Gene expression profiling of antidepressant action in the brain

Abstract

Implementing gene expression to study drug action in the central nervous system is complicated by functional heterogeneity because of the existence of many different neuronal subtypes within the mammalian brain. The integration of laser capture microdissection (LCM) and RNA amplification with cDNA microarray technology allows for large-scale gene expression analysis at cellular level. Using this approach, we have generated gene expression profiles of imipramine, a reference antidepressant, and a new putative antidepressant, novelR1 in several laser-captured brain nuclei (locus coeruleus, dorsal raphe, hypothalamic paraventricular nucleus and hippocampus) of rats subjected to the chronic mild stress model (CMS) of depression.

Description

BACKGROUND OF THE INVENTION

[0002] Microarray technology represents a potentially powerful approach to identifying genes specifically expressed in different cell of tissue type [P. O. Brown and D. Botstein, “Exploring the new world of the genome with DNA Microarrays” (1999) Nat Genet, 21:33-7; D. Shalon, “Gene expression micro-arrays: a new tool for genomic research”, (1998) Pathol. Biol. (Paris), 46;107-9; S. M. Welford, J. Gregg, E. Chen, D. Garrison, P. H. Sorensen, C. T. Denny and S. F. Nelson, “Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization” (1998) Nucleic Acids Res, 26:3059-65]. The application of microarray to the study of gene expression patterns in the central nervous system is complicated by functional heterogeneity because of the existence of many different neuronal subtypes within the mammalian brain [D. H. Geschwind, “Mice, microarrays, and the genetic diversity of the brain [In Process Citation]” (2000) Proc. Natl. Acad. Sci. USA, 97:10676-8; S. J. Watson, F. Meng, R. C. Thompson and H. Akil, “The ‘chip’ as a specific genetic tool” (2000) Biol Psychiatry, 48:1147-56]. This heterogeneity consists of literally hundreds of brain nuclei that are in close proximity to each other as well as many different neuronal subtypes in cortical layers of different brain regions. We have demonstrated in a previous study that the integration of laser capture microdissection (LCM), T7 based RNA amplification and cDNA microarrays allows to profile gene expression at cellular level [L. Luo, R. C. Salunga, H. Guo, A. Bittner, K. C. Joy, J. E. Galindo, H. Xiao, K. E. Rogers, J. Wan, M. R. Jackson and M. G. Erlander, “Gene expression profiles of laser-captured adjacent neuronal subtypes” (1999) [published erratum appears in Nat Med 1999 Mar; 5(3):355], Nat Med, 5:117-22.; R. C. Salunga, H. Guo, L. Luo, A. Bittner, K. C. Joy, J. Chambers, J. Wan, M. R. Jackson and M. G. Erlander, “Gene expression analysis via cDNA microarrays of laser capture microdissected cells from fixed tissue” (1999) In M. Schena (Ed.), “DNA microarrays a practical approach”, Oxford University Press, Oxford].

[0003] Recently, expression profiling using microarrays has been successfully used to study the action of the topical anesthetic dyclonine in S. cerevisiae [Hughes, 2000 #346]. Implementing gene expression to study drug action in the central nervous system is complicated by functional heterogeneity because of the existence of many different neuronal subtypes within the mammalian brain [Geschwind, 2000 #373] [Watson, 2000 #442]. This heterogeneity consists of literally hundreds of brain nuclei that are in close proximity to each other as well as many different neuronal subtypes in cortical layers of different brain regions. Therefore, we reasoned that to study the in-vivo action of drugs there needed to be from the technical side, the ability to (1) microdissect small numbers of neurons (˜100) from selected nuclei/subnuclei; (2) amplify the extracted mRNA in a reproducible manner; and (3) generate robust cDNA microarray data. The integration of laser capture microdissection (LCM), T7 based aRNA amplification and cDNA microarrays technology allows profiling of gene expression from specific cell type in situ [Luo, 1999 #352] [Salunga, 1999 #347].

