determining the amount of mRNA expressed. Changes in the expression levels of genes up- or down-regulated in cancerous cells can be determined when comparing the gene expression profile of highly and moderately responsive tumor tissue with the gene expression profile of resistant tumor tissue.


The so-called microarray analysis is a useful method for a highly efficient analysis of gene expression profiles. A microarray is an ordered array of genes immobilized on a planar substrate that allows the specific binding of labeled nucleic acids. Microarray technologies which can be used for analyzing gene expression profiles involve depositing nucleic acids on a solid platform in a set pattern, and hybridizing a solution of complementary nucleic acids to the nucleic acid targets. Microarray technology has been applied increasingly in this field due to its capability to illustrate the cancerous changes in the cellular behavior on a genomic level.


One of the main problems when identifying genes which predict the treatment-response of an individual tumor is the lack of a sufficient large number of different tumors being characterized for both their chemosensitivity and mRNA expression. Cell lines and cell line derived xenografts do not have enough predictive capabilities for a clinical use for evaluating genes in question. In investigating tumors only a few pharmaceutically effective compounds can be evaluated in a single tumor model and today most tumor types are treated with combination chemotherapy.


In the prior art methods for obtaining gene expression profiles of tumor material are established for one individual tumor type and are not transferable to other tumor types. Further, most of the methods known in the prior art use a two sided t-test to choose the genes differentially expressed in only two classification groups for the responsiveness of a tumor to the treatment with a pharmaceutically effective compound, i.e. sensitive and resistant. The main drawback of this method is the fact, that this procedure has a high risk of getting a large number of “false positive” genes which are differentially expressed in the different groups only by chance.


Thus, the technical problem underlying the present invention is to provide a new method for predicting the responsiveness of an individual tumor to a pharmaceutically effective compound.


The solution to the above technical problem is achieved by the embodiments characterized in the claims.


In particular, the present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, comprising the steps of

    • (a) xenotransplanting human tumor material of at least five different tumors into at least one suitable test animal, preferably a nude mouse,
    • (b) determining the gene expression profiles of the resulting tumor xenografts,
    • (c) treating said at least one test animal with a pharmaceutically effective compound,
    • (d) evaluating the responsiveness of the tumor xenografts to the pharmaceutically effective compound,
    • (e) identifying the gene expression profile of each of the tested tumor xenografts, and
    • (f) determining the predictive genes in the gene expression profiles by comparing the gene expression profiles of the responsive tumors, the no-change tumors and the progressive tumors.


According to the present invention, the human tumor material being xenotransplanted into at least one suitable test animal, preferably a nude mouse, can be any human tumor material, e.g. derived from bladder, breast, colon, CNS, head and neck, liver, gallbladder, lung (small cell and non small cell), kidney, ovarian, pancreas, pleura, prostate, stomach, testicle, and uterus tumors, sarcomas, melanomas, and lymphomas. In a preferred embodiment of the present invention tumor material derived from different tumor types is transplanted into at least one nude mouse in step (a) of the above method, so that the predictive genes determined in step (f) of the above method are found in gene expression profiles of different tumor types.


In a preferred embodiment of the present invention each different tumor is xenotransplanted into one suitable test animal. For example, human tumor material of at least 15, more preferably at least 30, most preferably from 30 to 50 different tumors are each xenotransplanted into a different test animal, thereby resulting in at least 15, more preferably at least 30, most preferably from 30 to 50 different xenotransplanted test animals, preferably nude mice.


In a preferred embodiment of the present invention the human tumor material being xenotransplanted into the at least one test animal is derived from the tumor types shown in Table 2.


The term “xenografts” as used herein means patient-derived human tumor xenografts which have never been transformed into a cell line and have always been passaged directly into and through test animals, preferably nude mice. They have proven to have a high capability of predicting chemosensitivity to anti-cancer agents regarding the clinical situation of patients. For this reason they are a preferred choice for acquiring chemosensitivity data and gene expression profiles for the corresponding tumor samples.


The term “gene expression profile” as used herein refers to the relative expression of a plurality of mRNA transcripts or post-transcriptional level including protein amounts and post-translational modifications. A gene expression profile of a human tumor xenograft or a human tumor tissue reflects the amount of each mRNA transcript and/or post-transcriptional level in the starting sample. In a preferred embodiment of the present invention the gene expression profiles of the tumor xenografts is obtained using e.g. microarray techniques, PCR, Northern-analysis, etc.


The evaluation of the responsiveness of the tumor xenografts to the pharmaceutically effective compound has been carried out by determining the T/C (therapy/control) values of each tumor. The T/C value of each tumor can be determined by comparing the size of a tumor treated with a pharmaceutically effective compound (therapy) with the size of the untreated tumor (control). After all measurements at various time points are carried out the minimal value representing the best compound effect is taken for evaluation. If for example a tumor treated with a pharmaceutically effective compound has 20% of the size of an untreated tumor then the respective T/C value of the tumor treated with a pharmaceutically effective compound is 20% which equals to a tumor growth inhibition property of said pharmaceutically effective compound of 80%.


In preferred embodiments of the present invention a tumor xenograft is considered to be responsive when its T/C (therapy/control) value is e.g. less than 25%, a tumor xenograft is considered to be no-change when its T/C value is e.g. 25% or more and e.g. 42% or less, and a tumor xenograft is considered to be progressive when its T/C (therapy/control) value is e.g. more than 42%. In contrast to the prior art the present invention uses three groups which is much closer to the clinical situation than only using two.


In order to determine the predictive genes at least two of the groups selected from the group consisting of responsive, no-change, and progressive tumors, have to comprise more than one tumor as a minimum prerequisite for carrying out the Anova-test. Thus, the minimum prerequisites for determining the predictive genes are for example two responsive tumors, two no-change tumors, and one progressive tumor, or two responsive tumors, one no-change tumor, and two progressive tumors, or one responsive tumor, two no-change tumors, and two progressive tumors.


The health conditions of the animals used for xenotransplantation in the method according to the present invention is significantly impaired due to tumor growth. Accordingly, the life span of the test animals used for xenotransplantation in the method of the present invention is significantly shortened when compared to test animals not used in the method of the present invention. Therefore, the test animals either are sacrified early due to large tumor burden of the xenotransplanted tumor material or are killed after the completion of the method according to the present invention.


In a preferred embodiment of the present invention step (f) of the above method comprises a step of filtering out the relevant genes before the determination of the predictive genes.


In a further preferred embodiment of the above method step (f) comprises the steps of

    • (i) dividing the complete set of gene expression profiles of the tumor xenografts into sub-sets, each of the sub-sets missing one of the gene expression profiles,
    • (ii) determining the predictive genes in each sub-set, and
    • (iii) obtaining the gene expression profile being predictive for the specific response of an individual tumor to the pharmaceutically effective compound by setting up the intersection of the predictive genes of all sub-sets.


In this embodiment the step of determining the predictive genes comprises a leave-one-out cross-validation. In k-fold cross-validation, the data is divided into k subsets of (approximately) equal size. The net is trained k times, each time leaving out one of the subsets from training, but using only the omitted subset to compute whatever error criterion is of interest. If k equals the sample size, this is called “leave-one-out” cross-validation.


Determining a list of predictive genes by taking the intersection of the n-gene-lists (each containing the 300 most specific genes), the risk of false positives is minimized due to the fact that “a gene by chance” would have to be a “false positive by chance” in any of the n-gene-lists, being much more improbable than using the procedures of the prior art. The “leave-out-method” of the present invention to get the predictive genes will also lead to a list of predictive genes, not biased by the tumor later left out in the cross-validation method since each gene which is only predictive because of a single tumor in the training-set will be discarded by using the intersection of the n-gene-lists.


In addition, combining an Anova test with the Fisher's Exact Test in the process of setting up the n-gene-lists is a promising way to get the 300 most specific genes for every time another tumor is left out.


It should be noted that cross-validation is quite different from the “split-sample” or “hold-out” method that is commonly used. In the split-sample method, only a single subset (the validation set) is used to estimate the generalization error, instead of k different subsets; i.e., there is no “crossing”.


The distinction between cross-validation and split-sample validation is extremely important because cross-validation is markedly superior for small data sets; this fact is demonstrated dramatically by Goutte (1997) in a reply to Zhu and Rohwer (1996). For an insightful discussion of the limitations of cross-validation choice among several learning methods, see Stone (1977).


In a more preferred embodiment of the present invention the expression profile of 300 genes is determined for each sub-set when determining the predictive genes in each sub-set.


In another preferred embodiment of the present invention the gene expression profile is validated by a leave-one-out cross-validation.


The pharmaceutically effective compound according to the present invention can be any pharmaceutically effective compound known in the art and/or commercially available for the treatment and/or prevention of cancerous diseases. This includes pharmaceutically effective compounds containing agents effective for preventing tumor growth and/or metastasis or for reducing tumor size. Examples of such agents are angiogenesis inhibitors, including inhibitors of endothelial cell proliferation, e.g. Angiostatin K1-3, Avastin, Endostatin, Fumagillin, and Minocycline EGFR inhibitors, e.g. Cetuximab, and inhibitors of the biosynthesis of TNF-α, e.g. Thalidomide. Further examples of such agents are DNA intercalators/cross-linkers, e.g. Bleomycin, Chlorambucil, Melphalan and Oxaliplatin, DNA synthesis inhibitors, e.g. Aminopterin, 5-Fluoro-5′-deoxyuridine, 5-Fluorouracil, Gemcitabin, Ganciclovir, and Hydroxyurea, Capecitabin, DNA-RNA transcription regulators, topoisomerase II inhibitors, e.g. Actinomycin D, Daunorubicin, Doxorubicin, and Idarubicin, enzyme inhibitors, e.g. Curcumin, Etoposide, and Trichostatin A, agents causing demethylation of the DNA, e.g. 5-Aza-2′-deoxycytidine and 5-Azacytidine, agents having an antiproliferative effect, e.g. Cholecalciferol, microtubule inhibitors, e.g. Colchicine, Docetaxel, Nocodazole, Paclitaxel, Vinblastine, Vincristine, Vindesine, and Vinorelbin, and apoptosis causing agents, e.g. Troglitazone and Thapsigargin. In a preferred embodiment of the present invention the pharmaceutically effective compound is Avastin, a VEGF inhibitor.


In a more preferred embodiment of the present invention, the pharmaceutically effective compound is Avastin and the human tumor material being xenotransplanted into the test animals is derived from colon, non small cell lung, breast and/or renal tumors.


In a particularly preferred embodiment of the present invention the pharmaceutically effective compound is Avastin and the predictive genes of the gene expression profile obtained by the above method consists of genes characterized by SEQ. ID. No. 1 to SEQ. ID. No. 118.


In another preferred embodiment of the present invention the present invention the pharmaceutically effective compound is Avastin and the predictive genes of the gene expression profile obtained by the above method consists of genes characterized by the sequences shown in Table 3.


It is a further object of the present invention to provide a use of a gene expression profile obtained by the above method in the manufacture of a medicament carrying out an individual, tumor-specific diagnosis or treatment of a cancerous disease.


Another object of the present invention is the provision of a method for predicting the responsiveness of an individual tumor to a treatment with a pharmaceutically effective compound comprising the steps of

    • (a) providing a gene expression profile obtained by the above method,
    • (b) determining the gene expression profile of the tumor to be treated, and
    • (c) comparing the gene expression profile of step (a) with the gene expression profile of step (b).


Using the above method it is possible to predict the prospect of success of a treatment of a patient suffering from a cancerous disease. Therefore, the above method can be used to avoid unnecessary treatment with chemotherapeutics which are a great physical and psychological burden on a tumor patient. Thus, the above method is useful for optimizing the individual treatment of a cancerous disease and avoiding the costs and serious side-effects of an ineffective chemotherapy.


In a preferred embodiment of the present invention the gene expression profiles of the tumor to be treated is obtained using microarray techniques.


The present invention also relates to the use of Avastin for a gene expression profile-dependent treatment of a cancerous disease. Avastin may e.g. be used in the treatment of a patient having a tumor, wherein the dosage of Avastin has been lowered or increased depending on the gene expression profile of said tumor when compared to the dosage which would have been used in the treatment of said patient without obtaining the gene expression profile of said tumor. In a preferred embodiment of the present invention, the gene expression profile-dependent treatment of a cancerous disease is a combination therapy comprising the use of at least one other pharmaceutically effective compound. In a more preferred embodiment of the present invention the decision whether Avastin is to be used in said combination therapy is dependent on the gene expression profile of the tumor to be treated. In a most preferred embodiment of the present invention the decision whether Avastin is to be used in said combination therapy is dependent on a gene expression profile consisting of the genes listed above.


The present invention also relates to a microarray, wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of a gene expression profile obtained by the method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound of the present invention.


The term “microarray” as used herein means any arrangement of biomolecules, such as nucleic acids, antibodies, preferably oligonucleotides in addressable locations on a substrate resulting in a so-called “biochip”. The substrate may be any substrate suitable for use in a microarray known in the art, like e.g. membranes, glass, plastic, silicon wafers, and metal alloys. The information obtained when using microarray techniques can also be obtained by other methods known in the art for determining gene expression profiles, e.g. PCR, Northern-analysis, etc.


It is a further object of the present invention to provide a diagnostic kit containing the above microarray.





The figure shows:



FIG. 1 shows a flowchart which gives an example of a preferred embodiment how the method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound according to the present invention may be carried out. sd: standard deviation.



FIG. 2 shows an overview of a preferred embodiment how the method for providing a gene expression profile being predictive for the specific response of an individual tumor to Avastin as described in Example 1 may be obtained.





The present invention will now be further illustrated in the following examples without being limited thereto.


EXAMPLES
Example 1

The activity of Avastin has been tested against a set of 46 of patient derived tumor xenografts in nude mice derived from different tumor types preferably known to have the chance of being responsive to Avastin e.g. colon, non small cell lung, renal, or breast cancers. The gene expression profiles for the same tumors have been obtained by using the Affymetrix gene-expression Arrays HG-U133A/B and HG-U 133 Plus 2.0. These gene expression arrays determine the expression of about 34,000 genes.


For identifying genes, being predictive for the specific response of an individual tumor to a specific compound, the following steps are carried out, starting with a list of all gene expressions determined by the arrays:

  • (1) Every gene expression that has a value of lower than 0.01 was set to 0.01 to make natural log transformation for further statistical analysis possible.
  • (2) Every gene expression on a single chip was normalized to the median of the “not absent” genes being described by Affymetrix as “positive control genes” to make an inter-chip comparison possible and eliminate non-biological variances.
  • (3) All genes with an “absent” status in all tumor samples were removed from the list.
  • (4) All genes with a standard deviation of greater or equal 0.75 in at least one of the classification-groups (R, NC, P) were removed because they are not supposed to be predictive for the groups.


After these “quality filtering” steps the main determination of predictive genes is carried out:

  • (1) The training-set of the 46 tumor samples is divided into 46 sub-training-sets, each of these sub-training-sets missing one, different tumor.
  • (2) A list of 300 genes with the highest classification group specificity is determined for each sub-training-set.


Each gene in this list has to fulfill the following requirements:

    • having a raw signal of at least 30 in at least (46−1)/4 which equals about 11 tumor samples, and therefore being expressed in at least ¼ of all tumors above a critical level of background.
    • having a “specificity rank” of ≦300 with the specificity rank defined by:
    • specificity rank=1/(p-val+1/Fish.Rank) with
    • p-val determined by a Welch ANOVA test across the classification-groups
    • Fish.Rank determined by the Hypergeometric Fisher's Exact Test.


The procedure carried out for all 46 sub-training-sets, results in 46 lists of 300 genes respectively. By setting up a gene-list containing the intersection of all these 300 gene containing lists, the result is a set of genes which were specific in all sub-training-sets and is not dependent on a single tumor sample. This step minimizes the risk of “false positive” genes, which otherwise could have been wrongly identified as being specific/predictive.


The final outcome is a list of 118 gene expression in 46 tumors (Table 1, horizontal: different tumors tested, vertical: Affymetrix genes) which is predictive for the response of these tumors to Avastin. The tumor types used determining said gene profile are shown in Table 2 and the sequences of the predictive genes are shown in Table 3. The gene signature is validated by a “leave-one-out cross-validation” using e.g. either a “k-nearest neighbours” or a “support vector machine” classification algorithm.


After validation, the gene expression profile can be used for further prospective validation or to predict tumor samples with unknown chemosensitivity. Using e.g. a “support vector machine” of order 1 for a “leave-one-out cross-validation” showed that the detected genes have a very good ability to discriminate the tumors into the three classification groups and predict tumor response to Avastin (FIG. 2).


Methods


It should be noticed that k-nearest neighbours and support vector machines are available in the prior art.


A. Welch Anova (Parametric)


Let i index over the G groups formed by distinct levels of the comparison parameter.


Let Xik be the expression values, with k running over the replicates for each situation, interpreted according to the current interpretation (ratio, log of ratio, fold change).


Let:


Ni=the number of non-missing data values for each group,








X
_

i

=


1
/

N
i







k
-
1


N
i








X
ik








be the group means, and







SS
i

=




k
-
1


N
i









(


X
ik

-


X
_

i


)

2







be the within-group sum of squares.


In all calculations, missing values (No Data) or (NaN) are left out of the sums, not propagated. If any of the Ni are zero, drop that parameter level from the analysis, and readjust G accordingly. If G is not at least 2, exit (p-value=1).


First, it has to be checked that each group has Ni greater than or equal to 2 and SSi greater than 0. If not, remove it from consideration and recompute G. If G is not at least 2, exit (p-value=1). (This reflects the more stringent requirements of not assuming the variances equal—if the variance estimate is pooled, replicates are only needed for at least one group, if variances are separately estimated then replicates are needed for each group.) Then compute:







w
i

=


N
i



(



N
i

-
1


SS
i


)







the group weights






W
=




i
-
1

G







w
i







the sum of weights







X
~

=





i
-
1

G




w
i








X
_

i



W






the weighted mean

    • BSS=Σwi( Xi−{tilde over (X)})2 the between-groups sum of squares
    • d1=G−1 the numerator degrees of freedom
    • BMS=BSS/d1 the between groups mean square






Z
=


1


G
2

-
1







i
=
1

G









(

1
=


w
i


W
_



)

2

/

(


N
i

=
1

)













d
2

=

1

3






Z
_








the denominator degrees of freedom

    • if d2 is not greater than zero, then exit (p-value=1).
    • WMS=1+2(G−2)Z the within-group. mean square
    • W=BMS/WMS the test statistic


The (approximate) p-value is calculated by looking up W in the upper tail probability of an F distribution with d1 and d2 degrees of freedom. Note that d2 will not, in general, be an integer.


B. Fisher's Exact Test:


Fisher's Exact Test looks for an association between expression level and class membership. Each gene is tested for its ability to discriminate between the classes. Genes with the lowest p-values are kept for the subsequent calculations.


In this method, all the measurements for a given gene are ordered according to their normalized expression levels. For each class (parameter value), the predictor places a mark in the list where the relative abundance of the class on one side of the mark is the highest in comparison to the other side of the mark. The genes that are most accurately segregated by these markers are considered to be the most predictive. A list of the most predictive genes is made for each class and an equal number of genes (lowest p-value using Fisher's Exact Test) are taken from each list.



















TABLE 1









CXF_975,
LXFA_297,

LXFE_409,
LXFL_430,
MAXF_1322,
MAXF_1384,
MAXF_401,




CXF_264, Avastin_p
Avastin_p
Avastin_p
LXFA_923, Avastin_p
Avastin_p
Avastin_p
Avastin_p
Avastin_p
Avastin_p
MAXF_583, Avastin_p



NC
NC
NC
NC
NC
NC
NC
NC
NC
NC


Systematic Name
normalized
normalized
normalized
normalized
normalized
normalized
normalized
normalized
normalized
normalized





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0.0514
0.0633


221214_s_at
0.0469
0.0362
0.0209
0.0241
0.0427
0.0293
0.0485
0.0255
0.0471
0.0434


