Gene expression profiles in liver cancer

BACKGROUND OF THE INVENTION

[0002] Primary hepatocellular carcinoma (HCC) is a widespread cancer throughout the world, especially prevalent where the incidence of chronic hepatitis B (HBV) and hepatitis C (HCV) viral infections are endemic (Groen, (1999) Semin. Oncol. Nurs. 15, 48-57; Idilman et al., (1998) J. Viral. Hepat. 5, 110-117; Di Bisceglie et al., (1998) Hepatol. 28, 1161-1165; Johnson, (1997) Hepatogastroenerology 44, 307-312; Sheu, (1997) J. Gastroeneterol. Hepatol. 12, S309-313). Hepatocellular carcinomas are very malignant tumors that generally offer a poor prognosis, dependent on the size of the tumor, the effect on normal liver functions, and the involvement of metastases. They are best treated by surgical resection, when the tumors are diagnosed at a stage where this is a viable possibility, but the recurrence rate for these cancers remains high (Johnson, (1997) Hepatogastroenterology 44, 307-312; Schafer & Sorrell, (1999) Lancet 353, 1253-1257; Groen, (1999) Semin. Oncol. Nurs. 15, 48-57; Sitzman, (1995) World. J. Surg. 19, 790-794; DiCarlo, (1995) Hepato-Gastroenterol. 42, 222-259; Tanaka et al., (1996) Hepato-Gastroenterol. 43, 1172-1181; El-Assal et al., (1997) Surgery 122, 571-577).

[0003] Numerous risk factors for the development of HCC have been identified: cirrhosis, HBV or HCV infection, being male, alcohol-related liver disease, exposure to aflatoxins, vinyl chloride and radioactive thorium dioxide, cigarette smoking, ingestion of inorganic arsenic, the use of oral contraceptives and anabolic steroids, iron accumulation, and various inherited metabolic disorders (hemochromatosis, glycogen storage disease, porphyria, tyrosinemia, α-1-antitrypsin deficiency) (Di Bisceglie et al., (1998) Hepatol. 28, 1161-1165; Chen et al., (1997) J. Gastroenterol. Hepatol. 12, S294-308; Schafer & Sorrell (1999) Lancet 353, 1253-1257; Groen, (1999) Semin. Oncol. Nurs. 15, 48-57; Idilman et al., (1998) J. Viral. Hepat. 5, 110-117; Johnson, (1997) Hepato-Gastroenterol. 44, 307-312).

[0004] In addition to liver tumors attributed to hepatocellular carcinoma, there are liver tumors that arise as metastases from primary tumors in other parts of the body. These tumors most often metastasize from the gastrointestinal organs, primarily the colon and rectum, but it is possible for metastatic liver cancers to occur from primary cancers throughout the body (Sitzman 1990, Groen 1999). These cancers can be treated using the routine therapies such as chemotherapy, radiotherapy, surgical resection, liver transplantation, chemoembolization, cryosurgery, or a combination of therapies (Sitzman, (1990) Hepatic Neoplasia, in Bayless (editor) Current Therapy in Gastroenterology and Liver Disease, Marcel Dekker; Groen, (1999) Semin. Oncol. Nurs. 15, 48-57).

[0005] The characterization of genes that are differentially expressed in tumorigenesis is an important step in identifying those that are intimately involved in the details of a cell's transformation from normal to cancerous. Studies examining the gene expression of metastatic liver tumors and hepatocellular carcinomas in comparison with a set of normal liver tissues would produce data identifying genes that are not expressed in normal livers but have been switched on in tumors, as well as genes that have been completely turned off in these tumors during the progression from a normal to a malignant state. Such studies would also lead to the identification of genes that are expressed in tumor tissue at differing levels, but not expressed at any level in normal liver tissue. The identification of genes and ESTs that are expressed in both types of tumors, i.e., primary hepatocellular carcinomas as well as metastatic tumors of a different origin, and not in normal liver cells would be extremely valuable for the diagnosis of liver cancer.

SUMMARY OF THE INVENTION

[0006] The present invention identifies the global changes in gene expression associated with liver cancer by examining gene expression in tissue from normal liver, metastatic malignant liver and hepatocellular carcinoma. The present invention also identifies expression profiles which serve as useful diagnostic markers as well as markers that can be used to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.

[0007] The invention includes methods of diagnosing the presence or absence of liver cancer in a patient comprising the step of detecting the level of expression in a tissue sample of two or more genes from Tables 3-9; wherein differential expression of the genes in Tables 3-9 is indicative of liver cancer. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5. In some preferred embodiments, the method may include detecting the expression level of one or more genes selected from a group consisting Tetraspan NET-6 protein; collagen, type V, alpha; and glypican 3.

[0008] The invention also includes methods of detecting the progression of liver cancer and/or differentiating nonmetastatic from metastatic disease. For instance, methods of the invention include detecting the progression of liver cancer in a patient comprising the step of detecting the level of expression in a tissue sample of two or more genes from 3-9; wherein differential expression of the genes in Tables 3-9 is indicative of liver cancer progression. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5.

[0009] In some aspects, the present invention provides a method of monitoring the treatment of a patient with liver cancer, comprising administering a pharmaceutical composition to the patient and preparing a gene expression profile from a cell or tissue sample from the patient and comparing the patient gene expression profile to a gene expression from a cell population comprising normal liver cells or to a gene expression profile from a cell population comprising liver cancer cells or to both. In some preferred embodiments, the gene profile will include the expression level of one or more genes in Tables 3-9. In other preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5.

[0010] In another aspect, the present invention provides a method of treating a patient with liver cancer, comprising administering to the patient a pharmaceutical composition, wherein the composition alters the expression of at least one gene in Tables 3-9, preparing a gene expression profile from a cell or tissue sample from the patient comprising tumor cells and comparing the patient expression profile to a gene expression profile from an untreated cell population comprising liver cancer cells. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5.

[0011] In one aspect, the present invention provides a method of diagnosing hepatocellular carcinoma in a patient, comprising detecting the level of expression in a tissue sample of two or more genes from Tables 3-9, wherein differential expression of the genes in Tables 3-9 is indicative of hepatocellular carcinoma. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3 or 5

[0012] In another aspect, the present invention provides a method of detecting the progression of hepatocellular carcinoma in a patient, comprising detecting the level of expression in a tissue sample of two or more genes from Tables 3-9; wherein differential expression of the genes in Tables 3-9 is indicative of hepatocellular carcinoma progression. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3 or 5.

[0013] The present invention also provides materials and methods for monitoring the treatment of a patient with a hepatocellular caricnoma. The present invention provides a method of monitoring the treatment of a patient with hepatocellular carcinoma, comprising administering a pharmaceutical composition to the patient, preparing a gene expression profile from a cell or tissue sample from the patient and comparing the patient gene expression profile to a gene expression from a cell population comprising normal liver cells or to a gene expression profile from a cell population comprising hepatocellular carcinoma cells or to both. In some preferred embodiments, the method may include detecting the level of expression of one or more genes from the genes listed in Tables 3-9. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3 or 5.

[0014] In a related aspect, the present invention provides a method of treating a patient with hepatocellular carcinoma, comprising administering to the patient a pharmaceutical composition, wherein the composition alters the expression of at least one gene in Tables 3-9, preparing a gene expression profile from a cell or tissue sample from the patient comprising hepatocellular carcinoma cells and comparing the patient expression profile to a gene expression profile from an untreated cell population comprising hepatocellular carcinoma cells. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3 or 5.

[0015] The present invention provides a method of diagnosing a metastatic liver tumor in a patient, comprising detecting the level of expression in a tissue sample of two or more genes from Tables 3-9, wherein differential expression of the genes in Tables 3-9 is indicative of hepatocellular carcinoma. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 4 or 5.

[0016] The present invention provides a method of detecting the progression of a metastatic liver tumor in a patient, comprising detecting the level of expression in a tissue sample of two or more genes from Tables 3-9, wherein differential expression of the genes in Tables 3-9 is indicative of a metastatic liver tumor progression. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 4 or 5.

[0017] In a related aspect, the present invention provides a method of monitoring the treatment of a patient with a metastatic liver tumor, comprising administering a pharmaceutical composition to the patient, preparing a gene expression profile from a cell or tissue sample from the patient and comparing the patient gene expression profile to a gene expression from a cell population comprising normal liver cells or to a gene expression profile from a cell population comprising metastatic liver tumor cells or to both. In some preferred embodiments, the method of the present invention may include detecting the expression level of one or more genes selected from the genes listed in Tables 3-9. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 4 or 5.

[0018] In some preferred embodiments, the present invention provides a method of treating a patient with a metastatic liver tumor, comprising administering to the patient a pharmaceutical composition, wherein the composition alters the expression of at least one gene in Tables 3-9, preparing a gene expression profile from a cell or tissue sample from the patient comprising metastatic liver tumor cells and comparing the patient expression profile to a gene expression profile from an untreated cell population comprising metastatic liver tumor cells. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 4 or 5.

[0019] The invention also includes methods of differentiating metastatic liver cancer from hepatocellular carcinoma in a patient comprising the step of detecting the level of expression in a tissue sample of two or more genes from Tables 3-9; wherein differential expression of the genes in Tables 3-9 is indicative of metastatic liver cancer rather than hepatocellular carcinoma.

[0020] The invention further includes methods of screening for an agent capable of modulating the onset or progression of liver cancer, comprising the steps of exposing a cell to the agent; and detecting the expression level of two or more genes from Tables 3-9. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5.

[0021] Any of the methods of the invention described above may include the detection of at least 2 genes from the tables. Preferred methods may detect all or nearly all of the genes in the tables. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5.

[0022] The invention further includes compositions comprising at least two oligonucleotides, wherein each of the oligonucleotides comprises a sequence that specifically hybridizes to a gene in Tables 3-9 as well as solid supports comprising at least two probes, wherein each of the probes comprises a sequence that specifically hybridizes to a gene in Tables 3-9. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5.

[0023] The invention further includes computer systems comprising a database containing information identifying the expression level in liver tissue of a set of genes comprising at least two genes in Tables 3-9; and a user interface to view the information. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5. The database may further include sequence information for the genes, information identifying the expression level for the set of genes in normal liver tissue and malignant tissue (metastatic and nonmetastatic) and may contain links to external databases such as GenBank.

[0024] The invention further comprises kits useful for the practice of one or more of the methods of the invention. In some preferred embodiments, a kit may contain one or more solid supports having attached thereto one or more oligonucleotides. The solid support may be a high-density oligonucleotide array. Kits may further comprise one or more reagents for use with the arrays, one or more signal detection and/or array-processing instruments, one or more gene expression databases and one or more analysis and database management software packages.

[0025] Lastly, the invention includes methods of using the databases, such as methods of using the disclosed computer systems to present information identifying the expression level in a tissue or cell of at least one gene in Tables 3-9, comprising the step of comparing the expression level of at least one gene in Tables 3-9 in the tissue or cell to the level of expression of the gene in the database. In some preferred embodiments, one or more genes may be selected from a group consisting of the genes listed in Tables 3-5.

BRIEF DESCRIPTION OF THE DRAWINGS

[0026]
FIG. 1 is a flow chart showing a schematic representation of the experimental protocol.

[0027] FIGS. 2A-2C are graphs of the number of genes present in all samples as a function of the number of samples for the second sample set. FIG. 2A is the Gene Signature Curve for normal liver tissue. FIG. 2B is the Gene Signature Curve for metastatic liver tumor samples. FIG. 2C is the Gene Signature Curve for hepatocellular carinoma samples.

DETAILED DESCRIPTION

[0028] Many biological functions are accomplished by altering the expression of various genes through transcriptional (e.g., through control of initiation, provision of RNA precursors, RNA processing, etc.) and/or translational control. For example, fundamental biological processes such as cell cycle, cell differentiation and cell death, are often characterized by the variations in the expression levels of groups of genes.

[0029] Changes in gene expression also are associated with pathogenesis. For example, the lack of sufficient expression of functional tumor suppressor genes and/or the over expression of oncogene/protooncogenes could lead to tumorgenesis or hyperplastic growth of cells (Marshall, (1991) Cell, 64,313-326; Weinberg, (1991) Science, 254, 1138-1146). Thus, changes in the expression levels of particular genes (e.g., oncogenes or tumor suppressors) serve as signposts for the presence and progression of various diseases.

[0030] Monitoring changes in gene expression may also provide certain advantages during drug screening development. Often drugs are screened and prescreened for the ability to interact with a major target without regard to other effects the drugs have on cells. Often such other effects cause toxicity in the whole animal, which prevent the development and use of the potential drug.

[0031] The present inventors have examined tissue samples from normal liver, metastatic malignant liver and hepatocellular carcinoma to identify the global changes in gene expression associated with liver cancer. The protocol used is schematically represented in FIG. 1. These global changes in gene expression, also referred to as expression profiles, provide useful markers for diagnostic uses as well as markers that can be used to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.

[0032] The present invention provides compositions and methods to detect the level of expression of genes that may be differentially expressed dependent upon the state of the cell, i.e., normal versus cancerous. As used herein, the phrase “detecting the level expression” includes methods that quantitate expression levels as well as methods that determine whether a gene of interest is expressed at all. Thus, an assay which provides a yes or no result without necessarily providing quantification of an amount of expression is an assay that requires “detecting the level of expression” as that phrase is used herein.

Assay Formats

[0033] The genes identified as being differentially expressed in liver cancer may be used in a variety of nucleic acid detection assays to detect or quantititate the expression level of a gene or multiple genes in a given sample. For example, traditional Northern blotting, nuclease protection, RT-PCR and differential display methods may be used for detecting gene expression levels. Those methods are useful for some embodiments of the invention. However, methods and assays of the invention are most efficiently designed with array or chip hybridization-based methods for detecting the expression of a large number of genes.

[0034] Any hybridization assay format may be used, including solution-based and solid support-based assay formats. Solid supports containing oligonucleotide probes for differentially expressed genes of the invention can be filters, polyvinyl chloride dishes, silicon or glass based chips, etc. Such wafers and hybridization methods are widely available, for example, those disclosed by Beattie (WO 95/11755). Any solid surface to which oligonucleotides can be bound, either directly or indirectly, either covalently or non-covalently, can be used. A preferred solid support is a high density array or DNA chip. These contain a particular oligonucleotide probe in a predetermined location on the array. Each predetermined location may contain more than one molecule of the probe, but each molecule within the predetermined location has an identical sequence. Such predetermined locations are termed features. There may be, for example, about 2, 10, 100, 1000 to 10,000; 100,000 or 400,000 of such features on a single solid support. The solid support, or the area within which the probes are attached may be on the order of a square centimeter.

[0035] Oligonucleotide probe arrays for expression monitoring can be made and used according to any techniques known in the art (see for example, Lockhart et al., (1996) Nat. Biotechnol. 14, 1675-1680; McGall et al., (1996) Proc. Nat. Acad. Sci. USA 93, 13555-13460). Such probe arrays may contain at least two or more oligonucleotides that are complementary to or hybridize to two or more of the genes described herein. Such arrays may also contain oligonucleotides that are complementary or hybridize to at least about 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 50, 70, 100 or or more the genes described herein.

[0036] The genes which are assayed according to the present invention are typically in the form of mRNA or reverse transcribed mRNA. The genes may be cloned or not and the genes may be amplified or not. The cloning itself does not appear to bias the representation of genes within a population. However, it may be preferable to use polyA+RNA as a source, as it can be used with less processing steps.

[0037] The sequences of the expression marker genes are in the public databases. Tables 3-9 provide the GenBank accession number for the genes and ESTs identified called either Accession # (Tables 3, 4, and 5) or Fragment Name (Tables 6-9). The sequences of the genes in GenBank are expressly incorporated by reference as are equivalent and related sequences present in GenBank or other public databases. The column labeled “SEQ ID” refers to the sequence identification number correlating the listed gene or EST to its sequence information as provided within the sequence listing of this application.

[0038] Probes based on the sequences of the genes described herein may be prepared by any commonly available method. Oligonucleotide probes for assaying the tissue or cell sample are preferably of sufficient length to specifically hybridize only to appropriate, complementary genes or transcripts. Typically the oligonucleotide probes will be at least 10, 12, 14, 16, 18, 20 or 25 nucleotides in length. In some cases longer probes of at least 30, 40, or 50 nucleotides will be desirable.

[0039] As used herein, oligonucleotide sequences that are complementary to one or more of the genes described herein, refers to oligonucleotides that are capable of hybridizing under stringent conditions to at least part of the nucleotide sequence of said genes. Such hybridizable oligonucleotides will typically exhibit at least about 75% sequence identity at the nucleotide level to said genes, preferably about 80% or 85% sequence identity or more preferably about 90% or 95% or more sequence identity to said genes.

[0040] “Bind(s) substantially” refers to complementary hybridization between a probe nucleic acid and a target nucleic acid and embraces minor mismatches that can be accommodated by reducing the stringency of the hybridization media to achieve the desired detection of the target polynucleotide sequence.

[0041] The terms “background” or “background signal intensity” refer to hybridization signals resulting from non-specific binding, or other interactions, between the labeled target nucleic acids and components of the oligonucleotide array (e.g., the oligonucleotide probes, control probes, the array substrate, etc.). Background signals may also be produced by intrinsic fluorescence of the array components themselves. A single background signal can be calculated for the entire array, or a different background signal may be calculated for each target nucleic acid. In a preferred embodiment, background is calculated as the average hybridization signal intensity for the lowest 5% to 10% of the probes in the array, or, where a different background signal is calculated for each target gene, for the lowest 5% to 10% of the probes for each gene. Of course, one of skill in the art will appreciate that where the probes to a particular gene hybridize well and thus appear to be specifically binding to a target sequence, they should not be used in a background signal calculation. Alternatively, background may be calculated as the average hybridization signal intensity produced by hybridization to probes that are not complementary to any sequence found in the sample (e.g., probes directed to nucleic acids of the opposite sense or to genes not found in the sample such as bacterial genes where the sample is mammalian nucleic acids). Background can also be calculated as the average signal intensity produced by regions of the array that lack any probes at all.

[0042] The phrase “hybridizing specifically to” refers to the binding, duplexing or hybridizing of a molecule substantially to or only to a particular nucleotide sequence or sequences under stringent conditions when that sequence is present in a complex mixture (e.g., total cellular) DNA or RNA.

[0043] Assays and methods of the invention may utilize available formats to simultaneously screen at least about 100, preferably about 1000, more preferably about 10,000 and most preferably about 1,000,000 or more different nucleic acid hybridizations.

[0044] The term “mismatch control” or “mismatch probe” refer to a probe whose sequence is deliberately selected not to be perfectly complementary to a particular target sequence. For each mismatch (MM) control in a high-density array there typically exists a corresponding perfect match (PM) probe that is perfectly complementary to the same particular target sequence. The mismatch may comprise one or more bases.

[0045] While the mismatch(s) may be located anywhere in the mismatch probe, terminal mismatches are less desirable as a terminal mismatch is less likely to prevent hybridization of the target sequence. In a particularly preferred embodiment, the mismatch is located at or near the center of the probe such that the mismatch is most likely to destabilize the duplex with the target sequence under the test hybridization conditions.

[0046] The term “perfect match probe” refers to a probe that has a sequence that is perfectly complementary to a particular target sequence. The test probe is typically perfectly complementary to a portion (subsequence) of the target sequence. The perfect match (PM) probe can be a “test probe”, a “normalization control” probe, an expression level control probe and the like. A perfect match control or perfect match probe is, however, distinguished from a “mismatch control” or “mismatch probe.”

[0047] As used herein a “probe” is defined as a nucleic acid, capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation. As used herein, a probe may include natural (i.e., A, G, U, C or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in probes may be joined by a linkage other than a phosphodiester bond, so long as it does not interfere with hybridization. Thus, probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages.

[0048] The term “stringent conditions” refers to conditions under which a probe will hybridize to its target subsequence, but with only insubstantial hybridization to other sequences or to other sequences such that the difference may be identified. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. Generally, stringent conditions are selected to be about 5° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH.

[0049] Typically, stringent conditions will be those in which the salt concentration is at least about 0.01 to 1.0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes (e.g., 10 to 50 nucleotide). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide.

[0050] The “percentage of sequence identity” or “sequence identity” is determined by comparing two optimally aligned sequences or subsequences over a comparison window or span, wherein the portion of the polynucleotide sequence in the comparison window may optionally comprise additions or deletions (i.e., gaps) as compared to the reference sequence (which does not comprise additions or deletions) for optimal alignment of the two sequences. The percentage is calculated by determining the number of positions at which the identical monomer unit (e.g., nucleic acid base or amino acid residue) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison and multiplying the result by 100 to yield the percentage of sequence identity. Percentage sequence identity when calculated using the programs GAP or BESTFIT (see below) is calculated using default gap weights.

[0051] Homology or identity may be determined by BLAST (Basic Local Alignment Search Tool) analysis using the algorithm employed by the programs blastp, blastn, blastx, tblastn and tblastx (Karlin et al., (1990) Proc. Natl. Acad. Sci. USA 87, 2264-2268 and Altschul, (1993) J. Mol. Evol. 36, 290-300, fully incorporated by reference) which are tailored for sequence similarity searching. The approach used by the BLAST program is to first consider similar segments between a query sequence and a database sequence, then to evaluate the statistical significance of all matches that are identified and finally to summarize only those matches which satisfy a preselected threshold of significance. For a discussion of basic issues in similarity searching of sequence databases, see Altschul et al., (1994) Nature Genet. 6, 119-129) which is filly incorporated by reference. The search parameters for histogram, descriptions, alignments, expect (i.e., the statistical significance threshold for reporting matches against database sequences), cutoff, matrix and filter are at the default settings. The default scoring matrix used by blastp, blastx, tblastn, and tblastx is the BLOSUM62 matrix (Henikoff et al., (1992) Proc. Natl. Acad. Sci. USA 89, 10915-10919, fully incorporated by reference). Four blastn parameters were adjusted as follows: Q=10 (gap creation penalty); R=10 (gap extension penalty); wink=1 (generates word hits at every wink™ position along the query); and gapw=16 (sets the window width within which gapped alignments are generated). The equivalent Blastp parameter settings were Q=9; R=2; wink=1; and gapw=32. A Bestfit comparison between sequences, available in the GCG package version 10.0, uses DNA parameters GAP=50 (gap creation penalty) and LEN=3 (gap extension penalty) and the equivalent settings in protein comparisons are GAP=8 and LEN=2.

Probe Design

[0052] One of skill in the art will appreciate that an enormous number of array designs are suitable for the practice of this invention. The high density array will typically include a number of probes that specifically hybridize to the sequences of interest. See WO 99/32660 for methods of producing probes for a given gene or genes. In addition, in a preferred embodiment, the array will include one or more control probes.

[0053] High density array chips of the invention include “test probes.” Test probes may be oligonucleotides that range from about 5 to about 500 or about 5 to about 50 nucleotides, more preferably from about 10 to about 40 nucleotides and most preferably from about 15 to about 40 nucleotides in length. In other particularly preferred embodiments the probes are about 20 to 25 nucleotides in length. In another preferred embodiment, test probes are double or single strand DNA sequences. DNA sequences are isolated or cloned from natural sources or amplified from natural sources using natural nucleic acid as templates. These probes have sequences complementary to particular subsequences of the genes whose expression they are designed to detect. Thus, the test probes are capable of specifically hybridizing to the target nucleic acid they are to detect.

[0054] In addition to test probes that bind the target nucleic acid(s) of interest, the high density array can contain a number of control probes. The control probes fall into three categories referred to herein as (1) normalization controls; (2) expression level controls; and (3) mismatch controls.

[0055] Normalization controls are oligonucleotide or other nucleic acid probes that are complementary to labeled reference oligonucleotides or other nucleic acid sequences that are added to the nucleic acid sample. The signals obtained from the normalization controls after hybridization provide a control for variations in hybridization conditions, label intensity, “reading” efficiency and other factors that may cause the signal of a perfect hybridization to vary between arrays. In a preferred embodiment, signals (e.g., fluorescence intensity) read from all other probes in the array are divided by the signal (e.g., fluorescence intensity) from the control probes thereby normalizing the measurements.

[0056] Virtually any probe may serve as a normalization control. However, it is recognized that hybridization efficiency varies with base composition and probe length. Preferred normalization probes are selected to reflect the average length of the other probes present in the array, however, they can be selected to cover a range of lengths. The normalization control(s) can also be selected to reflect the (average) base composition of the other probes in the array, however in a preferred embodiment, only one or a few probes are used and they are selected such that they hybridize well (i.e., no secondary structure) and do not match any target-specific probes.

[0057] Expression level controls are probes that hybridize specifically with constitutively expressed genes in the biological sample. Virtually any constitutively expressed gene provides a suitable target for expression level controls. Typical expression level control probes have sequences complementary to subsequences of constitutively expressed “housekeeping genes” including, but not limited to the β-actin gene, the transferrin receptor gene, the GAPDH gene, and the like.

[0058] Mismatch controls may also be provided for the probes to the target genes, for expression level controls or for normalization controls. Mismatch controls are oligonucleotide probes or other nucleic acid probes identical to their corresponding test or control probes except for the presence of one or more mismatched bases. A mismatched base is a base selected so that it is not complementary to the corresponding base in the target sequence to which the probe would otherwise specifically hybridize. One or more mismatches are selected such that under appropriate hybridization conditions (e.g., stringent conditions) the test or control probe would be expected to hybridize with its target sequence, but the mismatch probe would not hybridize (or would hybridize to a significantly lesser extent). Preferred mismatch probes contain a central mismatch. Thus, for example, where a probe is a twenty-mer, a corresponding mismatch probe will have the identical sequence except for a single base mismatch (e.g., substituting a G, a C or a T for an A) at any of positions 6 through 14 (the central mismatch).

[0059] Mismatch probes thus provide a control for non-specific binding or cross hybridization to a nucleic acid in the sample other than the target to which the probe is directed. Mismatch probes also indicate whether a hybridization is specific or not. For example, if the target is present the perfect match probes should be consistently brighter than the mismatch probes. In addition, if all central mismatches are present, the mismatch probes can be used to detect a mutation. The difference in intensity between the perfect match and the mismatch probe (IBM)-I(MM)) provides a good measure of the concentration of the hybridized material.

Nucleic Acid Samples

[0060] As is apparent to one of ordinary skill in the art, nucleic acid samples used in the methods and assays of the invention may be prepared by any available method or process. Methods of isolating total mRNA are also well known to those of skill in the art. For example, methods of isolation and purification of nucleic acids are described in detail in Chapter 3 of Laboratory Techniques in Biochemistry and Molecular Biology: Hybridization With Nucleic Acid Probes, Part I Theory and Nucleic Acid Preparation, Tijssen, (1993) (editor) Elsevier Press. Such samples include RNA samples, but also include cDNA synthesized from a mRNA sample isolated from a cell or tissue of interest. Such samples also include DNA amplified from the cDNA, and an RNA transcribed from the amplified DNA. One of skill in the art would appreciate that it is desirable to inhibit or destroy RNase present in homogenates before homogenates can be used.

[0061] Biological samples may be of any biological tissue or fluid or cells from any organism as well as cells raised in vitro, such as cell lines and tissue culture cells. Frequently the sample will be a “clinical sample” which is a sample derived from a patient. Typical clinical samples include, but are not limited to, sputum, blood, blood-cells (e.g., white cells), tissue or fine needle biopsy samples, urine, peritoneal fluid, and pleural fluid, or cells therefrom.

[0062] Biological samples may also include sections of tissues, such as frozen sections or formalin fixed sections taken for histological purposes.

Forming High Density Arrays.

[0063] Methods of forming high density arrays of oligonucleotides with a minimal number of synthetic steps are known. The oligonucleotide analogue array can be synthesized on a solid substrate by a variety of methods, including, but not limited to, light-directed chemical coupling, and mechanically directed coupling (see Pirrung et al., (1992) U.S. Pat. No. 5,143, 854; Fodor et al., (1998) U.S. Pat. No. 5,800,992; Chee et al, (1998) U.S. Pat. No. 5,837,832

[0064] In brief, the light-directed combinatorial synthesis of oligonucleotide arrays on a glass surface proceeds using automated phosphoramidite chemistry and chip masking techniques. In one specific implementation, a glass surface is derivatized with a silane reagent containing a functional group, e.g., a hydroxyl or amine group blocked by a photolabile protecting group. Photolysis through a photolithogaphic mask is used selectively to expose functional groups which are then ready to react with incoming 5′ photoprotected nucleoside phosphoramidites. The phosphoramidites react only with those sites which are illuminated (and thus exposed by removal of the photolabile blocking group). Thus, the phosphoramidites only add to those areas selectively exposed from the preceding step. These steps are repeated until the desired array of sequences have been synthesized on the solid surface. Combinatorial synthesis of different oligonucleotide analogues at different locations on the array is determined by the pattern of illumination during synthesis and the order of addition of coupling reagents.

[0065] In addition to the foregoing, additional methods which can be used to generate an array of oligonucleotides on a single substrate are described in Fodor et al., (1993). WO 93/09668. High density nucleic acid arrays can also be fabricated by depositing premade or natural nucleic acids in predetermined positions. Synthesized or natural nucleic acids are deposited on specific locations of a substrate by light directed targeting and oligonucleotide directed targeting. Another embodiment uses a dispenser that moves from region to region to deposit nucleic acids in specific spots.

Hybridization

[0066] Nucleic acid hybridization simply involves contacting a probe and target nucleic acid under conditions where the probe and its complementary target can form stable hybrid duplexes through complementary base pairing (see Lockhart et al., (1999) WO 99/32660). The nucleic acids that do not form hybrid duplexes are then washed away leaving the hybridized nucleic acids to be detected, typically through detection of an attached detectable label. It is generally recognized that nucleic acids are denatured by increasing the temperature or decreasing the salt concentration of the buffer containing the nucleic acids.

[0067] Under low stringency conditions (e.g., low temperature and/or high salt) hybrid duplexes (e.g., DNA-DNA, RNA-RNA or RNA-DNA) will form even where the annealed sequences are not perfectly complementary.

[0068] Thus specificity of hybridization is reduced at lower stringency. Conversely, at higher stringency (e.g., higher temperature or lower salt) successful hybridization requires fewer mismatches. One of skill in the art will appreciate that hybridization conditions may be selected to provide any degree of stringency. In a preferred embodiment, hybridization is performed at low stringency, in this case in 6×SSPE-T at 37° C. (0.005% Triton x-100) to ensure hybridization and then subsequent washes are performed at higher stringency (e.g., 1×SSPE-T at 37° C.) to eliminate mismatched hybrid duplexes. Successive washes may be performed at increasingly higher stringency (e.g., down to as low as 0.25×SSPET at 37° C. to 50° C.) until a desired level of hybridization specificity is obtained. Stringency can also be increased by addition of agents such as formamide. Hybridization specificity may be evaluated by comparison of hybridization to the test probes with hybridization to the various controls that can be present (e.g., expression level control, normalization control, mismatch controls, etc.).

[0069] In general, there is a tradeoff between hybridization specificity (stringency) and signal intensity. Thus, in a preferred embodiment, the wash is performed at the highest stringency that produces consistent results and that provides a signal intensity greater than approximately 10% of the background intensity. Thus, in a preferred embodiment, the hybridized array may be washed at successively higher stringency solutions and read between each wash. Analysis of the data sets thus produced will reveal a wash stringency above which the hybridization pattern is not appreciably altered and which provides adequate signal for the particular oligonucleotide probes of interest.

Signal Detection

[0070] The hybridized nucleic acids are typically detected by detecting one or more labels attached to the sample nucleic acids. The labels may be incorporated by any of a number of means well known to those of skill in the art (see Lockhart et al., (1999) WO 99/32660).

Databases

[0071] The present invention includes relational databases containing sequence information, for instance for the genes of Tables 3-9, as well as gene expression information in various liver tissue samples. Databases may also contain information associated with a given sequence or tissue sample such as descriptive information about the gene associated with the sequence information, or descriptive information concerning the clinical status of the tissue sample, or the patient from which the sample was derived. The database may be designed to include different parts, for instance a sequences database and a gene expression database. Methods for the configuration and construction of such databases are widely available, for instance, see Akerblom et al., (1999) U.S. Pat. No. 5,953,727, which is herein incorporated by reference in its entirety.

[0072] The databases of the invention may be linked to an outside or external database. In a preferred embodiment, as described in Tables 3-9, the external database is GenBank and the associated databases maintained by the National Center for Biotechnology Information (NCBI).

[0073] Any appropriate computer platform may be used to perform the necessary comparisons between sequence information, gene expression information and any other information in the database or provided as an input. For example, a large number of computer workstations are available from a variety of manufacturers, such has those available from Silicon Graphics. Client-server environments, database servers and networks are also widely available and appropriate platforms for the databases of the invention.

[0074] The databases of the invention may be used to produce, among other things, electronic Northerns to allow the user to determine the cell type or tissue in which a given gene is expressed and to allow determination of the abundance or expression level of a given gene in a particular tissue or cell.

[0075] The databases of the invention may also be used to present information identifying the expression level in a tissue or cell of a set of genes comprising at least one gene in Tables 3-9 comprising the step of comparing the expression level of at least one gene in Tables 3-9 in the tissue to the level of expression of the gene in the database. Such methods may be used to predict the physiological state of a given tissue by comparing the level of expression of a gene or genes in Tables 3-9 from a sample to the expression levels found in tissue from normal liver, malignant liver or hepatocellular carcinoma. Such methods may also be used in the drug or agent screening assays as described below.

Kits

[0076] The invention further includes kits combining, in different combinations, high-density oligonucleotide arrays, reagents for use with the arrays, signal detection and array-processing instruments, gene expression databases and analysis and database management software described above. The kits may be used, for example, to predict or model the toxic response of a test compound, to monitor the progression of liver disease states, to identify genes that show promise as new drug targets and to screen known and newly designed drugs as discussed above.

[0077] The databases packaged with the kits are a compilation of expression patterns from human or laboratory animal genes and gene fragments (corresponding to the genes of Table 3-9). Data is collected from a repository of both normal and diseased animal tissues and provides reproducible, quantitative results, i.e., the degree to which a gene is up-regulated or down-regulated under a given condition.

[0078] The kits may used in the pharmaceutical industry, where the need for early drug testing is strong due to the high costs associated with drug development, but where bioinformatics, in particular gene expression informatics, is still lacking. These kits will reduce the costs, time and risks associated with traditional new drug screening using cell cultures and laboratory animals. The results of large-scale drug screening of pre-grouped patient populations, pharmacogenomics testing, can also be applied to select drugs with greater efficacy and fewer side-effects. The kits may also be used by smaller biotechnology companies and research institutes who do not have the facilities for performing such large-scale testing themselves.

[0079] Databases and software designed for use with use with microarrays is discussed in Balaban et al., U.S. Pat. No. Nos. 6,229,911, a computer-implemented method for managing information, stored as indexed tables, collected from small or large numbers of microarrays, and U.S. Pat. No. 6,185,561, a computer-based method with data mining capability for collecting gene expression level data, adding additional attributes and reformatting the data to produce answers to various queries. Chee et al., U.S. Pat. No. 5,974,164, disclose a software-based method for identifying mutations in a nucleic acid sequence based on differences in probe fluorescence intensities between wild type and mutant sequences that hybridize to reference sequences.

Diagnostic Uses for the Liver Cancer Markers

[0080] As described above, the genes and gene expression information provided in Tables 3-9 may be used as diagnostic markers for the prediction or identification of the malignant state of the liver tissue. For instance, a liver tissue sample or other sample from a patient may be assayed by any of the methods described above, and the expression levels from a gene or genes from the Tables, in particular the genes in Tables 3-5, may be compared to the expression levels found in normal liver tissue, tissue from metastatic liver cancer or hepatocellular carcinoma tissue. Expression profiles generated from the tissue or other sample that substantially resemble an expression profile from normal or diseased liver tissue may be used, for instance, to aid in disease diagnosis. Comparison of the expression data, as well as available sequence or other information may be done by researcher or diagnostician or may be done with the aid of a computer and databases as described above.

Use of the Liver Cancer Markers for Monitoring Disease Progression

[0081] As described above, the genes and gene expression information provided in Tables 3-9 may also be used as markers for the monitoring of disease progression, for instance, the development of liver cancer. For instance, a liver tissue sample or other sample from a patient may be assayed by any of the methods described above, and the expression levels in the sample from a gene or genes from or 3-9 may be compared to the expression levels found in normal liver tissue, tissue from metastatic liver cancer or hepatocellular carcinoma tissue. Comparison of the expression data, as well as available sequence or other information may be done by researcher or diagnostician or may be done with the aid of a computer and databases as described above.

Use of the Liver Cancer Markers for Drug Screening

[0082] According to the present invention, the genes identified in Tables 3-9 may be used as markers to evaluate the effects of a candidate drug or agent on a cell, particularly a cell undergoing malignant transformation, for instance, a liver cancer cell or tissue sample. A candidate drug or agent can be screened for the ability to simulate the transcription or expression of a given marker or markers (drug targets) or to down-regulate or counteract the transcription or expression of a marker or markers. According to the present invention, one can also compare the specificity of drugs' effects by looking at the number of markers which the drugs have and comparing them. More specific drugs will have fewer transcriptional targets. Similar sets of markers identified for two drugs indicates a similarity of effects.

[0083] Assays to monitor the expression of a marker or markers as defined in Tables 3-9 may utilize any available means of monitoring for changes in the expression level of the nucleic acids of the invention. As used herein, an agent is said to modulate the expression of a nucleic acid of the invention if it is capable of up- or down-regulating expression of the nucleic acid in a cell.

[0084] In one assay format, gene chips containing probes to at least two genes from Tables 3-9 may be used to directly monitor or detect changes in gene expression in the treated or exposed cell as described in more detail above. In another format, cell lines that contain reporter gene fusions between the open reading frame and/or the 3′ or 5′ regulatory regions of a gene in Tables 3-9 and any assayable fusion partner may be prepared. Numerous assayable fusion partners are known and readily available including the firefly luciferase gene and the gene encoding chloramphenicol acetyltransferase (Alam et al., (1990) Anal. Biochem. 188, 245-254). Cell lines containing the reporter gene fusions are then exposed to the agent to be tested under appropriate conditions and time. Differential expression of the reporter gene between samples exposed to the agent and control samples identifies agents which modulate the expression of the nucleic acid.

[0085] Additional assay formats may be used to monitor the ability of the agent to modulate the expression of a gene identified in Tables 3-9. For instance, as described above, mRNA expression may be monitored directly by hybridization of probes to the nucleic acids of the invention. Cell lines are exposed to the agent to be tested under appropriate conditions and time and total RNA or mRNA is isolated by standard procedures such those disclosed in Sambrook et al., (1989) Molecular Cloning—A Laboratory Manual, Cold Spring Harbor Laboratory Press).

[0086] In another assay format, cells or cell lines are first identified which express the gene products of the invention physiologically. Cell and/or cell lines so identified would be expected to comprise the necessary cellular machinery such that the fidelity of modulation of the transcriptional apparatus is maintained with regard to exogenous contact of agent with appropriate surface transduction mechanisms and/or the cytosolic cascades. Such cell lines may be, but are not required to be, derived from liver tissue. Further, such cells or cell lines may be transduced or transfected with an expression vehicle (e.g., a plasmid or viral vector) construct comprising an operable non-translated 5′-promoter containing end of the structural gene encoding the instant gene products fused to one or more antigenic fragments, which are peculiar to the instant gene products, wherein said fragments are under the transcriptional control of said promoter and are expressed as polypeptides whose molecular weight can be distinguished from the naturally occurring polypeptides or may further comprise an immunologically distinct tag. Such a process is well known in the art (see Sambrook et al., (1989) Molecular Cloning—A Laboratory Manual, Cold Spring Harbor Laboratory Press).

[0087] Cells or cell lines transduced or transfected as outlined above are then contacted with agents under appropriate conditions; for example, the agent comprises a pharmaceutically acceptable excipient and is contacted with cells comprised in an aqueous physiological buffer such as phosphate buffered saline (PBS) at physiological pH, Eagles balanced salt solution (BSS) at physiological pH, PBS or BSS comprising serum or conditioned media comprising PBS or BSS and serum incubated at 37° C. Said conditions may be modulated as deemed necessary by one of skill in the art. Subsequent to contacting the cells with the agent, said cells will be disrupted and the polypeptides of the lysate are fractionated such that a polypeptide fraction is pooled and contacted with an antibody to be further processed by immunological assay (e.g., ELISA, immunoprecipitation or Western blot). The pool of proteins isolated from the “agent-contacted” sample will be compared with a control sample where only the excipient is contacted with the cells and an increase or decrease in the immunologically generated signal from the “agent-contacted” sample compared to the control will be used to distinguish the effectiveness of the agent.

[0088] Another embodiment of the present invention provides methods for identifying agents that modulate the levels, concentration or at least one activity of a protein(s) encoded by the genes in Tables 3-9. Such methods or assays may utilize any means of monitoring or detecting the desired activity.

[0089] In one format, the relative amounts of a protein of the invention between a cell population that has been exposed to the agent to be tested compared to an unexposed control cell population may be assayed. In this format, probes such as specific antibodies are used to monitor the differential expression of the protein in the different cell populations. Cell lines or populations are exposed to the agent to be tested under appropriate conditions and time. Cellular lysates may be prepared from the exposed cell line or population and a control, unexposed cell line or population. The cellular lysates are then analyzed with the probe, such as a specific antibody.

[0090] Agents that are assayed in the above methods can be randomly selected or rationally selected or designed. As used herein, an agent is said to be randomly selected when the agent is chosen randomly without considering the specific sequences involved in the association of the a protein of the invention alone or with its associated substrates, binding partners, etc. An example of randomly selected agents is the use a chemical library or a peptide combinatorial library, or a growth broth of an organism.

[0091] As used herein, an agent is said to be rationally selected or designed when the agent is chosen on a nonrandom basis which takes into account the sequence of the target site and/or its conformation in connection with the agents action. Agents can be rationally selected or rationally designed by utilizing the peptide sequences that make up these sites.

[0092] For example, a rationally selected peptide agent can be a peptide whose amino acid sequence is identical to or a derivative of any functional consensus site.

[0093] The agents of the present invention can be, as examples, peptides, small molecules, vitamin derivatives, as well as carbohydrates. Dominant negative proteins, DNA encoding these proteins, antibodies to these proteins, peptide fragments of these proteins or mimics of these proteins may be introduced into cells to affect function. “Mimic” as used herein refers to the modification of a region or several regions of a peptide molecule to provide a structure chemically different from the parent peptide but topographically and functionally similar to the parent peptide (see Grant, (1995) in Molecular Biology and Biotechnology Meyers (editor) VCH Publishers). A skilled artisan can readily recognize that there is no limit as to the structural nature of the agents of the present invention.

[0094] Without further description, it is believed that one of ordinary skill in the art can, using the preceding description and the following illustrative examples, make and utilize the compounds of the present invention and practice the claimed methods. The following working examples therefore, specifically point out the preferred embodiments of the present invention, and are not to be construed as limiting in any way the remainder of the disclosure.

EXAMPLES

Example 1

Tissue Sample Acquisition and Preparation

[0095]
FIG. 1 outlines the experimental protocol used. Liver tissue samples were excised and snap frozen in liquid nitrogen. The clinical data for each of the samples included in this study are outlined in Table 1. The sample set was composed of eight samples of normal liver tissue (N1-N8), five samples of metastatic adenocarcinoma arising from rectum (designated M1 and M3) and colon (M2, M4 and M5) tissues and six samples of primary hepatocellular carcinomas. Samples were named according to type of tissue: HCC=hepatocellular carcinoma, M=metastatic, N=normal. Table 1 include the TNM classification (the American Joint Committee on Cancer's system of classifying cancers) of the tissues used as samples where T refers to the extent of the primary tumor, N refers to the absence or presence and extent of regional lymph node metastasis, and M refers to the absence or presence of distant metastasis. Numbers following T, N, and M refer to the size of the primary tumor and the amount of vascular invasion, where 0=no evidence of tumor, lymph node involvement or metastasis, 4=multiple tumors involved, and x=cannot be assessed. Histopathologic grade (Table 1) is a qualitative assessment of differentiation of a tumor, where G1=most differentiated and G4=undifferentiated. Clinical stage (Table 1) characterizes the anatomic extent of disease in the patient from whom the sample was taken, where I and II are early stages, III and IV are late stages.

[0096] With minor modifications, the sample preparation protocol followed the Affymetrix GeneChip Expression Analysis Manual. Frozen tissue was first ground to powder using the Spex Certiprep 6800 Freezer Mill. Total RNA was then extracted using Trizol (Life Technologies). The total RNA yield for each sample (average tissue weight of 300 mg) was 200-500 μg. Next, mRNA was isolated using the Oligotex mRNA Midi kit (Qiagen). Since the mRNA was eluted in a final volume of 400 μl, an ethanol precipitation step was required to bring the concentration to 1 μg/μl. Using 1-5 μg of mRNA, double stranded cDNA was created using the SuperScript Choice system (Gibco-BRL). First strand cDNA synthesis was primed with a T7-(dT24) oligonucleotide. The cDNA was then phenol-chloroform extracted and ethanol precipitated to a final concentration of 1 μg/μl.

[0097] From 2 μg of cDNA, cRNA was synthesized according to standard procedures. To biotin label the cRNA, nucleotides Bio-11 -CTP and Bio-16-UTP (Enzo Diagnostics) were added to the reaction. After a 37° C. incubation for six hours, the labeled cRNA was cleaned up according to the Rneasy Mini kit protocol (Qiagen). The cRNA was then fragmented (5×fragmentation buffer: 200 mM Tris-Acetate (pH 8.1), 500 mM KOAc, 150 mM MgOAc) for thirty-five minutes at 94° C. 55 μg of fragmented cRNA was hybridized on the human Hu35 k set and the HuGeneFL array for twenty-four hours at 60 rpm in a 45° C. hybridization oven The chips were washed and stained with Streptavidin Phycoerythrin (SAPE) (Molecular Probes) in Affymetrix fluidics stations. To amplify staining, SAPE solution was added twice with an anti-streptavidin biotinylated antibody (Vector Laboratories) staining step in between. Hybridization to the probe arrays was detected by fluorometric scanning (Hewlett Packard Gene Array Scanner). Following hybridization and scanning, the microarray images were analyzed for quality control, looking for major chip defects or abnormalities in hybridization signal. After all chips passed QC, the data was analyzed using Affymetrix GeneChip software (v3.0), and Experimental Data Mining Tool (EDMT) software (v1.0).

Example 2

Gene Expression Analysis

[0098] All samples were prepared as described and hybridized onto the Affymetrix HuGeneFL array and the Human Hu35k set of arrays. Each chip contains 16-20 oligonucleotide probe pairs per gene or cDNA clone. These probe pairs include perfectly matched sets and mismatched sets, both of which are necessary for the calculation of the average difference. The average difference is a measure of the intensity difference for each probe pair, calculated by subtracting the intensity of the mismatch from the intensity of the perfect match. This takes into consideration variability in hybridization among probe pairs and other hybridization artifacts that could affect the fluorescence intensities. Using the average difference value that has been calculated, the GeneChip software then makes an absolute call for each gene or EST.

[0099] The absolute call of present, absent or marginal is used to generate a Gene Signature, a tool used to identify those genes that are commonly present or commonly absent in a given sample set, according to the absolute call. For each set of samples, a median average difference was figured using the average differences of each individual sample within the set. The median average difference must be greater than 150 to assure that the expression level is well above the background noise of the hybridization. For the purposes of this study, only the genes and ESTs with a median average difference greater than 150 have been further studied in detail.

[0100] The Gene Signature for one set of samples is compared to the Gene Signature of another set of samples to determine the Gene Signature Differential. This comparison identifies the genes that are consistently present in one set of samples and consistently absent in the second set of samples.

[0101] The Gene Signature Curve is a graphic view of the number of genes consistently present in a given set of samples as the sample size increases, taking into account the genes commonly expressed among a particular set of samples, and discounting those genes whose expression is variable among those samples. The curve is also indicative of the number of samples necessary to generate an accurate Gene Signature. As the sample number increases, the number of genes common to the sample set decreases. The curve is generated using the positive Gene Signatures of the samples in question, determined by adding one sample at a time to the Gene Signature, beginning with the sample with the smallest number of present genes and adding samples in ascending order. The curve displays the sample size required for the most consistency and the least amount of expression variability from sample to sample. The point where this curve begins to level off represents the minimum number of samples required for the Gene Signature. Graphed on the x-axis is the number of samples in the set, and on the y-axis is the number of genes in the positive Gene Signature.

Example 3

Gene Expression Analysis of Normal Liver Tissue

[0102] The gene expression patterns and Gene Signature were individually determined for each sample set: eight samples with normal liver pathology, six samples whose pathology indicated the primary malignancy to be hepatocellular carcinoma, and five samples whose primary colorectal adenocarcinoma had metastasized to the liver. The Gene Signatures obtained for the sample set are shown in FIG. 2

[0103] The Gene Signature considers the present and absent genes alone, and does not take into consideration those that have been called marginal. Table 2 shows the numbers of present genes, called the positive Gene Signature, and the number of absent genes, called the negative Gene Signature, for each of the three sets of samples.

[0104] The Gene Signature is the set of genes that are commonly present or commonly absent in N-1 samples of a given sample set. The positive Gene Signature for the normal liver tissues contains 6,213 genes and ESTs. This same set of normal samples did not show any detectable level of expression of 24,900 genes. Many of the genes and ESTs in this positive Gene Signature are housekeeping genes or structural genes that are not only expressed in the liver, but are ubiquitously expressed in tissues throughout the body. Within this positive Gene Signature are also those genes whose expression is specifically restricted to normal liver tissue and those genes required for the liver to function at its normal capacities. It is the group of genes unique to the liver whose expression levels are most likely to change during tumorigenesis. Whether up-regulated or down-regulated or turned completely on or turned completely off, the changes in expression of these vital genes very likely contributes to the drastic changes in liver function caused by the transformation of normal liver cells into cancerous cells.

Example 4

Gene Expression Analysis of Malignant Liver Tissue

[0105] There are 8,479 genes and ESTs in the positive Gene Signature for the HCC tumors, and a total of 23,233 genes and ESTs are included in the negative Gene Signature of the HCC samples. This negative Gene Signature includes all the genes that have been completely turned off during tumorigenesis, as well as those genes that are not usually expressed in liver tissue. These results include a number of genes and ESTs that are not regularly expressed in liver tissues, but through the process of tumor production, their expression patterns have been dramatically altered from no detectable level of expression to some significant level of expression in comparison with the normal liver.

[0106] The colorectal metastases in the liver commonly express 5,102 genes and ESTs, and do not show expression of 30,455 additional genes and ESTs. As with the negative Gene Signature for the HCC sample set, the genes included in this data set are generally not expressed in liver tissue, whether tumor or normal tissue. The 5,102 in the sample set of metastatic tumors also identify those genes with expression levels that have been changed from off to on as a result of tumor formation.

Example 5

Analysis of Gene Expression Profiles

[0107] A differential comparison of the genes and ESTs expressed in the normals and the two different types of liver tumors identifies a subset of the genes included in the positive Gene Signatures that are uniquely expressed in each sample set. This Gene Signature Differential highlights genes whose expression profiles have most dramatically changed in the transformation from normal to diseased liver cells. The parameters for these analyses were set to accommodate variation in expression of one eight normal samples and one of the six HCC samples or one of the 5 metastatic tumor samples, such that the genes categorized as unique to normal were called present by the software in seven of eight (87%) normal liver samples and were also called absent in five of six HCC (83%) or four of five (80%) metastatic liver tumor. Conversely, the genes categorized as unique to each set of tumors as compared to the normal livers were called present in five of six HCC (83%) or four of five (80%) metastatic tumor samples and absent in seven of eight normal livers (87%).

[0108] The Gene Signature Differential comparing the normal livers to those with metastatic tumors identified a total of 903 sequences expressed only in normal liver tissue. The number of genes or ESTs that meet the median average difference minimum of 150 is 449, of which 289 are genes and the number of ESTs is 160. The remaining ESTs and genes may be indistinguishable from the background noise of the hybridization. The same comparison of normals versus metastatic tumors demonstrates that in the metastatic tumor samples there are 296 uniquely expressed sequences. Those that meet the median average difference minimum requirement are 83 genes and 72 ESTs. Those genes and ESTs expressed in metastatic and not in normal liver tissue are shown in Table 9A and those present in normal liver tissue and not metastatic tissue Table 9B. Numerous genes with differing expression levels in metastatic liver tumor tissue compared to normal tissue were identified. The fifteen genes whose expression level was most different in metastatic as compared to normal tissue are shown in Table 4. Those with the most increased expression are in Table 4A and those with the most decreased expression are in Table 4B. Expression levels were determined by comparing the mean expression values of individual genes in tumor and normal liver samples. Fold change was calculated as a ratio with a p value given as a measure of statistical significance. Fold change is considered significant for a given gene or EST when it is greater than 3.0 with a p value <0.05. Only the characterized genes have been listed; the ESTs with similar fold changes are not presented here. Asterisk (*) in Table 4 denotes those genes that were also identified in the Gene Signature differential between metastatic liver carcinoma and normal liver tissue. A complete listing of all the genes and ESTs with at least a three-fold change in expression is shown in Table 6. Table 6A contains those genes and ESTs whose expression level increased in metastatic tissue relative to normal tissue and Table 6B contains those genes and ESTs whose expression level decreased.

[0109] The Gene Signature Differential between the normal liver samples and the HCC samples identifies a total of 47 unique expressers in the normals, 23 with an median average difference of 150 ,13 of which are named gene and 10 of which are ESTs. When comparing the expression of the HCC samples with the normal livers, there are 243 genes and ESTs only expressed in the HCC samples.

[0110] Those genes and ESTs expressed in HCC and not in normal liver tissue are shown in Table 8A and those present in normal liver tissue and not HCC are shown in Table 8B. Numerous genes with differing expression levels in HCC compared to normal tissue were identified. The fifteen genes whose expression level was most different in HCC as compared to normal tissue are shown in Table 3. Those with the most increased expression are in Table 3A and those with the most decreased expression are in Table 3B. Expression levels were determined by comparing the mean expression values of individual genes in tumor and normal liver samples. Fold change was calculated as a ratio with a p value given as a measure of statistical significance. Fold change is considered significant for a given gene or EST when it is greater than 3.0 with a p value<0.05. Only the characterized genes have been listed; the ESTs with similar fold changes are not presented here. Asterisk (*) in Table 3 denotes those genes that were also identified in the Gene Signature differential between hepatocellular carcinoma and normal liver tissue. A complete listing of all the genes and ESTs with at least a three-fold change in expression is shown in Table 7. Table 7A contains those genes and ESTs whose expression level increased in hepatocellular carcinoma tissue relative to normal tissue and Table 7B contains those genes and ESTs whose expression level decreased.

[0111] Analysis of sample set identified 24 ESTs and 42 genes that are expressed in both metastatic liver tumors and hepatocellular carcinomas, but not in normal liver tissues. The fifteen genes with the most increase in expression level in both types of cancer are shown in Table 5. Expression levels were determined by comparing the mean expression values of individual genes in tumor and normal liver samples. The mean expression value for HCC and metastatic carcinomas was greater than 250, and included only those genes that showed a fold change greater than 3 with significant p values for both sets of tumors. No detectable level of expression was found in the normal liver tissues for these genes. Only the characterized genes have been listed; the ESTs with similar fold changes that are unique to the tumors are not presented here.

[0112] Differential gene expression patterns between normal liver samples and hepatocellular carcinomas and between normal livers and metastatic liver tumors were examined. Genes uniquely expressed by each of the groups individually were identified, as well as those genes that are commonly expressed among liver tumors, whether primary hepatocellular carcinomas or metastatic liver tumors.

Example 6

Association of Liver Cancer with Specific Gene Expression

[0113] The present inventors have closely examined a number of the tumor-expressing genes to determine if their expression patterns correlate with previous reports published in the literature, and to define a logical relationship between the gene and hepatocarcinogenesis. A number of genes that have previously been associated with either liver cancer or other types of cancers were identified, as well as numerous genes that have not been linked to cancers in any previous studies.

[0114] 842 genes and ESTs that are up-regulated in hepatocellular carcinomas were identified when compared with normal liver tissue. One such gene is PTTG1, pituitary tumor-transforming gene 1, or securin, an oncogene that inhibits sister chromatid separation during anaphase. Normal tissues show little or no PTTG1 expression, but high levels of expression have been associated with various tumors, including liver tumors, and carcinoma cell lines. Overexpression in NIH3T3 cells resulted in transformation, and these cells caused the formation of tumors when injected into mice. The mechanism by which this tumorigenic activity takes place is postulated to be through the missegregation of sister chromatids, resulting in aneuploidy and, therefore, genetic instability. Our data further support this overexpression of PTTG1 in hepatocellular carcinoma, with a fold change of 10.7 (P=0.00052), and no detectable level of expression in normal tissues, as identified by the differential comparison of the consensus patterns of gene expression of these two sample sets.

[0115] Galectin 3, LGALS3, one of a family of beta-galactoside-binding animal lectins, is significantly overexpressed both in primary hepatocellular carcinoma and metastatic liver carcinomas with fold changes of 6.8 (P=0.00103) and 27.1 (P=0.00001), respectively. Expression of LGALS3 has been associated with tumor growth, progression, and metastasis, as well as cell-cell and cell-matrix interactions and inflammatory processes. Although expression studies have revealed no detectable level of galectin-3 in normal liver cells, samples from patients with hepatocellular carcinoma revealed considerable levels of LGALS3 expression. The abnormal expression of this lectin may be an early event in the process of transformation of normal cells to tumor cells, or it may impart an increased capacity for these tumor cells to survive and proliferate. Consistent with the reports in the art, an increased expression level was found in both types of tumor, but higher concentrations of galectin-3 were observed in liver metastates from colorectal tumors than in the primary HCC tumors.

[0116] Another gene that is overexpressed in both hepatocellular carcinoma and metastatic colorectal adenocarcinomas with fold changes of 12.2 (P=0.00169) and 58.0 (P=0.00063), respectively, is solute carrier family 2, member 3, or glucose transporter 3 (GLUT3). It is one of a family of transmembrane proteins that function as facilitative glucose transporters, which has a unique specificity for brain and neuronal tissues. Glucose uptake and metabolism are known to be increased in carcinoma cells compared to normal cells. Glucose transporter expression may be elevated in response to the increase in glucose utilization seen in actively proliferating cells, like those of tumors. Conversely, the high levels of glucose transporter expression may be responsible for the enhanced influx of glucose into the tumor cells. Various reports have indicated increased expression of one or more of the family of glucose transporters in malignancies, including those of the brain, esophagus, colon, pancreas, liver, breast, lung, bladder, ovary, testis, skin, head and neck, kidney, and gastric tumors. It has been reported that metastatic liver carcinomas have even higher levels of GLUT3 expression than primary tumors. Consistent with previous studies, the current data confirm the significant overexpression of GLUT3 both in primary liver cancer, hepatocellular carcinoma, and in tumors that have metastasized from the colon and rectum.

[0117] One of the significantly underexpressed genes identified by comparing the expression profiles of hepatocellular carcinomas and metastatic liver tumors with that of normal liver tissue is metallothionein 1L. The expression level in HCC is 26.9 fold lower than that of normal (P=0.00999), and in metastatic colorectal adenocarcinomas it is down-regulated 66.5 fold (P=0.00415). Metallothioneins are heavy metal binding proteins that are involved in detoxification of metals, zinc and copper metabolism cellular adaptation mechanisms, and may be involved in regulating apoptosis. Colorectal adenocarcinoma that has metastasized to the liver has been specifically reported to express less metallothionein than normal liver tissue. Comparison of the consensus patterns of gene expression between metastatic liver samples and normal liver samples show no significant level of MT1L expression in the tumors. Furthermore, additional work has determined that human hepatocellular carcinomas contain much lower levels of metallothioneins than normal liver tissue, and that this decrease correlates with the degree of differentiation and concentrations of copper and zinc in the cells. By comparing the expression profiles of hepatocellular carcinoma and normal liver tissue, this significant reduction in MT1L expression in HCC was confirmed.

[0118] A number of enzymes belonging to the family of cytochrome P450s are drastically underexpressed in the two sets of liver tumors in comparison with the normal liver tissue.

[0119] For example, expression of CYP2A6 is decreased in HCC with a fold change of 14.2 (P=0.0307), and in metastatic tumors with a fold change of 69.9 (P=O). CYP8B 1 is down-regulated 19.3 fold (P=0.00807) in HCC and 65.1 fold (P=0.0039) in liver metastases. In addition to these commonly down-regulated cytochrome P450s, in HCC samples CYP2B is underexpressed 17.9 fold (P=0.01469), and in the metastatic liver tumors CYP2C9 and CYP2A7 are underexpressed 84.7 fold (P=0.00327) and 72.0 fold (P=0), respectively. Several of these genes are also identified by the differential comparison between expression profiles of tumor and normal, confirming the significant decrease in expression in tumor tissues. Many of these P450 enzymes are critical players in the metabolism of carcinogens, drugs, and other chemical compounds, that are expressed in normal liver.

[0120] In addition to genes that are underexpressed in metastatic adenocarcinomas in the liver, more than 1000 genes and ESTs that are overexpressed specifically in these tumors were identified. Two of the most highly up-regulated are claudin 4, also known as clostridium perfringens enterotoxin receptor 1 (fold change 84.4, P=0) and occludin (fold change 43.1, P=0). Both of these genes are tight junction proteins, responsible for the formation and maintenance of continuous seals around epithelial cells to form a physical barrier that blocks the free passage of water and solutes through the paracellular space. More specifically, claudin-4 is one member of a family of transmembrane proteins that comprise tight junction strands, and occludin is a cell adhesion molecule. Claudins likely function as paracellular channels, regulating the flow of ions and solutes into and out of the paracellular space. Tight junction proteins also contribute to the regulation of the cellular processes of cell growth and differentiation. Permeability of tight junctions has been associated with tumor formation, where a breakdown in the barrier function of tight junctions allows an increase in the cellular permeability. This breakdown then opens the tight junction barrier, permitting invasion by tumor cells. It has been reported that tight junctions of colon tumors leak more than do the tight junctions of normal colon. A complete loss of tight junction function and a loss of cell-cell contact growth control has been seen in cells that had been transfected with oncogenic Raf-1, and expression levels of occludin and another claudin are lower in these cells. Occludin expression has been up-regulated in vitro by the addition of various fatty acids that have anti-cancer effects, decreasing the paracellular permeability. The extreme down-regulation of occludin and claudin-4 in metastatic liver tumors is strongly supported by the reports of tight junction breakdown in tumor tissues.

[0121] The present study identified 93 significantly up-regulated genes in both primary HCC and metastatic liver tumors that were not found to have any detectable level of expression in the normal samples. Serine protease inhibitor, Kazal type I (SPINK1), also called pancreatic secretory trypsin inhibitor (PSTI) or tumor-associated trypsin inhibitor (TATI), is one such gene. It is highly expressed in the cells of normal pancreas and in the mucosa of the gastrointestinal tract where it offers protection from proteolytic breakdown. A marked increase in expression is seen in various pancreatic diseases and in tumors of different tissues, including gastric carcinomas, colorectal cancers, and other neoplastic tissues. This increase is presumably due to the elevated expression of trypsin in the tumors, and not related to amplification or rearrangements within the gene. SPINK1 is also considered a valuable marker for a number of solid tumors. An elevation of SPINK1 in the blood of patients with hepatocellular carcinoma has been seen. Furthermore, they suggest that the level of expression correlates with the extent of tumor, such that this heightened expression level could be indicative of HCC under certain conditions. In keeping with this report of overexpression in these tumors, the present expression data show the levels of expression of this gene in HCC samples to be 28.9 times higher than normal (P=0.00003), and in metastatic liver tumors the expression level is 9.8 times higher than normal (P=0.03697).

[0122] Midkine is one of a family of heparin-binding growth factors, inducible by retinoic acid, and is actively involved in cell-cell interactions and angiogenesis. The expression pattern of midkine is highly restricted in normal adult tissues, and no expression has been reported in normal adult liver, although its expression is required during embryogenesis for normal development. However, it is expressed in moderate to high levels in many tumors, including Wilm's tumors of the kidney, stomach, colon, pancreas, lung, esophagus, breast, and liver tumors. The present data confirm these reports, showing a significant overexpression of midkine in hepatocellular carcinoma samples (fold change 9.9, P=0.02104) and in liver metastases (fold change 10.4, P=0.01818), but no noticeable expression in normal liver.

[0123] Stathmin, leukemia-associated phosphoprotein 18, is a phosphoprotein whose expression pattern and phosphorylation status are controlled by extracellular signals responsible for the regulation of the processes of cell proliferation and differentiation. It is also involved in the regulation of cell division via the destabilization of microtubules. When comparing expression levels between non-malignant tissues and malignant tissues, the tumors generally show a significant up-regulation of this phosphoprotein, specifically lymphomas, leukemias, breast and prostate tumors. One reason proposed for this elevated expression in cancer cells is the dissimilarity in the rates of cell proliferation and states of differentiation between normal and tumor cells. In both HCC samples and metastatic adenocarcinomas, significant up-regulation of stathmin, 9.4 fold in HCC (P=0.00015) and 4.8 fold in metastatic tumors (P=0.005 14) was seen.

[0124] Both the genes and ESTs described here will provide valuable information for the identification of new drug targets against liver carcinomas, and that information may be extended for use in the study of carcinogenesis in other tissues. These sequences may be used in the methods of the invention or may be used to produce the probes and arrays of the invention.

[0125] Although the present invention has been described in detail with reference to examples above, it is understood that various modifications can be made without departing from the spirit of the invention. Accordingly, the invention is limited only by the following claims. All cited patents, applications and publications referred to in this application are herein incorporated by reference in their entirety.