[0004] Acute tricyclic antidepressants and other classes of antidepressant have a relatively well defined pharmacological action/target in-vitro of presynaptic reuptake inhibition of biogenic amines (norepinephrine, serotonin, dopamine). However, clinical efficacy requires three to six weeks suggesting that in-vivo a more complex mechanism occurs [Nestler, 1998 #409] [Stanford, 1996 #252]. Given this lag in efficacy, it is reasonable to assume that the mechanism of action of chronic antidepressant treatment in vivo may in part involve the modulation of gene expression. Therefore, gene expression profiling of selected brain nuclei may help to elucidate the chronic mechanisms of antidepressant action.

SUMMARY OF THE INVENTION

[0005] The present invention provides gene expression profiles at a cellular level of multiple brain nuclei after CMS±chronic treatment with antidepressant imipramine. Imipramine, a potent inhibitor of norepinephrine (NE) and serotonin (5-HT) uptake was selected as reference compound. In addition, a new putative antidepressant was examined to determine whether different in-vitro pharmacological properties but similar behavioral effects of imipramine and the new compound in the CMS model result in similar gene expression patterns. This new compound displays U2 adrenoceptor and 5-HT7 receptor antagonism properties [Kennis, 2000 #394]. The present invention also provides potential new targets for drug discovery to identify compounds useful to treat depression and other neurological diseases and/or conditions.

BRIEF DESCRIPTION OF THE DRAWINGS

[0006] FIG. 1: Laser Capture Microdissection from Nissl-Stained Sections (10 μM).

[0007] Panel A: hippocampus including CA1, CA3 and DG before capture

[0008] Panel B: hippocampus after capture of CA1 cells (c) CA1 captured cells.

[0009] Panel C: Scale bar represent 200 μm.

[0010] FIG. 2: Body Weight and Sucrose Consumption in Animals Exposed to CMS.

[0011] Effect of chronic treatment with vehicle (1 ml/kg 2× per day), imipramine (10 mg/kg/day) and novelR1 (0.16 mg/kg, 2× per day)

[0012] Panel A: on the body weight, and

[0013] Panel B: the consumption of a 1% sucrose solution in controls (open symbols) and in animals exposed to CMS (closed symbols). Treatment commenced following 2 weeks of stress. Values are means +/−SEM.

[0014] *−p<0.05, **−p<0.01, *** −p<0.001; relative to vehicle- or drug-treated control groups.

[0015] −p<0.05, −p<0.01, −p<0.001; relative to drug-treated stressed animals at Week 0.

[0016] FIG. 3: Experimental Reproducibility of LCM, T7 Based aRNA Amplification and cDNA Microarray Procedure.

[0017] Pair-wise similarities of gene expression profiles measured by the linear correlation coefficient.

[0018] Panel A: average linear correlation coefficient (R) for each brain area (n =3 to 5 per group)

[0019] Panel B: examples of scatter plots showing the individual linear correlation coefficient for two groups of rats (control/vehicle DR and control/vehicle CA3).

[0020] FIG. 4: Gene Expression Profiling of Laser Captured Brain Nuclei of Vehicle/Control Rats.

[0021] Panel A: table showing the number of genes expressed in each the laser-captured nuclei (100 cells) according our criteria for a call of presence (i.e. 3 fold above background). The number of genes uniquely expressed in one of these nuclei is also given

[0022] Panel B: two-dimensional hierarchical cluster analysis of the 871 genes (horizontal axis) detected in at least one of the region investigated (vertical axis). Red, high intensity (log10 scale), black not expressed (below 3 fold the background). The 7 regions on the vertical axis were assembled into a dendrogram, where items are joined by very short branches if they are similar to each other and by increasingly longer branches as their similarity decreases

[0023] Panel C: distribution of several genes for specific laser-captured brain region, data represent the average fluorescence intensity. Note that the fluorescence intensity readings for vasopressin and oxytocin in PA and MG correspond to the maximal intensity.

[0024] * The anatomical distribution of these genes matched the distribution previously described in the literature: vasopressin [Hallbeck, 1999 #359], oxytocin [Burbach, 1987 #354], somatostatin [Fitzpatrick-McElligott, 1988 #358], dynorphin [Morris, 1986 #364], tyrosine hydroxylase [Tohyama, 1998 #348], serotonin transporter [Swan, 1997 #419], galanin [Tohyama, 1998 #348], RGS14 [Traver, 2000 #416], H3 histamine receptor [Lovenberg, 1999 #338], mineralocorticoid receptor [Reul, 1985 #424].