221249_s_at
0.038
0.0774
0.0849
0.064
0.261
0.0781
0.0578
0.0993
0.0317
0.0717


222587_s_at
0.0831
0.0866
0.143
0.062
0.0315
0.0293
0.0233
0.0244
0.0305
0.01


222612_at
0.0212
0.0881
0.042
0.101
0.0722
0.0976
0.0934
0.0952
0.0722
0.156


222775_s_at
0.0993
0.104
0.106
0.121
0.0848
0.137
0.0989
0.0893
0.175
0.103


222807_at
0.0254
0.0697
0.0395
0.0784
0.0951
0.0781
0.0975
0.0685
0.101
0.122


222906_at
0.154
0.131
0.17
0.126
0.246
0.169
0.211
0.217
0.249
0.133


223175_s_at
0.0882
0.0637
0.0642
0.0767
0.111
0.0846
0.0687
0.0673
0.13
0.0861


223197_s_at
0.194
0.194
0.0913
0.22
0.117
0.111
0.187
0.149
0.127
0.17


223206_s_at
0.264
0.22
0.178
0.127
0.198
0.163
0.187
0.171
0.109
0.169


223448_x_at
0.373
0.247
0.183
0.193
0.214
0.416
0.184
0.209
0.214
0.349


223470_at
0.0942
0.182
0.18
0.145
0.0853
0.0911
0.169
0.327
0.181
0.225


223518_at
0.0823
0.0816
0.0938
0.105
0.115
0.14
0.0934
0.11
0.0844
0.112


223528_s_at
0.109
0.109
0.197
0.251
0.157
0.296
0.159
0.233
0.176
0.239


223570_at
0.0526
0.0329
0.0518
0.0457
0.134
0.0976
0.0947
0.109
0.0722
0.122


224473_x_at
0.1
0.1
0.133
0.107
0.159
0.202
0.0769
0.128
0.16
0.132


224721_at
0.135
0.0996
0.151
0.151
0.0962
0.322
0.122
0.19
0.156
0.228


225025_at
0.0942
0.0916
0.114
0.0936
0.0796
0.15
0.0769
0.0777
0.127
0.0738


225097_at
0.0509
0.101
0.111
0.0502
0.0825
0.0813
0.325
0.366
0.0742
0.209


225506_at
0.193
0.0966
0.153
0.118
0.132
0.12
0.13
0.0986
0.215
0.118


225554_s_at
0.246
0.272
0.43
0.297
0.407
0.475
0.254
0.263
0.419
0.436


225584_at
0.0517
0.0548
0.0617
0.0671
0.0613
0.0456
0.0536
0.0383
0.0539
0.0634


225841_at
0.266
0.2
0.563
0.245
0.325
0.244
0.133
0.209
0.103
0.295


225947_at
0.516
0.434
0.434
0.453
0.563
0.394
0.389
0.256
0.371
0.517


226124_at
0.138
0.132
0.202
0.129
0.0739
0.124
0.115
0.157
0.13
0.205


226139_at
0.0577
0.0692
0.0592
0.0632
0.0567
0.0651
0.0577
0.0847
0.0824
0.0634


226308_at
0.0509
0.0229
0.0222
0.01
0.0928
0.0423
0.0604
0.0348
0.0478
0.0918


226428_at
0.154
0.107
0.123
0.0575
0.245
0.133
0.132
0.169
0.176
0.276


226616_s_at
0.479
0.389
0.432
0.608
0.419
0.452
0.312
0.202
0.369
0.397


226651_at
0.0679
0.0324
0.0247
0.122
0.0309
0.0911
0.144
0.173
0.151
0.127


226693_at
0.115
0.0901
0.131
0.142
0.121
0.0813
0.0879
0.216
0.127
0.158


226749_at
0.173
0.193
0.432
0.251
0.204
0.29
0.162
0.194
0.377
0.29


226810_at
0.117
0.148
0.0913
0.0688
1.081
0.0618
1.545
0.634
0.934
1.86


226839_at
0.129
0.144
0.104
0.0665
0.171
0.133
0.147
0.152
0.149
0.144


226917_s_at
0.288
0.367
0.333
0.385
0.197
0.673
0.441
0.375
0.419
0.306


227181_at
0.0509
0.0488
0.0617
0.0632
0.0573
0.0878
0.135
0.087
0.15
0.195


227412_at
0.078
0.0582
0.0889
0.0293
0.0704
0.0521
0.0426
0.0928
0.0956
0.123


227427_at
0.0365
0.0219
0.0296
0.0242
0.0366
0.0748
0.0302
0.029
0.131
0.0322


227472_at
0.0322
0.0363
0.0518
0.0344
0.0292
0.0423
0.01
0.0244
0.0376
0.0322


227603_at
0.084
0.365
0.16
0.0885
0.145
0.277
0.305
0.194
0.167
0.426


227810_at
0.148
0.22
0.141
0.151
0.175
0.0878
0.15
0.0859
0.135
0.212


227921_at
0.268
0.308
0.118
0.066
0.238
0.208
0.288
0.393
0.672
0.541


228286_at
0.0509
0.0587
0.0592
0.0541
0.059
0.0553
0.0687
0.0569
0.0793
0.0871


228650_at
0.102
0.134
0.146
0.104
0.114
0.221
0.0961
0.178
0.19
0.168


228736_at
0.0458
0.0488
0.01
0.0265
0.01
0.0228
0.0275
0.0232
0.0264
0.01


228930_at
0.0993
0.191
0.079
0.216
0.142
0.153
0.113
0.124
0.117
0.11


229001_at
0.0763
0.0483
0.0518
0.01
0.0567
0.0488
0.0426
0.175
0.0885
0.19


229035_s_at
0.111
0.172
0.126
0.121
0.0773
0.114
0.146
0.121
0.162
0.135


229384_at
0.101
0.115
0.0839
0.0806
0.0744
0.0846
0.173
0.0708
0.114
0.151


229421_s_at
0.01
0.01
0.042
0.01
0.01
0.0228
0.0261
0.01
0.01
0.01


229534_at
0.0789
0.0244
0.136
0.0722
0.0344
0.0553
0.0247
0.0209
0.0437
0.0303


229570_at
0.039
0.0448
0.0543
0.0288
0.0304
0.01
0.0288
0.0534
0.0874
0.0303


230048_at
0.01
0.01
0.01
0.01
0.0223
0.0228
0.0302
0.01
0.01
0.01


230791_at
0.118
0.144
0.01
0.0316
0.404
0.0456
2.72
1.519
0.215
0.775


230922_x_at
0.0314
0.0388
0.037
0.0276
0.0412
0.039
0.0522
0.0336
0.0417
0.0454


230983_at
0.0288
0.0314
0.0272
0.0276
0.0229
0.0325
0.0302
0.0313
0.01
0.0275


231271_x_at
0.197
0.196
0.22
0.203
0.287
0.238
0.255
0.328
0.24
0.287


232524_x_at
0.221
0.316
0.353
0.289
0.162
0.446
0.283
0.308
0.341
0.173


232527_at
0.01
0.0672
0.0666
0.0592
0.0647
0.0586
0.114
0.0812
0.0996
0.0748


233214_at
0.146
0.194
0.114
0.109
0.114
0.107
0.119
0.153
0.165
0.0559


233302_at
0.0246
0.0677
0.0222
0.0209
0.083
0.0358
0.01
0.123
0.01
0.0511


233429_at
0.01
0.0334
0.0321
0.0383
0.0309
0.0325
0.0247
0.0278
0.0386
0.0303


233440_at
0.0373
0.0418
0.0296
0.0361
0.0613
0.0488
0.0522
0.0685
0.0458
0.0322


233493_at
0.0212
0.0264
0.0247
0.01
0.01
0.01
0.0233
0.0267
0.0244
0.01


233599_at
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01


234735_s_at
0.114
0.104
0.188
0.0795
0.145
0.111
0.092
0.171
0.198
0.114


235363_at
0.0619
0.0682
0.0247
0.044
0.138
0.0846
0.194
0.0777
0.13
0.206


235467_s_at
0.01
0.0279
0.042
0.0265
0.0767
0.0325
0.0453
0.029
0.0407
0.0426


235634_at
0.0339
0.0353
0.0444
0.0412
0.0401
0.0748
0.0343
0.0453
0.0386
0.0322


236312_at
0.0696
0.0568
0.01
0.0231
0.0452
0.0325
0.0934
0.029
0.0712
0.0303


236875_at
0.01
0.01
0.0222
0.01
0.0212
0.0228
0.022
0.01
0.0224
0.01


237023_at
0.0322
0.0548
0.0395
0.0502
0.0401
0.0488
0.0481
0.0441
0.0702
0.0398


239496_at
0.01
0.0358
0.0222
0.0564
0.0355
0.0456
0.081
0.0801
0.0681
0.127


240130_at
0.01
0.01
0.0346
0.0231
0.0206
0.0293
0.022
0.0209
0.0224
0.01


241395_at
0.0424
0.0468
0.0346
0.0355
0.0281
0.0553
0.0549
0.0302
0.0376
0.0483


242171_at
0.0254
0.01
0.01
0.01
0.0435
0.0358
0.081
0.0383
0.0427
0.0549


242602_x_at
0.0543
0.0617
0.0592
0.0519
0.0687
0.0618
0.0728
0.0313
0.0824
0.0682


242606_at
0.0509
0.0363
0.037
0.0333
0.01
0.026
0.01
0.022
0.01
0.01


243003_at
0.0611
0.113
0.0617
0.156
0.131
0.12
0.141
0.168
0.108
0.224


243185_at
0.0229
0.0428
0.01
0.0242
0.01
0.039
0.01
0.01
0.01
0.01


31826_at
0.0715
0.0701
0.115
0.0634
0.0767
0.0625
0.146
0.0866
0.0795
0.0895


35150_at
0.0388
0.0461
0.0653
0.0601
0.0898
0.0527
0.0458
0.0261
0.0303
0.0398


64474_g_at
0.0816
0.0602
0.0274
0.0317
0.058
0.0332
0.0299
0.0795
0.0239
0.046


91617_at
0.0436
0.0387
0.01
0.0388
0.0471
0.0898
0.0472
0.0433
0.0422
0.0576





















MAXF_MX1, Avastin_p
RXF_1393, Avastin_p
CXF_1044,
CXF_1753,
CXF_1784,
CXF_280,
CXF_609,
CXF_676,
CXF_94LX,




NC
NC
Avastin_p P
Avastin_p P
Avastin_p P
Avastin_p P
Avastin_p P
Avastin_p P
Avastin_p P
LXFA_1012, Avastin_p P


Systematic Name
normalized
normalized
normalized
normalized
normalized
normalized
normalized
normalized
normalized
normalized





200076_s_at
0.179
0.212
0.0712
0.132
0.104
0.177
0.153
0.0847
0.142
0.102


200631_s_at
0.664
0.227
0.573
0.753
0.571
0.954
0.495
0.611
0.727
0.653


201722_s_at
0.0975
0.076
0.18
0.216
0.147
0.15
0.349
0.169
0.16
0.301


201919_at
0.222
0.404
0.25
0.303
0.214
0.213
0.203
0.234
0.261
0.213


202333_s_at
0.0499
0.105
0.319
0.138
0.293
0.0834
0.126
0.371
0.0787
0.333


202758_s_at
0.0983
0.0962
0.0582
0.0463
0.0672
0.055
0.0406
0.0635
0.0416
0.0428


203092_at
0.0735
0.0414
0.0462
0.0385
0.0318
0.0461
0.0215
0.01
0.0362
0.0358


203846_at
0.044
0.0523
0.0442
0.0687
0.0448
0.0688
0.0315
0.0375
0.0597
0.0508


205042_at
0.01
0.0743
0.248
0.322
0.124
0.098
0.0832
0.327
0.01
0.117


205046_at
0.0822
0.054
0.01
0.0336
0.0385
0.0357
0.01
0.0317
0.0647
0.0497


205105_at
0.0279
0.0785
0.0874
0.0981
0.0594
0.0469
0.0695
0.18
0.0801
0.0598


205481_at
0.01
0.0397
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01


206003_at
0.01
0.0422
0.01
0.01
0.0346
0.0254
0.01
0.0318
0.024
0.139


208369_s_at
0.0574
0.0641
0.0238
0.0336
0.0291
0.01
0.0272
0.01
0.0258
0.01


208848_at
0.0425
0.113
0.0398
0.0764
0.165
0.0277
0.0413
0.0586
0.0547
0.0554


208951_at
0.116
0.105
0.0391
0.0708
0.0508
0.035
0.0289
0.0672
0.052
0.14


209161_at
0.081
0.043
0.0754
0.0939
0.138
0.137
0.0591
0.0698
0.0968
0.128


209758_s_at
0.01
0.0338
0.0258
0.0231
0.01
0.01
0.01
0.01
0.01
0.0265


211974_x_at
0.131
0.44
0.0987
0.407
0.149
0.14
0.171
0.179
0.204
0.114


211976_at
0.0967
0.12
0.0933
0.144
0.132
0.129
0.106
0.155
0.199
0.177


212394_at
0.01
0.0287
0.01
0.0224
0.01
0.01
0.01
0.0202
0.01
0.01


213677_s_at
0.0936
0.17
0.113
0.0967
0.171
0.0596
0.0382
0.0698
0.108
0.0926


214086_s_at
0.0688
0.0903
0.0466
0.101
0.0671
0.0496
0.0346
0.0374
0.0611
0.172


214585_s_at
0.092
0.231
0.143
0.245
0.181
0.0969
0.123
0.221
0.117
0.177


214672_at
0.0786
0.0911
0.0483
0.0729
0.0532
0.0415
0.0661
0.0587
0.062
0.0453


214844_s_at
0.202
0.149
0.01
0.01
0.01
0.01
0.01
0.01
0.0262
0.022


217797_at
0.38
0.341
0.279
0.237
0.42
0.477
0.328
0.457
0.371
0.594


217895_at
0.0877
0.104
0.152
0.197
0.191
0.12
0.053
0.112
0.131
0.111


218625_at
0.121
0.0945
0.01
0.0904
0.01
0.01
0.01
0.01
0.01
0.01


218768_at
0.169
0.349
0.18
0.297
0.214
0.249
0.138
0.181
0.201
0.187


218818_at
0.0204
0.01
0.0218
0.01
0.0207
0.01
0.01
0.021
0.01
0.01


218998_at
0.0464
0.129
0.0973
0.0974
0.13
0.12
0.0936
0.0976
0.0737
0.115


219595_at
0.0248
0.13
0.0417
0.0624
0.0387
0.0361
0.0292
0.0381
0.0299
0.0412


219906_at
0.0358
0.0295
0.01
0.0582
0.01
0.01
0.0453
0.01
0.0357
0.01


221214_s_at
0.0311
0.0321
0.0626
0.0715
0.0524
0.131
0.0336
0.0774
0.0321
0.0659


221249_s_at
0.0311
0.0397
0.0573
0.0876
0.0463
0.03
0.0208
0.0464
0.0204
0.052


222587_s_at
0.0269
0.0587
0.107
0.1
0.125
0.038
0.0679
0.171
0.0964
0.116


222612_at
0.0665
0.0543
0.0248
0.0626
0.0284
0.01
0.041
0.0314
0.0716
0.0343


222775_s_at
0.146
0.0925
0.0692
0.185
0.0603
0.116
0.103
0.0604
0.164
0.0764


222807_at
0.0616
0.0822
0.0245
0.0496
0.0358
0.01
0.0314
0.033
0.0482
0.0396


222906_at
0.178
0.129
0.0505
0.117
0.0891
0.1
0.0865
0.0572
0.343
0.0547


223175_s_at
0.0856
0.0866
0.05
0.0637
0.0469
0.0814
0.0474
0.0446
0.0533
0.0682


223197_s_at
0.188
0.22
0.0553
0.11
0.0878
0.103
0.115
0.0591
0.163
0.0748


223206_s_at
0.168
0.156
0.0562
0.0921
0.103
0.109
0.122
0.108
0.128
0.0757


223448_x_at
0.447
0.185
0.0814
0.197
0.0749
0.308
0.176
0.0615
0.33
0.0915


223470_at
0.206
0.113
0.0653
0.0992
0.0876
0.0993
0.0474
0.128
0.143
0.108


223518_at
0.0998
0.113
0.0372
0.113
0.0284
0.0803
0.0455
0.0278
0.0628
0.0247


223528_s_at
0.29
0.358
0.0481
0.22
0.0266
0.133
0.22
0.0454
0.0621
0.0745


223570_at
0.0722
0.0778
0.01
0.0212
0.0375
0.0814
0.01
0.01
0.0285
0.0613


224473_x_at
0.126
0.11
0.037
0.0519
0.0587
0.0888
0.082
0.042
0.0694
0.0434


224721_at
0.0835
0.181
0.104
0.13
0.144
0.0676
0.0769
0.0837
0.121
0.103


225025_at
0.199
0.0939
0.0289
0.0437
0.0268
0.0655
0.0948
0.0461
0.0606
0.0512


225097_at
0.075
0.506
0.0851
0.15
0.01
0.01
0.0512
0.01
0.17
0.0776


225506_at
0.201
0.114
0.0457
0.146
0.0392
0.146
0.0673
0.0426
0.117
0.0228


225554_s_at
0.289
0.339
0.112
0.313
0.109
0.448
0.209
0.0623
0.239
0.164


225584_at
0.041
0.0572
0.0471
0.0531
0.0577
0.0201
0.0461
0.044
0.046
0.034


225841_at
0.417
0.0382
0.0787
0.0744
0.13
0.0951
0.111
0.0803
0.127
0.0226


225947_at
0.346
0.339
0.0669
0.351
0.108
0.348
0.214
0.0714
0.379
0.151


226124_at
0.206
0.208
0.0385
0.117
0.0358
0.0613
0.0929
0.0274
0.113
0.0497


226139_at
0.0792
0.0294
0.01
0.0425
0.01
0.0497
0.0493
0.01
0.0248
0.0249


226308_at
0.0396
0.0205
0.01
0.0201
0.01
0.0317
0.01
0.01
0.01
0.0206


226428_at
0.228
0.116
0.0543
0.102
0.0392
0.185
0.0813
0.0436
0.0921
0.0272


226616_s_at
0.304
0.324
0.164
0.269
0.0942
0.224
0.154
0.114
0.346
0.192


226651_at
0.075
0.112
0.0223
0.0685
0.0618
0.0581
0.01
0.0204
0.0818
0.03


226693_at
0.16
0.364
0.0476
0.111
0.0384
0.0793
0.0788
0.0837
0.11
0.0752


226749_at
0.195
0.17
0.0976
0.263
0.137
0.17
0.0941
0.0783
0.181
0.0885


226810_at
0.606
0.451
0.0218
0.0531
0.0407
0.038
0.025
0.01
0.01
0.143


226839_at
0.201
0.131
0.0535
0.0602
0.0555
0.114
0.0781
0.054
0.095
0.0543


226917_s_at
0.217
0.49
0.0674
0.349
0.123
0.144
0.123
0.101
0.373
0.138


227181_at
0.0545
0.355
0.01
0.059
0.01
0.0877
0.0423
0.01
0.107
0.0281


227412_at
0.0934
0.0881
0.0231
0.0602
0.01
0.0465
0.111
0.022
0.104
0.021


227427_at
0.0764
0.0763
0.01
0.01
0.01
0.0275
0.01
0.01
0.01
0.01


227472_at
0.0333
0.0338
0.01
0.0295
0.01
0.0222
0.01
0.01
0.0227
0.01


227603_at
0.155
0.216
0.0252
0.117
0.0282
0.111
0.0897
0.0486
0.0782
0.0436


227810_at
0.103
0.0528
0.0732
0.166
0.0777
0.074
0.113
0.0838
0.17
0.143


227921_at
0.299
0.414
0.0267
0.184
0.188
0.159
0.103
0.0515
0.207
0.111


228286_at
0.0842
0.0998
0.0385
0.0767
0.0617
0.0232
0.0224
0.0392
0.138
0.0577


228650_at
0.0651
0.134
0.0824
0.0767
0.05
0.074
0.0269
0.0401
0.18
0.0793


228736_at
0.0297
0.0543
0.01
0.0224
0.01
0.01
0.0282
0.01
0.0263
0.0216


228930_at
0.117
0.122
0.0303
0.0779
0.0298
0.0655
0.0865
0.0212
0.129
0.069


229001_at
0.111
0.0954
0.01
0.0755
0.01
0.01
0.113
0.0359
0.057
0.01


229035_s_at
0.0807
0.135
0.01
0.116
0.037
0.0919
0.073
0.0335
0.172
0.0539


229384_at
0.087
0.156
0.0219
0.116
0.0293
0.0676
0.101
0.0409
0.11
0.0229


229421_s_at
0.01
0.01
0.01
0.0331
0.01
0.0285
0.01
0.01
0.0212
0.01


229534_at
0.0736
0.0455
0.026
0.0295
0.0222
0.0338
0.01
0.01
0.0278
0.0396


229570_at
0.0439
0.0426
0.01
0.01
0.01
0.0243
0.01
0.01
0.0431
0.01


230048_at
0.01
0.01
0.0212
0.0236
0.01
0.0275
0.0423
0.0322
0.0263
0.0211


230791_at
0.313
0.294
0.01
0.0862
0.0245
0.0486
0.124
0.0428
0.0716
0.0743


230922_x_at
0.01
0.0866
0.0208
0.0519
0.034
0.0476
0.01
0.0241
0.0351
0.0309


230983_at
0.0219
0.0249
0.01
0.01
0.01
0.0444
0.01
0.01
0.0409
0.01


231271_x_at
0.158
0.415
0.0486
0.264
0.0925
0.0856
0.125
0.0874
0.184
0.0659


232524_x_at
0.232
0.217
0.059
0.184
0.12
0.0909
0.101
0.0974
0.226
0.126


232527_at
0.142
0.0895
0.0253
0.0685
0.01
0.0317
0.0762
0.0224
0.111
0.0239


233214_at
0.0877
0.123
0.0493
0.0992
0.0597
0.0623
0.0813
0.0338
0.0921
0.0429


233302_at
0.0899
0.0352
0.01
0.0909
0.01
0.0402
0.01
0.0208
0.103
0.01


233429_at
0.0241
0.069
0.01
0.0271
0.01
0.01
0.0205
0.01
0.0256
0.01


233440_at
0.01
0.0661
0.01
0.0543
0.01
0.0243
0.01
0.01
0.01
0.0238


233493_at
0.01
0.0396
0.01
0.01
0.01
0.01
0.0211
0.01
0.01
0.01


233599_at
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01


234735_s_at
0.171
0.0939
0.01
0.01
0.037
0.0782
0.089
0.0486
0.0979
0.0394


235363_at
0.0828
0.0675
0.0249
0.0449
0.0374
0.056
0.01
0.0311
0.076
0.0349


235467_s_at
0.0538
0.0294
0.01
0.0224
0.01
0.0243
0.01
0.01
0.01
0.01


235634_at
0.0311
0.091
0.01
0.0248
0.01
0.0232
0.0256
0.01
0.0256
0.01


236312_at
0.0453
0.0382
0.0202
0.0449
0.0428
0.01
0.0288
0.0366
0.0913
0.01


236875_at
0.0233
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01


237023_at
0.0403
0.0499
0.0242
0.0389
0.0233
0.038
0.0333
0.01
0.0365
0.01


239496_at
0.0318
0.0499
0.01
0.0283
0.01
0.0285
0.01
0.01
0.0212
0.01


240130_at
0.01
0.0235
0.01
0.01
0.01
0.0275
0.01
0.01
0.01
0.01


241395_at
0.0283
0.01
0.01
0.0283
0.01
0.01
0.0365
0.01
0.0818
0.01


242171_at
0.0389
0.0338
0.01
0.0212
0.01
0.01
0.0224
0.01
0.01
0.01


242602_x_at
0.0736
0.0793
0.0312
0.0496
0.0344
0.0528
0.05
0.0344
0.038
0.0231


242606_at
0.01
0.01
0.01
0.0331
0.01
0.0232
0.01
0.01
0.0658
0.01


243003_at
0.0927
0.144
0.01
0.0968
0.024
0.0539
0.0224
0.01
0.0891
0.0286


243185_at
0.01
0.0352
0.01
0.0354
0.01
0.01
0.0218
0.01
0.01
0.01


31826_at
0.0566
0.106
0.0658
0.0757
0.0545
0.0892
0.0651
0.0817
0.071
0.0535


35150_at
0.0204
0.107
0.045
0.0519
0.0379
0.0503
0.0648
0.0526
0.0416
0.0305


64474_g_at
0.0594
0.0414
0.0618
0.0449
0.0423
0.0427
0.0245
0.0269
0.0393
0.0399


91617_at
0.0448
0.065
0.0399
0.0357
0.0306
0.0354
0.0201
0.0274
0.0561
0.0511






















LXFA_526,

LXFA_629,
LXFA_644,
LXFA_737,
LXFA_PC14,
LXFE_211,

MAXF_1162,



LXFA_289, Avastin_p
Avastin_p
LXFA_586, Avastin_p
Avastin_p
Avastin_p
Avastin_p
Avastin_p
Avastin_p
LXFL_529, Avastin_p
Avastin_p


Systematic Name
P normalized
P normalized
P normalized
P normalized
P normalized
P normalized
P normalized
P normalized
P normalized
P normalized





200076_s_at
0.219
0.294
0.149
0.142
0.0549
0.0548
0.137
0.125
0.15
0.0923


200631_s_at
0.637
0.791
0.42
0.456
0.414
0.62
0.843
1.317
0.56
0.626


201722_s_at
0.161
0.102
0.153
0.152
0.48
0.171
0.233
0.146
0.114
0.134


201919_at
0.189
0.152
0.19
0.204
0.114
0.243
0.187
0.143
0.222
0.254


202333_s_at
0.197
0.11
0.2
0.0559
0.297
0.135
0.314
0.135
0.131
0.0825


202758_s_at
0.0568
0.0607
0.01
0.01
0.0653
0.01
0.11
0.0696
0.0401
0.01


203092_at
0.0277
0.0228
0.01
0.01
0.0228
0.01
0.043
0.04
0.0419
0.0228


203846_at
0.0502
0.0654
0.0639
0.0928
0.0594
0.0523
0.103
0.145
0.0577
0.0393


205042_at
0.296
0.12
0.0433
0.105
0.0992
0.322
0.0489
0.0253
0.123
0.0487


205046_at
0.04
0.0501
0.0274
0.0223
0.061
0.0522
0.0492
0.0662
0.0387
0.0361


205105_at
0.135
0.0392
0.0422
0.0304
0.059
0.0532
0.0622
0.151
0.0525
0.022


205481_at
0.0226
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.0273
0.022