1TABLE 1Clinical Information for Hepatocellular Carcinoma, MetastaticLiver Tumor, and Normal Liver Samples Included in this StudyTNMHistopathologicSamplePathologyPrimary TumorAgeGenderRaceClassificationGradeClinical StageHCC1Hepatocellular CarcinomaLiver64MaleCaucasianT3,Nx,MxG2stage IIIHCC2Hepatocellular CarcinomaLiver27FemaleCaucasianT3, N0, MxG1stage IIIHCC3Hepatocellular CarcinomaLiver78FemaleCaucasianT4, Nx, MxG2stage IIIHCC4Hepatocellular CarcinomaLiver43MaleAsianT4, N1, MxG2stage IVHCC5Hepatocellular CarcinomaLiver51MaleCaucasianT4, N0, MxG2stage IVHCC6Hepatocellular CarcinomaLiver57MaleCaucasianunavailableG2stage IIIM1Metastatic AdenocarcinomaRectum61FemaleCaucasianTx, Nx, M1G3stage IV; Duke DM2Metastatic AdenocarcinomaColon54MaleCaucasianunavailableG2stage IV; Duke DM3Metastatic AdenocarcinomaRectum50FemaleCaucasianTx, Nx, M1G2stage IV; Duke DM4Metastatic AdenocarcinomaColon60MaleCaucasianTx, Nx, M1G2stage IV; Duke DM5Metastatic AdenocarcinomaColon57MaleCaucasianTx, Nx, M1G2stage IV; Duke DN1Normal liver54FemaleCaucasianN2Normal liver55FemaleCaucasianN3Normal liver58MaleCaucasianN4Normal liver44FemaleCaucasianN5Normal liver40FemaleCaucasianN6Normal liver72FemaleCaucasianN7Normal liver48FemaleUnknownN8Normal liver55FemaleCaucasian

[0126]

2

TABLE 2

Summary of Genes and ESTs Expressed in HCC, Metastatic Liver Tumors, and Normal Livers

Hepatocelluar
Colorectal

Carcinoma
Metastases
Normal Livers

I. Fingerprint of Gene Expression

Genes and ESTs commonly expressed in sample set
8479
5102
6213

Genes and ESTs commonly unexpressed in sample set
23233
30455
24900

II. Fold Change

Genes and ESTs overexpressed in tumors (fold change >3 and p < 0.05)
842
1044

Number of Genes
430
603

Number of ESTs
412
441

Genes and ESTs underexpressed in tumors (fold change >3 and p < 0.05)
393
1867

Number of Genes
235
1016

Number of ESTs
158
851

III. Differential Comparison between Normal and Tumor Expression

Genes and ESTs turned ON in tumors
243
296

Genes and ESTs with expression level above threshold in tumor
77
155

Number of Genes
38
83

Number of ESTs
39
72

Genes and ESTs turned OFF in tumors
47
903

Genes and ESTs with expression level above threshold in normal
23
449

Number of Genes
13
289

Number of ESTs
10
160

[0127]

3

Table 3A

Top Fifteen Genes Overexpressed in Hepatocellular Carcinoma

Unigene

Fold

Accession #
SEQ ID:
Cluster
Gene Name
Change
Pvalue

N33920
2492
Hs.44532
diubiquitin
50.3
0

Y00705
3847
Hs.181286
serine protease inhibitor, Kazal type 1
28.9
0.00003

AA610116
1499
Hs.102737
tetraspan NET-6 protein
16.4
0.00249

AA505133
1417
Hs.279905
solute carrier family 2 (facilitated glucose transporter),
12.2
0.00169

member 3

AA055896
135
Hs.146428
collagen, type V, alpha 1
10.9*
0.00907

AA430032
1009
Hs.252587
pituitary tumor-transforming 1
10.7*
0.00052

Z37987
3879
Hs.119651
glypican 3
10.7
0.02304

J03464
2094
Hs.179573
collagen, type I, alpha 2
10.4
0.00979

W45320
3520
Hs.228059
KRAB-associated protein 1
10.1*
0.00002

M94250
2425
Hs.82045
midkine (neurite growth-promoting factor 2)
9.9*
0.02104

AA428172
986
Hs.8546
Notch (Drosophila) homolog 3
9.6*
0.00195

AA620881
1510
Hs.21858
trinucleotide repeat containing 3
9.5
0.00062

D51276
1678
Hs.81915
leukemia-associated phosphoprotein p18 (stathmin)
9.4
0.00015

AA156187
399
Hs.81634
ATP synthase, H+ transporting, mitochondrial F0 complex
9.4
0.02007

subunit b, isoform 1

D31094
1639
Hs.109798
G8 protein
9.4
0.0048

[0128]

4

TABLE 3B

Top Fifteen Genes that are Underexpressed in Hepatocellular Carcinoma

Unique

Fold

Accession #
SEQ ID:
Cluster
Gene Name
Change
Pvalue

HB1070
2006
Hs.8765
RNA helicase-related protein
39.6
0.00002

AA007395
17
Hs.1219
alcohol dehydrogenase 4 (class II), pi polypeptide
37.8
0.00939

T48075
3129
Hs.251577
hemoglobin, alpha 1
35.8
0.00471

N80129
2702
Hs.94360
metallothionein 1 L
26.9
0.00999

AA010605
26
Hs.2899
4-hydroxyphenylpyruvate dioxygenase
25.5
0.00855

W88946
3636
Hs.18508
putative glycine-N-acyltransferase
25.3
0.00221

T95813
3261
Hs.137476
KIAA1051 protien
20.4
0.01361

H58692
1960
Hs.9520
formyltetrahydrofolate dehydrogenase
20.2
0.00485

R97419
3003
Hs.35718
cyctochrome P450, subfamily VIIIB (sterol 12-alpha-
19.3
0.00807

hydroxylase), polypeptide 1

H80901
2005
Hs.272576
ficolin (collagen/fibrinogen domain-containing) 3 (Hakata
18.6
0

antigen)

M29873
2318
Hs.1360
cytochrome P450, subfamily IIB (phenobarbital-inducible)
17.9
0.01469

U56814
3392
Hs.88646
deoxyribonuclease I-like 3
17.7
0.00007

T67931
3183
Hs.7645
fibrinogen, B beta polypeptide
17.3
0.00128

K03192
2127
Hs/183584
cytochrome P450, subfamily IIA (phenobarbital-inducible),
14.2
0.0307

polypeptide 6

AA448002
1113
Hs.23759
putative type II membrane protein
14.1*
0

[0129]

5

TABLE 4A

Top Fifteen Genes Overexpressed in Metastatic Carcinomas in the Liver

Unigene

Fold

Accession #
SEQ ID:
Cluster
Gene Name
Change
Pvalue

AA427468
973
Hs.5372
Claudin 4
84.4*
0

H58873
1961
Hs.169902
Solute carrier family 2 (facilitated glucose transporter),
58.0*
0.00063

member 3

AA421562
934
Hs.91011
Anterior gradient 2 (Xenopus leavis) homolog
56.3*
0.0041

AA100719
212
Hs.73848
Carcinoembroyonic antinge-related cell adhesion molecule 6
50.9*
0.00081

(non-specific cross reacting antigen)

AA335191
741
Hs.173724
Creatine kinase, brain
47.4*
0.00419

H95233
2048
Hs.31439
Serine protease inhibitor, Kunitz type 2
47.1
0

H94471
2042
Hs.171952
Occludin
43.1
0

X93036
3827
Hs.92323
FXYD domain-containing ion transport reglator 3
42.4*
0.00167

AA156243
340
Hs.154737
Serine protease, umbillcal endothelium
41.4*
0.00139

M35252
2343
Hs.84072
Transmembrane 4 superfamily membrane 3
39.1
0

M29540
2317
Hs.220529
Carcinoembryonic antigen-related cell adhesion molecule 5
36.6*
0.0116

N92934
2724
Hs.17409
Cysteine-rich protein 1 (intestinal)
35.5
0.002

AA610116
1149
Hs.102737
Tetraspan NET-6 protein
33.7
0.00171

HG2788-HT2896

Hs.27258
Calycyclin binding protein
33.2
0

AA429009
994
Hs.233950
Serine protease inhibitor, Kunitz type 1
30.0*
0.00001

[0130]

6

TABLE 4B

Top Fifteen Genes that are Underexpressed in Metastatic Carcinomas in the Liver

Unigene

Fold

Accession #
SEQ ID:
Cluster
Gene Name
Change
Pvalue

N54417
2566
Hs.90765
Fibrinogen, A alpha polypeptide
99.3
0.00001

N53031
2555
Hs.89691
UDP glycosyltransferase 2 family, polypeptide B4
97.6
0.00022

M15656
2268
Hs.234234
Aldolase B, fructose-bisphosphate
96.7*
0

T59148
3157
Hs.550966
Carbamoyl-phosphate synthetrase 1, mitochondrial
88.9*
0

R49459
2881
Hs.63758
Transferrin receptor 2
85.6
0.00048

X55283
3731
Hs.1259
Asialoglycoprotein receptor 2
85.0
0.00084

L16883
2166
Hs.167529
Cytochrome P450, subfamily IIC (menphenytoin 4-
84.7
0.00327

hydroxylase), polypeptide 9

T48039
3128
Hs.2351
Protien C (inactivator of coagulation factors Va and VIlla)
84.4
0.00112

H58692
1960
Hs.9520
Formyltetrahydrofolate dehydrogenase
81.4*
0

M81349
2404
Hs.1955
Serum amyloid A4, constitutive
76.2
0.00015

R43174
2847
Hs.1898
Paraoxonase 1
74.0*
0.00038

M16594
2272
Hs.89552
glutathione S-transferase A2
73.2*
0

U22029
3326
Hs.250615
Cytochrome P450, subfamily IIA (phenobarbital-inducible),
72.0*
0

polypeptide 7

AA256367
579
Hs.107966
Paraoxonase 3
70.3
0.00192

K03192
2127
Hs.183584
Cytochrome P450, subfamily IIA (phenobarbital-inducible),
69.9*
0

polypeptide 6

[0131]

7

TABLE 5

Top Fifteen Genes Expressed in Both Hepatocellular Carcinomas and Metastatic

Liver Tumors, not in Normal Liver Tissue

Unigene

HCC Fold

Metastatics Fold
Metastatic

Accession #
SEQ ID:
Cluster
Gene Name
Change
HCC p value
Change
p value

Y00705
3847
Hs.181286
serine protease inhibitor, Kazal type 1
28.9
0.00003
9.8
0.03697

AA610116
1499
Hs.102737
tetraspan NET-6 protein
16.4
0.00249
33.7
0.00171

AA055896
135
Hs.146428
collagen, type V, alpha 1
10.9
0.00907
18.2
0.00146

J03464
2094
Hs.179573
collagen, type I, alpha 2
10.4
0.00979
9.8
0.00028

M94250
2425
Hs.82045
midkine (neurite growth-promoting factor 2)
9.9
0.02104
10.4
0.01818

AA620881
1510
Hs.21858
trinucleotide repeat containing 3
9.5
0.00062
8.7
0.00735

D51276
1678
Hs.81915
leukemia-associated phosphoprotein p18 (stathmin)
9.4
0.00015
4.8
0.00514

D31094
1639
Hs.109798
G8 protein
9.4
0.0048
4.4
0.04845

AA429472
997
Hs.236522
DKFZP434P106 protein
8.8
0.00063
8.3
0.00208

AA452724
1149
Hs.166468
programmed cell death 5
7.7
0.00085
7.2
0.00908

D26129
1635
Hs.78224
ribonuclease, RNase A family, 1 (pancreatic)
6.9
0.00008
5.7
0.03827

AA434418
1036
Hs.72172
KIAA1115 protein
6.8
0.0032
5.1
0.00498

AA335191
741
Hs.173724
creatine kinase, brain
6.5
0.01462
47.4
0.00419

AA204927
425
Hs.77899
tropomyosin 1 (alpha)
6.1
0.0014
7.1
0.00074

H27188
1908
Hs.9930
collagen-binding protein 2 (colligen 2)
5.8
0.01826
4.2
0.02073

[0132]

8

TABLE 6A

Up in Metastatics vs Normal Sample Set 2

Fragment Name
SEQ ID:
Known Gene Name
Fold Change
Direction
Pvalue

AA427468
973
claudin 4
84.43
up
0

H58873
1961
solute carrier family 2 (facilitated glucose transporter), member 1
57.98
up
0.00063

AA421562
934
anterior gradient 2 (Xenepus laevis) homolog
56.3
up
0.0041

J04423
2109
EST
54.11
up
0.02774

carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross

AA100719
212
reacting antigen)
50.88
up
0.00081

AA159525
354
EST
49.39
up
0.00062

J04423
2109
EST
48.05
up
0.02203

AA335191
741
creatine kinase, brain
47.35
up
0.00419

H95233
2048
serine protease inhibitor, Kunitz type, 2
47.06
up
0

N22015
2447
EST
46.61
up
0.00025

carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross

M18728
2285
reacting antigen)
44.82
up
0.00291

AA211483
435
EST
44.07
up
0.00175

H94471
2042
occludin
43.09
up
0

N54841
2571
EST
42.96
up
0.00002

AA055805
132
EST
42.83
up
0.00142

X93036
3827
FXYD domain-containing ion transport regulator 3
42.36
up
0.00167

AA156243
340
serine protease, umbilical endothelium
41.44
up
0.00139

R33498
2819
EST
41.34
up
0.00001

AA291168
696
EST
40.67
up
0.00065

M35252
2343
transmembrane 4 superfamily member 3
39.12
up
0

AA398908
801
EST
38.69
up
0.01089

AA424487
945
EST
38.41
up
0.00002

M29540
2317
carcinoembryonic antigen-related cell adhesion molecule 5
36.57
up
0.0116

N92934
2724
cysteine-rich protein 1 (intestinal)
35.52
up
0.002

AA075299
164
EST
34.27
up
0.00002

AA610116
1499
tetraspan NET-6 protein
33.68
up
0.00171

HG2788-HT2896

calcyclin binding protein
33.15
up
0

W92449
3649
EST
31.67
up
0.00011

T26366
3092
EST
30.43
up
0.00153

AA429009
994
serine protease inhibitor, Kunitz type I
30.04
up
0.00001

AA099404
208
EST
29.07
up
0

AA011134
29
EST
28.79
up
0.00602

W72276
3580
EST
27.39
up
0.00183

M57710
2357
lectin, galactoside-binding, soluble, 3 (galectin 3)
27.12
up
0.00001

AA053102
125
cadherin 17, LI cadherin (liver-intestine)
26.63
up
0.01745

W95477
3661
EST
26.51
up
0.00161

M27826
2313
endogenous retroviral protease
26.36
up
0.00342

AA157818
349
endogenous retroviral protease
25.99
up
0.00153

A372630
769
differentially expressed in hematopoietic lineages
25.49
up
0.01743

T03580
3045
pyruvate kinase, muscle
24.91
up
0.0001

AA463861
1251
EST
24.79
up
0.00096

AA101551
216
EST
24.78
up
0

AA284879
679
EST
24.68
up
0.00001

AA213696
437
poly(A)-binding protein, cytoplasmic 1
24.65
up
0.00001

AA394121
778
laminin receptor 1 (67kD, ribosomal protein SA)
23.78
up
0.00099

AA234096
479
EST
23.72
up
0.00018

AA156187
339
ATP synthase, H+ transporting, mitochondrial FO complex,
23.24
up
0.00006

subunit b, isoform 1

X56494
3735
pyruvate kinase, muscle
22.97
up
0.00001

F09394
1803
K1AA0715 protein
22.89
up
0.01753

M94345
2426
capping protein (actin filament), gelsolin-like
22.38
up
0.00003

AA428964
993
kallikrein 10
21.83
up
0.02324

J04423
2109
EST
21.46
up
0.04283

L08044
2149
trefoil factor 3 (intestinal)
21.42
up
0.01674

AA405791
864
EST
21.22
up
0

LI7131
2168
high-mobility group (nonhistone chromosomal) protein isoforms land Y
20.57
up
0.00058

AA233959
477
EST
19.69
up
0.00101

AA427636
976
EST
19.23
up
0.00145

U78095
3429
serine protease inhibitor, Kunitz type, 2
18.85
up
0

AA161043
356
tetraspan 1
18.8
up
0.00015

D38583
1656
S100 calcium-binding protein A11 (calgizzarin)
18.7
up
0.00003

AA055896
135
collagen, type V, alpha 1
18.16
up
0.00146

AA143763
311
EST
18.09
up
0.00347

AA171760
367
EST
17.86
up
0

H18442
1891
creatine kinase, brain
17.42
up
0.02391

AA422150
939
cytochrome P540 family member predicted from ESTs
17.14
up
0.00108

AA158234
351
EST
17.04
up
0.00711

AA442054
1067
phospholipase C, gamma 1 (formerly subtype 148)
16.89
up
0.00205

AA430032
1009
pituitary tumor-transforming 1
16.87
up
0.00659

AA251299
541
K1AA0014 gene product
16.86
up
0.00046

AA331393
739
EST
16.73
up
0.00848

W93726
3653
protease inhibitor 5 (maspin)
16.48
up
0.00014

M93036
2421
membrane component, chromosomal 4, surface marker (35kD glycoprotein)
16.45
up
0.00308

AA411502
889
EST
16.42
up
0.00241

AA410508
885
EST
16.04
up
0.02635

AA053660
128
EST
15.98
up
0.00003

N98464
2743
EST
15.95
up
0.00004

AA215299
439
U6 snRNA-associated Sm-like protein LSm7
15.84
up
0.00001

M27830
2314
EST
15.53
up
0.00022

AA131919
270
putative type II membrane protein
15.36
up
0.00027

T24068
3087
EST
15.26
up
0.00046

AA253473
567
EST
15.23
up
0.00171

W42957
3513
calmodulin 2 (phosphorylase kinase, delta)
15.22
up
0.00007

AA430674
1018
EST
15.11
up
0.00293

S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light

M38591
2350
polypeptide (p 11))
14.87
up
0

M27830
2314
EST
14.86
up
0.00043

AA485697
1346
EST
14.74
up
0.00102

AA451676
1135
EST
14.72
up
0.00056

X68314
3775
glutathione peroxidase 2 (gastrointestinal)
14.4
up
0.00222

AA372018
768
EST
14.3
up
0.00178

AA135894
295
retinoic acid induced 3
14.27
up
0.00558

Y00503
3846
keratin 19
14.19
up
0.00217

L08044
2149
trefoil factor 3 (intestinal)
14.18
up
0.02124

AA161292
357
interferon, alpha-inducible protein 27
13.84
up
0.00004

AA412405
901
EST
13.82
up
0.01021

C01766
1559
EST
13.67
up
0.00003

AA262943
611
EST
13.42
up
0.00234

U09770
3295
cysteine-rich protein 1 (intestinal)
13.03
up
0.0072

AA227560
458
EST
12.81
up
0.01693

M16364
2269
creatine kinase, brain
12.69
up
0.03633

X57348
3741
stratifin
12.53
up
0.0013

AA429890
1004
cisplatin resistance associated
12.51
up
0.00053

J04164
2108
interferon induced transmembrane protein 1(9-27)
12.37
up
0.00001

X65614
3764
S100 calcium-binding protein P
12.2
up
0.00065

AA134968
289
EST
12.11
up
0.00079

AA134985
290
EST
12.11
up
0.00318

J05257
2118
dipeptidase 1 (renal)
12.02
up
0.02099

T23490
3081
EST
11.86
up
0.03242

N49284
2536
v-myb avian myeloblastosis viral oncogene homolog
11.82
up
0.01981

X76180
3792
sodium channel, nonvoltage-gated 1 alpha
11.68
up
0

AA290674
692
eukaryotic translation initiation factor 4E binding protein 1
11.59
up
0.00036

M10098
2231
EST
11.55
up
0.00099

AA447687
1104
EST
11.42
up
0.00362

D00017
1587
annexinA2
11.38
up
0

H20989
1899
pyruvate kinase, muscle
11.37
up
0.0375

AF003521
1545
jagged 2
11.26
up
0.00008

AA126044
245
EST
11.23
up
0.00041

R95966
2996
EST
11.22
up
0.00682

AA256642
582
EST
11.17
up
0.00035

AA497031
1407
EST
11.05
up
0.04381

R92994
2989
matrix metalloproteinase 12 (macrophage elastase)
11.05
up
0.00248

L33842
2197
IMP (inosine monophosphate) dehydrogenase 2
11.03
up
0.00001

AA026030
53
EST
11.01
up
0.01649

R49476
2882
EST
10.95
up
0.00014

AA404338
849
EST
10.9
up
0.00668

W95348
3660
HSPC113 protein
10.89
up
0.01065

M12125
2241
tropomyosin 2 (beta)
10.83
up
0.00191

U07969
3288
cadherin 17, LI cadherin (liver-intestine)
10.78
up
0.02002

AA338889
745
actin related protein 2/3 complex, subunit 4 (20 kD)
10.77
up
0.03782

AA460017
1225
EST
10.76
up
0.00106

K03195
2128
solute carrier family 2 (facilitated glucose transporter), member 1
10.73
up
0.00139

AA422086
938
EST
10.71
up
0.03418

T53404
3142
EST
10.68
up
0.00582

M27830
2314
EST
10.64
up
0.00213

AA113149
226
tumor suppressing subtransferable candidate 3
10.58
up
0.00543

X83228
3807
cadherin 17, LI cadherin (liver-intestine)
10.58
up
0.02147

X12447
3693
aldolase A, fructose-bisphosphate
10.52
up
0.00038

D51112
1675
collapsin response mediator protein 1
10.48
up
0.00076

Z74615
3946
collagen, type I, alpha 1
10.47
up
0.00064

AA429636
1001
hexokinase 2
10.43
up
0.00597

R71395
2951
EST
10.42
up
0.00422

D83735
1747
calponin 2
10.42
up
0.00001

N31570
2485
TNF receptor-associated factor 5
10.39
up
0.00018

T95057
3258
EST
10.39
up
0.00003

M94250
2425
midkine (neurite growth-promoting factor 2)
10.39
up
0.01818

M10098
2231
EST
10.2
up
0.00027

M24485
2304
glutathione 5-transferase pi
10.2
up
0.00003

AA609013
1477
dipeptidase 1 (renal)
10.17
up
0.00109

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator)

J03592
2096
member 6
10.05
up
0

AA001504
2
EST
9.98
up
0.00336

H89551
2024
EST
9.94
up
0.00137

AA608897
1473
EST
9.92
up
0.00087

X89960
3815
EST
9.87
up
0

Y00705
3847
serine protease inhibitor, Kazal type 1
9.83
up
0.03697

J03464
2094
collagen, type I, alpha 2
9.81
up
0.00028

M27830
2314
EST
9.8
up
0.00041

AA132986
275
EST
9.72
up
0.00552

X67325
3772
interferon, alpha-inducible protein 27
9.67
up
0.03245

AA280734
639
KIAA0618 gene product
9.64
up
0.00003

N46423
2520
EST
9.64
up
0.00027

T03313
3041
dyskeratosis congenita 1, dyskerin
9.63
up
0.00001

AA188378
392
EST
9.56
up
0.00271

AA428172
986
Notch (Drosophila) homolog 3
9.53
up
0.02562

AA454908
1171
KIAA0144 gene product
9.3
up
0.00539

N39237
2510
EST
9.29
up
0.00001

AA133936
284
EST
9.19
up
0.00088

AA235707
500
EST
9.17
up
0.00005

L33930
2198
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
9.16
up
0.01252

H97013
2059
ephrin-A4
9.14
up
0.00346

AA084901
181
ribosomal protein S6 kinase, 70kD, polypeptide 2
9.13
up
0.00003

M38690
2351
CD9 antigen (p24)
9.08
up
0.00059

W78057
3597
EST
9.06
up
0.0034

solute carrier family 11 (proton-coupled divalent metal ion transporters),

N72116
2667
member 2
9.01
up
0.00051

R91819
2983
EST
8.95
up
0.00009

Z39191
3898
EST
8.84
up
0.00011

AA116036
233
chromosome 20 open reading frame 1
8.81
up
0.00133

M27830
2314
EST
8.78
up
0.00003

AA053424
127
EST
8.76
up
0.01775

AA243173
526
EST
8.75
up
0.00003

AA291139
695
EST
8.69
up
0.04573

AA424029
943
EST
8.68
up
0.00081

L09604
2151
proteolipid protein 2 (colonic epithelium-enriched)
8.68
up
0.

AA620881
1510
trinucleotide repeat containing 3
8.66
up
0.00735

AA435665
1040
EST
8.66
up
0.00001

AA451877
1138
EST
8.63
up
0.00489

U79725
3437
glycoprotein A33 (transmembrane)
8.57
up
0.00299

AA043959
101
tropomyosin 4
8.54
up
0.00222

080946
1737
SERS protein kinase 1
8.53
up
0.00455

L21954
2177
benzodiazapine receptor (peripheral)
8.53
up
0.00001

X54667
3728
cystatin S,cystatin SN
8.53
up
0.00059

U47025
3367
phosphorylase, glycogen; brain
8.52
up
0.00134

N62126
2588
EST
8.51
up
0.00016

N73808
2678
EST
8.46
up
0.01886

HG371-HT26388

mucin 1, transmembrane
8.44
up
0.00268

T30193
3097
protease, serine, 8 (prostasin)
8.39
up
0.00043

M32886
2335
sorcin
8.35
up
0.00215

U73379
3417
ubiquitin carrier protein E2-C
8.32
up
0.00101

AA429472
997
DKFZP434P106 protein
8.27
up
0.00208

AA406542
878
EST
8.27
up
0.00724

F04674
1793
K1AA0746 protein
8.2
up
0.00028

M27830
2314
EST
8.2
up
0.00294

T03438
3042
EST
8.18
up
0.00032

R56095
2905
EST
8.16
up
0.00023

AA461187
1236
EST
8.15
up
0.00068

578187
3035
cell division cycle 25B
8.07
up
0.00009

T33489
3104
EST
8.04
up
0.00469

R02036
2753
EST
8.01
up
0.01012

AA295819
722
EST
8
up
0.01793

AA282247
657
EST
8
up
0.00014

U09117
3293
phospholipase C, delta 1
7.96
up
0.00001

AA479797
1316
EST
7.93
up
0.00006

J04469
2111
creatine kinase, mitochondrial 1 (ubiquitous)
7.9
up
0.00705

Z39429
3903
EST
7.84
up
0.00045

AA053033
124
EST
7.83
up
0.00379

Z40945
3924
trinucleotide repeat containing 15
7.82
up
0.00007

R45994
2866
EST
7.81
up
0.0018

F04531
1791
Kell blood group precursor (McLeod phenotype)
7.79
up
0.03205

AA425852
958
EST
7.78
up
0.00239

R48447
2870
EST
7.75
up
0.00049

AA243133
525
serine/threonine kinase 15
7.73
up
0.04328

AA074514
160
EST
7.69
up
0

AA292788
714
EST
7.69
up
0.00967

AA433930
1032
chondroitin 4-sulfotransferase
7.68
up
0.02445

Z23090
3865
heat shock 27kD protein 1
7.67
up
0.00008

AA196790
421
EST
7.64
up
0.00287

F13809
1828
tropomyosin 1 (alpha)
7.62
up
0.00012

U21049
3324
epithelial protein up-regulated in carcinoma, membrane associated protein 17
7.53
up
0.01667

K03460
2129
tubulin, alpha 1 (testis specific)
7.5
up
0.00002

D13639
1607
cyclin D2
7.49
up
0.01641

M31303
2327
leukemia-associated phosphoprotein p18 (stathmin)
7.48
up
0.00021

N69263
2647
EST
7.47
up
0.00004

AF001294
1544
tumor suppressing subtransferable candidate 3
7.45
up
0.00009

U01062
3272
inositol 1,4,5-triphosphate receptor, type 3
7.41
up
0

AA463725
1249
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferas
7.4
up
0.04715

AA403159
845
Ste-20 related kinase
7.33
up
0.00187

M86752
2411
stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)
7.32
up
0.00001

myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog);

W38044

translocated to, 7
7.28
up
0.00105

X04347
3677
heterogeneous nuclear ribonucleoprotein A1
7.26
up
0.00018

AA452724
1149
programmed cell death 5
7.2
up
0.00908

AA151428
335
matrix metalloproteinase 23B
7.15
up
0.00056

R38239
2829
EST
7.14
up
0.00249

AA292765
712
ZW10 interactor
7.14
up
0.02623

AA204927
425
tropomyosin 1 (alpha)
7.09
up
0.00074

D80710
1734
integral type I protein
7.08
up
0.00213

AB006781
1540
lectin, galactoside-binding, soluble, 4 (galectin 4)
7.05
up
0.00913

S54005
3019
thymosin, beta 10
7.03
up
0.00334

AA053248
126
EST
7.01
up
0.00003

AA610053
1496
EST
7.01
up
0.00003

N71781
2665
EST
7.01
up
0.02952

M14199
2258
laminin receptor 1 (67kD, ribosomal protein SA)
7.01
up
0

M55998
2356
collagen, type I, alpha 1
6.99
up
0.00103

T32108
3102
EST
6.96
up
0.00723

AA479044
1307
EST
6.9
up
0.04668

AA449073
1117
EST
6.89
up
0.01445

N22107
2448
EST
6.88
up
0.04259

AA055811
133
glycoprotein A33 (transmembrane)
6.86
up
0.02152

AA226932
453
DKFZP564F0923 protein
6.84
up
0.00405

AA131584
268
DKFZP56400463 protein
6.83
up
0.00025

R56880
2908
EST
6.82
up
0.02559

AA227926
460
EST
6.81
up
0.01701

U42408
3360
ladinin 1
6.8
up
0.00305

F01444
1770
KIAA0440 protein
6.78
up
0.00028

AA419217
923
DKFZP586E1422 protein
6.77
up
0.00045

W92207
3648
EST
6.77
up
0.00002

Z41740
3932
EST
6.76
up
0.00049

AA411813
893
postmeiotic segregation increased 2-like 11
6.76
up
0.03499

AA053007
123
putative receptor protein
6.76
up
0.00061

AA599522
1452
squamous cell carcinoma antigen recognised by T cells
6.75
up
0.04229

L11669
2157
tetracycline transporter-like protein
6.75
up
0.00101

H78211
2001
EST
6.73
up
0.02488

W81540
3611
serine/threonine kinase 24 (Ste20, yeast homolog)
6.72
up
0.00164

R69700
2942
EST
6.71
up
0.0021

AA406145
870
EST
6.71
up
0.00047

X79882
3802
lung resistance-related protein
6.71
up
0.0362

N73762
2677
EST
6.65
up
0.0023

AA429825
1003
DKFZP566B023 protein
6.63
up
0.00032

D55716
1686
minichromosome maintenance deficient (S. cerevisiae) 7
6.6
up
0.00151

AA127712
255
EST
6.59
up
0.03706

W80730
3604
EST
6.59
up
0.00425

Z38266
3883
EST
6.58
up
0.01909

D83783
1748
trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
6.55
up
0.00176

Z28407
3873
ribosomal protein L8
6.53
up
0.00004

AA078862
173
EST
6.52
up
0.00025

AA609614
1487
EST
6.5
up
0.00406

HG2797-HT2906

clathrin, light polypeptide (Lcb)
6.5
up
0.00013

X64364
3761
basigin
6.45
up
0.00041

AA179787
380
polyglutamine binding protein 1
6.44
up
0.00206

R61297
2919
eukaryotic translation initiation factor 3, subunit 6 (48kD)
6.42
up
0.00126

C13992
1564
EST
6.39
up
0.00059

AA148885
320
minichromosome maintenance deficient (S. cerevisiae) 4
6.39
up
0.0125

D28124
1636
neuroblastoma candidate region, suppression of tumorigenicity 1
6.38
up
0.00015

L19605
2170
annexin A11
6.38
up
0.00017

AB002533
1539
karyopherin alpha 4 (importin alpha 3)
6.38
up
0.00003

R70801
2949
EST
6.36
up
0.00563

N47956
2523
eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)
6.34
up
0.00251

L41351
2214
protease, serine, 8 (prostasin)
6.34
up
0.01132

D63486
1712
KIAA0152 gene product
6.33
up
0.00078

HG1153-HT1153

non-metastatic cells 2, protein (NM23B) expressed in
6.31
up
0

AA410469
883
EST
6.3
up
0.00103

AA424881
949
EST
6.3
up
0.00556

AA449456
1126
EST
6.29
up
0.00087

AA430048
1012
KIAAOI6O protein
6.27
up
0.00631

X99133
3839
lipocalin 2 (oncogene 24p3)
6.27
up
0.0453

R79580
2969
EST
6.25
up
0.00593

AA028132
62
EST
6.25
up
0.00646

N66624
2617
homolog of mouse quaking QKI (KH domain RNA binding protein)
6.25
up
0

AA010065
22
CDC28 protein kinase 2
6.25
up
0.02752

M27830
2314
EST
6.25
up
0.00046

W90146
3641
EST
6.23
up
0.01558

AA062721
146
nuclear factor (erythroid-derived 2)-like 1
6.2
up
0.00024

R96924
3000
EST
6.18
up
0.03417

L23808
2179
matrix metalloproteinase 12 (macrophage elastase)
6.18
up
0.02195

AA053248
126
EST
6.16
up
0.00191

AA453783
1158
EST
6.16
up
0.00167

AA478300
1298
CD39-like 2
6.15
up
0.01625

N26186
2467
EST
6.15
up
0.00135

AA425279
951
quiescin Q6
6.15
up
0.00083

AA441911
1066
EST
6.14
up
0.00003

U93205
3460
chloride intracellular channel 1
6.14
up
0.00058

W67251
3567
EST
6.13
up
0.01463

D87953
1765
N-myc downstream regulated
6.12
up
0.00033

secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-

U20758
3322
lymphocyte activation 1)
6.12
up
0.03448

M62895
2375
annexin A2,annexin A2 pseudogene 2
6.11
up
0.00013

AA128561
261
collagen, type XVII, alpha 1
6.09
up
0.0433

U58682
3395
ribosomal protein S28
6.09
up
0.00001

AA479727
1315
EST
6.06
up
0.00389

N80703
2703
EST
6.06
up
0.00003

AA279177
624
lymphocyte antigen 75
6.05
up
0.01821

AA292379
708
EST
6.04
up
0.00568

W74233
3594
related RAS viral (r-ras) oncogene homolog
6.02
up
0.01815

AA007160
16
EST
6
up
0.01035

H09281
1863
EST
6
up
0.00966

Z41798
3934
EST
6
up
0.00073

R97759
3005
serum/glucocorticoid regulated kinase
5.99
up
0.00221

AA284945
680
EST
5.98
up
0.00026

W49574
3535
EST
5.97
up
0.00045

T32072
3101
EST
5.95
up
0.00029

D82558
1746
novel centrosomal protein RanBPM
5.94
up
0.00752

AA463234
1246
KIAA0792 gene product
5.94
up
0.01182

U48705
3369
discoidin domain receptor family, member 1
5.94
up
0.01323

R52161
2892
EST
5.84
up
0.03253

0-linked N-acetylglucosamine (GIcNAc) transferase (UDP-N-

R76782
2962
acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
5.83
up
0.01126

R40254
2839
EST
5.82
up
0.00304

H81413
2007
high-mobility group (nonhistone chromosomal) protein isoforms I andY
5.82
up
0.00769

H75933
1998
laminin receptor 1 (67kD, ribosomal protein SA)
5.81
up
0.00024

T15473
3057
muscle specific gene
5.81
up
0.02404

M27830
2314
EST
5.78
up
0.0017

AA478017
1295
zyxin
5.77
up
0.00484

AA179845
381
EST
5.77
up
0.01414

AA151778
338
claudin 7
5.77
up
0.00002

U78556
3432
cisplatin resistance associated
5.77
up
0.00241

U51478
3384
ATPase, Na+/K+ transporting, beta 3 polypeptide
5.75
up
0.00007

U73843
3420
E74-like factor 3 (ets domain transcription factor)
5.75
up
0.00017

AA236037
506
EST
5.74
up
0.0091

M60784
2366
small nuclear ribonucleoprotein polypeptide A
5.74
up
0.00126

R44538
2855
EST
5.73
up
0.01015

AA287393
688
EST
5.68
up
0.00062

D26129
1635
ribonuclease, RNase A family, 1 (pancreatic)
5.68
up
0.03827

L76191
2222
interleukin-1 receptor-associated kinase 1
5.66
up
0.00089

N52168
2550
EST
5.65
up
0.00003

D51393
1681
ribosomal protein L4
5.64
up
0.00074

T47325
3124
EST
5.63
up
0.01015

M10098
2231
EST
5.62
up
0.00251

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,

M86400
2409
zeta polypeptide
5.62
up
0.00016

M10098
2231
EST
5.61
up
0.01238

D11086
1595
interleukin 2 receptor, gamma (severe combined immunodeficiency)
5.61
up
0.00873

AA093497
199
DEK oncogene (DNA binding)
5.6
up
0.02551

AA452536
1145
v-ral simian leukemia viral oncogene homolog A (ras related)
5.6
up
0.00481

AA279840
632
titin-cap (telethonin)
5.58
up
0.01253

N71072
2663
EST
5.57
up
0.03881

R06251
2763
tumor protein D52-like 2
5.57
up
0.00037

N66951
2620
EST
5.54
up
0.02442

AA188378
392
EST
5.54
up
0.01359

U46692
3366
cystatin B (stefin B)
5.54
up
0.00016

U20499
3320
sulfotransferase family 1A, phenol-preferring, member 3
5.5
up
0.00299

AA287347
687
EST
5.47
up
0.00034

M81757
2405
ribosomal protein S19
5.46
up
0

S81914
3037
immediate early response 3
5.46
up
0.01798

AA262887
610
EST
5.4
up
0.04719

D63487
1713
KIAA0153 protein
5.4
up
0.00027

J05582
2121
mucin 1, transmembrane
5.39
up
0.00056

T23516
3082
3-phosphoglycerate dehydrogenase
5.38
up
0.00001

AA181600
384
EST
5.38
up
0.03316

H99473
2077
regulator of nonsense transcripts 1
5.37
up
0.00177

AA459254
1211
EST
5.36
up
0.0259

C14756
1570
MLN51 protein
5.36
up
0.00001

M10098
2231
EST
5.35
up
0.00186

AA485405
1343
EST
5.35
up
0.03475

N69252
2646
ferritin, light polypeptide
5.33
up
0.01554

HG1612-HT1612

MARCKS-like protein
5.32
up
0.00007

M20471
2289
clathrin, light polypeptide (Lca)
5.32
up
0.00344

AA126719
250
EST
5.31
up
0.00026

T16308
3068
EST
5.29
up
0.00119

AA335091
740
EST
5.28
up
0.0009

AA189015
394
EST
5.27
up
0.00004

AA450247
1133
EST
5.27
up
0.02833

HG1614-HT1614

protein phosphatase 1, catalytic subunit, alpha isoform
5.27
up
0.00257

L19686
2171
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
5.26
up
0.00562

membrane component, chromosome 1, surface marker I (40kD glycoprotE

J04152
2107
identified by monoclonal antibody GA733)
5.26
up
0.02466

U14972
3306
ribosomal protein S10
5.24
up
0.00077

AA459388
1215
copine I
5.23
up
0.00691

T16983
3073
cleavage and polyadenylation specific factor 4, 30kD subunit
5.23
up
0.00075

C15324
1574
EST
5.22
up
0.00344

L04490
2137
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 (39kD)
5.22
up
0.02192

AA291137
694
EST
5.21
up
0.00685

R38511
2831
protein similar to E. coli yhdg and R. capsulatus nifRe
5.19
up
0.00015

R06866
2773
EST
5.18
up
0.00187

D20906
1627
EST
5.18
up
0.02189

H05625
1847
EST
5.17
up
0.04551

AA011383
31
EST
5.17
up
0.00008

N20198
2439
ubiquitin-conjugating enzyme E2 variant 1
5.17
up
0.00508

AA490494
1377
EST
5.16
up
0.01696

S69272
3027
protease inhibitor 6 (placental thrombin inhibitor)
5.15
up
0.00003

AA471278
1277
BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog
5.14
up
0.00873

AA026150
55
EST
5.14
up
0.01072

kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2

AA086232
186
leukocyte antigen, antigen detected by monoclonal and antibody IA4))
5.14
up
0.01916

AA620466
1502
EST
5.14
up
0.00004

X17206
3715
ribosomal protein S2
5.14
up
0

J04423
2109
EST
5.13
up
0.02791

W92608
3650
BAI1-associated protein 3
5.12
up
0.00075

AA434418
1036
KIAA1115 protein
5.12
up
0.00498

AA482319
1335
putative type II membrane protein
5.11
up
0.00177

AA249819
535
EST
5.09
up
0.00136

AA442763
1072
cyclin B2
5.09
up
0.02168

protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha

T26513
3094
isoform
5.07
up
0.0016

H09271
1862
EST
5.06
up
0.0016

H88674
2021
collagen, type I, alpha 2
5.06
up
0.00866

X98482
3838
EST
5.03
up
0.00002

H43286
1929
gamma-aminobutyric acid (GABA) B receptor, 1
5.02
up
0.01972

AA364267
762
EST
5.01
up
0.00255

AA464963
1265
EST
5.01
up
0.00107

AA147439
315
EST
5.01
up
0.00336

T15442
3056
calpain, large polypeptide L1
5.01
up
0.00255

N77947
2697
EST
5
up
0.00117

L06505
2142
ribosomal protein L12
5
up
0.00163

AA280283
637
EST
4.99
up
0.02644

AA447991
1112
EST
4.99
up
0.00173

AA464414
1258
EST
4.99
up
0.00529

AA075580
165
EST
4.98
up
0.02083

U17077
3313
BENE protein
4.98
up
0.00366

AA476216
1279
EST
4.97
up
0.00359

AA132554
273
EST
4.96
up
0.02076

AA504270
1411
EST
4.96
up
0.01919

R48589
2873
EST
4.95
up
0.01346

R58974
2909
EST
4.95
up
0.00498

AA283085
667
EST
4.93
up
0.00382

AA489712
1372
EST
4.93
up
0.00726

AA496981
1404
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
4.93
up
0.01096

D14520
1613
basic transcription element binding protein 2
4.93
up
0.00004

AA402495
838
EST
4.91
up
0.00235

U15008
3308
small nuclear ribonucleoprotein D2 polypeptide (16.5kD)
4.9
up
0.00396

AA406218
872
EST
4.88
up
0.02194

AA482127
1333
protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
4.88
up
0.00017

M79463
2401
promyelocytic leukemia
4.88
up
0.01821

AA146619
312
EST
4.87
up
0.00863

AA262477
608
ribonuclease HI, large subunit
4.87
up
0.00005

AA121315
237
KIAA1077 protein
4.86
up
0.02438

H38568
1918
EST
4.86
up
0.0003

AA306121
729
EST
4.85
up
0.00381

D51133
1676
tubulin, beta, 4
4.84
up
0.02875

W02041
3465
EST
4.83
up
0.00158

T55004
3145
EST
4.83
up
0.00156

Z74616
3947
collagen, type I, alpha 2
4.83
up
0.02364

X17093
3713
EST
4.82
up
0.00176

D51276
1678
leukemia-associated phosphoprotein p18 (stathmin)
4.81
up
0.00514

M77349
2399
transforming growth factor, beta-induced, 68kD
4.81
up
0.00546

AA425852
958
EST
4.8
up
0.03874

R22565
2799
EST
4.8
up
0.0424

M10098
2231
EST
4.79
up
0.00328

D13413
1604
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
4.79
up
0.00092

H46486
1932
nesca protein
4.77
up
0.00421

U51095
3381
caudal type homeo box transcription factor 1
4.76
up
0.02664

AA609786
1491
nucleolar protein 1 (l20kD)
4.75
up
0.00261

AA251230
540
EST
4.75
up
0.00054

AA459703
1222
v-myc avian myelocytomatosis viral oncogene homolog
4.75
up
0.02413

AA131084
265
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
4.74
up
0.00427

D50914
1673
KIAA0124 protein
4.74
up
0.00752

T35341
3111
EST
4.73
up
0.00057

AA253011
558
KIAA0713 protein
4.73
up
0.01944

X74929
3789
keratin 8
4.73
up
0.00018

D25560
1634
EST
4.72
up
0.00661

X62535
3753
diacylglycerol kinase, alpha (80kD)
4.72
up
0.00315

X66899
3769
Ewing sarcoma breakpoint region 1
4.72
up
0.00011

X68688
3777
zinc finger protein 33a (KOX 31)
4.7
up
0.00062

AB000584
1533
prostate differentiation factor
4.7
up
0.00071

AA293719
720
EST
4.69
up
0.02181

R39191
2833
KIAA1020 protein
4.69
up
0.00456

AA598405
1424
membrane interacting protein of RGS16
4.69
up
0.0122

U12465
3299
ribosomal protein L35
4.69
up
0.00001

AA405715
862
hypothetical protein
4.68
up
0.00898

AA131162
266
EST
4.68
up
0.00042

U78525
3431
eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)
4.68
up
0.00132

AA171939
368
EST
4.67
up
0.00104

M10098
2231
EST
4.66
up
0.00405

AA298786
727
EST
4.65
up
0.02821

N93798
2737
protein tyrosine phosphatase type IVA, member 3
4.65
up
0.00118

R06254
2764
tumor protein D52-like 2
4.64
up
0.00039

L20591
2173
annexin A3
4.64
up
0.00065

U14969
3303
ribosomal protein L28
4.63
up
0.00004

AA482224
1334
putative type II membrane protein
4.62
up
0.0105

T26471
3093
EST
4.62
up
0.01091

R70005
2943
EST
4.61
up
0.00037

HG3548-HT3749

cut (Drosophila)-like 1 (CCAAT displacement protein)
4.61
up
0.00824

H43646
1930
H2A histone family, member Y
4.6
up
0.00147

AA455521
1178
E2F transcription factor 5, p130-binding
4.6
up
0.00773

H05525
1846
hypothetical protein
4.6
up
0.0033

S56151
3020
milk fat globule-EGF factor 8 protein
4.59
up
0.0091

AA143493
310
pleckstrin 2 (mouse) homolog
4.58
up
0.01037

F04444
1788
EST
4.57
up
0.01132

AA412301
899
EST
4.57
up
0.00026

D31417
1645
secreted protein of unknown function
4.56
up
0.00014

AA025277
51
EST
4.56
up
0.03136

AA478415
1299
EST
4.56
up
0.00095

HG3364-HT3541

ribosomal protein L37
4.55
up
0.00005

M24194
2302
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
4.55
up
0.00017

AA261907
603
DKFZP566E144 protein
4.54
up
0.02289

U04313
3283
protease inhibitor 5 (maspin)
4.54
up
0.02986

AA287022
685
thymidine kinase 1, soluble
4.51
up
0.02582

M34182
2340
protein kinase, cAMP-dependent, catalytic, gamma
4.51
up
0.00043

D38548
1655
KIAA0076 gene product
4.5
up
0.00036

X69150
3779
ribosomal protein S18
4.5
up
0.00003

AA262969
613
ferritin, heavy polypeptide 1
4.49
up
0.00013

M22960
2296
protective protein for beta-galactosidase (galactosialidosis)
4.49
up
0.00898

AA094752
203
hypothetical 43.2 Kd protein
4.47
up
0.00243

J04423
2109
EST
4.47
up
0.02754

T98284
3267
EST
4.47
up
0.00054

HG2873-HT3017

ribosomal protein L30
4.47
up
0.00009

Z24727
3868
tropomyosin 1 (alpha)
4.47
up
0.00121

U75285
3421
apoptosis inhibitor 4 (survivin)
4.46
up
0.02212

M14483
2261
prothymosin, alpha (gene sequence 28)
4.46
up
0.00686

J03827
2100
nuclease sensitive element binding protein 1
4.45
up
0.00015

X15940
3706
ribosomal protein L31
4.45
up
0.00004

N31597
2486
DKFZP564G2022 protein
4.44
up
0.00085

N21359
2441
EST
4.43
up
0.00078

Z26876
3871
ribosomal protein L38
4.43
up
0.00022

N39099
2507
EST
4.42
up
0.00643

N39254
2511
EST
4.42
up
0.00478

T77733
3218
tubulin, gamma 1
4.42
up
0.00049

D31094
1639
G8 protein
4.41
up
0.04845

AA482546
1336
KIAA0124 protein
4.41
up
0.00604

N70903
2661
EST
4.41
up
0.0078

AA070827
157
EST
4.41
up
0.01902

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like

Z25749
3869
2
4.41
up
0.00031

N68921
2638
EST
4.4
up
0.00989

T23465
3080
EST
4.4
up
0.017

AA147084
314
proliferation-associated 2G4, 38kD
4.4
up
0.0045

W52858
3542
DKFZPS64F0522 protein
4.38
up
0.00088

R49395
2880
EST
4.38
up
0.00112

D53139
1684
ribosomal protein 528
4.38
up
0.0009

H18412
1890
isocitrate dehydrogenase 3 (NAD+) gamma
4.37
up
0.00262

U25789
3333
ribosomal protein L21
4.37
up
0.00045

J04423
2109
EST
4.35
up
0.01245

AA236714
516
nuclear mitotic apparatus protein 1
4.35
up
0.00083

U90913
3458
Tax interaction protein 1
4.35
up
0.00159

L44538
2217
EST
4.34
up
0.04319

L06499
2141
ribosomal protein L37a
4.34
up
0.01103

M17886
2282
ribosomal protein, large, P1
4.34
up
0.00044

AA320369
735
chromosome 19 open reading frame 3
4.33
up
0.00554

AA598988
1442
EST
4.32
up
0.00044

R26744
2803
midline 1 (Opitz/BBB syndrome)
4.32
up
0.00532

W44557
3515
chromosome 1 open reading frame 2
4.32
up
0.00128

AA173430
371
EST
4.32
up
0.04362

L34587
2200
transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C)
4.32
up
0.00287

X06617
3684
ribosomal protein S11
4.32
up
0.0002

W93943
3654
EST
4.3
up
0.00296

AA608579
1464
paired-like homeodomain transcription factor 2
4.29
up
0.04435

W60486
3555
EST
4.29
up
0.00964

L11566
2156
ribosomal protein L18
4.29
up
0.00014

HG1980-HT2023

tubulin, beta polypeptide
4.29
up
0.00408

AA122386
239
collagen, type V, alpha 2
4.28
up
0.005

H38240
1916
thrombospondin 2
4.28
up
0.0066

X64707
3762
ribosomal protein L13
4.28
up
0.00257

Y10807
3857
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
4.28
up
0.00124

AA070206
155
EST
4.26
up
0.00018

N89670
2708
EST
4.26
up
0.00002

D63880
1715
KIAA0159 gene product
4.26
up
0.00253

AA431719
1025
EST
4.25
up
0.00015

Z40583
3919
EST
4.24
up
0.02375

AA426447
965
EST
4.23
up
0.0309

AA453477
1153
X-prolyl aminopeptidase (aminopeptidase P)-Iike
4.23
up
0.0001

AA278817
618
EST
4.22
up
0.00061

HG2239-HT2324

potassium voltage-gated channel, Shaw-related subfamily, member 3
4.22
up
0.0065

AA033790
74
apolipoprotein D
4.21
up
0.03247

N70678
2659
TAR (HIV) RNA-binding protein 1
4.2
up
0.00119

W45487
3521
dynamin 2
4.2
up
0.00325

L04483
2136
ribosomal protein S21
4.2
up
0.00057

AA132032
271
trinucleotide repeat containing 1
4.19
up
0.00295

AA282149
654
huntingtin interacting protein-1-related
4.19
up
0.00091

R59352
2914
KIAA0296 gene product
4.19
up
0.00393

D88154
1766
villin-like
4.18
up
0.00051

D59322
1694
EST
4.18
up
0.00006

U12404
3298
ribosomal protein L10a
4.18
up
0.00004

S73885
3031
transcription factor AP-4 (activating enhancer-binding protein 4)
4.18
up
0.00005

AA398205
789
EST
4.17
up
0.00004

H09241
1861
EST
4.17
up
0.00727

HG1800-HT1823

ribosomal protein 520
4.17
up
0.00001

H27188
1908
collagen-binding protein 2 (colligen 2)
4.16
up
0.02073

H56345
1950
EST
4.15
up
0.00488

M17733
2280
thymosin, beta 4, X chromosome
4.15
up
0.00009

U78027
3428
EST
4.15
up
0.00295

AA482613
1338
DKFZP434B203 protein
4.14
up
0.00186

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase),

F09788
1808
alpha polypeptide II
4.14
up
0.00003

R44479
2854
KIAA0552 gene product
4.14
up
0.0181

AA075722
166
nuclear transport factor 2 (placental protein 15)
4.14
up
0.00374

U31556
3345
E2F transcription factor 5, p130-binding
4.14
up
0.01157

AA263044
615
H2A histone family, memberY
4.13
up
0.00024

AA256273
577
EST
4.13
up
0.03874

AA443316
1075
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
4.13
up
0.01729

X80822
3805
ribosomal protein L18a
4.13
up
0.0006

AA224502
451
EST
4.12
up
0.00694

AA461476
1243
EST
4.12
up
0.00871

R31107
2811
EST
4.12
up
0.00003

R43952
2852
homeo box B5
4.11
up
0.04316

R36947
2824
calcium channel, voltage-dependent, beta 3 subunit
4.11
up
0.00006

T40849
3115
maternal G10 transcript
4.11
up
0.00449

X14850
3703
H2A histone family, member X
4.11
up
0.0001

AA026356
57
EST
4.1
up
0.00133

D50663
1671
t-complex-associated-testis-expressed 1-like 1
4.09
up
0.00208

X03342
3672
ribosomal protein L32
4.09
up
0.00008

X62691
3754
ribosomal protein S15a
4.09
up
0.00005

R38076
2827
EST
4.08
up
0.00374

Z39079
3897
KIAA1058 protein
4.08
up
0.01781

D57489
1689
chaperonin containing TCP1, subunit 7 (eta)
4.08
up
0.00001

N50048
2541
EST
4.08
up
0.00085

M87339
2414
replication factor C (activator 1)4 (37kD)
4.07
up
0.00316

C14348
1568
EST
4.06
up
0.00111

H05394
1845
K1AA0266 gene product
4.06
up
0.0015

H97809
2063
EST
4.05
up
0.00111

T47601
3125
EST
4.05
up
0.00878

U62962
3403
eukaryotic translation initiation factor 3, subunit 6 (48kD)
4.05
up
0.0047

T55196
3146
EST
4.04
up
0.00012

AA431873
1028
EST
4.03
up
0.00785

N66139
2614
neurochondrin
4.03
up
0.00118

HG3214-HT3391

ribosomal protein S27 (metallopanstimulin 1)
4.03
up
0.00238

AA405460
857
EST
4.02
up
0.03492

AA236533
514
ecotropic viral integration site 1
4.01
up
0.02882

T91116
3251
EST
4.01
up
0.02721

AA034378
77
endogenous retroviral protease
4.01
up
0.00974

D49400
1667
ATPase, vacuolar, 14 kD
4.01
up
0.00287

M32405
2334
ribosomal protein S15
4.01
up
0.00055

U14968
3302
ribosomal protein L27a
4.01
up
0.00003

W31382
3494
EST
4
up
0.00058

D86956
1753
heat shock 105kD
4
up
0.03013

X70040
3785
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
4
up
0.00402

M13934
2255
ribosomal protein S14
3.99
up
0

H53657
1945
adenylate cyclase 3
3.98
up
0.0045

W28362
3487
K1AA0974 protein
3.98
up
0.00626

W20391
3478
kinesin-like 2
3.98
up
0.01788

AA292931
715
EST
3.97
up
0.00067

H13532
1881
ribosomal protein L18a
3.97
up
0.00061

T66935
3178
EST
3.97
up
0.00188

L03411
2134
RD RNA-binding protein
3.97
up
0.00422

AA291456
700
EST
3.96
up
0.03633

AA496245
1398
EST
3.96
up
0.0039

U85773
3448
phosphomannomutase 2
3.94
up
0.00288

F09297
1800
EST
3.94
up
0.0016

H93492
2037
EST
3.94
up
0.01136

U53830
3390
interferon regulatory factor 7
3.94
up
0.03147

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP

82348
1744
cyclohydrolase
3.93
up
0.00037

U14971
3305
ribosomal protein S9
3.93
up
0.00026

X52966
3723
ribosomal protein L35a
3.93
up
0.00217

AF004709
1547
mitogen-activated protein kinase 13
3.92
up
0.0009

D87735
1764
ribosomal protein L14
3.92
up
0.00015

M17885
2281
ribosomal protein, large, P0
3.92
up
0.00003

D63391
1710
platelet-activating factor acetyihydrolase, isoform Ib, gamma subunit (29kD)
3.91
up
0.00062

X77588
3796
N-acetyltransferase, homolog of S. cerevisiae ARD1
3.91
up
0.0221

M29277
2316
melanoma adhesion molecule
3.91
up
0.00112

C14412
1569
HSPC038 protein
3.9
up
0.00036

AA215468
441
ADP-ribosylation factor-related protein 1
3.9
up
0.04549

H29565
1913
EST
3.89
up
0.01856

AA234362
481
EST
3.89
up
0.03524

X51521
3718
villin 2 (ezrin)
3.89
up
0.00001

AA253330
562
adaptor-related protein complex 1, gamma 1 subunit
3.87
up
0.00708

AA191708
400
EST
3.87
up
0.01904

N91023
2715
EST
3.87
up
0.00008

N98758
2744
EST
3.87
up
0.0074

L40379
2210
thyroid receptor interacting protein 10 (CDC42-interacting protein)
3.87
up
0.00207

N92775
2722
amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)
3.86
up
0.00577

AA187938
391
EST
3.86
up
0.00512

Z30643
3876
chloride channel Ka
3.86
up
0.00204

C21248
1585
pituitary tumor-transforming I
3.85
up
0.00456

D86974
1756
K1AA0220 protein
3.85
up
0.0161

HG821-HT821

ribosomal protein S13
3.84
up
0.00003

X80909
3806
nascent-polypeptide-associated complex alpha polypeptide
3.84
up
0.00399

W76097
3596
EST
3.83
up
0.00001

AA291659
702
EST
3.83
up
0.01934

W80763
3605
EST
3.83
up
0.01319

AA026092
54
EST
3.83
up
0.04596

AA411685
890
EST
3.83
up
0.00417

Z41103
3926
trinucleotide repeat containing 15
3.83
up
0.00444

AA455522
1179
EST
3.83
up
0.00017

D21063
1628
minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin)
3.83
up
0.00983

D42085
1658
KIAA0095 gene product
3.83
up
0.00036

HG3039-HT3200

ADP-ribosylation factor 1
3.83
up
0.00077

L33075
2195
IQ motif containing GTPase activating protein 1
3.83
up
0.00015

M77232
2398
ribosomal protein S6
3.82
up
0.00045

R56678
2907
EST
3.81
up
0.02242

AA621277
1520
EST
3.81
up
0.00194

AA437387
1064
EST
3.81
up
0.01478

N49738
2538
EST
3.81
up
0.02479

AA504264
1410
EST
3.81
up
0.00684

U53347
3388
solute carrier family 1 (neutral amino acid transporter), member 5
3.81
up
0.00273

X55954
3733
ribosomal protein L23
3.81
up
0.00025

D54296
1685
KIAA0255 gene product
3.8
up
0.01059

M30496
2324
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
3.8
up
0.00478

U11861
3297
maternal G10 transcript
3.8
up
0.00001

N27186
2469
EST
3.79
up
0.00112

H49637
1940
EST
3.79
up
0.01092

M18000
2283
ribosomal protein S17
3.79
up
0.00004

U09564
3294
SFRS protein kinase 1
3.79
up
0.00765

F09684
1805
EST
3.78
up
0.00277

AA128407
259
EST
3.78
up
0.01081

R28636
2808
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
3.78
up
0.00765

L12350
2160
thrombospondin 2
3.78
up
0.00061

N93105
2727
EST
3.77
up
0.02195

HG3945-HT4215

phospholipid transfer protein
3.77
up
0.03169

AA131894
269
EST
3.76
up
0.00384

T48195
3130
eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)
3.75
up
0.00012

N68038
2631
phorbolin (similar to apolipoprotein B mRNA editing protein)
3.75
up
0.01041

AA437368
1063
EST
3.75
up
0.01317

M15205
2265
thymidine kinase 1, soluble
3.75
up
0.00159

AA620995
1512
EST
3.74
up
0.03414

M10098
2231
EST
3.73
up
0.01794

AA113303
227
transmembrane 4 superfamily member (tetraspan NET-7)
3.73
up
0.00084

ATP synthase, H +transporting, mitochondrial FO complex, subunit c (subunit

X69908
3783
9), isoform 2
3.73
up
0.00685

AA179298
378
stomatin-like protein 2
3.72
up
0.00299

M96739
2433
nescient helix loop helix 1
3.72
up
0.00015

X55715
3732
ribosomal protein S3
3.72
up
0.00755

AA436027
1050
EST
3.71
up
0.03676

H04799
1841
EST
3.71
up
0.04109

Z40898
3922
EST
3.71
up
0.01168

AA025166
50
fusion, derived from t(12;16) malignant liposarcoma
3.71
up
0.0052

AA150053
327
EST
3.71
up
0.00102

AA490212
1375
H2A histone family, member Y
3.71
up
0.01226

AA307748
730
EST
3.7
up
0.00001

N29888
2482
EST
3.7
up
0.00226

AA034499
78
zinc finger protein 198
3.7
up
0.02143

D14657
1615
KIAA0101 gene product
3.7
up
0.04079

L38696
2208
RNA-binding protein (autoantigenic)
3.7
up
0.00093

AA416963
911
EST
3.69
up
0.03956

AA496204
1397
EST
3.69
up
0.01097

AA435526
1037
transferrin receptor (p90, CD71)
3.69
up
0.00139

AA126459
248
DKFZP566B023 protein
3.69
up
0.00352

H78323
2002
transcription factor Dp-1
3.69
up
0.00326

W73189
3586
EphB2
3.68
up
0.02909

AA029356
66
EST
3.68
up
0.01545

C14051
1565
phosphoprotein enriched in astrocytes 15
3.68
up
0.01453

R38280
2830
BCS1 (yeast homolog)-like
3.68
up
0.0009

proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional

X66401
3768
protease 2)
3.68
up
0.01385

X69398
3781
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
3.68
up
0.02332

AA429470
996
EST
3.67
up
0.00782

L25081
2180
ras homolog gene family, member C
3.67
up
0.00005

M23613
2301
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
3.67
up
0.00977

AA328993
738
EST
3.66
up
0.00146

W39183
3505
KIAA0601 protein
3.66
up
0.00018

AA211851
436
EST
3.66
up
0.00789

X53331
3724
matrix Gla protein
3.66
up
0.04038

AA621780
1530
CGI-96 protein
3.65
up
0.01582

AA449122
1119
EST
3.65
up
0.00369

W70336
3576
EST
3.65
up
0.01776

AA029215
64
adaptor-related protein complex 2, beta 1 subunit
3.65
up
0.00037

N27334
2470
EST
3.65
up
0.03437

U37689
3355
polymerase (RNA) II (DNA directed) polypeptide H
3.65
up
0.00044

D38073
1651
minichromosome maintenance deficient (S. cerevisiae) 3
3.65
up
0.01869

R49216
2879
EST
3.64
up
0.0004

R87989
2978
centrosome associated protein
3.64
up
0.00008

AA135407
292
endogenous retroviral protease
3.64
up
0.01086

AA148977
322
EST
3.64
up
0.02911

D63874
1714
high-mobility group (nonhistone chromosomal) protein 1
3.64
up
0.00228

AA454597
1166
EST
3.63
up
0.0067

F04320
1786
replication factor C (activator 1) 4 (37 kD)
3.63
up
0.01119

X68688
3777
zinc finger protein 33a (KOX 31)
3.62
up
0.00319

R27432
2807
EST
3.62
up
0.00014

AA401958
832
EST
3.62
up
0.01232

HG2279-HT2375

triosephosphate isomerase 1
3.62
up
0.00192

AA416973
913
EST
3.61
up
0.0091

N62675
2593
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16
3.61
up
0.04034

T15477
3058
EST
3.61
up
0.00005

AA460017
1225
EST
3.61
up
0.00109

D43950
1660
chaperonin containing TCP1, subunit 5 (epsilon)
3.61
up
0.00672

N99505
2745
EST
3.6
up
0.04499

AA443271
1073
KIAA0546 protein
3.6
up
0.01228

N89937
2710
LIM domain only 7
3.6
up
0.01375

R71082
2950
programmed cell death 5
3.6
up
0.01338

AA412720
905
EST
3.6
up
0.01396

X17567
3716
small nuclear ribonucleoprotein polypeptides B and B1
3.59
up
0.00586

AA399226
803
tight junction protein 3 (zona occludens 3)
3.59
up
0.02002

R55470
2903
EST
3.59
up
0.00515

X79234
3800
ribosomal protein L11
3.58
up
0.00051

D80917
1736
KIAA0670 protein/acinus
3.58
up
0.00007

W81375
3610
EST
3.58
up
0.00322

U89606
3451
pyridoxal (pyridoxine, vitamin B6) kinase
3.58
up
0.00322

X05610
3682
collagen, type IV, alpha 2
3.57
up
0.01351

AA443941
1085
tumor suppressing subtransferable candidate 1
3.57
up
0.01685

N56935
2574
EST
3.57
up
0.00282

N68385
2634
ribosomal protein L13a
3.57
up
0.00417

R49084
2878
KIAA0770 protein
3.57
up
0.00447

U83246
3442
copine I
3.56
up
0.01672

AA182001
386
EST
3.56
up
0.00945

N51342
2544
EST
3.56
up
0.0001

W42627
3508
EST
3.56
up
0.00198

X66364
3767
cyclin-dependent kinase 5
3.55
up
0.02824

AA451680
1136
hepatocellular carcinoma associated protein; breast cancer associated gene 1
3.55
up
0.00708

Z38909
3894
EST
3.55
up
0.03195

T48293
3132
EST
3.55
up
0.01355

W37680
3502
EST
3.55
up
0.01036

AA252994
557
apoptosis inhibitor 4 (survivin)
3.55
up
0.00075

AA134052
285
Rab geranylgeranyltransferase, alpha subunit
3.54
up
0.03062

AA504806
1416
EST
3.54
up
0.00221

T12599
3055
ribosomal protein L21
3.54
up
0.01437

L19527
2169
ribosomal protein L27
3.54
up
0.00025

U17760
3314
laminin, beta 3 (nicein (125 kD), kalinin (140 kD), BM600 (125 kD))
3.54
up
0.01853

AA056361
140
integral membrane protein 2C
3.53
up
0.02983

H55437
1948
kraken-like
3.53
up
0.02344

C14098
1566
EST
3.53
up
0.04401

H98924
2072
chromatin assembly factor 1, subunit A (p150)
3.53
up
0.02106

AA094517
202
EST
3.52
up
0.04805

AA237017
521
KIAA1068 protein
3.52
up
0.00976

T58607
3154
EST
3.52
up
0.04102

AA028103
61
EST
3.52
up
0.01142

M136547
302
EST
3.51
up
0.00308

AA151182
332
EST
3.51
up
0.00043

AA400271
814
EST
3.51
up
0.00742

U93868
3462
polymerase (RNA) III (DNA directed) (32 kD)
3.5
up
0.01235

W73914
3592
EST
3.5
up
0.04782

AA482007
1331
EST
3.49
up
0.00167

AA452259
1143
EST
3.49
up
0.00114

HG3549-HT3751

ribosomal protein L10
3.49
up
0

U79266
3433
protein predicted by clone 23627
3.49
up
0.00004

X07820
3692
matrix metalloproteinase 10 (stromelysin 2)
3.49
up
0.00689

H08863
1859
hypothetical protein
3.48
up
0.00205

AA292659
710
EST
3.48
up
0.00037

AA432162
1029
DKFZP586B2022 protein
3.48
up
0.03851

T92935
3254
EST
3.48
up
0.03578

X67247
3771
mitogen-activated protein kinase kinase kinase kinase 3
3.48
up
0.00012

AA426521
967
Sjogren's syndrome nuclear autoantigen 1
3.47
up
0.01161

AA489707
1371
EST
3.47
up
0.03433

AA609008
1475
EST
3.46
up
0.02935

L36720
2205
bystin-like
3.46
up
0.00094

D21261
1629
transgelin 2
3.46
up
0.00685

AA446968
1097
EST
3.45
up
0.02232

AA459310
1214
EST
3.45
up
0.00179

N30436
2483
EST
3.45
up
0.02356

AA410962
887
peroxisome proliferative activated receptor, delta
3.45
up
0.04574

F02800
1780
EST
3.45
up
0.03238

U14970
3304
ribosomal protein S5
3.45
up
0.00915

U26726
3335
hydroxysteroid (11-beta) dehydrogenase 2
3.45
up
0.02342

H17476
1889
EST
3.44
up
0.00479

D19737
1623
golgi autoantigen, golgin subfamily a, 3
3.44
up
0.02212

U76366
3423
Treacher Collins-Franceschetti syndrome 1
3.44
up
0.00021

L40904
2212
peroxisome proliferative activated receptor, gamma
3.43
up
0.03511

AA427442
971
guanine nucleotide regulatory factor
3.43
up
0.01547

R77631
2966
EST
3.43
up
0.00006

AA398761
799
EST
3.43
up
0.00726

D80662
1733
adaptor-related protein complex 1, gamma 2 subunit
3.43
up
0.00108

M77836
2400
pyrroline-5-carboxylate reductase 1
3.43
up
0.00759

T78922
3221
stem cell growth factor; lymphocyte secreted C-type lectin
3.42
up
0.02419

N51053
2542
eukaryotic translation initiation factor 5
3.42
up
0.01326

AA134158
287
EST
3.42
up
0.0277

AA454710
1168
EST
3.42
up
0.00653

AA446949
1096
EST
3.41
up
0.03411

AA164252
358
VGF nerve growth factor inducible
3.41
up
0.00154

T59161
3158
thymosin, beta 10
3.41
up
0.01885

T35725
3112
EST
3.4
up
0.00149

M60854
2367
ribosomal protein S16
3.4
up
0.00001

AA135871
294
EST
3.39
up
0.01544

AA599244
1448
KIAA0530 protein
3.39
up
0.01246

D25274
1632
EST
3.39
up
0.00238

U33286
3348
chromosome segregation 1 (yeast homolog)-like
3.39
up
0.00939

AA384184
774
DKFZP586B0519 protein
3.38
up
0.01209

H04753
1839
EST
3.38
up
0.02447

AA422049
937
EST
3.38
up
0.0067

AA233886
475
D site of albumin promoter (albumin D-box) binding protein
3.38
up
0.0218

U86409
3449
EST
3.38
up
0.00003

X52851
3722
EST
3.38
up
0.0001

U84720
3445
RAE1 (RNA export 1, S.pombe) homolog
3.37
up
0.03586

M31520
2328
ribosomal protein S24
3.37
up
0.00077

AA458890
1206
EST
3.36
up
0.00303

AA504413
1413
EST
3.35
up
0.00079

AA001409
1
EST
3.35
up
0.04092

AA251909
549
EST
3.35
up
0.03937

AA461473
1242
nebulette
3.35
up
0.03855

J04823
2115
cytochrome c oxidase subunit VIII
3.35
up
0.00075

M26708
2311
prothymosin, alpha (gene sequence 28)
3.35
up
0.00064

AA370163
766
EST
3.34
up
0.00643

AA149889
326
neighbor of A-kinase anchoring protein 95
3.34
up
0.02054

U22376
3327
v-myb avian myeloblastosis viral oncogene homolog
3.34
up
0.03416

stress-associated endoplasmic reticulum protein 1; ribosome associated

C00021
1551
membrane protein 4
3.33
up
0.00215

AA156450
342
EST
3.33
up
0.00587

AA338729
743
EST
3.33
up
0.00046

D83783
1748
trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
3.33
up
0.00748

HG4542-HT4947

ribosomal protein L15
3.33
up
0.00023

AA427825
981
EST
3.33
up
0.01615

D43949
1659
KIAA0082 protein
3.32
up
0.0014

D50913
1672
KIAA0123 protein
3.32
up
0.01202

AA478599
1304
G protein-coupled receptor 56
3.31
up
0.00182

H93021
2033
peptidylprolyl isomerase A (cyclophilin A)
3.31
up
0.0183

R53109
2898
dimethylarginine dimethylaminohydrolase 2
3.31
up
0.02389

AA132983
274
DKFZP586G1517 protein
3.31
up
0.01155

H93652
2039
ribosomal protein S5
3.31
up
0.00788

T33508
3105
phosphatidylinositol-4-phosphate 5-kinase, type II, beta
3.31
up
0.00416