[0025] FIG. 5: In situ Verification of the cDNA Microarray Data for Tyrosine Hydroxylase mRNA by ISHH.

[0026] Autoradiograms of frontal sections (left hemisphere) through the locus coeruleus hybridized with cRNA probes for tyrosine hydroxylase mRNA. (a, c, e) control; (b, d, f) stressed; (a, b) vehicle; (c, d) imipramine treated (10 mg/kg/day); (e, f) novelR1 treated (0.16 mg/kg, 2× per day) (g) Bound radioactivity of tyrosine hydroxylase cRNA probe in locus coeruleus of each group of animals. Values are means ±SEM n =3-5. Differences between control and CMS or drug treated groups were statistically significant. ***p<0.001. Scale bar represents 0.5 cm.

[0027] FIGS. 6: Overlapping and Non Overlapping Gene Expression Pattern in Unstressed and CMS Drug Treated Rats in the 7 Different Nuclei.

[0028] The diagrams show the number of genes with the indicated patterns.

[0029] Panel A: unstressed and CMS imipramine treated animals

[0030] Panel B: unstressed and CMS novelR1 treated animals

[0031] Panel C: uniquely changed in CMS imipramine and NOVELR1: the subset of genes with an accession number overlapping are listed.

DETAILED DESCRIPTION OF THE INVENTION

[0032] Gene expression profiling of antidepressants should be carried in the context of a behavioral model of depression. The chronic mild stress (CMS) model, a behavioral model of depression for which predictive, face and construct validities have been demonstrated was selected [Willner, 1992 #150] [Willner, 1997 #144] [Yadid, 2000 #422]. The CMS model was developed to mimic anhedonia, a core symptom of depressive disorders. Chronic sequential administration of a variety of mild stressors causes a decrease in responsiveness to rewards in rats, which is reversed by chronic administration of antidepressants drugs [Willner, 1992 #150]. The CMS model of depression also causes a decrease in body weight [Forbes, 1996 #413] but the magnitude of this decrease is minor and the validity, reliability and utility of the CMS is overall well recognized [Yadid, 2000 #422] [Argyropoulos, 1997 #205] #] [Willner, 1996 #226].

[0033] The locus coeruleus (LC), dorsal raphe (DR), hypothalamic paraventricular nucleus (PVN) magno and parvocellular division (MG, PA) and hippocampus (CA1, CA3 and DG) were selected for the present study. About one hundred cells were laser-captured in each of these nuclei. These regions were selected based on the location of the sites of action of the drugs and the critical neuroanatomical substrate for the stress response. In an autoradiographic analysis of the in vivo distribution of [3H]imipramine in rat brain, the locus coeruleus (LC) and the hippocampus have been shown to be the primary sites of action of imipramine [Duncan, 1991 #407]. Imipramine has also been shown to interfere with the serotoninergic transmission, therefore the dorsal raphe was selected in the present study. The LC is a critical neuroanatomical substrate for the stress response [Brady, 1994 #37] [Nestler, 1999 #240] [Valentino, 1998 #71], the PVN was added to the list of the investigated nuclei because of its role in the stress response [Weiss, 1994 #36]. Information on the neuroanatomical distribution of genes is critical for the process of understanding their function in the central nervous system. The integration of laser capture microdissection, T7 based RNA amplification and cDNA microarrays allows dissection of neuronal heterogeneity and at the same time to measure the gene expression level of thousands of genes. We have built a catalogue of rat brain-nuclei specific gene expression profiles. The following seven brain nuclei (100 cells) were analyzed: locus coeruleus (LC), dorsal raphe nucleus (DR), hypothalamic paraventricular (PVN, parvocellular division PA and magnocellular division MG) and hippocampus (CA1, CA3 and DG). Of the 2137 genes (unique mRNAs) interrogated, 871 (40.76%) gave a hybridization signal consistent with a call of presence in at least one brain region (i.e. at least three-fold above background level). The analysis was validated by the agreement of our findings with that of previously documented expression patterns of “signature” genes for specific brain nuclei. For example, abundant mRNA expression encoding the serotonin transporter was detected in DR cells but not detected in the other examined nuclei. The different nuclei investigated were found to have about four to seven percent in unique gene expression. The hierarchical clustering analysis shows that the two divisions of the PVN (PA and MG) were closely related and that similarly the three regions of the hippocampus (CA1, CA3 and DG) shared a similar gene expression profile. This study demonstrates the feasibility and utility of cellular brain nuclei profiling.