206003_at
0.01
0.0317
0.0239
0.0284
0.0364
0.0722
0.0225
0.01
0.01
0.01


208369_s_at
0.024
0.0296
0.01
0.01
0.0274
0.0227
0.0313
0.0339
0.01
0.0236


208848_at
0.0408
0.0971
0.0901
0.0365
0.0391
0.0495
0.0612
0.208
0.0648
0.0692


208951_at
0.0473
0.0324
0.121
0.0397
0.127
0.0612
0.0688
0.0818
0.0533
0.0479


209161_at
0.116
0.203
0.103
0.113
0.0867
0.0939
0.161
0.25
0.119
0.0786


209758_s_at
0.099
0.401
0.244
0.0276
0.0283
0.0247
0.239
0.01
0.01
0.0919


211974_x_at
0.23
0.208
0.177
0.163
0.14
0.139
0.141
0.212
0.294
0.277


211976_at
0.197
0.0821
0.0479
0.062
0.0609
0.0868
0.0858
0.123
0.101
0.101


212394_at
0.01
0.0327
0.01
0.01
0.0209
0.01
0.0312
0.01
0.0273
0.01


213677_s_at
0.0648
0.0883
0.0821
0.077
0.169
0.117
0.0648
0.0421
0.0818
0.0589


214086_s_at
0.0546
0.0382
0.0525
0.0491
0.0638
0.09
0.0453
0.0754
0.046
0.033


214585_s_at
0.182
0.148
0.132
0.206
0.208
0.18
0.165
0.172
0.117
0.166


214672_at
0.0495
0.0429
0.0331
0.0572
0.0511
0.0534
0.0663
0.108
0.0448
0.0542


214844_s_at
0.01
0.01
0.01
0.01
0.01
0.0301
0.01
0.01
0.0217
0.0228


217797_at
0.791
0.214
0.375
0.225
0.915
0.429
0.282
0.331
0.299
0.31


217895_at
0.0801
0.0692
0.0525
0.102
0.0645
0.0829
0.104
0.117
0.118
0.105


218625_at
0.01
0.01
0.0433
0.01
0.01
0.01
0.01
0.237
0.01
0.01


218768_at
0.245
0.18
0.173
0.238
0.175
0.165
0.214
0.222
0.213
0.123


218818_at
0.01
0.01
0.0228
0.0247
0.0238
0.0291
0.0325
0.0311
0.01
0.0251


218998_at
0.124
0.128
0.115
0.11
0.0416
0.0487
0.124
0.0983
0.0894
0.0432


219595_at
0.0408
0.0314
0.0388
0.0357
0.02
0.0457
0.0634
0.0522
0.0407
0.0369


219906_at
0.0335
0.01
0.0308
0.0247
0.01
0.01
0.01
0.0363
0.046
0.0283


221214_s_at
0.0524
0.0702
0.01
0.0361
0.0287
0.0562
0.118
0.0644
0.022
0.0566


221249_s_at
0.0255
0.0286
0.0365
0.01
0.0217
0.0435
0.021
0.0577
0.0542
0.01


222587_s_at
0.152
0.116
0.0658
0.132
0.132
0.069
0.103
0.0412
0.0398
0.0373


222612_at
0.0506
0.0359
0.0279
0.0476
0.0312
0.0317
0.0246
0.0443
0.0628
0.0607


222775_s_at
0.106
0.0837
0.0918
0.0717
0.0513
0.0773
0.0399
0.0734
0.0852
0.0835


222807_at
0.0594
0.0341
0.0499
0.0456
0.0286
0.0337
0.0419
0.0398
0.0359
0.0451


222906_at
1.034
0.0527
0.271
0.0938
0.114
0.0301
0.0346
0.127
0.225
0.139


223175_s_at
0.091
0.0607
0.0479
0.0664
0.0407
0.0547
0.0359
0.0519
0.0449
0.102


223197_s_at
0.125
0.169
0.154
0.126
0.0618
0.0621
0.056
0.148
0.149
0.117


223206_s_at
0.143
0.109
0.01
0.133
0.0472
0.0894
0.117
0.144
0.1
0.148


223448_x_at
0.091
0.144
0.13
0.158
0.0614
0.0561
0.0906
0.159
0.169
0.216


223470_at
0.107
0.0611
0.0938
0.0871
0.139
0.111
0.0616
0.373
0.0516
0.118


223518_at
0.0695
0.109
0.0698
0.0757
0.0433
0.0357
0.0206
0.0774
0.11
0.0487


223528_s_at
0.0809
0.0616
0.0639
0.149
0.0544
0.121
0.0476
0.0465
0.104
0.154


223570_at
0.0544
0.0235
0.0359
0.0369
0.01
0.0459
0.0368
0.0528
0.0348
0.0607


224473_x_at
0.0948
0.0372
0.0958
0.0905
0.043
0.0598
0.0444
0.0769
0.11
0.154


224721_at
0.14
0.147
0.0738
0.145
0.0724
0.101
0.045
0.0479
0.0937
0.0613


225025_at
0.147
0.0616
0.13
0.114
0.0227
0.0538
0.0412
0.119
0.0684
0.103


225097_at
0.0278
0.0492
0.0279
0.053
0.0663
0.0537
0.0338
0.505
0.0432
0.118


225506_at
0.115
0.0829
0.0798
0.0858
0.078
0.0486
0.0271
0.0783
0.078
0.113


225554_s_at
0.311
0.193
0.164
0.417
0.107
0.165
0.0862
0.301
0.14
0.32


225584_at
0.0518
0.102
0.0539
0.0349
0.0386
0.0489
0.0643
0.0599
0.0667
0.0361


225841_at
0.166
0.114
0.158
0.205
0.139
0.128
0.0755
0.189
0.153
0.159


225947_at
0.513
0.535
0.467
0.469
0.119
0.101
0.103
0.167
0.237
0.238


226124_at
0.105
0.0665
0.0738
0.065
0.0574
0.0338
0.0335
0.127
0.142
0.104


226139_at
0.163
0.0275
0.0698
0.059
0.0285
0.0215
0.01
0.0438
0.0426
0.0715


226308_at
0.0266
0.0235
0.01
0.01
0.01
0.01
0.0226
0.0389
0.01
0.0258


226428_at
0.119
0.157
0.0718
0.0818
0.0471
0.0505
0.038
0.0769
0.0555
0.0811


226616_s_at
0.269
0.343
0.637
0.0938
0.137
0.188
0.0991
0.489
0.313
0.298


226651_at
0.0594
0.0425
0.0658
0.107
0.0718
0.0297
0.0392
0.181
0.165
0.3


226693_at
0.143
0.0341
0.0838
0.0938
0.0636
0.0494
0.045
0.0792
0.0802
0.0805


226749_at
0.161
0.149
0.152
0.153
0.0633
0.15
0.0607
0.201
0.174
0.147


226810_at
0.0455
0.167
0.0439
0.0241
0.0221
0.0688
0.112
0.0573
0.0538
0.157


226839_at
0.148
0.126
0.0639
0.0617
0.0275
0.0564
0.0584
0.0935
0.0634
0.0974


226917_s_at
0.269
0.149
0.251
0.202
0.126
0.135
0.126
0.161
0.234
0.231


227181_at
0.0468
0.051
0.0339
0.0543
0.0283
0.028
0.0211
0.148
0.156
0.132


227412_at
0.01
0.0275
0.02
0.0302
0.01
0.01
0.01
0.0255
0.0303
0.0445


227427_at
0.0228
0.01
0.0319
0.0308
0.01
0.01
0.01
0.01
0.0252
0.0715


227472_at
0.0291
0.0266
0.01
0.0201
0.01
0.01
0.01
0.01
0.01
0.01


227603_at
0.142
0.0301
0.104
0.225
0.01
0.11
0.049
0.123
0.123
0.354


227810_at
0.109
0.0244
0.0798
0.0851
0.0748
0.0647
0.0975
0.0769
0.14
0.0727


227921_at
0.139
0.134
0.257
0.114
0.0305
0.163
0.0244
0.211
0.0308
0.189


228286_at
0.0695
0.0478
0.0479
0.0677
0.0451
0.0417
0.0314
0.0501
0.0297
0.0505


228650_at
0.0923
0.0554
0.156
0.0308
0.0549
0.0485
0.0644
0.177
0.172
0.0631


228736_at
0.01
0.0213
0.01
0.01
0.01
0.01
0.01
0.0206
0.023
0.01


228930_at
0.086
0.093
0.0599
0.0818
0.0235
0.0409
0.0359
0.0778
0.136
0.0986


229001_at
0.0303
0.0399
0.01
0.0282
0.01
0.01
0.01
0.0304
0.01
0.0385


229035_s_at
0.107
0.0961
0.0479
0.103
0.01
0.0727
0.0292
0.0573
0.129
0.0823


229384_at
0.163
0.0744
0.0539
0.065
0.01
0.0224
0.0286
0.0617
0.0852
0.0571


229421_s_at
0.0341
0.01
0.0519
0.01
0.01
0.01
0.01
0.01
0.01
0.01


229534_at
0.0936
0.0319
0.0798
0.109
0.0252
0.193
0.0314
0.0273
0.01
0.0355


229570_at
0.0443
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.0224
0.0337


230048_at
0.01
0.218
0.01
0.01
0.01
0.01
0.0322
0.01
0.0505
0.01


230791_at
0.0632
0.0811
0.01
0.0489
0.0987
0.0331
0.01
0.0322
0.105
0.242


230922_x_at
0.0266
0.0687
0.0399
0.0221
0.0247
0.0295
0.0265
0.025
0.01
0.01


230983_at
0.0594
0.01
0.0339
0.0228
0.01
0.01
0.01
0.0268
0.0325
0.021


231271_x_at
0.234
0.212
0.01
0.134
0.0714
0.109
0.0798
0.244
0.164
0.239


232524_x_at
0.13
0.0771
0.263
0.174
0.11
0.14
0.115
0.128
0.138
0.226


232527_at
0.0455
0.0669
0.0339
0.0429
0.0236
0.0507
0.01
0.089
0.0937
0.0487


233214_at
0.191
0.0846
0.11
0.0858
0.0318
0.0911
0.0204
0.0756
0.0651
0.0673


233302_at
0.0202
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01


233429_at
0.0303
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.0337


233440_at
0.0556
0.01
0.0259
0.0308
0.01
0.01
0.01
0.01
0.0247
0.01


233493_at
0.01
0.0253
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01


233599_at
0.01
0.01
0.01
0.0248
0.01
0.01
0.01
0.0716
0.01
0.01


234735_s_at
0.11
0.0408
0.0559
0.0697
0.0652
0.036
0.0348
0.0742
0.0566
0.163


235363_at
0.01
0.0594
0.0599
0.0268
0.0386
0.01
0.0451
0.0819
0.01
0.0282


235467_s_at
0.01
0.0332
0.0279
0.0288
0.01
0.01
0.01
0.0268
0.01
0.01


235634_at
0.0544
0.0275
0.0259
0.0248
0.01
0.0209
0.01
0.0389
0.0561
0.0294


236312_at
0.01
0.01
0.0219
0.01
0.01
0.0228
0.01
0.0859
0.0365
0.01


236875_at
0.0354
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01


237023_at
0.01
0.0292
0.0299
0.0402
0.01
0.0233
0.01
0.0268
0.01
0.0331


239496_at
0.01
0.01
0.02
0.01
0.01
0.0209
0.01
0.0206
0.0247
0.0481


240130_at
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.0201
0.01
0.01


241395_at
0.0367
0.0337
0.0319
0.01
0.01
0.01
0.01
0.01
0.0286
0.0258


242171_at
0.024
0.0222
0.01
0.0201
0.01
0.0207
0.01
0.0291
0.01
0.0288


242602_x_at
0.0316
0.0372
0.0539
0.065
0.0272
0.0292
0.0289
0.0376
0.0381
0.0469


242606_at
0.01
0.0368
0.01
0.01
0.01
0.01
0.01
0.0201
0.0337
0.0228


243003_at
0.0885
0.01
0.0639
0.0637
0.01
0.0302
0.01
0.105
0.188
0.1


243185_at
0.0518
0.01
0.01
0.0268
0.01
0.01
0.01
0.01
0.01
0.01


31826_at
0.121
0.14
0.108
0.106
0.0565
0.0693
0.123
0.107
0.0993
0.0833


35150_at
0.0844
0.0385
0.0433
0.0397
0.0532
0.0467
0.0746
0.0561
0.0782
0.0644


64474_g_at
0.0429
0.0494
0.0285
0.0353
0.0492
0.0789
0.0593
0.0256
0.0475
0.01


91617_at
0.0604
0.0211
0.01
0.0377
0.0472
0.0771
0.0352
0.0333
0.034
0.0464






















MAXF_MCF7,

RXF_631,
RXF_944LX,
CXF_1103,
CXF_158,

LXFA_592,
LXFA_677,


Systematic
MAXF_449, Avastin_p
Avastin_p P
RXF_1220, Avastin_p
Avastin_p P
Avastin_p P
Avastin_p R
Avastin_p R
CXF_1729, Avastin_p
Avastin_p R
Avastin_p R


Name
P normalized
normalized
P normalized
normalized
normalized
normalized
normalized
R normalized
normalized
normalized





200076_s_at
0.199
0.142
0.211
0.223
0.18
0.175
0.152
0.146
0.151
0.128


200631_s_at
0.665
0.514
0.698
0.332
1.057
0.846
0.894
0.931
1.04
0.862


201722_s_at
0.133
0.0458
0.141
0.0912
0.0974
0.214
0.103
0.132
0.0719
0.0631


201919_at
0.281
0.176
0.239
0.322
0.461
0.283
0.333
0.305
0.448
0.296


202333_s_at
0.078
0.141
0.131
0.243
0.149
0.0606
0.0889
0.12
0.114
0.133


202758_s_at
0.066
0.053
0.0602
0.0586
0.0617
0.083
0.0718
0.0506
0.0602
0.0212


203092_at
0.0522
0.023
0.055
0.0259
0.0335
0.0925
0.0351
0.0577
0.0886
0.01


203846_at
0.01
0.0495
0.0499
0.01
0.0736
0.0585
0.0658
0.0806
0.0736
0.0763


205042_at
0.145
0.01
0.122
0.0867
0.0822
0.0372
0.0239
0.01
0.0318
0.0252


205046_at
0.0296
0.0288
0.0791
0.0417
0.079
0.067
0.0368
0.0798
0.0435
0.0482


205105_at
0.01
0.0547
0.0653
0.167
0.0487
0.13
0.0919
0.0965
0.0619
0.111


205481_at
0.0407
0.01
0.0997
0.0327
0.01
0.01
0.01
0.01
0.01
0.01


206003_at
0.01
0.0299
0.01
0.0259
0.01
0.0383
0.0274
0.0396
0.0251
0.0321


208369_s_at
0.0837
0.0368
0.0396
0.045
0.0303
0.0489
0.0423
0.0221
0.0619
0.0218


208848_at
0.0434
0.0308
0.129
0.0518
0.0963
0.0702
0.0616
0.0654
0.0652
0.0832


208951_at
0.105
0.122
0.0602
0.0946
0.0768
0.0745
0.0432
0.0424
0.01
0.0545


209161_at
0.0511
0.107
0.0946
0.0484
0.142
0.156
0.106
0.198
0.159
0.234


209758_s_at
0.0687
0.01
0.0224
0.588
0.0206
0.0223
0.01
0.01
0.01
0.01


211974_x_at
0.176
0.226
0.342
0.393
0.253
0.364
0.275
0.483
0.406
0.244


211976_at
0.123
0.0841
0.098
0.0777
0.119
0.117
0.194
0.198
0.268
0.132


212394_at
0.01
0.01
0.0396
0.01
0.0303
0.033
0.0325
0.01
0.0201
0.01


213677_s_at
0.1
0.0616
0.0946
0.08
0.0508
0.0968
0.103
0.139
0.151
0.131


214086_s_at
0.0253
0.0443
0.0516
0.0349
0.093
0.0723
0.0504
0.0438
0.0886
0.0809


214585_s_at
0.162
0.125
0.225
0.227
0.167
0.195
0.2
0.268
0.273
0.292


214672_at
0.0515
0.0875
0.0413
0.0428
0.12
0.0936
0.0667
0.0843
0.0686
0.106


214844_s_at
0.01
0.01
0.0344
0.0203
0.01
0.01
0.01
0.01
0.01
0.01


217797_at
0.405
0.317
0.487
0.467
0.195
0.282
0.24
0.175
0.139
0.169


217895_at
0.126
0.0504
0.115
0.0698
0.0595
0.177
0.162
0.162
0.166
0.11


218625_at
0.01
0.01
0.01
0.01
0.13
0.01
0.0218
0.258
0.0284
0.01


218768_at
0.197
0.214
0.244
0.17
0.115
0.307
0.276
0.237
0.301
0.18


218818_at
0.01
0.01
0.01
0.0664
0.01
0.0468
0.0222
0.0263
0.0284
0.0442


218998_at
0.0223
0.0478
0.105
0.0586
0.0963
0.146
0.151
0.164
0.174
0.147


219595_at
0.0388
0.0423
0.086
0.0518
0.0487
0.0734
0.0598
0.0436
0.0937
0.0539


219906_at
0.01
0.0363
0.01
0.01
0.0227
0.0426
0.0496
0.0407
0.01
0.0252


221214_s_at
0.0453
0.0581
0.0567
0.0462
0.0563
0.149
0.0667
0.0554
0.0652
0.039


221249_s_at
0.0534
0.0279
0.0327
0.0439
0.0249
0.0223
0.0568
0.0936
0.154
0.0258


222587_s_at
0.0337
0.0664
0.234
0.0296
0.0543
0.0572
0.0581
0.104
0.118
0.126


222612_at
0.0902
0.0658
0.0832
0.0355
0.0379
0.0286
0.0342
0.0591
0.0502
0.0222


222775_s_at
0.0791
0.0622
0.0928
0.069
0.0666
0.107
0.0932
0.1
0.133
0.108


222807_at
0.141
0.0514
0.0812
0.0709
0.0728
0.0338
0.0607
0.0353
0.0968
0.0611


222906_at
0.222
0.0329
0.0948
0.0591
0.043
0.0416
0.0983
0.277
0.219
0.0689


223175_s_at
0.0628
0.0526
0.104
0.0631
0.0646
0.101
0.0727
0.0669
0.0788
0.0678


223197_s_at
0.106
0.0454
0.149
0.134
0.137
0.0884
0.121
0.249
0.168
0.202


223206_s_at
0.208
0.239
0.18
0.175
0.161
0.101
0.112
0.0778
0.0968
0.136


223448_x_at
0.396
0.135
0.195
0.331
0.358
0.299
0.262
0.179
0.229
0.396


223470_at
0.144
0.0807
0.0716
0.0729
0.0605
0.0338
0.0804
0.135
0.0824
0.106


223518_at
0.1
0.0622
0.147
0.13
0.129
0.169
0.113
0.0756
0.129
0.09


223528_s_at
0.12
0.142
0.0928
0.152
0.2
0.408
0.152
0.115
0.125
0.101


223570_at
0.0646
0.0323
0.0561
0.0769
0.0441
0.0598
0.0513
0.0444
0.0394
0.0522


224473_x_at
0.105
0.16
0.238
0.0946
0.127
0.159
0.0966
0.0751
0.143
0.0934


224721_at
0.123
0.0604
0.139
0.142
0.139
0.153
0.0821
0.129
0.147
0.211


225025_at
0.224
0.0586
0.0928
0.0729
0.0902
0.0988
0.171
0.0678
0.0287
0.0667


225097_at
0.119
0.0323
0.503
0.13
0.083
0.203
0.1
0.119
0.964
0.17


225506_at
0.201
0.149
0.0754
0.0591
0.0738
0.164
0.158
0.0911
0.122
0.11


225554_s_at
0.242
0.163
0.354
0.179
0.179
0.419
0.307
0.335
0.441
0.269


225584_at
0.0628
0.0442
0.145
0.122
0.112
0.0832
0.0513
0.0952
0.0824
0.0789


225841_at
0.141
0.412
0.0484
0.0414
0.198
0.0338
0.109
0.138
0.0753
0.147


225947_at
0.201
0.184
0.391
0.3
0.307
0.471
0.404
0.435
0.731
0.292


226124_at
0.103
0.139
0.132
0.209
0.122
0.0754
0.0778
0.0856
0.0645
0.113


226139_at
0.0768
0.0681
0.0812
0.0512
0.0379
0.0416
0.0479
0.0536
0.14
0.0378


226308_at
0.0657
0.0263
0.01
0.01
0.01
0.0312
0.0231
0.0284
0.043
0.01


226428_at
0.153
0.0801
0.0658
0.102
0.104
0.237
0.0966
0.132
0.0753
0.0311


226616_s_at
0.236
0.348
0.323
0.327
0.228
0.229
0.174
0.255
0.24
0.377


226651_at
0.0692
0.0777
0.0542
0.0394
0.0451
0.0442
0.01
0.0595
0.0394
0.0456


226693_at
0.107
0.208
0.0793
0.199
0.198
0.117
0.094
0.0971
0.0968
0.0856


226749_at
0.129
0.182
0.114
0.309
0.132
0.185
0.144
0.147
0.219
0.311


226810_at
0.269
0.04
0.104
0.171
0.126
0.01
0.01
0.132
0.136
0.0356


226839_at
0.109
0.112
0.0696
0.142
0.082
0.13
0.0744
0.0966
0.0824
0.0389


226917_s_at
0.229
0.242
0.234
0.209
0.155
0.27
0.204
0.502
0.459
0.182


227181_at
0.0489
0.0377
0.0445
0.0729
0.0451
0.052
0.0633
0.0527
0.0932
0.08


227412_at
0.0442
0.105
0.0367
0.0473
0.0451
0.0936
0.0949
0.055
0.043
0.0511


227427_at
0.0756
0.0562
0.01
0.01
0.0215
0.0416
0.0624
0.0211
0.0466
0.0345


227472_at
0.0349
0.01
0.01
0.01
0.01
0.01
0.0308
0.01
0.01
0.01


227603_at
0.288
0.095
0.112
0.122
0.0687
0.0832
0.0975
0.223
0.129
0.188


227810_at
0.202
0.061
0.132
0.128
0.084
0.143
0.0983
0.167
0.147
0.152


227921_at
0.232
0.15
0.166
0.0808
0.084
0.0936
0.372
0.44
0.0645
0.0222


228286_at
0.0652
0.0383
0.0735
0.01
0.0266
0.0312
0.0496
0.0824
0.1
0.0689


228650_at
0.0657
0.0711
0.172
0.0966
0.0676
0.13
0.0786
0.136
0.165
0.167


228736_at
0.01
0.0233
0.01
0.01
0.0318
0.0286
0.01
0.0591
0.0538
0.0411


228930_at
0.118
0.158
0.0561
0.0847
0.0625
0.0754
0.0769
0.141
0.108
0.138


229001_at
0.01
0.127
0.01
0.01
0.0687
0.0234
0.0821
0.0444
0.0394
0.0289


229035_s_at
0.193
0.0795
0.0793
0.069
0.0933
0.0728
0.1
0.145
0.0788
0.0422


229384_at
0.114
0.0544
0.11
0.0572
0.0543
0.0858
0.119
0.0898
0.125
0.0823


229421_s_at
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.01
0.0215
0.02


229534_at
0.01
0.159
0.01
0.0414
0.0943
0.01
0.01
0.0243
0.0358
0.0989


229570_at
0.0233
0.0777
0.01
0.01
0.01
0.01
0.059
0.0215
0.0466
0.0311


230048_at
0.01
0.01
0.0329
0.01
0.01
0.026
0.0265
0.0343
0.0215
0.01


230791_at
0.933
0.0753
0.0677
0.0532
0.0369
0.0364
0.0658
0.0536
0.0896
0.0645


230922_x_at
0.0244
0.01
0.0367
0.0236
0.0277
0.0286
0.0436
0.0398
0.0573
0.0267


230983_at
0.01
0.01
0.0522
0.01
0.0369
0.0338
0.0342
0.0353
0.0323
0.03


231271_x_at
0.26
0.201
0.219
0.152
0.152
0.151
0.166
0.165
0.186
0.177


232524_x_at
0.281
0.231
0.126
0.108
0.11
0.148
0.16
0.432
0.215
0.152


232527_at
0.0361
0.1
0.01
0.0453
0.0451
0.0312
0.0504
0.0774
0.0323
0.04


233214_at
0.0873
0.0885
0.0967
0.0926
0.0615
0.0598
0.0881
0.136
0.129
0.0711


233302_at
0.0477
0.0466
0.01
0.01
0.0236
0.0754
0.0966
0.0696
0.0215
0.01


233429_at
0.01
0.01
0.114
0.0315
0.0246
0.01
0.0368
0.01
0.0215
0.01


233440_at
0.0471
0.0293
0.0232
0.0315
0.0277
0.0754
0.0214
0.0302
0.0573
0.0489


233493_at
0.01
0.01
0.0213
0.01
0.01
0.0208
0.0325
0.027
0.0645
0.0222


233599_at
0.01
0.01
0.01
0.01
0.01
0.01
0.0385
0.0215
0.0215
0.01


234735_s_at
0.196
0.102
0.0696
0.0907
0.0758
0.0442
0.123
0.0357
0.0609
0.0611


235363_at
0.0873
0.052
0.06
0.0611
0.0523
0.0442
0.0521
0.0865
0.0681
0.0734


235467_s_at
0.0605
0.01
0.01
0.01
0.0266
0.0468
0.0256
0.0444
0.01
0.0278


235634_at
0.0221
0.0341
0.0793
0.0631
0.0215
0.0442
0.0333
0.027
0.0251
0.0333


236312_at
0.01
0.01
0.0464
0.01
0.0728
0.039
0.0291
0.0417
0.0466
0.04


236875_at
0.01
0.01
0.029
0.01
0.01
0.01
0.0419
0.01
0.01
0.01


237023_at
0.0273
0.0329
0.0522
0.01
0.042
0.0468
0.0436
0.01
0.0466
0.0489


239496_at
0.0343
0.01
0.01
0.0611
0.0287
0.0338
0.0231
0.0353
0.0358
0.0222


240130_at
0.01
0.01
0.06
0.0296
0.01
0.0234
0.0359
0.0201
0.01
0.01


241395_at
0.039
0.01
0.0271
0.01
0.01
0.0234
0.0222
0.044
0.01
0.01


242171_at
0.0262
0.01
0.01
0.0335
0.0277
0.039
0.0342
0.0302
0.0394
0.0211


242602_x_at
0.0506
0.0544
0.0445
0.0985
0.0543
0.0858
0.0564
0.0545
0.0502
0.0389