M33197
2337
glyceraldehyde-3-phosphate dehydrogenase
3.31
up
0.00009

H59617
1964
EST
3.3
up
0.04588

D51287
1680
ribosomal protein S12
3.3
up
0.02829

L20941
2174
ferritin, heavy polypeptide 1
3.3
up
0.01172

M91083
2418
chromosome 11 open reading frame 13
3.3
up
0.00163

Z68228
3944
junction plakoglobin
3.3
up
0.0237

R73565
2958
EST
3.29
up
0.03489

Z39200
3899
EST
3.29
up
0.00586

AA084921
182
ribosomal protein S10
3.29
up
0.04872

T59668
3159
lysyl oxidase
3.28
up
0.00588

AA280928
642
EST
3.27
up
0.04625

AA397916
784
EST
3.27
up
0.02895

D20464
1625
bromodomain adjacent to zinc finger domain, 2B
3.27
up
0.04897

N73846
2679
EST
3.27
up
0.00012

080237
1729
actin related protein 2/3 complex, subunit 4 (20 kD)
3.27
up
0.00137

T47032
3123
partner of RAC1 (arfaptin 2)
3.27
up
0.00503

AA218663
444
acid-inducible phosphoprotein
3.26
up
0.03537

T25725
3090
EST
3.26
up
0.00099

X56932
3737
ribosomal protein L13a
3.26
up
0

AA040465
95
EST
3.25
up
0.00146

N62819
2594
EST
3.25
up
0.01137

X51466
3717
eukaryotic translation elongation factor 2
3.25
up
0.00019

AA459961
1223
EST
3.24
up
0.00316

AA488987
1365
synaptogyrin 2
3.24
up
0.01444

F01568
1772
EST
3.24
up
0.0018

AA431776
1027
EST
3.24
up
0.01814

AA464698
1262
EST
3.24
up
0.04854

R54614
2901
EST
3.24
up
0.00526

L76200
2223
guanylate kinase 1
3.24
up
0.0097

AA126429
247
peroxisomal farnesylated protein
3.23
up
0.00478

AA405310
856
EST
3.23
up
0.00138

AA427925
982
EST
3.23
up
0.01806

AA133590
282
EST
3.23
up
0.03565

H42321
1928
ribosomal protein L18a
3.23
up
0.01102

T15903
3062
EST
3.23
up
0.01377

AA127851
257
EST
3.23
up
0.01943

R53109
2898
dimethylarginine dimethylaminohydrolase 2
3.22
up
0.00724

AA027946
60
EST
3.22
up
0.00098

AA425401
954
serine/threonine kinase 24 (Ste20, yeast homolog)
3.22
up
0.00625

AA449458
1127
EST
3.22
up
0.03098

D60811
1704
EST
3.22
up
0.0098

H96975
2057
EST
3.22
up
0.0141

D23660
1630
ribosomal protein L4
3.22
up
0.00316

HG613-HT613

ribosomal protein S12
3.22
up
0.00761

U01147
3274
active BCR-related gene
3.22
up
0.00103

R26706
2802
EST
3.21
up
0.03858

F02863
1782
EST
3.21
up
0.01039

AA406385
876
DKFZP564B0769 protein
3.21
up
0.00724

D78676
1719
EST
3.2
up
0.00635

AA447732
1105
EST
3.2
up
0.00591

AA458852
1203
KIAA0440 protein
3.2
up
0.00038

AA397906
782
DKFZP4341216 protein
3.2
up
0.00138

AA504111
1409
EST
3.2
up
0.00544

U90549
3455
high-mobility group (nonhistone chromosomal) protein 17-like 3
3.2
up
0.0401

X13956
3698
EST
3.2
up
0.00321

AA608965
1474
Hermansky-Pudlak syndrome
3.19
up
0.00204

U62392
3402
zinc finger protein 193
3.18
up
0.00269

N58463
2579
PCTAIRE protein kinase 1
3.18
up
0.00649

AA436616
1056
EST
3.18
up
0.04402

U40990
3358
potassium voltage-gated channel, KQT-like subfamily, member 1
3.18
up
0.00093

X56997
3738
ubiquitin A-52 residue ribosomal protein fusion product 1
3.18
up
0.00006

X69391
3780
ribosomal protein L6
3.18
up
0.00003

X78687
3797
sialidase 1 (lysosomal sialidase)
3.18
up
0.031

X95404
3831
cofilin 1 (non-muscle)
3.18
up
0.00104

AA258482
596
zinc finger protein
3.17
up
0.04606

NADH dehydrogenase (ubiquinone) Fe-S protein 6 (13kD) (NADH-coenzyme

AA169837
364
Q reductase)
3.17
up
0.03038

AA479945
1319
plakophilin 3
3.17
up
0.01767

AA598506
1430
KIAA0179 protein
3.17
up
0.01694

T26574
3095
catenin (cadherin-associated protein), delta 1
3.17
up
0.00828

D25216
1631
KIAA0014 gene product
3.17
up
0.02125

D25328
1633
phosphofructokinase, platelet
3.17
up
0.04925

X63527
3758
ribosomal protein L19
3.17
up
0.02488

M64716
2382
ribosomal protein S25
3.16
up
0.00039

HG1112-HT1112

EST
3.15
up
0.04958

HG2147-HT2217

mucin 3, intestinal
3.15
up
0.0026

D78361
1718
EST
3.14
up
0.00023

Z38729
3891
EST
3.13
up
0.04514

AA192755
401
EST
3.13
up
0.00442

AA194237
408
EST
3.13
up
0.00212

M31520
2328
ribosomal protein S24
3.13
up
0.00014

AA410972
888
EST
3.12
up
0.00023

D52632
1683
ribosomal protein S6
3.12
up
0.00498

HG2724-HT2820

DNA-damage-inducible transcript 3
3.12
up
0.03726

X92518
3822
high-mobility group (nonhistone chromosomal) protein isoform I-C
3.12
up
0.00638

AA402937
843
EST
3.11
up
0.00182

N64616
2610
EST
3.11
up
0.0074

H28333
1912
melanoma adhesion molecule
3.11
up
0.00172

M14949
2264
related RAS viral (r-ras) oncogene homolog
3.11
up
0.00013

U43901
3361
laminin receptor 1 (67 kD, ribosomal protein SA)
3.11
up
0.03145

HG2815-HT2931

myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
3.11
up
0.00475

X69654
3782
ribosomal protein S26
3.11
up
0.02683

AA402968
844
EST
3.1
up
0.00453

N67205
2624
EST
3.1
up
0.00626

N92915
2723
brefeldin A-inhibited guanine nucleotide-exchange protein 1
3.1
up
0.00807

D14530
1614
ribosomal protein S23
3.1
up
0.00331

M68864
2389
ORF
3.1
up
0.00603

U14973
3307
ribosomal protein S29
3.1
up
0.00028

M36072
2347
ribosomal protein L7a
3.1
up
0.00006

AA449479
1129
EST
3.09
up
0.03495

D59847
1701
EST
3.09
up
0.02206

AA194724
409
endonuclease G
3.09
up
0.04011

AA412403
900
EST
3.09
up
0.00047

U05875
3285
interferon gamma receptor 2 (interferon gamma transducer 1)
3.09
up
0.00549

X80822
3805
ribosomal protein L18a
3.08
up
0.02481

T58153
3153
heatshock 105kD
3.08
up
0.01317

HG4319-HT4589

ribosomal protein L5
3.08
up
0.0017

U67171
3408
selenoprotein W, 1
3.08
up
0.0047

L12711
2161
transketolase (Wernicke-Korsakoff syndrome)
3.08
up
0.03362

N70577
2658
EST
3.07
up
0.01975

Z39930
3911
EST
3.07
up
0.00002

AA158795
352
EST
3.07
up
0.00057

W37937

EST
3.07
up
0.00776

D79205
1721
ribosomal protein L39
3.07
up
0.00021

AA449475
1128
EST
3.06
up
0.00291

N24899
2460
EST
3.06
up
0.00353

Z38150
3880
EST
3.06
up
0.00049

AA172076
369
EST
3.06
up
0.00326

N90238
2711
EST
3.06
up
0.00354

fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group

U27328
3337
included)
3.05
up
0.03224

AA421638
935
EST
3.05
up
0.00487

AA007158
15
EST
3.05
up
0.01964

H24077
1900
EST
3.05
up
0.0324

U36341
3350
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
3.05
up
0.02622

U02493
3278
non-Pou domain-containing octamer (ATGCAAAT) binding p
3.04
up
0.0019

N36432
2506
erythrocyte membrane protein band 4.1-like 2
3.03
up
0.03086

AA436473
1052
EST
3.03
up
0.00133

AA598712
1436
EST
3.03
up
0.03656

AA447118
1099
EST
3.03
up
0.01702

H52673
1943
BCL2-antagonist/killer 1
3.03
up
0.0393

AA491223
1389
EST
3.03
up
0.00557

T47969
3127
ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
3.03
up
0.03452

X03453
3674
EST
3.03
up
0.0025

J03459
2093
leukotriene A4 hydrolase
3.03
up
0.04041

M86667
2410
nucleosome assembly protein 1-like 1
3.03
up
0.04853

X80198
3804
steroidogenic acute regulatory protein related
3.03
up
0.00044

W44733
3516
EST
3.02
up
0.00097

X63629
3759
cadherin 3, P-cadherin (placental)
3.02
up
0.01654

AA427946
983
dynein, axonemal, light polypeptide 4
3.01
up
0.00001

R45698
2865
EST
3.01
up
0.04766

W49661
3536
FK506-binding protein 9 (63 kD)
3.01
up
0.02259

R06986
2775
peptidylprolyl isomerase B (cyclophilin B)
3.01
up
0.04418

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting

W72861
3583
protein (liprin), alpha 3
3.01
up
0.00055

AA278838
620
EST
3
up
0.02832

U03891
3282
phorbolin (similar to apolipoprotein B mRNA editing protein)
3
up
0.00065

[0133]

9

TABLE 6B

Down in Metastatics vs Normal Sample Set 2

Fragment Name
SEQ ID:
Known Gene Name
Fold Change
Direction
Pvalue

N54417
2566
fibrinogen, A alpha polypeptide
99.28
down
0.00001

N53031
2555
UDP glycosyltransferase 2 family, polypeptide B4
97.58
down
0.00022

M15656
2268
aldolase B, fructose-bisphosphate
96.66
down
0

T73442
3212
EST
94.41
down
0

T59148
3157
carbamoyl-phosphate synthetase 1, mitochondrial
88.89
down
0

R49459
2881
transferrin receptor 2
85.61
down
0.00048

X55283
3731
asialoglycoprotein receptor 2
84.99
down
0.00084

cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),

L16883
2166
polypeptide 9
84.71
down
0.00327

T48039
3128
protein C (inactivator of coagulation factors Va and VIIIa)
84.39
down
0.00112

T71373
3202
EST
83.08
down
0.00069

H58692
1960
formyltetrahydrofolate dehydrogenase
81.41
down
0

T46901
3122
EST
77.28
down
0.0006

M81349
2404
serum amyloid A4, constitutive
76.15
down
0.00015

R43174
2847
paraoxonase 1
74.04
down
0.00038

X65727
3765
glutathione S-transferase A2,glutathione S-transferase A3
73.64
down
0

M16594
2272
glutathione S-transferase A2
73.21
down
0

cytochrome P450, subfamily IIA (phenobarbital-inducible),

U22029
3326
polypeptide 7
71.98
down
0

AA256367
579
paraoxonase 3
70.33
down
0.00192

cytochrome P450, subfamily IIA (phenobarbital-inducible),

K03192
2127
polypeptide 6
69.92
down
0

AA035245
79
aldehyde oxidase 1
69.82
down
0.00117

N80129
2702
metallothionein 1L
66.48
down
0.00415

cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase),

R97419
3003
polypeptide 1
65.07
down
0.0039

T83356
3231
apolipoprotein H (beta-2-glycoprotein I)
64.34
down
0.00802

fatty-acid-Coenzyme A ligase, long-chain 1,fatty-acid-Coenzyme A

AA348922
758
ligase, long-chain 2
64.27
down
0.00002

T83397
3232
phytanoyl-CoA hydroxylase (Refsum disease)
63.6
down
0

R16098
2792
EST
63.41
down
0.00038

R89811
2979
HGF activator
62.51
down
0.00148

H57166
1955
EST
60.76
down
0.00007

N33009
2491
apolipoprotein E
60.54
down
0.0093

N54053
2560
secreted phosphoprotein 2, 24kD
60.39
down
0.00087

T68878
3190
carboxylesterase 1 (monocyte/macrophage serine esterase 1)
60.35
down
0.00409

R08564
2779
plasminogen-like
60.18
down
0.00091

F10182
1812
hepsin (transmembrane protease, serine 1)
58.92
down
0.00837

L25880
2184
epoxide hydrolase 1, microsomal (xenobiotic)
58.7
down
0.00013

W88946
3636
putative glycine-N-acyltransferase
58.26
down
0

N54429
2567
EST
57.81
down
0.00724

M29873
2318
cytochrome P450, subfamily IIB (phenobarbital-inducible)
56.71
down
0.0054

AA476324
1281
EST
55.22
down
0.00132

R12472
2788
EST
55.18
down
0.00011

AA453988
1160
methionine adenosyltransferase I, alpha
54.29
down
0.00381

T56264
3148
apolipoprotein C-II
53.04
down
0.00938

W92148
3647
kininogen
51.09
down
0.00376

R01023
2751
glucokinase (hexokinase 4) regulatory protein
50.71
down
0.00321

H80901
2005
ficolin (collagen/fibrinogen domain-containing) 3 (Hakata antigen)
50.61
down
0.00262

D31628
1646
4-hydroxyphenylpyruvate dioxygenase
50.48
down
0.00002

AA401562
830
EST
50.45
down
0.00301

cytochrome P450, subfamily IIA (phenobarbital-inducible),

K03192
2127
polypeptide 6
50.16
down
0

T67931
3183
fibrinogen, B beta polypeptide
49.55
down
0

M16974
2277
complement component 8, alpha polypeptide
49.47
down
0.00046

alcohol dehydrogenase 1 (class I), alpha polypeptide,alcohol

dehydrogenase 2 (class I), beta polypeptide,alcohol dehydrogenase

M12963
2248
3 (class I), gamma polypeptide
48.95
down
0.00104

T73433
3211
angiotensinogen
48.3
down
0.00049

AA009719
20
peroxisomal membrane protein 2 (22kD)
47.12
down
0.00008

H94666
2045
alpha-1-B glycoprotein
47.03
down
0.01158

T98676
3268
EST
46.94
down
0.0001

T40936
3117
EST
46.92
down
0.00056

R98073
3008
EST
46.87
down
0

AA456311
1190
EST
46.81
down
0.001

H91325
2029
aldolase B, frutose-bisphosphate
45.85
down
0.00505

H74317
1997
apolipoprotein A-II
45.09
down
0.01982

vitronectin (serum spreading factor, somatomedin B, complement S-

T61373
3162
protein)
44.9
down
0.3172

X16260
3707
inter-alpha (globulin) inhibitor, H1 polypeptide
44.65
down
0.00933

AA421049
927
activating transcription factor 5
44.41
down
0.00179

M17262
2278
coagulation factor II (thrombin)
44.3
down
0.00345

cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),

polypeptide 18,cytochrome P450, subfamily IIC (mephenytoin 4-

HG1827-HT1856

hydroxylase), polypeptide 8
44.17
down
0.0003

AA417046
915
fatty-acid-Coenzyme A ligase, very long-chain 1
44
down
0

AA433946
1033
EST
43.74
down
0.00005

T71012
3200
fibrinogen, B beta polypeptide
43.61
down
0.00743

L11244
2155
complement component 4-binding protein, beta
43.33
down
0

AA018867
39
EST
42.87
down
0.00002

T23882
3084
kininogen
42.85
down
0.00641

L00190
2130
antithrombin III
42.41
down
0.00012

N68596
2635
betaine-homocysteine methyltransferase
40.99
down
0

H94475
2043
alpha-2-plasmin inhibitor
40.92
down
0.00271

AA085987
183
UDP glycosyltransferase 1
40.87
down
0.00004

M75106
2396
carboxypeptidase B2 (plasma)
40.63
down
0

HG2841-HT2968

albumin
40.5
down
0.001

M58600
2362
heparin cofactor II
39.79
down
0.00034

R37128
2826
complement component 4A
39.51
down
0.00364

R93776
2992
EST
39.32
down
0.00176

cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),

M61855
2371
polypeptide 9
38.82
down
0.00023

cytochrome P450, subfamily IIA (phenobarbital-inducible),

X13930
3697
polypeptide 6
38.52
down
0

T95813
3261
KIAA1051 protein
38.38
down
0.00008

X68679
3776
complement factor H related 3,complement factor H-related 4
38.22
down
0.00036

W20094
3476
DKFZP586A0522 protein
38.09
down
0.00188

AA479148
1311
EST
38.05
down
0

AA235310
496
EST
37.86
down
0.00091

T68711
3187
EST
37.65
down
0.00036

R40395
2840
lecithin-cholesterol acyltransferase
37.33
down
0.00032

W28944
3493
EST
37.07
down
0.00205

U50929
3379
betaine-homocysteine methyltransferase
36.91
down
0

L04751
2138
cytochrome P450, subfamily IVA, polypeptide 11
36.79
down
0.00004

N76012
2693
EST
36.71
down
0.00598

T69284
3195
mannose-binding lectin (protein C) 2, soluble (opsonic defect)
36.53
down
0

R49602
2884
EST
36.5
down
0.00001

cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -

X07618
3688
metabolising), polypeptide 7a (pseudogene)
35.79
down
0.00065

N22938
2452
serum amyloid A4, constitutive
35.39
down
0.00128

AA621131
1513
EST
35.37
down
0

cytochrome P450, subfamily IVF, polypeptide 2,cytochrome P450,

D12620
1601
subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase)
35.09
down
0.00015

N70358
2656
growth hormone receptor
34.35
down
0

solute carrier family 10 (sodium/bile acid cotransporter family),

N70966
2662
member 1
34.06
down
0.0006

T68855
3188
EST
34.04
down
0

T69029
3193
haptoglobin
33.18
down
0.02825

cytochrome P450, subfamily IIA (phenobarbital-inducible),

M33317
2338
polypeptide 7
32.63
down
0

T48075
3129
hemoglobin, alpha 1
32.56
down
0.00172

alcohol dehydrogenase 1 (class I), alpha polypeptide,alcohol

dehydrogenase 2 (class I), beta polypeptide,alcohol dehydrogenase

M12272
2243
3 (class I), gamma polypeptide
32.42
down
0.0034

AA620556
1505
EST
32.4
down
0.00353

T74542
3214
UDP glycosyltransferase 2 family, polypeptide B10
32.36
down
0.00004

T56281
3150
RNA helicase-related protein
32.34
down
0.00002

W73601
3589
EST
32.25
down
0

M11567
2239
angiogenin, ribonuclease, RNase A family, 5
32.25
down
0.0001

W86600
3625
EST
32.14
down
0

AA039335
89
coagulation factor XII (Hageman factor)
32
down
0.0029

T67705
3182
asialoglycoprotein receptor 2
31.6
down
0.00705

H89980
2026
protein phosphatase 1, regulatory (inhibitor) subunit 5
31.13
down
0.00006

H20543
1897
DKFZP586B1621 protein
31.03
down
0.00074

H57060
1954
EST
30.98
down
0.01687

W67564
3568
nuclear receptor subfamily 0, group B, member 2
30.34
down
0

N74422
2685
EST
30.32
down
0

X07173
3687
inter-alpha (globulin) inhibitor, H2 polypeptide
30.3
down
0.00016

T47778
3126
fibrinogen, A alpha polypeptide
30
down
0.01401

X90579
3816
EST
29.82
down
0.00273

T99636
3270
complement component 3
29.6
down
0.00051

Z20777
3863
EST
29.59
down
0.00044

U56814
3392
deoxyribonuclease I-like 3
29.43
down
0.00003

M19828
2287
apolipoprotein B (including Ag(x) antigen)
29.37
down
0.00137

R77628
2965
insulin induced gene 1
29.23
down
0.00122

AA452158
1141
ras homolog gene family, member B
28.96
down
0.00064

coagulation factor IX (plasma thromboplastic component, Christmas

K02402
2125
disease, hemophilia B)
28.81
down
0.00001

T57140
3151
paraoxonase 3
28.8
down
0

T68873
3189
metallothionein 1L
28.72
down
0.02953

H95569
2051
DKFZP586A0522 protein
28.48
down
0.00139

T56279
3149
H factor (complement)-like 3
28.39
down
0.00016

N66066
2612
EST
28.35
down
0.00055

X07732
3690
hepsin (transmembrane protease, serine 1)
28.21
down
0

AA253216
561
EST
28.18
down
0.00141

W79046
3599
peroxisomal D3,D2-enoyl-CoA isomerase
27.9
down
0.00023

U51010
3380
nicotinamide N-methyltransferase
27.79
down
0.00366

H08102
1858
breast cell glutaminase
27.77
down
0.00032

U70732
3414
glutamic-pyruvate transaminase (alanine aminotransferase)
27.63
down
0

HG2730-HT2828

fibrinogen, A alpha polypeptide
27.34
down
0.001

D90282
1769
carbamoyl-phosphate synthetase 1, mitochondrial
27.29
down
0.00002

X53595
3726
apolipoprotein H (beta-2-glycoprotein I)
27.28
down
0.0066

AA599937
1458
insulin-like growth factor-binding protein 4
26.92
down
0.00094

L25878
2183
epoxide hydrolase 1, microsomal (xenobiotic)
26.84
down
0

Z30425
3875
nuclear receptor subfamily 1, group I, member 3
26.64
down
0

X16260
3707
inter-alpha (globulin) inhibitor, H1 polypeptide
26.39
down
0.0004

R92475
2986
flavin containing monooxygenase 3
26.13
down
0

T61649
3164
superoxide dismutase 2, mitochondrial
26.09
down
0.00734

N63845
2604
phytanoyl-CoA hydroxylase (Refsum disease)
25.92
down
0.00084

vitronectin (serum spreading factor, somatomedin B, complement S-

X03168
3671
protein)
25.88
down
0.00911

H81070
2006
RNA helicase-related protein
25.74
down
0.0126

T61801
3166
hemopexin
25.7
down
0.01362

L47726
2219
phenylalanine hydroxylase
25.63
down
0.00019

N59550
2587
EST
25.56
down
0.00024

X56411
3734
alcohol dehydrogenase 4 (class II), pi polypeptide
25.14
down
0.00144

HG2730-HT2827

fibrinogen, A alpha polypeptide
25.1
down
0

AA448300
1116
FXYD domain-containing ion transport regulator 1 (phospholemman)
24.97
down
0.00001

N39201
2509
protease inhibitor 4 (kallistatin)
24.91
down
0.00253

M34276
2341
plasminogen
24.73
down
0.00031

aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-

Z28339
3872
beta-reductase)
24.66
down
0

W72044
3577
insulin induced gene 1
24.58
down
0.00001

AA232114
463
epoxide hydrolase 2, cytoplasmic
24.34
down
0.00007

U06641
3286
UDP glycosyltransferase 2 family, polypeptide B15
24.32
down
0.00001

H93381
2036
EST
24.23
down
0

aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-

alpha hydroxysteroid dehydrogenase, type I; dihydrodiol

S68287
3024
dehydrogenase 4)
24.11
down
0

F04611
1792
EST
23.96
down
0.00018

M10058
2230
asialoglycoprotein receptor 1
23.96
down
0

L32179
2193
arylacetamide deacetylase (esterase)
23.83
down
0

AA598419
1427
translational inhibitor protein p14.5
23.6
down
0.00036

F02028
1774
EST
23.48
down
0.00465

N89302
2707
HLA-B associated transcript-3
23.44
down
0.00192

AA279676
630
deoxyribonuclease I-like 3
23.35
down
0.00001

aldo-keto reductase family 1, member C1 (dihydrodiol

dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid

U05861
3284
dehydrogenase)
23.22
down
0.00002

H09353
1866
EST
23.06
down
0.00094

M93405
2423
methylmalonate-semialdehyde dehydrogenase
23.06
down
0

S48983
3017
serum amyloid A4, constitutive
23.04
down
0.00022

AA443936
1084
EST
22.96
down
0.00627

N74025
2684
deiodinase, iodothyronine, type I
22.79
down
0

M15517
2267
EST
22.76
down
0.03365

M16973
2276
complement component 8, beta polypeptide
22.75
down
0.00001

X86401
3812
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
22.7
down
0

D16626
1622
histidine ammonia-lyase
22.66
down
0

J02843
2088
cytochrome P450, subfamily IIE (ethanol-inducible)
22.58
down
0.00935

U22961
3329
albumin
22.22
down
0.01531

AA486511
1349
EST
22.21
down
0.00113

L48516
2220
paraoxonase 3
22.21
down
0.00004

M62486
2374
complement component 4-binding protein, alpha
22.08
down
0.00272

cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide

D00003
1586
3
22.05
down
0.00059

J03810
2099
solute carrier family 2 (facilitated glucose transporter), member 2
21.99
down
0.00004

AA219304
447
alpha-2-macroglobulin
21.97
down
0.00011

R08615
2780
homogentisate 1,2-dioxygenase (homogentisate oxidase)
21.85
down
0.00026

AA147646
317
DKFZP586A0522 protein
21.82
down
0

AA292158
706
EST
21.79
down
0.00031

D11835
1598
low density lipoprotein receptor (familial hypercholesterolemia)
21.76
down
0.00307

T87174
3239
EST
21.71
down
0.00681

M16961
2274
alpha-2-HS-glycoprotein
21.45
down
0.01175

D78011
1717
dihydropyrimidinase
21.37
down
0.00003

R98624
3012
EST
21.32
down
0

R65593
2934
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
21.27
down
0.00007

K02766
2126
complement component 9
21.24
down
0

AA171694
366
ceruloplasmin (ferroxidase)
21.23
down
0.00179

T58775
3156
small inducible cytokine subfamily A (Cys-Cys), member 16
21.18
down
0.00006

N71542
2664
kidney- and liver-specific gene
21.05
down
0

AA343142
751
EST
20.87
down
0.00003

X12662
3694
arginase, liver
20.59
down
0

R64131
2929
EST
20.58
down
0.01028

M68516
2387
protein C inhibitor (plasminogen activator inhibitor III)
20.54
down
0

L07765
2147
carboxylesterase 1 (monocyte/macrophage serine esterase 1)
20.53
down
0.00025

D10040
1593
fatty-acid-Coenzyme A ligase, long-chain 2
20.51
down
0

D13243
1602
pyruvate kinase, liver and RBC
20.22
down
0

X01038
3666
apolipoprotein A-I,apolipoprotein C-III
19.97
down
0.0275

T78889
3220
fibronectin 1
19.87
down
0.00912

S95936
3040
transferrin
19.76
down
0.02009

R59722
2915
EST
19.74
down
0.00016

U08198
3291
complement component 8, gamma polypeptide
19.71
down
0

AA148480
318
flavin containing monooxygenase 5
19.64
down
0

M83772
2408
flavin containing monooxygenase 3
19.54
down
0

X03350
3673
alcohol dehydrogenase 2 (class I), beta polypeptide
19.32
down
0.00001

W86375
3623
EST
19.29
down
0.0061

M76665
2397
hydroxysteroid (11-beta) dehydrogenase 1
19.22
down
0.00004

J02943
2090
corticosteroid binding globulin
18.98
down
0.00087

T61389
3163
haptoglobin
18.95
down
0.04873

J04093
2106
UDP glycosyltransferase 1
18.92
down
0

Y09616
3854
carboxylesterase 2 (intestine, liver)
18.78
down
0.00026

Z40715
3920
delta-6 fatty acid desaturase
18.68
down
0.0007

M13149
2250
histidine-rich glycoprotein
18.65
down
0.02974

U32576
3346
apolipoprotein C-IV
18.59
down
0.00005

X00129
3664
retinol-binding protein 4, interstitial
18.57
down
0.02378

N69136
2644
EST
18.53
down
0.00366

Z49269
3942
small inducible cytokine subfamily A (Cys-Cys), member 14
18.46
down
0.00001

M29874
2319
cytochrome P450, subfamily IIB (phenobarbital-inducible)
18.44
down
0.00081

M11437
2238
kininogen
18.38
down
0.00006

Y00317
3842
UDP glycosyltransferase 2 family, polypeptide B4
18.34
down
0.00001

fatty-acid-Coenzyme A ligase, long-chain 1,fatty-acid-Coenzyme A

L09229
2150
ligase, long-chain 2
18.34
down
0.00016

macrophage stimulating 1 (hepatocyte growth factor-

U37055
3352
like),macrophage stimulating, pseudogene 9
18.28
down
0

S68805
3025
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
18.19
down
0.00083

D49742
1668
hyaluronan-binding protein 2
18.13
down
0.00012

N49090
2532
EST
18
down
0.00501

M20867
2291
glutamate dehydrogenase 1
17.73
down
0.00002

AA435985
1049
EST
17.7
down
0

X95384
3830
translational inhibitor protein p14.5
17.69
down
0.00048

solute carrier family 22 (extraneuronal monoamine transporter),

T51617
3137
member 3
17.67
down
0.00018

D59714
1700
mitogen inducible 2
17.62
down
0.00014

M11025
2235
asialoglycoprotein receptor 2
17.56
down
0.00003

M86873
2413
plasminogen,plasminogen-like
17.54
down
0

AA292328
707
activating transcription factor 5
17.51
down
0.00689

HG1148-HT1148

EST
17.51
down
0.00024

D62518
1708
EST
17.49
down
0.00017

AA424798
947
EST
17.45
down
0.00352

L32140
2192
afamin
17.31
down
0.00003

glucose-6-phosphatase, catalytic (glycogen storage disease type I,

R02365
2754
von Gierke disease)
17.17
down
0.00124

N54950
2572
ketohexokinase (fructokinase)
17.17
down
0.00078

M10612
2232
apolipoprotein C-II
17.13
down
0.00746

H30270
1915
EST
17.09
down
0.00001

N73543
2674
EST
17
down
0.00003

M20786
2290
alpha-2-plasmin inhibitor
16.95
down
0.00709

U20530
3321
secreted phosphoprotein 2, 24kD
16.93
down
0

Z39833
3910
GTP-binding protein
16.89
down
0.00034

AA377087
771
EST
16.75
down
0.00002

H47838
1936
carboxypeptidase B2 (plasma)
16.74
down
0.00002

D00097
1588
amyloid P component, serum
16.72
down
0.00098

AA236401
510
EST
16.71
down
0.00088

T52813
3141
putative lymphocyte G0/G1 switch gene
16.71
down
0.03897

W92713
3651
EST
16.55
down
0.00097

H83109
2012
EST
16.55
down
0.00001

T63490
3170
EST
16.54
down
0

AA122345
238
glutamate dehydrogenase 1
16.53
down
0.00004

M11321
2237
group-specific component (vitamin D binding protein)
16.52
down
0.01416

K02215
2124
angiotensinogen
16.51
down
0.00006

AA449267
1120
EST
16.44
down
0.00926

N68974
2639
EST
16.44
down
0.00087

R43799
2850
EST
16.35
down
0.00208

N51773
2548
EST
16.32
down
0.0007

L11005
2154
aldehyde oxidase 1
16.3
down
0.00065

N71935
2666
multiple PDZ domain protein
16.28
down
0

M26393
2309
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain
16.27
down
0.00007

J05037
2116
serine dehydratase
16.24
down
0.00015

M11437
2238
kininogen
16.19
down
0.02277

alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I;

T73739
3213
glycolicaciduria; serine-pyruvate aminotransferase)
16.18
down
0.00277

AA404252
848
lectin, mannose-binding, 1
16.15
down
0.00001

M58569
2361
EST
16.15
down
0.00174

J05428
2120
UDP glycosyltransferase 2 family, polypeptide B7
16.14
down
0.00563

AA194997
412
EST
16.12
down
0.00103

X14690
3700
pre-alpha (globulin) inhibitor, H3 polypeptide
16.07
down
0.00438

H77597
2000
metallothionein 1H
16.03
down
0.00675

U08006
3289
complement component 8, alpha polypeptide
16
down
0.00111

AA458946
1209
EST
15.88
down
0.00004

M13699
2253
ceruloplasmin (ferroxidase)
15.85
down
0.00012

M21642
2294
antithrombin III
15.82
down
0.01027

W28824
3492
EST
15.8
down
0.00006

H60595
1966
progesterone binding protein
15.8
down
0.01078

R06746
2770
EST
15.77
down
0.00009

AA236455
512
EST
15.71
down
0.00286

AA253369
563
EST
15.59
down
0.00091

AA479885
1318
KIAA0843 protein
15.57
down
0.00024

butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-

AA455988
1184
butyrobetaine hydroxylase)
15.54
down
0.00001

AA381125
772
EST
15.48
down
0

AA455403
1177
EST
15.46
down
0.01547

U29953
3341
pigment epithelium-derived factor
15.33
down
0.00212

AA456289
1189
EST
15.31
down
0.00004

H93246
2035
EST
15.3
down
0.00233

AA015768
34
EST
15.3
down
0.00008

AA195656
418
KIAA0977 protein
15.29
down
0.00817

M21642
2294
antithrombin III
15.23
down
0.02088

X56692
3736
C-reactive protein, pentraxin-related
15.15
down
0.01884

AA196287
420
EST
15.07
down
0.00001

T48278
3131
EST
15.04
down
0.04751

N66857
2619
EST
15.03
down
0.00005

AA156565
344
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like 1
15.01
down
0.01387

N58326
2578
EST
14.97
down
0.00647

W86431
3624
protein C inhibitor (plasminogen activator inhibitor III)
14.94
down
0.00152

W79422
3601
fumarylacetoacetate
14.94
down
0.00059

H58673
1959
EST
14.85
down
0.00005

Y12711
3858
progesterone binding protein
14.83
down
0.00285

N31741
2488
serine hydroxymethyltransferase 1 (soluble)
14.76
down
0.00001

N57464
2575
CCAAT/enhancer binding protein (C/EBP), delta
14.69
down
0.00018

X64877
3763
H factor (complement)-like 3
14.6
down
0

aldehyde dehydrogenase 4 (glutamate gamma-semialdehyde

U24266
3330
dehydrogenase; pyrroline-5-carboxylate dehydrogenase)
14.54
down
0

N91882
2719
alpha2,3-sialyltransferase
14.52
down
0.00024

AA402224
836
growth arrest and DNA-damage-inducible, gamma
14.41
down
0.00012

AA179004
377
EST
14.34
down
0.00008

AA034030
75
methylmalonyl Coenzyme A mutase
14.32
down
0.00004

M17262
2278
coagulation factor II (thrombin)
14.24
down
0.00028

U48707
3370
protein phosphatase 1, regulatory (inhibitor) subunit 1A
14.22
down
0

glutamate-cysteine ligase (gamma-glutamylcysteine synthetase),

L35546
2203
regulatory (30.8kD)
14.18
down
0.00018

T74608
3215
hydroxyacid oxidase (glycolate oxidase) 1
14.03
down
0

U95090
3463
nephrosis 1, congenital, Finnish type (nephrin)
14.01
down
0.00018

AA092716
198
HLA-B associated transcript-3
13.97
down
0.00009

D20350
1624
EST
13.97
down
0.00057

Z49878
3943
guanidinoacetate N-methyltransferase
13.96
down
0.00021

HG1428-HT1428

hemoglobin, beta
13.89
down
0.01109

alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I;

X53414
3725
glycolicaciduria; serine-pyruvate aminotransferase)
13.87
down
0.00003

M57731
2359
GRO2 oncogene
13.87
down
0.0123

Z48475
3940
glucokinase (hexokinase 4) regulatory protein
13.84
down
0

W86075
3621
EST
13.83
down
0.00057

N57934
2576
formiminotransferase cyclodeaminase
13.81
down
0.00171

AF000573
1543
homogentisate 1,2-dioxygenase (homogentisate oxidase)
13.76
down
0.00002

R36989
2825
hypothetical protein, estradiol-induced
13.7
down
0.00056

macrophage stimulating 1 (hepatocyte growth factor-

N78850
2698
like),macrophage stimulating, pseudogene 9
13.69
down
0.00421

X63359
3756
UDP glycosyltransferase 2 family, polypeptide B10
13.66
down
0.00051

N80129
2702
metallothionein 1L
13.6
down
0.00196

T61256
3161
ketohexokinase (fructokinase)
13.59
down
0.00425

cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -

X07618
3688
metabolising), polypeptide 7a (pseudogene)
13.58
down
0

HG2383-HT4824

cystathionine-beta-synthase
13.57
down
0.00035

X52520
3720
tyrosine aminotransferase
13.51
down
0.00002

X98337
3837
complement factor H related 3,complement factor H-related 4
13.5
down
0.00001

T17411
3077
transthyretin (prealbumin, amyloidosis type I)
13.49
down
0.00203

cytochrome P450, subfamily IVF, polypeptide 2,cytochrome P450,

D12620
1601
subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase)
13.45
down
0

N75870
2692
dual specificity phosphatase 1
13.41
down
0.00251

glucose-6-phosphatase, catalytic (glycogen storage disease type I,

U01120
3273
von Gierke disease)
13.41
down
0.00147

T58756
3155
EST
13.39
down
0.00013

AA470153
1275
solute carrier family 21 (organic anion transporter), member 9
13.26
down
0.00315

T40995
3118
alcohol dehydrogenase 3 (class I), gamma polypeptide
13.25
down
0.01531

R92768
2988
EST
13.2
down
0.00001

AA148923
321
decidual protein induced by progesterone
13.2
down
0.00257

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive

D38535
1654
glycoprotein)
13.2
down
0.01165

solute carrier family 10 (sodium/bile acid cotransporter family),

L21893
2176
member 1
13.18
down
0.00155

AA259064
602
EST
13.15
down
0.00001

N73561
2675
EST
12.96
down
0.00011

X59766
3746
alpha-2-glycoprotein 1, zinc
12.96
down
0.00043

AA233152
467
EST
12.95
down
0

X72177
3787
complement component 6
12.94
down
0.00011

Z40902
3923
SEC14 (S. cerevisiae)-like 2
12.87
down
0.00001

X95190
3829
acyl-Coenzyme A oxidase 2, branched chain
12.81
down
0

R52822
2895
EST
12.79
down
0.00001

W95041
3659
EST
12.79
down
0.00001

X13334
3696
CD14 antigen
12.77
down
0.00887

D14012
1612
HGF activator
12.75
down
0.0035

L12760
2162
phosphoenolpyruvate carboxykinase 1 (soluble)
12.75
down
0.00035

R08850
2781
EST
12.55
down
0.00009

AA608546
1463
EST
12.52
down
0.00003

AA398280
792
EST
12.43
down
0.00134

J03910
2101
EST
12.42
down
0.01167

AA599814
1456
EST
12.37
down
0.00002

W87532
3631
putative glycine-N-acyltransferase
12.34
down
0.00014

M14338
2260
protein S (alpha)
12.33
down
0

X64877
3763
H factor (complement)-like 3
12.33
down
0

R80048
2971
EST
12.28
down
0.00128

R06726
2769
protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin
12.26
down
0.03905

AA405832
866
EST
12.24
down
0.00441

M29194
2315
lipase, hepatic
12.18
down
0.00012

W58756
3551
EST
12.17
down
0.00087

T24106
3088
EST
12.13
down
0.01687

AA402656
841
EST
12.05
down
0.00001

L11244
2155
complement component 4-binding protein, beta
12.03
down
0.0001

M65134
2385
complement component 5
12.01
down
0.00012

HG3543-HT3739

insulin-like growth factor 2 (somatomedin A)
11.97
down
0.00221

bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-

L34081
2199
choloyltransferase)
11.96
down
0.00008

U77594
3427
retinoic acid receptor responder (tazarotene induced) 2
11.95
down
0.00527

AA400258
812
EST
11.89
down
0.00478

AA402799
842
EST
11.81
down
0.00031

M94065
2424
dihydroorotate dehydrogenase
11.78
down
0.00034

U76376
3424
harakiri, BCL2-interacting protein (contains only BH3 domain)
11.77
down
0.00002

AA090257
190
superoxide dismutase 2, mitochondrial
11.72
down
0.02072

AA021623
43
insulin induced gene 1
11.71
down
0.00094

W70115
3573
histidine ammonia-lyase
11.65
down
0.0003

M69177
2391
monoamine oxidase B
11.64
down
0.00001

acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-

X14813
3702
Coenzyme A thiolase)
11.61
down
0.0002

AA461444
1239
EST
11.56
down
0.00167

R73816
2960
EST
11.53
down
0.00259

U31449
3344
transmembrane 4 superfamily member 4
11.53
down
0.00187

H55759
1949
EST
11.52
down
0.00034

U27460
3338
UDP-glucose pyrophosphorylase 2
11.46
down
0.00088

H29568
1914
EST
11.45
down
0.00058

AA194833
411
claudin 1
11.45
down
0.00034

AA176233
376
EST
11.44
down
0.01856

M74587
2393
insulin-like growth factor binding protein 1
11.42
down
0.00274

AA436560
1055
claudin 1
11.41
down
0.00756

Z69923
3945
HGF activator
11.37
down
0.00053

U56814
3392
deoxyribonuclease I-like 3
11.36
down
0.00001

AA236455
512
EST
11.35
down
0.02859

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-

U13061
3301
preferring, member 1
11.32
down
0.00048

D49357
1665
methionine adenosyltransferase I, alpha
11.28
down
0.00331

X04085
3675
catalase
11.27
down
0.0002

M31994
2332
aldehyde dehydrogenase 1, soluble
11.24
down
0.01192

R10287
2784
EST
11.2
down
0.0003

Z31357
3877
cysteine dioxygenase, type I
11.2
down
0.0001

T86482
3237
transferrin
11.15
down
0.00006

cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide

3,cytochrome P450, subfamily IIIA (niphedipine oxidase),

D00408
1589
polypeptide 5,cytochrome P450, subfamily IIIA, polypeptide 7
11.1
down
0

AA074885
161
macrophage receptor with collagenous structure
11.05
down
0.00786

HG4533-HT4938

protease inhibitor 4 (kallistatin)
11.01
down
0.00001

H70554
1989
EST
10.99
down
0

5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate

L38928
2209
cyclo-ligase)
10.97
down
0.0267

AA182568
388
STAT induced STAT inhibitor-2
10.92
down
0.00099

X01388
3667
apolipoprotein C-III
10.9
down
0.01246

AA076326
170
SEC14 (S. cerevisiae)-like 2
10.88
down
0.00616

X06562
3683
growth hormone receptor
10.87
down
0.00001

W89178
3638
transferrin receptor 2
10.85
down
0.00116

D13643
1609
KIAA0018 gene product
10.84
down
0.00058

R62519
2925
EST
10.83
down
0.00243

AA454159
1162
EST
10.81
down
0.00132

R94674
2995
EST
10.76
down
0.00008

H12593
1880
zinc-finger protein 265
10.72
down
0.0056

H61295
1968
CD4 antigen (p55)
10.71
down
0.00925

AA489636
1370
EST
10.7
down
0

acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A

D10511
1594
thiolase)
10.68
down
0.0002

M14091
2257
thyroxin-binding globulin
10.66
down
0.0024

AA425294
952
EST
10.61
down
0.00083

AA347674
753
EST
10.59
down
0.03716

C20653
1578
EST
10.59
down
0.00001

D31815
1648
regucalcin (senescence marker protein-30)
10.55
down
0.00037

T51150
3136
EST
10.52
down
0.00377

Y00451
3845
aminolevulinate, delta-, synthase 1
10.52
down
0.00107

N67893
2628
EST
10.48
down
0.00341

T64575
3171
EST
10.46
down
0.00014

AA150776
330
EST
10.45
down
0.00015

R93714
2991
fetuin B
10.42
down
0.00043

T72171
3205
thyroxin-binding globulin
10.41
down
0.00163

S77410
3034
angiotensin receptor 1
10.4
down
0

N49595
2537
EST
10.39
down
0.00022

M13143
2249
kallikrein B plasma, (Fletcher factor) 1
10.39
down
0.00019

W90455
3643
alpha-2-macroglobulin
10.35
down
0.00063

glycine dehydrogenase (decarboxylating; glycine decarboxylase,

H11739
1876
glycine cleavage system protein P)
10.33
down
0.00023

T71776
3203
EST
10.3
down
0.00897

AA454177
1164
EST
10.3
down
0.0008

N73988
2682
EST
10.27
down
0.00083

L27050
2186
apolipoprotein F
10.26
down
0.00026

K02100
2123
ornithine carbamoyltransferase
10.24
down
0.00009

AA236365
509
3-phosphoglycerate dehydrogenase
10.23
down
0.00562

AA010750
28
calmodulin 1 (phosphorylase kinase, delta)
10.22
down
0.00959

R45656
2864
EST
10.21
down
0.00179

gap junction protein, beta 1, 32kD (connexin 32, Charcot-Marie-

X04325
3676
Tooth neuropathy, X-linked)
10.17
down
0.00061

R06002
2762
EST
10.15
down
0.00003

T82323
3230
immunoglobulin superfamily, member 4
10.14
down
0

AA017146
36
EST
10.1
down
0.00052

U32989
3347
tryptophan 2,3-dioxygenase
10.07
down
0.02825

AA035457
80
EST
10.06
down
0.00085

N89738
2709
EST
10.06
down
0.00052

N94930
2740
multiple PDZ domain protein
10.06
down
0.00226

M93143
2422
plasminogen-like
10.06
down
0.00098

AA448002
1113
putative type II membrane protein
10.05
down
0

M11313
2236
alpha-2-macroglobulin
10.05
down
0.00014

M23234
2299
ATP-binding cassette, sub-family B (MDR/TAP), member 4
10.05
down
0

W90128
3640
X-box binding protein 1
10.04
down
0.00018

AA284795
678
phosphatidylethanolamine N-methyltransferase
10.03
down
0.00019

T39897
3113
androgen induced protein
10
down
0.00466

Y00318
3843
I factor (complement)
10
down
0.00019

T51930
3138
EST
9.99
down
0.00066

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A

N64036
2606
dehydrogenase
9.99
down
0.00125

AA235873
505
H factor (complement)-like 1,H factor 1 (complement)
9.98
down
0.01667

AA421561
933
insulin-like growth factor 2 (somatomedin A)
9.98
down
0.00007

R31641
2813
EST
9.96
down
0.00011

AA490670
1379
EST
9.96
down
0.00454

N59543
2586
PDZ domain containing 1
9.96
down
0.00052

S70004
3028
glycogen synthase 2 (liver)
9.96
down
0.00001

R08548
2778
EST
9.94
down
0.00326

Z11793
3861
selenoprotein P, plasma, 1
9.94
down
0.00021

AA035638
82
EST
9.91
down
0.00541

AA223902
450
EST
9.91
down
0.00003

AA452855
1150
lectin, mannose-binding, 1
9.88
down
0.00428

AA400915
823
EST
9.84
down
0.00351

M17466
2279
coagulation factor XII (Hageman factor)
9.76
down
0.00285

W67147
3565
deleted in liver cancer 1
9.74
down
0.00002

methylenetetrahydrofolate dehydrogenase (NADP+ dependent),

methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate

H10779
1872
synthetase
9.73
down
0.00035

R98413
3011
EST
9.71
down
0.00007

N51117
2543
EST
9.68
down
0.00081

cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide

J04813
2114
5
9.67
down
0.0107

R91503
2981
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
9.64
down
0.00584

X02176
3669
complement component 9
9.61
down
0.00004

D85181
1750
sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like
9.56
down
0.00005

R99591
3015
CD5 antigen-like (scavenger receptor cysteine rich family)
9.52
down
0.00006

H56584
1951
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like 1
9.5
down
0

H94247
2041
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
9.49
down
0.02373

cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide

D00003
1586
3
9.46
down
0.00001

R67970
2939
gamma-glutamyl carboxylase
9.45
down
0.00212

N24879
2459
EST
9.44
down
0.00008

T86978
3238
glutamate dehydrogenase 1
9.44
down
0.00006

N23665
2454
hydroxysteroid (17-beta) dehydrogenase 2
9.4
down
0.00055

W42789
3512
EST
9.38
down
0.00059

U02388
3277
cytochrome P450, subfamily IVF, polypeptide 2
9.38
down
0.00001

AA039616
90
EST
9.36
down
0.00009

N73883
2681
EST
9.35
down
0

X16349
3709
sex hormone-binding globulin
9.34
down
0.00007

W61377
3559
EST
9.33
down
0.0012

H38246
1917
EST
9.25
down
0.00157

D16626
1622
histidine ammonia-lyase
9.25
down
0.00025

W87606
3632
protein Z, vitamin K-dependent plasma glycoprotein
9.23
down
0.00085

AA312946
731
EST
9.21
down
0.00106

R98074
3009
EST
9.21
down
0.00048

R64199
2932
SEC22, vesicle trafficking protein (S. cerevisiae)-like 1
9.19
down
0.00387

AA419608
925
EST
9.19
down
0.00005

AA459690
1221
EST
9.18
down
0.00732

N72695
2670
EST
9.18
down
0.00069

U49082
3372
transporter protein
9.17
down
0.00088

AA291323
699
BCL2-interacting killer (apoptosis-inducing)
9.15
down
0.00514

M25079
2305
hemoglobin, beta
9.15
down
0.01399

AA430028
1008
EST
9.14
down
0.00246

W55903
3543
adipose differentiation-related protein; adipophilin
9.12
down
0.00459

AA083812
175
DKFZP566F123 protein
9.11
down
0.00167

R40899
2843
glycine receptor, beta
9.11
down
0.0009

AA099391
207
myosin, light polypeptide kinase
9.07
down
0.00003

AA287566
690
KIAA0187 gene product
9.07
down
0.00013

AA233369
471
histidine ammonia-lyase
9.06
down
0.0008

AA443658
1079
transmembrane 7 superfamily member 2
9.06
down
0.00048

M14218
2259
argininosuccinate lyase
9.03
down
0.00078

W44745
3517
EST
9.02
down
0.00276

AA479968
1321
arylsulfatase A
9.01
down
0.00224

AA193204
402
Arg/Abl-interacting protein ArgBP2
8.98
down
0.00861

D14664
1616
KIAA0022 gene product
8.98
down
0.00011

Y00317
3842
UDP glycosyltransferase 2 family, polypeptide B4
8.97
down
0.00025

AA480975
1322
EST
8.95
down
0.00259

AA282061
652
KIAA0962 protein
8.95
down
0.01033

R32490
2817
EST
8.95
down
0.00215

R40492
2841
EST
8.89
down
0.00229

N67876
2627
insulin-like growth factor 1 (somatomedin C)
8.89
down
0.00042

T72502
3207
EST
8.87
down
0.00009

T58032
3152
3-hydroxyanthranilate 3,4-dioxygenase
8.86
down
0.00023

AA487503
1356
EST
8.85
down
0.00012

N94367
2739
EST
8.79
down
0.01003

C21130
1583
EST
8.79
down
0.00008

Z84721
3950
hemoglobin, zeta
8.77
down
0.01446

AA609537
1483
hepatic leukemia factor
8.76
down
0.00018

AA489798
1373
hypothetical protein, estradiol-induced
8.75
down
0.00544

N32071
2490
EST
8.75
down
0.00006

AA236796
517
follistatin
8.74
down
0.00862

glutamic-oxaloacetic transaminase 1, soluble (aspartate

M37400
2348
aminotransferase 1)
8.7
down
0.0004

T90520
3248
EST
8.67
down
0.00072

H59136
1962
EST
8.64
down
0.00013

T78433
3219
glycogen synthase 2 (liver)
8.62
down
0.00072

N81025
2704
EST
8.61
down
0.00015

T66189
3177
glutaryl-Coenzyme A dehydrogenase
8.61
down
0.00003

AA405819
865
KIAA0668 protein
8.59
down
0.02034

AA480991
1323
EST
8.59
down
0.00156

AA488843
1362
cornichon-like
8.58
down
0.02131

AA521292
1422
EST
8.58
down
0.00064

UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine

AA598417
1426
kinase
8.56
down
0.01638

AA010619
27
EST
8.55
down
0.00057

H95978
2052
EST
8.55
down
0.00046

AA477978
1294
short-chain dehydrogenase/reductase 1
8.53
down
0.01651

AA491001
1386
EST
8.52
down
0.01118

J05158
2117
carboxypeptidase N, polypeptide 2, 83kD
8.52
down
0

AA112101
222
EST
8.5
down
0.00004

paired basic amino acid cleaving enzyme (furin, membrane

X17094
3714
associated receptor protein)
8.5
down
0

AA101235
214
EST
8.46
down
0.00822

X54380
3727
pregnancy-zone protein
8.44
down
0.00059

AA406126
869
EST
8.43
down
0.00569

M96843
2434
EST
8.42
down
0.02394

N99542
2746
orosomucoid 1
8.41
down
0.00001

AA428325
988
EST
8.36
down
0.00002

AA430011
1006
EST
8.35
down
0.00729

AA182030
387
EST
8.32
down
0.00018

W61378
3560
EST
8.31
down
0

W03796
3467
EST
8.3
down
0.0032

X60673
3749
adenylate kinase 3
8.3
down
0.00016

F08817
1796
EST
8.29
down
0.0077

X15422
3705
mannose-binding lectin (protein C) 2, soluble (opsonic defect)
8.29
down
0.00015

AA398423
795
EST
8.26
down
0.00063

AA412063
895
EST
8.26
down
0.00001

AA458652
1202
EST
8.26
down
0.00001

AA126722
251
O-6-methylguanine-DNA methyltransferase
8.26
down
0.002

R96822
2999
EST
8.25
down
0.00008

R38709
2832
superoxide dismultase 2, mitochondrial
8.23
down
0.01578

AA397841
780
EST
8.21
down
0

Z40259
3916
EST
8.18
down
0.00002

AA125831
241
myosin, light polypeptide kinase
8.18
down
0.00039

D49387
1666
NADP dependent leukotriene b4 12-hydroxydehydrogenase
8.17
down
0.00972

M58286
2360
tumor necrosis factor receptor superfamily, member 1A
8.15
down
0.00037

W26769
3482
CGI-86 protein
8.14
down
0.00204

AA609519
1482
EST
8.13
down
0.00009

F10276
1814
dual specificity phosphatase 6
8.13
down
0.0001

R10378
2785
fibrinogen-like 1
8.13
down
0.00189

AA257057
586
EST
8.11
down
0.00379

D52097
1682
prostatic binding protein
8.1
down
0.00141

X76717
3794
metallothionein 1L
8.09
down
0.00025

AA447971
1110
EST
8.08
down
0.00035

aldehyde dehydrogenase 5 family, member A1 (succinate-

AA486410
1348
semialdehyde dehydrogenase)
8.08
down
0.00485

N34804
2496
DKFZP434J214 protein
8.08
down
0.00028

AA167565
362
EST
8.08
down
0.00046

AA234095
478
EST
8.08
down
0.00394

AA489629
1369
EST
8.08
down
0.00109

AA412481
902
EST
8.07
down
0.00014

N52271
2551
LIM protein (similar to rat protein kinase C-binding enigma)
8.06
down
0.00011

N94146
2738
EST
8.05
down
0

AA004521
8
prostate cancer overexpressed gene 1
8.03
down
0.00027

R49035
2876
EST
8.02
down
0.00991

M59815
2364
complement component 4A
8.02
down
0.00049

HG3044-HT3742

fibronectin 1
8.02
down
0.02094

AA007629
19
EST
8.01
down
0.00001

W33167
3498
EST
8.01
down
0.00026

H98771
2069
BCL2/adenovirus E1B 19kD-interacting protein 3
8
down
0.0018

AA450127
1132
growth arrest and DNA-damage-inducible, beta
7.98
down
0.00078

AA609316
1481
EGF-like-domain, multiple 5
7.97
down
0.00011

W87454
3629
homogentisate 1,2-dioxygenase (homogentisate oxidase)
7.93
down
0.00149

N63698
2603
EST
7.92
down
0.00001

Z24725
3867
mitogen inducible 2
7.9
down
0

Z30425
3875
nuclear receptor subfamily 1, group I, member 3
7.88
down
0.00006

matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD

F03969
1785
type IV collagenase)
7.87
down
0.00014

X68733
3778
alpha-1-antichymotrypsin
7.87
down
0.03266

AA599211
1445
short-chain dehydrogenase/reductase 1
7.85
down
0.00911

solute carrier family 25 (mitochondrial carrier; citrate transporter),

AA079758
174
member 1
7.83
down
0.00359

AA398124
787
growth factor receptor-bound protein 14
7.82
down
0.00009

AA416873
908
EST
7.82
down
0.00005

cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),

M61853
2369
polypeptide 18
7.82
down
0.00024

W95795
3662
EST
7.8
down
0.00359

R69417
2941
EST
7.79
down
0.03795

AA430044
1010
EST
7.78
down
0.00124

AA460449
1228
EST
7.77
down
0.00011

R73485
2957
EST
7.77
down
0.0009

W20467
3479
EST
7.76
down
0.00008

AA481432
1328
fibronectin 1
7.76
down
0.0061

L29433
2191
coagulation factor X
7.74
down
0.00244

AA261954
604
EST
7.69
down
0.00334

T16484
3070
EST
7.69
down
0.00805

AA443272
1074
EST
7.68
down
0.00869

AA282516
660
7-dehydrocholesterol reductase
7.67
down
0.0008

AA459668
1219
3-hydroxyisobutyryl-Coenzyme A hydrolase
7.62
down
0.00225

AA431773
1026
EST
7.61
down
0.00063

X92720
3823
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
7.6
down
0.00001

AA142849
306
EST
7.59
down
0.00804

W90766
3646
EST
7.58
down
0.00057

N40320
2513
EST
7.56
down
0.01584

AA410255
882
EST
7.56
down
0.00043

T72906
3209
EST
7.56
down
0.00062

M65292
2386
H factor (complement)-like 1,H factor 1 (complement)
7.56
down
0.01152

R59221
2911
progesterone binding protein
7.54
down
0.00159

N77326
2695
EST
7.51
down
0.00542

AA400864
821
EST
7.51
down
0.02237

HG2379-HT3996

serine hydroxymethyltransferase 1 (soluble)
7.49
down
0.00093

AA234634
486
CCAAT/enhancer binding protein (C/EBP), delta
7.48
down
0.03318

solute carrier family 25 (mitochondrial carrier; citrate transporter),

AA435777
1047
member 1
7.48
down
0.00613

W73889
3591
tetranectin (plasminogen-binding protein)
7.45
down
0.00091

X67491
3773
glutamate dehydrogenase 1
7.45
down
0.00019

AA292773
713
collagen, type XVIII, alpha 1
7.44
down
0.00158

U95090
3463
nephrosis 1, congenital, Finnish type (nephrin)
7.44
down
0.00004

M65131
2384
methylmalonyl Coenzyme A mutase
7.44
down
0.00004

AA398892
800
similar to yeast BET3 (S. cerevisiae)
7.43
down
0.00038

AA621274
1519
EST
7.43
down
0.00065

T72268
3206
B-factor, properdin
7.43
down
0.01197

AA010205
23
EST
7.41
down
0

R32440
2816
EST
7.41
down
0.00159

N63391
2599
EST
7.39
down
0.00565

M22976
2297
cytochrome b-5
7.39
down
0.02431

U08854
3292
UDP glycosyltransferase 2 family, polypeptide B15
7.38
down
0.00005

M12712
2246
protein C (inactivator of coagulation factors Va and VIIIa)
7.37
down
0.01866

AA256341
578
EST
7.37
down
0.00091

AA256171
575
EST
7.34
down
0.04562

AA436489
1053
EST
7.34
down
0.001

AA099225
206
EST
7.33
down
0.00062

T77729
3217
pyruvate carboxylase
7.29
down
0.00022

protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65),

AA191310
397
beta isoform
7.28
down
0

AA497052
1408
DKFZP727G051 protein
7.28
down
0.01745

W85847
3616
EST
7.28
down
0.00024

AA344866
752
complement component 8, gamma polypeptide
7.28
down
0.00206

L11931
2159
serine hydroxymethyltransferase 1 (soluble)
7.27
down
0.00041

AA429904
1005
EST
7.26
down
0.00524

T23986
3085
hydroxacyl glutathione hydrolase; glyoxalase 2
7.26
down
0.0062

AA459420
1217
EST
7.25
down
0.0214

W94942
3658
dual specificity phosphatase 10
7.23
down
0.00137

L00972
2133
cystathionine-beta-synthase
7.19
down
0.00008

R48307
2869
EST
7.18
down
0.00007

AA442334
1069
EST
7.15
down
0.00018

AA243582
529
hemoglobin, gamma A
7.15
down
0.0021

AA437235
1060
EST
7.15
down
0.01455

N67378
2625
KIAA1053 protein
7.14
down
0

AA047151
116
EST
7.13
down
0.00007

R02572
2756
fibronectin 1
7.1
down
0.00059

glutathione S-transferase M1,glutathione S-transferase M2

M63509
2376
(muscle),glutathione S-transferase M4
7.06
down
0.03887

U49248
3373
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
7.06
down
0.00067

D90042
1767
N-acetyltransferase 2 (arylamine N-acetyltransferase)
7.06
down
0

succinate dehydrogenase complex, subunit D, integral membrane

T67231
3180
protein
7.04
down
0.03554

AA293327
716
isocitrate dehydrogenase 1 (NADP+), soluble
7.04
down
0.04377

X02750
3670
protein C (inactivator of coagulation factors Va and VIIIa)
7.04
down
0.00079

AA460661
1229
EST
7.02
down
0.00053

W28798
3491
phosphodiesterase 6A, cGMP-specific, rod, alpha
7.01
down
0.00017

AA428900
992
EST
7.01
down
0.00037

R33146
2818
EST
7
down
0.00043

AA404352
850
EST
7
down
0.00059

L40401
2211
putative protein
6.97
down
0.00079

M31627
2330
X-box binding protein 1
6.97
down
0.00052

AA608802
1470
EST
6.95
down
0.00263

AA285053
681
EST
6.95
down
0.00125

N59474
2583
EST
6.93
down
0.00337

AA258567
597
EST
6.92
down
0.00096

N91087
2716
EST
6.91
down
0.00109

N81036
2705
EST
6.89
down
0.00276

H73535
1996
EST
6.89
down
0.00202

Y00339
3844
carbonic anhydrase II
6.89
down
0

AA057678
143
EST
6.88
down
0.00078

AA609934
1493
EST
6.84
down
0.00048

AA342446
748
insulin receptor
6.83
down
0.00412

H06935
1855
electron-transferring-flavoprotein dehydrogenase
6.82
down
0.00105

H27442
1910
erythrocyte membrane protein band 7.2 (stomatin)
6.81
down
0.00083

D79276
1722
succinate-CoA ligase, GDP-forming, beta subunit
6.8
down
0.00047

AA609164
1480
cytochrome b-561
6.8
down
0.02298

W27023
3484
neuroendocrine-specific protein C like (foocen)
6.79
down
0.00805

N78902
2699
leptin receptor
6.79
down
0.0041

X95715
3832
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
6.78
down
0.00045

T95515
3260
KIAA0249 gene product
6.77
down
0.0001

H69138
1986
v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
6.76
down
0.00142

U68233
3411
nuclear receptor subfamily 1, group H, member 4
6.76
down
0.00022

AA143019
309
EST
6.75
down
0.00109

T71021
3201
EST
6.74
down
0.0017

M91432
2419
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
6.74
down
0.00008

AA205724
426
EST
6.73
down
0.00027

N59532
2584
aminomethyltransferase (glycine cleavage system protein T)
6.73
down
0.00005

T63364
3169
ficolin (collagen/fibrinogen domain-containing) 3 (Hakata antigen)
6.72
down
0.00383

AA044755
104
EST
6.7
down
0.01228

D59554
1698
EST
6.7
down
0

H66367
1977
EST
6.68
down
0.0001

X68277
3774
dual specificity phosphatase 1
6.68
down
0.0036

R50008
2886
7-dehydrocholesterol reductase
6.67
down
0.00409

D20974
1581
Vanin 1
6.66
down
0.00272

R82074
2973
syndecan 1
6.66
down
0.01336

M14058
2256
complement component 1, r subcomponent
6.66
down
0.00229

AA400979
825
calcitonin receptor-like receptor activity modifying protein 3
6.65
down
0.01051

U03056
3279
hyaluronoglucosaminidase 1
6.64
down
0

AA215919
443
F-box protein 7
6.62
down
0.00921

AA426304
962
EST
6.61
down
0.01092

AA251114
539
prostate cancer overexpressed gene 1
6.6
down
0.00039

T60407
3160
EST
6.6
down
0.00167

sphingomyelin phosphodiesterase 1, acid lysosomal (acid

AA416890
909
sphingomyelinase)
6.6
down
0.00112

AA235233
493
EST
6.59
down
0.00755

H04854
1842
interleukin 1 receptor accessory protein
6.58
down
0.00007

M16447
2270
quinoid dihydropteridine reductase
6.57
down
0.00015

C20911
1580
antithrombin III
6.56
down
0.00175

N70861
2660
EST
6.55
down
0.00001

AA010360
24
EST
6.55
down
0.00027

D00632
1591
glutathione peroxidase 3 (plasma)
6.55
down
0.00121

T69009
3191
quinoid dihydropteridine reductase
6.54
down
0.00145

M13829
2254
v-raf murine sarcoma 3611 viral oncogene homolog 1
6.52
down
0

M72885
2392
putative lymphocyte G0/G1 switch gene
6.5
down
0.03461

AA172372
370
EST
6.48
down
0.00344

D14695
1618
KIAA0025 gene product; MMS-inducible gene
6.48
down
0

AA253129
560
F-box protein FBL11
6.47
down
0.00001

T03651
3046
tubulin, beta polypeptide
6.47
down
0.00843

M94065
2424
dihydroorotate dehydrogenase
6.47
down
0.00013

M35410
2344
insulin-like growth factor binding protein 2 (36kD)
6.45
down
0.04517

Z40305
3917
EST
6.45
down
0.00001

D60856
1705
UDP-glucose dehydrogenase
6.45
down
0.01222

AA195657
419
EST
6.44
down
0.00016

H05985
1851
hypothetical protein
6.43
down
0.04887

AA281440
644
EST
6.43
down
0.01246

W26996
3483
EST
6.42
down
0.00005

U90544
3453
solute carrier family 17 (sodium phosphate), member 2
6.42
down
0.00023

glycine dehydrogenase (decarboxylating; glycine decarboxylase,

M64590
2381
glycine cleavage system protein P)
6.41
down
0.00002

H68953
1985
transferrin
6.4
down
0.00132

M20218
2288
coagulation factor XI (plasma thromboplastin antecedent)
6.4
down
0.00004

U26173
3334
nuclear factor, interleukin 3 regulated
6.4
down
0.00001

Z29481
3874
3-hydroxyanthranilate 3,4-dioxygenase
6.39
down
0.00029

AA410523
886
EST
6.37
down
0.03506

UDP-N-acteylglucosamine pyrophosphorylase 1; Sperm associated

AA447549
1101
antigen 2
6.37
down
0.02815

X85116
3811
erythrocyte membrane protein band 7.2 (stomatin)
6.37
down
0.00356

W72079
3578
EST
6.36
down
0.00641

AA621209
1516
similar to Caenorhabditis elegans protein C42C1.9
6.34
down
0.00144

W68721
3569
cleft lip and palate associated transmembrane protein 1
6.32
down
0.00063

R38185
2828
EST
6.31
down
0.0227

H41084
1924
EST
6.28
down
0.01233

AA426609
968
EST
6.28
down
0.00549

H05974
1850
EST

X83618
3810
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
6.27
down
0.02099

AA431337
1020
EST
6.26
down
0.00053

AA234817
490
EST
6.22
down
0.00099

AA398102
786
KIAA0429 gene product
6.22
down
0.00396

AA481670
1330
retinal short-chain dehydrogenase/reductase retSDR2
6.2
down
0.0078

AA608837
1472
EST
6.2
down
0.00006

N64535
2609
EST
6.19
down
0.00106

AA234527
483
nuclear receptor subfamily 3, group C, member 1
6.19
down
0.00864

M10942
2233
metallothionein 1E (functional)
6.19
down
0.00428

W42996
3514
EST
6.18
down
0.00587

Z47553
3936
flavin containing monooxygenase 5
6.17
down
0.00011

N36001
2503
EST
6.16
down
0.00222

N27670
2473
progesterone membrane binding protein
6.15
down
0.00321

N75203
2690
EST
6.15
down
0.00181

R06271
2765
EST
6.14
down
0.00063

R40946
2844
crystallin, zeta (quinone reductase)
6.14
down
0.00156

U66674
3407
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
6.13
down
0.00127

D82061
1741
Ke6 gene, mouse, human homolog of
6.1
down
0.00104

R06977
2774
glucokinase (hexokinase 4) regulatory protein
6.1
down
0.00049

W87781
3633
EST
6.1
down
0.00045

M15465
2266
pyruvate kinase, liver and RBC
6.1
down
0.00069

AA609773
1489
EST
6.09
down
0.01103

AA197311
422
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
6.07
down
0.00053

M13690
2252
complement component 1 inhibitor (angioedema, hereditary)
6.07
down
0.00045