[0034] Using the LCM, T7 based amplification and cDNA microarray approach, we have generated a catalogue of cell specific gene expression profiles that can be used to determine which genes are expressed and where in the adult rat brain. Recently, Sandberg et al. [R. Sandberg, R. Yasuda, D. G. Pankratz, T. A. Carter, J. A. Del Rio, L. Wodicka, M. Mayford, D. J. Lockhart and C. Barlow, “Regional and strain-specific gene expression mapping in the adult mouse brain” (2000) Proc. Natl. Acad. Sci., 97:11038-43] and Zirlinger et al. [M. Zirlinger, G. Kreiman and D. J. Anderson, “Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei” (2001) Proc. Natl. Acad. Sci. 98:5270-5] have demonstrated the utility of brain region expression profiling. In these studies, gene expression analysis was performed on dissected brain regions. In the present study, a more neuroanatomically refined method (i.e. LCM) was introduced to isolate the cells of interest. The LCM technique allows the procurement of a selected cell population [S. J. Watson, F. Meng, R. C. Thompson and H. Akil, “The ‘chip’ as a specific genetic tool” (2000) Biol Psychiatry, 48:1147-56]. Brain tissues are composed of complex admixtures of different cell types, their biological meaningful analysis necessitate the procurement of a pure sample of the cells of interest. It is likely that general brain region dissection approaches would dilute the concentration of RNAs from neurons with RNAs from millions of potentially unrelated neurons and glia.

[0035] The correlation coefficient underlying the pair-wise similarities of gene expression profiles within one nuclei obtained in the present study demonstrate the reproducibility of the LCM, T7 RNA amplification and cDNA microarray approach. The high concordance between our data and published results validates the approach. However, some false negative findings were observed in the present study. Hallbeck et al. [M. Hallbeck, O. Hermanson and A. Blomqvist, “Distribution of preprovasopressin mRNA in the rat central nervous system” (1999) J. Comp. Neurol., 411:181-200] have reported the presence of low level of vasopressin mRNA in the hippocampus by in situ hybridization. In the present study, the level of vasopressin mRNA detected in the hippocampus was found between two- and three-fold different from the background and so, according to our criteria, was classified as not expressed. Low expression of somatostatin mRNA in the hippocampus has also been described in the literature [J. V. Priestley, M. Rethelyi and P. K. Lund, “Semi-quantitative analysis of somatostatin mRNA distribution in the rat central nervous system using in situ hybridization” (1991) J. Chem. Neuroanat., 4:131-53]. As observed for vasopressin, the intensity for somatostatin mRNA in the present study was below the criteria used for a call of presence. The stringent criteria used for a call of presence in the present study could account for these discrepancies. Sandberg et al. [R. Sandberg, R. Yasuda, D. G. Pankratz, T. A. Carter, J. A. Del Rio, L. Wodicka, M. Mayford, D. J. Lockhart and C. Barlow, “Regional and strain-specific gene expression mapping in the adult mouse brain” (2000) Proc. Natl. Acad. Sci., 97:11038-43] reported in their study that approximately 1% of the genes showing hybridization signals on the array were detected as differentially expressed between the four different brain regions investigated. In the present study, we found that the seven different nuclei investigated have about 4% to 7% in unique gene expression. The higher percentage of uniquely expressed found in our study could reflect the higher sensitivity achieved by the LCM approach.