242606_at
0.01
0.01
0.0426
0.0355
0.0523
0.026
0.0436
0.0243
0.0466
0.0267


243003_at
0.0873
0.0909
0.0909
0.0769
0.0215
0.0832
0.1
0.145
0.1
0.108


243185_at
0.01
0.0209
0.01
0.01
0.01
0.0208
0.0496
0.0467
0.0538
0.0322


31826_at
0.0346
0.0944
0.115
0.0822
0.144
0.102
0.0966
0.115
0.14
0.135


35150_at
0.0422
0.0297
0.129
0.106
0.0844
0.0606
0.0543
0.0608
0.0886
0.074


64474_g_at
0.0522
0.0489
0.0636
0.0394
0.0757
0.0979
0.0752
0.0438
0.0468
0.0729


91617_at
0.0411
0.0325
0.0413
0.0259
0.0552
0.0585
0.0504
0.045
0.0769
0.062



















LXFE_397,
LXFE_646,
LXFL_1072,
MAXF_574,
MAXF_857,
RXF_393,



Systematic
Avastin_p R
Avastin_p R
Avastin_p R
Avastin_p R
Avastin_p R
Avastin_p R



Name
normalized
normalized
normalized
normalized
normalized
normalized






200076_s_at
0.155
0.0921
0.142
0.185
0.277
0.294



200631_s_at
1.147
0.725
0.764
0.735
0.676
0.654



201722_s_at
0.125
0.408
0.0518
0.121
0.0265
0.0761



201919_at
0.387
0.392
0.233
0.314
0.188
0.356



202333_s_at
0.103
0.253
0.125
0.684
0.0617
0.131



202758_s_at
0.0632
0.0714
0.0246
0.138
0.0702
0.0562



203092_at
0.0756
0.0472
0.0202
0.105
0.0899
0.0551



203846_at
0.16
0.0786
0.0884
0.0969
0.0514
0.0902



205042_at
0.03
0.0309
0.0567
0.115
0.0428
0.048



205046_at
0.0727
0.0665
0.122
0.0885
0.11
0.0726



205105_at
0.322
0.0613
0.06
0.137
0.0908
0.0609



205481_at
0.01
0.01
0.01
0.01
0.01
0.01



206003_at
0.0355
0.044
0.0333
0.0346
0.0283
0.0246



208369_s_at
0.0436
0.0499
0.0316
0.103
0.0711
0.0375



208848_at
0.244
0.143
0.0775
0.099
0.0796
0.0914



208951_at
0.01
0.01
0.0491
0.143
0.0411
0.0597



209161_at
0.241
0.121
0.149
0.272
0.119
0.11



209758_s_at
0.01
0.01
0.01
0.01
0.01
0.01



211974_x_at
0.337
0.168
0.465
0.228
0.258
0.26



211976_at
0.125
0.125
0.148
0.134
0.184
0.114



212394_at
0.01
0.01
0.01
0.036
0.0214
0.0422



213677_s_at
0.132
0.103
0.0857
0.192
0.0702
0.155



214086_s_at
0.134
0.146
0.0627
0.119
0.0788
0.0668



214585_s_at
0.202
0.191
0.211
0.225
0.168
0.2



214672_at
0.0895
0.0525
0.0567
0.0927
0.11
0.0984



214844_s_at
0.01
0.01
0.01
0.0212
0.0223
0.0363



217797_at
0.114
0.359
0.165
0.543
0.222
0.245



217895_at
0.179
0.158
0.0878
0.227
0.157
0.0879



218625_at
0.383
0.0496
0.01
0.01
0.01
0.0679



218768_at
0.33
0.206
0.282
0.367
0.259
0.185



218818_at
0.0227
0.025
0.01
0.0317
0.03
0.048



218998_at
0.199
0.0789
0.172
0.187
0.0762
0.18



219595_at
0.0562
0.0414
0.0813
0.0523
0.0565
0.0527



219906_at
0.0291
0.01
0.01
0.01
0.01
0.01



221214_s_at
0.0504
0.083
0.024
0.0364
0.0308
0.0633



221249_s_at
0.144
0.121
0.0813
0.0432
0.0839
0.01



222587_s_at
0.0672
0.0588
0.126
0.208
0.0369
0.0556



222612_at
0.0429
0.0252
0.0621
0.0212
0.029
0.0571



222775_s_at
0.109
0.0953
0.0975
0.0795
0.0824
0.0893



222807_at
0.155
0.137
0.045
0.0339
0.0612
0.0864



222906_at
0.186
0.0329
0.0737
0.0339
0.0675
0.0674



223175_s_at
0.0756
0.0715
0.0532
0.0583
0.0926
0.0703



223197_s_at
0.189
0.0907
0.187
0.0805
0.164
0.105



223206_s_at
0.0999
0.127
0.106
0.0941
0.243
0.0615



223448_x_at
0.474
0.124
0.202
0.132
0.228
0.274



223470_at
0.154
0.0811
0.0477
0.0924
0.0997
0.0674



223518_at
0.0928
0.072
0.0805
0.0696
0.194
0.0952



223528_s_at
0.173
0.112
0.115
0.0652
0.4
0.122



223570_at
0.0539
0.0318
0.0648
0.0473
0.0589
0.0615



224473_x_at
0.0787
0.0507
0.0798
0.0488
0.0934
0.195



224721_at
0.145
0.122
0.121
0.131
0.0997
0.173



225025_at
0.0552
0.0467
0.0559
0.0414
0.13
0.0659



225097_at
0.575
0.12
0.111
0.0838
0.294
0.338



225506_at
0.0875
0.0549
0.0996
0.0293
0.199
0.108



225554_s_at
0.417
0.0841
0.4
0.122
0.488
0.164



225584_at
0.0822
0.0494
0.0737
0.0799
0.0424
0.0864



225841_at
0.0747
0.119
0.028
0.156
0.297
0.0322



225947_at
0.285
0.235
0.568
0.365
0.393
0.258



226124_at
0.133
0.0781
0.285
0.0545
0.108
0.0893



226139_at
0.0398
0.01
0.0471
0.0327
0.044
0.0556



226308_at
0.0623
0.0309
0.01
0.038
0.051
0.0322



226428_at
0.123
0.0593
0.0887
0.0492
0.191
0.196



226616_s_at
0.25
0.0476
0.223
0.121
0.247
0.209



226651_at
0.0592
0.035
0.0498
0.0322
0.0267
0.01



226693_at
0.198
0.0926
0.0996
0.0279
0.0864
0.105



226749_at
0.255
0.103
0.207
0.0852
0.196
0.195



226810_at
0.0597
0.354
0.252
0.111
0.0777
0.262



226839_at
0.099
0.0628
0.0662
0.156
0.201
0.11



226917_s_at
0.3
0.119
0.306
0.144
0.298
0.133



227181_at
0.139
0.01
0.0675
0.0694
0.178
0.0586



227412_at
0.0517
0.0245
0.043
0.0306
0.0777
0.0498



227427_at
0.023
0.0238
0.01
0.01
0.0495
0.0366



227472_at
0.023
0.01
0.0259
0.01
0.0534
0.0586



227603_at
0.113
0.0244
0.111
0.0895
0.206
0.101



227810_at
0.175
0.109
0.108
0.144
0.122
0.24



227921_at
0.328
0.0815
0.0934
0.0552
0.188
0.252



228286_at
0.105
0.0706
0.0553
0.0562
0.051
0.063



228650_at
0.211
0.0864
0.117
0.122
0.115
0.0937



228736_at
0.0376
0.043
0.01
0.0268
0.044
0.0264



228930_at
0.099
0.0655
0.0805
0.0624
0.0801
0.0805



229001_at
0.0756
0.0355
0.0409
0.0262
0.0636
0.01



229035_s_at
0.0844
0.0263
0.0675
0.0439
0.168
0.0981



229384_at
0.0999
0.0389
0.0682
0.0469
0.111
0.119



229421_s_at
0.01
0.01
0.01
0.01
0.01
0.01



229534_at
0.0208
0.0232
0.01
0.0217
0.01
0.01



229570_at
0.01
0.01
0.0416
0.01
0.01
0.01



230048_at
0.01
0.0205
0.0218
0.0204
0.022
0.0293



230791_at
0.01
0.01
0.0894
0.0417
0.0636
0.0688



230922_x_at
0.034
0.0296
0.0375
0.0456
0.0408
0.063



230983_at
0.0309
0.0255
0.043
0.134
0.0408
0.0395



231271_x_at
0.155
0.108
0.164
0.0903
0.225
0.0556



232524_x_at
0.247
0.104
0.32
0.16
0.277
0.108



232527_at
0.0517
0.01
0.0477
0.0352
0.0204
0.022



233214_at
0.132
0.03
0.0859
0.0403
0.0958
0.107



233302_at
0.0283
0.0261
0.01
0.02
0.0432
0.01



233429_at
0.01
0.01
0.01
0.01
0.01
0.0205



233440_at
0.0473
0.01
0.06
0.01
0.0314
0.0351



233493_at
0.0217
0.01
0.0246
0.01
0.0204
0.0205



233599_at
0.023
0.0253
0.01
0.01
0.01
0.01



234735_s_at
0.0981
0.0374
0.0477
0.0228
0.118
0.022



235363_at
0.153
0.01
0.0982
0.0953
0.0699
0.0732



235467_s_at
0.01
0.01
0.01
0.0218
0.01
0.0249



235634_at
0.0283
0.01
0.0355
0.023
0.0243
0.0483



236312_at
0.0751
0.047
0.0307
0.029
0.0699
0.0293



236875_at
0.01
0.01
0.01
0.01
0.01
0.01



237023_at
0.0482
0.01
0.0246
0.0257
0.0345
0.0381



239496_at
0.01
0.01
0.0382
0.01
0.0448
0.0542



240130_at
0.01
0.01
0.0232
0.01
0.0212
0.0264



241395_at
0.01
0.01
0.01
0.01
0.022
0.0234



242171_at
0.0371
0.01
0.0259
0.0202
0.0377
0.0249



242602_x_at
0.0407
0.0205
0.0709
0.0684
0.0534
0.0674



242606_at
0.0522
0.0293
0.0239
0.0239
0.0314
0.0337



243003_at
0.0623
0.0216
0.117
0.0249
0.283
0.119



243185_at
0.01
0.01
0.0273
0.01
0.01
0.0293



31826_at
0.101
0.0888
0.0987
0.161
0.0925
0.142



35150_at
0.0645
0.0651
0.0617
0.0868
0.0668
0.108



64474_g_at
0.0792
0.156
0.0366
0.081
0.0625
0.0668



91617_at
0.0523
0.119
0.03
0.0643
0.0668
0.0679



















TABLE 2









BXF
Bladder cancer



CEXF
Cancer of the uterine cervix



CNXF
Cancer of the central nervous




system



CXF
Colon cancer



GXF
Gastric cancer



HNXF
Head and neck cancer



LEXF
Leukemia



LXFA
Non small cell lung cancer, adeno



LXFE
Non small cell lung cancer,




epidermoid



LXFL
Non small cell lung cancer, large




cell



LXFS
Small cell lung cancer,



LYXF
Lymphom cancer



MAXF
Mammary cancer



MEXF
Melanoma



OEXF
Esophageal cancer



OVXF
Ovarian cancer



PAXF
Pancreatic cancer



PRXF
Prostate cancer



PXF
Pleuramesothelioma



RXF
Renal cancer



SXF
Sarcoma



TXF
Testicular cancer



UXF
Cancer of the uterine body



XF
Various histologies



HLXF
Hodgkin lymphom



NLXF
Non Hodgkin lymphom




















TABLE 3






Organism




Probe
Common
Sequence



Set ID
Name
Description
Target Sequence







200076_s_at
Human
/DEF = Homosapiens,
ccattccagctggagtcgtggggctgggcacaggggaatttttccagagctgagcc


(SEQ. ID. No.

hypothetical protein
tgacgtctgctctgaagaatgcttagaaggttcccagacaccagagccagatgtcc


1)

MGC2749, clone
cccaccaccggtcaggacctccttgaggtgcacaagcacggtctcctctgagttca




MGC:4376, mRNA, 
ccccagcccacccccgcacccactaattctgcttttcctgccccttgctccgtaaa




complete cds.
agtatcaaatactttctccttggtatctcaaggaggtttctgagataggtagaagt




/PROD = hypothetical
cttgagacggaggctggccatccattcagccctgagcgtgctgagttctgtgtttc




protein MGC2749
tctgaatagaggtgtggaacctgaggggccagcaggcctctctgaaggcctccatg





gagcaaacggagccacctcgggaaagagtttaatggaatatttttgtacccgatgt





ttacagatgctgtt





200631_s_at
Human
/DEF = Homosapiens
agacctggtgctctaatgccaagttatacacgggacagttgctggcatgtcttcat


(SEQ. ID. No.

SET translocation
tggctctctaaaatgtggccaagaagataggctctcagtaagaagtctgatggtga


2)

(myeloid leukemia-
gcagtaactgtccctgctttctggtataaagctctcaaatgtgaccatgtgaatct




associated) (SET), 
gggtgggataatggactcagctctgtctgctcaatgccattgtgcagagaagcacc




mRNA.
ctaatgcataagcntaatgctgtaaaatatagtcgctgaaattaaatgccactttt




/GEN = SET
tcagaggtgaattaatggacagtctggtgaacttcaaaagctttttgatgtataaa




/PROD = SET
acttgataaatggaactattccatcaataggcaaaagtgtaacaacctatctagat




translocation
ggatagtatgtaatttctgcacaggtctctgtttagtaaatacatcactgtatacc




(myeloid leukemia-
gatcaggaatcttgctccaa




associated)






201722_s_at
Human
/DB_XREF = AV692127
attttgattcatctgtgatagtcatggatgcttttattttccttggggtgctgaa


(SEQ. ID. No.

/CLONE = GKCAOB04
attgagctgaaaaaaaaaggctctttgaatatagttttaatttctctctacagtt


3)


ttttttgtttggtttgtgggctgaggaattgtaatttttaattgccttctaaaaa





atggaaatttaacaatgtctgatctcagctgaacaaattagatgtttcagttgct





cttgggtcaactggcttacagatttacatgtgcacacacacacaaatttcttatc





acattttcgacttcttcacttgacctaactgattatgcgaaatacccaagattca





tgctactgtaccacagatttgttttcacagcaataaatcttcagttctgttgttt





atgattccacttaacaaaaggcctgcagaagtgatttattatttgggtatttgga





gataatacatttgatggtatttggaaaacctttttcactccatactcagatatgc





ttcattgtcaaatgcatatttagattagattattgaattgtaatgtttatctgct





gctttt





201919_at
Human
/DB_XREF = wp03g05.x1
atccatttcttgcccttcaataattgtccatgcctgccttttgttgtttacatgc


(SEQ. ID. No.

/CLONE = IMAGE:
tcttctgcccagactgttagtaatctagggaccccctttggagctgataagtaca


4)

2463800
gttcagccttttctcctcaaatatataatganctttaacattcctaagaatatag





gtatttctgaatgatttaaatttgaggaattttaatacataaaatacaatgtaca





aactttctgcccactcagatctcttctccatcatgtacttagtatttcccattaa





cctacacactgatttttatgctactccttgtagaaacaaaattctggtttgactc





agtttttgtgtttataaacttttggaatgtgtaccccgtttatgtgaag





202333_s_at
Human
/DB_XREF = wh25c12.x1
ggctcatgcgggatttcaagccttaccagaggacccacctgttgctgtcagtggc


(SEQ. ID. No.

/CLONE = IMAGE:
gcaccatctgaaaacaacatcatgcagtggaatgcagttatatttggaccagaag


5)

2381782
ggacaccttttgaagatggtacttttaaactagtaatagaattttctgaagaata





tccaaataaaccaccaactgttaggtttttatccaaaatgtttcatccaaatgtg





tatgctgatggtagcatatgtttagatatccttcagaatcgatggagtccaacat





atgatgtatcttctatcttaacatcaattcagtctctgctggatgaaccgaatcc





taacagtccagccaatagccaggcagcacagctttatcaggaaaacaaacgagaa





tatgagaaaagagtttcggccattgttgaacaaagctggaatgattcataataga





caactggtctgttaatctttttcatcattgttgtgtataatttacctctcatta





202758_s_at
Human
/DEF = Homosapiens
gtgacaacctcgtcaacaagccagacgagcgcggcttcacccccctcatctgggc


(SEQ. ID. No.

regulatory factor
ctccgcctttggagagattgagaccgttcgcttcctgctggagtggggtgccgac


6)

X-associated
ccccacatcctggcaaaagagcgagagagcgccctgtcgctggccagcacaggcg




ankyrin-containing
gctacacagacattgtggggctgctgctggagcgtgacgtggacatcaacatcta




protein (RFXANK),
tgattggaatggagggacgccactgctgtacgctgtgcgcgggaaccacgtgaaa




mRNA.
tgcgttgaggccttgctggcccgaggcgctgacctcaccaccgaagccgactctg




/GEN = RFXANK
gctacaccccgatggaccttgccgtggccctgggataccggaaagtgca




/PROD = regulator y 





factor X-associated 





ankyrin-containing 





protein






203092_at
Human
/DEF = Homosapiens
ggcaactccagacctctgggaacaagactgcgggctctgcccccagctctgccag


(SEQ. ID. No.

putative mitochondrial
gacggctgcaagaccagctggcccgggaggggacaacgggctgttgcgggtgcgc


7)

inner membrane
ggcagctggagacactcccccgcagggccaacccctgccctgttgctctgccctg




protein import
caggggtcccggcgcatggtcacctggggtgcacacaggtcacacagtgccaaga




receptor (hTIM44)
ggccccagggcccagggactccccccacagcagggtgggacccgggacccgcggc




mRNA, nuclear gene
tcagtggcccgctagccacgtcagccaagccactttaggtccattttttaatttt




encoding mitochondrial
aacagtgctcttccatcttgtgcataagcctgagatttggaaagaataaaacacc




protein, complete cds.
gaattgcagaaga




/GEN = hTIM44





/PROD = putative





mitochondrial inner 





membrane proteinimport





receptor






203846_at
Human
/DEF = Homosapiens,
tgctccacctttcagtgacatttaagacatcatattcccgtaacattatgtctc


(SEQ. ID. No.

TAT-INTERACTIVE
agtctgatcgtctttaccagtatgaaagtcattcatttagtgctaccaaagggg


8)

PROTEIN, 72-KD, clone 
atacacaagccctttaggaagcagtacctctcgcctggaggatctgtgccatct




MGC: 4116, mRNA, 
tggattgagaattgcagatgtgacagaatggattgaccctagttggttggtatt




complete cds.
gatgacttcagcctggaaattgcttgccttttaaagaagcatatatgggttgga




/PROD = TAT-
attatgccaaagcataggaagctgggaataagcaaacaaatgctgatatagtca




INTERACTIVE
gcaaatttggatagtctctagggctcatcatttttcatactacctctctcttct




PROTEIN, 72-
ggcctgtgtctaaggaattgtacaacataggccagggccaacaaagtggagagg





tggacacattttcatgttcattactaaaacaaacagcaaaactattggtttgtt





attctgtgttttcctcaagtcagtacatactatttggtttcaggatttctttcc





atttctctatcaagcatt





205042_at
Human
/DEF = Homosapiens
ttacatttgaactatatccttcctagtgggttagtgtgaaaaagagtttggctg


(SEQ. ID. No.

UDP-N-
attcctaaaactctgccagccctgcagtaatctccaggcctggttattgttcag


9)

acetyiglucosamine-
acattccatggtgattcctgggaaggaagcttggctgctcagtttctgagtctg




2-epimeraseN-
gggtgagataatgttctggaaggacatctgttctttggtgtaatctctcatggt




acetylmannosamine 
gaaatctgctctgtacatcagacaattgcattgctaccaagtttcataccaa




kinase (GNE), mRNA.





/GEN = GNE/





PROD = UDP-N-





acetyiglucosamine-





2-epimeraseN-





acetylmannosamine





kinase






205046_at
Human
/DEF = Homosapiens
aatcagcatctttccaatgaggtcaaaacttggaaggaaagaacccttaaaagag


(SEQ. ID. No.

centromere protein
aggctcacaaacaagtaacttgtgagaattctccaaagtctcctaaagtgactgg


10)

E (312 kD) (CENPE),
aacagcttctaaaaagaaacaaattacaccctctcaatgcaaggaacggaattta




mRNA.
caagatcctgtgccaaaggaatcaccaaaatcttgtttttttgatagccgatcaa




/GEN = CENPE
agtctttaccatcacctcatccagttcgctattttgataactcaagtttaggcct




/PROD = centromere
ttgtccagaggtgcaaaatgcaggagcagagagtgtggattctcagccaggtcct




protein E
tggcacgcctcctcaggcaaggatgtgcctgagtgcaaaactcagtagactcctc





tttgtcacttctctggagatccagcattccttatttggaaatgactttgtttatg





tgtctatccctggtaatgatgttgtagtgcagcttaatttcaattcagtctttac





tttgccactag





205105_at
Human
/DEF = Homosapiens
acttcttctctcatgaatcatccagtcattccaatggcaaataagttctcaccta


(SEQ. ID. No.

mannosidase,
cccttgagctgcaaggtgaattctctccattacagtcatctttgccttgtgacat


11)

alpha, class 2A,
tcatctggttaatttgagaacaatacagtcaaaggtgggcaatgggcactccaat




member 1 (MAN2A1),
gaggcagccttgatcctccacagaaaagggtttgattgtcggttctctagcaaag




mRNA.
gcacagggctgttttgttctactactcagggaaagatattggtacagaaactttt




/GEN = MAN2A1
aaacaagtttattgtcgaaagtctcacaccttcatcactatccttgatgcattca




/PROD = mannosidase,
cctcccggcactcagaatataagtgagatcaacttgagtccaatggaaatcagca




alpha, class 2A,
cattccgaatccagttgaggtgaacctgactttcacatttggattgagaatcatt




member 1
ggcttttatacctttcttggt





205481_at
Human
/DEF = Homosapiens
gaggagaacactagacatgccaactcgggagcattctgcctgcctgggaacgggg


(SEQ. ID. No.

adenosine A1
tggacgagggagtgtctgtaaggactcagtgttgactgtaggcgcccctggggtg


12)

receptor (ADORA1),
ggtttagcaggctgcagcaggcagaggaggagtacccccctgagagcatgtgggg




mRNA.
gaaggccttgctgtcatgtgaatccctcaatacccctagtatctggctgggtttt




/GEN = ADORA1
caggggctttggaagctctgttgcaggtgtccgggggtctaggactttagggatc




/PROD = adenosine A1
tgggatctggggaaggaccaacccatgccctgccaagcctggagcccctgtgttg




receptor
gggggcaaggtgggggagcctggagcccctgtgtgggagggcgaggcgggggagc





ctggagcccctgtgtgggagggcgaggcgggggatcctggagcccctgtgtcggg





gggcgagggaggggaggtggccgtcggttgaccttctgaacatgagtgtcaactc





caggacttgcttccaagcccttccctctgttggaaattgggtgtgccctggctcc





206003_at
Human
/DEF = Homosapiens
ctttttcttctaagcctgtgtgttataatttaccagttccccaaaatgccatttt


(SEQ. ID. No.