R48540
2872
EST
6.05
down
0.00086

AA453770
1157
EST
6.04
down
0.00524

AA455097
1172
EST
6.03
down
0.00419

D82422
1745
ferroportin 1; iron regulated gene 1
6.01
down
0.02351

F13702
1826
EST
6.01
down
0.00064

M83652
2407
properdin P factor, complement
6
down
0.00002

L11708
2158
hydroxysteroid (17-beta) dehydrogenase 2
5.99
down
0.01516

glucan (1,4-alpha-), branching enzyme 1 (glycogen branching

H71861
1993
enzyme, Andersen disease, glycogen storage disease type IV)
5.97
down
0.00007

X97324
3836
adipose differentiation-related protein; adipophilin
5.97
down
0.04638

aldo-keto reductase family 7, member A2 (aflatoxin aldehyde

AA157799
348
reductase)
5.96
down
0

M35590
2345
small inducible cytokine A4
5.96
down
0.00604

H02855
1832
EST
5.96
down
0.00458

C16420
1576
EST
5.95
down
0.00119

X07767
3691
protein kinase, cAMP-dependent, catalytic, alpha
5.94
down
0.00028

AA045870
108
EST
5.93
down
0.00017

Z80345
3948
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain
5.93
down
0.0024

N93764
2736
EST
5.92
down
0.0109

AA031543
68
translocation protein 1
5.92
down
0.00405

AA620667
1506
protein tyrosine phosphatase type IVA, member 1
5.92
down
0.00206

tissue factor pathway inhibitor (lipoprotein-associated coagulation

M59499
2363
inhibitor)
5.92
down
0.0005

X91148
3818
microsomal triglyceride transfer protein (large polypeptide, 88kD)
5.91
down
0.00045

R09053
2782
EST
5.9
down
0.0002

Z39476
3905
EST
5.9
down
0.00687

AA233347
470
zinc finger protein 216
5.9
down
0.0041

M13232
2251
coagulation factor VII (serum prothrombin conversion accelerator)
5.9
down
0.00014

T69384
3197
period (Drosophila) homolog 1
5.88
down
0.01219

D51279
1679
ovarian granulosa cell protein (13kD)
5.88
down
0.01271

M64554
2380
coagulation factor XIII, B polypeptide
5.87
down
0.00011

C02099
1560
CGI-131 protein
5.85
down
0.02377

Y08409
3851
thyroid hormone responsive SPOT14 (rat) homolog
5.84
down
0.00455

H99727
2080
adipose differentiation-related protein; adipophilin
5.83
down
0.04346

L13278
2163
crystallin, zeta (quinone reductase)
5.83
down
0.0034

S77356
3033
EST
5.83
down
0.00122

M16474
2271
butyrylcholinesterase
5.82
down
0.00113

U32576
3346
apolipoprotein C-IV
5.81
down
0.04343

D37931
1650
ribonuclease, RNase A family, 4
5.81
down
0.00836

AA446587
1091
EST
5.8
down
0.00012

R93908
2993
EST
5.8
down
0.02699

AA086201
185
EST
5.8
down
0.00012

AA164586
359
estrogen receptor 1
5.8
down
0.00182

AF007216
1550
solute carrier family 4, sodium bicarbonate cotransporter, member 4
5.79
down
0.00005

AA479498
1314
EST
5.78
down
0.01489

AA424813
948
EST
5.77
down
0.00503

H03348
1833
claudin 1
5.77
down
0.0001

R62173
2923
UDP-glucose dehydrogenase
5.76
down
0.0006

Z39976
3912
EST
5.76
down
0.00012

AA219039
446
EST
5.76
down
0.00053

AA608751
1469
EST
5.76
down
0.01404

T95064
3259
EST
5.75
down
0.00604

H09364
1867
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
5.74
down
0.03125

T90841
3250
EST
5.74
down
0.01876

T03441
3043
cytochrome b-561
5.74
down
0.02781

AA424307
944
EST
5.73
down
0.0074

AA398386
793
EST
5.71
down
0.00007

R43910
2851
EST
5.71
down
0

U12778
3300
acyl-Coenzyme A dehydrogenase, short/branched chain
5.68
down
0.00116

AA255903
573
CD39-like 4
5.67
down
0.01687

quinolinate phosphoribosyltransferase (nicotinate-nucleotide

AA252289
552
pyrophosphorylase (carboxylating))
5.66
down
0.01389

AA262766
609
EST
5.66
down
0.03832

T64887
3172
protein phosphatase 5, catalytic subunit
5.66
down
0.00349

D11802
1597
angiotensinogen
5.65
down
0.00009

D45714
1664
EST
5.64
down
0.00384

U70732
3414
glutamic-pyruvate transaminase (alanine aminotransferase)
5.64
down
0.00146

H88675
2022
EST
5.63
down
0.00554

AA442342
1070
EST
5.62
down
0.00052

T79863
3225
EST
5.62
down
0.00074

AA454733
1169
EST
5.61
down
0.01182

W72972
3584
EST
5.61
down
0.00939

N95495
2741
EST
5.61
down
0.00308

J03764
2097
plasminogen activator inhibitor, type I
5.6
down
0.02196

glucan (1,4-alpha-), branching enzyme 1 (glycogen branching

L07956
2148
enzyme, Andersen disease, glycogen storage disease type IV)
5.6
down
0.00029

AA090439
192
ribosomal protein S6
5.58
down
0.00501

AA419507
924
EST
5.58
down
0.00578

AA236982
520
sterol carrier protein 2
5.56
down
0.01542

glutamate-cysteine ligase (gamma-glutamylcysteine synthetase),

L35546
2203
regulatory (30.8kD)
5.56
down
0.0005

M16967
2275
coagulation factor V (proaccelerin, labile factor)
5.56
down
0.00047

AB002328
1536
calcineurin binding protein 1
5.55
down
0.00016

AA450281
1134
EST
5.55
down
0.00004

W47175
3531
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2
5.54
down
0.00914

N52845
2553
EST
5.53
down
0.00088

AA425782
956
KIAA0874 protein
5.52
down
0.03433

R10684
2787
EST
5.51
down
0.00741

AA436926
1059
EST
5.5
down
0.00984

AA452598
1148
genethonin 1
5.49
down
0.00163

D11756
1596
EST
5.49
down
0.01272

AA223335
449
propionyl Coenzyme A carboxylase, beta polypeptide
5.49
down
0.02761

D87436
1761
KIAA0249 gene product
5.49
down
0.00333

J04080
2105
complement component 1, s subcomponent
5.48
down
0.0239

X65962
3766
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase)
5.47
down
0.00014

AA443822
1082
EST
5.46
down
0.02538

AA485089
1341
EST
5.46
down
0.00044

AA032048
72
EST
5.45
down
0.00383

AA400471
816
EST
5.45
down
0.0056

AA490159
1374
glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
5.44
down
0

M12174
2242
ras homolog gene family, member B
5.44
down
0.0088

U11313
3296
sterol carrier protein 2
5.44
down
0.00187

N65959
2611
EST
5.43
down
0.00044

AA482594
1337
EST
5.42
down
0.00387

AA455865
1180
phosphatidylinositol glycan, class B
5.41
down
0.00004

N23761
2456
DKFZP586G011 protein
5.41
down
0.00448

U49352
3374
2,4-dienoyl CoA reductase 1, mitochondrial
5.41
down
0.02371

R63545
2926
EST
5.4
down
0.00202

AA258308
590
EST
5.4
down
0.00023

R34362
2821
KIAA0327 gene product
5.4
down
0.04615

AA621192
1515
EST
5.39
down
0.0016

T69020
3192
EST
5.39
down
0.00383

AA598679
1434
EST
5.37
down
0.00467

R43365
2849
EST
5.37
down
0.00103

AA455987
1183
EST
5.36
down
0.00029

C01257
1554
EST
5.35
down
0.00608

D31716
1647
basic transcription element binding protein 1
5.35
down
0.00086

L05779
2140
epoxide hydrolase 2, cytoplasmic
5.35
down
0.00006

UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine

AA490775
1380
kinase
5.34
down
0.00118

R15825
2791
KIAA0946 protein; Huntingtin interacting protein H
5.33
down
0.00391

AA342771
749
EST
5.33
down
0.00331

F10466
1820
EST
5.32
down
0.02494

S72370
3029
pyruvate carboxylase
5.31
down
0.00075

N27834
2474
alpha2,3-sialyltransferase
5.31
down
0.00039

D31117
1640
ribosome binding protein 1 (dog 180kD homolog)
5.3
down
0.02749

AA032005
71
EST
5.3
down
0.01202

N48315
2526
adaptor-related protein complex 2, mu 1 subunit
5.3
down
0.0149

T08879
3048
cathepsin F
5.29
down
0.0008

X02160
3668
insulin receptor
5.29
down
0.0001

Z24459
3866
mature T-cell proliferation 1
5.29
down
0.00001

AA236230
508
EST
5.28
down
0.01517

AA258353
593
EST
5.28
down
0.00193

N64017
2605
EST
5.27
down
0.00022

X90999
3817
hydroxyacyl glutathione hydrolase; glyoxalase 2
5.27
down
0.00047

AA347717
754
EST
5.25
down
0.00207

U19523
3319
GTP cyclohydrolase 1 (dopa-responsive dystonia)
5.25
down
0.00029

cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide

J04449
2110
3
5.25
down
0.01583

AA428150
985
EST
5.24
down
0.00167

N20113
2438
EST
5.24
down
0.01346

N70057
2653
DNA segment on chromosome 6 (unique) 49 expressed sequence
5.24
down
0.01178

N62652
2592
EST
5.23
down
0.03006

AA461057
1234
nuclear localization signal deleted in velocardiofacial syndrome
5.22
down
0.00051

guanine nucleotide binding protein (G protein), alpha inhibiting

X04828
3680
activity polypeptide 2
5.22
down
0.01278

AA044842
105
Autosomal Highly Conserved Protein
5.21
down
0.0009

AA005358
14
EST
5.2
down
0.00318

N25082
2462
amplified in osteosarcoma
5.19
down
0.00895

Z39059
3896
EST
5.19
down
0.0014

J04056
2104
carbonyl reductase 1
5.19
down
0.00001

U00115
3271
B-cell CLL/lymphoma 6 (zinc finger protein 51)
5.18
down
0.00045

AA046674
112
EST
5.17
down
0.02561

C20810
1579
EST
5.17
down
0.00614

5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate

L38928
2209
cyclo-ligase)
5.17
down
0.00726

L76687
2227
growth factor receptor-bound protein 14
5.16
down
0.00199

AA456055
1185
EST
5.16
down
0.00158

H14372
1883
ATP-binding cassette, sub-family A (ABC1), member 5
5.16
down
0.00012

H88359
2020
nuclear factor (erytroid-derived 2)-like 2
5.16
down
0.01253

U60205
3400
sterol-C4-methyl oxidase-like
5.16
down
0.00061

N79778
2701
extracellular matrix protein 2, female organ and adipocyte specific
5.15
down
0.00286

H54285
1947
EST
5.14
down
0.00426

M99439
2437
transducin-like enhancer of split 4, homolog of Drosophila E(sp1)
5.14
down
0.00001

AA094999
204
zinc finger protein 216
5.12
down
0.0257

UDP-N-acteylglucosamine pyrophosphorylase 1; Sperm associated

AA114949
228
antigen 2
5.12
down
0.01028

AA430666
1016
EST
5.12
down
0.00377

AA149253
323
EST
5.12
down
0.00863

R48732
2875
EST
5.12
down
0.00837

L36033
2204
stromal cell-derived factor 1
5.1
down
0.00603

F10875
1824
EST
5.09
down
0.00004

H98083
2067
EST
5.09
down
0.00025

AA258350
592
EST
5.08
down
0.00035

AA191014
396
EST
5.07
down
0.01455

AA478441
1302
cathepsin F
5.07
down
0.00752

AA599472
1451
succinate-CoA ligase, GDP-forming, beta subunit
5.07
down
0.00447

D79687
1723
KIAA1053 protein
5.06
down
0.00047

glutamate-cysteine ligase (gamma-glutamylcysteine synthetase),

H93053
2034
catalytic (72.8kD)
5.06
down
0.01029

W45560
3522
EST
5.06
down
0.00996

AA443756
1080
EST
5.05
down
0.00341

D51199
1677
EST
5.05
down
0.00192

AA620343
1500
EST
5.04
down
0.00407

T15482
3059
EST
5.04
down
0.00233

H46001
1931
EST
5.03
down
0.00563

R51831
2890
EST
5.03
down
0.00761

W57821
3545
EST
5.03
down
0.00277

W63728
3562
EST
5.03
down
0.00311

AA609574
1485
EST
5.03
down
0

N62523
2591
hepatic leukemia factor
5.02
down
0.00087

AA449306
1122
EST
5.01
down
0.0006

AA279533
627
EST
5.01
down
0.04448

N67105
2623
EST
5.01
down
0.00176

S74728
3032
antiquitin 1
5.01
down
0.00008

AA070091
153
EST
5
down
0

AA292086
705
EST
5
down
0.00161

R82837
2975
KIAA0970 protein
5
down
0.00181

AA486567
1350
EST
5
down
0.00002

H78628
2003
EST
4.98
down
0.00729

AA416936
910
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
4.98
down
0.00632

AA400934
824
EST
4.98
down
0.02013

D31381
1644
dynein, axonemal, light polypeptide 4
4.97
down
0.01806

AA210850
431
EST
4.97
down
0.00735

L41067
2213
nuclear factor of activated T-cells, cytoplasmic 3
4.96
down
0.00473

AA450114
1131
EST
4.96
down
0.01238

X92744
3824
defensin, beta 1
4.96
down
0.01804

cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -

X07619
3689
metabolising), polypeptide 7a (pseudogene)
4.96
down
0.00004

AA406125
868
EST
4.95
down
0.01027

M95767
2431
chitobiase, di-N-acetyl-
4.94
down
0.00004

H03945
1835
EST
4.94
down
0.02603

X96752
3834
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
4.94
down
0.00359

AA282089
653
EST
4.93
down
0.00108

AA463194
1244
KIAA1037 protein
4.92
down
0.01866

W81053
3607
EST
4.91
down
0.00164

R06764
2771
apolipoprotein B (including Ag(x) antigen)
4.91
down
0.00167

X58528
3745
ATP-binding cassette, sub-family D (ALD), member 3
4.91
down
0.00728

AA425309
953
nuclear factor I/B
4.9
down
0.00466

AA451836
1137
EST
4.9
down
0.01412

H91456
2030
nuclear receptor subfamily 1, group H, member 4
4.9
down
0.00255

solute carrier family 25 (mitochondrial carrier; citrate transporter),

W86850
3628
member 1
4.9
down
0.03105

S69232
3026
electron-transferring-flavoprotein dehydrogenase
4.9
down
0.00017

X62822
3755
sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)
4.89
down
0.00274

W60002
3552
plastin 3 (T isoform)
4.88
down
0.01694

U51333
3382
hexokinase 3 (white cell)
4.88
down
0.00055

R56094
2904
EST
4.87
down
0.00214

AA314457
733
synaptonemal complex protein 3
4.86
down
0.0013

N90820
2714
DKFZP566B1346 protein
4.86
down
0.03008

T98199
3266
EST
4.86
down
0.00431

D61991
1706
EST
4.84
down
0.00005

AA446342
1088
seven in absentia (Drosophila) homolog 1
4.84
down
0.00015

U53003
3387
ES1 (zebrafish) protein, human homolog of
4.84
down
0.00077

D87466
1763
KIAA0276 protein
4.83
down
0.0007

D45556
1663
EST
4.83
down
0.01044

AA046747
114
EST
4.82
down
0.00022

AA464188
1256
EST
4.82
down
0.03208

N26184
2466
MYLE protein
4.82
down
0.00056

AA056482
141
EST
4.82
down
0.00199

KIAA0382 protein; leukemia-associated rho guanine nucleotide

AA370359
767
exchange factor (GEF)
4.82
down
0.01077

N54311
2563
EST
4.82
down
0.00183

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A

L07077
2145
dehydrogenase
4.82
down
0.00403

U68494
3412
EST
4.82
down
0.00881

potassium voltage-gated channel, shaker-related subfamily, member

M55513
2354
5
4.81
down
0.02141

W74158
3593
EST
4.81
down
0.00233

acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-

D16294
1619
Coenzyme A thiolase)
4.81
down
0.03921

X13227
3695
D-amino-acid oxidase
4.81
down
0.0002

AA417373
917
EST
4.8
down
0.01342

F09350
1801
EST
4.79
down
0.00088

AA233837
474
EST
4.79
down
0.0034

N29353
2476
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
4.78
down
0.00019

AA291749
703
estrogen receptor 1
4.78
down
0.00059

AA461303
1238
DKFZP586D1519 protein
4.77
down
0.0438

AA490620
1378
EST
4.77
down
0.00201

H94648
2044
EST
4.77
down
0.00266

AA228119
462
pre-B-cell colony-enhancing factor
4.77
down
0.00031

AA449327
1123
EST
4.77
down
0.01248

X00351
3665
actin, beta
4.76
down
0.0003

L05144
2139
phosphoenolpyruvate carboxykinase 1 (soluble)
4.76
down
0.02289

N49214
2535
EST
4.74
down
0.00064

N59089
2580
EST
4.74
down
0.00055

M35590
2345
small inducible cytokine A4
4.74
down
0.01225

T41047
3119
EST
4.74
down
0.00015

M55671
2355
protein Z, vitamin K-dependent plasma glycoprotein
4.74
down
0.00078

AA400834
820
EST
4.73
down
0.01523

X57025
3739
insulin-like growth factor 1 (somatomedin C)
4.72
down
0.00087

AA432168
1031
S-adenosylhomocysteine hydrolase-like 1
4.71
down
0.01377

AA435753
1045
EST
4.71
down
0.00078

AA227452
455
EST
4.7
down
0.02345

T70087
3199
EST
4.7
down
0.00173

AA477919
1293
EST
4.69
down
0.00141

AA194075
406
nuclear receptor coactivator 4
4.69
down
0.00862

AA424672
946
dermatopontin
4.69
down
0.00843

U03105
3280
proline-rich protein with nuclear targeting signal
4.69
down
0.00017

X78992
3799
butyrate response factor 2 (EGF-response factor 2)
4.69
down
0.01995

W45051
3518
EST
4.68
down
0.00433

W80609
3603
EST
4.68
down
0.01729

cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase)

N53549
2558
polypeptide 2
4.68
down
0.00818

F09578
1804
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
4.66
down
0.04463

H98071
2066
EST
4.66
down
0.03722

N59283
2582
EST
4.65
down
0.02343

N72259
2669
cornichon-like
4.65
down
0.0054

cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase,

X59812
3747
cerebrotendinous xanthomatosis), polypeptide 1
4.65
down
0.036

X78706
3798
carnitine acetyltransferase
4.65
down
0.00442

M31169
2325
propionyl Coenzyme A carboxylase, beta polypeptide
4.65
down
0.00467

R22905
2800
EST
4.64
down
0.0043

D80050
1726
EST
4.64
down
0.01001

AA258813
600
EST
4.63
down
0.02395

AA256666
583
EST
4.63
down
0.0018

AA004905
11
KIAA0937 protein
4.63
down
0.00082

M35590
2345
small inducible cytokine A4
4.62
down
0.01268

AA069768
151
hevin
4.62
down
0.00202

AA419622
926
EST
4.62
down
0.00386

M27492
2312
interleukin 1 receptor, type I
4.62
down
0.0082

AA090434
191
diaphanous (Drosophila, homolog) 1
4.61
down
0.01704

AA233763
472
EST
4.61
down
0.00004

AA151210
333
EST
4.61
down
0.00008

androgen receptor (dihydrotestosterone receptor; testicular

M23263
2300
feminization; spinal and bulbar muscular atrophy; Kennedy disease)
4.6
down
0.00005

H40149
1921
KIAA0937 protein
4.59
down
0.00112

U19495
3318
stromal cell-derived factor 1
4.59
down
0.00011

AA436690
1057
EST
4.58
down
0.00948

N29319
2475
EST
4.58
down
0.00011

R64144
2931
cAMP responsive element binding protein-like 2
4.58
down
0.00495

T73420
3210
short-chain dehydrogenase/reductase 1
4.58
down
0.00656

D87449
1762
KIAA0260 protein
4.58
down
0.00026

phosphodiesterase I/nucleotide pyrophosphatase 1 (homologous to

D12485
1600
mouse Ly-41 antigen)
4.57
down
0.00008

AA211388
433
EST
4.56
down
0.02703

AA133215
277
calcitonin receptor-like receptor activity modifying protein 1
4.55
down
0.02092

AA425836
957
EST
4.55
down
0.00035

N45307
2517
EST
4.55
down
0.00006

M12625
2245
lecithin-cholesterol acyltransferase
4.55
down
0.01584

AA348284
755
EST
4.54
down
0.00759

H10661
1871
EST
4.54
down
0.00276

AA485413
1344
EST
4.54
down
0.00137

C21238
1584
EST
4.54
down
0.02074

S72370
3029
pyruvate carboxylase
4.54
down
0.0001

AA521290
1421
EST
4.53
down
0.0148

R92737
2987
EST
4.53
down
0.04447

AA250775
537
EST
4.52
down
0.01752

AA052980
122
EST
4.52
down
0.023

AA253459
566
EST
4.51
down
0.00419

N47942
2522
progesterone membrane binding protein
4.51
down
0.00168

T25506
3089
EST
4.51
down
0.00529

R59325
2913
EST
4.48
down
0.00117

U77396
3425
LPS-induced TNF-alpha factor
4.47
down
0.00108

AA280413
638
spleen focus forming virus (SFFV) proviral integration oncogene spi1
4.46
down
0.02062

AA406231
873
KIAA0381 protein
4.46
down
0.04049

AA452454
1144
EST
4.45
down
0.00179

AA431462
1022
EST
4.45
down
0.00956

U79303
3435
protein predicted by clone 23882
4.45
down
0

AA621796
1531
kinesin family member 3B
4.44
down
0.00032

L76571
2226
nuclear receptor subfamily 0, group B, member 2
4.44
down
0.00312

D57823
1690
Sec23 (S. cerevisiae) homolog A
4.43
down
0

AA398257
791
7-dehydrocholesterol reductase
4.43
down
0.04169

AA214542
438
EST
4.43
down
0.00601

Z48199
3939
syndecan 1
4.43
down
0.00408

H88033
2019
KIAA0733 protein
4.42
down
0.02032

W69675
3572
EST
4.42
down
0.00019

C01409
1556
EST
4.41
down
0.01725

R94662
2994
heme-binding protein
4.41
down
0.02301

N70305
2654
EST
4.41
down
0.00078

AA262033
606
EST
4.41
down
0.00054

H57816
1957
EST
4.41
down
0.00206

N48787
2530
protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin
4.4
down
0.00292

R44025
2853
EST
4.4
down
0.01325

Z39622
3907
EST
4.4
down
0.00001

N73468
2673
protein S (alpha)
4.4
down
0.00853

R36228
2823
EST
4.39
down
0.00033

T71978
3204
EST
4.39
down
0.0017

AA437265
1061
EST
4.39
down
0.00826

N93155
2728
calmodulin 1 (phosphorylase kinase, delta)
4.39
down
0.0002

Z38161
3881
EST
4.38
down
0.0011

H98910
2071
EST
4.38
down
0.00548

N23730
2455
v-fos FBJ murine osteosarcoma viral oncogene homolog
4.38
down
0.04395

T69164
3194
EST
4.38
down
0.00548

cytochrome P450, subfamily I (aromatic compound-inducible),

M31667
2331
polypeptide 2
4.38
down
0.00078

AA193297
404
EST
4.37
down
0.04676

AA427783
979
EST
4.37
down
0.0004

N22434
2450
EST
4.37
down
0.01725

W37382
3501
EST
4.37
down
0.00677

AA282971
665
EST
4.37
down
0.03822

D11881
1599
KIAA0962 protein
4.37
down
0.01627

F09979
1809
EST
4.36
down
0.02555

W92771
3652
glycine cleavage system protein H (aminomethyl carrier)
4.36
down
0.0064

AA437295
1062
ribosomal protein L7a
4.35
down
0.00347

AA452559
1147
EST
4.35
down
0.00804

W90583
3645
EST
4.35
down
0.00318

T97234
3264
EST
4.34
down
0.00263

U57721
3394
kynureninase (L-kynurenine hydrolase)
4.34
down
0.0197

T85532
3235
EST
4.33
down
0.00591

AA421244
932
SH3-domain binding protein 5 (BTK-associated)
4.32
down
0.007

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue

N25969
2465
specific extinguisher 1)
4.32
down
0.00304

W73818
3590
EST
4.32
down
0.00385

S90469
3039
P450 (cytochrome) oxidoreductase
4.32
down
0.0182

AA258613
598
EST
4.31
down
0.0344

AA001603
3
EST
4.31
down
0.00883

AA258323
591
EST
4.31
down
0.00046

D60769
1703
KIAA0096 protein
4.31
down
0.00142

aldehyde dehydrogenase 9 (gamma-aminobutyraldehyde

U34252
3349
dehydrogenase, E3 isozyme)
4.31
down
0.00613

AA431480
1023
EST
4.3
down
0.00876

N39163
2508
metallothionein 1L
4.3
down
0.03917

M35878
2346
insulin-like growth factor binding protein 3
4.3
down
0.0027

Z11559
3859
iron-responsive element binding protein 1
4.3
down
0.00066

AA454086
1161
UDP-glucose dehydrogenase
4.29
down
0.00981

X59834
3748
glutamate-ammonia ligase (glutamine synthase)
4.29
down
0.00255

W58540
3550
KIAA1131 protein
4.28
down
0.0184

T81315
3226
EST
4.28
down
0.00187

AA398445
796
EST
4.28
down
0.01764

AA521306
1423
EST
4.27
down
0.00567

R99909
3016
EST
4.27
down
0.00045

solute carrier family 22 (extraneuronal monoamine transporter),

AA460012
1224
member 3
4.27
down
0.04975

U46499
3364
microsomal glutathione S-transferase 1
4.27
down
0.00244

M83216
2406
caldesmon 1
4.27
down
0.00037

AA136079
297
EST
4.26
down
0.0057

L40401
2211
putative protein
4.26
down
0.00194

D31887
1649
KIAA0062 protein
4.26
down
0.00101

M80482
2402
paired basic amino acid cleaving system 4
4.26
down
0.00041

N73461
2672
EST
4.25
down
0.00162

M68895

alcohol dehydrogenase 6 (class V)
4.25
down
0.00354

U48296
3368
protein tyrosine phosphatase type IVA, member 1
4.25
down
0.02037

AA426330
963
N-acylsphingosine amidohydrolase (acid ceramidase)-like
4.24
down
0.00668

Y10032
3855
serum/glucocorticoid regulated kinase
4.24
down
0.00148

AA456147
1188
general transcription factor IIIA
4.23
down
0.00088

AA456589
1194
EST
4.23
down
0.00102

AA243495
528
lectin, mannose-binding, 1
4.23
down
0.00179

AA491000
1385
EST
4.23
down
0.02305

AA133296
278
EST
4.23
down
0.00041

AA299632
728
EST
4.23
down
0.00371

T10322
3052
dihydropyrimidinase-like 2
4.23
down
0.01527

glutathione S-transferase M1,glutathione S-transferase M2

M96233
2432
(muscle),glutathione S-transferase M4
4.23
down
0.04227

N77606
2696
EST
4.22
down
0.00119

Y10659
3856
interleukin 13 receptor, alpha 1
4.22
down
0.00061

AA150891
331
EST
4.22
down
0.01692

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1

AA203222
424
(chondrocyte-derived)
4.21
down
0.00745

PDZ domain containing guanine nucleotide exchange factor(GEF)1;

AB002311
1535
RA(Ras/Rap1A-associating)-GEF
4.21
down
0.00476

AA428607
990
ribosomal protein S5 pseudogene 1
4.21
down
0.04305

AA417375
918
EST
4.21
down
0.00231

AA504492
1414
tubulin, alpha, ubiquitous
4.21
down
0.00752

N52985
2554
nidogen (enactin)
4.21
down
0.01385

W81268
3609
protein kinase, interferon-inducible double stranded RNA dependent
4.2
down
0.00007

H08054
1857
EST
4.2
down
0.0009

AA193223
403
EST
4.2
down
0.02416

T48980
3133
calmodulin 1 (phosphorylase kinase, delta)
4.2
down
0.0046

X72012
3786
endoglin (Osler-Rendu-Weber syndrome 1)
4.2
down
0.005

M95585
2429
hepatic leukemia factor
4.2
down
0.00212

AA402006
834
EST
4.19
down
0.00094

AA101632
217
EST
4.19
down
0.00023

F10874
1823
EST
4.19
down
0.00025

L00352
2131
low density lipoprotein receptor (familial hypercholesterolemia)
4.19
down
0.00352

S67325
3023
propionyl Coenzyme A carboxylase, beta polypeptide
4.19
down
0.00151

Z39406
3902
nuclear receptor co-repressor 1
4.18
down
0.00439

D00723
1592
glycine cleavage system protein H (aminomethyl carrier)
4.18
down
0.00543

F13782
1827
LIM binding domain 2
4.17
down
0.00109

H90417
2028
EST
4.17
down
0.015

W38407
3503
EST
4.17
down
0.00392

AA135558
293
peptidase D
4.17
down
0.0068

D31289
1642
EST
4.16
down
0.02166

W88568
3635
glycogenin 2
4.16
down
0.00111

AA036662
83
EST
4.16
down
0.00235

AA404500
852
EST
4.16
down
0.01375

R05518
2761
EST
4.15
down
0.0125

phosphorylase, glycogen; liver (Hers disease, glycogen storage

H91680
2032
disease type VI)
4.15
down
0.00746

D87075
1760
solute carrier family 23 (nucleobase transporters), member 1
4.15
down
0.00067

U90545
3454
solute carrier family 17 (sodium phosphate), member 3
4.14
down
0.00005

H11274
1874
EST
4.13
down
0.01478

AA040087
92
EST
4.13
down
0.00123

R34133
2820
EST
4.13
down
0.00008

AA280130
636
EST
4.12
down
0.00114

T15674
3060
EST
4.12
down
0.02111

M62403
2373
insulin-like growth factor-binding protein 4
4.12
down
0.00226

C01286
1555
integral membrane protein 2B
4.11
down
0.00292

D62103
1707
EST
4.11
down
0.0263

H69565
1987
EST
4.11
down
0.00002

AA190816
395
EST
4.1
down
0.00037

N66422
2615
EST
4.1
down
0.00237

AA417078
916
EST
4.1
down
0.00414

N21079
2440
nucleolar cysteine-rich protein
4.1
down
0.00028

R87373
2977
EST
4.09
down
0.02253

X58022
3744
corticotropin releasing hormone-binding protein
4.09
down
0.00076

AA065173
148
EST
4.08
down
0.00377

AA219653
448
EST
4.08
down
0.00607

M96843
2434
EST
4.08
down
0.02912

AA400251
811
EST
4.07
down
0.00032

N91273
2717
EST
4.07
down
0.02965

AA133439
279
EST
4.07
down
0.00022

AA463729
1250
EST
4.07
down
0.00676

R70790
2947
EST
4.07
down
0.02354

AA279550
628
Kruppel-like factor
4.06
down
0.00957

N36250
2505
cellular repressor of E1A-stimulated genes
4.06
down
0.00776

N48674
2529
EST
4.06
down
0.00028

AA255624
571
EST
4.06
down
0.00069

L09717
2153
lysosomal-associated membrane protein 2
4.06
down
0.00034

HG2743-HT2845

caldesmon 1
4.06
down
0.00453

AA188921
393
similar to Caenorhabditis elegans protein C42C1.9
4.05
down
0.004

AA191647
399
ceruloplasmin (ferroxidase)
4.05
down
0.00029

AA084408
179
EST
4.05
down
0.00864

cytochrome P450, subfamily 1 (aromatic compound-inducible),

AA418907
922
polypeptide 1
4.05
down
0.04276

AA608807
1471
inhibin, beta B (activin AB beta polypeptide)
4.05
down
0.00568

AA478416
1300
EST
4.04
down
0.00078

M63967
2378
aldehyde dehydrogenase 5
4.04
down
0.00058

T68083
3184
short-chain dehydrogenase/reductase 1
4.03
down
0.01593

AA446666
1094
EST
4.03
down
0.02369

AA465240
1270
EST
4.03
down
0.0046

W46391
3524
alpha integrin binding protein 63
4.03
down
0.01363

W52821
3541
leucine aminopeptidase
4.02
down
0.03787

AA135958
296
EST
4.02
down
0.00012

AA609774
1490
EST
4.02
down
0.00424

H96614
2054
EST
4.02
down
0.01565

R32036
2815
interleukin 1 receptor-like 1
4.02
down
0.00051

R61740
2922
EST
4.02
down
0.00321

L17128
2167
gamma-glutamyl carboxylase
4.02
down
0.00096

AA348485
757
KIAA0438 gene product
4.01
down
0.04563

AA151676
337
peptidyl arginine deiminase, type II
4.01
down
0.00911

F04944
1795
acyl-Coenzyme A oxidase
4.01
down
0.00242

D63160
1709
ficolin (collagen/fibrinogen domain-containing lectin) 2 (hucolin)
4.01
down
0.00391

J03242
2092
insulin-like growth factor 2 (somatomedin A)
4.01
down
0.00042

AA255546
569
EST
4
down
0.00301

AA411764
891
similar to APOBEC1
4
down
0.01491

AA479488
1313
S-adenosylhomocysteine hydrolase-like 1
4
down
0.0269

R10138
2783
EST
4
down
0.00032

T16478
3069
EST
4
down
0.01041

H71169
1992
putative protein similar to nessy (Drosophila)
4
down
0.00709

X76648
3793
glutaredoxin (thioltransferase)
4
down
0.00211

AA428567
989
EST
3.99
down
0.00788

N22404
2449
EST
3.99
down
0.01152

T90037
3245
EST
3.99
down
0.0016

AA452860
1151
EST
3.99
down
0.00831

H83442
2013
catechol-O-methyltransferase
3.99
down
0.00594

W85888
3619
EST
3.99
down
0.00697

X05409
3681
aldehyde dehydrogenase 2, mitochondrial
3.99
down
0.01029

R00296
2749
EST
3.98
down
0.04632

T69728
3198
heat shock 90kD protein 1, beta
3.98
down
0.00786

AA495820
1393
EST
3.98
down
0.00218

AA400030
806
EST
3.98
down
0.00089

N66130
2613
progesterone membrane binding protein
3.98
down
0.0106

HG2379-HT3997

serine hydroxymethyltransferase 1 (soluble)
3.98
down
0.00306

R42241
2845
EST
3.97
down
0.00129

AA449448
1125
EST
3.97
down
0.00103

N53757
2559
EST
3.97
down
0.00255

AA401376
829
EST
3.97
down
0.00797

M29971
2320
O-6-methylguanine-DNA methyltransferase
3.97
down
0.00424

AA281770
649
seven in absentia (Drosophila) homolog 1
3.96
down
0.00094

AA454184
1165
EST
3.96
down
0.04605

AA255878
572
KIAA0767 protein
3.96
down
0.00592

R52800
2894
EST
3.96
down
0.00749

M68840
2388
monoamine oxidase A
3.96
down
0.01396

U16660
3312
enoyl Coenzyme A hydratase 1, peroxisomal
3.96
down
0.00002

AA281677
648
DKFZP564M2423 protein
3.95
down
0.03606

AA495758
1391
EST
3.94
down
0.00772

W36290
3500
Kreisler (mouse) maf-related leucine zipper homolog
3.94
down
0.02718

AA609011
1476
EST
3.94
down
0.0313

T79758
3223
EST
3.94
down
0.00581

W88985
3637
KIAA0903 protein
3.94
down
0.00295

AA157112
345
EST
3.94
down
0.02571

AA398422
794
EST
3.94
down
0.00388

U78190
3430
GTP cyclohydrolase 1 feedback regulatory protein
3.94
down
0.034

R98774
3013
EST
3.93
down
0.00001

AA435824
1048
EST
3.93
down
0.02764

AA609996
1495
EST
3.93
down
0.00988

M55150
2352
fumarylacetoacetate
3.93
down
0.00213

U50527
3377
EST
3.93
down
0.00123

H11746
1877
EST
3.92
down
0.00012

L09708
2152
complement component 2
3.92
down
0.00693

U20938
3323
dihydropyrimidine dehydrogenase
3.92
down
0.00053

W63785
3564
EST
3.91
down
0.04089

R31917
2814
EST
3.91
down
0.00071

R96417
2997
EST
3.9
down
0.00019

F02245
1776
monoamine oxidase A
3.9
down
0.02943

F02345
1779
EST
3.9
down
0.0033

AA252365
554
EST
3.9
down
0.01796

C14963
1572
nicotinamide nucleotide transhydrogenase
3.9
down
0.0044

T24055
3086
ribosomal protein L26
3.9
down
0.00046

AA599234
1447
murine leukemia viral (bmi-1) oncogene homolog
3.9
down
0.0068

AA253043
559
DKFZP586I1419 protein,
3.89
down
0.00145

Z40192
3915
EST
3.89
down
0.00223

AA342301
746
EST
3.89
down
0.00038

AA608729
1468
EST
3.89
down
0.01757

AA234561
485
EST
3.88
down
0.02058

H65650
1976
EST
3.88
down
0.0083

N68730
2636
EST
3.88
down
0.00091

T90492
3247
EST
3.88
down
0.00454

M10943
2234
metallothionein 1F (functional)
3.88
down
0

T68510
3186
EST
3.87
down
0.00617

AA448282
1115
EST
3.87
down
0.00217

H18997
1893
F-box protein 21
3.87
down
0.00611

AA251837
547
EST
3.87
down
0.00782

AA342337
747
EST
3.87
down
0.0069

L22548
2178
collagen, type XVIII, alpha 1
3.87
down
0.0299

J03805
2098
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
3.87
down
0.0116

H87765
2017
KIAA0626 gene product
3.86
down
0.00131

W94427
3656
EST
3.86
down
0.02649

H97868
2064
EST
3.86
down
0.00362

H97986
2065
EST
3.86
down
0.01534

H18950
1892
EST
3.85
down
0.00162

T10108
3049
EST
3.85
down
0.01155

AA447977
1111
EST
3.84
down
0.00045

T10264
3050
EST
3.84
down
0.00874

Z11737
3860
flavin containing monooxygenase 4
3.84
down
0.00043

U49785
3375
D-dopachrome tautomerase
3.84
down
0.00044

M30185
2321
cholesteryl ester transfer protein, plasma
3.83
down
0.0013

W85765
3615
EST
3.83
down
0.00379

D80218
1728
brain acid-soluble protein 1
3.83
down
0.0137

H68097
1982
EST
3.83
down
0.00797

N49104
2533
nuclear receptor interacting protein 1
3.83
down
0.00144

D16350
1620
SA (rat hypertension-associated) homolog
3.83
down
0.00117

Z31690
3878
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)
3.83
down
0.00103

AA056170
137
EST
3.82
down
0.0083

AA093923
200
EST
3.82
down
0.03924

U50196
3376
adenosine kinase
3.82
down
0.01425

W20276
3477
EST
3.82
down
0.00033

T82254
3228
EST
3.82
down
0.00091

D45529
1662
EST
3.82
down
0.00193

AA043501
98
v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog
3.81
down
0.01304

AA376875
770
monoamine oxidase A
3.8
down
0.02746

AA430108
1013
EST
3.8
down
0.04484

AA598746
1437
EST
3.8
down
0.02667

AA046840
115
CCAAT/enhancer binding protein (C/EBP), delta
3.79
down
0.3319

N21646
2445
EST
3.79
down
0.00079

N66763
2618
EST
3.79
down
0.03015

R97798
3006
EST
3.79
down
0.00015

U73514
3418
hydroxyacyl-Coenzyme A dehydrogenase, type II
3.79
down
0.01392

HG2090-HT2152

CD163 antigen
3.79
down
0.01078

W45259
3519
EST
3.78
down
0.00069

AA398221
790
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta
3.78
down
0.00019

AA449297
1121
EST
3.78
down
0.00039

AA076249
169
EST
3.78
down
0.00029

AA262349
607
EST
3.78
down
0.00043

X75252
3790
prostatic binding protein
3.78
down
0.00231

AA393961
777
EST
3.77
down
0.01029

W86756
3627
retinoid X receptor, alpha
3.77
down
0.02472

J03507
2095
complement component 7
3.77
down
0.00184

X52541
3721
early growth response 1
3.77
down
0.00894

N23817
2457
EST
3.76
down
0.00288

T74884
3216
EST
3.76
down
0.0547

X77548
3795
nuclear receptor coactivator 4
3.76
down
0.00758

F03200
1783
EST
3.75
down
0.01805

R22196
2798
EST
3.75
down
0.02867

R02371
2755
EST
3.75
down
0.00009

M86826
2412
insulin-like growth factor binding protein, acid labile subunit
3.75
down
0.01157

HG4322-HT4592

tubulin, beta polypeptide
3.75
down
0.00554

AA059489
145
RGC32 protein
3.74
down
0.00734

AA010530
25
EST
3.74
down
0.0481

D80312
1730
EST
3.74
down
0.01909

AA426168
960
KIAA0805 protein
3.73
down
0.01477

H51340
1941
EST
3.73
down
0.02643

AA455367
1176
DKFZP586F1018 protein
3.73
down
0.00202

AA481526
1329
EST
3.73
down
0.00002

AA491001
1386
EST
3.73
down
0.01957

D60670
1702
EST
3.73
down
0.00382

N75072
2688
EST
3.73
down
0.00379

R97302
3002
EST
3.73
down
0.01887

AA410507
884
EST
3.73
down
0.01703

W46404
3525
EST
3.73
down
0.00116

AA459389
1216
tyrosylprotein sulfotransferase 2
3.72
down
0.02252

H16768
1887
EST
3.72
down
0.00688

N54604
2569
EST
3.72
down
0.00741

N62443
2589
EST
3.72
down
0.01717

H49415
1938
EST
3.72
down
0.0005

N40188
2512
EST
3.72
down
0.01771

R05309
2758
EST
3.72
down
0.0008

AA428006
984
DKFZP564B167 protein
3.71
down
0.02325

AA463311
1248
EST
3.71
down
0.04902

N30856
2484
solute carrier family 19 (thiamine transporter), member 2
3.71
down
0.00393

S62539
3021
insulin receptor substrate 1
3.7
down
0.01307

AA179387
379
DKFZP434N126 protein
3.7
down
0.01588

AA235288
494
PTPL1-associated RhoGAP 1
3.7
down
0.00643

AA598926
1441
EST
3.7
down
0.00432

AA099589
210
GDP dissociation inhibitor 2
3.7
down
0.04069

AA382975
773
EST
3.7
down
0.00131

L15702
2165
B-factor, properdin
3.7
down
0.04693

D13705
1610
cytochrome P450, subfamily IVA, polypeptide 11
3.7
down
0.00038

X14787
3701
thrombospondin 1
3.69
down
0.01115

AA125861
243
EST
3.69
down
0.01547

AA460916
1233
EST
3.69
down
0.04841

AA156336
341
nuclear receptor co-repressor 1
3.69
down
0.01276

H41280
1925
EST
3.68
down
0.00455

R00843
2750
fragile histidine triad gene
3.68
down
0.03578

Z39431
3904
KIAA1086 protein
3.68
down
0.0013

AA426156
959
EST
3.67
down
0.00153

Z11737
3860
flavin containing monooxygenase 4
3.67
down
0.00632

AA283758
670
EST
3.67
down
0.04293

H66840
1978
EST
3.67
down
0.0143

W87824
3634
EST
3.67
down
0.01559

AA287122
686
EST
3.66
down
0.00161

L76927
2228
galactokinase 1
3.66
down
0.00999

AA031548
69
cell division cycle 42 (GTP-binding protein, 25kD)
3.65
down
0.03029

AA400259
813
EST
3.65
down
0.00476

H25124
1903
EST
3.65
down
0.00004

AA279802
631
EST
3.65
down
0.03366

solute carrier family 6 (neurotransmitter transporter, betaine/GABA),

U27699
3339
member 12
3.65
down
0.00381

C02460
1562
EST
3.64
down
0.02705

Z29481
3874
3-hydroxyanthranilate 3,4-dioxygenase
3.64
down
0.00096

AA281545
645
EST
3.64
down
0.00002

AA235811
502
EST
3.64
down
0.01272

D86062
1752
ES1 (zebrafish) protein, human homolog of
3.63
down
0.0001

Z41042
3925
EST
3.63
down
0.00943

N69299
2648
EST
3.63
down
0.03776

AA044622
103
EST
3.62
down
0.03789

AA393825
776
EST
3.62
down
0.0065

D80217
1727
H91620p protein
3.61
down
0.01973

N45232
2516
EST
3.61
down
0.01308

U48959
3371
myosin, light polypeptide kinase
3.61
down
0.00084

F09058
1799
EST
3.6
down
0.00595

T90531
3249
EST
3.6
down
0.00301

AA025930
52
EST
3.59
down
0.00372

AA235765
501
KIAA0214 gene product
3.59
down
0.01148

D80905
1735
EST
3.59
down
0.0007

H99935
2085
interleukin 6 signal transducer (gp130, oncostatin M receptor)
3.59
down
0.00366

AA242766
523
EST
3.58
down
0.0151

AA441791
1065
EST
3.58
down
0.00357

F10640
1821
EST
3.58
down
0.00152

AA282886
663
EST
3.57
down
0.00049

AA416723
906
EST
3.57
down
0.01042

H98977
2073
EST
3.57
down
0.00298

T33011
3103
EST
3.57
down
0.02486

T41232
3121
EST
3.57
down
0.00846

T91348
3253
EST
3.57
down
0.00011

AA427778
978
EST
3.57
down
0.00368

H04142
1836
EST
3.57
down
0.01906

R40556
2842
EST
3.57
down
0.00184

AA032250
73
EST
3.56
down
0.0009

R21232
2797
EST
3.56
down
0.00246

AA127444
252
EST
3.56
down
0.0291

H40424
1922
butyrate response factor 1 (EGF-response factor 1)
3.56
down
0.04066

W15528
3474
EST
3.56
down
0.00424

Z39978
3913
EST
3.56
down
0.04051

L76465
2224
hydroxyprostaglandin dehydrogenase 15-(NAD)
3.56
down
0.00688

HG3417-HT3600

GTP cyclohydrolase 1 (dopa-responsive dystonia)
3.56
down
0.00317

R71491
2953
EST
3.55
down
0.01903

AA040291
94
KIAA0669 gene product
3.55
down
0.00308

N49902
2539
EST
3.55
down
0.00455

prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-

N67009
2621
Strausler-Scheinker syndrome, fatal familial insomnia)
3.55
down
0.00956

H25551
1904
EST
3.54
down
0.00366

R51309
2889
KIAA1077 protein
3.54
down
0.04112

AA039806
91
msh (Drosophila) homeo box homolog 1 (formerly homeo box 7)
3.53
down
0.00114

AA194146
407
EST
3.53
down
0.00352

AA037357
85
EST
3.53
down
0.02129

AA287550
689
DKFZP434C171 protein
3.53
down
0.00217

AA094507
201
EST
3.52
down
0.04783

AA496423
1399
WW domain binding protein 2
3.52
down
0.01314

AA421052
929
branched chain alpha-ketoacid dehydrogenase kinase
3.52
down
0.00869

X94563
3828
EST
3.52
down
0.00928

W07723
3470
EST
3.51
down
0.00026

X52150
3719
arylsulfatase A
3.51
down
0.00113

AA055992
136
calumenin
3.51
down
0.00604

N64436
2608
EST
3.51
down
0.00441

R26904
2804
EST
3.51
down
0.00058

L29008
2189
sorbitol dehydrogenase
3.51
down
0.00825

U79716
3436
reelin
3.51
down
0.00053

AA435591
1038
kinesin family member 3B
3.5
down
0.0001

R12579
2789
EST
3.5
down
0.00137

AA428863
991
EST
3.5
down
0.01726

AA400780
818
EST
3.5
down
0.00107

U44111
3362
histamine N-methyltransferase
3.5
down
0.00942

U46689
3365
aldehyde dehydrogenase 10 (fatty aldehyde dehydrogenase)
3.5
down
0.01292

Y08374
3850
chitinase 3-like 1 (cartilage glycoprotein-39)
3.5
down
0.04208

H42053
1927
EST
3.49
down
0.01057

AA489061
1367
EST
3.49
down
0.00223

AA400831
819
EST
3.49
down
0.00105

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase

L07033
2144
(hydroxymethylglutaricaciduria)
3.49
down
0

AA056247
138
EST
3.48
down
0.03277

AA496914
1401
v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog
3.48
down
0.00361

H13696
1882
EST
3.48
down
0.01796

F08941
1798
EST
3.48
down
0.00428

T91161
3252
EST
3.48
down
0.00002

M60974
2368
growth arrest and DNA-damage-inducible, alpha
3.48
down
0.00209

AA069456
149
KIAA0438 gene product
3.47
down
0.02718

AA218727
445
EST
3.47
down
0.00125

TEK tyrosine kinase, endothelial (venous malformations, multiple

H02848
1831
cutaneous and mucosal)
3.47
down
0.0089

AA282238
656
EST
3.47
down
0.00677

AA092596
197
bone morphogenetic protein 6
3.46
down
0.02532

U84569
3444
chromosome 21 open reading frame 2
3.46
down
0.01844

R52949
2896
EST
3.46
down
0.00395

W85886
3618
EST
3.46
down
0.00814

AA455896
1181
glypican 1
3.46
down
0.00887

N93155
2728
calmodulin 1 (phosphorylase kinase, delta)
3.46
down
0.00031

N59231
2581
pyruvate carboxylase
3.45
down
0.02066

W73194
3587
dermatopontin
3.45
down
0.02211

N54511
2568
KIAA0265 protein
3.45
down
0.03362

phosphorylase, glycogen; liver (Hers disease, glycogen storage

M14636
2262
disease type VI)
3.45
down
0.00133

dystrophin (muscular dystrophy, Duchenne and Becker types),

includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268,

M18533
2284
DXS269, DXS270, DXS272
3.45
down
0.00313

M81182
2403
ATP-binding cassette, sub-family D (ALD), member 3
3.45
down
0.00499

M23161
2298
EST
3.44
down
0.00733

AA427819
980
midline 2
3.44
down
0.00063

AA430047
1011
EST
3.44
down
0.0016

AA621235
1517
EST
3.44
down
0.0021

AA451911
1139
EST
3.44
down
0.00221

H89514
2023
protein kinase, cAMP-dependent, catalytic, alpha
3.44
down
0.00435

AA017192
37
EST
3.43
down
0.04865

AA235618
499
EST
3.43
down
0.02127

H99393
2076
endothelin receptor type B
3.43
down
0.00093

AF005039
1548
secretory carrier membrane protein 3
3.42
down
0.04953

AA234831
491
EST
3.42
down
0.00206

AA620830
1509
DKFZP564I122 protein
3.42
down
0.02421

N70005
2652
EST
3.42
down
0.04229

T96969
3263
EST
3.42
down
0.00053

AA279112
622
EST
3.42
down
0.01444

H82966
2011
apolipoprotein B (including Ag(x) antigen)
3.42
down
0.00769

AA505198
1419
EST
3.41
down
0.0343

AA429478
998
EST
3.41
down
0.02599

AA463195
1245
EST
3.41
down
0.00413

AA476352
1284
EST
3.41
down
0.02233

F02094
1775
ecotropic viral integration site 5
3.41
down
0.00495

H87144
2016
EST
3.41
down
0.00387

U86529
3450
glutathione S-transferase zeta 1 (maleylacetoacetate isomerase)
3.41
down
0.0118

N49113
2534
EST
3.4
down
0.00162

AA127514
253
EST
3.4
down
0.00045

N69216
2645
EST
3.4
down
0.00497

methylenetetrahydrofolate dehydrogenase (NADP+ dependent),

methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate

J04031
2103
synthetase
3.4
down
0.00786

L49169
2221
FBJ murine osteosarcoma viral oncogene homolog B
3.4
down
0.01193

M30269
2323
nidogen (enactin)
3.4
down
0.00026

U21931
3325
fructose-bisphosphatase 1
3.4
down
0.00709

Y00097
3841
annexin A6
3.4
down
0.00233

AA047290
118
EST
3.39
down
0.00024

AA250744
536
EST
3.39
down
0.01137

H26763
1907
EST
3.39
down
0.04188

M30185
2321
cholesteryl ester transfer protein, plasma
3.39
down
0.00089

M25280
2306
selectin L (lymphocyte adhesion molecule 1)
3.39
down
0.004

AA463946
1254
pigment epithelium-derived factor
3.38
down
0.0018

AA279937
634
EST
3.38
down
0.02719

AA426468
966
EST
3.38
down
0.0099

syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated,

J04621
2113
fibroglycan)
3.38
down
0.00275

AA461458
1241
EST
3.37
down
0.02427

R17762
2794
EST
3.37
down
0.01822

R43166
2846
EST
3.37
down
0.00919

R97711
3004
EST
3.37
down
0.00838

AA112209
223
acyl-Coenzyme A dehydrogenase, long chain
3.37
down
0.00084

SWI/SNF related, matrix associated, actin dependent regulator of

M88163
2415
chromatin, subfamily a, member 1
3.37
down
0.00098

U02020
3276
pre-B-cell colony-enhancing factor
3.37
down
0.01112

N48180
2525
EST
3.36
down
0.00543

T16269
3066
EST
3.36
down
0.00282

AA134549
288
EST
3.36
down
0.03438

AA458923
1207
EST
3.36
down
0.00421

D80408
1731
EST
3.36
down
0.00102

AA293485
718
EST
3.36
down
0.02799

W31478
3495
EST
3.36
down
0.01511

sphingomyelin phosphodiesterase 1, acid lysosomal (acid

M59916
2365
sphingomyelinase)
3.36
down
0.0038

androgen receptor (dihydrotestosterone receptor; testicular

M23263
2300
feminization; spinal and bulbar muscular atrophy; Kennedy disease)
3.35
down
0.02551

H83451
2014
EST
3.35
down
0.00498

W90560
3644
EST
3.35
down
0.00388

AA456326
1191
EST
3.35
down
0.00489

Z38192
3882
EST
3.35
down
0.00184

AA284721
677
EST
3.34
down
0.03296

D59344
1695
EST
3.34
down
0.01337

N47469
2521
EST
3.34
down
0.00329

N22854
2451
CASP2 and RIPK1 domain containing adaptor with death domain
3.34
down
0.0084

N54399
2565
EST
3.34
down
0.00048

U82468
3441
tubby like protein 1
3.34
down
0.0097

AA460047
1226
EST
3.33
down
0.04011

AA001604
4
EST
3.33
down
0.0215

AA121140
235
EST
3.33
down
0.00058

HG2743-HT2846

caldesmon 1
3.33
down
0.00135

N51737
2546
mitogen-activated protein kinase kinase kinase 12
3.32
down
0.00376

AA430026
1007
EST
3.31
down
0.00786

H06166
1854
EST
3.31
down
0.03778

AA062744
147
EST
3.31
down
0.01909

W81079
3608
EST
3.31
down
0.0167

AA227480
456
pim-2 oncogene
3.31
down
0.02413

AA463876
1252
EST
3.31
down
0.00109

H09167
1860
KIAA0195 gene product
3.31
down
0.00313

H98822
2070
EST
3.31
down
0.00174

R92458
2985
hemoglobin, gamma G
3.31
down
0.00763

AA453917
1159
EST
3.3
down
0.01896

M61854
2370
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase)
3.3
down
0.04185

AA281796
650
mannose-P-dolichol utilitzation defect 1
3.3
down
0.04108

F09353
1802
solute carrier family 5 (inositol transporters), member 3
3.3
down
0.02841

N27563
2472
EST
3.3
down
0.00021

R01081
2752
EST
3.3
down
0.00839

H25836
1905
tumor necrosis factor (ligand) superfamily, member 10
3.3
down
0.03125

AA452549
1146
platelet-derived growth factor receptor, alpha polypeptide
3.3
down
0.04155

U28833
3340
Down syndrome candidate region 1
3.3
down
0.00306

T23680
3083
calcium channel, voltage-dependent, gamma subunit 3
3.29
down
0.0003

AA429038
995
EST
3.29
down
0.00927

AA490882
1381
EST
3.29
down
0.00319

AA460128
1227
similar to S. pombe dim1+
3.28
down
0.01299

AA496053
1396
EST
3.28
down
0.00095

T52564
3140
EST
3.28
down
0.01506

T55547
3147
EST
3.28
down
0.00047

Z38777
3892
nuclear receptor binding factor-2
3.28
down
0.022

AA235507
498
golgi autoantigen, golgin subfamily a, 5
3.28
down
0.00249

prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-

X83416
3808
Strausler-Scheinker syndrome, fatal familial insomnia)
3.28
down
0.00221

H04242
1837
RAB5B, member RAS oncogene family
3.27
down
0.04826

N52322
2552
EST
3.27
down
0.00933

H63251
1972
KIAA0606 protein; SCN Circadian Oscillatory Protein (SCOP)
3.27
down
0.02455

AA281930
651
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
3.27
down
0.02329

X02160
3668
insulin receptor
3.27
down
0.0007

C15871
1575
EST
3.26
down
0.00046

AA447617
1103
EST
3.26
down
0.04687

AA464603
1260
EST
3.26
down
0.0007

Z39818
3909
EST
3.26
down
0.00089

Z84718
3949
EST
3.26
down
0.02252

AA598675
1433
EST
3.25
down
0.03934

N93191
2729
EST
3.25
down
0.00232

H09959
1869
choline kinase
3.25
down
0.00225

H79820
2004
EST
3.25
down
0.01466

AA070090
152
EST
3.24
down
0.00804

AA406435
877
EST
3.24
down
0.00941

W60186
3554
EST
3.24
down
0.00228

H67094
1979
EST
3.24
down
0.00075

R39234
2834
EST
3.24
down
0.0412

T54160
3144
EST
3.24
down
0.00168

T72629
3208
EST
3.24
down
0.00556

W87480
3630
STAT induced STAT inhibitor-2
3.24
down
0.01063

branched chain keto acid dehydrogenase E1, alpha polypeptide

Z14093
3862
(maple syrup urine disease)
3.24
down
0.00301

cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-

N54792
2570
N-acetylneuraminate monooxygenase)
3.23
down
0.0099

AA076238
168
EST
3.23
down
0.00395

AA088698
188
EST
3.23
down
0.02543

AA281591
646
EST
3.23
down
0.00895

N67096
2622
EST
3.23
down
0.00446

U51903
3386
IQ motif containing GTPase activating protein 2
3.23
down
0.00242

AA436880
1058
EST
3.22
down
0.00699

H26417
1906
EST
3.22
down
0.03672

N53352
2557
EST
3.22
down
0.00416

AA447740
1106
EST
3.22
down
0.02518

HG3510-HT3704

nuclear receptor subfamily 2, group F, member 1
3.22
down
0.00034

HG3431-HT3616

decorin
3.22
down
0.01941

AA443993
1086
EST
3.21
down
0.02948

T65972
3176
EST
3.21
down
0.04847

S52028
3018
cystathionase (cystathionine gamma-lyase)
3.21
down
0.00476

cytochrome P450, subfamily IIA (phenobarbital-inducible),

M33318
2339
polypeptide 6
3.21
down
0.01621

AA348466
756
regulator of G-protein signalling 5
3.2
down
0.00571

AA459293
1213
EST
3.2
down
0.0001

H27330
1909
EST
3.2
down
0.00067

AA046457
111
EST
3.2
down
0.00513

AA234916
492
EST
3.2
down
0.00799

R10662
2786
mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2)
3.2
down
0.0005

H46990
1933
cytochrome P450, subfamily IIE (ethanol-inducible)
3.2
down
0.00095

solute carrier family 1 (glial high affinity gluamate transporter),

U01824
3275
member 2
3.2
down
0.00021

X61123
3750
B-cell translocation gene 1, anti-proliferative
3.2
down
0.00796

H10482
1870
EST
3.19
down
0.01611

solute carrier family 9 (sodium/hydrogen exchanger), isoform 3

U82108
3440
regulatory factor 2
3.19
down
0.01545

AA084668
180
ubiquitin-like 3
3.19
down
0.0419

H12257
1879
EST
3.19
down
0.0069

N74558
2686
EST
3.19
down
0.00247

R69031
2940
EST
3.19
down
0.00798

AA191488
398
solute carrier family 31 (copper transporters), member 1
3.19
down
0.00013

U67963
3409
lysophospholipase-like
3.19
down
0.00029

M24283
2303
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
3.19
down
0.04985

AA157520
347
EST
3.18
down
0.00516

AA418098
920
cAMP responsive element binding protein-like 2
3.18
down
0.03824

AA005202
12
retinol-binding protein 4, interstitial
3.18
down
0.00106

AA227901
459
SEC24 (S. cerevisiae) related gene family, member B
3.18
down
0.00397

H40534
1923
EST
3.18
down
0.01381

AA236942
519
EST
3.18
down
0

hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A

thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta

D16481
1621
subunit
3.18
down
0.00695

D31225
1641
EST
3.17
down
0.01073

H95358
2049
EST
3.17
down
0.00182

H89893
2025
EST
3.17
down
0.00658

N48602
2528
EST
3.17
down
0.02913

T86464
3236
EST
3.17
down
0.00498

AA125856
242
EST
3.17
down
0.01545

H93562
2038
proline synthetase co-transcribed (bacterial homolog)
3.17
down
0.00113

Y10659
3856
interleukin 13 receptor, alpha 1
3.17
down
0.00095

X67235
3770
hematopoietically expressed homeobox
3.17
down
0.0045

AA004231
7
EST
3.16
down
0.03067

F04335
1787
EST
3.16
down
0.0058

T10822
3054
EST
3.16
down
0.00635

T79842
3224
EST
3.16
down
0.03159

AA180356
382
EST
3.16
down
0.00917

AA207123
430
immunoglobulin superfamily, member 3
3.16
down
0.00328

AA397914
783
EST
3.16
down
0.00336

AA599954
1459
cell cycle progression 8 protein
3.15
down
0.00021

H06063
1852
chondroitin sulfate proteoglycan 3 (neurocan)
3.15
down
0.00599

W61000
3557
EST
3.15
down
0.03143

J02888
2089
NAD(P)H menadione oxidoreductase 2, dioxin-inducible
3.15
down
0.02385

U62389
3401
isocitrate dehydrogenase 1 (NADP+), soluble
3.15
down
0.03949

X04729
3679
plasminogen activator inhibitor, type 1
3.15
down
0.01337

N45998
2519
EST
3.14
down
0.00337

R54416
2900
EST
3.14
down
0.00236

AA446651
1093
EST
3.14
down
0.01902

AA608671
1466
EST
3.14
down
0.04543

W51951
3539
dCMP deaminase
3.14
down
0.01691

AA101055
213
leptin receptor
3.14
down
0.0071

J04615
2112
SNRPN upstream reading frame
3.14
down
0.02928

M20902
2292
apolipoprotein C-I
3.14
down
0.0389

solute carrier family 25 (mitochondrial carrier; citrate transporter),

L77567
2229
member 1
3.14
down
0.04095

AA487161
1353
ubiquilin 2
3.13
down
0.00023

H19504
1895
EST
3.13
down
0.04948

N27524
2471
EST
3.13
down
0.00216

N31952
2489
EST
3.13
down
0.01481

N25193
2463
EST
3.13
down
0.01955

N63688
2602
EST
3.13
down
0.002

N99866
2747
EST
3.13
down
0.04148

AA452915
1152
EST
3.13
down
0.00561

AA477119
1289
EST
3.13
down
0.0338

U25182
3332
thioredoxin peroxidase (antioxidant enzyme)
3.13
down
0.02543

U79294
3434
Phosphatidic acid phosphatase type 2b
3.13
down
0.00129

X17025
3712
isopentenyl-diphosphate delta isomerase
3.13
down
0.0043

L38490
2207
ADP-ribosylation factor 4-like
3.13
down
0.01306

AA402095
835
EST
3.12
down
0.01412

AA479132
1309
EST
3.12
down
0.00876

R67751
2938
EST
3.12
down
0.00319

AA490214
1376
EST
3.12
down
0.02382

H09594
1868
EST
3.12
down
0.00231

H59141
1963
EST
3.12
down
0.00293

T23430
3079
EST
3.12
down
0.00949

T82259
3229
EST
3.12
down
0.01122

Z38435
3887
ribosomal protein L21
3.12
down
0.03617

AA074891
162
EST
3.12
down
0.01897

AA476346
1283
EST
3.12
down
0.01067

H05072
1843
EST
3.12
down
0.01248

AA405907
867
EST
3.12
down
0

N79435
2700
chromosome 15 open reading frame 3
3.12
down
0.00861

R44761
2857
aryl hydrocarbon receptor nuclear translocator
3.12
down
0.02663

D13814
1611
angiotensin receptor 1,angiotensin receptor 1B
3.12
down
0.00101

X95876
3833
G protein-coupled receptor 9
3.12
down
0.001

AA298180
726
EST
3.11
down
0.00747

W35309
3499
EST
3.11
down
0.029

AA243595
530
EST
3.11
down
0.008

AA280791
640
eukaryotic translation initiation factor 5
3.11
down
0.03339

T68426
3185
CD81 antigen (target of antiproliferative antibody 1)
3.11
down
0.01634

AA401343
828
EST
3.11
down
0.01929

AA454170
1163
EST
3.11
down
0.03

M30257
2322
vascular cell adhesion molecule 1
3.11
down
0.00064

H67840
1980
EST
3.1
down
0.00528

AA455962
1182
EST
3.1
down
0.03905

AA609576
1486
EST
3.1
down
0.00266

H06144
1853
EST
3.1
down
0.00745

H47391
1935
EST
3.1
down
0.03807

N31598
2487
EST
3.1
down
0.00203

N95585
2742
EST
3.1
down
0.0083

AA457377
1201
EST
3.1
down
0.00549

HG3998-HT4268

glycerol-3-phosphate dehydrogenase 1 (soluble)
3.1
down
0.00523

AA247453
533
EST
3.09
down
0.0015

AA284558
674
Nck, Ash and phospholipase C binding protein
3.09
down
0.00027

U06863
3287
follistatin-like 1
3.09
down
0.00091

AA282179
655
EST
3.09
down
0.01693

AA621430
1525
doublecortex; lissencephaly, X-linked (doublecortin)
3.09
down
0.00024

H82838
1971
EST
3.09
down
0.03201

W67199
3566
EST
3.09
down
0.01528

AA400246
810
mitogen-activated protein kinase-activated protein kinase 2
3.09
down
0.00476

AA412034
894
EST
3.09
down
0.02309

AA443934
1083
GTP-binding protein Rho7
3.09
down
0.00214

AA456687
1197
EST
3.08
down
0.01189

R80573
2972
EST
3.08
down
0.02126

R82229
2974
phosphatidylserine decarboxylase
3.08
down
0.03455

CD36 antigen (collagen type I receptor, thrombospondin receptor)-

W52581
3540
like 2 (lysosomal integral membrane protein II)
3.08
down
0.00091

N90584
2713
EST
3.08
down
0.02602

AA126059
246
EST
3.08
down
0.00706

AA485326
1342
ATP-binding cassette, sub-family D (ALD), member 4
3.08
down
0.00415

N21550
2443
EST
3.08
down
0.00006

AA412184
898
EST
3.08
down
0.00012

AA416740
907
EST
3.08
down
0.01592

U73682
3419
meningioma expressed antigen 6 (coiled-coil proline-rich)
3.08
down
0.01249

M16750
2273
pim-1 oncogene
3.08
down
0.01811

Z26491
3870
catechol-O-methyltransferase
3.08
down
0.00877

D58231
1692
ubiquitin-like 3
3.07
down
0.0002

T94862
3257
EST
3.07
down
0.01417

N34441
2495
EST
3.07
down
0.00186

T16175
3063
protein tyrosine phosphatase, non-receptor type substrate 1
3.07
down
0.01007

H39119
1919
EST
3.06
down
0.03349

R56602
2906
Ig superfamily protein
3.06
down
0.02464

T49061
3134
EST
3.06
down
0.00768

N68993
2640
EST
3.06
down
0.00867

U36922
3351
EST
3.06
down
0.01388

U69141
3413
glutaryl-Coenzyme A dehydrogenase
3.06
down
0.00053

AA253455
565
EST
3.05
down
0.00533

AA338512
742
EST
3.05
down
0.03427

AA487606
1358
EST
3.05
down
0.00291

R02752
2757
EST
3.05
down
0.00362

M12529
2244
apolipoprotein E
3.05
down
0.03776

T30341
3100
EST
3.04
down
0.04567

AA047187
117
EST
3.04
down
0.04306

R07637
2777
EST
3.04
down
0.00118

R51256
2888
EST
3.04
down
0.00286

W42483
3507
EST
3.04
down
0.02518

X87344
3814
EST
3.04
down
0.02779

AA040270
93
EST
3.03
down
0.01367

R05490
2760
SEC24 (S. cerevisiae) related gene family, member B
3.03
down
0.00317