[0036] In this study, we were able to classify the different laser-captured brain nuclei by hierarchical clustering analysis. As expected, we found that the two divisions of the PVN (PA and MG) were closely related and, similarly, the three regions of the hippocampus shared similar gene expression profiles. The dendrogram in FIG. 3 represents a new approach to classify brain nuclei. In conclusion, this study demonstrates the feasibility and the utility of cellular brain nuclei profiling. The following examples are intended to illustrate but not limit the present invention.

EXAMPLE 1

[0037] Behavioral Procedure

[0038] The stress procedure was conducted on male Wistar rats as previously described [Dziedzicka-Wasylewska, 1997 #224]. On the basis of sucrose intake scores following two weeks of stress, both stressed and control groups were divided further into matched subgroups (n=8), and for the subsequent five weeks received twice-daily intraperitoneal injections of vehicle (isotonic mannitol solution, pH 4.0, 1 ml/kg) or novelR1 (0.16 mg/kg). Once-daily intraperitoneal injections of imipramine (10 mg/kg) were used as the reference treatment. At this dose, imipramine has been shown to cause stable and comparable effects after chronic treatment in all previous studies using this experimental protocol [Willner, 1997 #144]. Sucrose tests were carried out twenty-four hours following the last drug injection (in the case of b.i.d. regime, the second injections on the day preceding the sucrose tests were omitted).

[0039] Drugs

[0040] The following agents were used: imipramine HCl (RBI, Natick, Mass.) and novelR1.

[0041] Statistics

[0042] The behavioral results obtained in this study were analyzed by multiple analysis of variance with three between-subjects factors (stress/control, drug treatments and successive sucrose tests). Fisher's LSD test was used for post-hoc comparisons of means.

[0043] Tissue Preparation

[0044] Twenty-four hours after the final injection of vehicle, imipramine or novelR1, five representative animals from each group were decapitated, and their brains were removed, placed in cryomolds, covered with Tissue-Tek tissue embedding medium (OTC) and snap-frozen in dry ice-cold 2 methyl butane (−60° C.). Ten μm-thick coronal sections in the mid-regions of the PVN (bregma—1.80 mm), hippocampus (bregma—3.30 mm), DR (bregma—1.78 mm) and LC (bregma—9.80 mm) were cut using a cryostat, mounted on non-coated, clear microscope slides and immediately frozen on a block of dry ice. The sections were stored at −70° C.

[0045] Laser Capture Microdissection

[0046] A quick Nissl (cresyl violet acetate) staining was used to identify the neurons as described [Salunga, 1999 #347]. The PixCell II System from Arcturus Engineering, Inc. (Mountain View, Calif.) was used for LCM. According to the manufacturer's protocol, one hundred neurons were captured in each region of interest of each animal (LC, DR, MG, PA, CA1, CA3 and DG). Example of laser-captured cells in CA1 region is shown in FIG. 1.

[0047] RNA Extraction and Amplification of LCM Samples

[0048] The total RNA was extracted from the individual LCM samples as described [Salunga, 1999 #347] with modifications as specified below. For total RNA extraction, a small volume (20 μl/LCM sample) of denaturing buffer (Micro RNA isolation kit, Stratagene: San Diego, Calif.) containing 2-mercaptoethanol (10 μl/ml, Sigma, St Louis, Mo.) and polyinosine (300 ng/LCM sample, Sigma: St Louis, Mo.) was used. The samples were incubated at 42° C. for ten minutes, and loaded onto a pre-rinsed Microcon-100 column (Millipore: Bedford, Mass.). After two rinses with 500 μl Rnase-free water, the columns were inverted and the samples collected by brief centrifugation. The samples were then processed for two rounds of RNA amplification as described [Salunga, 1999 #347] with modifications for the DNA and RNA purification steps. Quiaquick PCR purification kit (Qiagen: Valencia, Calif.) and RNAeasy Mini Kit (Qiagen: Valencia, Calif.) were used for purification steps. Polyinosine (100 ng) was added to each sample before purification of DNA or aRNA.