KIAA0635 gene
taacgccgaactgtgtaatatacatggaaaacagctttttacaattaattttcaa


13)

product (KIAA0635),
agttgtaattttaaagaatttgggtgtatacctatgttaatgaaacaacagaagt




mRNA.
acaaaaaagaatatcagatacaaaaatcaatcgtgaagaaaatctgttcttaata




/GEN = KIAA0635
tatttcattatgattgaaaaacataaaaactaacataggaaagtgaatgatcagt




/PROD = KIAA063
tacttatgatatattttgtttcctcttgtggtttaataaagtgaagtgtgtgtgt




5 gene product
gtgtgtgtgtgtgtgtgtgtgtgtatacctgggggtgggcagtgctctttttcta





aaactaatatggcttatatatctgaattatgccctttttagtgtgtattaggatg





tgggctggtttgcttttctaccacctttgtaattttatgtatcccatctcctttg





tgtgaattcatatattatagcaaaatacaagagacatgggactgtttgcaatac





208369 s_at
Human
/DEF = Homosapiens
tacgccctcgacaggatgcagtttggtgtcccactggccaggaaccagctgattc


(SEQ. ID. No.

glutaryl-Coenzyme A
agaagaagctggcagacatgctcactgagattaccctgggccttcacgcctgcct


14)

dehydrogenase
gcagctcggccgcttgaaggaccaggacaaggctgcccccgagatggtttctctg




(GCDH), nuclear
ctgaagaggaataactgtgggaaagccctggacatcgcccgccaggcccgagaca




gene encoding
tgctgggggggaatgggatttctgacgagtatcacgtgatccggcacgccatgaa




mitochondrial
cctggaggccgtgaacacctacgaagtcgttcagatgtgttccttaaaaagaaga




protein, transcript
tggaattctctgtagagcgtctcaatccacttttaaccatggatgagagcagact




variant 2, mRNA.
ccatttaccctgaaatagcagcttctcttgagaggagagtgacatggaagcaact




/GEN = GCDH
ccgtctgctgcagctgaccccctcacactgagttcacagtgcgccctccctccct




/PROD = glutaryl-
cccatctgggggtagtgccttatgctgg




Coenzyme A





dehydrogenase





isoform b






208848_at
Human
/DEF = Human
gttggttgtgactgtactattctagtatagtgaactacatactgaatatccaagt


(SEQ. ID. No.

class III alcohol
tctcagcacctacttttgtcaaatcttaacattttgccacttcgagatcacattg


15)

dehydrogenase (ADH5) 
ccttcctcccctccaagaggtaacaattatccacaatttgatgtttatcattcct




chi subunit mRNA,
gtgttgttgtactttcactgtgtataacctaaaccatctactctttagtactgtt




complete cds.
ttatatatttttaagcctcatacttgctcattctacagcttttttcactcattat




/GEN = ADH5
tgtataattatatctgaagctctcgttcattaattttagtcctgtgtagcagaat




/PROD = alcohol
tcaattacgggaaactaccataatttatctgttctccagtccagttgaaggcatg




dehydrogenase 3
aagttgttgccagtttctgtattataacactgtagtggaacattcttctgcattg





ggctactcgcgtgttacctaagacgt





208951_at
Human
/DEF = Homosapiens,
gtggcacagtggtctatgggggcaaggttatggatcgccctggaaattatgtaga


(SEQ. ID. No.

antiquitin 1, clone
accgacaattgtgacaggtcttggccacgatgcgtccattgcacacacagagact


16)

MGC: 1569,
tttgctccgattctctatgtctttaaattccag




mRNA, complete cds.





/PROD = antiquitin 1






209161_at
Human
/DB_XREF = qd24g04.xl
tgttcgaatgccttatagccttcctcacagcacccaggattgtgactgactctgc


(SEQ. ID. No.

/CLONE  IMAGE:
atttttaattcttgaaacttggctttccataacatggtacatgcttcaggactac


17)

1724694
atatgacccagagagcaaggtggctgaactatagtctggaagccctcaggtaaag





aggcacatctcaccactcattggttaaacaatgcatcatagcgagcacttttcct





ttccctggagaatgggatgtgaagcagtagaccgcagccacgccgatggttatac





agtgaagaagacttcacctcttcctattgagtttgcttggaatgctgacagcatc





aggcaactctgaactgaacatttgctttgtcagaaaatatctttttttttacttt





gaagtttggcaaccttcatgttaccccaaagcaaaaccattgtgtcaggagtcaa





acaaatgtttagaaagcaaacatgacgtctctattgtacaacctcc





209758_s_at
Human
/DEF = Human
taatctggtgaatgatcccgctacagatgaaacagttttggctgttttggctgat


(SEQ. ID. No.

microfibril-
attgcaccttccacagatgacttggcctccctcagtgaaaaaaataccactgcag


18)

associated
agtgctgggatgagaaatttacctgcacaaggctctactctgtgcatcggccggt




glycoprotein-2 MAGP-2 
taaacaatgcattcatcagttatgcttcaccagtttacgacgtatgtacatcgtc




mRNA, complete cds.
aacaaggagatctgctctcgtcttgtctgtaaggaacacgaagctatgaaagatg




/PROD = microfibril-
agctttgccgtcagatggctggtctgccccctaggagactccgtcgctccaatta




associated
cttccgacttcctccctgtgaaaatgtggatttgcagagacccaatggtctgtga




glycoprotein-2 MAGP-2
tcattgaaaaagaggaaagaagaaaaaatgtatgggtgagaggaaggaggatctc





cttcttctccaaccattgacagctaacccttagacagtatttcttaaaccaatcc





ttttgcaatgtccagctt





211974_x_at
Human
/DB_XREF = AL513759
gagagagtatgctctgtgtcgtcccagacatttctgcattccgagaaggttggag


(SEQ. ID. No.

/CLONE = CL0BA008ZD02
atgggtccggcaaccagtccaggttccagtaactttggtccgaaatgatggaatc


19)

(3 prime)
atttattccaccagccttacctttacctacacaccagaaccagggccgcggccac





attgcagtgcagcaggagcaatccttcgagccaattcaagccaggtgccccctaa





cgaatcaaacacaaacagcgagggaagttacacaaacgccagcacaaattcaacc





agtgtcacatcatctacagccacagtggtatcctaactaccgtctttttgctagg





acttaaactgacttgagtgtggcaaaaagttaacaaaaaaggagaaaaaatgaac





aatcgtttgtggtttcttgggaaaacttttcataccaggtgatactattcaaaaa





ccccgttgtctccctgcaagtgctgatttg





211976_at
Human
/DB_XREF = xz95g12.x1
tgtcttcacagcgtccctaaggaagatttttgcagcactctctggagctgagggg


(SEQ. ID. No.

/CLONE = IMAGE:
agtgaaatttggtccagagaaggcggaaggaaatagttttcctgtttccttttct


20)

2872006
cgaggtggatgtcctcaggcttccttcacacctccttctcatgggtncggntggc





agtacagtcaggctgtggaggagggctgagaagaaaggggcactggtccagcccc





anggtttggtctgagacaggtacacagcagataccatcccaccttcctctctaaa





gaacaggccagccacacatataaccctttccctactttactaatgtatcccttat





gtggtaccagcaatggaggacaggcagacttaccccctgccatctagagagaatg





ttgttattacccgtaaaacttgaccacccccatatcccactcctttttgtaaaaa





caaatgcttaaacctgtgagcctgccgttcctttctatgtgttaatcagtttcct





tccatttgagctgt





212394_at
Human
/DEF = Human mRNA for
gcacctggcccataaattgtcatacttttaaagagcctattacacaaagtatcat


(SEQ. ID. No.

KIAA0090 gene,
cagaatcatcccaagactcatttcctgattcctaattatttaaaattttgctttt


21)

partial cds.
aggcgaggcatggtgnctcaagcctatnntcccagcactttgggagncnaaggca




/GEN = KIAA0090
ggcagatcatttgaggtcaggagtttnngaccagcctggccaacatggtgaaacc





tgaaaccccatctctaccaaaaaaatggaaaaatttagccaggtgtggtggtgca





tgcctgtaatcccagcctcccgagtagctggggctcaggcgtgcgccaccatgcc





cggctaatttttgtatatttatggaaatgccaagagatagttcaatctgcctctc





tggcaagccatggacaccaggtctgacaaactctcttactccttaagacaaatgc





tcacctgatcaatatggggaaataagctgcatggtaccataatttctattctaaa





agggaaaagtatctctttggtattgctttggaa





213677_s_at
Human
/DB_XREF = 602507842F1
gatcaacttacctgtctgatcctcgtcttacagcgaatggtttcaagataaaatt


(SEQ. ID. No.

/CLONE = IMAGE: 
gataccaggagtttcaattactgaaaattacttggaaatagaaggaatggctaat


22)

4604891
tgtctcccattctatggagtagcagatttaaaagaaattcttaatgctatattaa





acagaaatgcaaaggaagtttatgaatgtagacctcgcaaagtgataagttattt





agagggagaagcagtgcgtctatccagacaattacccatgtacttatcaaaagag





gacatccaagacattatctacagaatgaagcaccagtttggaaatgaaattaaag





agtgtgttcatggtcgcccattttttcatcatttaacctatcttccagaaactac





atgattaaatatgtttaagaagattagttaccattgaaattggttctgtcataaa





acagcatgagtctggttttaaattatctttgtattatgtgtcacatggttatttt





ttaaatgaggattcactgacttgttttt





214086_s_at
Human
/DEF = Homosapiens
gacatgtcttccaagagtgccaattactgcttnnnnnnncgcctaaagnatacag


(SEQ. ID. No.

cDNA FLJ11118 fis,
gactgctgctcttatcagnngtagctctaggtcagtgtaatgaactactagaggc


23)

clone PLACE1006011,
caatcctaaggccgaaggattgcttcaaggtaaacatagcaccaaggggctgggc




highly similar to
aagatggctcccagttctgcccacttcgtcaccctgtaagtactcagaaccagga





Homosapiens

ggactagaagactccttttggccagataagactacgttctctattgcagcttctg




mRNA for
aaccagagactgatgttgacacactttttttccatttggcaggaatgggagtaca




poly(ADP-ribose)
gtgccattaggaccagcaagtgacacaggaattctgaatccagatggttataccc




polymerase-2.
tcaactacaatgaatatattgtatataaccccaaccaggtccgtatgcggtacct





tttaaaggttcagtttaatttccttcagctgtggtga





214585_s_at
Human
/DEF = Homosapiens
ttctgatgtgccagaaaccgccctgagatctgccggtcatctccatggacttctg


(SEQ. ID. No.

mRNA; cDNA 
caccccattccatacccttcttcacctggggtaccccttccagttttccccttgc


24)

DKFZp547l194
ttcccaggcccttgacatggcttacctgccttcactcccagcaccttgcccaaca




(from clone
ggataagctggatccccttggccttctgaatatcccagtgtcttcaggtttccca




DKFZp547l194).
agaccacttccctgtgggcttccaaaatggcctttatcatttctccagtctgtca




/GEN = DKFZp547l194
ccctcctttcctgctcccatacacccaaggcttgtttcttcccctgtaaaaacca




/PROD = hypothetical 
ctgcctcaatctctggttcactcaactagtcaccatgtcctgaggcatgaagcct




protein
cctcagctcttggaattgctggcaaggggtgactgcctctgagtcattgtgtttt





tcaaagtgatttcttttctgtagctttttgacctaagatctcagcaatttgaaca





ctaacctctcccctcctggctcaagaattactccgaagtcagtctgcag





214672_at
Human
/DEF = Homosapiens
tgaagcatccaccagcacttcaaggggtccatagtatttttttttttgctgcctc


(SEQ. ID. No.

mRNA for KIAA0998
aaagtccccaaagccttcgagcagaagtggcagtagatggttgccaatcagccaa


25)

protein, partial cds.
tgcagactttcactgggacaacaagaaagcagatcttctgggttttgatggaact




/GEN = KIAA0998
tggcagtggggacattcagctgatgcattatataccccgtcagagcacacttgta




/PROD = KIAA099
tcttttaccttccctttgccccatgcccccaaactgcttaggtcttctctgtccc




8 protein
tttactgctgctgcacagagatgatataaaagaggctctttggctatttgcattn





tgcttcctcttcttttccagattacagtatgaagctttattttctttgtacaagc





ttaaaatttcaacatcatcatccgccaaagttgttcctcccttttcggaggatct





agggggaaagaggagcattcatcacaagtttcctagagagaggagacaaatcggt





gtgccattgacaacatgagccagggtaaaggcaccctttgg





214844_s_at
Human
/DEF = Homosapiens
gtcctggctaattgtgtggtcattggaaaactctgcaatacaataattttcttta


(SEQ. ID. No.

mRNA; cDNA
ttttctttttcttttttaaattcttagtgtaattgaaacgtgctctatagatatt


26)

DKFZp566A0946 (from 
gactctgtgttccctcttttacagctggacagaaagaagtcaatgtcacgaaatg




clone DKFZp566A0946);
attttctattgtagatactttgtcccttgcacttctctgaatctgtccttttgtg




partial cds.
gattcttgtgattttccttccaagtgtttcagttgtatgacagtcagtattgaca




/GEN = DKFZp566A0946
ataaaatggcttttaattatttgttatttgtttacaccctattcctcagttatta




/PROD = hypothetical
ttactgtggttctgattaactactggaaattatatttgattatatcaccaattag




protein
ttaaatcagtgcttcgactcactcttatctgttctgttcaaaactatttgttcaa





agaacccgttagtgttgtttacagggttacagtttctctcacatgctttcctcac





cccnttaccccnctttttgaaagcctttattttgttcggagtctctt





217797_at
Human
/DEF = Homosapiens
atgcctgacggatcatttcaaacctttgtgggccaggaatgtgcccaaatttgga


(SEQ. ID. No.

hypothetical protein
ctagctcatctcatggctctggggctgggtccatggctggcagtggaaatccctg


27)

(HSPC155), mRNA.
atctgattcagaagggcgtcatccaccacaaagagaaatgcaaccaatgaagaat




/GEN = HSPC155
caagccactgaggcagggcagagggacctttgataggctacgatactattttcct




/PROD = hypothetical
gtgcatcacacttaactcatctaactgcttccccggacaccctccacctctagtt




protein
gttactaagtagctgcagtaggcattgctggggaagaaacaaacacacaccaaac





agtactgctacttagtttctaaggctgcacagggaagggaaagactgggctttgg





acaatctagaggtaatttatatccgcccccaggtggagcaacatgcgattctgga





ggcacgggagtaactgaaagtgagtacatatagtctttctggtttc





217895_at
Human
/DEF = Homosapiens
catagctgctggaatcacacctgagaactgagatataccaatatttaacattgtt


(SEQ. ID. No.

hypothetical protein 
acaaagaagaaaagatacagatttggtgaatttgttactgtgaggtacagtcagt


28)

FLJ20758 (FLJ20758),
acacagctgacttatgtagatttaagctgctaatatgctacttaaccatctatta




mRNA.
atgcaccattaaaggcttagcatttaagtagcaacattgcggttttcagacacat




/GEN = FLJ20758
ggtgaggtccatggctcttgtcatcaggataagcctgcacacctagagtgtcggt




/PROD = hypothetical
gagctgacctcacgatgctgtcctcgtgcgattgccctctcctgctgctggactt




protein FLJ20758
ctgcctttgttggcctgatgtgctgctgtgatgctggtccttcatcttaggtgtt





catgcagttctaacacagttggggttgggtcaatagtttcccaatttcagg





218625_at
Human
/DEF = Homosapiens
attcaagagagatgtccacggccgaaacatacggtgaataattcacgctcacgtc


(SEQ. ID. No.

neuritin (LOC51299), 
gttcttccacagtatcttgttttgatcatttccactgcacatttctcctcaagaa


29)

mRNA.
aagcgaaaggacagactgttggctttgtgtttggaggataggagggagagaggga




/GEN = LOC51299
aggggctgaggaaatctctggggtaagagtaaaggcttccagaagacatgctgct





atggtcactgaggggttagctttatctgctgttgttgatgcatccgtccaagttc





actgcctttattttccctcctccctcttgttttagctgttacac





218768_at
Human
/DEF = Homo sapiens
ttggatgccctaactgctgatgtgaaggagaaaatgtataacgtcttgttgtttg


(SEQ. ID. No.

nuclear pore complex 
ttgatggagggtggatggtggatgttagagaggatgccaaagaagaccatgaaag


30)

protein (NUP107), 
aacacatcaaatggtcttactgagaaagctttgtctgccaatgttgtgttttctg




mRNA.
cttcatacgatattgcacagtactggtcagtatcaggaatgcctacagttagcag




/GEN = NUP107
atatggtatcctctgagcgccacaaactgtacctggtattttctaaggaagagct




/PROD = nuclear pore 
aaggaagttgctgcagaagctcagagagtcctctctaatgctcctagaccaggga




complex protein
cttgacccattagggtatgaaattcagttatagtttaatctttgtaatctcacta





attttcatgataaatgaagtttttaataaaatatacttgttattagtaatttttt





cttttgcattaccatgtaaaatttagacatttgaattttgtacttttcagaatat





tatcgtgacactttcaacatgtagggatatcagcgtttctctgtgtgct





218818_at
Human
/DEF = Homosapiens
ttttctaaaccacctctgggactcagctccccccgccaaaaaaaatgggtctcct


(SEQ. ID. No.

four and a half LIM
tctgggctccaggattgtctccccactccagcatccccaaactggtactccctga


31)

domains 3 (FHL3), 
cccaggcccccaatcctgggctcttacagagcatccatgagtcaagccccctccc




mRNA.
cacacctggactccagaattcaccctctcccctgcagtctgggttcccagactga




/GEN = FHL3
gtcctctccccaaatcagggctctagacccgagccctccaaacctggactctggg




/PROD = four and
acttaggcccccttaaatctagacttctctttataggtttcaggtctcctatggg




a half LIM
tgcctgggaagtccttgaaagtggactgttctcaggcttgacctgccccacccca




domains 3
tccccgcggttgaggctgtgggggcagcagatcaggagcccactgataaggggcc





ctagggtacagggtgctgcccagcaggtcgccaccgagtgtcttctcattttatt





tcagctccattttgnccatagatgggcagaggggtgagattggctcatccccc





218998_at
Human
/DEF = Homo sapiens
cagtcttctataatgtgcctaccaaaaagcctagtcctagcccatctgcctcaac


(SEQ. ID. No.

hypothetical protein 
tcctctcccttttaggttgtagggaagaggccggagtgtagagtatattatatct


32)

FLJ20457 (FLJ20457), 
tctgtcccccttatgccaacaagatggccttcccctctgaaacaaagtaaaactg




mRNA.
caacactgtgacttcttaaatgagggatatgtgaaaaggctatgaaaaatacaaa




/GEN = FLJ20457
ggctttcctaggaaatgtgttataatgcagcgggaagctaattcttgaaatatgc




/PROD = hypothetical
acattatagttactcagtctcacatactctagttactggcaaagaagttactgag




protein FLJ20457
aatatgtcattcaaaggcataggggcctttgaatggaacaaatgctttcacatca





tttaaagtaaaaaaaaacctccaacaactgtgaatttat





219595_at
Human
/DEF = Homo sapiens
ataatatcccccagtattttccatattaaatgctaattatcttttgatttctttt


(SEQ. ID. No.

zinc finger protein
tcataagcagatctggcatttattacagggctgccgcttaagagaactcattata


33)

26 (KOX 20) (ZNF26), 
atgaacgtttattatattttgcagttccatgcctgttgtccattgattgacatga




mRNA.
gcacccctgttttctctggagaaatacctcccctctctggggtgcttcctgtggt




/GEN = ZNF26
agtgtctttcaggtatccgttccactagctacaggtgagcattttacccattgtt




/PROD = hypothetical
ggataatggtaatctctttttcagaattttgagtctgtaattcatttgtacatga




protein FLJ20755
accagaaaatgtgggaactcattcattcttgtcccagaattctgttgagaacatc





cattcattctggctaattgattacaagaataactgtggatacgatccctttagaa





cctgcttctctgatctgt





219906_at
Human
/DEF = Homosapiens
ggatcagctcaagaccatgggttggagaattaatgttcacacttctatttggaga


(SEQ. ID. No.

hypothetical protein 
ctttgaatcccctctacacaagctacgcaagtcaagttagttgccaagaaagcac


34)

FLJ10213 (FLJ10213), 
agatgacaacctattaatgctgtgagaatgtttctagatcagtgcatggatggct




mRNA.
ccattgctctacgggccattgtgtctgagatcccagtctttgaggagaaaaaaaa




/GEN = FLJ10213
caatggttaaaaaggcattggggaaatattttgagtttgggggtgtactttgcca




/PROD = hypothetical
ccccattattggggagctgtcaccacgaatgttcccaaacttagcaacagcggca




protein FLJ10213
aactactgggccaagatgagcaaccccacatttttgggatttaaagctcctgatg





ttataccaggatcaaccatcacactccctttgcttcaaatggcgtctaccccgta





agatcttgaggg





221214_s_at
Human
/DEF = Homosapiens
caggaaggaagggcgcagcgtcccctccttcagaggaggctctgggtggggcctg


(SEQ. ID. No.

DKFZP586J1624 protein
ctccccatccccccaagcccacccagcactctcattgctgctgttgagttcagct


35)

(DKFZP586J1624),
tttaccagcctcagtgtggaggctccatcccagcacacaggcctggggcttggca




mRNA.
ggggcccagctggggctgggccctgggttttgagaaactcgctggcaccacagtg




/GEN = DKFZP586J1624
ggcccctggacccggccgcgcagctggtggactgtaggggctcctgactgggcac




/PROD = DKFZP586J1624
aggagctcccagcttttgtccacggccagcaggatgggctgtcgtgtatatagct




protein
ggggcgaggg





221249_s_at
Human
/DEF = Homosapiens
gagaagacgccacagatttccttccctctcctccaggagaccataagatagatcc


(SEQ. ID. No.

CEBP-induced protein
cccatcctctcagccctattcccatgcctccctctcattggaggagctgaccaaa


36)

(LOC81558), mRNA.
gcagccctaacgggccataacacttgaccaattcagctgctggcagagggaggaa




/GEN = LOC81558
acaagtgttttcccaagtggcattttcatctcgctttcaccctgactaaagattg




/PROD = CEBP-
tcttaagtagcagcccagcccgcccagccccaggtgggtagtggggaggagagct




induced protein
ggcattcctccaggtggcaaatggcgactctatactctccgcccgccccagggct





ggatggattagaaaaatccctatttttcttgtatcgatgtagagactctattttc





tcccaaagacactatttttgcagctgtttgaagtttgtatattttccgtactgca





gagcttacacaaaattgaagaatgttaatgttcgagttttcttatcttgtgttt





222587_s_at
Human
/DB XREF = 602127301F1
gacatttgggatttacttttctccaatacctgccaatacagaaaactattatcag


(SEQ. ID. No.

/CLONE = IMAGE:
ttgttattgttatcccttgaaaagcgagggtgacaaaaacaacaaaacaccgtta


37)

4284168
taaacacatcaaaggttcattctgactgaggtaagactttccaagcccttgttag





attaggccttataaaacttgtgtgcattataacctaagctgtgcaacctggtgaa





gccaagagtgaactgatgtttcatttatattttcatccaaatgacattatctgca





cgtttttaaaatttaaaaacaaaggactatttaaaaatacagtttattaacaaac





gtgaaactactttctgttacattaggtgttccctagtgtttcttaatttct





222612_at
Human
/DB_XREF = yw86h04.s1
cagaatagccaagaaatccctccttttcaacgctctgtgcctggnaaccattaga


(SEQ. ID. No.