N93246
2730
EST
3.03
down
0.00049

phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog

L20965
2175
phosphodiesterase E2)
3.02
down
0.01177

protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65),

H57850
1958
beta isoform
3.02
down
0.00123

W61319
3558
EST
3.02
down
0.00031

AA599526
1453
cartilage associated protein
3.02
down
0.00043

AA609572
1484
EST
3.02
down
0.01534

AA490890
1382
EST
3.02
down
0.00007

X76105
3791
death-associated protein
3.02
down
0.00944

M92843
2420
zinc finger protein homologous to Zfp-36 in mouse
3.02
down
0.04958

D01686
1557
EST
3.01
down
0.00048

T92950
3255
EST
3.01
down
0.00497

AA349836
760
EST
3.01
down
0.00911

AA401151
827
lysozyme (renal amyloidosis)
3.01
down
0.0051

AA459256
1212
lectin, mannose-binding, 1
3.01
down
0.00094

AA215585
442
nucix (nucleoside diphosphate linked moiety X)-type motif 3
3
down
0.03027

AA292711
711
EST
3
down
0.01053

AA410181
881
EST
3
down
0.00268

W70313
3575
EST
3
down
0.00643

[0134]

10

TABLE 7A

Up in HCC vs Normal Sample Set 2

Fold

Fragment Name
SEQ ID:
Known Gene Name
Change
Direction
Pvalue

N33920
2492
diubiquitin
50.29
up
0

Y00705
3847
serine protease inhibitor, Kazal type 1
28.88
up
0.00003

AA398908
801
EST
20.72
up
0.00114

AA099404
208
EST
20.22
up
0

AA610116
1499
tetraspan NET-6 potein
16.35
up
0.00249

N26904
2468
EST
15.38
up
0.00077

R91819
2983
EST
12.81
up
0.00037

AA505133
1417
solute carrier family 2 (facilitated glucose transporter), member 3
12.21
up
0.00169

AA405791
864
EST
11.79
up
0.00587

N59536
2585
EST
11.68
up
0.00484

AA055896
135
collagen, type V, alpha 1
10.87
up
0.00907

H99879
2084
EST
10.81
up
0.001

L47125
2218
glypican 3
10.69
up
0.04129

AA430032
1009
pituitary tumor-transforming 1
10.67
up
0.00052

Z37987
3879
glypican 3
10.66
up
0.02304

J03464
2094
collagen, type I, alpha 2
10.37
up
0.00979

W45320
3520
KRAB-associated protein 1
10.05
up
0.00002

M94250
2425
midkine (neurite growth-promoting factor 2)
9.86
up
0.02104

AA428172
986
Notch (Drosophila) homolog 3
9.63
up
0.00195

AA620881
1510
trinucleotide repeat containing 3
9.49
up
0.00062

AA142857
307
EST
9.48
up
0.00376

D51276
1678
leukemia-associated phosphoprotein p18 (stathmin)
9.42
up
0.00015

AA156187
339
ATP synthase, H + transporting, mitochondrial F0 complex, subunit b, isoform 1
9.38
up
0.02007

D31094
1639
G8 protein
9.37
up
0.0048

AA148977
322
EST
9.3
up
0.00002

F08876
1797
EST
9.06
up
0

AA232837
465
EST
8.85
up
0.0048

AA429472
997
DKFZP434P106 protein
8.78
up
0.00063

T24068
3087
EST
8.65
up
0.00118

AA149889
326
neighbor of A-kinase anchoring protein 95
8.55
up
0.00224

AA398926
802
EST
8.25
up
0.00066

C01766
1559
EST
8.18
up
0.00505

N36432
2506
erythrocyte membrane protein band 4.1-like 2
7.95
up
0.00067

AA452724
1149
programmed cell death 5
7.7
up
0.00085

AA401965
833
tumor suppressor deleted in oral cancer-related 1
7.58
up
0.00089

AA620553
1504
flap structure-specific endonuclease 1
7.56
up
0.00101

AA024658
47
ribosomal protein S19
7.55
up
0.00592

AA136269
298
EST
7.5
up
0.00014

H78211
2001
EST
7.5
up
0.02674

AA393139
775
geminin
7.44
up
0.00888

AA251792
546
fatty-acid-Coenzyme A ligase, long-chain 4
7.44
up
0.00285

AA417030
914
EST
7.35
up
0.00555

AA394258
779
RD RNA-binding protein
7.27
up
0.00054

AA292765
712
ZW10 interactor
7.24
up
0.00498

T16226
3065
EST
7.23
up
0.00119

H08863
1859
hypothetical protein
7.18
up
0.02102

M12125
2241
tropomyosin 2 (beta)
7.13
up
0.0004

R96924
3000
EST
7.04
up
0.00012

AA243133
525
serine/threonine kinase 15
7.03
up
0.00005

R06986
2775
peptidylprolyl isomerase B (cylophilin B)
7.03
up
0.00628

N93299
2731
nuclear receptor co-repressor 1
6.99
up
0.0371

Z39682
3908
KIAA0954 protein
6.96
up
0.01966

D26129
1635
ribonuclease, RNase A family, 1 (pancreatic)
6.9
up
0.00008

AA280734
639
KIAA0618 gene product
6.83
up
0.001

T58607
3154
EST
6.83
up
0.03711

H97013
2059
ephrin-A4
6.8
up
0.00023

AA283182
668
EST
6.78
up
0.01784

M57710
2357
lectin, galactoside-binding, soluble, 3 (galectin 3)
6.76
up
0.00103

AA434418
1036
KIAA1115 protein
6.75
up
0.0032

AA263032
614
ATP synthase, H + transporting, mitochondrial F0 complex, subunit b, isoform 1
6.73
up
0.04478

AA173755
374
EST
6.73
up
0.00666

AA421951
936
EST
6.69
up
0.00013

W31906
3496
secretagogin
6.62
up
0.00926

AA148885
320
minichromosome maintenance deficient (S. cerevisiae) 4
6.59
up
0.00112

AA159025
353
EST
6.58
up
0.01946

R44617
2856
MyoD family inhibitor
6.54
up
0.02505

W94885
3657
EST
6.53
up
0

L29218
2190
CDC-like kinase 2
6.51
up
0.00019

H99473
2077
regulator of nonsense transcripts 1
6.51
up
0.00025

AA258421
595
hypothetical protein
6.5
up
0.00559

AA454830
1170
DKFZP586M2123 protein
6.48
up
0.00555

R45994
2866
EST
6.48
up
0.00358

AA335191
741
creatine kinase, brain
6.47
up
0.01462

T95057
3258
EST
6.46
up
0.00613

AA011209
30
melanoma-associated antigen recognised by T lymphocytes
6.45
up
0.00088

N73808
2678
EST
6.44
up
0.00352

N62126
2588
EST
6.42
up
0.00109

AA454908
1171
KIAA0144 gene product
6.39
up
0.01835

W80852
3606
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
6.37
up
0.00005

AA043111
97
EST
6.36
up
0.0005

AA446242
1087
EST
6.3
up
0.00169

F04320
1786
replication factor C (activator 1) 4 (37 kD)
6.29
up
0.00042

H94471
2042
occludin
6.26
up
0.00379

AA284945
680
EST
6.25
up
0.0002

J00231
2087
immunoglobulin heavy constant gamma 3 (G3m marker)
6.23
up
0.00177

AA258131
587
putative GTP-binding protein similar to RAY/RAB1C
6.23
up
0.00931

AA291139
695
EST
6.22
up
0.03491

AA459254
1211
EST
6.22
up
0.00001

H10933
1873
EST
6.18
up
0.00003

R48594
2874
EST
6.15
up
0.03831

AA204927
425
tropomyosin 1 (alpha)
6.11
up
0.0014

AA405098
855
EST
6.09
up
0.01224

T47032
3123
partner of RAC1 (arfaptin 2)
6.09
up
0.00019

W81654
3613
SRY (sex determining region Y)-box 13
6.06
up
0.00127

R79246
2968
melanoma adhesion molecule
6.06
up
0.00057

R70801
2949
EST
6.06
up
0.00291

D59355
1696
cytoskeleton-associated protein 1
6.05
up
0.0015

X05610
3682
collagen, type IV, alpha 2
6.04
up
0.00062

F01831
1773
EST
5.95
up
0.00532

D59553
1697
golgin-67
5.95
up
0.00169

Z74616
3947
collagen, type I, alpha 2
5.95
up
0.02212

AA181705
385
EST
5.9
up
0.00023

C01721
1558
phospholipase C, beta 3, neighbor pseudogene
5.89
up
0.0383

T16550
3071
vacuolar protein sorting 45B (yeast homolog)
5.88
up
0.00004

AA282247
657
EST
5.88
up
0.01112

N54841
2571
EST
5.87
up
0.02752

M31303
2327
leukemia-associated phosphoprotein p18 (stathmin)
5.86
up
0.00071

H05084
1844
EST
5.85
up
0.0059

H27188
1908
collagen-binding protein 2 (colligen 2)
5.84
up
0.01826

AA496981
1404
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
5.82
up
0.00521

H59617
1964
EST
5.81
up
0.0115

W42957
3513
calmodulin 2 (phosphorylase kinase, delta)
5.79
up
0.03669

AA282343
658
purine-rich element binding protein B
5.78
up
0.00128

AA455239
1174
chromosome-associated polypeptide C
5.78
up
0.00003

AA234096
479
EST
5.75
up
0.01169

U45285
3363
T-cell, immune regulator 1
5.75
up
0.00006

AA504512
1415
KIAA0943 protein
5.72
up
0.00384

AA443602
1078
EST
5.71
up
0.00736

AA092129
194
EST
5.67
up
0.00011

F02807
1781
KIAA0838 protein
5.67
up
0.02064

N80703
2703
EST
5.65
up
0.0001

AA235448
497
EST
5.62
up
0.00077

AA449073
1117
EST
5.61
up
0.01214

T47325
3124
EST
5.6
up
0.02923

AA135153
291
EST
5.58
up
0.00327

D00596
1590
thymidylate synthetase
5.58
up
0.0098

N72116
2667
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
5.57
up
0.00709

T03580
3045
pyruvate kinase, muscle
5.57
up
0.01344

R07172
2776
EST
5.54
up
0.01322

W78057
3597
EST
5.53
up
0.01231

R72886
2955
KIAA0422 protein
5.5
up
0.00091

AA458878
1204
EST
5.49
up
0.00977

D55716
1686
minichromosome maintenance deficient (S. cerevisiae) 7
5.48
up
0.00003

W26716
3481
non-histone chromosome protein 2 (S. cerevisiae)-like 1
5.47
up
0.00146

AA134052
285
Rab geranylgeranyltransferase, alpha subunit
5.47
up
0.00982

Z74615
3946
collagen, type I, alpha 1
5.47
up
0.00283

AA410469
883
EST
5.45
up
0.00068

R44793
2858
EST
5.4
up
0.00329

AA133666
283
cysteine-rich protein 2
5.35
up
0.00433

W02041
3465
EST
5.34
up
0.00027

U75285
3421
apoptosis inhibitor 4 (survivin)
5.32
up
0.01127

AA416970
912
Mad4 homolog
5.3
up
0.00418

AA102489
219
EST
5.28
up
0.02122

T89703
3243
EST
5.27
up
0.00019

N69263
2647
EST
5.26
up
0.0276

T62918
3168
EST
5.25
up
0.00687

AA226932
453
DKFZP564F0923 protein
5.25
up
0.00612

KIAA1080 protein; Golgi-associated, gamma-adaptin ear containing, ARF-binding

AA007507
18
protein 2
5.23
up
0.00159

AA133527
281
EST
5.23
up
0.00037

AA249819
535
EST
5.22
up
0.00049

T15852
3061
EST
5.21
up
0.00642

R39191
2833
KIAA1020 protein
5.18
up
0.03185

M86752
2411
stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)
5.15
up
0.02881

T17066
3074
SET domain, bifurcated, 1
5.14
up
0.00073

W46846
3529
EST
5.11
up
0.00025

F02254
1777
Fas-activated serine/threonine kinase
5.1
up
0.00329

W86748
3626
EST
5.09
up
0.01882

T53590
3143
cytochrome P450, subfamily XIA (cholesterol side chain cleavage)
5.09
up
0.00002

H41529
1926
EST
5.06
up
0.03309

AA608897
1473
EST
5.05
up
0.01782

AA491188
1387
solute carrier family 2 (facilitated glucose transporter), member 3
5.04
up
0.02291

AA026356
57
EST
5.04
up
0.02483

W46634
3527
EST
5.03
up
0.02152

AA460909
1232
EST
5.02
up
0.01354

AA421562
934
anterior gradient 2 (Xenepus laevis) homolog
5.02
up
0.02818

AA027833
59
EST
5.02
up
0.01123

AA435748
1044
EST
5.01
up
0.01812

R44839
2860
i-beta-1,3-N-acetylglucosaminyltransferase
5
up
0.01812

T67053
3179
EST
5
up
0.01846

AA470156
1276
EST
4.99
up
0.0206

R70005
2943
EST
4.98
up
0.00007

W80763
3605
EST
4.98
up
0.01026

T33508
3105
phosphatidylinositol-4-phosphate 5-kinase, type II, beta
4.96
up
0.00064

AA442054
1067
phospholipase C, gamma 1 (formerly subtype 148)
4.94
up
0.04102

H28333
1912
melanoma adhesion molecule
4.94
up
0.00166

R49476
2882
EST
4.93
up
0.00763

AA291168
696
EST
4.93
up
0.01633

AA410962
887
peroxisome proliferative activated receptor, delta
4.91
up
0.0044

N93798
2737
protein tyrosine phosphatase type IVA, member 3
4.91
up
0.00245

W85875
3617
EST
4.91
up
0.01198

AA089997
189
EST
4.9
up
0.0241

AA482319
1335
putative type II membrane protein
4.9
up
0.00028

AA037433
86
EST
4.9
up
0.0194

W79773
3602
EST
4.89
up
0.00034

AA188378
392
EST
4.88
up
0.01653

AA252060
550
EST
4.88
up
0.00169

F01538
1771
RAP1, GTPase activating protein 1
4.88
up
0.00292

R06251
2763
tumor protein D52-like 2
4.88
up
0.03097

T90190
3246
H1 histone family, member 2
4.88
up
0.00555

AA281599
647
EST
4.87
up
0.00248

T88814
3241
EST
4.87
up
0.00001

W92608
3650
BAI1-associated protein 3
4.84
up
0.00599

AA477549
1291
T-cell, immune regulator 1
4.84
up
0.04096

W73038
3585
EST
4.83
up
0.00902

S78187
3035
cell division cycle 25B
4.83
up
0.00547

N54067
2561
mitogen-activated protein kinase kinase kinase kinase 4
4.82
up
0.00229

W60097
3553
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome
4.82
up
0.04903

AA215299
439
U6 snRNA-associated Sm-like protein LSm7
4.81
up
0.00119

AA497018
1406
adenylate cyclase 1 (brain)
4.81
up
0.00352

AA115735
230
EST
4.8
up
0.02671

C14051
1565
phosphoprotein enriched in astrocytes 15
4.79
up
0.00548

H09271
1862
EST
4.78
up
0.00072

AA482104
1332
non-metastatic cells 3, protein expressed in
4.78
up
0.00135

AA283832
672
EST
4.77
up
0.00156

AA464963
1265
EST
4.77
up
0.00086

R48447
2870
EST
4.76
up
0.00533

AA251299
541
KIAA0014 gene product
4.74
up
0.0252

H64493
1973
immunoglobulin heavy constant gamma 3 (G3m marker)
4.74
up
0.00751

M60784
2366
small nuclear ribonucleoprotein polypeptide A
4.74
up
0.00001

AA146849
313
target of myb1 (chicken) homolog
4.72
up
0.00326

AA179787
380
polyglutamine binding protein 1
4.71
up
0.00725

AA430474
1015
EST
4.69
up
0.00007

Z38462
3889
KIAA0938 protein
4.69
up
0.0142

AA489712
1372
EST
4.69
up
0.00587

R52649
2893
EST
4.69
up
0.00135

AA424487
945
EST
4.68
up
0.0013

D82558
1746
novel centrosomal protein RanBPM
4.67
up
0.00458

X99920
3840
S100 calcium-binding protein A13
4.66
up
0.00113

M35252
2343
transmembrane 4 superfamily member 3
4.65
up
0.04128

U73377
3416
SHC (Src homology 2 domain-containing) transforming protein 1
4.64
up
0.00081

X57129
3740
H1 histone family, member 2
4.63
up
0.00663

L28821
2188
mannosidase, alpha, class 2A, member 2
4.63
up
0.00876

AA431571
1024
EST
4.62
up
0.0174

C14098
1566
EST
4.62
up
0.01654

R96527
2998
KIAA0253 protein
4.62
up
0.00702

AA451877
1138
EST
4.6
up
0.04045

T33489
3104
EST
4.6
up
0.00285

M27830
2314
EST
4.6
up
0.04719

AA621242
1518
hypothetical protein, peptidylprolyl isomerase B (cyclophilin B)
4.59
up
0.00081

M87339
2414
replication factor C (activator 1) 4 (37 kD)
4.59
up
0.00116

H46486
1932
nesca protein
4.57
up
0.00749

AA262477
608
ribonuclease HI, large subunit
4.57
up
0.00724

AA194730
410
EST
4.57
up
0.00801

R49708
2885
EST
4.56
up
0.03767

T34377
3110
potassium voltage-gated channel, shaker-related subfamily, beta member 2
4.55
up
0.00041

AA424029
943
EST
4.54
up
0.02721

AA151435
336
EST
4.52
up
0.01134

kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte

AA086232
186
antigen, antigen detected by monoclonal and antibody IA4))
4.52
up
0.00452

AA280840
641
casein kinase 1, gamma 2
4.51
up
0.0186

AA127741
256
EST
4.49
up
0.0463

H86072
2015
EST
4.49
up
0.01301

AA482224
1334
putative type II membrane protein
4.47
up
0.0001

U47025
3367
phosphorylase, glycogen; brain
4.47
up
0.00037

T30214
3098
EST
4.46
up
0.03654

W70336
3576
EST
4.46
up
0.00023

AA251769
544
EST
4.45
up
0.01431

L17131
2168
high-mobility group (nonhistone chromosomal) protein isoforms I and Y
4.45
up
0.03141

AA001504
2
EST
4.44
up
0.03077

AA215379
440
EST
4.44
up
0.01675

H99587
2079
EST
4.44
up
0.00532

AA487218
1355
EST
4.43
up
0.03198

N75541
2691
EST
4.43
up
0.01059

N73865
2680
EST
4.43
up
0.00177

cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity

L25876
2182
phosphatase)
4.43
up
0.00082

AB002373
1538
KIAA0375 gene product
4.41
up
0.00795

H57709
1956
ribosomal protein L31
4.41
up
0.00091

F13809
1828
tropomyosin 1 (alpha)
4.4
up
0.01221

T79477
3222
death-associated protein 6
4.4
up
0.00074

AA156460
343
EST
4.39
up
0.01223

AA171760
367
EST
4.39
up
0.04582

AA423827
941
chromosome 22 open reading frame 3
4.39
up
0.00345

W28362
3487
KIAA0974 protein
4.38
up
0.00322

W69302
3570
EST
4.37
up
0.00165

AA236672
515
EST
4.37
up
0.00385

AA043959
101
tropomyosin 4
4.37
up
0.01641

AA070827
157
EST
4.37
up
0.02617

W42627
3508
EST
4.37
up
0.00021

D82226
1742
proteasome (prosome, macropain) 26S subunit, ATPase, 4
4.35
up
0.00184

L33930
2198
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
4.35
up
0.03968

AA218663
444
acid-inducible phosphoprotein
4.34
up
0.00161

D59570
1699
EST
4.34
up
0.00487

D60811
1704
EST
4.34
up
0.00217

H70739
1991
EST
4.34
up
0.00106

H97677
2062
EST
4.34
up
0.00753

R92449
2984
KIAA0323 protein
4.34
up
0.00104

R61374
2920
EST
4.33
up
0.01489

N68241
2633
EST
4.32
up
0.00532

AA430048
1012
KIAA0160 protein
4.32
up
0.00279

AA235289
495
RAP2A, member of RAS oncogene family
4.31
up
0.00135

N91773
2718
lysyl oxidase
4.31
up
0.00302

AA429539
999
EST
4.3
up
0.01035

AA399251
804
EST
4.3
up
0.01578

AA461063
1235
EST
4.3
up
0.00074

W86214
3622
EST
4.3
up
0.00194

M19267
2286
tropomyosin 1 (alpha)
4.3
up
0.00893

AA416973
913
EST
4.29
up
0.00155

T16206
3064
EST
4.29
up
0.00868

AA252627
556
chaperonin containing TCP1, subunit 6A (zeta 1), homeo box B5
4.28
up
0.00363

W60486
3555
EST
4.27
up
0.0046

AA478017
1295
zyxin
4.25
up
0.01223

M37583
2349
H2A histone family, member Z
4.25
up
0.00135

T55196
3146
EST
4.24
up
0.00046

AA454597
1166
EST
4.23
up
0.00917

T03749
3047
KIAA1089 protein
4.23
up
0.00776

AA256688
584
EST
4.23
up
0.03094

T16983
3073
cleavage and polyadenylation specific factor 4, 30 kD subunit
4.23
up
0.0106

AA398205
789
EST
4.22
up
0.00059

AA488432
1361
phosphoserine phosphatase
4.2
up
0.00128

R05316
2759
EST
4.2
up
0.00011

AA136547
302
EST
4.19
up
0.00098

AA112679
224
EST
4.19
up
0.00572

R39390
2836
EST
4.18
up
0.0004

D83783
1748
trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit
4.16
up
0.00055

AA291786
704
FE65-LIKE 2
4.15
up
0.00362

AA291659
702
EST
4.15
up
0.00019

H88674
2021
collagen, type I, alpha 2
4.15
up
0.02664

AA488892
1364
EST
4.14
up
0.04766

F01568
1772
EST
4.13
up
0.00084

F04444
1788
EST
4.13
up
0.00944

N70481
2657
EST
4.13
up
0.0099

AA102837
221
EST
4.13
up
0.0067

AA365742
765
tetraspan NET-6 protein
4.12
up
0.00255

R71395
2951
EST
4.12
up
0.03719

AA447574
1102
EST
4.12
up
0.00779

AA400184
809
KIAA0907 protein
4.11
up
0.01123

AA211483
435
EST
4.11
up
0.0365

AA037058
84
laminin, gamma 1 (formerly LAMB2)
4.11
up
0.02264

W44557
3515
chromosome 1 open reading frame 2
4.1
up
0.00433

T62521
3167
EST
4.1
up
0.00392

D38073
1651
minichromosome maintenance deficient (S. cerevisiae) 3
4.1
up
0.01195

N92948
2725
nuclear phosphoprotein similar to S. cerevisiae PWP1
4.09
up
0.0019

AA464414
1258
EST
4.08
up
0.02299

AA142858
308
EST
4.07
up
0.0022

AA610089
1498
U4/U6-associated RNA splicing factor
4.07
up
0.00361

Z39200
3899
EST
4.07
up
0.00075

AA443802
1081
EST
4.07
up
0.01546

AA453783
1158
EST
4.07
up
0.00786

AA053680
130
high-mobility group protein 2-like 1
4.07
up
0.03144

L03411
2134
RD RNA-binding protein
4.06
up
0.00467

AA405505
860
RNA helicase family
4.05
up
0.00747

AA293420
717
EST
4.05
up
0.01189

AA400643
817
GAS2-related on chromosome 22
4.04
up
0.03751

AA609008
1475
EST
4.04
up
0.00002

N56935
2574
EST
4.04
up
0.00797

AA446581
1090
DKFZP564P0462 protein
4.04
up
0.00479

H52937
1944
roundabout (axon guidance receptor, Drosophila) homolog 1
4.02
up
0.00163

D42040
1657
female sterile homeotic-related gene 1 (mouse homolog)
4.02
up
0.00389

W04550
3469
EST
4.01
up
0.00349

AA460665
1230
EST
4.01
up
0.01866

AA463254
1247
histone deacetylase 3
4.01
up
0.01856

U85625
3447
ribonuclease 6 precursor
4
up
0.01664

T77733
3218
tubulin, gamma 1
4
up
0.00526

AA464043
1255
EST
3.99
up
0.00056

N69390
2649
EST
3.99
up
0.00016

X54941
3729
CDC28 protein kinase 1
3.99
up
0.0016

HG2259-HT2348

tubulin, alpha 1 (testis specific), tubulin, alpha, ubiquitous
3.99
up
0.00945

AA425852
958
EST
3.98
up
0.02796

D84557
1749
minichromosome maintenance deficient (mis5, S. pombe) 6
3.97
up
0.0017

AA338760
744
EST
3.96
up
0.01307

R45569
2863
DKFZP547E1010 protein
3.96
up
0.00259

X17567
3716
small nuclear ribonucleoprotein polypeptides B and B1
3.96
up
0.00317

M68864
2389
ORF
3.95
up
0.00144

X53331
3724
matrix Gla protein
3.95
up
0.0151

AA258614
599
EST
3.94
up
0.0048

T65957
3175
ribosomal protein S3A
3.94
up
0.04187

AA435665
1040
EST
3.94
up
0.00274

M32977
2336
vascular endothelial growth factor
3.93
up
0.04917

F10199
1813
EST
3.93
up
0.03209

AA256606
581
EST
3.92
up
0.03087

R61557
2921
KIAA0100 gene product
3.9
up
0.00292

T33859
3108
KIAA0365 gene product
3.9
up
0.0019

U18018
3316
ets variant gene 4 (E1A enhancer-binding protein, E1AF)
3.9
up
0.0403

T78922
3221
stem cell growth factor; lymphocyte secreted C-type lectin
3.89
up
0.00604

D63478
1711
KIAA0144 gene product
3.89
up
0.00253

AA320369
735
chromosome 19 open reading frame 3
3.88
up
0.00452

AA598405
1424
membrane interacting protein of RGS16
3.87
up
0.00649

AA127444
252
EST
3.87
up
0.01751

AA465000
1266
EST
3.86
up
0.00431

D80420
1732
ubiquinol-cytochrome c reductase hinge protein
3.86
up
0.00412

T10698
3053
EST
3.86
up
0.00195

X74801
3788
chaperonin containing TCP1, subunit 3 (gamma)
3.86
up
0.00453

AA451680
1136
hepatocellular carcinoma associated protein; breast cancer associated gene 1
3.85
up
0.0018

L76191
2222
interleukin-1 receptor-associated kinase 1
3.85
up
0.00152

N68018
2630
TBP-associated factor 172
3.84
up
0.00277

AA132032
271
trinucleotide repeat containing 1
3.84
up
0.01136

N67815
2626
EST
3.84
up
0.00439

D14657
1615
KIAA0101 gene product
3.84
up
0.02048

AA478422
1301
unc-51 (C. elegans)-like kinase 1
3.83
up
0.00116

AA485060
1339
EST
3.83
up
0.03172

AA101272
215
EST
3.83
up
0.0386

AA425852
958
EST
3.82
up
0.0395

L29218
2190
CDC-like kinase 2
3.82
up
0.00035

AA485431
1345
EST
3.81
up
0.00441

AA233897
476
EST
3.8
up
0.02145

R26744
2803
midline 1 (Opitz/BBB syndrome)
3.8
up
0.00266

AA160775
355
BCL2-antagonist of cell death
3.8
up
0.01145

X54942
3730
CDC28 protein kinase 2
3.8
up
0.0035

T03438
3042
EST
3.79
up
0.02042

AA182001
386
EST
3.78
up
0.04446

N70678
2659
TAR (HIV) RNA-binding protein 1
3.78
up
0.02858

TATA box binding protein (TBP)-associated factor, RNA polymerase II, E,

L25444
2181
70/85 kD
3.78
up
0.00011

AA086071
184
chromosome-associated polypeptide C
3.77
up
0.01993

AA278768
617
EST
3.77
up
0.03239

Z39379
3900
EST
3.77
up
0.00513

J03040
2091
secreted protein, acidic, cysteine-rich (osteonectin)
3.77
up
0.00594

AA449431
1124
translation initiation factor IF2
3.76
up
0.00571

T26471
3093
EST
3.76
up
0.0165

AA262957
612
EST
3.76
up
0.00157

N47956
2523
eukaryotic translation initiation factor 3, subunit 3 (gamma, 40 kD)
3.76
up
0.00968

AA478300
1298
CD39-like 2
3.75
up
0.00152

C14756
1570
MLN51 protein
3.75
up
0.0226

N73705
2676
EST
3.75
up
0.01762

AA046103
109
EST
3.75
up
0.02893

AA076138
167
H2A histone family, member Y
3.75
up
0.01442

AA129757
264
EST
3.75
up
0.0166

H99877
2083
exportin, tRNA (nuclear export receptor for tRNAs)
3.75
up
0.00302

AA488074
1360
cell division cycle 42 (GTP-binding protein, 25 kD)
3.74
up
0.01887

H00540
1829
EST
3.74
up
0.00234

AA173430
371
EST
3.74
up
0.01159

N29742
2480
EST
3.74
up
0.00104

AA402272
837
EST
3.73
up
0.02336

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-

AA404560
853
acetylgluosamine:polypeptide-N-acetylglucosaminyl transferase)
3.73
up
0.0143

N21648
2446
MpV17 transgene, murine homolog, glomerulosclerosis
3.73
up
0.00071

H56345
1950
EST
3.73
up
0.00853

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-

R76782
2962
acetylglucosamine:polypeptide-N-acetylgluosaminyl transferase)
3.73
up
0.00094

J05614
2122
EST
3.73
up
0.03419

AA461476
1243
EST
3.72
up
0.00744

AA255486
568
EST
3.72
up
0.00154

AA423841
942
EST
3.71
up
0.01481

AA491295
1390
calcium/calmodulin-dependent protein kinase kinase 2, beta
3.71
up
0.0103

Z38299
3884
EST
3.71
up
0.0036

AA600153
1460
DEK oncogene (DNA binding)
3.71
up
0.02967

AA609080
1478
EST
3.71
up
0.0306

AA010065
22
CDC28 protein kinase 2
3.71
up
0.00432

D31417
1645
secreted protein of unknown funtion
3.69
up
0.0004

AA018346
38
EST
3.69
up
0.04582

N69252
2646
ferritin, light polypeptide
3.69
up
0.04116

Z23090
3865
heat shock 27 kD protein 1
3.69
up
0.00628

AA402968
844
EST
3.68
up
0.00123

N98464
2743
EST
3.68
up
0.03007

AA165526
360
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1
3.68
up
0.00021

W46286
3523
EST
3.68
up
0.00311

M21259
2293
small nuclear ribonucleoprotein polypeptide E
3.68
up
0.00415

U91930
3459
adaptor-related protein complex 3, delta 1 subunit
3.68
up
0.00009

procollagen-proline. 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha

F09788
1808
polypeptide II
3.67
up
0.01682

AA291137
694
EST
3.67
up
0.03243

H68794
1984
EST
3.67
up
0.00327

N73762
2677
EST
3.67
up
0.00796

R56095
2905
EST
3.67
up
0.0158

R77451
2963
EST
3.67
up
0.00078

N52168
2550
EST
3.66
up
0.00127

AA456852
1199
suppressor of white apricot homolog 2
3.66
up
0.00614

X83425
3809
Lutheran blood group (Auberger b antigen included)
3.66
up
0.02661

H47357
1934
EST
3.65
up
0.03799

AA292788
714
EST
3.65
up
0.01765

siah binding protein 1; FBP interacting repressor; pyrimidine tract binding splicing

U51586
3385
factor; Ro ribonucleoprotein-binding protein 1
3.65
up
0.00403

X56494
3735
pyruvate kinase, muscle
3.65
up
0.04795

F10453
1819
EST
3.64
up
0.01878

T23465
3080
EST
3.64
up
0.00265

Z24727
3868
tropomyosin 1 (alpha)
3.64
up
0.00388

X57809
3743
immunoglobulin lambda locus
3.64
up
0.02655

AA040465
95
EST
3.63
up
0.01806

T16652
3072
BCS1 (yeast homolog)-like
3.63
up
0.00434

AA037766
87
EST
3.63
up
0.0328

AA227541
457
NS1-binding protein
3.6
up
0.02801

AA313213
732
flotillin 1
3.59
up
0.00878

AA251909
549
EST
3.59
up
0.01129

AA487856
1359
KIAA0676 protein
3.59
up
0.01408

M63573
2377
peptidylprolyl isomerase B (cyclophilin B)
3.59
up
0.00916

M94345
2426
capping protein (acetin filament), gelsolin-like
3.59
up
0.04508

AF003521
1545
jagged 2
3.58
up
0.00299

AA489091
1368
EST
3.58
up
0.0002

W49791
3538
plasminogen activator, tissue
3.58
up
0.02438

W90146
3641
EST
3.58
up
0.00322

Z39429
3903
EST
3.58
up
0.00416

X06700
3685
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)
3.58
up
0.02964

W79421
3600
EST
3.57
up
0.00895

X64364
3761
basigin
3.57
up
0.00902

eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange

Z21507
3864
protein)
3.57
up
0.01898

U62392
3402
zinc finger protein 193
3.56
up
0.0407

AA135871
294
EST
3.56
up
0.01718

W72276
3580
EST
3.56
up
0.0476

D63486
1712
KIAA0152 gene product
3.56
up
0.00063

AA258182
589
EST
3.55
up
0.01198

AA179845
381
EST
3.55
up
0.02484

AA599850
1457
EST
3.55
up
0.03215

D13640
1608
KIAA0015 gene product
3.55
up
0.00347

U66661
3405
gamma-aminobutyric acid (GABA) A receptor, epsilon
3.55
up
0.0045

R73569
2959
EST
3.54
up
0.01962

Z40006
3914
EST
3.54
up
0.00156

AA400896
822
EST
3.54
up
0.00889

N98758
2744
EST
3.54
up
0.02609

M27830
2314
EST
3.54
up
0.00777

U90551
3456
H2A histone family, member L
3.54
up
0.01523

M55998
2356
collagen, type I, alpha 1
3.54
up
0.01449

AA485697
1346
EST
3.53
up
0.03566

H07873
1856
EST
3.53
up
0.0391

R06254
2764
tumor protein D52-like 2
3.53
up
0.04865

R27016
2805
myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)
3.53
up
0.03056

U26727
3336
cyclin-dependent kinase inhibtor 2A (melanoma, p16, inhibits CDK4)
3.53
up
0.02913

D81608
1740
polymerase (RNA) II (DNA directed) polypeptide K (7.0 kD)
3.52
up
0.00437

R22565
2799
EST
3.52
up
0.04352

T17353
3076
EST
3.52
up
0.02085

AA409212
1375
H2A histone family, member Y
3.52
up
0.02202

R66469
2936
pleckstrin and Sec7 domain protein
3.52
up
0.0272

AA464722
1263
DKFZP566C243 protein
3.51
up
0.00101

H97012
2058
EST
3.51
up
0.03505

T23426
3078
EST
3.51
up
0.00674

AA399264
805
EST
3.51
up
0.00327

H99774
2081
EST
3.51
up
0.00009

W94281
3655
integral membrane protein 2C
3.51
up
0.01689

X54667
3728
cystatin S,cystatin SN
3.51
up
0.00187

AA278817
618
EST
3.5
up
0.01159

AA489707
1371
EST
3.5
up
0.03208

T59668
3159
lysyl oxidase
3.5
up
0.00083

AA598447
1428
exportin, tRNA (nuclear export receptor for tRNAs)
3.5
up
0.01201

H91632
2031
EST
3.5
up
0.03688

N51771
2547
KIAA0652 gene product
3.5
up
0.00028

R33498
2819
EST
3.5
up
0.03336

AA621409
1524
putative type II membrane protein
3.5
up
0.00462

L04270
2135
lymphotoxin beta receptor (TNFR superfamily, member 3
3.5
up
0.01547

AA243173
526
EST
3.49
up
0.0401

AA442763
1072
cyclin B2
3.49
up
0.04176

AA235868
504
nuclear transcription factor Y, beta
3.49
up
0.01897

T26646
3096
X-ray repair complementing defective repair in Chinese hamster cells 1
3.49
up
0.02482

M34309
2342
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
3.49
up
0.00191

N35913
2502
EST
3.48
up
0.0016

M26576
2310
EST
3.48
up
0.00062

Y08302
3849
dual specificity phosphatase 9
3.48
up
0.00787

Z39191
3898
EST
3.47
up
0.00756

N21407
2442
EST
3.47
up
0.01037

M55210
2353
laminin, gamma 1 (formerly LAMB2)
3.47
up
0.02551

AA236150
507
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1
3.46
up
0.0008

R48473
2871
EST
3.46
up
0.01196

N99944
2748
EST
3.46
up
0.00104

SWI/SNF related, matrix associated, actin dependent regulator of chromatin)

AA598648
1432
subfamily a, member 4
3.46
up
0.00293

C00358
1552
nucleolar protein 3 (apoptosis repressor with CARD domain)
3.45
up
0.00985

AA464251
1257
EST
3.45
up
0.02229

AA598712
1436
EST
3.45
up
0.00005

AA620461
1501
EST
3.45
up
0.01146

R91753
2982
EST
3.45
up
0.02391

Z41349
3928
EST
3.45
up
0.01503

N39237
2510
EST
3.45
up
0.02481

HG4074-HT4344

flap structure-specific endonuclease 1
3.45
up
0.01695

U24704
3331
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
3.45
up
0.00037

X87212
3813
cathepsin C
3.45
up
0.02486

AA094752
203
hypothetical 43.2 Kd protein
3.44
up
0.04445

AA471384
1278
divalent cation tolerant protein CUTA
3.44
up
0.01161

AA443271
1073
KIAA0546 protein
3.44
up
0.00324

R62456
2924
EST
3.44
up
0.00285

R70532
2946
EST
3.44
up
0.02186

T51972
3139
EST
3.44
up
0.00406

AA122386
239
collagen, type V, alpha 2
3.44
up
0.02566

AA496715
1400
spectrin SH3 domain binding protein 1
3.44
up
0.00069

H65042
1975
EST
3.44
up
0.0006

AA024776
48
EST
3.44
up
0.00334

X62153
3751
minichromosome maintenance deficient (S. cerevisiae) 3
3.44
up
0.00704

D30946
1638
kinesin family member 3B
3.43
up
0.01458

AA384184
774
DKFZP586B0519 protein
3.42
up
0.01222

AA461282
1237
dihydropyrimidinase-like 2
3.42
up
0.02014

AA417884
919
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
3.42
up
0.02997

W46947
3530
EST
3.42
up
0.04665

AA479139
1310
acid phosphatase 1, soluble
3.42
up
0.01853

AA412301
899
EST
3.42
up
0.0129

AA116036
233
chromosome 20 open reading frame 1
3.41
up
0.00089

AA370163
766
EST
3.41
up
0.00134

AA598831
1440
EST
3.41
up
0.00452

R31607
2812
EST
3.41
up
0.00163

R27296
2806
EST
3.41
up
0.00309

R52161
2892
EST
3.41
up
0.00053

X66899
3769
Ewing sarcoma breakpoint region 1
3.41
up
0.03777

AA187579
390
MCT-1 protein
3.4
up
0.02455

AA459542
1218
regulatory factor X-associated ankyrin-containing protein
3.4
up
0.00841

AA227145
454
EST
3.4
up
0.03422

AA406216
871
EST
3.4
up
0.00529

AA443316
1075
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
3.4
up
0.00133

H99489
2078
quiescin Q6
3.4
up
0.02682

L11669
2157
tetracycline transporter-like protein
3.4
up
0.02062

excision repair cross-complementing rodent repair deficiency, complementation

L76568
2225
group 4
3.4
up
0.0172

AA424881
949
EST
3.39
up
0.03546

N51855
2549
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3
3.39
up
0.00115

R43952
2852
homeo box B5
3.39
up
0.04829

T23516
3082
3-phosphoglycerate dehydrogenase
3.39
up
0.00551

F10290
1815
EST
3.39
up
0.02392

H62474
1970
EST
3.39
up
0.04173

M57730
2358
ephrin-A1
3.39
up
0.00199

X62534
3752
high-mobility group (nonhistone chromosomal) protein 2
3.39
up
0.0186

Z38444
3888
KIAA0923 protein
3.38
up
0.02918

R70253
2944
EST
3.38
up
0.03125

D28589
1637
EST
3.38
up
0.01144

AA173597
373
EST
3.37
up
0.03622

AA456583
1193
PL6 protein
3.37
up
0.00139

AA621535
1527
FE65-LIKE 2
3.37
up
0.0167

AA029288
65
EST
3.36
up
0.04908

AA207103
429
EST
3.36
up
0.00131

AA286911
684
EST
3.36
up
0.00037

T33625
3107
EST
3.36
up
0.04096

AA052941
121
EST
3.36
up
0.00088

R15740
2790
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
3.36
up
0.00268

T33619
3106
EST
3.36
up
0.01283

M14483
2261
prothymosin, alpha (gene sequence 28)
3.36
up
0.00033

AA488872
1363
EST
3.35
up
0.03191

W80730
3604
EST
3.35
up
0.01526

AA115562
229
EST
3.35
up
0.00283

AA620779
1508
golgin-67
3.35
up
0.00297

C14835
1571
EST
3.35
up
0.0316

AA442155
1068
transforming acidic coiled-coil containing protein 3
3.35
up
0.00344

AA449828
1130
EST
3.35
up
0.01609

transmembrane protein (63 kD), endoplasmic reticulum/Golgi intermediate

X69910
3784
compartment
3.35
up
0.00898

AA421213
931
Lsm3 protein
3.34
up
0.00198

AA456646
1196
EST
3.34
up
0.0309

W84447
3614
EST
3.34
up
0.00986

AA479881
1317
EST
3.34
up
0.03289

D51072
1674
biliverdin reductase A
3.34
up
0.0254

U55206
3391
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
3.34
up
0.00315

X04347
3677
heterogeneous nuclear ribonucleoprotein A1
3.34
up
0.00123

AA451992
1140
HSPC039 protein
3.33
up
0.01696

D82277
1743
LDL induced EC protein
3.33
up
0.00355

AA426521
967
Sjogren's syndrome nuclear autoantigen 1
3.33
up
0.01163

AA128407
259
EST
3.33
up
0.02298

AA046745
113
Wolf-Hirschhorn syndrome candidate 1
3.33
up
0.00648

AA521149
1420
EST
3.33
up
0.00211

AA608668
1465
erythrocyte membrane protein band 4.1-like 2
3.33
up
0.02014

H99261
2074
EST
3.33
up
0.00319

W63608
3561
EST
3.33
up
0.02443

AA456415
1192
KIAA0537 gene product
3.32
up
0.00155

AA479096
1308
EST
3.32
up
0.00118

T97679
3265
EST
3.32
up
0.01566

N48790
2531
EST
3.32
up
0.00654

T81393
3227
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1
3.32
up
0.0023

U73379
3417
ubiquitin carrier protein E2-C
3.32
up
0.00808

AA071387
158
jumping translocation breakpoint
3.31
up
0.0001

AA504413
1413
EST
3.31
up
0.00036

AA429572
1000
ribosomal protein S6
3.31
up
0.02144

R49395
2880
EST
3.31
up
0.00867

R53109
2898
dimethylarginine dimethylaminohydrolase 2
3.31
up
0.02406

AA485084
1340
EST
3.31
up
0.01232

AA136864
304
zinc finger protein homologous to Zfp-36 in mouse
3.31
up
0.00346

D31294
1643
EST
3.3
up
0.004

AA398141
788
EST
3.3
up
0.00211

AA465093
1267
TIA1 cytotoxic granule-associated RNA-binding protein
3.3
up
0.01314

H16251
1886
EST
3.3
up
0.03286

AA620761
1507
EST
3.3
up
0.00285

AA053662
129
EST
3.3
up
0.00558

M27830
2314
EST
3.3
up
0.02453

AF004022
1546
serine/threonine kinase 12
3.29
up
0.00841

AA476944
1288
EST
3.29
up
0.00189

AA452167
1142
EST
3.29
up
0.03337

T17339
3075
EST
3.29
up
0.00669

AA291644
701
EST
3.28
up
0.00033

Z47727
3937
polymerase (RNA) II (DNA directed) polypeptide K (7.0 kD)
3.28
up
0.00317

AA242757
522
EST
3.27
up
0.00286

AA458890
1206
EST
3.27
up
0.00079

R49482
2883
EST
3.27
up
0.0161

W42778
3510
EST
3.27
up
0.02411

AA022623
44
EST
3.27
up
0.01556

AA435662
1039
EST
3.27
up
0.0433

AA284565
675
EST
3.27
up
0.0362

N34825
2497
DKFZP434P106 protein
3.27
up
0.01334

H65030
1974
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
3.26
up
0.02278

Z40883
3921
EST
3.26
up
0.01863

AA621530
1526
EST
3.26
up
0.00298

AA091752
193
purine-rich element binding protein B
3.25
up
0.01419

AA092290
195
EST
3.25
up
0.01616

AA478971
1306
disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein)
3.25
up
0.02698

AA610073
1497
EST
3.25
up
0.00859

AA251230
540
EST
3.25
up
0.01417

N64374
2607
KIAA0537 gene product
3.25
up
0.01652

W69468
3571
EST
3.25
up
0.00055

AA426374
964
tubulin, alpha 2
3.25
up
0.04346

D21063
1628
minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin)
3.25
up
0.03558

AA598589
1431
EST
3.24
up
0.00432

R16144
2793
EST
3.24
up
0.0087

AA195067
414
GTPase activating protein-like
3.24
up
0.00606

W42788
3511
deoxynucleotidyltransferase, terminal
3.24
up
0.02261

U90426
3452
nuclear RNA helicase, DECD variant of DEAD box family
3.24
up
0.00035

AA279418
626
EST
3.23
up
0.02054

F04479
1789
KIAA1067 protein
3.23
up
0.04522

T94452
3256
EST
3.23
up
0.02245

W47206
3532
EST
3.23
up
0.01931

AA074162
159
superkiller viralicidic activity 2 (S. cerevisiae homolog)-like
3.23
up
0.00642

AA406384
875
KIAA0670 protein/acinus
3.23
up
0.00486

L06797
2143
chemokine (C-X-C motif), receptor 4 (fusin)
3.23
up
0.04782

T99312
3269
EST
3.22
up
0.00084

R54614
2901
EST
3.22
up
0.00334

D38305
1652
transducer of ERBB2, 1
3.22
up
0.0215

AA495857
1394
EST
3.21
up
0.02243

W28366
3488
EST
3.21
up
0.01007

AA465342
1271
EST
3.21
up
0.01378

M97856
2435
nuclear autoantigenic sperm protein (histone-binding)
3.21
up
0.00444

T10316
3051
EST
3.2
up
0.04794

AA429470
996
EST
3.2
up
0.0153

AA047704
120
EST
3.2
up
0.0029

AA132514
272
EST
3.2
up
0.00876

X14487
3699
keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)
3.19
up
0.01268

AA167708
363
EST
3.19
up
0.01871

AA431719
1025
EST
3.19
up
0.00294

AA070485
156
interleukin 13 receptor, alpha 1
3.19
up
0.03465

T47969
3127
ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
3.19
up
0.02283

M91083
2418
chromosome 11 open reading frame 13
3.19
up
0.00243

AA476754
1287
EST
3.18
up
0.01696

AA046410
110
EST
3.18
up
0.00797

AA131220
267
EST
3.18
up
0.00974

H73484
1995
ferritin, heavy polypeptide 1
3.18
up
0.00432

M61916
2372
laminin, beta 1
3.18
up
0.01171

AA453628
1154
EST
3.18
up
0.00849

AA465218
1268
DKFZP586M1523 protein
3.17
up
0.00357

N31597
2486
DKFZP564G2022 protein
3.17
up
0.03017

AA021549
42
EST
3.17
up
0.00158

AA025166
50
fusion, derived from t(12;16) malignant liposarcoma
3.17
up
0.00009

AA252524
555
EST
3.17
up
0.00686

W46810
3528
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
3.17
up
0.03434

AA045365
106
EST
3.17
up
0.0149

D57317
1688
activated RNA polymerase II transcription cofactor 4
3.17
up
0.00464

D80710
1734
integral type I protein
3.17
up
0.04549

AA296994
724
seven transmembrane domain protein
3.16
up
0.0076

AA256131
574
glycophosphatidylinositol anchor attachment 1
3.16
up
0.00011

AA282571
662
FSHD region gene 1
3.16
up
0.01355

AA321833
736
EST
3.16
up
0.00523

AA430675
1019
Fanconi anemia, complementation group G
3.16
up
0.01007

AA235853
503
CGI-96 protein
3.16
up
0.00744

N93316
2732
EST
3.16
up
0.01262

R51908
2891
EST
3.16
up
0.0083

AA136474
301
Meis (mouse) homolog 2
3.15
up
0.02837

AA463934
1253
splicing factor 3b, subunit 4, 49 kD
3.15
up
0.00952

W56642
3544
EST
3.15
up
0.00654

AA070206
155
EST
3.15
up
0.03914

AA251428
542
DKFZP586I2223 protein
3.15
up
0.01223

AA253011
558
KIAA0713 protein
3.15
up
0.00035

AA258387
594
EST
3.15
up
0.02028

AA621146
1514
MUF1 protein
3.15
up
0.02116

N69879
2650
drebrin 1
3.15
up
0.01659

AA047379
119
karyopherin (importin) beta 1
3.15
up
0.01572

AA398563
797
EST
3.14
up
0.01895

AA478415
1299
EST
3.14
up
0.0483

U18321
3317
death associated protein 3
3.14
up
0.00833

AA482319
1335
putative type II membrane protein
3.13
up
0.00071

AA086412
187
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16
3.13
up
0.00327

AA256268
576
EST
3.13
up
0.03874

AA450247
1133
EST
3.13
up
0.00531

AA621752
1529
26S proteasome-associated pad1 homolog
3.13
up
0.01571

D20899
1626
EST
3.13
up
0.02128

H89987
2027
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
3.13
up
0.01194

N90238
2711
EST
3.13
up
0.02492

R39610
2837
calpain, large polypeptide L2
3.13
up
0.01863

X14850
3703
H2A histone family, member X
3.13
up
0.01523

Y08999
3852
actin related protein 2/3 complex, subunit 1A (41 kD)
3.13
up
0.02376

HG2994-HT4850

elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)
3.13
up
0.01206

AA446570
1089
EST
3.12
up
0.02228

D13636
1606
general transcription factor IIIC, polypeptide 2 (beta subunit, 110 kD)
3.12
up
0.00022

L34587
2200
transcription elongation factor B (SIII), polypeptide 1 (15 kD, elongin C)
3.12
up
0.00946

S67070
3022
heat shock 27 kD protein 2
3.12
up
0.01688

U59321
3397
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72 kD)
3.12
up
0.02469

AA429825
1003
DKFZP566B023 protein
3.11
up
0.01857

W49743
3537
EST
3.11
up
0.01121

N69084
2642
EST
3.11
up
0.0094

AA236412
511
EST
3.1
up
0.04463

W02695
3466
EST
3.1
up
0.04745

AA285132
682
apoptotic protease activating factor
3.1
up
0.00844

AA621367
1523
EST
3.1
up
0.00066

H48459
1937
KIAA0186 gene product
3.1
up
0.02325

N53067
2556
DKFZP547E1010 protein
3.1
up
0.00101

X92896
3826
DNA segment on chromosome X (unique) 9879 expressed sequence
3.1
up
0.0405

AA005262
13
EST
3.09
up
0.0064

AA430154
1014
EST
3.09
up
0.04401

AA433947
1034
EST
3.09
up
0.00253

AA599808
1455
EST
3.09
up
0.00726

Z38431
3886
EST
3.09
up
0.0083

AA405544
861
EST
3.09
up
0.04146

AA446970
1098
EST
3.09
up
0.01627

D80917
1736
KIAA0670 protein/acinus
3.09
up
0.00168

W72187
3579
EST
3.09
up
0.00134

AA478615
1305
H1 histone family, member X
3.09
up
0.0499

W15495
3473
chromosome 21 open reading frame 5
3.09
up
0.00491

W58247
3548
kinesin family member 4
3.08
up
0.00048

AA428204
987
cofactor required for Sp1 transcriptional activation, subunit 6 (77 kD)
3.08
up
0.00313

AA481060
1326
EST
3.08
up
0.00029

AA481420
1327
EST
3.08
up
0.0206

AA505141
1418
EST
3.08
up
0.02327

T41078
3120
bromodomain adjacent to zinc finger domain, 2B
3.08
up
0.03426

N29484
2477
EST
3.08
up
0.04834

R60512
2917
KIAA0191 protein
3.08
up
0.00856

AA011679
32
EST
3.08
up
0.03649

AA427734
977
cholinergic receptor, nicotinic, epsilon polypeptide
3.08
up
0.04796

D86957
1754
KIAA0202 protein
3.08
up
0.02949

M86667
2410
nucleosome assembly protein 1-like 1
3.08
up
0.00473

AA031814
70
KIAA0958 protein
3.07
up
0.00681

AA236904
518
EST
3.07
up
0.01503

D80946
1737
SFRS protein kinase 1
3.07
up
0.00986

W42674
3509
EST
3.07
up
0.0261

W74536
3595
advanced glycosylation end product-specific receptor
3.07
up
0.00251

AA435681
1041
EST
3.07
up
0.01166

AA599469
1450
EST
3.07
up
0.04154

D13370
1603
APEX nuclease (multifunctional DNA repair enzyme)
3.07
up
0.00857

HG4297-HT4567

activated RNA polymerase II transcription cofactor 4
3.07
up
0.00787

M93036
2421
membrane component, chromosomal 4, surface marker (35 kD glycoprotein)
3.07
up
0.04199

U30825
3342
splicing factor, arginine/serine-rich 9
3.07
up
0.01928

H67964
1981
EST
3.06
up
0.02707

AA194998
413
purinergic receptor (family A group 5)
3.06
up
0.04752

AA435769
1046
EST
3.06
up
0.00615

AA464423
1259
EST
3.06
up
0.01416

AA251766
543
EST
3.06
up
0.0098

AA256524
580
AD022 protein
3.06
up
0.00626

AA412720
905
EST
3.06
up
0.02153

H11320
1875
SUMO-1 activating enzyme subunit 2
3.06
up
0.00167

R28636
2808
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
3.06
up
0.03678

T40439
3114
small nuclear ribonucleoprotein polypeptide B″
3.06
up
0.02842

X79536
3801
heterogeneous nuclear ribonucleoprotein A1
3.06
up
0.00449

H09241
1861
EST
3.05
up
0.01487

AA425544
955
eukaryotic translation initiation factor 2B, subunit 2 (beta, 39 kD)
3.05
up
0.0346

F02863
1782
EST
3.05
up
0.03504

AA477316
1290
calumenin
3.05
up
0.00608

W58081
3547
neuroendocrine-specific protein C like (foocen)
3.05
up
0.03767

AA293868
721
EST
3.04
up
0.0054

AA125808
240
EST
3.04
up
0.02112

AA236532
513
EST
3.04
up
0.03747

Z41747
3933
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
3.04
up
0.01336

AA598829
1439
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
3.04
up
0.00967

Y00764
3848
ubiquinol-cytochrome c reductase hinge protein
3.04
up
0.01294

N42272
2514
EST
3.03
up
0.0017

AA284720
676
EST
3.03
up
0.00252

R46079
2867
EST
3.03
up
0.00755

H96850
2055
dolichyl-diphosphooligosaccharide-protein glycosyltransferase
3.03
up
0.00679

AA426291
961
EST
3.03
up
0.00365

H99364
2075
chloride channel 7
3.03
up
0.01727

R06400
2767
EST
3.03
up
0.03266

R20817
2796
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
3.03
up
0.01091

D86977
1757
KIAA0224 gene product
3.03
up
0.00053

AA442400
1071
hepatitis B virus x-interacting protein (9.6 kD)
3.02
up
0.04037

AA055892
134
EST
3.02
up
0.04984

W04507
3468
prefoldin 4
3.02
up
0.04091

Z38904
3893
EST
3.02
up
0.00814

AA252355
553
EST
3.02
up
0.00715

AA293589
719
zinc finger protein
3.02
up
0.01809

AA453656
1155
EST
3.02
up
0.00958

U68142
3410
RAB2, member RAS oncogene family-like
3.02
up
0.0296

U90904
3457
EST
3.02
up
0.00381

J04029
2102
keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)
3.02
up
0.00032

AA598749
1438
EST
3.01
up
0.03714

F10741
1822
KIAA0622 protein
3.01
up
0.03079

AA365708
764
microfibrillar-associated protein 1
3.01
up
0.02372

AA426447
965
EST
3.01
up
0.02414

W57931
3546
EST
3.01
up
0.02661

AA181580
383
karyopherin (importin) beta 1
3.01
up
0.0125

H27897
1911
hypothetical protein
3.01
up
0.00174

N51590
2545
EST
3.01
up
0.04345

R46337
2868
secretory carrier membrane protein 3
3.01
up
0.00374

T66935
3178
EST
3.01
up
0.00123

AA173505
372
EST
3
up
0.01736

AA476473
1285
EST
3
up
0.01324

AA448252
1114
EST
3
up
0.00256

W95841
3663
EST
3
up
0.00466

[0135]

11

TABLE 7B

Down in HCC 2 vs Normal Sample Set 2

Fragment

Fold

Name
SEQ ID:
Known Gene Name
Change
Direction
Pvalue

H81070
2006
RNA helicase-related protein
39.64
down
0.00002

AA007395
17
alcohol dehydrogenase 4 (class II), pi polypeptide
37.78
down
0.00939

T68711
3187
EST
35.98
down
0.0003

T48075
3129
hemoglobin, alpha 1
35.75
down
0.00471

N80129
2702
metallothionein 1L
26.87
down
0.00999

AA010605
26
4-hydroxyphenylpyruvate dioxygenase
25.52
down
0.00855

W88946
3636
putative glycine-N-acyltransferase
25.28
down
0.00221

T48278
3131
EST
24.1
down
0.00595

T95813
3261
KIAA1051 protein
20.36
down
0.01361

H58692
1960
formyltetrahydrofolate dehydrogenase
20.18
down
0.00485

cytochrome P450, subfamily VIIIB

(sterol 12-alpha-hydroxylase),

R97419
3003
polypeptide 1
19.3
down
0.00807

H80901
2005
ficolin (collagen/fibrinogen domain-containing)
18.59
down
0

3 (Hakata antigen)

J03910
2101
EST
18.13
down
0.00119

M29873
2318
cytochrome P450, subfamily IIB
17.92
down
0.01469

(phenobarbital-inducible)

U56814
3392
deoxyribonuclease I-like 3
17.69
down
0.00007

T67931
3183
fibrinogen, B beta polypeptide
17.25
down
0.00128

T58756
3155
EST
16.61
down
0

R49602
2884
EST
16.17
down
0.00279

T69305
3196
EST
15.87
down
0.02258

Z20777
3863
EST
15.73
down
0.00147

H58673
1959
EST
15.49
down
0.00002

T56281
3150
RNA helicase-related protein
14.64
down
0.00027

K03192
2127
cytochrome P450, subfamily IIA
14.19
down
0.0307

(phenobarbital-inducible), polypeptide 6

AA448002
1113
putative type II membrane protein
14.14
down
0

T68873
3189
metallothionein 1L
13.68
down
0.00593

R89811
2979
HGF activator
13.29
down
0.00148

M14777
2263
glutathione S-transferase A2, glutathione
13.23
down
0.03224

S-transferase A3

D31628
1646
4-hydroxyphenylpyruvate dioxygenase
13.18
down
0.02064

H20543
1897
DKFZP586B1621 protein
13.06
down
0.00218

W81552
3612
EST
12.97
down
0.00244

N54053
2560
secreted phosphoprotein 2, 24 kD
12.87
down
0.01821

R40395
2840
lecithin-cholesterol acyltransferase
12.85
down
0.01334

H08102
1858
breast cell glutaminase
12.85
down
0.0424

AA455988
1184
butyrobetaine (gamma), 2-oxoglutarate
12.51
down
0

dioxygenase (gamma-butyrobetaine hydroxylase)

R12472
2788
EST
12.09
down
0.02379

U22029
3326
cytochrome P450, subfamily IIA
11.85
down
0.03538

(phenobarbital-inducible), polypeptide 7

AA446864
1095
EST
11.57
down
0.0001

N80129
2702
metallothionein 1L
11.48
down
0.00167

M33317
2338
cytochrome P450, subfamily IIA (phenobarbital-
11.47
down
0.02611

inducible), polypeptide 7 fatty-acid-Coenzyme

A ligase, long-chain 1, fatty-acid-Coenzyme A ligase,

AA348922
758
long-chain 2
11.4
down
0.00848

T98676
3268
EST
11.15
down
0.0323

M81349
2404
serum amyloid A4, constitutive
10.97
down
0.01946

AA074885
161
macrophage receptor with collagenous structure
10.88
down
0.00087

M16974
2277
complement component 8, alpha polypeptide
10.85
down
0.02313

N70966
2662
solute carrier family 10 (sodium/bile acid
10.8
down
0.02894

cotransporter family), member 1

AA279676
630
deoxyribonuclease I-like 3
10.52
down
0.00181

N68596
2635
betaine-homocysteine methyltransferase
10.46
down
0.01971

AA433946
1033
EST
10.24
down
0.00663

W72382
3581
oxidative 3 alpha hydroxysteroid dehydrogenase;
9.89
down
0.03091

retinol dehydrogenase

X56411
3734
alcohol dehydrogenase 4 (class II), pi polypeptide
9.87
down
0.01416

D00003
1586
cytochrome P450, subfamily IIIA (niphedipine oxidase),
9.46
down
0.00001

polypeptide 3

AA448300
1116
FXYD domain-containing ion transport regulator 1
9.27
down
0.00108

(phospholemman)

H77597
2000
metallothionein 1H
9.01
down
0.00022

HG1428-HT1428

hemoglobin, beta
8.98
down
0.02071

R08564
2779
plasminogen-like
8.77
down
0.01284

T51150
3136
EST
8.65
down
0.00553

H93381
2036
EST
8.62
down
0.01271

N58009
2577
formiminotransferase cyclodeaminase
8.52
down
0.01808

AA417046
915
fatty-acid-Coenzyme A ligase, very long-chain 1
8.49
down
0.02476

T57140
3151
paraoxonase 3
8.47
down
0.01048

N70358
2656
growth hormone receptor
8.47
down
0.00816

AA256367
579
paraoxonase 3
8.37
down
0.02326

R98073
3008
EST
8.37
down
0.01436

N74025
2684
deiodinase, iodothyronine, type I
8.18
down
0.01363

N51117
2543
EST
8.17
down
0.00105

M29874
2319
cytochrome P450, subfamily IIB
8.13
down
0.01064

(phenobarbital-inducible)

L04751
2138
cytochrome P450, subfamily IVA, polypeptide 11
8.13
down
0.02065

X13930
3697
cytochrome P450, subfamily IIA
8.1
down
0.0219

(phenobarbital-inducible), polypeptide 6

U50929
3379
betaine-homocysteine methyltransferase
8.04
down
0.0188

Z28339
3872
aldo-keto reductase family 1, member D1
8.03
down
0.00853

(delta 4-3-ketosteroid-5-beta-reductase)

T83397
3232
phytanoyl-CoA hydroxylase (Refsum disease)
8.03
down
0.02173

K03192
2127
cytochrome P450, subfamily IIA
8.02
down
0.03483

(phenobarbital-inducible), polypeptide 6

AA401562
830
EST
7.97
down
0.00527

AA035245
79
aldehyde oxidase 1
7.79
down
0.02387

M94065
2424
dihydroorotate dehydrogenase
7.87
down
0.0011

AA453988
1160
methionine adenosyltransferase I, alpha
7.78
down
0.02695

X54380
3727
pregnancy-zone protein
7.71
down
0.00069

H57060
1954
EST
7.57
down
0.00875

R99591
3015
CD5 antigen-like (scavenger receptor cysteine
7.41
down
0.00043

rich family)

Z84721
3950
hemoglobin, zeta
7.39
down
0.01921

D14012
1612
HGF activator
7.27
down
0.00145

Z49269
3942
small inducible cytokine subfamily A (Cys-Cys),
7.24
down
0.01047

member 14

T74542
3214
UDP glycosyltransferase 2 family, polypeptide B10
7.19
down
0.011

AA235310
496
EST
7.08
down
0.04056

R73816
2960
EST
7.05
down
0.01287

AA287566
690
KIAA0187 gene product
6.99
down
0.00023

N51773
2548
EST
6.92
down
0.01839

W28944
3493
EST
6.9
down
0.01014

N54429
2567
EST
6.85
down
0.03334

N63845
2604
phytanoyl-CoA hydroxylase (Refsum disease)
6.82
down
0.00369

D00003
1586
cytochrome P450, subfamily IIIA
6.8
down
0.01328

(niphedipine oxidase), polypeptide 3

AA236455
512
EST
6.73
down
0.02418

K02402
2125
coagulation factor IX (plasma thromboplastic
6.64
down
0.04082

component, Christmas disease, hemophilia B)

H59136
1962
EST
6.63
down
0.00033

AA057678
143
EST
6.63
down
0.00089

X16349
3709
sex hormone-binding globulin
6.61
down
0.00008

R65593
2934
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
6.6
down
0.01982

AA099225
206
EST
6.59
down
0.00064

N54950
2572
ketohexokinase (fructokinase)
6.47
down
0.0223

N54417
2566
fibrinogen, A alpha polypeptide
6.47
down
0.00733

R92475
2986
flavin containing monooxygenase 3
6.46
down
0.02269

R69417
2941
EST
6.43
down
0.00778

R40492
2841
EST
6.4
down
0.00527

U06641
3286
UDP glycosyltransferase 2 family, polypeptide B15
6.37
down
0.01594

AA599937
1458
insulin-like growth factor-binding protein 4
6.31
down
0.0477

T63364
3169
ficolin (collagen/fibrinogen domain-containing) 3
6.27
down
0.00455

(Hakata antigen)

AA490620
1378
EST
6.25
down
0.03613

R59722
2915
EST
6.24
down
0.02361

M10943
2234
metallothionein 1F (functional)
6.23
down
0.00007

X95190
3829
acyl-Coenzyme A oxidase 2, branched chain
6.22
down
0.00162

AA232114
463
epoxide hydrolase 2, cytoplasmic
6.18
down
0.00231

J02843
2088
cytochrome P450, subfamily IIE (ethanol-inducible)
6.18
down
0.01308

AA150776
330
EST
6.17
down
0.00004

T51617
3137
solute carrier family 22
6.16
down
0.04198

(extraneuronal monoamine transporter), member 3

N64036
2606
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme
6.12
down
0.00476

A dehydrogenase

T74608
3215
hydroxyacid oxidase (glycolate oxidase) 1
6.1
down
0.00249

M76665
2397
hydroxysteroid (11-beta) dehydrogenase 1
6.06
down
0.01317

L12760
2162
phosphoenolpyruvate carboxykinase 1 (soluble)
6.06
down
0.01005

W86075
3621
EST
6.04
down
0.01486

D12620
1601
cytochrome P450, subfamily IVF, polypeptide 2,
6.03
down
0.03947

cytochrome P450, subfamily IVE, polypeptide 3

(leukotriene B4 omega hydroxylase)

M83652
2407
properdin P factor, complement
6
down
0.00002

D62518
1708
EST
5.96
down
0.00027

L16883
2166
cytochrome P450, subfamily IIC
5.85
down
0.04368

(mephenytoin 4-hydroxylase), polypeptide 9

AA233152
467
EST
5.8
down
0.00272

AA343142
751
EST
5.79
down
0.02747

U56814
3392
deoxyribonuclease I-like 3
5.75
down
0.00152

T78433
3219
glycogen synthase 2 (liver)
5.74
down
0.00949

AA454733
1169
EST
5.73
down
0.00748

AA010205
23
EST
5.71
down
0.00014

AA284795
678
phosphatidylethanolamine N-methyltransferase
5.7
down
0.00004

N31741
2488
serine hydroxymethyltransferase 1 (soluble)
5.66
down
0.00212

X76717
3794
metallothionein 1L
5.64
down
0.00215

W55903
3543
adipose differentiation-related protein; adipophilin
5.64
down
0.00014

AA253369
563
EST
5.64
down
0.00478

D13243
1602
pyruvate kinase, liver and RBC
5.58
down
0.04029

AA007629
19
EST
5.56
down
0.00005

R93776
2992
EST
5.55
down
0.00084

D78011
1717
dihydropyrimidinase
5.54
down
0.0312

AA005358
14
EST
5.51
down
0.00059

R77628
2965
insulin induced gene 1
5.51
down
0.0404

W87532
3631
putative glycine-N-acyltransferase
5.5
down
0.00739

AA460661
1229
EST
5.46
down
0.00151

M16594
2272
glutathione S-transferase A2
5.42
down
0.03813

T52813
3141
putative lymphocyte G0/G1 switch gene
5.4
down
0.02021

L32140
2192
afamin
5.39
down
0.02767

AA039335
89
coagulation factor XII (Hageman factor)
5.33
down
0.03807

U20530
3321
secreted phosphoprotein 2, 24 kD
5.31
down
0.01119

AA236401
510
EST
5.31
down
0.01787

AA478298
1297
adipose specific 2
5.29
down
0.00943

AA010619
27
EST
5.28
down
0.002

AA609519
1482
EST
5.23
down
0.00068

L21893
2176
solute carrier family 10
5.23
down
0.03367

(sodium/bile acid cotransporter family), member 1

AA287122
686
EST
5.21
down
0.00523

AA608837
1472
EST
5.15
down
0.00005

M83772
2408
flavin containing monooxygenase 3
5.14
down
0.02023

S70004
3028
glycogen synthase 2 (liver)
5.13
down
0.00183

AA172372
370
EST
5.12
down
0.00032

AA090439
192
ribosomal protein S6
5.11
down
0.01108

AA236455
512
EST
5.1
down
0.00307

J04449
2110
cytochrome P450, subfamily IIIA
5.07
down
0.01733

(niphedipine oxidase), polypeptide 3

AA291749
703
estrogen receptor 1
5.06
down
0.00044

S68287
3024
aldo-keto reductase family 1, member C4
5.04
down
0.02895

(chlordecone reductase; 3-alpha hydroxysteroid

dehydrogenase, type I; dihydrodiol dehydrogenase 4)

AA458652
1202
EST
5.03
down
0.00065

K02766
2126
complement component 9
5.03
down
0.0433

AA297532
725
EST
5.01
down
0.00745

H29568
1914
EST
5
down
0.00426

AA285053
681
EST
5
down
0.00718

Z40902
3923
SEC14 (S. cerevisiae)-like 2
4.97
down
0.04672

T72906
3209
EST
4.91
down
0.00512

N22938
2452
serum amyloid A4, constitutive
4.91
down
0.01918

R79750
2970
EST
4.89
down
0.00695

AA609537
1483
hepatic leukemia factor
4.88
down
0.00118

N57464
2575
CCAAT/enhancer binding protein (C/EBP), delta
4.87
down
0.00111

AA196287
420
EST
4.86
down
0.01656

J05428
2120
UDP glycosyltransferase 2 family, polypeptide B7
4.86
down
0.03414

D49357
1665
methionine adenosyltransferase I, alpha
4.85
down
0.04435

R40899
2843
glycine receptor, beta
4.84
down
0.02369

AA480991
1323
EST
4.83
down
0.03498

M99439
2437
transducin-like enhancer of split 4, homolog of
4.82
down
0.00121

Drosophila E(sp1)

X06562
3683
growth hormone receptor
4.8
down
0.00507

AA426640
969
small inducible cytokine subfamily B (Cys-X-Cys),
4.8
down
0.00539

member 14 (BRAK)

AA194997
412
EST
4.8
down
0.00153

N39201
2509
protease inhibitor 4 (kallistatin)
4.79
down
0.02015

T16484
3070
EST
4.78
down
0.00009

N59550
2587
EST
4.78
down
0.02924

AA046747
114
EST
4.77
down
0.00023

T72502
3207
EST
4.74
down
0.00404

AA085987
183
UDP glycosyltransferase 1
4.74
down
0.03035

D12620
1601
cytochrome P450, subfamily IVF, polypeptide 2,
4.7
down
0.04091

cytochrome P450, subfamily IVF, polypeptide 3

(leukotriene B4 omega hydroxylase)

U51010
3380
nicotinamide N-methyltransferase
4.69
down
0.03099

N67105
2623
EST
4.69
down
0.00194

R93714
2991
fetuin B
4.65
down
0.03704

AA076383
171
EST
4.65
down
0.00593

N73543
2674
EST
4.64
down
0.03981

Y00317
3842
UDP glycosyltransferase 2 family, polypeptide B4
4.63
down
0.02986

U95090
3463
nephrosis 1, congenital, Finnish type (nephrin)
4.63
down
0.01595

T40936
3117
EST
4.62
down
0.02844

AA477119
1289
EST
4.62
down
0.00072

HG2841-HT2968

albumin
4.62
down
0.00552

AA377087
771
EST
4.61
down
0.01616

Z48475
3940
glucokinase (hexokinase 4) regulatory protein
4.6
down
0.01693

R94674
2995
EST
4.58
down
0.0047

N52322
2552
EST
4.58
down
0.02077

AA621131
1513
EST
4.57
down
0.03867

R01023
2751
glucokinase (hexokinase 4) regulatory protein
4.56
down
0.04036

L09229
2150
fatty-acid-Coenzyme A ligase, long-chain 1,
4.5
down
0.01347

fatty-acid-Coenzyme A ligase, long-chain 2

N29764
2481
EST
4.48
down
0.013

Z40259
3916
EST
4.47
down
0.00093

M31667
2331
cytochrome P450, subfamily I
4.47
down
0.01116

(aromatic compound-inducible), polypeptide 2

W26996
3483
EST
4.46
down
0.00734

U02388
3277
cytochrome P450, subfamily IVF, polypeptide 2
4.4
down
0.00761

W67147
3565
deleted in liver cancer 1
4.37
down
0.00069

H55759
1949
EST
4.36
down
0.0398

AA112101
222
EST
4.36
down
0.03175

D79276
1722
succinate-CoA ligase, GDP-forming, beta subunit
4.34
down
0.00836

R66002
2935
EST
4.33
down
0.00789

N66066
2612
EST
4.33
down
0.0184

AA398892
800
similar to yeast BET3 (S. cerevisiae)
4.33
down
0.01326

C20653
1578
EST
4.32
down
0.00718

R22905
2800
EST
4.31
down
0.01744

M25079
2305
hemoglobin, beta
4.31
down
0.01567

N39163
2508
metallothionein 1L
4.3
down
0.03917

M26393
2309
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain
4.3
down
0.02294

H02855
1832
EST
4.29
down
0.0138

X90579
3816
EST
4.26
down
0.04759

X63359
3756
UDP glycosyltransferase 2 family, polypeptide B10
4.26
down
0.01725

X72177
3787
complement component 6
4.25
down
0.01598

W95041
3659
EST
4.22
down
0.01005

AA223902
450
EST
4.22
down
0.01315

AA435746
1043
GTPase activating protein-like
4.21
down
0.03192

T68878
3190
carboxylesterase 1 (monocyte/macrophage serine
4.18
down
0.02474

esterase 1)

AA100026
211
EST
4.18
down
0.00567

L27050
2186
apolipoprotein F
4.18
down
0.04901

D10040
1593
fatty-acid-Coenzyme A ligase, long-chain 2
4.15
down
0.02947

AA253216
561
EST
4.14
down
0.0014

H93246
2035
EST
4.14
down
0.00058

AA258350
592
EST
4.1
down
0.02962

X58022
3744
corticotropin releasing hormone-binding protein
4.09
down
0.00076

Z40305
3917
EST
4.09
down
0.00096

AA599814
1456
EST
4.09
down
0.00235

AA428325
988
EST
4.09
down
0.02486

T61649
3164
superoxide dismutase 2, mitochondrial
4.08
down
0.0389

D11756
1596
EST
4.08
down
0.02972

N77326
2695
EST
4.08
down
0.00768

X67491
3773
glutamate dehydrogenase 1
4.06
down
0.00273

W28414
3489
EST
4.06
down
0.00083

T98199
3266
EST
4.05
down
0.00753

M10942
2233
metallothionein 1E (functional)
4.05
down
0.01412

H06935
1855
electron-transferring-flavoprotein dehydrogenase
4.04
down
0.01498

AA129390
262
EST
4.03
down
0.00128

W87781
3633
EST
4.02
down
0.00284

AA621209
1516
similar to Caenorhabditis elegans protein C42C1.9
4.01
down
0.00563

L05144
2139
phosphoenolpyruvate carboxykinase 1 (soluble)
4
down
0.021

N34804
2496
DKFZP434J214 protein
3.97
down
0.0175

U08006
3289
complement component 8, alpha polypeptide
3.96
down
0.04272

Z69923
3945
HGF activator
3.95
down
0.00012

H87765
2017
KIAA0626 gene product
3.94
down
0.00123

R43799
2850
EST
3.93
down
0.005

C02460
1562
EST
3.92
down
0.03073

H99727
2080
adipose differentiation-related protein; adipophilin
3.91
down
0.00325

AA486511
1349
EST
3.9
down
0.01409

AA477919
1293
EST
3.9
down
0.00265

M63967
2378
aldehyde dehydrogenase 5
3.88
down
0.00274

W44745
3517
EST
3.87
down
0.01051

N63391
2599
EST
3.87
down
0.02935

L00389
2132
cytochrome P450, subfamily I
3.87
down
0.00844

(aromatic compound-inducible), polypeptide 2

W63728
3562
EST
3.86
down
0.00288

AA435985
1049
EST
3.86
down
0.01713

AA151676
337
peptidyl arginine deiminase, type II
3.85
down
0.00875

AA076326
170
SEC14 (S. cerevisiae)-like 2
3.85
down
0.0349

X02176
3669
complement component 9
3.84
down
0.01793

AA039616
90
EST
3.84
down
0.00997

HG2730-HT2827

fibrinogen, A alpha polypeptide
3.84
down
0.00795

H66367
1977
EST
3.84
down
0.00133

M30185
2321
cholesteryl ester transfer protein, plasma
3.82
down
0.00131

AA167565
362
EST
3.81
down
0.04057

HG2379-HT3996

serine hydroxymethyltransferase 1 (soluble)
3.81
down
0.01837

D90042
1767
N-acetyltransferase 2
3.79
down
0.00697

(arylamine N-acetyltransferase)

X16260
3707
inter-alpha (globulin) inhibitor, H1 polypeptide
3.76
down
0.00291

AA122345
238
glutamate dehydrogenase 1
3.75
down
0.01058

M86826
2412
insulin-like growth factor binding protein,
3.75
down
0.01157

acid labile subunit

L11931
2159
serine hydroxymethyltransferase 1 (soluble)
3.74
down
0.0056

AA460012
1224
solute carrier family 22
3.73
down
0.0313

(extraneuronal monoamine transporter), member 3

X97324
3836
adipose differentiation-related protein; adipophilin
3.72
down
0.00202

D63160
1709
ficolin (collagen/fibrinogen domain-containing
3.72
down
0.00312

lectin) 2 (hucolin)

W86600
3625
EST
3.67
down
0.04208

N52271
2551
LIM protein (similar to rat protein kinase C-binding
3.67
down
0.01102

enigma)

AA402224
836
growth arrest and DNA-damage-inducible, gamma
3.66
down
0.0033

N91087
2716
EST
3.66
down
0.00725

C02386
1561
hypothetical protein
3.66
down
0.00673

U27699
3339
solute carrier family 6 (neurotransmitter
3.65
down
0.00381

transporter, betaine/GABA), member 12

U08021
3290
nicotinamide N-methyltransferase
3.63
down
0.03762

HG2730-HT2828

fibrinogen, A alpha polypeptide
3.62
down
0.01013

R80048
2971
EST
3.61
down
0.01209

M94065
2424
dihydroorotate dehydrogenase
3.61
down
0.00229

J03810
2099
solute carrier family 2 (facilitated glucose
3.6
down
0.02376

transporter), member 2

D00408
1589
cytochrome P450,
3.58
down
0.02048

subfamily IIIA (niphedipine oxidase), polypeptide

3, cytochrome P450, subfamily IIIA

(niphedipine oxidase), polypeptide 5, cytochrome

P450, subfamily IIIA, polypeptide 7

C20810
1579
EST
3.57
down
0.02116

T61256
3161
ketohexokinase (fructokinase)
3.56
down
0.04957

AA164586
359
estrogen receptor 1
3.56
down
0.01231

S77356
3033
EST
3.55
down
0.03874

X14813
3702
acetyl-Coenzyme A acyltransferase 1
3.53
down
0.00059

(peroxisomal 3-oxoacyl-Coenzyme A thiolase)

AA460449
1228
EST
3.53
down
0.01247

N99542
2746
orosomucoid 1
3.53
down
0.00607

W07723
3470
EST
3.51
down
0.00026

F02245
1776
monoamine oxidase A
3.51
down
0.01692

AA182030
387
EST
3.51
down
0.0403

W45560
3522
EST
3.48
down
0.0179

W73818
3590
EST
3.47
down
0.00927

AA455367
1176
DKFZP586F1018 protein
3.47
down
0.00138

T87174
3239
EST
3.46
down
0.00026

AA282061
652
KIAA0962 protein
3.46
down
0.00698

AA233837
474
EST
3.46
down
0.01365

W73601
3589
EST
3.45
down
0.01382

R09053
2782
EST
3.45
down
0.03074

AA142849
306
EST
3.45
down
0.03495

M61854
2370
cytochrome P450, subfamily IIC
3.45
down
0.02949

(mephenytoin 4-hydroxylase)

AA376875
770
monoamine oxidase A
3.45
down
0.00105

N29353
2476
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
3.44
down
0.01212

N22404
2449
EST
3.44
down
0.02267

AA608802
1470
EST
3.44
down
0.01709

T40995
3118
alcohol dehydrogenase 3 (class I), gamma polypeptide
3.42
down
0.00957

AA035457
80
EST
3.41
down
0.00968

AA401376
829
EST
3.39
down
0.01403

AA018922
40
core promoter element binding protein
3.39
down
0.01801

N65959
2611
EST
3.38
down
0.00785

AA188921
393
similar to Caenorhabditis elegans protein C42C1.9
3.38
down
0.00862

Z41042
3925
EST
3.37
down
0.00703

H27330
1909
EST
3.37
down
0.01318

AA450127
1132
growth arrest and DNA-damage-inducible, beta
3.37
down
0.00647

J05158
2117
carboxypeptidase N, polypeptide 2, 83 kD
3.37
down
0.01156

N90584
2713
EST
3.36
down
0.01561

F03969
1785
matrix metalloproteinase 2 (gelatinase A,
3.36
down
0.01685

72 kD gelatinase, 72 kD type IV collagenase)

M95585
2429
hepatic leukemia factor
3.36
down
0.00492

HG4533-HT4938

protease inhibitor 4 (kallistatin)
3.35
down
0.01605

X06985
3686
heme oxygenase (decycling) 1
3.34
down
0.00045

H66840
1978
EST
3.34
down
0.01884

M72885
2392
putative lymphocyte G0/G1 switch gene
3.34
down
0.02943

W28798
3491
phosphodiesterase 6A, cGMP-specific, rod, alpha
3.33
down
0.00222

T47778
3126
fibrinogen, A alpha polypeptide
3.33
down
0.00637

AA599472
1451
succinate-CoA ligase, GDP-forming, beta subunit
3.31
down
0.02619

AA084668
180
ubiquitin-like 3
3.31
down
0.02055

M30185
2321
cholesteryl ester transfer protein, plasma
3.31
down
0.00109

L00352
2131
low density lipoprotein receptor
3.3
down
0.03487

(familial hypercholesterolemia)

D13705
1610
cytochrome P450, subfamily IVA, polypeptide 11
3.3
down
0.0051

Z31690
3878
lipase A, lysosomal acid, cholesterol esterase
3.29
down
0.00161

(Wolman disease)

AA450114
1131
EST
3.29
down
0.01171

AA282886
663
EST
3.29
down
0.00025

AA397841
780
EST
3.29
down
0.00825

N57934
2576
formiminotransferase cyclodeaminase
3.28
down
0.01555

J04093
2106
UDP glycosyltransferase 1
3.28
down
0.02286

X64177
3760
metallothionein 1H
3.26
down
0.03928

T10264
3050
EST
3.26
down
0.01718

C21130
1583
EST
3.24
down
0.03355

AA070191
154
EST
3.24
down
0.00216

H62212
1969
telomeric repeat binding factor 2
3.23
down
0.00513

X13227
3695
D-amino-acid oxidase
3.22
down
0.01753

Z80345
3948
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain
3.21
down
0.04734

M68895

alcohol dehydrogenase 6 (class V)
3.21
down
0.02095

AA400177
808
EST
3.21
down
0.03901

H09317
1864
EST
3.2
down
0.00914

T68510
3186
EST
3.19
down
0.01504

AA465233
1269
succinate-CoA ligase, GDP-forming, beta subunit
3.19
down
0.00036

AA461444
1239
EST
3.19
down
0.02844

AA147646
317
DKFZP586A0522 protein
3.19
down
0.00508

D78725
1720
KIAA0914 gene product
3.19
down
0.01083

U65932
3404
extracellular matrix protein 1
3.18
down
0.00575

U21931
3325
fructose-bisphosphatase 1
3.17
down
0.0143

T64575
3171
EST
3.16
down
0.01855

M57731
2359
GRO2 oncogene
3.16
down
0.02204

F02028
1774
EST
3.15
down
0.00902

T41232
3121
EST
3.14
down
0.02012

AA210850
431
EST
3.12
down
0.00288

W72044
3577
insulin induced gene 1
3.1
down
0.03445

M68840
2388
monoamine oxidase A
3.1
down
0.01953

H57816
1957
EST
3.09
down
0.01327

H10779
1872
methylenetetrahydrofolate dehydrogenase
3.09
down
0.0496

(NADP + dependent).

methenyltetrahydrofolate cyclohydrolase,

formyltetrahydrofolate synthetase

M93405
2423
methylmalonate-semialdehyde dehydrogenase
3.09
down
0.03285

T41047
3119
EST
3.08
down
0.00553

AA157799
348
aldo-keto reductase family 7, member A2
3.08
down
0.00207

(aflatoxin aldehyde reductase)

M34276
2341
plasminogen
3.08
down
0.02754

H05704
1848
EST
3.07
down
0.00363

AA069696
150
EST
3.07
down
0.01569

M16750
2273
pim-1 oncogene
3.07
down
0.02391

AA056482
141
EST
3.06
down
0.01313

AA046457
111
EST
3.05
down
0.02078

M13143
2249
kallikrein B plasma, (Fletcher factor) 1
3.04
down
0.008

U50196
3376
adenosine kinase
3.03
down
0.00975

AA090257
190
superoxide dismutase 2, mitochondrial
3.03
down
0.02774

N49902
2539
EST
3.02
down
0.00951

AA442334
1069
EST
3.02
down
0.01936

D45529
1662
EST
3.01
down
0.03105

AA404487
851
EST
3.01
down
0.0059

[0136]

12

TABLE 8A

Genes and ESTs expressed only in HCC2 vs Normal2

hcc sample
hcc sample

fold change

hcc sample
set 2:
set 2: Std
normal set

Fragment Name
SEQ ID:
Known Gene Name
in hcc set 2
p value
set 2: Mean
Median
Dev
2: Mean
normal set 2: Median
normal set 2: Std Dev

AA093497
199
DEK oncogene (DNA binding)
#N/A
#N/A
180.58
107.64
165.71
52.11
48.84
26.51

AA248283
534
EST
#N/A
#N/A
67.18
45.86
55.18
21.63
18.96
11.71

AA291456
700
EST
#N/A
#N/A
828.34
830.24
196.63
671.21
509.58
629.13

AA400643
817
GAS2-related on chromosome 22
4.04
0.03751
118.72
123.18
137.15
−43.6
−33.96
60.39

AA421079
930
EST
#N/A
#N/A
37.17
34.26
18.5
15.27
16.75
15.28

AA428172
986
Notch (Drosophila) homolog 3
9.63
0.00195
335.57
374.9
231.52
−9.64
−15.61
56.16

AA464043
1255
EST
3.99
0.00056
116.97
115.99
53.49
14.27
10.06
25.86

H19562
1896
PTD010 protein
#N/A
#N/A
522.13
432.65
256.94
393.61
326.53
182.71

L08044
2149
trefoil factor 3 (intestinal)
#N/A
#N/A
214.6
108.17
238.79
107.82
58.55
184.16

L29218
2190
CDC-like kinase 2
6.51
0.00019
219.64
237.35
104.29
6.53
−10.03
59.8

L37747
2206
lamin B1
#N/A
#N/A
43.42
28.65
37.33
5.97
5.1
7.57

N34257
2494
EST
#N/A
#N/A
20.76
21.48
19.54
−1.84
−2.74
8.53

R50692
2887
KIAA0476 gene product
#N/A
#N/A
197.89
187.87
101.08
148.53
151.12
63.03

R60368
2916
EST
#N/A
#N/A
29.68
28.93
31.9
−28.29
−26.44
41.68

R66475
2937
EST
#N/A
#N/A
45.68
32.34
34.37
7.64
8.26
6.3

potassium voltage-gated channel, shaker-

T34377
3110
related subfamily, beta member 2
4.55
0.00041
113.59
120.58
51.65
6.87
11.17
25.69

DEAD/H (Asp-Glu-Ala-Asp/His) box

polypeptide 11 (S.cerevisiae CHL1-like

U75968
3422
helicase)
#N/A
#N/A
187.33
200.16
90.35
115.5
102.24
77.72

W21426
3480
KIAA0806 gene product
#N/A
#N/A
63.36
64.93
20.23
45.59
40.39
19.89

W28696
3490
EST
#N/A
#N/A
14.7
20.64
17.12
4.28
4.33
2.47

X57129
3740
H1 histone family, member 2
4.63
0.00663
137.13
137.75
87.31
8.38
5.39
28.3

AA024658
47
ribosomal protein S19
7.55
0.00592
278.11
120.83
373.3
7.62
5.03
10.68

AA029288
65
EST
3.36
0.04908
134.53
56.15
209.69
4.09
3.35
8.39

AA037828
88
KIAA0614 protein
#N/A
#N/A
53.61
46.86
41.68
13.32
10.65
11.96

AA040465
95
EST
3.63
0.01806
229.8
210.67
180.94
47.15
45.53
5.48

AA053660
128
EST
#N/A
#N/A
543.66
223.47
685.44
95.24
79.97
42.99

cAMP responsive element binding protein 3

AA136332
299
(luman)
#N/A
#N/A
49.04
33.07
31.07
−18.27
−20.23
13.05

AA149530
324
interferon regulatory factor 3
#N/A
#N/A
32.94
23.12
34.23
4.21
5.38
8.53

AA149586
325
EST
#N/A
#N/A
24.99
26.6
34.37
5.26
9.11
23.41

AA206023
427
EST
#N/A
#N/A
154.13
170.36
85.33
108.57
111.76
58.39

AA234530
484
N-ethylmaleimide-sensitive factor
#N/A
#N/A
143.67
135.48
82.59
51.33
42.9
35.02

AA251909
549
EST
3.59
0.01129
92.19
79.34
72.73
8.88
11.22
8.27

AA262030
605
EST
#N/A
#N/A
119.75
89.66
103.84
31.51
32.91
14.46

AA262477
608
ribonuclease HI, large subunit
4.57
0.00724
242.42
199.5
182.26
44.51
36.87
22.37

AA283759
671
EST
#N/A
#N/A
91.82
76.73
42.28
46.87
45.86
21.54

AA291644
701
EST
3.28
0.00033
114.73
117.29
44.59
32.77
30.24
21.1

AA338760
744
EST
3.96
0.01307
129.77
130.26
87.27
14.91
21.91
26.96

AA398205
789
EST
4.22
0.00059
125.4
107.84
63.85
15.01
7.37
26.26

tumor suppressor deleted in oral cancer-

AA401965
833
related 1
7.58
0.00089
932.74
924.02
593.69
120.58
93.29
109.41

AA402272
837
EST
3.73
0.02336
348.91
340
230.15
99.7
92.28
80.27

AA404597
854
EST
#N/A
#N/A
609.98
525.02
371.31
379.26
336.33
167.43

AA417030
914
EST
7.35
0.00555
200.3
168.21
135.63
6.42
7.5
7.77

AA423820
940
EST
#N/A
#N/A
111.38
111.23
120.84
41.9
21.93
44.58

AA425852
958
EST
3.82
0.0395
131.52
95.35
166.76
7.02
5.22
4.75

AA430032
1009
pituitary tumor-transforming 1
10.67
0.00052
377.69
320.44
294.49
26.8
15.31
35.24

AA430673
1017
EST
#N/A
#N/A
45.74
34.15
44.8
−1.21
3.63
15.26

AA443321
1076
EST
#N/A
#N/A
33.93
32.89
11.76
10.79
9.65
7.26

tumor suppressing subtransferable

AA443941
1085
candidate 1
#N/A
#N/A
97.74
103.38
47.48
31.09
34.9
16.61

AA447223
1100
EST
#N/A
#N/A
31.66
18.91
31.1
4.45
3.74
6.5

AA449431
1124
translation initiation factor IF2
3.76
0.00571
94.41
95.64
54.08
17.4
16.96
5.38

AA454597
1166
EST
4.23
0.00917
342.59
311.81
207.71
66.6
57.29
23.41

AA458882
1205
EST
#N/A
#N/A
93.56
52.28
98.72
24.97
22.52
17.66

AA458934
1208
EST
#N/A
#N/A
33.6
28.19
29.02
7.1
7.91
4.22

AA465342
1271
EST
3.21
0.01378
131.07
109.99
95.4
30.07
33.06
23.97

AA477561
1292
EST
#N/A
#N/A
146.3
127.03
97.99
63.83
76.56
37.87

calcium/calmodulin-dependent protein

AA491295
1390
kinase kinase 2, beta
3.71
0.0103
180.61
173.47
118.85
46.95
31.51
65.56

RAD51 (S. cerevisiae) homolog (E coli RecA

AA608545
1462
homolog)
#N/A
#N/A
70.5
57.51
53.36
7.76
8.92
6.17

AA620553
1504
flap structure-specific endonuclease 1
7.56
0.00101
262.87
232.63
201.66
14.44
4.85
38.53

AA621325
1522
HNK-1 sulfotransferase
#N/A
#N/A
74.57
70.64
46.61
27.23
25.89
16.03

AA621780
1530
CGI-96 protein
#N/A
#N/A
81.72
92.23
49.69
12.06
11.27
19.2

F02807
1781
KIAA0838 protein
5.67
0.02064
260.02
219.01
229.96
20.93
16.66
22.24

F04444
1788
EST
4.13
0.00944
371.21
360.5
186.45
119.68
121.27
109.82

F04524
1790
stomatin-like protein 1
#N/A
#N/A
117.77
135.65
68.29
46.56
44.53
33.75

F08876
1797
EST
9.06
0
209.64
201.85
53.21
−22.5
−20.17
37.21

F10161
1811
EST
#N/A
#N/A
50.78
46.73
32.42
15.4
14.78
11.87

F10453
1819
EST
3.64
0.01878
135.07
138.53
85.7
27.28
14.2
54.04

H04649
1838
EST
#N/A
#N/A
180.25
158.18
164.34
50.86
41.2
33.9

H04793
1840
DKFZP434F091 protein
#N/A
#N/A
23.18
20
41.25
−14.45
−20.45
29

H59617
1964
EST
5.81
0.0115
212.68
209.19
157.42
19.24
21.65
16.88

H97012
2058
EST
3.51
0.03505
171.34
138.12
170.68
27.69
38.46
36.08

H98657
2068
EST
#N/A
#N/A
141.17
131.42
69.63
111.2
84.74
128.92

N23319
2453
EST
#N/A
#N/A
70.62
66.39
49.4
13.74
8.56
21.62

N23868
2458
EST
#N/A
#N/A
79.69
81.67
56.06
20.52
20.19
11.48

N45224
2515
EST
#N/A
#N/A
349.73
360.67
164.87
215.49
223.16
151.06

N48595
2527
EST
#N/A
#N/A
85.77
67.62
51.78
28.84
29.38
8.3

N75541
2691
EST
4.43
0.01059
182.83
131.35
183.41
34.1
15.82
56.07

N90273
2712
ras homolog gene family, member H
#N/A
#N/A
105.53
96.01
41.89
68.92
59.56
35.69

N93465
2734
EST
#N/A
#N/A
803.68
716.56
385.5
624.57
694.14
306.11

R39191
2833
KIAA1020 protein
5.18
0.03185
331.72
80.62
590.96
17.46
18.33
16.04

R44793
2858
EST
5.4
0.00329
155.86
121.83
125.26
10.1
7.86
16.54

R44817
2859
EST
#N/A
#N/A
594.46
602.82
206.15
255.91
249.29
69.09

R44896
2861
KIAA0665 gene product
#N/A
#N/A
67.08
57.13
34.18
19.1
20.75
23.04

R64137
2930
EST
#N/A
#N/A
31.25
24.23
21
2.9
2.65
6.94

R71395
2951
EST
4.12
0.03719
166.03
99.42
190.98
14.99
12.28
14.58

R72087
2954
EST
#N/A
#N/A
262.11
302.11
95
201.97
183.76
83.41

R91819
2983
EST
12.81
0.00037
467.79
364.2
426.16
11.34
9.35
36.49

T03749
3047
KIAA1089 protein
4.23
0.00776
103
97.55
74.34
−5.18
−6.08
13.69

T25744
3091
EST
#N/A
#N/A
72.74
73.3
37.84
15.56
12.65
13.18

T62918
3168
EST
5.25
0.00687
136.22
142.37
83.63
−12.41
−6.89
17.59

T89731
3244
EST
#N/A
#N/A
63.59
65.07
20.47
5.75
3.83
11.8

zinc metalloproteinase, STE24 (yeast,

W32176
3497
homolog)
#N/A
#N/A
550.53
614.92
234.79
290.18
277.95
129.45

rab6 GTPase activating protein (GAP and

W47388
3533
centrosome-associated)
#N/A
#N/A
97.33
71
59.73
43.93
36.52
48.34

W78057
3597
EST
5.53
0.01231
265.23
222.35
199.24
29.21
29.9
34.33

W80763
3605
EST
4.98
0.01026
147.37
138.37
122.38
16.84
15.48
9.22

W90146
3641
EST
3.58
0.00322
82.11
69.02
47.2
9.93
8.63
6.49

Z38299
3884
EST
3.71
0.0036
140.86
127.16
96.62
30.48
25.94
23.34

Z38404
3885
EST
#N/A
#N/A
59.77
56.71
37.29
29.82
30.16
9

Z38462
3889
KIAA0938 protein
4.69
0.0142
137.19
116.11
116.16
−0.86
0.53
7.64

Z38688
3890
EST
#N/A
#N/A
49.85
46.83
42.25
21.38
13.4
29.47

Z38729
3891
EST
#N/A
#N/A
77.67
57.81
60.7
−2.4
−5.01
46.96

Z40556
3918
CGI-96 protein
#N/A
#N/A
176.19
76.96
285.02
59.62
55.07
16.66

AA021549
42
EST
3.17
0.00158
100.01
83.02
44.39
31.74
20.12
36.74

AA026270
56
tyrosyl-tRNA synthetase
#N/A
#N/A
269.96
261.31
191.51
76.85
76.68
45.22

AA055896
135
collagen, type V, alpha 1
10.87
0.00907
414.16
454.82
330.75
−3.14
−5.8
33.88

AA112979
225
vaccinia related kinase 1
#N/A
#N/A
37.93
31.05
16.86
8.54
8.02
2.59

AA134063
286
EST
#N/A
#N/A
25.71
13.84
34.35
−5.21
−6.17
6

AA150053
327
EST
#N/A
#N/A
270.14
248.87
144.92
101.87
88.37
73.73

AA206914
428
EST
#N/A
#N/A
89.35
94.1
46.27
66.34
69.2
26.35

AA243133
525
serine/threonine kinase 15
7.03
0.00005
147.5
162.28
43.03
9.69
12.1
9.8

AA243466
527
EST
#N/A
#N/A
61.94
42.38
37.6
13.66
13.42
9.63

AA243598
531
EST
#N/A
#N/A
60.15
62.79
32.67
11.41
13.18
13.43

AA252147
551
EST
#N/A
#N/A
95.91
56.69
122.31
3.65
−0.82
22.5

AA255566
570
EST
#N/A
#N/A
64.28
50.15
52.25
16.18
14.38
13.17

AA279667
629
EST
#N/A
#N/A
184.99
102.43
289.71
8.06
7.61
23.78

AA279943
635
EST
#N/A
#N/A
137.05
63.54
232.2
−4.7
−5.33
11.18

AA290594
691
EST
#N/A
#N/A
59.19
56.31
23.84
21.4
18.8
23.98

AA290776
693
EST
#N/A
#N/A
524.07
516.6
88.67
441.83
355.04
245.84

AA292765
712
ZW10 interactor
7.24
0.00498
202.52
192.15
142.78
11.33
18.29
13.27

AA398908
801
EST
20.72
0.00114
629.56
433.87
551.97
−174.29
−216.08
104.42

AA405098
855
EST
6.09
0.01224
221.56
130.95
237.73
−4.35
−8.44
30.78

AA406542
878
EST
#N/A
#N/A
179.08
84.98
218.93
−1.99
1.49
12.75

AA435738
1042
EST
#N/A
#N/A
80.97
82
30.96
50.41
51.29
33.08

AA443585
1077
EST
#N/A
#N/A
200.3
136.72
140.42
118.18
97.38
102.71

Ts translation elongation factor,

AA446596
1092
mitochondrial
#N/A
#N/A
103.35
97.42
153.31
72.58
70.64
154.24

AA447777
1107
EST
#N/A
#N/A
258.37
212.57
171.93
133.78
116.63
56.34

AA453757
1156
EST
#N/A
#N/A
128.41
118.8
40.54
65.66
70.33
40.45

AA459254
1211
EST
6.22
0.00001
309.74
308.36
112.62
51.84
43.51
37.57

AA459673
1220
chromosome-associated polypeptide C
#N/A
#N/A
32.11
31.27
15.41
8.91
6.74
8.86

AA476333
1282
EST
#N/A
#N/A
52.26
34.54
55.5
9.04
14.67
24.04

AA496993
1405
EST
#N/A
#N/A
91.01
73.62
80.93
24.83
12.83
29.07

AA504512
1415
KIAA0943 protein
5.72
0.00384
316.32
322.55
180.22
65.48
28.37
93.94

AA609132
1479
EST
#N/A
#N/A
67.33
42.61
65.11
29.14
23.25
53.79

AA609942
1494
EST
#N/A
#N/A
89.98
66.8
71.4
15.89
14.41
25.58

F02254
1777
Fas-activated serine/threonine kinase
5.1
0.00329
376.8
341.06
145.28
90
72.97
135.39

H48459
1937
KIAA0186 gene product
3.1
0.02325
71.21
49.95
87.89
−29.4
−30.17
6.19

H87790
2018
EST
#N/A
#N/A
284.91
287.54
145.66
466.07
547.34
192.71

N34017
2493
EST
#N/A
#N/A
39.35
37.49
4.67
5.47
7.05
10.01

N35493
2501
EST
#N/A
#N/A
73.6
80.62
31.24
19.03
18.75
17

N63604
2600
EST
#N/A
#N/A
47.18
32.72
35
16.51
14.36
10.5

N63646
2601
EST
#N/A
#N/A
479.9
367.24
240.56
182.22
137.95
90.9

N69014
2641
SRY (sex-determining region Y)-box 22
#N/A
#N/A
193.21
174.83
48.23
116.34
129.47
50.74

N69879
2650
drebrin 1
3.15
0.01659
88.78
84.86
61.76
3.69
−2.94
21.49

N69983
2651
EST
#N/A
#N/A
93.25
96.86
49.82
76.2
93.14
54.92

N70330
2655
EST
#N/A
#N/A
108.39
69.74
105.54
33.78
27.33
16.47

N74018
2683
EST
#N/A
#N/A
22.65
25.34
10.26
2.34
1.47
10.41

N89670
2708
EST
#N/A
#N/A
65.03
59.18
66.58
3.16
−1.81
43.32

N93000
2726
EST
#N/A
#N/A
77.68
64.15
45.06
17.65
18.66
10.91

N99944
2748
EST
3.46
0.00104
211.02
200.61
102.49
60.05
50.12
29.73

R97176
3001
EST
#N/A
#N/A
143.07
152.08
86.96
53.41
58.26
38.91

T16226
3065
EST
7.23
0.00119
323.53
312.1
209.59
33.87
22.78
38.68

T32108
3102
EST
#N/A
#N/A
180.81
165.53
68.41
148.09
152.11
92.06

W15275
3471
EST
#N/A
#N/A
33.62
31.78
35.23
30.09
24.85
43.25

W31906
3496
secretagogin
6.62
0.00926
474.89
174.52
605.68
42.41
30.95
47.65

W46286
3523
EST
3.68
0.00311
154.73
166.08
72.64
23.51
22.85
61.89

DEAD/H (Asp-Glu-Ala-Asp/His) box

W60097
3553
polypeptide, Y chromosome
4.82
0.04903
235.42
265.15
189.13
35.34
11.72
84.5

KDEL (Lys-Asp-Glu-Leu) endoplasmic

W80852
3606
reticulum protein retention receptor 3
6.37
0.00005
184.61
159.98
100.74
11.16
11.92
36.06

AA046745
113
Wolf-Hirschhorn syndrome candidate 1
3.33
0.00648
73.04
72.71
48.97
10.59
12.02
7.33

AA052941
121
EST
3.36
0.00088
100.81
106.86
44.56
25.66
25.65
13.62

AA058589
144
EST
#N/A
#N/A
44.63
51.66
34.1
−9.37
−10.9
8.66

AA126561
249
stanniocalcin
#N/A
#N/A
51.44
44.19
31.6
7.16
7.73
8.55

AA146849
313
target of myb1 (chicken) homolog
4.72
0.00326
398.05
341.23
244.73
98.86
106.97
86.19

AA149889
326
neighbor of A-kinase anchoring protein 95
8.55
0.00224
240.81
312.86
143.89
−0.24
8.25
29.83

AA283711
669
ubiquitin carrier protein
#N/A
#N/A
382.91
380.33
210.95
221.7
203.51
93.54

AA284153
673
EST
#N/A
#N/A
117.98
127.81
72.86
53.98
43.58
32.17

AA335191
741
creatine kinase, brain
6.47
0.01462
512.64
199.99
673.92
43.84
33.21
43.52

AA402642
840
TNF receptor-associated factor 1
#N/A
#N/A
137.67
59.13
211.07
35.93
19.15
31.32

ATP-binding cassette, sub-family F

AA427460
972
(GCN20), member 2
#N/A
#N/A
190.92
187.57
78.83
92.5
83.63
49.3

AA431429
1021
EST
#N/A
#N/A
25.39
21.98
9.32
5.32
4.23
4.43

v-Ha-ras Harvey rat sarcoma viral oncogene

AA443316
1075
homolog
3.4
0.00133
138.89
124.06
70.22
40.07
41.12
32.54

AA476260
1280
EST
#N/A
#N/A
61.23
69.49
40.45
−32.66
−15.85
56.91

AA487058
1352
ubiquitin-conjugating enzyme E2L 3
#N/A
#N/A
245.56
225.48
137.4
315.7
232.85
213.47

AA521149
1420
EST
3.33
0.00211
113.43
106.74
60.79
28.44
29.54
18.61

AA599244
1448
KIAA0530 protein
#N/A
#N/A
53.83
48.84
25.7
7.71
6.06
7.11

AA599850
1457
EST
3.55
0.03215
122.91
75.32
123.52
−1.23
−2.33
31.86

AA621530
1526
EST
3.26
0.00298
78.73
75.43
40.45
12.46
15.12
13.43

AA621644
1528
EST
#N/A
#N/A
83.13
88.29
43.19
71.19
66.84
29.87

C15078
1573
EST
#N/A
#N/A
121.71
98.25
100.16
26.22
31.14
60.2

D80710
1734
integral type I protein
3.17
0.04549
153.76
74.74
166.28
22.95
28.29
24.59

D80948
1738
EST
#N/A
#N/A
70.05
77.71
32.11
41.25
43.53
17.46

D81048
1739
EST
#N/A
#N/A
150.18
149.32
51.77
86.08
85.08
39.11

F04320
1786
replication factor C (activator 1) 4 (37kD)
6.29
0.00042
156.76
122.53
109.02
14.92
17.26
9.79

H14617
1884
EST
#N/A
#N/A
143.86
147.93
66.03
133.9
150.35
53.38

H26763
1907
EST
#N/A
#N/A
408.05
321.65
219.8
409.85
391.85
155.84

H68794
1984
EST
3.67
0.00327
215.75
176.78
110.42
65.56
54
51.09

H78211
2001
EST
7.5
0.02674
285.43
307.06
261.02
−115.95
−129.18
70.22

H95566
2050
EST
#N/A
#N/A
136.58
143.31
26.27
74.11
89.04
126.61

H99870
2082
EST
#N/A
#N/A
92.81
94.93
33.98
53.96
61.17
29.86

N62487
2590
EST
#N/A
#N/A
56.6
52.26
33.75
13.89
16.02
8.53

N67815
2626
EST
3.84
0.00439
351.55
356.17
99.35
104.07
151.77
86.01

N69084
2642
EST
3.11
0.0094
233.32
208.16
169.31
72.13
67.7
49.99

N73278
2671
EST
#N/A
#N/A
77.72
71.59
49.4
25.36
19.22
26.85

R06251
2763
tumor protein D52-like 2
4.88
0.03097
466.88
341.39
380.43
74.25
66.72
64.11

carbohydrate (keratan sulfate Gal-6)

R15740
2790
sulfotransferase 1
3.36
0.00268
117.43
100.03
64.73
31.77
21.3
33.53

R24507
2801
EST
#N/A
#N/A
31.61
16.41
30.69
3
3.45
5.62

R27296
2806
EST
3.41
0.00309
77.08
67.51
39.42
8.27
11.07
7.26

R30931
2809
EST
#N/A
#N/A
54.19
57.09
29.34
17.58
13.67
14.21

R45994
2866
EST
6.48
0.00358
730.52
598.82
420.14
145.88
160.69
163.03

R70253
2944
EST
3.38
0.03125
99.7
88.01
87.93
−9.59
−0.47
30.83

R72886
2955
KIAA0422 protein
5.5
0.00091
564.05
473.4
207.71
126.66
121.18
116.07

R96924
3000
EST
7.04
0.00012
336.8
329
106.3
51.01
52.94
54.09

T15852
3061
EST
5.21
0.00642
168.18
134.42
120.18
−7.59
7.36
51.48

cleavage and polyadenylation specific factor

T16983
3073
4, 30kD subunit
4.23
0.0106
262.26
268.2
155.86
65.64
45.67
74.28

T33865
3109
RNA (guanine-7-) methyltransferase
#N/A
#N/A
29.73
32.86
22.11
−0.26
2.33
8.15

T66935
3178
EST
3.01
0.00123
181.34
189.67
61.49
66.8
52.94
42.32

T95057
3258
EST
6.46
0.00613
229.11
188.71
174.46
7.13
15.37
37.2

W45320
3520
KRAB-associated protein 1
10.05
0.00002
365.22
345.46
124.13
−2.52
25.03
112.32

AF006041
1549
death-associated protein 6
#N/A
#N/A
174.22
170.16
37.64
74.91
58.55
50.31

D00596
1590
thymidylate synthetase
5.58
0.0098
200.17
128.11
170.5
20.16
20.43
12.43

D38491
1653
KIAA0117 protein
#N/A
#N/A
47.67
52.03
21.01
20.77
20.88
17.43

D63486
1712
KIAA0152 gene product
3.56
0.00063
277.42
248.24
99.25
84.6
95.61
45.48

minichromosome maintenance deficient

D84557
1749
(mis5, S.pombe) 6
3.97
0.0017
184.48
132.11
125.74
37.22
43.12
28.15

D86957
1754
KIAA0202 protein
3.08
0.02949
91.22
73.14
89.89
14.7
12.7
6.29

D86972
1755
KIAA0218 gene product
#N/A
#N/A
68.56
66.54
32.32
34.58
32.05
21.82

D90097
1768
amylase, alpha 2B; pancreatic
#N/A
#N/A
41.19
37.49
21.85
6.55
11.44
15.06

L29218
2190
CDC-like kinase 2
3.82
0.00035
155.42
142.58
76.28
35.11
41.27
26.41

L38696
2208
RNA-binding protein (autoantigenic)
#N/A
#N/A
127.32
114.91
62.34
60.18
58.55
24.77

M11749
2240
Thy-1 cell surface antigen
#N/A
#N/A
83.1
65.86
64.52
26.05
28.95
20.56

M25753
2308
cyclin B1
#N/A
#N/A
44.14
30.96
40.36
−0.8
3.03
15.35

M32334
2333
intercellular adhesion molecule 2
#N/A
#N/A
95.04
92.33
67.51
42.19
41.31
27.33

M55210
2353
laminin, gamma 1 (formerly LAMB2)
3.47
0.02551
137.63
115.85
102.71
27.07
29.17
12.36

M61916
2372
laminin, beta 1
3.18
0.01171
75.1
67.4
61.41
7.19
7.98
8.99

stress-induced-phosphoprotein 1

M86752
2411
(Hsp70/Hsp90-organizing protein)
5.15
0.02881
216.51
248.21
192.98
8.67
20.63
39.03

M87339
2414
replication factor C (activator 1) 4 (37kD)
4.59
0.00116
110.39
82.61
79.29
4.26
9.92
16.79

M94250
2425
midkine (neurite growth-promoting factor 2)
9.86
0.02104
690.32
193.74
1414.43
−155.4
−175.43
101.89

S72904
3030
cytosolic ovarian carcinoma antigen 1
#N/A
#N/A
29.33
29.21
18.34
11.53
12.85
7.55

S78187
3035
cell division cycle 25B
4.83
0.00547
143.52
115.3
109.13
3.36
−1.2
26.9

S78569
3036
laminin, alpha 4
#N/A
#N/A
25.79
26.91
21.66
6.3
7.6
9.38

U38847
3356
TAR (HIV) RNA-binding protein 1
#N/A
#N/A
83.43
70.23
66.3
15.7
17.43
10.2

U51477
3383
diacylglycerol kinase, zeta (104kD)
#N/A
#N/A
73.85
61.64
31.81
36.35
36.29
23.02

DEAD/H (Asp-Glu-Ala-Asp/His) box

U59321
3397
polypeptide 17 (72kD)
3.12
0.02469
84.5
98.2
70.13
3.1
−1.83
19.73

gamma-aminobutyric acid (GABA) A

U66661
3405
receptor, epsilon
3.55
0.0045
97.79
83.66
61.79
16.58
14.81
11.96

U93237
3461
multiple endocrine neoplasia I
#N/A
#N/A
84.78
93.3
24.25
45.63
45.39
17.66

X92106
3819
bleomycin hydrolase
#N/A
#N/A
56.15
48.48
36.93
4.73
3.77
11.78

tafazzin (cardiomyopathy, dilated 3A (X-

linked); endocardial fibroelastosis 2; Barth

X92762
3825
syndrome)
#N/A
#N/A
82.96
83.94
15.05
23.4
33.5
24.15

dual-specificity tyrosine-(Y)-phosphorylation

Y09216
3853
regulated kinase 2
#N/A
#N/A
47.87
47.61
18.08
18.99
22.48
13.31

guanine nucleotide binding protein (G

M69013
2390
protein), alpha 11 (Gq class)
#N/A
#N/A
86.89
70.61
47.65
38.18
47.33
23.06

AD000092
1542
RAD23 (S.cerevisiae) homolog A
#N/A
#N/A
97.12
98.23
25.66
37.18
32.35
28.04

small nuclear ribonucleoprotein 70kD

X04654
3678
polypeptide (RNP antigen)
#N/A
#N/A
122.45
134.9
49.51
42.22
41.24
17.18

myosin, light polypeptide 1, alkali; skeletal,

M31211
2326
fast
#N/A
#N/A
60.22
49.75
54.83
−2.19
−4.38
11.56

protein kinase, interferon-inducible double

U50648
3378
stranded RNA dependent
#N/A
#N/A
214.34
192.86
122.38
105.38
92.58
43.12

M74715
2394
iduronidase, alpha-L-
#N/A
#N/A
122.69
121.95
72.58
41.88
24.48
43.99

a disintegrin and metalloproteinase domain

U41767
3359
15 (metargidin)
#N/A
#N/A
196.76
147.11
113.93
83.03
66.93
68.33

M12125
2241
tropomyosin 2 (beta)
7.13
0.0004
174.25
183.97
95.24
13.01
16.33
11.64

sulfotransferase family 1A, phenol-

U20499
3320
preferring, member 3
#N/A
#N/A
141.35
126.33
135.57
48.34
54.37
24.69

[0137]

13

TABLE 8B

Genes and ESTs expressed only in Normal2 vs HCC2

hcc sample
hcc sample

hcc fold

hcc sample
set 2:
set 2: Std

Fragment Name
SEQ ID:
Known Gene Name
change
p value
set 2: Mean
Median
Dev
normal set 2: Mean
normal set 2: Median
normal set 2: Std Dev

H66367
1977
EST
3.84
0.00133
37.14
35.15
26.61
155.38
149.31
70.77

H72650
1994
EST
#N/A
#N/A
78.97
93.74
40.9
122
125
42.24

M30185
2321
cholesteryl ester transfer protein, plasma
3.82
0.00131
−15.66
−12.63
23.86
93.07
86.04
61.35

N99542
2746
orosomucoid 1
3.53
0.00607
61.09
67.97
39.3
226.06
187.68
146.11

T68083
3184
short-chain dehydrogenase/reductase 1
#N/A
#N/A
96.34
59.71
104.53
263.22
280.22
136.48

glucokinase (hexokinase 4) regulatory

Z48475
3940
protein
4.6
0.01693
65.99
51.37
146.72
305.23
239.52
155.98

AA046747
114
EST
4.77
0.00023
−0.57
3.68
23.81
113.78
88.54
66.41

AA253410
564
EST
#N/A
#N/A
3.66
1.48
10.67
49.37
26.82
45.2

AA281796
650
mannose-P-dolichol utilitzation defect 1
#N/A
#N/A
95.74
105.86
45.46
170.88
165.02
41.87

AA287566
690
KIAA0187 gene product
6.99
0.00023
18.67
14.05
35.71
246.24
201.66
228.64

AA404248
847
EST
#N/A
#N/A
24.05
30.59
15.83
40.92
35.06
17.49

AA448002
1113
putative type II membrane protein
14.14
0
39.9
38.99
13.33
594.13
528.63
282.58

AA487576
1357
EST
#N/A
#N/A
11.67
2.42
27.75
26.05
25.27
11.13

AA621235
1517
EST
#N/A
#N/A
65.79
68.63
35.33
114.75
113.36
65.35

F09979
1809
EST
#N/A
#N/A
61.21
6.31
128.69
226.47
116.41
288.21

H57056
1953
EST
#N/A
#N/A
−1.79
−7.37
11.38
35.07
38.32
17.88

H58673
1959
EST
15.49
0.00002
34.96
26.37
38.53
652.47
677.55
376.36

H59136
1962
EST
6.63
0.00033
33.12
21.17
42.92
250.23
229.94
129.12

H87765
2017
KIAA0626 gene product
3.94
0.00123
10.11
10.07
4.23
94.26
93.78
60.64

N22404
2449
EST
3.44
0.02267
56.69
35.82
73.26
193.63
130.09
162.83

N34919
2498
EST
#N/A
#N/A
19.32
19.72
14.37
52.96
44.23
24.23

N54604
2569
EST
#N/A
#N/A
45.27
14.34
81.45
133.06
119.1
109.95

N65959
2611
EST
3.38
0.00785
37.8
28.94
31.45
142.87
149.26
79.26

collectin sub-family member 10 (C-type

N74624
2687
lectin)
#N/A
#N/A
39.43
35.17
24.21
71.81
62.09
43.57

R09053
2782
EST
3.45
0.03074
64.12
36.33
102.03
186.87
204.61
113.19

R73816
2960
EST
7.05
0.01287
35.12
13.76
100.6
462.31
374.67
450.91

T58756
3155
EST
16.61
0
−1.02
1.06
24.36
390.04
386.76
164.41

W48860
3534
EST
#N/A
#N/A
37.25
31.7
27.5
52.69
41.31
21.1

W90018
3639
EST
#N/A
#N/A
21.51
1.31
56.9
59.32
53.19
41.68

AA010205
23
EST
5.71
0.00014
26.95
20.06
32.19
187.55
154.99
92.13

potassium voltage-gated channel, shaker-

AA013095
33
related subfamily, beta member 1,
#N/A
#N/A
5.12
7.9
12.98
18.56
15.83
8.24

macrophage receptor with collagenous

AA074885
161
structure
10.88
0.00087
35.67
58.01
44.34
652.03
761.74
300.57

AA099225
206
EST
6.59
0.00064
10.9
9.75
15.11
212.68
163.45
194.31

AA282541
661
EST
#N/A
#N/A
17.21
11.75
13.38
31.31
29.9
13.53

CD5 antigen-like (scavenger receptor

R99591
3015
cysteine rich family)
7.41
0.00043
124.14
139.76
50.35
1035.39
904.92
691.83

T68711
3187
EST
35.98
0.0003
29.03
−33.95
176.15
1388.67
1074.67
890.91

X-prolyl aminopeptidase (aminopeptidase P)

W78093
3598
2, membrane-bound
#N/A
#N/A
408.58
397.88
102.27
518.77
518.8
211.32

W85890
3620
EST
#N/A
#N/A
60.91
60.47
23.73
70.98
66.52
24.66

AA285053
681
EST
5
0.00718
36.49
20.15
49.24
238.16
242.27
169.12

AA460661
1229
EST
5.46
0.00151
20.05
8.57
39.04
184.62
198.21
108.17

butyrobetaine (gamma), 2-oxoglutarate

dioxygenase (gamma-butyrobetaine

F10380
1816
hydroxylase)
#N/A
#N/A
43.64
47.09
18.15
106.49
93.71
83.35

N67105
2623
EST
4.69
0.00194
12.46
10.45
12.64
143.36
102.9
121.4

nuclear receptor subfamily 1, group I,

N69114
2643
member 3
#N/A
#N/A
12.69
5.95
15.01
72.29
73.28
57.34

M63967
2378
aldehyde dehydrogenase 5
3.88
0.00274
40.43
30.04
29.05
164.38
178.74
87.39

X54380
3727
pregnancy-zone protein
7.71
0.00069
15.11
8.07
27.07
274.41
255.4
203.47

small inducible cytokine subfamily A (Cys-

Z49269
3942
Cys), member 14
7.24
0.01047
138.63
66.95
201.93
526.13
532.29
166.67

M10943
2234
metallothionein 1F (functional)
6.23
0.00007
35.67
28.76
22.4
217.65
186.71
86.73

[0138]

14

TABLE 9A

Genes and ESTs expressed only in Metastatic Liver Tumor vs Normal2

fold

change in

metastatic:
metastatic:
metastatic:

Fragment Name
SEQ ID:
Known Gene Name
metas
p value
Mean
Median
Std Dev
normal set 2: Mean
normal set 2: Median
normal set 2: Std Dev

diptheria toxin resistance protein required for

diphthamide biosynthesis (Saccharomyces)-like

AA009913
21
2
#N/A
#N/A
69.53
81.03
27.69
16.81
18.22
13.51

AA127712
255
EST
6.59
0.03706
332.45
208.85
296.68
−29.54
−28.71
104.37

adaptor-related protein complex 1, gamma 1

AA253330
562
subunit
3.87
0.00708
219.95
186.12
141.92
47.32
51.59
30.28

AA291456
700
EST
3.96
0.03633
1808.4
1273.75
1481.84
671.21
509.58
629.13

AA295819
722
EST
8
0.01793
230.14
251.43
146.89
−14.93
−20.8
19.72

differentially expressed in hematopoietic

AA372630
769
lineages
25.49
0.01743
2094.32
436.62
3873.61
6.67
4.87
7.16

AA384184
774
DKFZP586B0519 protein
3.38
0.01209
476.17
411.64
148.86
181.02
188.54
135.4

AA427468
973
claudin 4
84.43
0
5646.4
5344.98
1581.19
72.58
64.85
87.74

AA454908
1171
KIAA0144 gene product
9.3
0.00539
320.03
253.32
238.5
−33.7
−46.73
73.56

AB002304
1534
KIAA0306 protein
#N/A
#N/A
584.5
621.94
136.64
313.99
298.88
88.6

AB002349
1537
KIAA0351 gene product
#N/A
#N/A
65.63
52.11
32.26
49.37
46.52
37.93

AF003521
1545
jagged 2
11.26
0.00008
426
330.95
309.91
15.48
−3.6
91.81

C00808
1553
EST
#N/A
#N/A
122.57
118.32
53.36
91.65
87.87
32.51

C14228
1567
EST
#N/A
#N/A
39.93
33.15
13.59
−0.51
2.85
8.61

trinucleotide repeat containing 11 (THR-

D83783
1748
associated protein, 230 kDa subunit)
6.55
0.00176
236.64
156.39
216.64
23.23
19.65
27.84

D88154
1766
villin-like
4.18
0.00051
117.8
129.16
47.7
23.85
18.99
17.79

H43286
1929
gamma-aminobutyric acid (GABA) B receptor, 1
5.02
0.01972
377.04
222.91
315.96
57.02
63.58
24.25

H53657
1945
adenylate cyclase 3
3.98
0.0045
140.07
111.99
74.77
31.33
31.74
15.29

L08044
2149
trefoil factor 3 (intestinal)
21.42
0.01674
2956.22
1618.2
3127.19
107.82
58.55
184.16

pregnancy specific beta-1-glycoprotein

M94891
2428
4, pregnancy specific beta-1-glycoprotein 7
#N/A
#N/A
221.09
197.74
80.32
178.23
166.98
61.33

R56678
2907
EST
3.81
0.02242
98.37
78.38
75.74
2.67
5
5.82

R69700
2942
EST
6.71
0.0021
387.34
393.81
94.86
79.33
57.85
129.97

R76363
2961
EST
#N/A
#N/A
47.81
38.04
24.76
12.67
16.94
13.17

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide

U75968
3422
11 (S.cerevisiae CHL1-like helicase)
#N/A
#N/A
195.48
155.37
89.8
115.5
102.24
77.72

W95348
3660
HSPC113 protein
10.89
0.01065
555.52
492.63
563.86
26.59
29.36
21.03

AA007160
16
EST
6
0.01035
171.32
175.07
138.03
9.1
8.6
12.54

AA024482
45
DKFZP434G032 protein
#N/A
#N/A
207.37
118.58
230.63
−1.3
−3.13
13.6

AA040465
95
EST
3.25
0.00146
161.91
125.35
72.19
47.15
45.53
5.48

AA053660
128
EST
15.98
0.00003
1573.49
1340
820.5
95.24
79.97
42.99

carcinoembryonic antigen-related cell adhesion

AA100719
212
molecule 6 (non-specific cross reacting antigen)
50.88
0.00081
1405.2
1264.79
1137.97
−17.03
−22.23
16.43

AA115979
232
mitotic spindle coiled-coil related protein
#N/A
#N/A
74.58
89.38
66.52
22.91
13.67
29.42

AA134968
289
EST
12.11
0.00079
322.34
208.47
256.66
10.04
7.96
15.53

AA179787
380
polyglutamine binding protein 1
6.44
0.00206
191.33
171.71
138.9
−11.56
−12.46
42.46

AA227926
460
EST
6.81
0.01701
228.91
120.1
243.92
16.24
14.21
6.86

AA235707
500
EST
9.17
0.00005
189.42
161.88
57.05
−18.19
−19.06
14.8

AA236533
514
ecotropic viral integration site 1
4.01
0.02882
106.15
76.05
78.18
−16.45
−14.04
8.52

AA243173
526
EST
8.75
0.00003
384.86
482.53
162.08
41.66
40.74
27.31

AA262943
611
EST
13.42
0.00234
430.7
207.29
511.01
−1.08
−6.93
19.06

AA281214
643
neuroblastoma-amplified protein
#N/A
#N/A
130.98
133.63
68.42
69.89
53.91
39.31

AA282505
659
EST
#N/A
#N/A
461.54
478.83
622.39
−41.45
−17
98.17

AA292931
715
EST
3.97
0.00067
230.65
260.43
79.42
57.32
61.89
18.62

AA372018
768
EST
14.3
0.00178
363.44
220.03
261.04
−2.44
−3.09
8.36

AA394121
778
laminin receptor 1 (67kD, ribosomal protein SA)
23.78
0.00099
788.51
677.33
612.74
0.21
−8.38
31.59

AA399226
803
tight junction protein 3 (zona occludens 3)
3.59
0.02002
89.54
78.97
63.98
−5.01
−6.48
11.33

tumor suppressor deleted in oral cancer-related

AA401965
833
1
#N/A
#N/A
384.12
271.95
444.06
120.58
93.29
109.41

AA404597
854
EST
#N/A
#N/A
624.37
495.56
274.8
379.26
336.33
167.43

AA410469
883
EST
6.3
0.00103
337.03
250.11
264.1
50.51
42.79
60.18

AA419217
923
DKFZP586E1422 protein
6.77
0.00045
276.53
215.37
172.25
36.93
36.7
21.88

AA424881
949
EST
6.3
0.00556
158.13
155.45
82.63
−16.85
−22.15
20.49

AA425852
958
EST
4.8
0.03874
149.8
125.7
128.03
7.02
5.22
4.75

AA430674
1018
EST
15.11
0.00293
454.82
306.15
378.36
−71.57
−82.03
59.56

AA442763
1072
cyclin B2
5.09
0.02168
136.16
109.91
91.52
−14.64
−15.1
13.08

AA443941
1085
tumor suppressing subtransferable candidate 1
3.57
0.01685
137.02
138.22
83.35
31.09
34.9
16.61

AA449456
1126
EST
6.29
0.00087
847.4
775.81
377.99
160.93
178.76
112.71

AA451877
1138
EST
8.63
0.00489
239.55
157.3
244.02
−27.28
−27.59
18.28

AA454597
1166
EST
3.63
0.0067
268.15
274.94
167.72
66.6
57.29
23.41

AA457235
1200
EST
#N/A
#N/A
481.26
138.32
573.73
11.06
17.32
15.26

AA460666
1231
EST
#N/A
#N/A
56.19
58.13
26.29
−24.55
−17.23
20.98

AA463861
1251
EST
24.79
0.00096
672.22
311.71
641.54
−22.02
−20.04
16.5

AA464962
1264
EST
#N/A
#N/A
61.02
56.4
30.98
20.99
14.37
19.64

AA465342
1271
EST
#N/A
#N/A
113.36
100.15
87.62
30.07
33.06
23.97

AA465660
1273
LIM domain binding 1
#N/A
#N/A
171.26
118.15
103.39
124.59
105.93
56.71

tumor necrosis factor receptor superfamily,

member 12 (translocating chain-association

AA476749
1286
membrane protein)
#N/A
#N/A
53.23
44.04
18.16
25.5
29.62
11.96

AA477561
1292
EST
#N/A
#N/A
160.87
104.95
133.7
63.83
76.56
37.87

AA482546
1336
KIAA0124 protein
4.41
0.00604
181.72
113.91
140.73
38.26
30.26
32.72

AA609795
1492
EST
#N/A
#N/A
74.38
34
77.76
−41.44
−45.5
28.82

AA621277
1520
EST
3.81
0.00194
81.18
74.81
30.84
−0.15
1.98
12.84

procollagen-proline, 2-oxoglutarate 4-

dioxygenase (proline 4-hydroxylase), alpha

F09788
1808
polypeptide II
4.14
0.00003
104.92
112.31
27.67
19.92
20.29
13.83

H09281
1863
EST
6
0.00966
147.11
187.25
71.67
−2.97
−0.54
11.7

H59617
1964
EST
3.3
0.04588
116.07
71.39
101
19.24
21.65
16.88

H98657
2068
EST
#N/A
#N/A
179.15
192.17
32.25
111.2
84.74
128.92

N22015
2447
EST
46.61
0.00025
1225.51
887.65
1106.3
−5.3
−6.84
18.82

N35376
2500
EST
#N/A
#N/A
39.01
35.99
19.81
28.53
29.44
8.2

N63165
2597
EST
#N/A
#N/A
68.04
62.1
44.7
30.07
26.23
13.84

N64616
2610
EST
3.11
0.0074
68.89
75.8
32.12
−0.83
9.77
28.69

N66951
2620
EST
5.54
0.02442
451.16
432.45
381.81
59.83
75.27
32.75

solute carrier family 11 (proton-coupled divalent

N72116
2667
metal ion transporters), member 2
9.01
0.00051
338.43
314.06
196.66
32.57
29.68
20.1

N92659
2720
EST
#N/A
#N/A
31.19
37.23
14.14
5.91
4.05
5.63

R06866
2773
EST
5.18
0.00187
148.48
114.86
102.01
18.26
15.16
17.11

R26744
2803
midline 1 (Opitz/BBB syndrome)
4.32
0.00532
112.54
90
76.53
−0.2
−3.06
24.42

R36109
2822
EST
#N/A
#N/A
47.54
48.43
19.9
25.67
20.25
34.73

protein similar to E.coli yhdg and R. capsulatus

R38511
2831
nifR3
5.19
0.00015
131.5
147.54
44.02
21.3
23.75
9.22

R39191
2833
KIAA1020 protein
4.69
0.00456
130.93
145.31
62.13
17.46
18.33
16.04

R40057
2838
prominin (mouse)-like 1
#N/A
#N/A
47.6
46.28
36.57
0.83
−0.8
7.91

R44817
2859
EST
#N/A
#N/A
600.1
550.42
309.14
255.91
249.29
69.09

Fc fragment of lgG, low affinity IIIa, receptor for

R49047
2877
(CD16)
#N/A
#N/A
44.49
36.71
14.37
15.43
14.16
14.13

ubiquitin specific protease 7 (herpes virus-

R54935
2902
associated)
#N/A
#N/A
75.76
81.15
31.57
17.77
14
18.86

R55470
2903
EST
3.59
0.00515
256.38
225.69
138.22
75.29
73.42
53.04

R59093
2910
EST
#N/A
#N/A
57.79
33.48
73.58
12.26
10.21
7.73

R63925
2928
EST
#N/A
#N/A
70.52
60.93
15.36
49.82
52.73
13.77

R71395
2951
EST
10.42
0.00422
318.75
274.93
227.75
14.99
12.28
14.58

R85266
2976
EST
#N/A
#N/A
53.4
54.53
25.44
48.68
39.83
33.9

R91819
2983
EST
8.95
0.00009
263.33
219.91
135.67
11.34
9.35
36.49

T03438
3042
EST
8.18
0.00032
300.09
229.6
218.02
31.03
28.88
15.86

T03541
3044
EST
#N/A
#N/A
455.39
418.21
288.45
155.27
155.62
50.93

T25744
3091
EST
#N/A
#N/A
79.78
68.72
52.01
15.56
12.65
13.18

T53404
3142
EST
10.68
0.00582
654.13
475.25
687.49
48.3
0.6
93.06

T91116
3251
EST
4.01
0.02721
133.54
61.72
126.12
16.62
11.42
13.64

T96060
3262
EST
#N/A
#N/A
910.76
225.75
1282.67
67.92
70.44
91.72

W02695
3466
EST
#N/A
#N/A
129.58
99.52
100.52
30.69
33.06
16.14

W67251
3567
EST
6.13
0.01463
204.71
182.17
127.82
21.77
23.88
12.17

W78057
3597
EST
9.06
0.0034
397.29
374.78
305.93
29.21
29.9
34.33

W90146
3641
EST
6.23
0.01558
170.66
147.78
126.32
9.93
8.63
6.49

W92449
3649
EST
31.67
0.00011
715.17
491.5
459.71
−40.13
−40.74
17.76

Z39191
3898
EST
8.84
0.00011
442.36
371.88
228.18
46.98
49.3
33.31

Z39569
3906
EST
#N/A
#N/A
166.55
125.78
217.77
−9.57
−12.15
17.32

Z41415
3930
EST
#N/A
#N/A
199.73
88.96
271.2
10.38
6.64
11.47

AA026030
53
EST
11.01
0.01649
566.65
284.32
828.49
3.02
4.66
40.87

AA026270
56
tyrosyl-tRNA synthetase
#N/A
#N/A
201.1
224.51
50.82
76.85
76.68
45.22

AA043944
100
EST
#N/A
#N/A
52.9
29.13
46.43
3.69
3.15
7.26

AA053102
125
cadherin 17, LI cadherin (liver-intestine)
26.63
0.01745
1053.43
972.71
785.51
4.92
4.94
9.04

AA053248
126
EST
7.01
0.00003
2234.44
1595.15
1053.3
341.06
304.8
189.89

AA055896
135
collagen, type V, alpha 1
18.16
0.00146
540.67
538.43
382
−3.14
−5.8
33.88

AA084343
178
EST
#N/A
#N/A
133.86
126.19
19.99
84.58
76.82
41.45

AA112979
225
vaccinia related kinase 1
#N/A
#N/A
25.08
24.98
13.02
8.54
8.02
2.59

AA126041
244
EST
#N/A
#N/A
42.91
33.83
16.2
26.42
28.92
9.81

amyloid beta (A4) precursor protein (protease

AA128553
260
nexin-lI, Alzheimer disease)
#N/A
#N/A
87.35
102.82
24.17
114.91
108.16
30.28

AA150053
327
EST
3.71
0.00102
309.61
304.16
82.48
101.87
88.37
73.73

AA151428
335
matrix metalloproteinase 23B
7.15
0.00056
174.77
131.66
104.51
3.23
10.67
24.39

AA156243
340
serine protease, umbilical endothelium
41.44
0.00139
1255.4
547.15
1189.26
9.32
11.44
9.39