/CLONE = IMAGE:
ggagntttaaaaaccatccctcatagcccacaattttgggtcaactctcaaaatt


38)

259159
gggaataagaaaactggcactgttgggagaaaaatcgttcttactgaaacatgaa





ctggctcaggcaagcaaatagcgggagtcggcacaggaaggagtgtgtgctgcgg





ggatgcgtggtggcgtcaccttcaaaactaaagtggtgccaggcggacagatgag





tccttgatcttgtttcctgatcttgtttccatttgactgaattctgaaccttcat





tgtcttcacagtcttgccacttgcctagtgaggcttttccgaacctggaaggaga





cgtctagaaatcccaactttgctgtgtaaggaccattagctgcaagtcagtggaa





gtctatagaaagcagtgtgaattccatagtggtcttgacttct





222775_s_at
Human
/DEF = Homosapiens
ttgatggattttcatttcttcgcacttctgagacggcaaagccaaccacttagaa


(SEQ. ID. No.

cDNA: FLJ22567 fis,
gccttccacatctttgtcacctgcctggctcctgctctctgatgtacctctgggt


39)

clone HSI02118.
agtgagatggaaatggtgcctgcagaagttggggagaaggatacttttgcacagc





ctccatgatgtctttattgcaaatatggatgacaagggtctctgttacaggggcc





tcagagcaccttcgtttctcctctagaccagggacaggtgtagagataaggactg





gcaaccagagcctcagcatccaaagatggactgaagtgggatggctgacaggcac





atnacttacgggaaagggaatttcatacatacgatttttgttttgtgggtaggag





ggcttatcatcaacactg





222807_at
Human
/DB_XREF = 7b44a06.x1
taagatgcgctgatctctggtggttgtcactagttctnctaggtgataatgattt


(SEQ. ID. No.

/CLONE = IMAGE: 
acccatagatggagctgttggatattattttattgtacaaattcatgtttaaaaa


40)

3231058
actttgtgactgtttctagttaagtaattttttaacctttcttgggtcatagact





tctttggtaaactatgaactctcaccaaaaagatacacatgcaacatgttaaata





catgttagactttgcatacaattttaggggctcatgggcctctaagcctatccat





gtattccaggttaagccctctgttatgatcaatccatt





222906_at
Human
/DEF = Homosapiens
gagtcatcacactgttggaatagtctgctctttnacatgctcaggtagggaaaat


(SEQ. ID. No.

cDNA FLJ10557 fis,
aggaccaaatatatttccanagtgcctaccactgtgtcatgtttacagtgagagt


41)

clone NT2RP2002537.
ttaaatattgttgatgtcctgactctgtgagctcatagggagtatcttcatagta





atgacatttgatcagccataaaatttacattatgttcatatgcacccaaaaaagc





tagtcaggtaatgaatacccttgaagtgaatagcaattttgatttaggcagtgtg





ttaggccatccttg





223175_s_at
Human
/DEF = Homosapiens, 
tgttctttcagctgctccaaggattgagacccaagtcatcatgaaaaaggcccaa


(SEQ. ID. No.

Similar to 
gtacagtcttaatgcgataaatccactagctaagacgtcgagtgccaagaccagc


42)

feminization 1 a 
cttccagccgaggtttggacaaagtctcaggttcccgtgactcagggtaaggtgc




homolog (C.elegans),
tggggctgccagaggacctgccccagcaagatttttgtcaagagcgagactccat




clone MGC: 4216,
cagcccaggcagacgggagcaggttcttggccagcgtagacagcagcaaacagca




mRNA, complete cds.
gcagggaagccattctcactgcatcctccctgcagtagccacggccaggccctta




/PROD = Similar
ggaggagcagtgaccgggggtgtccagaaatatcctgtccctggatggaaactag




to feminization 1 a 
gtctcgtttggattttttttttttttttttttgccgtgttaggaaattatttatt




homolog (C.elegans)
aatttacaagacaggttttaactcagccgaggtgggaaatggtgtccctgtccct





cccaaagcacagagcacagaaatgaggccgtttacatggcgagtctccgtgctgg





tgtttaagtc





223197_s_at
Human
/DB_XREF = wf38a09.x1
tgttcattttccaactgcactaattgtgcatattactctgcctaatcttgtgcat


(SEQ. ID. No.

/CLONE = IMAGE:
gttttcattgatttccctctcccggcttttgcttctcttgaaactgttgcccagt


43)

2357848
cacttctgctccaattctcttcctctctaaatagtagtttaattactgccacatc





tccatgcatcagcaaaatgttggtgacatttttctagcctggcagaacagattac





ttaaagctatttcanttcaaagcagactgaatgtgacttcatctaaaggcagcat





taggtactgcatggaaataggtcattaacttgaaactcttatcaaaatatatttt





accagtttccagaatttccagtacaggaccgcctgaagagagagccattgttcaa





ttccaattcagtgtgagtgacaaagtgaaatttagaagtgaagttgtctatttga





tatttaactctttattaaatctttctttaaatttctgcctgtcagtctatattgc





tgtttttattatacatcagtttctttgtataacttgtgagttcccatgtgttttg





t





223206_s_at
Human
/DEF = Homo sapiens, 
atttccgggacattggcgttcccatgaccagtgtgcggctgccctgctattttga


(SEQ. ID. No.

HSCARG protein, clone
gaacctcctctcccacttcttgccccagaaagccccagacggaaagagctacttg


44)

MGC: 11351, mRNA,
ctgagcttgcccacaggtgacgttcccatggatggcatgtccgtgtctgacctgg




complete cds.
gtcctgtggtgctcagccttttgaagatgccagaaaaatacgtcggccagaacat




/PROD = HSCARG
cgggctgagcacttgcaggcacacggccgaggagtacgctgccctgctcaccaag




protein
cacacccgcaaggtcgtgcacgatgccaagatgactcctga





223448_x_at
Human
/DEF = Homosapiens
tttgcccagtttgagccagattccacagagtatatcaaggttcatcacaagacct


(SEQ. ID. No.

brain my045 protein
atgaagatatagataaacgtggaaaatatgaccttttacgttcaacaagatactt


45)

mRNA, complete cds.
tggtggaatggtgtggtattttgtaaataataaaaagattgatggtttgctgatt




/PROD = brain
gaccagattcagagagatttaatcgatgatgcaaccaacttggtccagctgtatc




my045 protein
acgtgctccatccagatggccagtcggctcaaggggccaaggatcaggctgctga





gggaataaatttaatcaaggtctttgcaaaaacagaagcacagaagggagcctat





atagaactaacactgcagacttatcaagaagcactcagtcgccattctgcagctt





cctaaaaatattttaaaaatacatttattttactaaatactgactacatttctct





gttaatattgagctaaatgttaaaaaatggccagattaaaagatatcaatttgta





gttctccctacaaagcaaaaattattaccctactcacttttcgtaggctacaagg





atatttgagtgcctggtta





223470_at
Human
/DEF = Homosapiens
ttttaacaaagtctgcacctcccagtactttctttggtacctctgcttactgcct


(SEQ. ID. No.

PIG-M mRNA for
cttgtgatgccactagtcagaatgccttggaaaagagctgtagttctcctaatgt


46)

mannosyltransferase,
tatggtttatagggcaggccatgtggctggctcctgcctatgttctagagtttca




complete cds.
aggaaagaacacctttctgtttatttggttagctggtttgttctttcttcttatc




/GEN = PIG-M
aattgttccatcctgattcaaattatttcccattacaaagaagaacccctgacag




/PROD =
agagaatcaaatatgactagtgtatgttccacaccctctgctactgtgttacatt




mannosyltransferase
ctgattgtcttgtatggaccagaagagagctttgggacattttttctgaacattc





taagcattctagtgaaagttcccatgttccaacagaacttaaaagcaatgtttgc





cttatatataaaaggtacacaataattgaggtccaccttctaggaaatcctagga





ctcgtttatttgggacatggt





223518_at
Human
/DEF = Homosapiens
ttttgttcacctctgcagactgtgaatcctagctgccagtttgcctattatatgc


(SEQ. ID. No.

DNA fragmentation
caaggcatttgcaaaaatctcattaatctaaatcaaaatagctttaaagaaaaat


47)

factor DFF35 (DFF35)
gcatacacttcctcagatcatcaaacagactctggtccaaggttggtaatgaaat




mRNA, complete cds.
gactgttcctgacagggaggaatagcagggcccaatcttctgagatggcttctgg




/GEN = DFF35
gtctttccatggtcagagaagatctatagtccgtcctgaggtctgtcaatgtcac




/PROD = DNA
aggaaaaggcaaacttgaggggatcgtcgcctgctggctaagaccagggagctaa




fragmentation
aaacttgaggaagggaacctgcctgggtgggtgctacttctgattcattgtcctt




factor DFF35
gtccctgtcataagtacctccctattgtagatagaagggaaggaaactgttgact





tgagcttggcta





223528_s_at
Human
/DEF = Homosapiens
ggagaatggaacaaaagctgggcacagccttctcatggatgccagggatctggtc


(SEQ. ID. No.

false p73 target
cttaagggaaaagggaagtcacctttggaccctcgacctggttttgtctttgccc


48)

protein mRNA,
cgtgtccccatgaactcccttgtccccagttgaccaacctggcctgtagcttctc




complete cds.
acaggcgtaccatcccatccccttcagctggaacaagaaaccaaaggaagaaaag




/PROD = false p73 
ttctctatggtgatccttgctcgggggtctccagaggaggctcatcgctggcccc




target protein
gtatcactcagcctgtccttaaacggcctcgccatgtgcattgtcacttgtgctg





tccagatgggcacatgcagcatgctgtgctcacagcccgccggcacggcaggtat





ggggggtgtgaccaaaatcagtgggatgtggcaggaagctgcagcccacgccagc





atctgttcccacagggatttgtatcgttgtgcccgtgtcagctcctggggagatc





ttttacctgtgcttactccgtctgcgtttcctccatctacggctcaggatccctc





tgagagttgatgag





223570_at
Human
/DEF = Homosapiens
ttttgggaggttgttgtgggagatggttgatttaggttttcaaaagctagaaata


(SEQ. ID. No.

mRNA; cDNA 
aaatttacatgccttagatttcataaaattctgctctaattgggtggaaggtgct


49) 

DKFZp434H152
gtatctaacttgtgttcctcctaaggttatgtcctaataactattcttttaggag




(from clone
tatacttctactttatagaaggttgcttttctttttaattttttctaacaaagaa




DKFZp434H152)
aagaataaagtatttattaataagaaccagaaagcacttgaaactgatgttttta




complete cds. 
atggctcatttagggtagatttatttatctcattaacttaaaacagctatgtgta




/GEN = DKFZp434H152
tgaaataggtcacaacagaacttgaacaccaggttggtgtctgagcaatcccttt




/PROD = hypothetical
cttatgggaaaaacaatgttcttgtttgaacagagggtatcattgcagtcagtat




protein
tcacgtgtatattgttatataagttgtataatatgcttgtaaaggctgagggtga





gctgtatctggatgcctttttacaatttgatt





224473_x_at
Human
/DEF = Homosapiens, 
gatggccccaaaggctgagggccccaaagccacttgtctcctaggatccaggcct


(SEQ. ID. No.

clone MGC: 2586, mRNA, 
ctgggcttctgccaagaactcagggtggccctatgacttggaggagcaagatcag


50)

complete cds.
accgctcaaaggtccccgtgttcactgttacccagaggctcttgttactacccac




/PROD = Unknown
ttcattccccaccgctgccagtgccactgccaaccctgttcacaggcgcttccag




(protein for MGC: 
cccactccagccaggggagcagggaagaagaaggggctccctcctcttcacattc




2586)
cccccgaccccaaagccagagaaagccagatggcaccagctgctccggatgtgcc





tgcccacattgggggacagggccgggcctgggctcggttcccaggtttgagctct





gcagcctctctcctggagtgagggggctgaagtcagaccaaaggaagaactcaga





aatgtcttgtttatttgtgtttgtgaccaagcagcctctcccttcacccaggttt





atggcctcgttttcacttgtatattt





224721_at
Human
/DB_XREF = ts83b12.x1
gcagaagaaagtcttcccacaaccccattttatttcatattgggaaaacacaggc


(SEQ. ID. No.

/CLONE = IMAGE:
aacagcaggatgaaaaactaaacgaaactttagagaatgagctggtacaactacc


51)

2237855
cttaacagaaaacatacccgcaattagtgagcttcttcacactccagcccatgtc





ctgccatctgctgctttcctgtgctccatgtttgtaaattcattgctgctgtcta





aagagactaagagtgctaaggaaattcctgaagatgtagatatggaagaagaaaa





agaaagtgaagattcagatgaagaaaatgattttaccgaaaaagtccaggataca





agtaacacaggtttaggagaagacattatacatcagttgtcaaaatctgaagaaa





aagaactgagaaaatttaggaaaatagactacagctggatagctgccctttaagc





cttggagatggggaggatccttggactttgtgtttttga





225025_at
Human
/DEF = Homosapiens,
gaagccatcggctgagactacacagcttggggccccgaggatgaaggcgtgtaac


(SEQ. ID. No.

clone IMAGE: 3687782,
cactgtgcccccagcgcctgggtgcagcatgccgactacagctggtaccaggngg


52)

mRNA, partial cds.
gcagtgccngctcagggcctgttacagtctacccctacatgccctggacacccta




/PROD = Unknown
tttgtgcctctgctggtgggtacaggggtggccctagtcactggtgccactgtcc




(protein for
ttggtaccatcacttgctgcttcatgaagaggcttcgaaaacggtgatcccttac




IMAGE: 3687782
tccccaggtcttgcaggtgtcgactgtcttccggcccagctccaagccctcctct





ggttgcctggacaccctctccctctgtccactcttcctttaatttatttgacctc





ccactacccagaatgggagacgtgcctccccttccccactccttccctcccaagc





ccctccctctggccttctgttcttgatctcttagggatcctatagggaggccatt





tcctgtcct





225097_at
Human
/DB_XREF = 7n04b01.x1
agggcttgaacctgagtctgcccagctccagaactgagcttgcagccattagcca


(SEQ. ID. No.

/CLONE = IMAGE:
cagctgtctcctgcatgtctgagcaaagaaaggcctttacacagcatcaccctgt


53)

3563472
gccatcccatgncaccgtgggactcagctaaaggactgtgcaaagagggggctcc





tgagttggatttaggcaaaaggggcagaattcgttttgatttttagagaaaatct





ctggagagtttcttttgattcatagaattccttttagatttctttccagcatacc





aactagctttagtagtgctacaaccagctcttataagtaagagtgaaaaagtatt





cttttcttctttaaaaaataagtttttcttgcttatagttaattctagaaaggca





atactaaaggtatatattttttcaaaatgctatttttactgcacttgataattat





cctgacagctctgatctctgtaatagattcactcttcagctctgggcagaaccag





aggcagggttcacaccaaatttgtaaataccatatgtgggtctggtgtccaggaa





ctttttct





225506_at
Human
/DB_XREF = ng25h11.s1
taactagttagttatcacctchtcccttaaagtcagtgacctgtgtttgatgtat


(SEQ. ID. No.

/CLONE = IMAGE:
attacatagagtcttaagtcagtgtacagttccactggaatttgacagttgtctc


54)

935877
tacagtcatgcaactcgaagtagaaaagagtgctggacataggaagggggtgctt





ggtttgaggggttaatgtgaggccttttgaaaatgaatattttgataaaagaatt





cttgttttagcacagttgatgcacataagtgattctcatatttgttgtataaact





ggtttaatacatttggaacatagttggattacattcatttcctgggaaagctagc





ttaccatacattcaagtttataaaacaatttnccatangcaaagccatttaaaaa





gttcattctgaaaattatttcatttacctacagtgaaataattgtgaactaagta





gtctttctgaaaactgttgggttctaggcattcctg





225554_s_at
Human
/DB_XREF = zl35g07.s1
gtgattgcagcaggggtctctgccccctcgctcccaattcctagtcgtgacttca


(SEQ. ID. No.

/CLONE = IMAGE:
tttctaaaacagagcctgaccaaccttccatgtatctccatcctcccctgctcca


55)

503964
gccagggaggactgagggagtgccccgagacccacgcacatgttggggcttctgg





gccaagagtacttttatataactaatttctaaatccaaaagctcaaggaatagac





agtgttctgtgacatggattggtttgaaggagttacccaccatcccagcacgata





atgtcatctcccaagttggatggcagcacgatctggccctagggagcttcctgtt





cccagaagtcattgtcctgggctatccagatgtccctagtaaatcttgcttcctt





ctgcaatgttagtaatgccttaagctgacagttgctatttgcagaacagttttcc





tctttgcttagctagtaacttgcctctgagcctgggctgatctgagaaacaggtg





tgacaagagcatgaaccagaggtgcacctggggcagttccctaataaa





225584_at
Human
/DB_XREF = qp96b11.x1
gtgctgaattgtcactcatgggcttgagagtaggagactggagaccaaggtggct


(SEQ. ID. No.

/CLONE = IMAGE:
agaatccagttgggcctgatgctccctgttgaaagggctccttgtggaatgaata


56)

1930845
gcacatggctcctgtggtggatctgatagtggcatagcaccaagtgcaggcctgc





caaggggccacagacacagaagatgctcccggggtcccccatgtactccagacac





actgcaggccacctctcccagcaggttgccagtcatgggccccatcatcatgact





tctgtccaaggtactgtgtgcagaatgtgattgagattcaagtcagggcctctct





gcccttttccctccagaaacaaaaccaagataatttatcctgaacacaggtgaaa





aaaggaagggagggaggagaaaaagtccgggtctcacctgggattctctgtctcc





tgcaacatgaaggatttagcctgggaggaggtggtgagaactctgggagagaaaa





agaaggaaagaatagttttacccatgctgaagtt





225841_at
Human
/DB_XREF = hy16b02.x1
gacattggtggctcaaaggcccctgtcccatgctttggaccagtcttcacagagg


(SEQ. ID. No.

/CLONE = IMAGE:
ttgagaaggccaagatagagaactctcccacacccttctgtgttggagataaatt


57)

3197451
tttcgtacctctgcagagactccttgcgtatcccaagttgaaccgcttatgtgct





aatgaagagatgatgagatcagtcattgctgactcaattcctctgagcagtgatg





gttctgcagtggtggctgacctgcgtaattattttgatgaacagtttgagttttg





aaccatgtttatttcctgaaatttcagggtctcagcgatagttgtgctcacttag





aatttagttttttttgtgtaatcctaattcaagtaatgtttttaaagtttcactg





caaaagtctatgttccaagccattggacagacctgcttgagatatggcc





225947_at
Human
/DB_XREF = ot61d03.s1
accttcaccctacagcattacaggctttaatcagattctgctggaaagacacagg


(SEQ. ID. No.

/CLONE = IMAGE:
ctgatccacgtgacctcttctgccttcactgggctggggtgatccttggtgcctt


58)

1621253
tgtttccacaaggccttttcctgccccctgccttgccaaagacatttaatcagca





cacagctgccagactattcccacagtgctccaaatgcacatgaacaacagtgacg





gctccagccttcgacccagagccccgtgcccagtgcgtcagtgggcctggggttc





caggctacatcaagcactgatggtgtcagggctggtagttaccaaatcagggtta





agaaacatcagggccacatttcactaccttcacagatcaaactcagcagcagtca





tgactgtctgtcactacactggggatcccaattccacataagcacttttggaaga





aaacagccaaagttggcctaaaattggcgctggaatttgggctgggaa





226124_at
Human
/DB_XREF = nx88c07.s1
ggtgcaccatgattagctcacacacaatgccaaggctgtgcttctattatctgat


(SEQ. ID. No.

/CLONE = IMAGE:
acatagtttgacaatgggtaattctactcagaccctccctactgattggctagga


59)

1269324
tgcctgtcaggaactcattatgctactggttgtttggggatccccatagtggact





actttcaggaatggcatgaattgtaaccaactgagtgctgcccccactgttacgg





aagtttataaaaccttagttccagaagacccaaaggagagtactggtttgtgttt





ggtgcttggcctagatccagccaccactctgaaactcancacatcttcattgaca





gggagggagcccaggacatatgtgtggctcattgaccagaaggctttcttagtcc





caacagccatgaaccatgcacttatggatacccagcctttta





226139_at
Human
/DB_XREF = 7e37b01.x1
gcttgcacagaccagcagtcacagaaatcattcttcctgctgtactgggccttaa


(SEQ. ID. No.

/CLONE = IMAGE:
ctgcctgcaaatgtccagcactactgcataggatgccagagccaccgaaggaaaa


60)

3284617
cacagccaagtttaataataataaaaggaaaaatctcagcctgcagaactctggt





tttgacccaccatcggccagatgcacatcttcagggcctgttgagcaccttctga





aaagcagggctcgtaatagactccagcacattccatcagagtcaggaaaactgcg





gtgagtcccagagaatctagggtgcagggcagggagcaggagtcataaggagtga





taacctaaactgtgtgtagtcagcggggagggtcttatgttatcaggtgaaatga





gagccagtaagttagttgatcctgtcacagatataaccctgataacaccccatag





atacgcgacacgtgtgtcctgcccctgctttccccatccaacatggttcttctgt





tccacagac





226308_at
Human
/DB_XREF = zn45g12.s1
atgggcagcagctcttagacgccctgcagcatgaactggtgaccactcagcgcct


(SEQ. ID. No.

/CLONE = IMAGE:
cctgggagaacttgatgcttggtgattcggaagaaaatgtgcaggtgtggactta


61)

550438
ctgagcgaactcaaggacgtgacngcgaaaaaggaccttgagctccgaaggagct





ttgcccaggtgctggaactctccgcagaggcaagcaaagaggcagccttggcaaa





ccaggaagtctgggaagagacccagggcatggcgccccccagccggtggtatttc





aatcaagacagtgcctgcagagaatctgggggagcacccaagaacacgcccctgt





ctgaggacgacaacccgggtgcctcgtcagcccccgctcaggccacgttcatcag





cccaagcgaagatttttcttcaagcagccaggcagaagtcccgccctctctctct





cgttcagggagggacttgtcatgactcatggttacattcaggatacttgagcact





ttatatactaccgtagc





226428_at
Human
/DB_XREF = wl62h06.x1
tccagttctttgaagcatcctctgctgggtcttggggtgtgtggatggattggct


(SEQ. ID. No.

/CLONE = IMAGE:
gtctgatgggattggtaacccctcgctactcaagatggggggatacaaacacctt


62)

2429531
cagggaaggggagcctggttcttctcgttttccttttttttttttttttnnnaaa





aaaaaactatttaattttttaatttatttttggttgttttttgcacaatgaagtt





tcagcttctcaaccttctcccctacccagggctgtggacccagactggccttgag





ccacagtccctctttccctcctcaccctcttccccctgcgggctcccgggtctgt





ccatttgttactgtgctgtgctggggattggcg





226616_s_at
Human
/DEF = Homosapiens
gtgtttgctgcggcaaggacgagccggggcgctgaagactatgctccaggaagcc


(SEQ. ID. No.

NADH dehydrogenase
caggtgtttcgaggacttgcttctacggtttctttgtctgcggaatcagggaaga


63)

(ubiquinone)
gtgaaaagggtcagccacagaattccaagaagcaaagtccaccaaaaaagccagc




flavoprotein 3 
cccagtgcctgctgagccgtttgacaacactacctacaagaacctgcagcatcat




(10 kD) (NDUFV3),
gactacagcacgtacaccttcttagacctcaacctcgaactctcaaaattcagga




mRNA.
tgcctcagccctcctcaggccgggagtcacctcgacactgagggccctcggtgtg




/GEN = NDUFV3
aagatgaaccttccaccgtcttc




/PROD = NADH





dehydrogenase





(ubiquinone)





flavoprotein 3(10kD)






226651_at
Human
/DB_XREF = wx26b03.x1
ttaatactttcctactgataatgaaatttaaaantggaaantttgtgagtgtttt


(SEQ. ID. No.

/CLONE = IMAGE:
tcttgtccaatagagcctaattgtttccttttttagtgatttaacaatctcttga


64)

2544749
gggctgcacctttaaattcccagattgtcaatagacatgtacagtatatgggata





aggtggacacaagtgcacatataaataaaatcttcttaagacttttaactattca





tttacagtaggagagtatgtagaaatcatcatccacaagtcataattaggttgtg





tgcctactgtagttttttccatttctgtattatataaacatttgcatattaaaat





ttgatttttcccagagacaagtattatatactgtatctatatttaaatcaaactg





tggtaatatatttctcagaaaataatgttggggactatagcctgaacatgtggac





ttgaagcgacatggaggaggaggttgatcccattgtgtataag





226693_at
Human
/DB_XREF = xj03e02.x1
gatgtcttttttggcagtgcacagccagagaacaacacatcacacacaagaaaca


(SEQ. ID. No.

/CLONE = IMAGE:
gttgtgctcatgtgatgggggcctcagcactaggaaggagtggactgttggcgca


65)

2656154
cgcagcagcttgaataaatctgaaagtcactacgctgcgtaagagaagccaaata





aagcgcatgctgtgtacagagggtgtcgagaatgcctcctacgtgacggaaagca





gatccgtggttccctgcagactggcaggagcagattccaaaggcacaggaagaag





cttgcaggtagaatgtgttcattaccttctgcgcattataccacaa





226749_at
Human
/DB XREF = AL582429
gaattgattaccagctttacttcccgatcacacaggacagagaacagctgatgtt


(SEQ. ID. No.

/CLONE = CS0DL001YO17
ccctttccactttgttgaccggctgggaaagcacgacgtgacctgcacagtctca


66)

(3 prime)
gggggcgggaggtcngcgcaggctggagcaatacgactggcaatggcaaaagcct





tgtgcagctttgtcaccgaggacgaggtcgagtggatgagacaagctggactact





tactactgatccacgtgtgagggaacggaagaagccaggccaagagggagcccgc





agaaagtttacgtggaagaaacgctaagggtttgctcccaggaaaggagaggaag





agctatatatatgtgccgacatgtggcagacacacagtaaataatggctgaccag





catgagggcagtact





226810_at
Human
/DB_XREF = 7a33c06.x1
ggctttaagttgtttcctatgtaaggtaatctttcttttttagtattatctaaga


(SEQ. ID. No.

/CLONE = IMAGE:
aggatggtagattatgtcattttggaaactattgtgtcccttgtattttaaatat


67)

3220522
ttcaggaaaatgcctacgattgttacaaagatgtgtgttttacttataacataag





ctctgattctccagtggccactgggccttctctgtgctctgtattcaactgcagt





atgaattacagaatgctgtgcatgttcgttagtaccaataccatgtgtatgtggt





agaagttgtaaccagtttctggatctgtatggtactataaaatacttattttata





attctgtaaccgtatggcagtgttatgccaaaaatgtataaagagcaatagtttt





tgttgcttactgctgtattttaaaatattgtttctaaaataatagagttagagtt





ccttttgagtaattatttttaagaactattgccaaatatacatcctgtaaaacta





ataaaagccactccatcttagataaca





226839_at
Human
/DB_XREF = yx78b03.s1
ttttttggccgtgtggtcatctaccacctgcgggtgcttggggagaaggtgtgag


(SEQ. ID. No.

/CLONE = IMAGE:
acctctaggggctgtctcctccaggaagccctccgggaagcacagcaaagtccct


68)

267821
cattctgcacagaaggtttattggttcctcttgggaagggtcccctcccaccacc





tgtccagaagctgcctttgaagtcagttctgggtttccccagctctggctgacca





ttttgttccctgagtgtctgagtccccggcaggcggccttcactcagggtcagcg





ggcaccaggttgctctggaagagcttgaggatgtggttctcgatcacctgttgca





ctgagatggggcagggaaaaggtgggctgtgagcttgaatcgggagtggggtgga





ggcacaggccaacctgcgctctncccttaggggacaaacagggacccttgcagag





acctgcattacagagcaaagctgggagaaccgaggactcaccc





226917_s_at
Human
/DB_XREF = no87g06.s1
ggaagaagtgttgtcggagtcagaggcagagaaccaacaagctggtgctgccgct


(SEQ. ID. No.

/CLONE = IMAGE:
ttagctccagagatagtcattaaagtggaaaaacttgaccctgagctagactcct


69)

1113850
aatctagcttgccattattgtgtgtgtaattatggccaaaaggacataggagatg





gactaagatgtcttggaccacctttgtgt





227181_at
Human
/DB_XREF = qr33c07.x1
atggagaagcacacatggctcccctgtttgaaaaagggcctgaataatactctgc


(SEQ. ID. No.

/CLONE = IMAGE:
ttctgcctcatgacatcagatgctactgttttggtttttttctttgagccccaat


70)

1942668
tcaccatttcaggatgtggatgggggcggggttgggggtaaaaacagctataaaa





agcaactgcagatgctgactgactgcagtgggcagggtatgtagctgctccaaga





tgacttgcatcataccccaattactgctggcatcttagttgagagtataatctgc





ttggttgcctttttatgggaataaagagaataaaaggtattttaatagaataaag





aaaaatttgaaaatataatggaaggtatttaaagagccacccacatagcttcacc





aacccttctcacacatcaactcataaat





227412_at
Human
/DB_XREF = zq40h02.s1
agaaagaggtctctacacaagcccgtgattcttcatggcaagggataacatcaga


(SEQ. ID. No.

/CLONE = IMAGE:
aatgtttcattttctgctattagtttccattcctttccccatccaggcataaaga


71)

632211
gaaacaaaagacaatgatggtattctctgtgtcctcagctttggcacttttgttg





atgttgctaaggagcagtgaccttgctaaaaagactgaataatccacccactgaa





tagctaacctggggaggaaatgaaaatttcctttgtggatctccccaaatccatt





gttgtcaccaggccctcccagaacctcctcagttccttcacagtgcaaccctgtg





tacttggcccgcaacccaatagtat





227427_at
Human
/DB_XREF = wd34g06.x1
ctgctgctgtcacccaaaggggaggtggccagagccctcttgccactggataaac


(SEQ. ID. No.

/CLONE = IMAGE:
aggcccttggtgacatcccccaggctccccatgactctcctccagtctctccaac


72)

2330074
tccaaaaacccctccctgccaagccagacttgccaagctggatgaagatgagctg





taactggtgaaaaccatgggggtggtgctgactcagccgcctattccccaaggag





cttcagggcagtccttctggcactgctccagaattcctccttcttggtgtgtctg





gagggtgggcaaggctgggagggatatcaacttggaggagaacacctagacccaa





ggacttttttctgcccaaggaacacagtttccttcagctcccatccctatgcatg





catcatggtccccccaaaaggaggatatgtgggtgggtgggagggctggggcagg





ggccagatagaaattatt





227472_at
Human
/DEF = Homosapiens
gctccccagacgatgttccaggaggcgggtgtgccagaaggggccacgtcttgca


(SEQ. ID. No.

mRNA for KIAA1623
aaccaccgcgctgtcctctttgagaaggagtcttactcaggactggggcctgtgc


73)

protein, partial
acacattgtcgcctcttttcagcacttagagattccttcctttgtctagtngctg




cds.
aagccagggctgaagttggcctccaaatctgggccgtctcagagngcngcgcagc




/GEN = KIAA1623
ctggagttttccatctgtggccaagacccagtttttgggaggaggccctcatggg




/PROD = KIAA162
tcaagccagcctgtaccaggatggggggagggggttcccaacntangccccagcc




3 protein
acccagactcccccacccccactcccttttccactgctctgacctcgggcactgt





tgaaatatagtttttattgcatttctgccgttttacaaaa





227603_at
Human
/DB_XREF = zb80d11.s1
gcaccacccagcttgggtatctggtgaattctgtggtctgcatgtccatgttttt


(SEQ. ID. No.

/CLONE = IMAGE:
gacattctgggaagggtgngcccaggctgtgatttgccatctactgctgcaggct


74)

309909
atggatggtattcagaagggaggggagatgctgtgtgcgtgttctgaagggtttc





ccactaaatggagagactgactctctccataagtatttgatttttactttatctc





ctcgttgacttcacagtgtaagtgcagtttgtctctactgggtgatgcatgcaga





taaatgtttatgtgaacataagaagtctgcatgtgtgggtgaactctccacatca





tgtcatttattgtccatcattacgtatctgtggtgtctagcacattcctctacct





tattttctgtcattgtacctacttctacctgaacacgtatt





227810_at
Human
/DB_XREF = xd99f12.x1
ggtattctgcagtgactatgggaaagccttgaatgttctatcggtttttaaggga


(SEQ. ID. No.

/CLONE = IMAGE:
cttgagaattaattctggagagaatgccccattgaacatcatcaatattggagag


75)

2605775
ctttctgtttttctacatttgttaggaaacttgtgagcattcacactacagagaa





acttgaaatataaagaagaagagaaagccttcagtgatgcctctgtgttagggaa





aatatggaacttctccctggatgcaaaacctatgagtatattaatattggaaaat





ttttcagtgattcttctctttcttgtatatgagagaacttanatggagaaacccc





taggaatgtaatcagtgttaggatgcctcagcctgaactcttcactgagtggcca





caattttcactgggaacaaaaagtataatcactgttttgagtgtgggatatcctt





tatcagtgtctcatctgtagattggactgctggctcattaatttttttagtcttt





ttttcttttaatataaacatttgtgtatagctgttccctaa





227921_at
Human
/DB_XREF = we90c08.x1
agctttcctttttgactgtcttattttacttaacagaatgttttgaanatttgtc


(SEQ. ID. No.

/CLONE = IMAGE:
cttattgtagtacttttcaagatttccttatttttaaggctgaatgctatcccag


76)

2348366
tgattgtacgtgccctgtttgctgaatctactcatccttaagggtacatttgctt





ccaggtaacatgtttgtgagtaatactacaatgtgcatatatctattccatgttc





tgctttgtctgtttgggatatttttcatacactgattcagtaccatgtgtattcc





cttgcttttgttgtctcatccgttgatgntacgtcccccaaattattgccacgac





cagttgtnatgaagcttcacccttctgtattgtgctaggaattttacagctatag





gttttacattatagtcttcattcatttttta





228286_at
Human
/DEF = Homosapiens
gaaatgggcaaaatagctcaacaggnttttntgcaaagaagaaatacaaatgncc


(SEQ. ID. No.

cDNA: FLJ21836 fis,
aagangcacatttaaaaatttncagnnctattnactcatcaggaaaatgcaaatc


77)

clone HEP01654.
aaaaccncaagacacccaatgtctacaatcaaaaagataatanctagtattgatg





aggatgtggagaaattgaaattctcataacatgctggtaggaatgtaaaatgggg





cagccactttggaaaaagtctggtagttcttcaaatggttaaatgtagagttacg





atatgatccagcaattcctctcccaggtatatacccaagataaatgaaaacttat





atccacataaaaacctgtgcacaaatgtccatagcagcgttattcataatagcct





aaaagtggaaacaatcccagttccagaatgaggaaggggagaaactaatgtgtat





tagctattgtgtgctaagcattcaactagattatttacaaaccttgtatcatctc





aactctttaaagactgtattgcaatgttttgaa





228650_at
Human
/DB_XREF = wf38b04.x1
agggcattaatccccttcatgagggatattctctcatgacttaatcacctgccaa


(SEQ. ID. No.

/CLONE = IMAGE:
agaccccacctcttaatactacatcagtgatgggttcaatgtatcaattgggtgg


78)

2357839
gagggggcacattcagaccatagcatctagtcattctggttttattaagatttat





tagacctgaggcatgaaaaatagcatactggatgggacttcagcatcgatgagtt





gccttagtaatactgtt





228736_at
Human
/DB_XREF = xa46a03.x1 
ataccttgctcaaagagaccaacatttggactgtatctgaaaaantnaanangcc


(SEQ. ID. No.

/CLONE = IMAGE:
ncgaggnatanatncaaantnttctcacnggaacngccncattcncatrtttgng


79)

2569804
ntgnnacatttctgnnaggagcttgaggagttttgggtttacagagcccttttgg





tagaacttaccaagaagctgacttactgtgtaaaggcagaattaatccctctcat





ggaagttactggagttttagagggtcgagcaaaacagttatacagtgcaggttac





aaaagtctaatgcacttagctaatgcaaatcctgaagtgctcgtaaggacaattg





atcatttatcaagacgccaagccaagcaaattgtttcatcagcaaagatgctgtt





gcatgaaaaagcagaagccctgcaagaagaggtagaagagttactaagattgcct





tctgatttccct





228930_at
Human
/DB_XREF = tu75d08.x1
gacttgtaagggtgccttaaatcctgaantactngtactnctngtattnactaaa


(SEQ. ID. No.

/CLONE = IMAGE:
cccnatgttagtttnacgccnaagattcntgtggtggtttnacatattctttttc


80)

2256879
ccctttgttaaggtggggaggccacagcttatgtgaatgactttctcaggagtta





taaagtgatacaggtaaagctaagaaaagaacagattttgataacttttgtttta





actgtccagtgttagggattgtggctacagtggtctaatttttaaaaactctttt





ttttgctttgttttttaacagacttatcagcaggttgcaggtgaacatggccttg





aggtaaatctgtcccttgctgaatacagtttcagtagattgtttatagtagtttc





aggaattgagattttttacaaaaatacaaaagttttgcttggttctgttctagat





gttttcttctaaataaatgagaaagatgtttcaacaaaggctctttatgctgaat





aattgtgatgcttgaagttgctaatctgctt





229001_at
Human
/DB_XREF =
gtctccgaagaggaagtccctgactagctatataactttgggcgagttacctctc


(SEQ. ID. No.

601115521F1
acttctttgtgccccagtgttctccttgggaaactggatttaggttagatgacct


81)

/CLONE = IMAGE:
tttaaggctccttgtatgatattttgtgatctgtacatggcagagtatagattag




3356236
gagccaaattttccaacctagtgctatggttcagaatacatagcaccccaagcgt





ctggctggagccgaggatgggtcctccagtattggcacagatgttccggagccca





ggaagcatcccataaccaaccttcagccccaccgccacccccagcgtattccaga





gccgcttccaaaccacagcctatcctctgctccatttcactcttgccctcacaga





ctttcagcctccatgctctgagacaactgtgggtaggtacatctctgttggtgga





229035_s_at
Human
/DB XREF = we88c03.x1
ctgccctcgctgctggaaggcaaggggccgttctcgccttggttttctaggttgt


(SEQ. ID. No.

/CLONE = IMAGE:
gttgcggcaggagctgactgcccctaggcctagatctctgcacaacttcgctcag


82)

2348164
ggacacctgcctctgtgcatgtctcatggtgtgaatgtgtttcctgctcacaggt





accgttttgtgtcatgcagttactggaatgtacaaaagcagctgtgatctttgtg





agagctgcacagagcaggagtctgagagctgcacagagcaggagtctttatttgg





ttcacttctggtctgcagcaaccacttgctactaaaagatggaaaagatgtacaa





aaatgtcacagccctttagaaagngacattatcagaaatgtatgaccttcagtcc





tccctccctctcctatgcccccaccagaccaggcggcgagaagga





229384_at
Human
/DB_XREF = ho39h11.x1
cacagtgagttgcaggttcaccccagcgtcagtggcgggcgggaagtggggatga


(SEQ. ID. No.

/CLONE = IMAGE:
cacaaggacctgagtgtccaagggggcttcatggagccctcatgtgaagtcccca


83)

3039813
gcatggaccctgacacatcgtaggtcctcaacaaatgtcactccctgttgtcact





ctgtttagtactaagaataatgatataaaactgggacagtaaggaaaacacaaac





tgttgggacctatatctgaatctattagtctgcctaatagaaaagccaccatcag





gattttggagattacaagctcactttagattagccatactggagtcagccctgga





ggctcccagagatcagaacaatcccagcgcttgacaggatggctgggaaacaata





catatgaatgccggaaaatgcagaactaatctaggaaaaagtgtaagaagaaaat





aaacatcatctgtcattctatctatcagagataactgctgtcaatattttggttt





ccttccaatattttttctattcactctgtgcat





229421_s_at
Human
/DB_XREF = nab38b03.x1
cctagctcctcaagtgtgcttttttaatatatagttgatatattattgaaggtac


(SEQ. ID. No.

/CLONE = IMAGE:
tacaaaatagaaatctctggagtgcagaagttaagaaaataaccttcatactgaa


84)

3268156
aatatatccttaaaaaaacaacaacaaaaacctctatacaaatgtagtacagcat





acaaatttttaaaagatggaatgaaggcacgaaccattgcaagtcttttggaaat





gtatgaacgtaggcatgctaagttgaaaatagtcttaaaaaactagtgaaaactt





catgtatataaaataattcagaaataaatctgctaacattcttcactttcaggtt





gcatgtgtgaatccaacatgttccttcttcataaatagtcaagcgttccttcagt





ggtgtttgtgtggtctgtcttcgtgctggtcaccagcctcagtatgtctggtaga





cgtcggggatggggacctgaatggcagcag





229534_at
Human
/DB_XREF = zk70e10.s1
taagcacagtagcattccaccattgggctatgacctgaggagaatcaangtagcn


(SEQ. ID. No.

/CLONE = IMAGE:
ttntnaggcctngtggacatcgtggatatnaaggaatgctctcgtaggagggtac


85)

488202
aagaaccccancatgattccaatagagaaggcccaggggcccatcctgctcattg





ttggtcaggatgaccataactggagaagtgagttgtatgcccaaacagtctctga





acggttacaggcccatggaaaggaaaaaccccagatcatctgttaccctgggact





gggcattacatcgagcctccttacttccccctgtgcccagcttcccttcacagat





tactgaacaaacatgttatatggggtggggagcccagggctcattctaaggccca





ggaagatgcctggaagcaaattctagccttcttctgcaaacacctgggaggtacc





cagaaaacagctgtccctaaattgtaatgcatttgtctgttgttgacatgagaga





ttcaagatcagattctagtgttcagtaaccctatg





229570_at
Human
/DB_XREF = hv48b07.x1
gcctcgggagccccgaatagcagctgggagaaggggcgaggactngagcctcnnn


(SEQ. ID. No.

(CLONE = IMAGE:
nnccnctgccggccgggctagagatacgggcgtgccccccattgtgcgcctcccg


86)

3176629
cccntccggtcccctcaccctgcggccacntggggcgtggggcggtgctcctgcc





cgtgcacgtagccgctgcgagcggaggcctgctcacctggtgcctgctactcact





cccccgggccggtgggcgaaggacacccgcaggaactcggcagaggagaaattca





gacggctcccgagggtaggaaaagaccccggcccaccgtggaatctgaaacaccc





gaccactctgccatcccatgtttcaccagtcagacccccagggcagggcagggga





agcagaatgcaaactggggcaccgtttccctgaagcgtgttggccgcgtttgtcg





tagtgctagaggtgcatacccttggac





230048_at
Human
/DB_XREF = 7j53a06.x1
tagtgcaagcaacatgccatttcaaatccgtagacttgtttctttgatactcttg


(SEQ. ID. No.

/CLONE = IMAGE:
ctgtaggtcgccgtgaggggtagggaagcatatatactgtagggagaagtatcaa


87)

3390130
aatcatttaaggtcttttttccaaactagtgttcccctcccacatcccaataact





cttggaagtctggtgctccctctaggtgaaaatcatttgctggcttatggagtca





ctgttgctgagtcccatcccccagttacagtgcagtggaaaacaggtttagaatc





tagaacttgtttgtatgttgtcacttggttatgttccaagtaggttagaaccatg





gaaaagagattgcaaatggtagtttcttctag





230791_at
Human
/DB_XREF = AU146924
gtggttgtatgtgtctgatggcttatgtaaacatagaagaagtcttcagatggct


(SEQ. ID. No.

/CLONE = HEMBB1001899
aaaataaacatgcgcgtgttaccaaaggatatgtttacacaaaccatttgctcag


88)


cctctgaaataatgaataaatgaagattttactaaaataattgggaggatttttg





tgtttctgcggatgccataattgaatggcaccaaagagacttttatcagctattt





tccgtgttacatgtgttagcagttcctttctgtgggttgaatacttcattctgta





gttactttacacatgtttttctaagaaattgtcgtttattactgcaattctagag





agttgcttgatttctcaagagaaatttagcagccagtaaaggttatttggatctg





gttggtcag





230922_x_at
Human
/DB_XREF = ym01a03.s1
gttctcatgagatctggcacttcacccctcactctctcttgctcctgctttggcc


(SEQ. ID. No.

/CLONE = IMAGE:
atgtggagtgctcactccccttttgccttctgccatggctgtaagtttcntgagg


89)

46241
cgtccccagaagncccatcagataccagtgccatgcttcctgtacagcccatgga





actgtgagccaactaaacctcttttatttataaattaccgagtctcaggcacttt





ttatagcaatgcaacaatggactaatacatatactttagcataaaaacatttaaa





agagtctgaaactggagtagttaactcagtaaaaataacttggcaataaaacaca





gaaaaacaatctatttgatcatgtagtgattcctaatgtaaatcctagtacaact





gtcaactgat





230983_at
Human
/DB_XREF = 7e87b12.x1
cttgctgtgagccttttgggtttgtttcctagctccaaatcttaacttggtgtca


(SEQ. ID. No.

/CLONE = IMAGE:
agtttcctggctuggagacaagcttttaccgacttcctctgcttgccagcaaagt


90)

3292127
catctgctaactggatattggcagcttctctgctgtcttgcagctgcttccggag





tgggttccacagggattcccgtgtgttcttggttcagcttgcagagggactttca





cactccctggagaccgtttcctcccattctgtctggagttttcggcctaccccaa





gacaatgagatattcctgacctttccacctatttccctccaaccccaccttccga





aatacatttgct





231271_x_at
Human
/DB_XREF = oz47c03.x1
gtcagggaccgagacaatagtggctntgggtgtagcaggtcgggagaccccagcc


(SEQ. ID. No.

/CLONE = IMAGE:
catccggcctccctgccccgccacctcccggggcantggaggacgccggccacga


91)

1678468
caggctcctctgcttccagatgactcctgaggactacgaaaagcttggctttccc





ggtgcccgggacctggccaacatgttccgtttntatgccctgagacccgaccgtg





acatcgagctgaccctgagactcaaccccaaggccctgacgctggaccagtggct





ggaacagcacaaaggggacttcaacctgctgtgacctgcccgcctcgcggcccct





tgtggggatcgggggcaccagaggggcagaggcaccaacatctgaataaagccat





t





232524_x_at
Human
IDEF = Homosapiens
atctacattatcttctttttactattctagaagattcactttataaaatgtgcat


(SEQ. ID. No.

cDNA FLJ11019 fis,
cttaaggagacatactgatatttctcaatctgtgagtaatggactaattgctatt


92)

clone PLACE1003611.
aaatttgggagctttacatatgccacaacagaaaaagtcagaagaagcatctaca





gttgtttagatgcacagttttatgatgatgaaactgtaacagtagttcttaaaga





cactgtaggacgtgaaggaagagatagactcttggtccagctgcctttgtcttta





gtatataacagtgaagattctgcagaatatcagttcactgggacttattctacaa





ggctagatgaacagtgtagtgctattcccacccgtaccatgcatttcgagaagca





ctggagattactggaaagtatgaaagcacagtatgttgctgggaatggttttcga





aaagtgtcctgtgtgttaagctcaaatcttcgtcatgtgagagtatttgaaatgg





acatagatgatgaatgggagctcgatgagtcttcag





232527_at
Human
/DB_XREF = AU146179
gagttgatggtgttgctgggttataancagcttcaaagagaaggcattttgaatg


(SEQ. ID. No.