AA159525
354
EST
49.39
0.00062
1309.05
1107.08
965.67
−32.72
−28.32
20.11

AA161043
356
tetraspan 1
18.8
0.00015
1477.19
932.02
1467.59
70.82
58.62
42.88

AA171760
367
EST
17.86
0
645.43
578.38
312.37
28.03
16.24
57.21

AA179845
381
EST
5.77
0.01414
280.06
335.41
172.62
37.43
37.69
14.87

AA181600
384
EST
5.38
0.03316
166.88
94.16
153.49
−40.51
−47.81
24.34

AA196790
421
EST
7.64
0.00287
239.45
275.18
142.37
22.91
26.8
10.54

AA211483
435
EST
44.07
0.00175
1300.23
1303.61
1051.58
−29.25
−34.99
17.49

AA232508
464
EST
#N/A
#N/A
464
533.98
266.87
170.48
156.89
104.75

general transcription factor IIIC, polypeptide I

AA233290
469
(alpha subunit, 220kD)
#N/A
#N/A
56.54
43.91
22.15
28.32
31.59
25.36

AA234096
479
EST
23.72
0.00018
607.06
420.34
366.53
−3.47
1.73
30.91

AA234346
480
EST
#N/A
#N/A
36.98
39.47
12.81
6.21
6.79
19.99

AA234362
481
EST
3.89
0.03524
116.26
75.37
105.77
−1.86
−4.2
16.67

survival of motor neuron protein interacting

AA234365
482
protein 1
#N/A
#N/A
56.37
42.6
34.73
12.96
16.93
12.99

AA234706
488
EST
#N/A
#N/A
68.33
53.21
21.55
49.66
39.76
42.06

AA253473
567
EST
15.23
0.00171
375.2
435.68
216.18
−4.38
−3.19
12.35

AA255566
570
EST
#N/A
#N/A
63.43
65.2
30.17
16.18
14.38
13.17

AA256642
582
EST
11.17
0.00035
266.31
275.43
135.85
0.78
−1.34
15.74

AA292765
712
ZW10 interactor
7.14
0.02623
230.83
166.72
232.16
11.33
18.29
13.27

AA331393
739
EST
16.73
0.00848
600.02
315.98
598.52
5.08
3.88
9.43

AA349792
759
mutY (E. coli) homolog
#N/A
#N/A
525.17
553.97
245.2
221.5
212.24
98.86

AA398908
801
EST
38.69
0.01089
1678.58
1796.68
1500.48
−174.29
−216.08
104.42

AA405715
862
hypothetical protein
4.68
0.00898
152.23
138.92
96.78
24.47
27.3
11.75

AA406542
878
EST
8.27
0.00724
230.18
170.94
206.8
−1.99
1.49
12.75

AA421562
934
anterior gradient 2 (Xenepus laevis) homolog
56.3
0.0041
2556.78
792
3323.39
14.22
15.72
6.54

AA424487
945
EST
38.41
0.00002
2689.32
1863.02
1900.51
67.92
61.95
46.24

AA425279
951
quiescin Q6
6.15
0.00083
221.93
181.8
167.44
18.33
22.33
44.81

serine/threonine kinase 24 (Ste20, yeast

AA425401
954
homolog)
3.22
0.00625
246.6
166.4
175.99
76.4
78.33
43.72

AA429009
994
serine protease inhibitor, Kunitz type 1
30.04
0.00001
1010.32
1100.19
472.23
−2.97
−24.67
62.21

AA436616
1056
EST
3.18
0.04402
79.96
91.35
62.83
−0.73
3.24
15.36

AA447687
1104
EST
11.42
0.00362
306.28
178.65
244.12
−16.27
−14.45
8.55

AA447991
1112
EST
4.99
0.00173
279.79
234.63
161.24
64.49
40.73
53.34

AA459254
1211
EST
5.36
0.0259
403.69
194.85
401.21
51.84
43.51
37.57

AA478556
1303
EST
#N/A
#N/A
172.35
135.55
120.49
143.25
134.62
109.1

AA491208
1388
chromosome 6 open reading frame 1
#N/A
#N/A
159.88
143.86
80.49
123.37
131.81
47.97

AA599585
1454
EST
#N/A
#N/A
66.17
48.91
48.12
−12.47
−17.55
21.82

C21248
1585
pituitary tumor-transforming 1
3.85
0.00456
100.24
96.81
47.17
−1.7
−11.27
28.49

D20906
1627
EST
5.18
0.02189
210.11
151.67
185.24
14.87
11.71
27.2

F02330
1778
EST
#N/A
#N/A
199.08
170.47
83.95
178.42
195.54
58.6

F03811
1784
KIAA0440 protein
#N/A
#N/A
638.66
598.46
142.63
235.37
232.6
47.16

F04531
1791
Kell blood group precursor (McLeod phenotype)
7.79
0.03205
311.05
366.72
262.03
16.22
20.65
13.52

F09394
1803
KIAA0715 protein
22.89
0.01753
865.39
696.47
631.83
−49.72
−50.25
35.81

H43646
1930
H2A histone family, member Y
4.6
0.00147
413.02
424.34
219.27
92.12
91.3
52.41

v-myb avian myeloblastosis viral oncogene

N49284
2536
homolog
11.82
0.01981
510.82
523.45
423.41
−36.17
−50.08
50.71

N54265
2562
EST
#N/A
#N/A
45.56
44.98
19.91
17.71
26.43
25.36

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide

N62675
2593
16
3.61
0.04034
109.44
104.65
108.08
6.49
15.91
35.18

N73846
2679
EST
3.27
0.00012
78.37
79.7
20.06
14.43
14.3
17.21

N89670
2708
EST
4.26
0.00002
115.98
108.4
29.79
3.16
−1.81
43.32

protein tyrosine phosphatase type IVA, member

N93798
2737
3
4.65
0.00118
557.51
523.56
229.03
139.69
122.61
84.93

R33498
2819
EST
41.34
0.00001
1839.74
1920.41
1082.84
46.45
33.01
43.64

R44479
2854
KIAA0552 gene product
4.14
0.0181
97.01
105.95
60.51
7.08
5.99
7.62

matrix metalloproteinase 12 (macrophage

R92994
2989
elastase)
11.05
0.00248
312.14
252.62
248.32
11.43
6.64
11.52

R95966
2996
EST
11.22
0.00682
482.68
436.3
446.39
−106.64
−160.75
127.91

T30222
3099
EST
#N/A
#N/A
35.41
34.75
27.14
8.47
9.56
17.71

T32108
3102
EST
6.96
0.00723
1095.16
593.52
923.47
148.09
152.11
92.06

T89601
3242
EST
#N/A
#N/A
839.07
747.51
231.92
410.07
342.22
200.88

leukemia inhibitory factor (cholinergic

W46451
3526
differentiation factor)
#N/A
#N/A
120.95
76.95
88.42
36.63
40.09
21.06

W60968
3556
EST
#N/A
#N/A
125.7
144.72
48.22
51.99
55.29
21.11

W93726
3653
protease inhibitor 5 (maspin)
16.48
0.00014
355.41
304.26
149.69
−14.2
−14.8
10.59

W95477
3661
EST
26.51
0.00161
941.08
566.6
1130.33
17.15
18.75
12.83

AA011134
29
EST
28.79
0.00602
1157.47
566.78
1448.16
−72.57
−51.2
69.3

glutamate-cysteine ligase (gamma-

glutamylcysteine synthetase), regulatory

AA035540
81
(30.8kD)
#N/A
#N/A
39.84
34.37
13.29
13.59
12.27
8.96

AA053033
124
EST
7.83
0.00379
212.61
135.28
160.82
3.41
−1.28
19.74

AA055805
132
EST
42.83
0.00142
1270.03
1026.97
1179.12
−11.11
−10.85
20.27

AA055811
133
glycoprotein A33 (transmembrane)
6.86
0.02152
236.18
196.53
171.06
14.84
17.82
17.5

AA131162
266
EST
4.68
0.00042
117.43
123.78
39.05
11.86
13.57
19.83

AA157857
350
keratin 19
#N/A
#N/A
2728.74
2917.98
1076.95
−13.21
−14.4
15.84

AA252994
557
apoptosis inhibitor 4 (survivin)
3.55
0.00075
152.63
140.53
31.01
50.23
40.59
35.61

WW domain binding protein 4 (formin binding

AA258836
601
protein 21)
#N/A
#N/A
41.9
44.58
13.6
26.08
23.64
10.4

AA291259
697
putative G protein-coupled receptor
#N/A
#N/A
112.28
45.1
113.44
1.53
1.88
6.06

AA335191
741
creatine kinase, brain
47.35
0.00419
3540.65
3971.43
3135.19
43.84
33.21
43.52

AA422086
938
EST
10.71
0.03418
828.27
598.22
800.79
39.48
34.98
23.29

cytochrome P540 family member predicted from

AA422150
939
ESTs
17.14
0.00108
664.26
609.99
475.91
28.76
27.53
22.47

ATP-binding cassette, sub-family F (GCN20),

AA427460
972
member 2
#N/A
#N/A
215.08
135.22
216.95
92.5
83.63
49.3

AA427636
976
EST
19.23
0.00145
511.98
500.83
299.69
6.19
3.7
15.84

AA429890
1004
cisplatin resistance associated
12.51
0.00053
1225.72
590.09
992.47
90.02
67.23
59.35

v-Ha-ras Harvey rat sarcoma viral oncogene

AA443316
1075
homolog
4.13
0.01729
191.06
173.3
113.42
40.07
41.12
32.54

AA599244
1448
KIAA0530 protein
3.39
0.01246
77.48
78.85
37.98
7.71
6.06
7.11

AA609013
1477
dipeptidase 1 (renal)
10.17
0.00109
1185.55
1222.89
634.13
114.31
98.91
75.22

AA620497
1503
EST
#N/A
#N/A
147.72
165.83
66.02
95.91
76.7
80.33

AA620995
1512
EST
3.74
0.03414
100.71
80.15
101.95
3.5
1.8
3.77

C15078
1573
EST
#N/A
#N/A
115.08
73.82
91.34
26.22
31.14
60.2

D80710
1734
integral type I protein
7.08
0.00213
253.6
303.7
149.08
22.95
28.29
24.59

D80948
1738
EST
#N/A
#N/A
82.4
67.39
42.83
41.25
43.53
17.46

F04320
1786
replication factor C (activator 1) 4 (37kD)
3.63
0.01119
90.37
115.96
49.41
14.92
17.26
9.79

H03629
1834
desmin
#N/A
#N/A
52.19
58.52
35.47
−1.96
−2.94
8.58

H11760
1878
EST
#N/A
#N/A
70.59
62.53
58.16
9.96
8.19
11.54

E74-like factor 4 (ets domain transcription

H24269
1902
factor)
#N/A
#N/A
51.79
47.58
24.25
15.19
16.8
12.36

H57709
1956
ribosomal protein L31
#N/A
#N/A
47.56
34.17
56.68
4.55
2.44
52.46

solute carrier family 2 (facilitated glucose

H58873
1961
transporter), member 1
57.98
0.00063
4996.66
4603.55
4107.24
69.89
70.74
58.94

H78211
2001
EST
6.73
0.02488
211.51
183.81
208.45
−115.95
−129.18
70.22

N54395
2564
EST
#N/A
#N/A
49.95
46.84
48.26
−16.14
−17.71
6.65

N92734
2721
EST
#N/A
#N/A
45.63
39.49
14.19
27.31
25.45
10.41

R06251
2763
tumor protein D52-like 2
5.57
0.00037
343.86
381.79
95.11
74.25
66.72
64.11

R27296
2806
EST
#N/A
#N/A
41.82
39.83
32.72
8.27
11.07
7.26

calcium channel, voltage-dependent, beta 3

R36947
2824
subunit
4.11
0.00006
101.82
109.62
28.57
−0.61
0.94
37.6

R96924
3000
EST
6.18
0.03417
451.59
490.51
339.66
51.01
52.94
54.09

T15473
3057
muscle specific gene
5.81
0.02404
189.25
139.11
184.39
−5.65
−10.77
15.89

cleavage and polyadenylation specific factor 4,

T16983
3073
30kD subunit
5.23
0.00075
268.21
300.53
81.43
65.64
45.67
74.28

T30193
3097
protease, serine, 8 (prostasin)
8.39
0.00043
1912.22
1228.46
1739.5
214.88
175.57
127.28

T47601
3125
EST
4.05
0.00878
199.79
219.84
62.16
84.5
28.33
122.16

T66935
3178
EST
3.97
0.00188
253.93
230.32
129.66
66.8
52.94
42.32

W73189
3586
EphB2
3.69
0.02909
113.63
144.75
67.73
20.7
23.2
15.44

D13435
1605
phosphatidylinositol glycan, class F
#N/A
#N/A
80.8
88.58
41.56
34.85
41.76
18.11

D14520
1613
basic transcription element binding protein 2
4.93
0.00004
151.12
135.19
57.24
25.67
17.28
25.67

minichromosome maintenance deficient (S.

D21063
1628
cerevisiae) 2 (mitotin)
3.83
0.00983
91.18
55.12
60.89
−51.33
−62.63
28.4

D50914
1673
KIAA0124 protein
4.74
0.00752
116.55
91.64
89.27
−17.4
−17.86
16.97

063486
1712
KIAA0152 gene product
6.33
0.00078
543.91
676.55
287.16
84.6
95.61
45.48

D63880
1715
KIAA0159 gene product
4.26
0.00253
93.03
103.26
41.4
−2.12
−4.45
9.38

D79992
1724
KIAA0I70 gene product
#N/A
#N/A
35.23
42.16
14.88
22
18.09
11.9

D79997
1725
K1AA0175 gene product
#N/A
#N/A
55.25
42.49
53.87
8.57
6.15
13.07

D83735
1747
calponin 2
10.42
0.00001
486.85
436.55
172.25
42.54
43.06
57.58

minichromosome maintenance deficient (mis5,

D84557
1749
S. pombe) 6
#N/A
#N/A
142.92
125.75
102.81
37.22
43.12
28.15

D87073
1759
zinc finger protein 142 (clone pHZ-49)
#N/A
#N/A
40.84
34.37
13.36
33.34
33.07
21.13

J04469
2111
creatine kinase, mitochondrial 1 (ubiquitous)
7.9
0.00705
212.04
143.89
162.12
−17.21
−18.81
12.68

J05257
2118
dipeptidase 1 (renal)
12.02
0.02099
429.91
300.76
352.56
−21.05
−21.78
30.67

IMP (inosine monophosphate) dehydrogenase

J05272
2119
1
#N/A
#N/A
269.89
205
173.64
126.69
106.27
82.73

ribosomal protein S6 kinase, 90kD, polypeptide

L07597
2146
1
#N/A
#N/A
36.09
29.39
44.43
−12.04
−10.72
11.97

L11669
2157
tetracycline transporter-like protein
6.75
0.00101
218.77
261.77
115.8
26.26
25.92
17.48

matrix metalloproteinase 12 (macrophage

L23808
2179
elastase)
6.18
0.02195
175.24
161.83
132.75
−9.99
−8.2
8.11

ribose 5-phosphate isomerase A (ribose 5-

L35035
2201
phosphate epimerase)
#N/A
#N/A
64.36
69.69
40.9
11.52
12.58
6.43

endothelial cell protein C/activated protein C

L35545
2202
receptor
#N/A
#N/A
66.65
55.46
68.13
7.75
5.68
11.48

L38696
2208
RNA-binding protein (autoantigenic)
3.7
0.00093
230.48
161.69
118.85
60.18
58.55
24.77

L41351
2214
protease, serine, 8 (prostasin)
6.34
0.01132
214.13
104.95
189.28
10.88
9.6
22.68

M15205
2265
thymidine kinase 1, soluble
3.75
0.00159
153.15
150.31
66.27
41.98
35.02
29.02

carcinoembryonic antigen-related cell adhesion

M18728
2285
molecule 6 (non-specific cross reacting antigen)
44.82
0.00291
1390.62
1362.73
1031.01
−9.17
−13.17
11.83

M25629
2307
kallikrein 1, renal/pancreas/salivary
#N/A
#N/A
47.43
40.22
29.15
−2.42
2.12
15.6

M27826
2313
endogenous retroviral protease
26.36
0.00342
993.89
833.56
816.33
5.88
7.04
32.2

carcinoembryonic antigen-related cell adhesion

M29540
2317
molecule 5
36.57
0.0116
1516.55
1083.69
1372.55
−1.09
−3.15
11.75

M87339
2414
replication factor C (activator 1) 4 (37kD)
4.07
0.00316
93.72
78.1
56.58
4.26
9.92
16.79

M94250
2425
midkine (neurite growth-promoting factor 2)
10.39
0.01818
442.2
188.32
624.9
−155.4
−175.43
101.89

M94345
2426
capping protein (actin filament), gelsolin-like
22.38
0.00003
503.47
539.15
179.05
−7.51
−10.35
22.75

M94362
2427
lamin B2
#N/A
#N/A
175.16
154.32
75.52
79.2
81.73
34.64

M95623
2430
hydroxymethylbilane synthase
#N/A
#N/A
67.65
72.44
22.29
6.67
0.88
24.92

S78187
3035
cell division cycle 25B
8.07
0.00009
198.51
218.04
74.52
3.36
−1.2
26.9

U01062
3272
inositol 1,4,5-triphosphate receptor, type 3
7.41
0
160.46
164.36
23.91
−16.8
−26.61
26.44

U01147
3274
active BCR-related gene
3.22
0.00103
97.43
84.12
41.43
27.15
22.94
17

tumor necrosis factor (ligand) superfamily,

U03398
3281
member 9
#N/A
#N/A
116.17
88.07
59.5
115.08
92.7
93.14

U04313
3283
protease inhibitor 5 (maspin)
4.54
0.02986
132.77
69.67
115.99
−0.34
−2.59
9.7

U16306
3311
chondroitin sulfate proteoglycan 2 (versican)
#N/A
#N/A
48.35
56.91
35.99
8.07
4.58
16.58

laminin, beta 3 (nicein (125kD), kalinin (140kD),

U17760
3314
BM600 (125kD))
3.54
0.01853
103.13
111.96
72.83
6.99
−3.15
21.08

epithelial protein up-regulated in carcinoma,

U21049
3324
membrane associated protein 17
7.53
0.01667
202.38
248.15
119.31
−14.32
−12.21
19.43

U38847
3356
TAR (HIV) RNA-binding protein 1
#N/A
#N/A
72.74
66.76
36.14
15.7
17.43
10.2

potassium voltage-gated channel, KQT-like

U40990
3358
subfamily, member 1
3.18
0.00093
128.02
142.31
43.16
40.88
42.64
23.09

U51095
3381
caudal type homeo box transcription factor 1
4.76
0.02664
130.81
143.82
93.4
5.83
5.55
8.97

U53786
3389
envoplakin
#N/A
#N/A
221.51
73.95
249.37
−20.54
−20.08
16.22

gamma-aminobutyric acid (GABA) A receptor,

U66661
3405
epsilon
#N/A
#N/A
55.33
44.93
29.26
16.58
14.81
11.96

O-linked N-acetylglucosamine (GlcNAc)

transferase (UDP-N-

acetylglucosamine:polypeptide-N-

U77413
3426
acetylglucosaminyl transferase)
#N/A
#N/A
59.38
59.78
48.05
1.2
5.23
13.8

U89606
3451
pyridoxal (pyridoxine, vitamin B6) kinase
3.58
0.00322
103.6
97.56
58.85
15.19
18.94
24.5

X13956
3698
EST
3.2
0.00321
79.19
75.13
39.53
15.11
18.02
14.55

X14850
3703
H2A histone family, memberX
4.11
0.0001
118.41
97.53
52.6
11.6
13.26
30.46

v-abl Abelson murine leukemia viral oncogene

X16416
3710
homolog 1
#N/A
#N/A
82.49
90.74
16.7
36.59
38
14.59

X57766
3742
matrix metalloproteinase 11 (stromelysin 3)
#N/A
#N/A
166.25
142.96
124.34
63.38
62.13
25.48

X63629
3759
cadherin 3, P-cadherin (placental)
3.02
0.01654
67.22
76.67
29.17
−4.24
−6.82
16.9

X67325
3772
interferon, alpha-inducible protein 27
9.67
0.03245
962.87
412.22
1361.55
26.81
48.73
69.77

X76180
3792
sodium channel, nonvoltage-gated 1 alpha
11.68
0
320.05
268.84
127.86
22.38
23.9
15.02

FXYD domain-containing ion transport regulator

X93036
3827
3
42.36
0.00167
1322.91
783.61
1219
−83.87
−85.84
40.53

Y00503
3846
keratin 19
14.19
0.00217
362.5
427.85
240.73
7.02
10.74
10.98

SRY (sex-determining region Y)-box 9

(campomelic dysplasia, autosomal sex-

Z46629
3935
reversal)
#N/A
#N/A
39.69
40.61
13.99
6.21
8.06
9.16

lectin, galactoside-binding, soluble, 9 (galectin

AB006782
1541
9)
#N/A
#N/A
475.47
430.44
192.68
222.25
213.37
51.25

X83228
3807
cadherin 17, LI cadherin (liver-intestine)
10.58
0.02147
342.12
423.87
282.49
−8.87
−6.9
8.55

HMT1 (hnRNP methyltransferase, S.

Y10807
3857
cerevisiae)-like 2
4.28
0.00124
393.27
449.97
142.94
96
90.42
44.52

U48705
3369
discoidin domain receptor family, member 1
5.94
0.01323
178.04
200.63
102.82
−1.87
−6.25
25.81

small nuclear ribonucleoprotein 70kD

X04654
3678
polypeptide (RNP antigen)
#N/A
#N/A
98.11
89.35
38.15
42.22
41.24
17.18

CD44 antigen (homing function and India

HG2981-HT3127

blood group system)
#N/A
#N/A
48.43
47.46
47.03
8.05
9.25
7.17

HG371-HT26388

mucin 1, transmembrane
8.44
0.00268
310.61
203.35
303.26
19.1
2.63
34.66

J05582
2121
mucin 1, transmembrane
5.39
0.00056
114
114.74
42.09
−6.01
−4.53
13.68

M16364
2269
creatine kinase, brain
12.69
0.03633
683.38
491.19
929.94
−72.18
−70.9
40.37

X54667
3728
cystatin S, cystatin SN
8.53
0.00059
273.96
169.94
217.11
−10.09
−15.68
74.89

M29277
2316
melanoma adhesion molecule
3.91
0.00112
269.54
313.13
82.76
80.09
81.21
48.32

X57348
3741
stratifin
12.53
0.0013
308.28
241.69
194.79
−63.66
−76.43
44.95

U07969
3288
cadherin 17, LI cadherin (liver-intestine)
10.78
0.02002
428.65
383.68
390.23
15.78
12.82
12.06

M12125
2241
tropomyosin 2 (beta)
10.83
0.00191
291.63
158.55
229.08
13.01
16.33
11.64

transcription factor 3 (E2A immunoglobulin

M31523
2329
enhancer binding factors E12/E47)
#N/A
#N/A
59.78
62.53
10.63
18.65
21.63
8.94

X99133
3839
lipocalin 2 (oncogene 24p3)
6.27
0.0453
284.56
129.1
434.01
−28.39
−19.41
26.24

sulfotransferase family 1A, phenol-preferring,

U20499
3320
member 3
5.5
0.00299
316.7
231.67
222.02
48.34
54.37
24.69

L42583
2215
keratin 6A
#N/A
#N/A
116.33
111.15
91.3
60.92
51.12
22.52

[0139]

15

TABLE 9B

Genes and ESTs expressed only in Normal2 vs Metastatic Liver Tumor

fold

change in

metastatic:
metastatic:
metastatic:

Fragment Name
SEQ ID:
Known Gene Name
metas
p value
Mean
Median
Std Dev
normal set 2: Mean
normal set 2: Median
normal set 2: Std Dev

microvascular endothelial differentiation gene

AA027766
58
1
#N/A
#N/A
16.71
16.37
7.36
25.05
26.19
13.26

AA028976
63
EST
#N/A
#N/A
9.46
10.28
18.91
72.06
47.28
55.89

NADH dehydrogenase (ubiquinone) 1 beta

AA041208
96
subcomplex, 8 (19kD, ASHI)
#N/A
#N/A
234.76
302.34
215.51
448.34
390
234.61

AA044095
102
EST
#N/A
#N/A
29.41
18.4
35.04
31.85
24.92
38.98

AA044842
105
Autosomal Highly Conserved Protein
5.21
0.0009
16.66
16.52
18
167.15
159.32
123.77

AA047151
116
EST
7.13
0.00007
17.55
17.5
10.09
188.62
185.41
80.5

AA056319
139
EST
#N/A
#N/A
21.89
17.62
12.89
29.23
26.53
11.96

AA092376
196
15 kDa selenoprotein
#N/A
#N/A
16.78
14.2
28.1
59.07
57.94
24.97

AA092596
197
bone morphogenetic protein 6
3.46
0.02532
30.18
22.69
61.67
148.47
171.15
77.57

AA092716
198
HLA-B associated transcript-3
13.97
0.00009
62.83
63.53
42.33
952.09
817.41
545.31

AA143019
309
EST
6.75
0.00109
−0.4
−5.82
18.62
192.42
176.13
136.81

AA157401
346
S-adenosylhomocysteine hydrolase-like 1
#N/A
#N/A
15.44
13.27
14.06
61.17
65.58
27.48

AA174202
375
EST
#N/A
#N/A
55.99
38.87
72.55
120.99
128.88
62.33

eukaryotic translation initiation factor 4A,

AA195179
415
isoform 2
#N/A
#N/A
30.71
38.24
25.48
85.7
87.87
42.11

AA233225
468
MRS1 protein
#N/A
#N/A
25.16
30.66
26.03
54.1
55.8
22.69

CCAAT/enhancer binding protein (C/EBP),

AA234634
486
delta
7.48
0.03318
158.16
49.12
223.12
621.92
588.94
332.64

AA234687
487
EST
#N/A
#N/A
−8.8
−12.38
20.12
61.87
47.79
57.62

AA234817
490
EST
6.22
0.00099
31.51
20.97
34.92
222.41
156.99
133.06

AA247453
533
EST
3.09
0.0015
32.38
37.86
21.04
120.43
133.44
58.12

AA292440
709
DKFZP566B133 protein
#N/A
#N/A
122.1
125.27
37.73
370.32
318.31
181.37

AA296821
723
EST
#N/A
#N/A
15.47
10.65
21.91
57.72
71.28
33.61

AA298180
726
EST
3.11
0.00747
19.6
25.9
18.83
109.91
84.28
88.07

AA316272
734
fatty-acid-Coenzyme A ligase, long-chain 3
#N/A
#N/A
34.62
38.08
17.08
71.9
73.01
27.47

AA328684
737
EST
#N/A
#N/A
49.88
48.15
31.41
115.97
114.66
46.25

AA397841
780
EST
8.21
0
7.72
3.33
18.47
214.17
189.93
116.41

tumor necrosis factor alpha-inducible cellular

protein containing leucine zipper domains;

Huntingtin interacting protein L; transcrption

AA400333
815
factor IIIA-interacting protein
#N/A
#N/A
27.22
27.33
24.37
62.54
58.6
31.69

AA404214
846
EST
#N/A
#N/A
35.28
48.54
23.52
70.66
66.71
55.97

AA424307
944
EST
5.73
0.0074
44.98
21.05
54.01
202.82
194.92
68.07

AA447876
1109
EST
#N/A
#N/A
13.05
6.78
34.07
27.08
22.86
22.46

AA456687
1197
EST
3.08
0.01189
17.88
37.03
53.32
130.65
118.55
65.44

AA479266
1312
EST
#N/A
#N/A
18.04
21.7
25.73
42.53
38.32
18.46

AB000114
1532
osteomodulin
#N/A
#N/A
−2.62
−0.81
29.14
31.94
25.4
20.87

solute carrier family 4, sodium bicarbonate

AF007216
1550
cotransporter, member 4
5.79
0.00005
14.85
9.84
13.93
157.72
162.44
99.26

C02532
1563
EST
#N/A
#N/A
10.12
16.41
16.79
32.27
34.25
11.02

C15871
1575
EST
3.26
0.00046
13.83
18.19
16.99
79.77
83.41
40.17

C16420
1576
EST
5.95
0.00119
26.92
20.84
24.82
205.53
234.17
120.92

C18029
1577
tumor susceptibility gene 101
#N/A
#N/A
27.46
26.72
26.09
94.81
95.79
33.89

cytochrome P450, subfamily IVF,

polypeptide 2, cytochrome P450, subfamily

IVF, polypeptide 3 (leukotriene B4 omega

D12620
1601
hydroxylase)
35.09
0.00015
41.08
36.71
10.11
604.7
631.98
249.32

D13243
1602
pyruvate kinase, liver and RBC
20.22
0
−35.85
−34.85
51.7
579.28
445.53
502

D14012
1612
HGF activator
12.75
0.0035
160.15
216.05
107.03
1705.96
1963.23
794.42

D16626
1622
histidine ammonia-lyase
22.66
0
11.74
8.13
16.04
538.78
535.2
166.14

D16626
1622
histidine ammonia-lyase
22.66
0
12.06
22.91
55.95
289.6
256.22
113.59

D45288
1661
EST
#N/A
#N/A
−33.07
27.77
31.63
32.56
42.02

potassium inwardly-rectifying channel,

D50312
1669
subfamily J, member 8
#N/A
#N/A
−2.39
3.94
24.71
76.55
72.56
48.96

D57823
1690
Sec23 (S. cerevisiae) homolog A
4.43
0
13.37
13.08
8.38
94.25
87.66
30.56

D57916
1691
EST
#N/A
#N/A
67.05
42.08
79.49
126.25
103.85
69.38

D61991
1706
EST
4.84
0.00005
22.03
21.01
10.8
131.66
150.48
60.06

D62103
1707
EST
4.11
0.0263
96.52
111.02
79.07
349.4
258.95
229.11

H19089
1894
EST
#N/A
#N/A
76.83
44.82
89.14
76.54
74.4
40.21

H20627
1898
EST
#N/A
#N/A
30.59
30.04
23.84
79.8
87.46
43.37

H39627
1920
EST
#N/A
#N/A
73.92
101.48
54.09
155.43
158.44
39.98

H61002
1967
EST
#N/A
#N/A
68.96
23.38
102.25
88.87
93.79
36.34

H66367
1977
EST
6.68
0.0001
−5.44
−2.13
18.66
155.38
149.31
70.77

H72650
1994
EST
#N/A
#N/A
81.21
98.79
41.38
122
125
42.24

J00098
2086
apolipoprotein A-I, apolipoprotein C-Ill
#N/A
#N/A
96.71
29.74
269.46
9836.26
8356.89
8217.05

cytochrome P450, subfamily IIA

K03192
2127
(phenobarbital-inducible), polypeptide 6
69.92
0
3.07
9.83
30.14
1767.25
1790.36
741.7

cytochrome P450, subfamily IIA

K03192
2127
(phenobarbital-inducible), polypeptide 6
69.92
0
−1.32
−6.49
12.52
1087.08
1034.79
451.92

complement component 4-binding protein,

L11244
2155
beta
43.33
0
0.49
−8.84
36.95
1147.16
1114.71
441.14

complement component 4-binding protein,

L11244
2155
beta
43.33
0
-13.27
−16.78
12.92
292.9
341.12
114.93

L26336
2185
heat shock 70kD protein 2
#N/A
#N/A
15.67
14.08
10.72
31.12
33.86
10.1

nuclear factor of activated T-cells,

L41067
2213
cytoplasmic 3
4.96
0.00473
57.54
60.41
36.65
261.77
228.95
119.65

nuclear factor of activated T-cells,

L41067
2213
cytoplasmic 3
4.96
0.00473
30.25
13.66
32.44
73.87
77.38
52.02

L44424
2216
UMP-CMP kinase
#N/A
#N/A
23.79
18.2
26.85
57.57
43.3
36.92

protein C (inactivator of coagulation factors

M12712
2246
Va and VIIIa)
7.37
0.01866
107.12
177.74
113.63
646.94
628.19
326.15

M12759
2247
EST
#N/A
#N/A
27.23
21.91
28.99
97.65
103.06
53.91

glutathione S-transferase A2, glutathione S-

M14777
2263
transferase A3
#N/A
#N/A
−24.81
−27.52
27.54
2842.35
2790.19
1048.69

M16974
2277
complement component 8, alpha polypeptide
49.47
0.00046
28.24
−6.62
84.02
1843.82
1920.94
524.62

acyl-Coenzyme A dehydrogenase, C-2 to C-

M26393
2309
3 short chain
16.27
0.00007
16.81
12.39
48.16
677.3
775.54
358.47

M30185
2321
cholesteryl ester transfer protein, plasma
3.83
0.0013
−37.15
−29.18
28.09
93.07
86.04
61.35

cytochrome P450, subfamily IIC

M61854
2370
(mephenytoin 4-hydroxylase)
3.3
0.04185
52.7
55.56
44.01
321.6
166.36
430.71

M95767
2431
chitobiase, di-N-acetyl-
4.94
0.00004
26.01
37.13
21.53
173.07
153.03
95

N27670
2473
progesterone membrane binding protein
6.15
0.00321
38.66
15.48
47.19
252.94
292.34
133.48

N40320
2513
EST
7.56
0.01584
99.72
83.43
128.45
558.37
595.16
250.67

CCAAT/enhancer binding protein (C/EBP),

N57464
2575
delta
14.69
0.00018
22.28
11.43
38.78
429.29
442.58
169.83

N75120
2689
EST
#N/A
#N/A
20.59
23.42
10.65
61.42
58.88
13.84

N87590
2706
EST
#N/A
#N/A
1.04
−3.72
9.99
64.67
59.2
35.53

N94146
2738
EST
8.05
0
28.92
34.7
14.14
258.82
265.55
101.53

N99542
2746
orosomucoid 1
8.41
0.00001
6.74
10.14
21.89
226.06
187.68
146.11

R19808
2795
EST
#N/A
#N/A
9.95
12.2
25.55
27.53
25.43
10.61

R31641
2813
EST
9.96
0.00011
29.02
21.83
31.18
350.89
330.68
166.29

R63545
2926
EST
5.4
0.00202
2.58
9.54
17.4
157.98
128.33
139.55

R64534
2933
EST
#N/A
#N/A
12.11
14.54
5.77
40.32
40.98
17.27

differentially expressed in adenocarcinoma of

R71459
2952
the lung
#N/A
#N/A
16.9
11.46
16.47
37.42
30.98
20.83

R77539
2964
EST
#N/A
#N/A
5.91
14.55
25.48
70.5
59.8
31.72

R82229
2974
phosphatidylserine decarboxylase
3.08
0.03455
84.63
80.61
67.01
228.19
232.06
58.36

R98073
3008
EST
46.87
0
−4.33
−9.52
11.43
1161.51
1291.95
564.26

S62539
3021
insulin receptor substrate 1
3.7
0.01307
28.26
13.05
40.92
132.59
97.52
103.35

S72370
3029
pyruvate carboxylase
5.31
0.00075
3.83
5.81
23.1
113.03
118.49
50.19

T08879
3048
cathepsin F
5.29
0.0008
17.98
14.06
12.92
156.33
180.88
79.67

T57140
3151
paraoxonase 3
28.8
0
−1.37
−7.55
22.26
825.16
979.66
487.32

T68083
3184
short-chain dehydrogenase/reductase 1
4.03
0.01593
65.11
47.59
67.87
263.22
280.22
136.48

T68510
3186
EST
3.87
0.00617
0.88
−1.97
11.33
113.31
94.26
103.92

T69384
3197
period (Drosophila) homolog 1
5.88
0.01219
37.94
19.8
90.03
232.84
205.78
126.44

phytanoyl-CoA hydroxylase (Refsum

T83397
3232
disease)
63.6
0
−17.97
−4.64
35.51
1404.6
1421.69
605.99

T95813
3261
KIAA1051 protein
38.38
0.00008
56.83
42.22
56.86
2271.29
1809.29
1537.82

UDP glycosyltransferase 2 family,

U06641
3286
polypeptide B15
24.32
0.00001
56.39
62.92
54.9
1762.46
1615.25
1206.06

U06863
3287
follistatin-like 1
3.09
0.00091
43.48
45.73
14.83
141.97
149.4
59.45

U32576
3346
apolipoprotein C-IV
18.59
0.00005
311.97
318.75
271.42
1299.4
1145.33
698.02

U32576
3346
apolipoprotein C-IV
18.59
0.00005
−7.01
−23.2
62.7
606.88
608.66
224.72

myosin VIIA (Usher syndrome 1B (autosomal

U39226
3357
recessive, severe))
#N/A
#N/A
33.54
31.07
8.59
53.24
50.47
20.86

U56814
3392
deoxyribonuclease l-like 3
29.43
0.00003
5.04
11.75
22.3
853.78
1073.24
434.79

U59111
3396
dermatan sulphate proteoglycan 3
#N/A
#N/A
32.34
26.73
15.11
68.69
64.44
32.48

ATP-binding cassette, sub-family A (ABC1),

U66672
3406
member 5
#N/A
#N/A
78.03
41.24
72.76
105.45
97.64
60.15

glutamic-pyruvate transaminase (alanine

U70732
3414
aminotransferase)
27.63
0
−47.95
−65.21
50.88
696.22
732.8
284.7

glutamic-pyruvate transaminase (alanine

U70732
3414
aminotransferase)
27.63
0
−1.44
3.98
66.42
201.88
218.68
136.17

solute carrier family 9 (sodium/hydrogen

U82108
3440
exchanger), isoform 3 regulatory factor 2
3.19
0.01545
58.61
78.15
43.49
130.34
122.39
73.74

nephrosis 1, congenital, Finnish type

U95090
3463
(nephrin)
14.01
0.00018
40.49
30.15
38.71
554.93
539.41
183.55

nephrosis 1, congenital, Finnish type

U95090
3463
(nephrin)
14.01
0.00018
4.97
5.87
18.32
188.83
201.08
88.01

W02027
3464
EST
#N/A
#N/A
7.28
2.64
14.09
30.56
28.52
12.47

W03796
3467
EST
8.3
0.0032
8.13
−19.16
75.11
336.51
383.56
190.14

basic helix-loop-helix domain containing,

W16686
3475
class B, 2
#N/A
#N/A
46.29
−6.45
123.94
100.9
83.13
79.01

W27503
3485
KIAA0679 protein
#N/A
#N/A
17.31
17.31
21.95
27.71
27.51
5.28

W28235
3486
EST
#N/A
#N/A
95.97
150.37
81.4
271.36
307.26
108.42

W28824
3492
EST
15.8
0.00006
−1.99
−5.59
17.64
441.67
509.29
251

Kreisler (mouse) maf-related leucine zipper

W36290
3500
homolog
3.94
0.02718
48.52
10.45
73.21
157.7
156.24
65.15

W38778
3504
EST
#N/A
#N/A
−55.97
−63.87
44.35
78.01
37.07
137.01

CD36 antigen (collagen type I receptor,

thrombospondin receptor)-like 2 (lysosomal

W52581
3540
integral membrane protein II)
3.08
0.00091
10.92
8.89
10.63
71.35
58.02
37.28

W58520
3549
nucleoporin 88kD
#N/A
#N/A
24.77
26.75
16.56
81.88
87.47
37.77

W81053
3607
EST
4.91
0.00164
−21.38
−13.04
24.17
135.84
109.34
113.36

X02160
3668
insulin receptor
5.29
0.0001
10.06
8.21
10.89
77.32
65.71
45.53

cytochrome P450, subfamily IID

(debrisoquine, sparteine, etc., -metabolising),

X07618
3688
polypeptide 7a (pseudogene)
35.79
0.00065
59.61
12.32
101.97
1429.98
1631.04
671.55

cytochrome P450, subfamily IID

(debrisoquine, sparteine, etc., -metabolising),

X07618
3688
polypeptide 7a (pseudogene)
35.79
0.00065
40.81
38.21
14.35
609.22
605.91
330.02

X14787
3701
thrombospondin 1
3.69
0.01115
21.81
22.87
7.7
143.24
86.81
166.32

X16260
3707
inter-alpha (globulin) inhibitor, H1 polypeptide
44.65
0.00933
40.4
36.54
67
1261.99
1133
523.31

X60673
3749
adenylate kinase 3
8.3
0.00016
23.02
32.17
44.24
331.58
324.75
164.03

X92475
3821
ITBA1 gene
#N/A
#N/A
56.74
63.84
25.6
66.2
63.72
20.36

UDP glycosyltransferase 2 family,

Y00317
3842
polypeptide B4
18.34
0.00001
−9.82
−11.91
20.96
456.09
477.28
257.07

UDP glycosyltransferase 2 family,

Y00317
3842
polypeptide B4
18.34
0.00001
11.31
14.85
7.33
231.32
282.35
122.76

Y10659
3856
interleukin 13 receptor, alpha 1
4.22
0.00061
18.27
12.85
25.15
123.23
134.47
49.24

Y10659
3856
interleukin 13 receptor, alpha 1
4.22
0.00061
15.82
16.3
16.79
81.75
89.09
37.01

Y12711
3858
progesterone binding protein
14.83
0.00285
26.37
16.12
99.79
1061.83
935.43
829.85

Z29481
3874
3-hydroxyanthranilate 3,4-dioxygenase
6.39
0.00029
546.48
440.33
293.12
2012.12
1797.38
944.18

nuclear receptor subfamily 1, group I,

Z30425
3875
member 3
26.64
0
5.66
7.49
8.02
181.6
192.48
76.65

glucokinase (hexokinase 4) regulatory

Z48475
3940
protein
13.84
0
−42.61
−53.52
23.46
305.23
239.52
155.98

AA004707
10
copper chaperone for superoxide dismutase
#N/A
#N/A
217.76
217.72
144.41
502.14
479.38
161.01

AA005202
12
retinol-binding protein 4, interstitial
3.18
0.00106
43.46
41.24
9.66
163.36
107.5
110.2

AA010619
27
EST
8.55
0.00057
21.58
5.47
42.99
279.66
268.6
154.98

AA017146
36
EST
10.1
0.00052
30.35
22.85
50.05
414.24
435.09
193.39

AA019715
41
EST
#N/A
#N/A
8.03
8.03
6.49
15.9
14.58
7.82

AA024866
49
EST
#N/A
#N/A
10.89
7.87
8.56
31.16
30.56
14.26

AA025930
52
EST
3.59
0.00372
33.24
25.62
26.11
115.2
110.13
45.17

AA032250
73
EST
3.56
0.0009
10.56
13.86
9.55
84.44
83.69
50.06

AA043790
99
KIAA0937 protein
#N/A
#N/A
5.63
7.44
12.94
32.16
31.34
10.66

AA045481
107
EST
#N/A
#N/A
28.81
21.88
17.14
71.32
63.94
38.49

AA046747
114
EST
4.82
0.00022
−5.19
−4.2
10.73
113.78
88.54
66.41

AA053917
131
EST
#N/A
#N/A
−18.24
−11.6
21.61
56.08
38.68
82.71

AA055992
136
calumenin
3.51
0.00604
80.45
65.8
47.34
276.06
265.13
141.34

SEC24 (S. cerevisiae) related gene family,

AA056735
142
member D
#N/A
#N/A
4.59
10.03
14.42
29.84
28.43
10.97

AA076672
172
EST
#N/A
#N/A
86.18
87.53
60.88
122.82
105.84
54.8

AA084286
176
paternally expressed gene 3
#N/A
#N/A
−2.06
0.32
14.88
30.7
26.84
20.69

AA084318
177
EST
#N/A
#N/A
9.73
3.97
17.06
30.63
32.37
11.48

AA098864
205
EST
#N/A
#N/A
30.42
31.06
18.38
56.43
52.57
21.3

AA102098
218
EST
#N/A
#N/A
−1.8
−5.18
15.21
21.79
20.01
6.78

AA102571
220
EST
#N/A
#N/A
8.7
12.32
15.12
17.15
15.33
7.6

AA116075
234
EST
#N/A
#N/A
29.71
23.88
10
62.94
64.79
25.13

AA121140
235
EST
3.33
0.00058
6.67
5.82
3.73
74.84
83.56
31.9

AA121257
236
EST
#N/A
#N/A
21.76
21.21
32.49
42.39
43.62
11.55

sequence-specific single-stranded-DNA-

AA128177
258
binding protein
#N/A
#N/A
11.71
6.05
16.96
44.4
33.57
33.54

calcitonin receptor-like receptor activity

AA133215
277
modifying protein 1
4.55
0.02092
76.1
37.86
72.97
250.94
266.82
64.2

AA136611
303
EST
#N/A
#N/A
9.05
6.82
8.39
48.23
42.67
13.53

AA136940
305
EST
#N/A
#N/A
40.81
41.78
20.7
79.13
73.37
41.89

AA147626
316
EST
#N/A
#N/A
37.93
20.43
44.09
82.38
75.98
37.45

AA147646
317
DKFZP586A0522 protein
21.82
0
15.59
14.85
24.51
610.52
685.45
288.9

AA148480
318
flavin containing monooxygenase 5
19.64
0
18.26
14.26
14.85
521.95
407.11
247.99

AA148539
319
EST
#N/A
#N/A
9.96
9.87
8.65
28.88
25.89
6.73

AA150205
328
EST
#N/A
#N/A
−1.1
−1.72
9.15
8.12
7.44
9.59

AA150284
329
EST
#N/A
#N/A
28.51
25.35
17.97
41.67
43.94
18.29

AA151243
334
EST
#N/A
#N/A
1.13
−0.17
14.55
43.61
42.74
11.08

AA182030
387
EST
8.32
0.00018
14.05
16.82
12.13
222.23
220.01
117.56

AA182568
388
STAT induced STAT inhibitor-2
10.92
0.00099
23.5
18.15
21.15
501.87
386.2
478.02

AA187437
389
EST
#N/A
#N/A
33.59
47.3
26.91
62.23
63
25.01

AA193671
405
KIAA0580 protein
#N/A
#N/A
40.18
43.2
23.51
64.83
38.29
71.28

AA195657
419
EST
6.44
0.00016
5.72
7.44
9.74
157.7
136.21
100.68

AA211370
432
EST
#N/A
#N/A
27.26
29.44
16.5
44.85
45.87
21.25

AA227968
461
histone deacetylase 6
#N/A
#N/A
177.49
137.57
94.86
349.29
340.4
101.81

AA233126
466
EST
#N/A
#N/A
48.86
59.64
33.59
88.56
74.17
35.35

AA233369
471
histidine ammonia-lyase
9.06
0.0008
49.39
47.92
39.8
425.35
405.81
214.85

AA233763
472
EST
4.61
0.00004
25.29
36.26
17.49
146.52
139.66
60.53

AA234717
489
EST
#N/A
#N/A
10.99
5.01
20.04
50.22
53.32
31.32

AA234831
491
EST
3.42
0.00206
23.54
21.62
28.81
112.19
119
49.23

AA242822
524
EST
#N/A
#N/A
9.44
13.66
8.25
27.21
25.96
16.64

AA243654
532
EST
#N/A
#N/A
0.67
3.93
11.08
69.19
62.85
48.63

AA251114
539
prostate cancer overexpressed gene 1
6.6
0.00039
28.47
18.55
28.89
219.81
202.99
87.55

AA251776
545
jun D proto-oncogene
#N/A
#N/A
30.8
23.59
32.23
51.25
46.83
15.96

AA251845
548
EST
#N/A
#N/A
269.35
283.55
60.62
477.47
411.47
377.99

AA253410
564
EST
#N/A
#N/A
18.46
7.23
42.79
49.37
26.82
45.2

AA255546
569
EST
4
0.00301
61.04
67.88
31.64
260.34
224.12
142.84

AA256990
585
EST
#N/A
#N/A
8.43
11.36
27.79
15.63
16.56
6.89

AA258158
588
EST
#N/A
#N/A
7.91
2.43
17.94
44.84
34.32
35.63

AA259064
602
EST
13.15
0.00001
15.32
−1.37
28.67
401.93
394.99
178.23

AA278670
616
EST
#N/A
#N/A
7.44
11.47
12.63
54.24
49.98
28.69

AA278824
619
EST
#N/A
#N/A
26.85
31.59
11.72
83.48
91.25
30.24

AA278853
621
EST
#N/A
#N/A
10.28
11.7
21.49
42.68
43.68
17.64

AA279341
625
EST
#N/A
#N/A
67.56
80.37
50.19
132.89
118.11
67.28

AA281545
645
EST
3.64
0.00002
6.52
−0.81
16.89
87.27
85.27
34.29

AA281770
649
seven in absentia (Drosophila) homolog 1
3.96
0.00094
7.67
4.72
15.41
103.75
79.4
70.74

AA281796
650
mannose-P-dolichol utilitzation defect 1
3.3
0.04108
65.08
53.58
57.86
170.88
165.02
41.87

AA283066
666
EST
#N/A
#N/A
21.18
25.64
13.39
67.44
59.46
35.89

phosphatidylethanolamine N-

AA284795
678
methyltransferase
10.03
0.00019
44.8
62.07
44.12
514.93
591.52
206.4

AA286710
683
lymphocyte adaptor protein
#N/A
#N/A
37.88
39.15
30.32
82.93
86.15
45.58

AA287566
690
KIAA0187 gene product
9.07
0.00013
4.86
6.24
7.4
246.24
201.66
228.64

AA291293
698
EST
#N/A
#N/A
17.35
18.07
17.24
33.6
33.3
5.56

AA342918
750
EST
#N/A
#N/A
23.67
31.68
25.77
69.4
73.71
18.13

AA365691
763
EST
#N/A
#N/A
48.01
47.17
25.37
28.69
26.73
13.89

AA397904
781
EST
#N/A
#N/A
22.74
18.55
19.05
59.75
54.83
32.24

AA398124
787
growth factor receptor-bound protein 14
7.82
0.00009
3.4
5.86
7.61
189.27
167.23
110.44

AA398386
793
EST
5.71
0.00007
10.59
16.25
21.59
153.16
164.38
83.94

AA398423
795
EST
8.26
0.00063
−17.3
−16.19
23.92
230.91
250.5
156.29

AA398674
798
thrombospondin 1
#N/A
#N/A
−27.87
14.49
146.65
137.87
96.14
119.21

calcitonin receptor-like receptor activity

AA400979
825
modifying protein 3
6.65
0.01051
48.89
21.04
80.4
276.38
267.3
88.7

AA401091
826
EST
#N/A
#N/A
31.88
32.59
43.51
30.55
19.82
28.68

growth arrest and DNA-damage-inducible,

AA402224
836
gamma
14.41
0.00012
37.55
48.88
48.58
749.36
812.2
443.66

AA402610
839
KIAA0548 protein
#N/A
#N/A
3.02
6.69
13.83
27.54
23.2
17.78

AA402656
841
EST
12.05
0.00001
−2.56
18.8
40.57
342.11
315.47
205.61

AA404248
847
EST
#N/A
#N/A
11.96
11.18
10.84
40.92
35.06
17.49

AA405495
859
EST
#N/A
#N/A
26.12
22.63
43.42
79
82.8
30.16

AA405744
863
EST
#N/A
#N/A
61.18
28.74
58.71
64.39
57.95
35.67

AA406363
874
EST
#N/A
#N/A
6.85
5.69
15.69
35.62
35.06
13.69

AA406610
880
EST
#N/A
#N/A
5.99
6.04
4.63
35.94
34.84
11.57

AA410255
882
EST
7.56
0.00043
0.82
4.15
11.49
195.75
236.93
110.49

AA411795
892
EST
#N/A
#N/A
72.18
53.17
44.28
130.27
131.65
23.71

AA412063
895
EST
8.26
0.00001
11.36
14.03
19.55
220.12
187.85
149.43

AA412149
897
KIAA0480 gene product
#N/A
#N/A
14.07
10.08
14.16
37.43
32.4
15.56

AA412520
903
EST
#N/A
#N/A
18.84
14.4
14.11
80.29
103.19
41.98

AA412700
904
ubiquitin-conjugating enzyme E2L 6
#N/A
#N/A
139.65
95.44
135.61
275.39
273.98
112.87

AA418398
921
EST
#N/A
#N/A
0.1
−6.02
17.92
30.41
32
20.72

AA421051
928
serum-inducible kinase
#N/A
#N/A
42.94
7.14
87.89
51.27
45.65
28

branched chain alpha-ketoacid

AA421052
929
dehydrogenase kinase
3.52
0.00869
77.76
94.75
43.63
251.45
221.35
109.93

AA425214
950
EST
#N/A
#N/A
2.71
2.07
4.88
21.4
20.31
10.15

AA426643
970
EST
#N/A
#N/A
9.96
0.97
18.11
48.26
47.37
23.47

AA427537
974
DKFZP566J153 protein
#N/A
#N/A
183.26
156.56
68.58
259.57
242.97
79.81

AA427579
975
regulator of G-protein signalling 14
#N/A
#N/A
13.35
13.28
16.49
34.79
25.25
25.11

AA427819
980
midline 2
3.44
0.00063
25.98
17.06
14.91
97.03
93.49
31.39

AA428150
985
EST
5.24
0.00167
41.92
35.06
30.53
213.96
217.27
76.08

AA428325
988
EST
8.36
0.00002
−0.52
3.28
16.92
194.02
167.37
111.11

AA429478
998
EST
3.41
0.02599
55.86
65.19
47.48
192.7
196
89.2

AA435591
1038
kinesin family member 3B
3.5
0.0001
3.57
3.68
10.34
75.9
81.12
29.32

AA436156
1051
EST
#N/A
#N/A
22.66
7.78
34.68
54.98
48.35
38.09

AA436548
1054
EST
#N/A
#N/A
5.08
5.93
5.2
40.27
38.99
22.22

AA436880
1058
EST
3.22
0.00699
4.71
9.21
13.85
86.89
68.41
66.5

AA437295
1062
ribosomal protein L7a
4.35
0.00347
19.67
20.38
43.07
139.16
140.38
70.9

AA443658
1079
transmembrane 7 superfamily member 2
9.06
0.00048
4.48
17.91
24.51
276.02
194.73
227.48

AA447802
1108
EST
#N/A
#N/A
15.64
17.7
13.81
21.51
21.34
7.37

AA449108
1118
EST
#N/A
#N/A
10.9
18.13
15.28
52.58
57.3
23.76

AA449297
1121
EST
3.78
0.00039
3.76
0.63
19.01
91.67
81.15
55.17

AA454667
1167
EST
#N/A
#N/A
21.25
12.77
23.4
83.02
75.81
56.63

heterogeneous nuclear ribonucleoprotein C

AA455111
1173
(C1/C2)
#N/A
#N/A
−31.71
−40.39
38.45
38.96
36.83
26.21

AA455261
1175
chromobox homolog 7
#N/A
#N/A
32.5
45.54
26.51
66.78
66.08
30.15

AA455865
1180
phosphatidylinositol glycan, class B
5.41
0.00004
11.68
8.67
10.65
133.15
134.74
63.3

AA455987
1183
EST
5.36
0.00029
20.54
17.51
15.24
128.55
130.64
17.07

butyrobetaine (gamma), 2-oxoglutarate

dioxygenase (gamma-butyrobetaine

AA455988
1184
hydroxylase)
15.54
0.00001
10.13
11.88
8.38
354.42
375.91
141.08

AA456075
1186
RAD23 (S. cerevisiae) homolog A
#N/A
#N/A
33.34
38.35
32.93
90.47
66.92
66.03

AA456080
1187
EST
#N/A
#N/A
32.35
17.59
33.21
27.76
26.18
12.38

AA456147
1188
general transcription factor IIIA
4.23
0.00088
4.61
0.17
9.08
102.1
89.95
63.84

AA456289
1189
EST
15.31
0.00004
18.07
17.84
39.22
512.64
542.52
303.15

AA456612
1195
EST
#N/A
#N/A
164.11
136.36
117.01
254.26
266.45
84.11

AA458652
1202
EST
8.26
0.00001
19.3
18.21
17.18
203.23
218.67
53.52

AA459005
1210
EST
#N/A
#N/A
−3.57
12.22
40.05
49.76
42.58
28.85

AA461448
1240
EST
#N/A
#N/A
1.74
−4.19
22.52
58.65
56.06
32.42

AA464606
1261
MRS1 protein
#N/A
#N/A
24.35
19.03
39.62
59.55
36.75
57.76

AA465720
1274
EST
#N/A
#N/A
11.5
21.33
37.22
93.06
108.97
43.26

solute carrier family 21 (organic anion

AA470153
1275
transporter), member 9
13.26
0.00315
47.49
48.57
116.54
726.75
713.23
297.62

homolog of mouse quaking QKI (KH domain

AA478104
1296
RNA binding protein)
#N/A
#N/A
−7.07
−11.44
23.2
62.06
47.17
56.07

AA478441
1302
cathepsin F
5.07
0.00752
53.85
67.48
43.52
243.44
243.61
69.17

AA479148
1311
EST
38.05
0
6.2
1.32
14.38
895.91
847.72
362.53

AA479488
1313
S-adenosylhomocysteine hydrolase-like 1
4
0.0269
75.18
60.93
59.8
241.1
222.96
112.87

AA480991
1323
EST
8.59
0.00156
48.08
25.74
51.03
444.29
309.38
367.89

AA487195
1354
EST
#N/A
#N/A
8.73
7.94
9.21
21.04
14.67
16.52

AA487576
1357
EST
#N/A
#N/A
−12.17
−14.87
17.17
26.05
25.27
11.13

AA489009
1366
EST
#N/A
#N/A
15.19
18.01
8.67
59.19
45.15
41.42

AA490964
1384
EST
#N/A
#N/A
20.3
17.53
11.39
47.7
41.84
25.18

AA495803
1392
EST
#N/A
#N/A
95.29
83.46
90.72
94.07
93.85
37.65

AA495924
1395
kinesin family member 3B
#N/A
#N/A
4.16
3.28
2.95
35.69
34.43
19.93

AA496053
1396
EST
3.28
0.00095
5.36
2.22
17.58
81.79
94.01
42.77

AA496936
1403
EST
#N/A
#N/A
17.71
9.86
20.19
30.24
34.4
14.77

AA504324
1412
EST
#N/A
#N/A
45.99
38.81
31.27
74.31
72.05
31.59

AA521290
1421
EST
4.53
0.0148
46.54
22.84
63.63
166.84
174.65
58.28

AA598412
1425
EST
#N/A
#N/A
−2.4
−5.93
29.83
59
52.53
29.41

AA598453
1429
EST
#N/A
#N/A
7.27
7.06
9.67
67.15
54.25
41.65

AA599107
1443
EST
#N/A
#N/A
53.34
10
88.85
77.28
58.08
40.75

AA599214
1446
EST
#N/A
#N/A
10.94
7.36
12.27
34.58
36
14.54

AA608546
1463
EST
12.52
0.00003
−19.59
−29.07
29.39
310.07
300.44
189.6

AA608723
1467
EST
#N/A
#N/A
17.44
15.29
13.31
66.54
70.38
20.94

AA609316
1481
EGF-Iike-domain, multiple 5
7.97
0.00011
22.6
21.61
25.56
236.54
226.79
65.9

AA609519
1482
EST
8.13
0.00009
29.3
22.08
22.59
261.82
243.76
105.33

NOT3 (negative regulator of transcription 3,

AA620965
1511
yeast) homolog
#N/A
#N/A
4.34
8.96
16.51
48.05
40.77
32.06

similar to Caenorhabditis elegans protein

AA621209
1516
C42C1.9
6.34
0.00144
22.77
19.95
46.78
214.61
167.05
138.24

AA621235
1517
EST
3.44
0.0021
26.29
24.68
23.17
114.75
113.36
65.35

D56989
1687
EST
#N/A
#N/A
8.83
6.61
9.79
77.62
55.56
72.14

D59294
1693
EST
#N/A
#N/A
1.31
0.89
6.58
22.83
20.84
14.1

F04611
1792
EST
23.96
0.00018
42.65
18.88
62.74
1011.12
1040.46
589.37

F04677
1794
EST
#N/A
#N/A
138.06
123.28
34.39
355.75
310.97
168.21

F09350
1801
EST
4.79
0.00088
13.91
−6.46
33.97
147.64
130.28
79.24

F09687
1806
EST
#N/A
#N/A
12.72
8.26
28.12
58.85
57.03
31.82

F09729
1807
EST
#N/A
#N/A
9.35
20.58
23.17
55.49
55.78
27.37

F09979
1809
EST
4.36
0.02555
6.98
6.51
20.72
226.47
116.41
288.21

F10149
1810
EST
#N/A
#N/A
111.86
108.46
60.06
257.05
276.87
165.09

F10381
1817
KIAA0541 protein
#N/A
#N/A
22.16
25.03
8.75
64.94
71.82
26.24

F10418
1818
EST
#N/A
#N/A
44.91
44.45
22.72
64.3
52.54
31.96

F13624
1825
breast cancer anti-estrogen resistance 3
#N/A
#N/A
27.76
19.2
32.49
90.8
73.79
59.27

F13782
1827
LIM binding domain 2
4.17
0.00109
−0.64
5.61
22.4
100.8
119.01
55.07

solute carrier family 16 (monocarboxylic acid

H01059
1830
transporters), member 4
#N/A
#N/A
9.13
9.22
13.53
32.73
34.27
21.05

H02855
1832
EST
5.96
0.00458
5.06
1.15
14.13
261.57
93.25
407.93

H05970
1849
EST
#N/A
#N/A
9.16
12.81
14.19
68.16
65.08
40.19

H09331
1865
EST
#N/A
#N/A
313.2
309.79
122.67
512.04
486.42
149.27

H09353
1866
EST
23.06
0.00094
45.11
18.95
65.29
782.6
824.74
226.28

H10661
1871
EST
4.54
0.00276
31.29
18.75
28.5
132.09
124.86
64.37

H12593
1880
zinc-finger protein 265
10.72
0.0056
39.96
−9.15
111.74
515.58
506.07
224.5

H19504
1895
EST
3.13
0.04948
77.07
49.48
64.05
227.6
221.91
125.23

H20543
1897
DKFZP586B1621 protein
31.03
0.00074
62.11
36.98
80.24
1684.92
1680.81
731.79

H24081
1901
KIAA1035 protein
#N/A
#N/A
19.72
18.46
5.69
24.15
27.08
9.52

H25124
1903
EST
3.65
0.00004
20.47
14.4
12.59
95.09
85.36
34.91

H29568
1914
EST
11.45
0.00058
232.54
140.09
218.85
2206.49
1884.76
783.84

H30270
1915
EST
17.09
0.00001
61.64
60.29
25.01
1224.59
1332.66
695.76

ATP-binding cassette, sub-family C

H49417
1939
(CFTR/MRP), member 6
#N/A
#N/A
16.93
17.31
8.56
62.68
54.75
48.37

H52251
1942
EST
#N/A
#N/A
25.41
22.3
15.29
33.86
34.48
19.95

H53829
1946
EST
#N/A
#N/A
44.31
40.52
36.62
99.9
98.22
46.1

H56965
1952
EST
#N/A
#N/A
0.18
0.68
12.9
61.03
73.89
30.12

protein phosphatase 2 (formerly 2A),

H57850
1958
regulatory subunit A (PR 65), beta isoform
3.02
0.00123
41.36
36.05
15.14
131.12
130.36
53.67

H58692
1960
formyltetrahydrofolate dehydrogenase
81.41
0
−2.66
5.46
16.1
1886.69
1520.43
1129.35

H60317
1965
EST
#N/A
#N/A
18.86
22.34
11.81
38.92
39.1
18.67

H69565
1987
EST
4.11
0.00002
15.45
16.92
9.4
95.6
94.91
42.92

H70485
1988
EST
#N/A
#N/A
113.44
81.62
63.73
232.9
256.86
107.1

H70554
1989
EST
10.99
0
−11.73
−19.98
33.09
292.66
288.78
153.17

H87765
2017
KIAA0626 gene product
3.86
0.00131
5.2
7.91
19.6
94.26
93.78
60.64

protein phosphatase 1, regulatory (inhibitor)

H89980
2026
subunit 5
31.13
0.00006
12.16
13.82
12.3
990.48
1005.21
755.6

H90417
2028
EST
4.17
0.015
14.23
−10.79
70.02
191.04
154.37
125.5

H93381
2036
EST
24.23
0
6.08
−0.69
28.81
621.48
640.77
214.25

H95079
2046
EST
#N/A
#N/A
7.05
11.03
7.33
39.79
33.3
29.08

H95089
2047
EST
#N/A
#N/A
13.05
13.54
4.03
31.99
31.89
13.19

H95358
2049
EST
3.17
0.00182
−5.85
−5.95
11.57
74.74
72.66
42.36

H95978
2052
EST
8.55
0.00046
12.28
14.38
10.71
240.91
246.43
147.67

H98083
2067
EST
5.09
0.00025
11.73
11.11
3.97
121.51
104.88
70.52

N22404
2449
EST
3.99
0.01152
30.59
23.97
55.32
193.63
130.09
162.83

N22434
2450
EST
4.37
0.01725
100.96
66.55
110.62
334.51
328.98
150.7

N24879
2459
EST
9.44
0.00008
6.2
5.49
23.52
280.93
337.77
165.77

N24973
2461
EST
#N/A
#N/A
30.46
28.45
11.29
56.57
59.09
22.87

N25262
2464
EST
#N/A
#N/A
31.16
28.04
9.03
64.13
64.97
18.29

N27524
2471
EST
3.13
0.00216
14.18
22.08
20.51
87.67
98.26
42.62

kynurenine 3-monooxygenase (kynurenine 3-

N29353
2476
hydroxylase)
4.78
0.00019
−4.7
−5.88
13.94
109.79
101.27
53.38

N29543
2478
EST
#N/A
#N/A
11.66
9.07
5.04
59.21
51.22
30.43

N29740
2479
EST
#N/A
#N/A
48.71
27.45
46.9
80.01
77.9
37.18

N31952
2489
EST
3.13
0.01481
36.21
27.5
25.04
133.49
147.66
83.03

N34804
2496
DKFZP434J214 protein
8.08
0.00028
6.99
5.94
33.73
344.08
176.4
532.11

N34919
2498
EST
#N/A
#N/A
7.39
8
6.82
52.96
44.23
24.23

N36085
2504
EST
#N/A
#N/A
20.98
19.21
13.89
58.28
58
22.95

N45320
2518
EST
#N/A
#N/A
11.39
11.26
7.06
50.75
36
39.19

N45998
2519
EST
3.14
0.00337
28.42
22.62
13.52
99.42
110.53
49.55

adaptor-related protein complex 2, mu 1

N48315
2526
subunit
5.3
0.0149
62.03
30.66
52.29
368.37
331.28
260.93

N48674
2529
EST
4.06
0.00028
2.7
4.57
10.52
94.61
72.82
54.62

N50038
2540
EST
#N/A
#N/A
0.25
5.19
45.95
47.04
41.45
16.56

N54053
2560
secreted phosphoprotein 2, 24kD
60.39
0.00087
44.3
−18.16
166.47
2749.73
2790.77
1230.33

N54604
2569
EST
3.72
0.00741
2.36
2.08
35.23
133.06
119.1
109.95

cytidine monophosphate-N-acetylneuraminic

acid hydroxylase (CMP-N-acetylneuraminate

N54792
2570
monooxygenase)
3.23
0.00099
28.36
27.42
6.39
110.19
77.69
87.32

N59089
2580
EST
4.74
0.00055
38.4
36.58
24.6
215.54
167.6
133.64

N59543
2586
PDZ domain containing 1
9.96
0.00052
1.2
−2.89
17.29
303.49
259.23
225.96

N62922
2595
EST
#N/A
#N/A
14.92
14.15
2.75
54.94
52.4
18.93

N63047
2596
EST
#N/A
#N/A
4.13
0.93
9.72
14.78
15.63
8.24

N63698
2603
EST
7.92
0.00001
19.14
18.14
12.14
221.25
212.4
122.32

N64436
2608
EST
3.51
0.00441
24.46
20.38
21.08
119.24
133.44
70.66

N65959
2611
EST
5.43
0.00044
3.51
3.25
22.24
142.87
149.26
79.26

N66613
2616
EST
#N/A
#N/A
25.61
22.34
26.39
62.58
50.13
51.99

N68871
2637
EST
#N/A
#N/A
4.3
4.02
8.66
34.08
36.71
14.33

N70305
2654
EST
4.41
0.00078
−13.99
−13.48
10.76
105.8
97.72
72.15

N71542
2664
kidney- and liver-specific gene
21.05
0
−14.76
−18.28
14.3
471.65
486.43
226.63

N71935
2666
multiple PDZ domain protein
16.28
0
12.84
19.17
14.1
410.92
422.1
218.42

N73883
2681
EST
9.35
0
18.47
23.48
17.67
256.78
276.41
95.34

N74025
2684
deiodinase, odothyronine, type I
22.79
0
−7.64
2.14
15.95
527.67
515.68
256.99

N74422
2685
EST
30.32
0
23.57
28.41
36.93
1063.07
1094.48
371.26

collectin sub-family member 10 (C-type

N74624
2687
lectin)
#N/A
#N/A
33.8
34.24
5.13
71.81
62.09
43.57

N75072
2688
EST
3.73
0.00379
5.14
6.21
15.5
104.12
104.99
81.79

N76086
2694
EST
#N/A
#N/A
8.23
7.19
6.54
55.55
55.02
35.47

N91882
2719
alpha2,3-sialyltransferase
14.52
0.00024
−0.18
0.18
34.36
512.3
550.51
320.62