/CLONE = HEMBA1007062
aaggtggaaacataatggccaggagaacaagcaaaggactaggaancagtgaact


93)


tcatcttggcctcaagttcctgaggtgcatatgaataaacagtctctaacccaga





gggtttcaagaaaagcagagtcctcaaaatccaaaggtagagtttccccacattg





atattatactaattacacgtataacagtactttggaaaagcacaggtctctggtc





acctctaaaaggcaaggttggtaaggaggtcagggtgtcacctgttggtagtctt





aactaaatggtctcttcaagggatctaaggatggaaaggggatatataatggttg





gattaaaggctcatcattgattagcaaattgtcccttttgtttctt





233214_at
Human
/DEF = Homosapiens
aaaccagcctttggagagggcctcatggcaagaaactaagggtggcctctagcca


(SEQ. ID. No.

cDNA FLJ11900 fis,
gtagtcagcaagaaaacagatccttgttctagtagtgtgccaggaactgaagatt


94)

clone HEMBA1007341.
gccaacaaccttgttattttggaagtgaatcctggttcagtggagccctagctga





gaccttagctctggctaacaccttgattgcagtcttttgagaccaggaaacagaa





agaagccagctaatctgtgcttggactcctgacccacagaacctgtgagataata





aatgtgtcttgttcttaacacaccagatttgtggtaatattgttacacagtgtag





aaaactaacaaactaggcctcaaaataaatctataaacagttttgcaggtacact





gtagaacacacaataaaaagtagccacagaaagagacatgagtgaataccagcag





gagcttctattta





233302_at
Human
/DB_XREF = AU146285
tgtgtgtctaagcaattctggcccctggctcccaccaccctaccctctccacaaa


(SEQ. ID. No.

/CLONE = HEMBB1000025
ataatagacattaggggaggtaagggancagaagaggtctcttngcagatattat


95)


atttttaaaaantggttctatgntaataagcagcagctaaggagacagaaagnca





gtagatgaagagagtgccaatatcttccatggggaaaaatgaatgaactgaaaga





gaatattatttttctagaatacagaaagctgtcctctcacagatcagctggaatt





ccaaggtggattatggacttcttctaactcccattgatagtgcttcttaccaggt





gaagggaagggctactttttcctaaaggagaaaaaagctttcagacaaagctcgt





accaacccctgaactgcaaatttgctcaagtgaccgtgcatacttatattcctaa





tttaaatgattatttatgtcaaacgctcattgtgaaactt





233429_at
Human
/DB_XREF = qm62e07.x1
ttgggcaccacttccatcaggaaaacagtgtgcaagatggagaaactaaggacaa


(SEQ. ID. No.

/CLONE = IMAGE:
accccagagaaactggacaaacccagcagaagaaaggaagaactgcaactcagaa


96)

1893348
atcacataaccaccaagcaggtntggaccacacatgctaaatgtgcatccactat





ggcgagtcccaggcctttaacagcagggactaaggagggcagaggctgacaccaa





ccccctttcatactgtagcactacatccctctcagataccagtttaacacgaagt





ctccctgtttgactcctgtgagttgtgtattgaactanaaagtgnttnctgagtt





naaaataaaagcgcnntnncnnnnnnanaannnanattgtgtatcttgacttctc





aatgatagcaagttacattttgcagttttcttcctatacccacaaatgaaactat





tcagacttaaatatcttcctgtgtgcctaaacgtt





233440_at
Human
/DB_XREF =
taagaaatgtcgaaggaggccgggcgcggtggttcatgcctgtaatcccagcact


(SEQ. ID. No.

DKFZp761l07121_s1
ttgggaggccgaggcgggcggatcacgaggtcaggagatcgagaccatcctggct


97)

/CLONE =
aacacggagaaaccccgtctctactaaaaatacaaaaaattagccgggcgtgtgg




DKFZp761l07121
cgggcacctgtagtcccagctacttgggaggctgaggcaggagaatggcgtgaac





ccgggaggcggagcttgcagtgngccangatcgcgccactgcaccccagcctggg





agacagagcgagactccgtctcaaaaaaaaaaaaaannngacaaaggaaattctt





ctagttcctttaaggatttctctagcacaggatcagagaggatcttggttattgg





tgactggtgagattctgttgggtgtttggaagcttcaaatgcatggagccacccc





ttaaaaatgtctcactggaggcaggcacggtggcttatgcctgtaatccmgcatt





ttaggaggccgangcaggtggatggcttgagtatatatacttcgcgagcaccgtg





g





233493_at
Human
/DEF = Homo sapiens
atgagaacatggtcttggccggagcaatttctgggctggtgggacccttgtccac


(SEQ. ID. No.

PAC clone RP5-988G15 
aattgtagtttcatatatgtgcatcctctgtgctatccttcagatccaatcaagg


98)

from 7q33-q35
gaagttcagaggaaagccttccgcacctgcttctcccacctctgtgtgattggac





tcgtttatggcacagccattatcatgtatgttggacccagatatgggaaccccaa





ggagcagaagaaatatctcctgctgtttcacagcctctttaatcccatgctcaat





ccccttatctgtagtcttag





233599_at
Human
/DEF = Homosapiens
ctgtgttgttttgctggtggccacgaatccgaaaggcccatgctgcagcgtgccc


(SEQ. ID. No.

cDNA: FLJ21498 fis,
ntgctttgagtttggttgatatgcnttaataagaacattagttttcntgggagaa


99)

clone COL05627.
tttggtagcacccgttcttcccttcactgtgtgggggaaatagtgttgattgaaa





ggaagaggactccgagattggattggagcaagaaagtgtgggtatcgtgtgttgt





gactgtgtcttctccggggtgctgcttcactggaggtctccnttcagggtctggc





cctcatgcctggccccaggtgctcgtgtgcacgtgagcggctcttcctgctgact





gactacagctaatt





234735_s_at
Human
/DEF = Homo sapiens
caaagattccctcgaatcctcgtgctccatctgaatcgattttctgcctcccgag


(SEQ. ID. No.

clone PP1490
gctccatcaaaaaaagttcagtaggtgtagactttccactgcagcgactgagcct


100)

unknown mRNA.
aggggactttgccagtgacaaagccggcagcgtccactatggccactacacagcc




/PROD = unknown
ctgtgccggtgccagactggttggcatgtctacaatgactctcgtgtctcccctg





tcagtgaaaaccaggtggcatccagcgagggttacgtgctgttctaccaactgat





gcaggagccaccccggtgcctgtgacacctctaagctctggcacctgtgaagccc





tttaaacacccttaagccccaggctccccgtttacctcagagacgtctatt





235363_at
Human
/DB_XREF = 7l45h09.x1
cccgaagagcacccagcatatagctctcatttgttgattctgttagatcatgatc


(SEQ.

/CLONE = IMAGE:
aatgttaagcctaaaaacaaggtggccacatcagtggtttgtaacccatgtttat


ID. No.

3524585
tctaatcagtcaatctggggctatatataatagtagttgaatgtttatagtacta


101)


cccttnggaaaattcccatatattcncncccagcatggatataaatacnggaaag





atttcccattgagtacttctctttagcactccagntaacactagacaaataagca





cctaaatgccgagtgtttgtcagttttaaaattagaaaagaaggcaagttgtttt





cttgtctacctgtttaataaattttttattgnccaagtanntatgttcatttgat





ttaatacgttgaaatgtagtttaaaatatatattcaaataactaacaa





235467_s_at
Human
/DB_XREF = 602272817F1
cctctcttaaagcggcaccaacgtgagagagacaggcagacagacagaaagccag


(SEQ. ID. No.

/CLONE = IMAGE:
aggcttagggaaactctggaacccagacaagaatcttacgctgggaaagactcag


102)

4360612
atatccttgtttgcacaggactggtggaaaatctcccatgcgaccctcggggccc





agagccatctgggtctgatgttctgttccattgtacatcgaagagatatatatgc





acatatagtatctatattcatacatattatactcttgtgtgtagtgca





235634_at
Human
/DB_XREF = 7a17e03.x1
tcatcaagcctttcgttttcaaaccaccatttgtcagccttgaggtagagagaca


(SEQ.

/CLONE = IMAGE:
tatagatttgaaaatactttcttaagagatcatgtaactatataactctgaattt


ID. No.

3219004
aaaaattgaggggggagggataatttcaacccactgcctcttaccagaaacattt


103)


ttttaaatctgtaactgctttagtgttaacagggtgcaaggtggtttttgtcccg





tattgttcttaaaaggactcatttattgtgattgtattgtactgtatgagaacaa





antcataaattgccttgtattgtttataatagaccataccacgtactacttcagt





attatgttccaagtattcagtgatgcatgttaacagttaggtcctaaaattctgt





ggtgctaattctcccatacccaatggtgcttttgtggatgctaactgcacacatg





ctgaac





236312_at
Human
/DB_XREF = oc10d11.s1
cctatccctggccaaggaagtatgcaaattgtattgtggtttttgaagtttaggt


(SEQ. ID. No.

/CLONE = IMAGE:
gatctcttccttctatccctagccaaggaagttcatcctgactccccaacaagca


104)

1340469
tatcaaaaggagtgtttcgtcacctttttcctcttaccctttacatccttttagc





aataaagtgttcagaacaaactggttttcctttactgtgctttgcaaaacttatt





catgttttattgggtgactttgtatttacactttcctcagatagtctgttgtcag





atgactttgaccaatgattgggaggaaccaaatacagaggattttatcctatgcc





taatctatattgtctacagagtaaatcaggtntgaatttgtgaacagtaatgaaa





caattttccaactaatcagaagaattgtttgttaagtaaccttaattactcagtt





tttggtgaattgtttgcggcttaacttg





236875_at
Human
/DB_XREF = wb57e03.x1
gaaggagagctgttctgcatccataaaaaccagttaaaagggatttcataaggtc


(SEQ. ID. No.

/CLONE = IMAGE:
tgaaattgagaactttcccaagaatactgcatcttgttctcttgtgcaatataca


105)

2384860
gacgtgtgaatattcctaacagtaaccaaatgggtgcactctctgtgaaaacgca





tctttcaaagagttttttaaacaaaggagactcctgggcctttagaaataattgc





cacaaactgcaaaaacaatctccaacctcccacttctgtaattctcatctgttgt





cttactagaaaatttatttctctggtaataatgttataattgatatccctgtctt





ctcaagatgtaaaatacttgtaaaaacttctctgtccatcagaaaat





237023_at
Human
/DB_XREF = 7q84f05.x1
tagaaagataattccgtctctcctttggcagtaggcatgtccctgtgagggagga


(SEQ. ID. No.

/CLONE = IMAGE:
gatcagcaggatttttccaagcacctgtcaaaaccctgntgatcaaaacagaaca


106)

3704985
tancaataacaaagaatggccaaaaccagctcggaataggaattaaaatgcattt





gcataagatactcccaccagggccatgacagtttacaaatgatcccacggcaata





acccaggaattatcttatatggttccaggaacttcctgttcctagtttatgaata





acctgcctcttatttagcatataattagcagtggbtataaatatagctagccagc





aatcctggagtgctattctacctgtggggtagccctgctctgtctgtggagcagc





cattttgctgtac





239496_at
Human
/DB_XREF = xy02b11.x1
gtagagatgggctgtcttgccttagagacattaaggtctgttataaagctataat


(SEQ. ID. No.

/CLONE = IMAGE:
aacgaagacagcctggtattagggtgccagtgtagttacagacaaagagaccaat


107)

2851965
ggaacaggataaaaagcccataaataatctcatgcatatatgcacacttgactta





caatggaaggagtattgcagatcagtggggagagactgaactaatcaataaatca





tgcagttacaagatcatacatgtggagaaacaaaatgaaaccagatcctgaagta





cacaaaaaatcggttccaggtatattgaatat





240130_at
Human
/DB_XREF = yd76e12.s1
attacttgaccaattttcatagcaaactgattggnttcacttatccccccactga


(SEQ. ID. No.

/CLONE = IMAGE:
actgttaagacctggcgagatcctttttatagttctttaaacttccaggactttc


108)

114190
tgcttatcttcaggaaggacagtggaccttcaggggagaggagaaggaggaaatt





tgcatatttaaaatgtgtgatctgagccaaacgctcttcagctaacttgatctcg





catcattttcccagcttcctttgagaattcagaatcaaaattcaggcatcaccat





ctagtgaccacagggtcctgcaccccagcccaaacctggggancccttagggata





atgccctttctcatttgtcttt





241395_at
Human
/DB_XREF = AL572553
attctgactgtatcactgaaaggctgtgtagctgtgtgaccgtaagcaagtcact


(SEQ. ID. No.

/CLONE = CSODI008YD03
taactccagattctcagtgctgtcatctataaacagggatgaatgaatatacacc


109)

(3 prime)
tcagagttgttaagaatccaatgagaaaatcacgggtaacccttatataaatggt





tgtgaaacatttcaaagatacaagcatccttggcctttgcagcccagaatcatcc





ctccacatttttcctacaatccaaccacatcaagaaatgataactgctcagaaag





tttatcaatatttaccaaaactcatggatttaaaataaacattaagtttctncaa





taaaaaannnnnnaattctatgccatttgtactcccttgatcttcaccctatttg





gcaatatcaactttttttttttgagatggagtctcactttgtcacccaggctgca





ttgcacgtggtgcaa





242171_at
Human
/DB_XREF = zi55d08.s1
gtcattgctggtcaatgaagcatactaacagaccaatctgagcagtaattgtcct


(SEQ. ID. No.

/CLONE = IMAGE:
tgcataagcaagattttttttttttttgatggtaatgagtgatttcaaaaatacg


110)

434703
tttaggctgggtatggtggttcttgcctgtaatcccagcaactttgggaggccaa





ggtaggaggatcactcgaggccaggagttcatgaccgtcctggtcaacagagtaa





gacctcgtctctgcaaaacaaaataaaataaaataaaataaaaaacttaaaaaat





catgcacctatagtcccaactgctcaagaagctgaggtgagattgcttgaggcca





ggagttagaggctgcagtgtgtgattgcccactgcattc





242602_x_at
Human
/DB_XREF = wz04g07.x1
ttcttgacccattacaatctcttctacgggcaaagctgagggactgttgacattt


(SEQ. ID. No.

/CLONE = IMAGE:
agggatgtggccatagaattctctctggaggagtggcaacacctggacattgcac


111)

2557116
agcagaatttatatagaaatgtgatgttagagaactacagaaacctggccttcct





gggtattgctgtctctaagccagacctgatcacctgtctggaacaagggaaagag





ccctggaatatgaagcgacatgagatggtggatgaacccccnggattggattttt





cattactgtgaagaaaaacactggaattttgataaggagttctttaaatctacag





gtcactttggataat





242606_at
Human
/DB_XREF =
ggatttagttgccatgtatcttcagtttcaattttnctttgtcttttcataacat


(SEQ. ID. No.

DKFZp434B1827_r1
tgactttttttaagagaacagctggtggttttatagaattccatcaatttgggtt


112)

/CLONE =
tgtcagattattggcttatgattagattcagttatgaattttggcaaggatattg




DKFZp434B1827
cagaagttatgataggttcttcttagtgcaacttatcacgatacacatgatgtct





gtttgtcccattattggtgatgttaacttccgtaacttgctccattgaaa





243003_at
Human
/DB_XREF = AV702197
agtattgaaattcctcgagccgctgcttttctcactccataattctggccagaat


(SEQ. ID. No.

/CLONE = ADBCOH08
ttggtacttaaaatattttgtctaaaatattacaatagctacttaagtcatctcc


113)


ctgactccactctgttgtctttcagggcgtcgtccacactgtagccaaagtgatc





ttataaaaacataattctaatcatggcactcttctgcttaaaaatgttttaatgg





ctttccgttaggttaaaatttaaaagtcctttgtagcctgtgagactctacatga





gttgactccctagcttcatctttgagcatcttatttctttacttattataccatc





agttagagttgattgttatataatccacagaagtgaattctgtccgatttaagc





243185_at
Human
/DB_XREF = nz37f07.s1
ttccctccccagtcttagagactgatcactggggcagagtgacattttcccacaa


(SEQ. ID. No.

/CLONE = IMAGE:
tgctggctcattattttcctcctggaatngcaaatccaagggacaagtggtacag


114)

1289989
cctgncaccnatccagaaggggagggaatcccaccagaggtgccctgaaacaaag





aanacaagtaacttcaaaaccacatcctaaaatctggacctgtgacaggacagat





ggaactctggattgtttgattctatcagcagaacagaggaaggaaatgttttaaa





acgagattatgttattttccccagttattatgaagccttcctgaaatgaacttta





aatatcggccaccactttcatgaggctgaatgggattcagcaattaggagcgttg





cagggaagtgtggcagggcagaggtgggacaaattgcagatccctgtggggtccc





ttggttaggtgacaattagtctataaaacacagctgtgtgtgttagggagggagt





ggtgtctttaaaaagctctgtgcccaataggaacat





31826_at
Human
Cluster Incl.
aaccctgggtctaggcgagccacagggtgaggtcaaggtgagcattctgggaaca


(SEQ. ID. No.

AB014574: Homosapiens
atatttgggctcagagggtgggttggccaccttctgagccccacccccgccagac


115)

mRNA for KIAA0674
ctggtgaagaggatnnnnnnnnnnnnnnnnnnnnnnnnnnnnannnnnnnnnnnn




protein, partial cds
gttggaagaaggactggtaggttcccctccaagccagtcacctgtaagagtcctg




/cds =(0,3704)
tcctctgccagactttttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagccc




/gb = AB014574
tcntnnacctgaatccagtgctcaactgtgccccggcaacaagacctgggctgag




/gi = 3327161
gtctccctggtagaacnnnnnnnnnnnnnnnnnnnnnnatcccagtgcagtcaac




/ug = Hs.14799
agcctggcctatagtcctgggacatgtatcttcttctttgccttaaatctgatac




/len = 4263
aagaggtcaat





35150_at
Human
Cluster Incl.
cactgtacgagtgaggcctgtgagagctgtgtcctgcaccgctcatgctcgcccg


(SEQ. ID. No.

X60592: Human CDw40 
gctttggggtcaagcagattgctacaggggtttctgataccatctgcgagccctg


116)

mRNA for nerve growth
cccagtcggcttcttctccaatgtgtcatctgctttcgaaaaatgtcacccttgg




factor receptor-
acaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggcacaaacaagactg




related B-lymphocyte
atgttgtctgtggtccccaggntcggctgagagccctggtggtgatccccatcat




activation molecule
cttcgggntcctgtttgccatcctcttggtgct




/cds = (47,880)





/gb = X60592





/gi = 29850





/ug = Hs.25648





/len = 1004






64474_g_at
Human
Cluster Incl.
ccatctgaagcaagagtccagcgttctgccgtgtctgtcccccaccatgccccct


(SEQ. ID. No.

AA203219: zx56d02.r1
acaggcnnnnnnnnnnnnnnntttttttttttttctgtcnnnaannnaannnnnn


117)


Homosapiens cDNA, 

cntgtgggccgcccacaacatatccttccctcactacctgtgtgaccaaggttgg




5' end
cttctgttgacctttaaaaaagaaaccctcaactcaaattgctataattagacac




/clone = IMAGE-446499
ttgcttctgtcttgcntcctgtctgcagctgtgaatagtcatttgactgtgactg




/clone_end = 5'
ttgcccttagccagccagatgcgcctgtgaaccaaagcttcgtgcacatgtgttc




/gb = AA203219
ccctaaaggttggggagcctcgctgtgtcttgctgttcccaggcaccaccacagc




/g1 = 1799058
agntgnngccatactcttgtggtctctgtgcg




/ug = Hs.59457





/len = 901






91617_at
Human
Cluster Incl.
tttctgtcaggaaaacaatgttggcctgtgggccgcccacaacatatccttccct


(SEQ. ID. No.

Al028241: ow01b03.x1
cactacctgtgtgaccaaggttggcttctgttgacctttaaaaaagaaaccctca


118)


Homosapiens cDNA, 3'

actcaaattgctataattagacacttgcttctgtcttgcctcctgtctgcagctg




end
tgaatagtcatttgactgtgactgttgcccttagccagccagatgcgcctgtgaa




/clone = IMAGE-1645517
ccaaagcttcgtgcacatgtgttcccctaaaggttggggagcctcgctgtgtctt




/clone_end = 3'
gctgttcccaggcaccaccacagcaggtgctgccatactcttgtggtctctgtgc




/gb = A1028241
gcccccccccccccnnnacccgtctgccaagcatgggtatgaatcgtgcacacag




/gi = 3245550
ccatgcttcaaggccggggcaggggagcctgtgctgatgccatccagngcactgg




/ug = Hs.59457
gctgtgcctggaaggcgagccttgattgtctgaacacataaagcaaactgtccag




/len = 752








Claims
  • 1. A diagnostic kit containing a microarray, the microarray comprising the nucleotide sequences of SEQ ID NO.:1 to 118 attached to a substrate, the nucleotide sequences corresponding to the predictive genes of a gene expression profile obtained by a method for providing a gene expression profile being predictive for the specific response of an individual tumor to Avastin, the method comprising the steps of: (a) xenotransplanting human tumor material of at least five different tumors into at least one suitable test animal,(b) determining gene expression profiles of the resulting tumor xenografts,(c) treating said at least one test animal with Avastin,(d) evaluating responsiveness of the tumor xenografts to Avastin,(e) identifying the gene expression profile of each of the tested tumor xenografts, and(f) determining the predictive genes in the gene expression profiles by comparing the gene expression profiles of responsive tumors, no-change tumors and progressive tumors,wherein step (f) comprises the steps of(i) dividing the complete set of gene expression profiles of the tumor xenografts into sub-sets, each of the sub-sets missing one of said gene expression profiles,(ii) determining the predictive genes in each sub-set, and(iii) obtaining the gene expression profile being predictive for the specific response of an individual tumor to Avastin by setting up the intersection of the predictive genes of all sub-sets.
  • 2. The kit according to claim 1, wherein in step (f) a tumor xenograft is considered to be responsive when its T/C (therapy/control) value is less than 25%.
  • 3. The kit according to claim 1, wherein in step (f) a tumor xenograft is considered to be no-change when its T/C (therapy/control) value is ranges from 25% to 42%.
  • 4. The kit according to claim 1, wherein in step (f) a tumor xenograft is considered to be progressive when its T/C (therapy/control) value is more than 42%.
  • 5. The kit according to claim 1, wherein in step (ii) an expression profile of 300 genes is determined for each sub-set.
Priority Claims (1)
Number Date Country Kind
05008088 Apr 2005 EP regional
PCT Information
Filing Document Filing Date Country Kind 371c Date
PCT/EP2006/003421 4/13/2006 WO 00 12/11/2007
Publishing Document Publishing Date Country Kind
WO2006/108659 10/19/2006 WO A
Foreign Referenced Citations (2)
Number Date Country
03057916 Jul 2003 WO
2004111603 Dec 2004 WO
Non-Patent Literature Citations (5)
Entry
Zembutsu et al. IDS—Citation No. 2, Oct. 11, 2007.
Zembutsu, H., et al., “Gene-expression profiles of human tumor xenografts in nude mice treated orally with the EGFR tyrosine kinase inhibitor ZD1839,” International Journal of Oncology, 2003, 23(1):29-39.
Zembutsu, H., et al., “Genome-wide cDNA Microarray Screening to Correlate Gene Expression Profiles with Sensitivity of 85 Human Cancer Xenografts to Anticancer Drugs,” Cancer Research, Jan. 15, 2002, 62:518-527.
Bergsland, E., et al., “Maximizing the Potential of Bevacizumab in Cancer Treatment,” The Oncologist, 2004, 9(suppl 1):36-42.
Ghadimi, B.M., et al., “Effectiveness of Gene Expression Profiling for Response Prediction of Rectal Adenocarcinomas to Preoperative Chemoradiotherapy,” Journal of Clinical Oncology, Mar. 20, 2005, 23(9):1826-1838.
Related Publications (1)
Number Date Country
20110243925 A1 Oct 2011 US
Provisional Applications (1)
Number Date Country
60670863 Apr 2005 US