N93191
2729
EST
3.25
0.00232
174.54
168.53
56.36
659.95
565.08
409.15

N93403
2733
EST
#N/A
#N/A
4.44
7.63
11.8
48.84
38.39
30.93

N93764
2736
EST
5.92
0.0109
113.46
68.13
96.98
771.74
792.59
504.88

SEC24 (S. cerevisiae) related gene family,

R05490
2760
member B
3.03
0.00317
5.87
3.49
12.23
75.28
78.17
48.59

R06002
2762
EST
10.15
0.00003
10.52
8.26
20.8
292.89
264.17
160.28

R06543
2768
EST
#N/A
#N/A
61.75
61.42
88.77
163.57
144.04
96.98

R06746
2770
EST
15.77
0.00009
13.37
−0.9
39.24
455.48
410.16
191.35

R06860
2772
EST
#N/A
#N/A
84.61
75.89
71.35
104.51
116.59
44.71

R08564
2779
plasminogen-like
60.18
0.00091
69.78
24
105.91
2485.63
2384.62
531.43

R09053
2782
EST
5.9
0.0002
6.45
17.17
35.01
186.87
204.61
113.19

R10287
2784
EST
11.2
0.0003
7.46
4.94
35.03
376.82
434.91
198.74

R10684
2787
EST
5.51
0.00741
28.67
1.31
62.39
217.05
221.32
122.94

R12472
2788
EST
55.18
0.00011
32.21
3.13
76.26
2002.79
1930.03
1097.37

R12579
2789
EST
3.5
0.00137
54.49
37.84
26.65
198.7
194.59
92.03

R33146
2818
EST
7
0.00043
3.32
2.1
10.76
179.67
195.02
107

R34362
2821
KIAA0327 gene product
5.4
0.04615
621.7
353.73
689.66
2107.55
2121.04
1000.75

R39238
2835
synaptojanin 1
#N/A
#N/A
16.06
16.03
9.94
26.8
23.84
16.46

R43347
2848
downregulated in renal cell carcinoma
#N/A
#N/A
36.93
32.68
30.41
105.66
100.62
28.62

R43365
2849
EST
5.37
0.00103
5.57
6.67
12.18
150.58
112.8
122.96

R43910
2851
EST
5.71
0
23.41
24.6
11.1
156.7
166.34
52.21

R49602
2884
EST
36.5
0.00001
19.25
9.65
26.41
970.39
905.54
322.69

R51831
2890
EST
5.03
0.00761
5.89
2.5
44.67
221.54
195.97
179.99

R52822
2895
EST
12.79
0.00001
10.78
0.35
28.51
380.07
441.17
180.12

R53044
2897
KIAA0981 protein
#N/A
#N/A
17.84
25.74
11.45
48.77
44.34
18.43

R53891
2899
EST
#N/A
#N/A
9.88
5.59
10.68
66.28
52.16
49.21

R59312
2912
EST
#N/A
#N/A
34.37
35.83
22.13
94.44
91.55
36.35

R59722
2915
EST
19.74
0.00016
18.78
−4.94
51.34
628.69
642.78
316.88

R60959
2918
EST
#N/A
#N/A
31.21
23.86
17.79
72.94
69.87
45.25

R63734
2927
fatty-acid-Coenzyme A ligase, long-chain 3
#N/A
#N/A
13.28
17.42
12.17
42.74
39.66
18.51

kynurenine 3-monooxygenase (kynurenine 3-

R65593
2934
hydroxylase)
21.27
0.00007
28.84
18.5
43.46
704.58
812.38
352.86

R70319
2945
EST
#N/A
#N/A
5.34
2.91
8.92
29.23
29.18
10.78

R70791
2948
EST
#N/A
#N/A
127.11
110.15
41.83
73.19
57.2
56.17

R73468
2956
EST
#N/A
#N/A
9.97
10.43
9.69
38.29
44.82
17.14

R73816
2960
EST
11.53
0.00259
−26.88
−30.68
10.09
462.31
374.67
450.91

R78713
2967
EST
#N/A
#N/A
0.27
−1.59
8.92
70.57
57.33
56.37

R91060
2980
EST
#N/A
#N/A
59.14
37.15
56.04
85.88
61.99
68.99

R93507
2990
EST
#N/A
#N/A
19.53
20.08
11
67.62
67.56
44.22

R93714
2991
fetuin B
10.42
0.00043
−60.74
−65.14
57.99
280.62
301.36
203.86

R93908
2993
EST
5.8
0.02699
66.75
29.54
129.46
348.58
301.29
173.81

R94674
2995
EST
10.76
0.00008
0.91
4.15
14.66
269.49
288.56
148.06

R96822
2999
EST
8.25
0.00008
16.45
17.01
30.67
250.81
257.18
131.85

cytochrome P450, subfamily VIIIB (sterol 12-

R97419
3003
alpha-hydroxylase), polypeptide 1
65.07
0.0039
152.16
−3.42
302.56
4114.39
3837.4
1458.43

R97804
3007
EST
#N/A
#N/A
144.46
187.67
95.8
193.05
201.89
61.84

R98413
3011
EST
9.71
0.00007
38.74
28.05
21.96
402.49
443.47
212.95

R99014
3014
EST
#N/A
#N/A
26.99
17.82
29.49
49.82
52.35
18

T16306
3067
EST
#N/A
#N/A
24.23
23.64
24.91
58.82
63.62
22.35

protein tyrosine phosphatase type IVA,

T40895
3116
member 1
#N/A
#N/A
1575.59
2039.82
1098.29
4148.86
2440.28
4169.52

T46901
3122
EST
77.28
0.0006
11.33
−31.1
121.66
2608.54
2853.98
691.43

T50773
3135
apolipoprotein C-lV
#N/A
#N/A
94.77
43.61
169.6
8473.97
6484.47
7036.85

T58756
3155
EST
13.39
0.00013
7.38
−19.91
46.26
390.04
386.76
164.41

small inducible cytokine subfamily A (Cys-

T58775
3156
Cys), member 16
21.18
0.00006
11.93
−0.59
34.83
577.14
540.96
205.27

T67520
3181
EST
#N/A
#N/A
52.46
49.25
28.02
105.56
113.95
38.23

T67931
3183
fibrinogen, B beta polypeptide
49.55
0
−22.74
−22.4
23.54
1187.95
1000.67
692.18

T69305
3196
EST
#N/A
#N/A
−107.09
−119.3
45.51
4052.6
4262.37
3025.26

T71978
3204
EST
4.39
0.0017
41.46
58.86
43.93
218.38
208.73
89.39

T72502
3207
EST
8.87
0.00009
24.11
24.41
28.19
308.87
271.27
179.15

T73442
3212
EST
94.41
0
28.55
25.96
25.95
3170.29
3275.73
1073.74

T74608
3215
hydroxyacid oxidase (glycolate oxidase) 1
14.03
0
−3.14
−1.78
23.12
360.97
328.7
194.85

T82323
3230
immunoglobulin superfamily, member 4
10.14
0
14.47
5.07
19.91
264.33
229.92
135.46

T87224
3240
EST
#N/A
#N/A
584.24
451.54
184.49
909.33
851.86
431.47

T90037
3245
EST
3.99
0.0016
23.17
25.82
23.62
150.67
107.18
126.19

T90520
3248
EST
8.67
0.00072
9.05
−7.07
25.65
306.39
362.5
204.34

W15417
3472
KIAA0699 protein
#N/A
#N/A
30.82
20.85
38.03
83.24
81.29
49.83

W48860
3534
EST
#N/A
#N/A
36.89
39
14.08
52.69
41.31
21.1

W60186
3554
EST
3.24
0.00228
19.15
26.5
27.35
101.92
109.68
47.85

W63741
3563
EST
#N/A
#N/A
−11.85
−13.73
14.25
28.54
17.1
44.58

W67147
3565
deleted in liver cancer 1
9.74
0.00002
16.09
9.11
24.66
282.59
235.29
169.33

W67199
3566
EST
3.09
0.01528
30.05
35
12.16
123.27
117.99
90.47

oxidative 3 alpha hydroxysteroid

W72382
3581
dehydrogenase; retinal dehydrogenase
#N/A
#N/A
37.21
6.21
66.91
3403.46
3255.54
1538.23

W72471
3582
EST
#N/A
#N/A
17.93
13.32
10.61
71.51
76.9
29.33

W85765
3615
EST
3.83
0.00379
3.6
1.46
7.87
108.99
77.01
109.58

W85886
3618
EST
3.46
0.00814
−6.09
−2.4
11.46
99.92
68.44
97.4

protein C inhibitor (plasminogen activator

W86431
3624
inhibitor III)
14.94
0.00152
3.16
5.55
12.03
606.44
395.34
590.7

W86600
3625
EST
32.14
0
12.67
7.49
15.61
792.37
807.74
313.83

W88946
3636
putative glycine-N-acyltransferase
58.26
0
2.16
−22.13
39.9
1717.54
1821.77
502.55

W90018
3639
EST
#N/A
#N/A
−2.1
4.12
13.16
59.32
53.19
41.68

W90396
3642
EST
#N/A
#N/A
16.1
15.26
11.11
23.65
22.93
10.28

W94942
3658
dual specificity phosphatase 10
7.23
0.00137
19.36
16.05
11.9
250.16
281.49
160.43

W95041
3659
EST
12.79
0.00001
6.66
5.17
3.55
291.2
298.05
115.81

Z38161
3881
EST
4.38
0.0011
11.84
12.14
6.32
111.16
107.62
80.11

Z38910
3895
EST
#N/A
#N/A
0.68
2.75
12.7
35.49
32.21
23.55

Z39394
3901
EST
#N/A
#N/A
10.11
10.43
11.1
24.06
22.96
11.11

Z39622
3907
EST
4.4
0.00001
19.65
21.87
11.97
110.87
115.21
36.19

Z39976
3912
EST
5.76
0.00012
13.09
7.15
18.64
165.45
151.05
98.9

Z40259
3916
EST
8.18
0.00002
14.39
8.61
11.98
218.4
223.24
122.06

Z41271
3927
ariadne, Drosophila, homolog of
#N/A
#N/A
51.96
64.49
36.28
145.09
126.18
57.57

Z41634
3931
EST
#N/A
#N/A
16.4
16.07
3
51.19
48.49
33

AA001902
5
KIAA0305 gene product
#N/A
#N/A
14.88
17.06
8.8
29.11
28.6
23.36

AA001903
6
EST
#N/A
#N/A
6.64
0.97
14.07
26.52
28.7
13.21

AA004669
9
EST
#N/A
#N/A
8.66
10.77
8.65
33.32
25.36
31.12

AA009719
20
peroxisomal membrane protein 2 (22kD)
47.12
0.00008
−50.14
−51.69
47.17
1370.32
1503.99
715.62

AA010205
23
EST
7.41
0
14.43
17.64
14.87
187.55
154.99
92.13

AA010360
24
EST
6.55
0.00027
12.5
14.77
8.62
169.99
135.98
129.2

potassium voltage-gated channel, shaker-

AA013095
33
related subfamily, beta member 1,
#N/A
#N/A
7.81
3.06
19.71
18.56
15.83
8.24

AA015768
34
EST
15.3
0.00008
12.22
14.2
11.71
417.95
472.1
248.15

AA016021
35
ubiquitin-like 3
#N/A
#N/A
13.88
16.21
13.21
65.65
51.44
46.44

AA018867
39
EST
42.87
0.00002
45.29
29.28
52.68
1944.56
2160.33
1142.41

AA024511
46
suppressor of Ty (S.cerevisiae) 3 homolog
#N/A
#N/A
7.82
3.08
12.06
62.54
58.34
27.73

AA031360
67
EST
#N/A
#N/A
13.46
12.87
10.49
26.25
24.36
9.3

AA034365
76
EST
#N/A
#N/A
119.5
39.46
171.27
216.28
159.86
152.39

AA039616
90
EST
9.36
0.00009
2.48
−4.83
14.2
238.71
224.42
125.28

AA040087
92
EST
4.13
0.00123
34.99
27.32
18.99
156.63
148.88
90.44

AA040291
94
KIAA0669 gene product
3.55
0.00308
12.98
12.72
16.36
101.69
98.94
80.43

AA046457
111
EST
3.2
0.00513
77.66
80.71
27.66
304.54
264.9
233.62

AA056482
141
EST
4.82
0.00199
10.09
19.17
14.96
135.83
132.94
97.88

macrophage receptor with collagenous

AA074885
161
structure
11.05
0.00786
79.55
25.58
153.64
652.03
761.74
300.57

AA075298
163
EST
#N/A
#N/A
46.45
36.93
42.61
129.13
121.57
70.36

AA086201
185
EST
5.8
0.00012
21.29
24.75
14.37
177.39
182.95
95.51

AA099225
206
EST
7.33
0.00062
4.37
1.35
6.08
212.68
163.45
194.31

AA099571
209
MD-2 protein
#N/A
#N/A
10.12
4.61
19.11
55.77
62.72
31.71

AA115933
231
KIAA1098 protein
#N/A
#N/A
8.62
6.46
10.77
33.88
34.38
16.63

AA126059
246
EST
3.08
0.00706
102.34
104.33
40.8
380.92
280.71
316.4

AA127514
253
EST
3.4
0.00045
11.36
10.76
6.8
74.71
76.5
36.07

AA127646
254
schwannomin interacting protein 1
#N/A
#N/A
6.76
−0.26
12.36
44.24
41.48
20.02

AA129465
263
EST
#N/A
#N/A
7.9
10.16
24.29
61.62
59.75
34.37

meningioma expressed antigen 6 (coiled-coil

AA133214
276
proline-rich)
#N/A
#N/A
3.16
7.46
14.35
65.17
56.11
51.18

AA133457
280
EST
#N/A
#N/A
233.92
279.32
161.44
456.09
475.45
114

AA136333
300
zinc finger protein
#N/A
#N/A
17.23
17.21
5.7
45.55
39.88
25.1

AA167550
361
EST
#N/A
#N/A
4.38
7.64
6.98
28.69
26.29
16.06

AA171529
365
EST
#N/A
#N/A
−1.76
−4.58
6.37
51.3
47.89
33.98

AA179004
377
EST
14.34
0.00008
−33.2
−28.97
78.62
503.76
495.87
326.16

protein phosphatase 2 (formerly 2A),

AA191310
397
regulatory subunitA (PR 65), beta isoform
7.28
0
26.23
29.87
6.93
206.65
209.15
77.34

AA195463
416
EST
#N/A
#N/A
5.44
6.92
3.77
51.81
64.76
26.85

AA195515
417
EST
#N/A
#N/A
7.27
3.56
8.61
51.59
49.91
23.13

intercellular adhesion molecule 1 (CD54),

AA197311
422
human rhinovirus receptor
6.07
0.00053
−19.49
1.63
43.72
154.69
175.76
83.19

AA199603
423
EST
#N/A
#N/A
14.97
24.27
28.57
54.95
55.7
19.61

AA223902
450
EST
9.91
0.00003
7.98
−3.32
28.42
292.86
294.78
156.98

AA226925
452
EST
#N/A
#N/A
11.94
9.22
7.55
49.69
48.29
27.49

AA232114
463
epoxide hydrolase 2, cytoplasmic
24.34
0.00007
63.09
46.66
60.38
1455.28
1626.11
664.36

AA233152
467
EST
12.95
0
−29.09
−28.01
34.42
299.54
291.48
156.26

AA233797
473
sperm associated antigen 7
#N/A
#N/A
54.72
50.23
11.36
116.14
127.3
54.24

AA233837
474
EST
4.79
0.0034
18.96
19.45
40.67
214.77
118.28
278.62

AA235288
494
PTPL1-associated RhoGAP 1
3.7
0.00643
34.06
30.95
14.36
169.9
113.81
138.05

AA250958
538
EST
#N/A
#N/A
53.41
53.63
22.55
99.74
114.71
55.23

AA255903
573
CD39-like 4
5.67
0.01687
72.5
39.23
108.92
383.56
374.1
211.92

AA256341
578
EST
7.37
0.00091
17.81
2.34
28.59
280.57
324.08
170.98

M279916
633
EST
#N/A
#N/A
61.08
56.18
25.7
115.24
102.89
58.77

spleen focus forming virus (SFFV) proviral

AA280413
638
integration oncogene spi1
4.46
0.02062
64.05
69.15
51.55
339.15
353.53
235.59

AA282541
661
EST
#N/A
#N/A
7.18
5.97
14.25
31.31
29.9
13.53

AA343142
751
EST
20.87
0.00003
−12.34
−21.46
30.45
610.64
636.83
438.33

AA397919
785
EST
#N/A
#N/A
108.63
144.35
84.25
243.79
199.62
185.4

AA398280
792
EST
12.43
0.00134
−114.74
−71.05
103.33
433.45
423.73
356.61

AA404352
850
EST
7
0.00059
26.7
20.02
33.28
213.01
172.11
108

AA406546
879
EST
#N/A
#N/A
−1.45
−7.89
15.19
46.62
50.65
26.97

5-methyltetrahydrofolate-homocysteine

AA416936
910
methyltransferase reductase
4.98
0.00632
82.04
85.81
69.18
427.41
366.53
235.63

AA424798
947
EST
17.45
0.00352
48.63
15.48
171.26
879.91
873.25
489.59

AA428900
992
EST
7.01
0.00037
66.25
66.77
15.35
615.96
619.42
441.72

AA429038
995
EST
3.29
0.00927
13.39
1.93
28.01
108.66
87.59
86.11

AA434225
1035
serum constituent protein
#N/A
#N/A
1010.84
876.42
674.94
1022.5
746.49
681.49

AA463729
1250
EST
4.07
0.00676
19.31
19.05
13.37
150.62
116.86
156.67

AA479961
1320
EST
#N/A
#N/A
33.49
28.45
10.58
88.13
89.35
36.9

AA490947
1383
EST
#N/A
#N/A
34.15
35
21.49
56.24
38.75
49.85

AA599199
1444
endothelin converting enzyme 1
#N/A
#N/A
187.77
108.97
225.55
695.29
680.26
375.12

catenin (cadherin-associated protein), alpha-

AA621315
1521
like 1
#N/A
#N/A
191.28
141.04
182.69
313.23
281.93
134.57

aldehyde dehydrogenase 5 family, member

C20982
1582
A1 (succinate-semialdehyde dehydrogenase)
#N/A
#N/A
68.8
85.38
28.73
104.44
88.12
66.28

C21130
1583
EST
8.79
0.00008
17.56
8.6
19.19
277.18
238.8
188.55

low density lipoprotein receptor (familial

D11835
1598
hypercholesterolemia)
21.76
0.00307
76.38
23.21
131.25
895.7
910.39
322.98

D45714
1664
EST
5.64
0.00384
34.3
29.86
13.09
301.07
218.14
282.7

F04944
1795
acyl-Coenzyme A oxidase
4.01
0.00242
40.92
33.99
28.07
191.04
192.25
99.98

F10276
1814
dual specificity phosphatase 6
8.13
0.0001
19.64
13.06
12.33
240.65
275.65
138.17

glycine dehydrogenase (decarboxylating;

glycine decarboxylase, glycine cleavage

H11739
1876
system protein P)
10.33
0.00023
−21.2
−37.69
28.32
290.05
210.37
244.67

H68239
1983
EST
#N/A
#N/A
26.96
17.94
15.81
66.76
66.18
51.67

H79820
2004
EST
3.25
0.01466
10.64
2
22.28
113.3
113.19
95.96

H82966
2011
apolipoprotein B (including Ag(x) antigen)
3.42
0.00769
0.2
1
15.26
100.93
77.36
96.78

H96392
2053
EST
#N/A
#N/A
12.6
9.93
33.15
35.98
53.46
42.74

N22938
2452
serum amyloid A4, constitutive
35.39
0.00128
163.4
145.31
160.24
4244.44
3330.35
2358.25

N32071
2490
EST
8.75
0.00006
40.89
43.12
15.37
421.21
488.49
238.4

N47469
2521
EST
3.34
0.00329
20.35
13.91
20.65
104.74
99.87
61.84

N48155
2524
EST
#N/A
#N/A
17.08
16.77
14.66
97.37
54.69
99.7

N51117
2543
EST
9.68
0.00081
8.23
4.5
11.88
327.53
296.4
266.42

N52845
2553
EST
5.53
0.00088
28.56
30.14
14.95
219.38
230.31
149.67

N53757
2559
EST
3.97
0.00255
99.49
80.7
56.09
365.45
324.21
118.42

N55272
2573
EST
#N/A
#N/A
22.71
13.6
24.4
45.08
47.45
14.77

N59550
2587
EST
25.56
0.00024
19.9
2.53
65.91
855.88
774.72
358.3

N64017
2605
EST
5.27
0.00022
5.45
8.71
8.71
122.34
135.27
55.58

activating transcription factor 4 (tax-

N67974
2629
responsive enhancer element B67)
#N/A
#N/A
5.67
−0.08
15.97
82.1
74.13
59.47

N70358
2656
growth hormone receptor
34.35
0
20.93
29.26
36.06
1449.57
1157.97
1115.22

N73561
2675
EST
12.96
0.00011
17.04
4.48
25.06
516.79
458.57
393.69

N80129
2702
metallothionein 1L
66.48
0.00415
179.8
104.5
643.06
10421.47
6358.88
9618.38

N93470
2735
EST
#N/A
#N/A
14.01
8.69
17.09
77.86
66.84
70.45

glucose-6-phosphatase, catalytic (glycogen

R02365
2754
storage disease type I, von Gierke disease)
17.17
0.00124
0.92
−5.3
9.39
768.72
444.03
841.02

glucokinase (hexokinase 4) regulatory

R06977
2774
protein
6.1
0.00049
−47.7
−38.97
37.79
152.22
150.69
87.15

R43174
2847
paraoxonase 1
74.04
0.00038
47.94
−8.83
119.68
2926.85
3104.07
1318.41

R67970
2939
gamma-glutamyl carboxylase
9.45
0.00212
85.44
59.33
76.67
655.11
692.66
267.95

R98105
3010
EST
#N/A
#N/A
132.16
97.16
141.15
373.83
342.91
215.89

R98624
3012
EST
21.32
0
15.01
4.48
22.97
686.81
542.22
466.97

CD5 antigen-like (scavenger receptor

R99591
3015
cysteine rich family)
9.52
0.00006
87.08
72.59
28.25
1035.39
904.92
691.83

T48075
3129
hemoglobin, alpha 1
32.56
0.00172
246.19
164.89
271.65
7193.85
5199.28
6317.01

solute carrier family 22 (extraneuronal

T51617
3137
monoamine transporter), member 3
17.67
0.00018
29.08
19.44
56.17
669.34
725.25
402.58

T51930
3138
EST
9.99
0.00066
8.27
9.41
5.97
325.48
218.59
298.12

T67705
3182
asialoglycoprotein receptor 2
31.6
0.00705
168.64
37.91
284.26
2403.76
2437.4
683.22

T68711
3187
EST
37.65
0.00036
19.73
−26.69
95.05
1388.67
1074.67
890.91

mannose-binding lectin (protein C) 2, soluble

T69284
3195
(opsonic defect)
36.53
0
9.82
0.32
17.14
1147.2
618.07
972.57

T72171
3205
thyroxin-binding globulin
10.41
0.00163
5.48
−20.52
54.58
492.89
371.71
454.89

T72906
3209
EST
7.56
0.00062
4.88
3.04
14.04
233.73
199.26
211.99

alanine-glyoxylate aminotransferase

(oxalosis I; hyperoxaluria I; glycolicaciduria;

T73739
3213
serine-pyruvate aminotransferase)
16.18
0.00277
1891.22
896.45
2229.6
26094.38
15281.08
25947.4

W42429
3506
EST
#N/A
#N/A
98.32
80.07
52.23
252.63
300.68
162.35

W58756
3551
EST
12.17
0.00087
93.37
88.97
71.48
1363.71
1064.26
1032.27

W70131
3574
EST
#N/A
#N/A
108.21
30.68
183.05
118.49
100.66
53.4

W72044
3577
insulin induced gene 1
24.58
0.00001
41.6
36.28
36.46
1133.09
940.16
723.6

W72079
3578
EST
6.36
0.00641
46.78
17.94
66.71
261.7
214.62
175.87

W72972
3584
EST
5.61
0.00939
44.7
26.44
80.59
277.4
270.63
183.07

W73382
3588
EST
#N/A
#N/A
62.97
39.05
67.26
87.32
89.49
28.17

W85847
3616
EST
7.28
0.00024
4.15
5.29
9.26
187.31
160.02
130.73

homogentisate 1,2-dioxygenase

W87454
3629
(homogentisate oxidase)
7.93
0.00149
11.36
5.83
39.02
336.07
275.03
315.24

W92148
3647
kininogen
51.09
0.00376
220.31
42.96
427.59
3697.54
4015.04
1444.99

Z41356
3929
EST
#N/A
#N/A
4.46
15.94
28.44
82.7
48.14
71.73

acyl-Coenzyme A dehydrogenase, long

AA112209
223
chain
3.37
0.00084
29.77
28.31
11.33
116
100.18
66.07

AA149253
323
EST
5.12
0.00863
78.65
75.3
61.14
401.77
301.06
333.03

AA211418
434
EST
#N/A
#N/A
65.81
70.1
37.84
223.56
214.42
151.4

AA227480
456
pim-2 oncogene
3.31
0.02413
48
62.07
33.49
195.79
162.34
182.76

AA235507
498
golgi autoantigen, golgin subfamily a, 5
3.28
0.00249
22.14
37.31
26.61
111.91
126.75
58.39

AA257057
586
EST
8.11
0.00379
42.36
16.78
47.02
451.86
462.6
343.05

AA258353
593
EST
5.28
0.00193
71.76
84
37.77
347.7
363.14
106.2

AA279158
623
EST
#N/A
#N/A
50
46.97
19.41
87.9
72.44
38.36

AA282956
664
EST
#N/A
#N/A
0.28
−9.07
30.81
59.89
51.54
35.5

AA285053
681
EST
6.95
0.00125
12.65
14.54
23.53
238.16
242.27
169.12

AA312946
731
EST
9.21
0.00106
12.32
13.78
12.24
300.22
304.56
213.18

complement component 8, gamma

AA344866
752
polypeptide
7.28
0.00206
292.65
305.28
176.61
1845.16
1679.29
561.04

AA363203
761
EST
#N/A
#N/A
35.7
40.27
34.51
78.45
75.11
47.8

AA381125
772
EST
15.48
0
17.66
13.82
13.2
412.26
344.45
217.56

AA400030
806
EST
3.98
0.00088
8.99
12.21
11.35
97.83
115.15
52.04

AA400080
807
EST
#N/A
#N/A
25.33
23.57
27.54
61.21
60.21
29.91

AA400258
812
EST
11.89
0.00478
85.31
36.81
139.93
827.48
884.35
562.14

AA400934
824
EST
4.98
0.02013
75.44
67.21
77.7
305.09
307.45
125.76

AA401562
830
EST
50.45
0.00301
155.46
63.87
317.6
3745.71
3628.4
1635.98

AA401825
831
EST
#N/A
#N/A
24.3
26.82
18.04
65.22
57.51
46.54

AA405494
858
EST
#N/A
#N/A
10.03
9.53
7.62
59.95
44.88
50.8

AA412068
896
EST
#N/A
#N/A
30.52
29.79
13.4
81.26
74.52
35.68

AA417078
916
EST
4.1
0.00414
36.75
35.35
15.12
189.88
171.1
150.02

AA419608
925
EST
9.19
0.00005
51.89
51.37
25.93
524.34
571.05
296.46

AA419622
926
EST
4.62
0.00386
24.88
17.15
26
158.88
162.5
112.57

AA421561
933
insulin-like growth factor 2 (somatomedin A)
9.98
0.00007
79.46
77.34
41.63
921.91
703.16
679.72

AA429651
1002
KIAA0871 protein
#N/A
#N/A
15.52
13.25
17.03
44.75
41.91
28.67

succinate dehydrogenase complex, subunit

AA432166
1030
C, integral membrane protein, I5kD
#N/A
#N/A
10.94
14.1
42.99
33.86
42.75
27.46

AA435753
1045
EST
4.71
0.00078
198.97
193.33
110.58
970.79
830.39
567.79

AA443934
1083
GTP-binding protein Rho7
3.09
0.00214
30.32
35.97
13.76
115.87
113.7
66.78

AA446342
1088
seven in absentia (Drosophila) homolog 1
4.84
0.00015
9.92
9.12
4.58
110.73
115.89
53.13

FXYD domain-containing ion transport

AA448300
1116
regulator 1 (phospholemman) 24.97
0.00001
118.64
81.63
70.34
2849.54
2905.51
994.41

AA452158
1141
ras homolog gene family, member B
28.96
0.00064
−103.87
−106.99
71.68
1071.9
1164.8
789.64

AA453770
1157
EST
6.04
0.00524
46.33
25.95
53.45
217.46
212.4
70.02

AA454177
1164
EST
10.3
0.0008
9.16
14.72
11.39
324.16
253.23
258.82

AA455896
1181
glypican 1
3.46
0.00887
16.1
4.35
40.39
120.52
137.84
66.93

AA456326
1191
EST
3.35
0.00489
17.08
2.74
30.38
111.5
102.17
68.09

AA456845
1198
KIAA0680 gene product
#N/A
#N/A
23.95
17.11
17.99
67.15
63.46
49.27

AA459256
1212
lectin, mannose-binding, 1
3.01
0.00094
3.83
8.1
8.32
65.91
63.36
39.92

AA460661
1229
EST
7.02
0.00053
−1.52
−6.03
15.81
184.62
198.21
108.17

AA463876
1252
EST
3.31
0.00109
9.81
11.89
10.39
73.95
73.76
46.64

AA465381
1272
EST
#N/A
#N/A
88.83
36.24
130.22
102.73
113.07
52.43

AA479968
1321
arylsulfatase A
9.01
0.00224
37.97
20.36
45.8
331.32
312.63
97.49

MADS box transcription enhancer factor 2,

AA480997
1324
polypeptide A (myocyte enhancer factor 2A)
#N/A
#N/A
16
20.58
9.93
68.53
55.62
63.6

AA481057
1325
EST
#N/A
#N/A
16.3
18.55
8.1
33.83
37.89
23.22

AA486407
1347
EST
#N/A
#N/A
33.22
47.88
28.61
81.72
97.02
55.07

AA486567
1350
EST
5
0.00002
4.65
2.5
21.62
131.53
98.76
95.59

AA486794
1351
EST
#N/A
#N/A
49.57
52.25
18.73
78.8
72.55
31.84

AA487503
1356
EST
8.85
0.00012
13.8
17.99
8.76
220.45
255.47
119.11

AA490882
1381
EST
3.29
0.00319
20.67
13.84
27.06
100.67
98.47
54.46

AA490890
1382
EST
3.02
0.00007
20.26
21.34
9.23
75.61
65.02
33.37

AA496927
1402
EST
#N/A
#N/A
24.89
26.85
9.47
58.2
58.42
17.68

lectin, galactoside-binding, soluble, 8

AA598685
1435
(galectin 8)
#N/A
#N/A
16.45
11.35
11.87
55.9
55.08
42.18

AA599365
1449
decorin
#N/A
#N/A
36.41
34.43
21.53
83.84
84.81
43.41

AA600248
1461
EST
#N/A
#N/A
59.11
59.91
32.47
80.55
71.14
61.42

AA609715
1488
EST
#N/A
#N/A
−1.49
−3.92
10.63
29.09
33.14
17.26

AA621796
1531
kinesin family member 3B
4.44
0.00032
21.81
23.64
8.64
128.01
124.81
70.04

C20653
1578
EST
10.59
0.00001
7.99
2.12
11.85
251.82
299.09
106.09

D11802
1597
angiotensinogen
5.65
0.00009
55.88
52.43
25.14
319.73
291.02
132.07

D45529
1662
EST
3.82
0.00193
12.24
−3.36
29.18
126.63
109.06
70.64

D59554
1698
EST
6.7
0
6.09
9.79
34.83
184.48
158.33
79.55

D60769
1703
KIAA0096 protein
4.31
0.00142
13.44
13.91
10.95
119.96
107.2
86.36

butyrobetaine (gamma), 2-oxoglutarate

dioxygenase (gamma-butyrobetaine

F10380
1816
hydroxylase)
#N/A
#N/A
36.92
34.01
13.56
106.49
93.71
83.35

F10874
1823
EST
4.19
0.00025
233.85
209.96
107.99
1016.95
990.04
477.31

H03348
1833
claudin 1
5.77
0.0001
1.48
7.75
17.79
135.1
134.05
75.43

H16098
1885
EST
#N/A
#N/A
45.29
37.73
26.92
87.28
94.49
38.15

H17472
1888
EST
#N/A
#N/A
12.2
9.54
8.57
31.08
31.66
13.28

H47838
1936
carboxypeptidase B2 (plasma)
16.74
0.00002
−26.99
−41.82
25.87
401.55
412.78
188.81

4-nitrophenylphosphatase domain and non-

H56584
1951
neuronal SNAP25-like 1
9.5
0
1.95
10.13
31.43
223.03
233.37
105.28

v-Ki-ras2 Kirsten rat sarcoma 2 viral

H69138
1986
oncogene homolog
6.76
0.00142
42.88
30.87
38.35
328.51
313.13
218.8

H70627
1990
EST
#N/A
#N/A
17.89
17.62
8.85
42.72
41.34
11.7

H73535
1996
EST
6.89
0.00202
154.24
97.36
149.45
912.39
956.58
383.35

H77494
1999
EST
#N/A
#N/A
9.65
6.64
15.53
42.67
47.73
27.54

H81070
2006
RNA helicase-related protein
25.74
0.00126
93.43
62.01
121.29
2044.42
2051.11
615.84

H81964
2008
SEC14 (S. cerevisiae)-like 1
#N/A
#N/A
9.95
15.7
12.54
29.9
21.14
20.56

H82424
2009
EST
#N/A
#N/A
41.99
48.17
21.1
65.11
69.41
36.73

NOT3 (negative regulator of transcription 3,

H82735
2010
yeast) homolog
#N/A
#N/A
−1.13
6.14
29.78
58.77
54.86
35.76

H83109
2012
EST
16.55
0.00001
2.74
4.43
21.21
417.46
421.97
224.35

proline synthetase co-transcribed (bacterial

H93562
2038
homolog)
3.17
0.00113
20.83
14.13
20.46
89.3
84.36
37.72

H93745
2040
GS2 gene
#N/A
#N/A
4.52
8.01
8.31
47.92
46.53
28.87

H96897
2056
KIAA0336 gene product
#N/A
#N/A
35.22
19.98
42.05
48.46
50.39
33.36

H97587
2060
endothelin receptor type B
#N/A
#N/A
−5.07
−3.35
14.02
39.65
36.54
21.7

H97670
2061
EST
#N/A
#N/A
23.31
29.71
31.35
101.35
128.08
56.78

H99393
2076
endothelin receptor type B
3.43
0.00093
4.63
9.33
11.96
79.18
70.67
42.71

N21626
2444
EST
#N/A
#N/A
29.77
24.63
25.09
59.18
46.15
33.56

N35247
2499
EST
#N/A
#N/A
39.9
33.56
15.03
117.08
116.14
57.05

N54311
2563
EST
4.82
0.00183
9.77
9.36
25.17
160.29
130.17
124.7

N57934
2576
formiminotransferase cyclodeaminase
13.81
0.00171
806.55
477.9
939.39
9051.2
6373.16
8542.52

aminomethyltransferase (glycine cleavage

N59532
2584
system protein T) 6.73
0.00005
12.43
2.55
17.66
196.37
155.84
122.13

N62523
2591
hepatic leukemia factor
5.02
0.00087
9.04
6.67
16.46
144.8
148.62
85.03

cell division cycle 42 (GTP-binding protein,

N63172
2598
25kD)
#N/A
#N/A
26.88
33.1
24.75
60.99
57.64
40.01

N66130
2613
progesterone membrane binding protein
3.98
0.0106
29.02
21.05
33.88
172.14
181.78
114.84

prion protein (p27-30) (Creutzfeld-Jakob

disease, Gerstmann-Strausler-Scheinker

N67009
2621
syndrome, fatal familial insomnia)
3.55
0.00956
25.95
11.35
38.17
122.85
124.39
65.69

N67105
2623
EST
5.01
0.00176
−0.75
0.21
16.38
143.36
102.9
121.4

N67876
2627
insulin-like growth factor 1 (somatomedin C)
8.89
0.00042
11.81
15.88
8.82
267.41
145.79
238.35

N68133
2632
EST
#N/A
#N/A
2.35
−5.53
16.59
58.69
37.21
57.82

N68596
2635
betaine-homocysteine methyltransferase
40.99
0
−6.75
−13.81
19.15
1061.81
1013.27
574.42

N72200
2668
EST
#N/A
#N/A
12.93
14.15
14.26
57.8
56.14
30.12

R05309
2758
EST
3.72
0.0008
21.94
13.92
18.75
96.81
100.54
31.73

R06271
2765
EST
6.14
0.00063
23.1
18.95
21.07
208.75
221.65
107.72

R06273
2766
EST
#N/A
#N/A
138
103.77
75.66
235.98
183.78
122.56

R31104
2810
EST
#N/A
#N/A
−6.45
0.74
37.65
32.27
26.77
13.57

R40395
2840
lecithin-cholesterol acyltransferase
37.33
0.00032
0.98
−46.23
77.82
1192.03
1230.66
281.28

R40556
2842
EST
3.57
0.00184
8.98
8.28
11.75
91.55
95.59
58.66

R40946
2844
crystallin, zeta (quinone reductase)
6.14
0.00156
18.65
19.52
14.3
205.48
220.3
137.27

R45480
2862
cyclin K
#N/A
#N/A
27.21
17.36
21.39
71.04
79.77
50.88

R62519
2925
EST
10.83
0.00243
73.01
104.54
56.5
707.38
751.42
357.22

T56281
3150
RNA helicase-related protein
32.34
0.00002
71.16
62.87
44.81
2132.07
2146.52
824.76

carbamoyl-phosphate synthetase 1,

T59148
3157
mitochondrial
88.89
0
17.1
2.26
49.29
3384.09
3845.28
2295.81

T61256
3161
ketohexokinase (fructokinase)
13.59
0.00425
55.8
29.78
120.62
752.99
846.1
315.74

T61654
3165
apolipoprotein A-I
#N/A
#N/A
66.98
−33.89
208.52
9388.4
4297.02
12058.3

T64933
3173
EST
#N/A
#N/A
1.58
10.35
17.94
52.88
40.46
54.68

T65443
3174
EST
#N/A
#N/A
10.45
9.99
13.16
70.03
75.01
29

T66189
3177
glutaryl-Coenzyme A dehydrogenase
8.61
0.00003
17.08
20.49
23.82
269.19
301.13
136.96

T68855
3188
EST
34.04
0
8.38
6.98
9
800.27
911.26
406.27

T69020
3192
EST
5.39
0.00383
32.69
17.15
46.31
202.05
208.64
90.02

T69164
3194
EST
4.38
0.00548
34.31
17.81
30.85
173.2
167.2
85.34

UDP glycosyltransferase 2 family,

T74542
3214
polypeptide B10
32.36
0.00004
27.96
25.04
64.23
1374.78
1445.94
869.3

T84084
3233
EST
#N/A
#N/A
21.47
21.35
9.96
68.96
66.69
27.4

T84491
3234
CUG triplet repeat, RNA-binding protein 2
#N/A
#N/A
32.84
34.93
8.15
79.08
80.41
33.03

T86482
3237
transferrin
11.15
0.00006
7.6
9.41
12.34
316.82
197.03
302.36

T91161
3252
EST
3.48
0.00002
9.95
2.64
11.55
77.85
70.8
30.28

W45560
3522
EST
5.06
0.00996
86.81
62.95
81.92
369.61
354.89
158.02

W79422
3601
fumarylacetoacetate
14.94
0.00059
−18.4
−19.27
33.52
467.37
554.19
306.71

W87480
3630
STAT induced STAT inhibitor-2
3.24
0.01063
31.91
26.07
30.44
129.06
119.73
80.94

protein Z, vitamin K-dependent plasma

W87606
3632
glycoprotein
9.23
0.00085
2.53
−1.74
9.98
268.59
280.44
184.7

Z38192
3882
EST
3.35
0.00184
−0.28
−4.75
17.86
87.12
87.23
52.58

Z39833
3910
GTP-binding protein
16.89
0.00034
35.79
41.07
84.59
957.61
1080.1
674.72

homogentisate 1,2-dioxygenase

AF000573
1543
(homogentisate oxidase)
13.76
0.00002
9.05
13.23
17.33
380.3
348.9
256.4

phosphodiesterase I/nucleotide

pyrophosphatase 1 (homologous to mouse

D12485
1600
Ly-41 antigen)
4.57
0.00008
−2.69
−0.53
9.86
101.7
90.07
46.62

D14664
1616
KIAA0022 gene product
8.98
0.00011
14.15
13.51
9.07
233.08
248.97
111.44

aminomethyltransferase (glycine cleavage

D14686
1617
system protein T)
#N/A
#N/A
76.93
90.12
29.68
171.07
190.08
34.32

KIAA0025 gene product; MMS-inducible

D14695
1618
gene
6.48
0
28.53
28.21
12
196.04
197.12
77.25

D16350
1620
SA (rat hypertension-associated) homolog
3.83
0.00117
27.34
29.05
12.27
128.95
133.42
74.27

D31716
1647
basic transcription element binding protein 1
5.35
0.00086
16.08
23.65
17.64
166.06
203.79
87.22

D31815
1648
regucalcin (senescence marker protein-30)
10.55
0.00037
11.48
10.25
7
298.48
281.03
183.56

D49742
1668
hyaluronan-binding protein 2
18.13
0.00012
11.38
−0.72
41.45
509.66
531.78
127.5

potassium inwardly-rectifying channel,

D50582
1670
subfamily J, member 11
#N/A
#N/A
61.44
65.47
28.34
70.38
76.35
25.4

ficolin (collagen/fibrinogen domain-containing

D63160
1709
lectin) 2 (hucolin)
4.01
0.00391
51.13
46.11
30.07
219.26
228.53
125.06

Zic family member 1 (odd-paired Drosophila

D76435
1716
homolog)
#N/A
#N/A
7.52
9.44
7.51
28.48
22.05
16.54

D78011
1717
dihydropyrimidinase
21.37
0.00003
22.34
11.34
31.83
640.3
680.03
206.48

sterol-C5-desaturase (fungal ERG3, delta-5-

D85181
1750
desaturase)-like
9.56
0.00005
31.54
25.11
23.09
350.04
388.34
151.37

D85433
1751
EST
#N/A
#N/A
45.14
48.1
33.75
45.46
44.56
22.01

D86983
1758
p53-responsive gene 2
#N/A
#N/A
44.18
43.24
14.93
56.19
53
16.12

solute carrier family 23 (nucleobase

D87075
1760
transporters), member 1
4.15
0.00067
5.77
−0.83
26.24
119.77
104.75
72.62

carbamoyl-phosphate synthetase 1,

D90282
1769
mitochondrial
27.29
0.00002
8.24
12.24
8.02
712.98
819.32
415.69

cytochrome P450, subfamily lIE (ethanol-

H46990
1933
inducible)
3.2
0.00095
−0.27
−6.33
16.23
72.1
71.1
37.01

HG1148-HT1148

EST
17.51
0.00024
11.81
2.35
49.19
501.82
482.3
169.87

HG2167-HT2237

A kinase (PRKA) anchor protein 13
#N/A
#N/A
12.53
10.98
18.36
61.94
62.5
16.73

HG2755-HT2862

plastin 3 (T isoform)
#N/A
#N/A
50.51
23.74
81.64
158.94
142.23
112.33

HG4533-HT4938

protease inhibitor 4 (kallistatin)
11.01
0.00001
35.74
42.24
20.68
479.23
562.95
221.2

J02943
2090
corticosteroid binding globulin
18.98
0.00087
57.44
39.79
44.72
880.54
924.99
144.24

solute carrier family 2 (facilitated glucose

J03810
2099
transporter), member 2
21.99
0.00004
21.12
16.81
24.34
571.66
593.24
118.08

J04056
2104
carbonyl reductase 1
5.19
0.00001
9.77
22.83
29.45
145.33
139.19
73.11

J05037
2116
serine dehydratase
16.24
0.00015
12.71
32.78
67.98
626.47
497.97
306.18

J05158
2117
carboxypeptidase N, polypeptide 2, 83kD
8.52
0
2.27
−7.78
21.43
209.63
218.19
81.01

K02100
2123
ornithine carbamoyltransferase
10.24
0.00009
6.1
3.97
11.14
253.26
300.99
126.18

coagulation factor IX (plasma thromboplastic

component, Christmas disease, hemophilia

K02402
2125
B)
28.81
0.00001
10.4
2.94
28.08
742.92
734.01
215.88

L00972
2133
cystathionine-beta-synthase
7.19
0.00008
30.44
29.08
21.44
268.9
253.33
153.24

glucan (1,4-alpha-), branching enzyme 1

(glycogen branching enzyme, Andersen

L07956
2148
disease, glycogen storage disease type IV)
5.6
0.00029
19.13
18.57
16.75
166.17
184.57
75.67

L09717
2153
lysosomal-associated membrane protein 2
4.06
0.00034
16.78
9.78
21.83
115.12
111.26
57.66

murine leukemia viral (bmi-1) oncogene

L13689
2164
homolog
#N/A
#N/A
32.33
34.76
18.57
63.42
77.84
36.39

L19871
2172
activating transcription factor 3
#N/A
#N/A
72.2
31
78.72
98.22
85.66
61.41

L27050
2186
apolipoprotein F
10.26
0.00026
−23.8
−20.7
14.43
258.1
252.65
124.08

L27841
2187
pericentriolar material 1
#N/A
#N/A
58.75
58.95
40.61
90.06
82.71
28.43

L32140
2192
afamin
17.31
0.00003
9.44
16
10.75
426.89
464.97
221.11

L32179
2193
arylacetamide deacetylase (esterase)
23.83
0
22.94
24.96
16.06
688.97
675.71
305.75

L33799
2196
procollagen C-endopeptidase enhancer
#N/A
#N/A
87.45
73.5
89.14
230.54
248.1
130.08

bile acid Coenzyme A: amino acid N-

acyltransferase (glycine N-

L34081
2199
choloyltransferase)
11.96
0.00008
6.09
4.41
14.12
314.27
330.42
174.43

L48516
2220
paraoxonase 3
22.21
0.00004
36.05
28.85
37.25
896.92
896.69
337.05

M10058
2230
asialoglycoprotein receptor 1
23.96
0
−47.64
−42.75
75.52
591.6
603.68
188.25

M11437
2238
kininogen
18.38
0.00006
20.84
10.7
36.84
535.53
539.53
186.97

M11567
2239
angiogenin, ribonuclease, RNase A family, 5
32.25
0.0001
2.5
−18.19
58.03
1019.17
968.25
273.9

M12625
2245
lecithin-cholesterol acyltransferase
4.55
0.01584
110.15
128.06
73.94
447.22
425.61
138.52

M13143
2249
kallikrein B plasma, (Fletcher factor) 1
10.39
0.00019
38.55
37.19
32.81
402.05
441.15
122.27

M13699
2253
ceruloplasmin (ferroxidase)
15.85
0.00012
36.21
37.43
44.51
688.89
638.74
329.28

M14091
2257
thyroxin-binding globulin
10.66
0.00024
1.76
2.84
9.9
269.26
284.66
119.28

M15656
2268
aldolase B, fructose-bisphosphate
96.66
0
−44.61
−66.97
59.8
2911.78
2539.75
1883.04

coagulation factor V (proaccelerin, labile

M16967
2275
factor)
5.56
0.00047
22.71
26.49
30.11
204.85
248.05
88.92

M16973
2276
complement component 8, beta polypeptide
22.75
0.00001
20.03
23.43
31.9
686.99
714.82
203.16

M17466
2279
coagulation factor XII (Hageman factor)
9.76
0.00285
94.21
63.47
93.18
706.11
724.27
261.46

coagulation factor Xl (plasma thromboplastin

M20218
2288
antecedent)
6.4
0.00004
38.74
45.83
14.62
247.85
259.47
69.46

M20786
2290
alpha-2-plasmin inhibitor
16.95
0.00709
58.96
−14.12
171
1074.45
1132.06
620.06

alanyl (membrane) aminopeptidase

(aminopeptidase N, aminopeptidase M,

M22324
2295
microsomal aminopeptidase, CD13, p150)
#N/A
#N/A
224.68
25.21
471.53
365.81
363.02
134.32

M29194
2315
lipase, hepatic
12.18
0.00012
18.97
11.91
30.61
352.8
332.28
87.49

M30269
2323
nidogen (enactin)
3.4
0.00026
19.81
26.36
14.57
96.8
94.16
42.52

M63967
2378
aldehyde dehydrogenase 5
4.04
0.00058
34.59
36.64
5.46
164.38
178.74
87.39

M64174
2379
Janus kinase 1 (a protein tyrosine kinase)
#N/A
#N/A
10.42
10.81
15.82
59.51
59.38
27.77

M64554
2380
coagulation factor XIII, B polypeptide
5.87
0.00011
−4.73
−4.91
7.92
137.26
136.8
72.05

glycine dehydrogenase (decarboxylating;

glycine decarboxylase, glycine cleavage

M64590
2381
system protein P)
6.41
0.00002
14.28
17.87
8.65
152.26
127.72
82.96

protein phosphatase 2 (formerly 2A),

M64929
2383
regulatory subunit B (PR 52), alpha isoform
#N/A
#N/A
64.63
38.82
95.31
106.38
88.13
67.95

protein C inhibitor (plasminogen activator

M68516
2387
inhibitor III)
20.54
0
−1.34
−11.78
20.54
466.81
481.06
119.75

M68840
2388
monoamine oxidase A
3.96
0.01396
42.09
28.9
45.52
182
201.64
94.09

M69177
2391
monoamine oxidase B
11.64
0.00001
21.97
20.41
20.83
322.15
340.27
94

M74719
2395
transcription factor 4
#N/A
#N/A
8.97
15.15
10.62
46.89
44.78
12.66

M75106
2396
carboxypeptidase B2 (plasma)
40.63
0
19.77
30.19
22.24
1170.81
1124.59
329.77

M76665
2397
hydroxysteroid (11-beta) dehydrogenase 1
19.22
0.00004
33.41
17.51
23.86
628.97
670.88
196.22

M83772
2408
flavin containing monooxygenase 3
19.54
0
6.88
−0.95
15.39
504.14
595.51
245.03

SWI/SNF related, matrix associated, actin

dependent regulator of chromatin, subfamily

M88163
2415
a, member 1
3.37
0.00098
17.39
17.52
7.25
84.41
91.86
41.42

M88338
2416
serum constituent protein
#N/A
#N/A
134.22
128.76
53.79
155.51
140.27
70.28

M88468
2417
mevalonate kinase (mevalonic aciduria)
#N/A
#N/A
89.85
108.13
54.23
214.81
260.33
86.76

methylmalonate-semialdehyde

M93405
2423
dehydrogenase
23.06
0
16.51
27.77
20.66
679.66
734.58
307.25

M94065
2424
dihydroorotate dehydrogenase
6.47
0.00013
30.26
20.14
17.64
202.13
183.44
86.43

electron-transferring-flavoprotein

S69232
3026
dehydrogenase
4.9
0.00017
2.73
4.9
4.29
113.33
103.27
60.93

S70004
3028
glycogen synthase 2 (liver)
9.96
0.00001
−0.03
−4.28
11.42
225.1
212.32
102.76

S82240
3038
ras homolog gene family, member E
#N/A
#N/A
19.9
6.78
30.8
75.14
74.07
40.43

B-cell CLL/lymphoma 6 (zinc finger protein

U00115
3271
51)
5.18
0.00045
16.17
10.31
26.94
132.13
133.88
32.06

glucose-6-phosphatase, catalytic (glycogen

U01120
3273
storage disease type I, von Gierke disease)
13.41
0.00147
83.05
45.5
91.8
878.33
693.43
495.6

U03056
3279
hyaluronoglucosaminidase 1
6.64
0
12.68
11.77
4.73
139.32
137.21
43.97

complement component 8, gamma

U08198
3291
polypeptide
19.71
0
−29.27
−38.32
47.54
544.28
630.51
234.87

U11313
3296
sterol carrier protein 2
5.44
0.00187
17.39
0.82
35.86
181.8
228.15
99.25

acyl-Coenzyme A dehydrogenase,

U12778
3300
short/branched chain
5.68
0.00116
5.23
6.16
7.33
147.06
158.14
91.5

sulfotransferase family 2A,

dehydroepiandrosterone (DHEA) -preferring,

U13061
3301
member 1
11.32
0.00048
9.86
7.49
19.46
369.12
431.45
213.83

BCL2/adenovirus E1B 19kD-interacting

U15174
3309
protein 3
#N/A
#N/A
41.72
11.86
49.01
129.19
138.02
68.72

U15932
3310
dual specificity phosphatase 5
#N/A
#N/A
47.94
27.05
47.87
86.73
86.97
38.45

U17989
3315
nuclear autoantigen
#N/A
#N/A
14.21
12.72
6.13
44.22
41.28
19.09

GTP cyclohydrolase 1 (dopa-responsive

U19523
3319
dystonia)
5.25
0.00029
12.84
12.26
15.75
136.86
142.71
66.64

U20530
3321
secreted phosphoprotein 2, 24kD
16.93
0
12.63
11.54
9.93
383.92
421.24
128.02

nuclear receptor subfamily 1, group H,

U22662
3328
member 3
#N/A
#N/A
5.71
14.46
20.18
63.21
58.72
37.5

U31342
3343
nucleobindin 1
#N/A
#N/A
77.59
66.2
40.03
183.59
197.29
58.86

U32989
3347
tryptophan 2,3-dioxygenase
10.07
0.02825
166.12
22.7
333.99
527.61
473.11
268.8

cytochrome P450, subfamily IIJ (arachidonic

U37143
3353
acid epoxygenase) polypeptide 2
#N/A
#N/A
33.79
28.24
31.46
116.06
131.46
48.68

U37547
3354
apoptosis inhibitor 1
#N/A
#N/A
29.52
19.51
48.74
93.6
112.45
52.27

aldehyde dehydrogenase 10 (fatty aldehyde

U46689
3365
dehydrogenase)
3.5
0.01292
31.22
25.36
49.19
124.41
136.16
53.23

protein phosphatase 1, regulatory (inhibitor)

U48707
3370
subunit 1A
14.22
0
−1.33
−1.45
20.92
319.97
310.24
125.51

U49082
3372
transporter protein
9.17
0.00088
71.87
46.71
56.13
563.34
515.31
179.82

ATP-binding cassette, sub-family C

U49248
3373
(CFTR/MRP), member 2
7.06
0.00067
30.01
26.03
36.14
231.96
249.25
91.2

U50929
3379
betaine-homocysteine methyltransferase
36.91
0
8.63
2.82
20.35
898.57
865.9
313.61

U57094
3393
RAB27A, member RAS oncogene family
#N/A
#N/A
30.85
31.58
23.86
93.06
93.79
50.75

MAD (mothers against decapentaplegic,

U59423
3398
Drosophila) homolog 1
#N/A
#N/A
17.46
16.81
10.17
60.5
51.09
37.25

nuclear receptor subfamily 1, group H,

U68233
3411
member 4
6.76
0.00022
19.94
9.8
29.99
198.25
233.6
83.71

U69141
3413
glutaryl-Coenzyme A dehydrogenase
3.06
0.00053
35.13
27.91
13.89
108.36
119.26
34.82

U72515
3415
putative protein similar to nessy (Drosophila)
#N/A
#N/A
45.44
58.93
45.12
137.35
138.01
55.38

hydroxyacyl-Coenzyme A dehydrogenase,

U73514
3418
type II
3.79
0.01392
9.85
−22.7
56.91
159.74
161.9
127.8

U77396
3425
LPS-induced TNF-alpha factor
4.47
0.00108
30.53
33.74
31.54
169.83
141.36
87.43

retinoic acid receptor responder (tazarotene

U77594
3427
induced)2
11.95
0.00527
94.59
122.86
71.01
838.98
864.02
313.87

U79716
3436
reelin
3.51
0.00053
14.44
9.15
15.58
90.6
101.49
36.51

U81607
3439
A kinase (PRKA) anchor protein (gravin) 12
#N/A
#N/A
18.75
8.46
50.91
82.7
78.31
62.79

solute carrier family 31 (copper transporters),

U83461
3443
member 2
#N/A
#N/A
24.64
21.28
13.16
51.79
48.53
20.85

U85193
3446
nuclear factor I/B
#N/A
#N/A
21.84
23.61
4.44
72.71
68.69
32.02

solute carrier family 17 (sodium phosphate),

U90544
3453
member 2
6.42
0.00023
−3.14
−5.18
19.12
157.41
168.92
63.8

protein C (inactivator of coagulation factors

X02750
3670
Va and VIIIa)
7.04
0.00079
55.79
52.95
30.08
373.11
367.46
95.74

X06562
3683
growth hormone receptor
10.87
0.00001
10.46
6.89
15.53
291.31
314.9
160.29

X07732
3690
hepsin (transmembrane protease, serine 1)
28.21
0
−8.34
−12
39.24
678.15
672.42
183.61

protein kinase, cAMP-dependent, catalytic,

X07767
3691
alpha
5.94
0.00028
16.15
19.43
11.48
152.58
160.88
73.73

X12662
3694
arginase, liver
20.59
0
11.33
10.15
12.81
486.71
479.11
199.71

X13227
3695
D-amino-acid oxidase
4.81
0.0002
25.1
33.95
26.2
166.22
147.21
77.49

acetyl-Coenzyme A acyltransferase 1

(peroxisomal 3-oxoacyl-Coenzyme A

X14813
3702
thiolase)
11.61
0.0002
59.4
71.51
42.45
712.58
704.45
258.91

X15393
3704
motilin
#N/A
#N/A
70.16
55.83
27.07
113.93
117.96
26.14

X16663
3711
hematopoietic cell-specific Lyn substrate 1
#N/A
#N/A
48.32
28.69
56.44
81.51
83.53
33.75

paired basic amino acid cleaving enzyme

(furin, membrane associated receptor

X17094
3714
protein)
8.5
0
−1.85
7.01
25.41
190.11
216.35
74.11

alanine-glyoxylate aminotransferase

(oxalosis I; hyperoxaluria I; glycolicaciduria;

X53414
3725
serine-pyruvate aminotransferase)
13.87
0.00003
138.92
110.29
90.59
1856.57
1888.79
846.06

X54380
3727
preganancy-zone protein
8.44
0.00059
4.93
3.19
19.26
274.41
255.4
203.47

alcohol dehydrogenase 4 (class II), pi

X56411
3734
polypeptide
25.14
0.00144
55.53
11.29
102.45
991.98
943.64
448.31

X57025
3739
insulin-like growth factor 1 (somatomedin C)
4.72
0.00087
5.88
10.95
10.22
120.82
100.54
85.16

UDP glycosyltransferase 2 family,

X63359
3756
polypeptide B10
13.66
0.00051
55.28
48.57
41.25
669.93
732.6
161.42

X63417
3757
c-myc promoter-binding protein
#N/A
#N/A
28.85
27.75
24.56
68.08
56.34
33.18

X76105
3791
death-associated protein
3.02
0.00944
30.12
33.72
31.36
108.68
118.36
56.76

butyrate response factor 2 (EGF-response

X78992
3799
factor 2)
4.69
0.01995
64.86
31.76
66.31
318.26
336.95
207.43

cadherin 5, VE-cadherin (vascular

X79981
3803
epithelium)
#N/A
#N/A
45.01
41.07
11.65
80.92
80.1
8.57

hydroxyacyl glutathione hydrolase;

X90999
3817
glyoxalase 2
5.27
0.00047
16.15
26.83
26.47
170.37
179.54
76.98

microsomal triglyceride transfer protein (large

X91148
3818
polypeptide, 88kD)
5.91
0.00045
15.37
3.85
31.49
173.77
189.11
83.82

X92396
3820
synaptobrevin-like 1
#N/A
#N/A
40.87
17.73
57.17
67.49
61.23
31.24

X95190
3829
acyl-Coenzyme A oxidase 2, branched chain
12.81
0
−80.53
−76.73
37.81
285.88
349.39
119.31

transcription factor binding to IGHM

X97160
3835
enhancer 3
#N/A
#N/A
61.31
49.54
30.41
75.26
66.36
29.46

aldo-keto reductase family 1, member D1

Z28339
3872
(delta 4-3-ketosteriod-5-beta-reductase)
24.66
0
3.67
3.48
5.1
527.72
552.17
156.66

Z47553
3936
flavin containing monooxygenase 5
6.17
0.0011
4.86
1.26
8.96
141.98
165.57
59.33

Z48054
3938
peroxisome receptor 1
#N/A
#N/A
46.89
51.87
23.55
78.16
80.88
26.87

Z48633
3941
EST
#N/A
#N/A
−5.51
−6.39
13.15
36.84
40.63
26.33

small inducible cytokine subfamily A (Cys-

Z49269
3942
Cys), member 14
18.46
0.00001
1.88
−25.63
41.94
526.13
532.29
166.67

Z49878
3943
guanidinoacetate N-methyltransferase
13.96
0.00021
44.63
45.34
41.76
615.57
659.09
196.31

K02766
2126
complement component 9
21.24
0
23.15
14.02
21.18
652.66
656.14
320.1

cytochrome P450, subfamily IVA,

L04751
2138
polypeptide 11
36.79
0.00004
32.39
23.29
32.64
1164.28
1183.4
334.08

intercellular adhesion molecule 1 (CD54),

M24283
2303
human rhinovirus receptor
3.19
0.04985
77.88
34.05
69.45
207.07
183.74
121.4

cytochrome P450, subfamily IIC

M61853
2369
(mephenytoin 4-hydroxylase), polypeptide 18
7.82
0.00024
12.17
12.44
4.36
191.94
204.27
91.68

S77410
3034
angiotensin receptor 1
10.4
0
18.77
17.34
10.85
266.59
284.37
98.14

U20938
3323
dihydropyrimidine dehydrogenase
3.92
0.00053
6.66
6.08
7.12
90.66
97.02
44.64

fasciculation and elongation protein zeta 2

U60061
3399
(zygin II)
#N/A
#N/A
61.44
29.18
68.3
55.02
66.29
38.2

mannose-binding lectin (protein C) 2, soluble

X15422
3705
(opsonic defect)
8.29
0.00015
2.28
2.69
7.25
208.25
221.14
123.22

hepatocyte growth factor (hepapoietin A;

X16323
3708
scatter factor)
#N/A
#N/A
10.65
6.56
6.59
32.58
30.52
9.66

Y00097
3841
annexin A6
3.4
0.00233
19.43
16.39
33.67
105.39
104.75
39.99

M15465
2266
pyruvate kinase, liver and RBC
6.1
0.00069
3.06
3.32
11.38
158.56
132.57
102.11

angiotensin receptor 1, angiotensin receptor

D13814
1611
1B
3.12
0.00101
13.86
10.01
12.82
79.69
75.71
45.03

HG2383-HT4824

cystathionine-beta-synthase
13.57
0.00035
−0.01
2.09
10.74
377.07
375.12
210.67

HG2730-HT2827

fibrinogen; A alpha polypeptide
25.1
0
17.62
12.16
24.49
720.93
681.36
269.11

HG2743-HT2846

caldesmon 1
3.33
0.00135
27.49
25.6
21.89
103.56
92.79
35.98

M83216
2406
caldesmon 1
4.27
0.00037
7.89
2.98
12.17
105.21
109.38
55.62

J03242
2092
insulin-like growth factor 2 (somatomedin A)
4.01
0.00042
40.37
45.32
15.53
179.86
172.23
104.64

J04093
2106
UDP glycosyltransferase 1
18.92
0
8.62
8.7
12.9
462.51
511
215.46

coagulation factor VII (serum prothrombin

M13232
2251
conversion accelerator)
5.9
0.00014
43.46
42.59
18.46
248.65
275.82
70.94

Y00339
3844
carbonic anhydrase II
6.89
0
6.23
−1.39
18.22
168.76
178.44
69.52

X02176
3669
complement component 9
9.61
0.00004
47.28
46.34
28.54
507.56
507.21
261.45

macrophage stimulating 1 (hepatocyte

growth factor-like), macrophage stimulating,

U37055
3352
pseudogene 9
18.28
0
−7.37
−38.2
47.48
549.49
626.51
217.69

glutathione S-transferase A2, glutathione S-

X65727
3765
transferase A3
73.64
0
21.03
17.39
15.18
2162.22
2183.18
1435.52

U80226
3438
4-aminobutyrate aminotransferase
#N/A
#N/A
39.69
51.46
20.33
86.94
91.76
24.15

U19495
3318
stromal cell-derived factor 1
4.59
0.00011
7.17
5.76
5.65
103.81
114.61
50.36

U08006
3289
complement component 8, alpha polypeptide
16
0.00111
47.06
31.92
47.52
633.01
661.72
102.98

ATP-binding cassette, sub-family B

M23234
2299
(MDR/TAP), member 4
10.05
0
−4.37
−11.49
29.05
255.03
242.93
112.08

M30257
2322
vascular cell adhesion molecule 1
3.11
0.00064
17.33
13.46
10.06
78.1
82.04
35.74

M86873
2413
plasminogen, plasminogen-like
17.54
0
−3.92
−8.08
6.71
410.11
403.69
218.51

M65134
2385
complement component 5
12.01
0.00012
2.31
3.66
7.43
303.27
337.95
151.33

cytochrome P450, subfamily IIC

X65962
3766
(mephenytoin 4-hydroxylase)
5.47
0.00014
36.73
31.48
11.66
247.79
149.39
208.59

CD36 antigen (collagen type I receptor,

M98399
2436
thrombospondin receptor)
#N/A
#N/A
4.71
4.58
5.51
47.65
38.28
35.2

glycine amidinotransferase (L-

X86401
3812
arginine: glycine amidinotransferase)
22.7
0
19.17
9.16
19.13
646
721.34
274.64

UDP glycosyltransferase 2 family,

U08854
3292
polypeptide B15
7.38
0.00005
10.72
6.45
10.71
181.08
184.97
91.81

U51010
3380
nicotinamide N-methyltransferase
27.79
0.00366
105.25
43.72
204.23
1589.66
1590.62
536.04

cytochrome P450, subfamily IID

(debrisoquine, sparteine, etc., -metabolising),

X07619
3689
polypeptide 7a (pseudogene)
4.96
0.00004
32.26
33.56
10.88
177.56
206.15
77.69

X64877
3763
H factor (complement)-like 3
14.6
0
14.6
7.51
21.01
387.8
402.95
151.23

X64877
3763
H factor (complement)-like 3
12.33
0
6.14
8.26
14.25
262.65
268.29
84.84

complement factor H related 3, complement

X98337
3837
factor H-related 4
13.5
0.00001
18.76
22.2
33.33
411.51
375.08
169.37

X94563
3828
EST
3.52
0.00928
76.79
66.4
52.64
274.91
244.92
177.63

N-acetyltransferase 2 (arylamine N-

D90042
1767
acetyltransferase)
7.06
0
5.13
18.92
32.5
167.38
176.16
66.7

M10943
2234
metallothionein 1F (functional)
3.88
0
53.15
52.73
8.81
217.65
186.71
86.73

aldo-keto reductase family 1, member C4

(chlordecone reductase; 3-alpha

hydroxysteroid dehydrogenase, type I;

S68287
3024
dihydrodiol dehydrogenase 4)
24.11
0
6.23
6.37
9.75
510.59
569.32
165.14

cytochrome P450, subfamily IVF,

U02388
3277
polypeptide 2
9.38
0.00001
−4.93
−3.43
18.14
207.48
207.15
90.12

aldo-keto reductase family 1, member C1

(dihydrodiol dehydrogenase 1; 20-alpha (3-

U05861
3284
alpha)-hydroxysteroid dehydrogenase)
23.22
0.00002
47.98
44.41
21.91
1070.69
962.74
359.01

L11931
2159
serine hydroxymethyltransferase 1 (soluble)
7.27
0.00041
−18.81
−31.65
26.43
188.25
181.11
114.89

L32961
2194
4-aminobutyrate amino transferase
#N/A
#N/A
15.64
7.44
15.63
76.44
79.62
26.55

M16594
2272
glutathione S-transferase A2
73.21
0
−3.62
−9.74
18.15
1602.11
1787.28
655.41

cytochrome P450, subfamily I (aromatic

L00389
2132
compound-inducible), polypeptide 2
#N/A
#N/A
69.38
86.39
64.81
222.59
184.81
121.16

cytochrome P450, subfamily IIA

M33317
2338
(phenobarbital-inducible), polypeptide 7
32.63
0
44.53
35.06
29.77
1613.89
1437.34
1086.43

cytochrome P450, subfamily IIA

U22029
3326
(phenobarbital-inducible), polypeptide 7
71.98
0
5.05
10.11
21.51
1968.7
1339.04
1937.45

cytochrome P450, subfamily IIA

X13930
3697
(phenobarbital-inducible, polypeptide 6
38.52
0
52.66
64.02
31.42
2408.66
1948.18
1843.46

[0140]

	Number	Date	Country
	60211379	Jun 2000	US
	60237054	Oct 2000	US

Gene expression profiles in liver cancer

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Publication Number

Date Filed

Date Published

Inventors

CPC

US Classifications

International Classifications

Abstract

Description

Claims

RELATED APPLICATIONS

Provisional Applications (2)