[0049] cDNA Microarray

[0050] A cDNA microarray containing 2147 cDNA clones (corresponds to 2137 unique mRNAs) was used in this study. cDNA clones were obtained commercially from Research Genetics (IMAGE consortium), Incyte Genomics as well as internal sources. All clones were verified by DNA sequencing. Each clone was printed as two independent spots on a given chip. A contact pin microarrayer (Generation III Array Spotter, Molecular Dynamics) was used to spot the clones in duplicate. Microarrays were hybridized and scanned with a confocal laser scanner (Array Scanner, Molecular Dynamics) with excitation at 532nm and collection through a 550 to 600nm band width filter, the PMT set to 630V. Image analysis was performed as previously described [Salunga, 1999 #347].

[0051] Statistical Analysis

[0052] Hybridization of each sample was performed on two identical microarrays. Each microarray was normalized at the 75 percentile (intensity of the 75 percentile was scaled to 100). Intensity of each clone on an individual microarray was then measured as an average of the intensities of the two corresponding spots, and the intensity of each clone in the sample was further determined as average of the intensities on the two identical chips. The pair-wise similarity of gene expression profiles within a group of same samples (same cell type under identical treatment) was examined by scatter-plot and the correlation coefficient was calculated. Samples having a correlation coefficient of R <0.89 with respect to the majority were treated as out-liers and were excluded for further analysis (at least three rats were included in each group). The intensity of each clone in one particular type of samples was subsequently further defined as the median of intensities of that clone in remaining qualified samples in that group. The resulting intensity matrix (N×M) (N: number of clones; M: number of sample types) was further normalized (spline normalization) so that the distribution of the intensities of all the clones for each individual sample type was fitted to a smooth cubic B-spline. The spline normalization could reduce abnormality in the distribution of the intensities in particular samples caused by saturation in image processing.

[0053] In addition to the 2147 clones, fifteen plant cDNA were printed on the same microarray. The intensities of these fifteen plant cDNAs were measured and processed in the same manner as other clones, and used as negative controls. The average intensity of the fifteen plant genes in all M types of samples was defined as background. Each clone was then classified as absent in a cell population if its medium intensity was below the three-fold of the background; or as present if its medium intensity was three-fold above the background.

[0054] The ratio (fold change) of gene expression between two samples was calculated after applying *i minimum threshold at the background of plant genes (intensity lower than background was re-set to background). The criteria used to select statistically significant fold changes in gene expression between two samples was at least a 1.8 fold change. Hierarchical clustering was generated by using Cluster software (Stanford).

[0055] Quantitative In Situ Hybridization Histochemistry.

[0056] In situ hybridization histochemistry was performed according to the procedures described [Bonaventure, 1998 #353] on adjacent tissue sections of the one used for LCM. The plasmid (pBluescript II SK, Stratagene, San Diego, Calif.) containing the cDNA coding for tyrosine hydroxylase (GB:M10244) was linearized and [35S]UTP labeled cRNA probe was generated by in vitro transcription with T7 polymerase. Sections were hybridized at 50° C. with 1.106 c.p.m of [35S]UTP labeled cRNA probe (80 μl per section). After high stringency washes, the sections were exposed to Kodak BiomaxMR film for sixteen hours. [14C] standard strips (American Radiolabeled chemicals Inc., St Louis, Missouri) were co-exposed to allow densitometry. Autoradiograms were quantified with the aid of an MCID-M4 3.0 Image Analysis system (Imaging Research, St. Catharines, Ontario, Canada). Optical densities in the LC were transformed into levels of bound radioactivity after calibration of the image analyzer with grey-values generated by co-exposed standards. The hybridization signal was expressed as μCi/g. The Student's t-test was used for comparison between the groups.

[0057] Body Weight is Unchanged by CMS or Drug Treatment.

[0058] At the start of the study (Baseline) all animals weighed approximately 320 grams and after the initial two weeks of stress (Week 0) the body weights of control and stressed animals were comparable (375 +/−6 and 372 +/−9 g, respectively). At the end of the treatment period (Week 5), body weights of vehicle-treated control and stressed animals were comparable [Group effect: F(1,14)=0.011; p=0.919]. As compared to vehicle-treated groups, neither imipramine nor novelR1 had any significant effect on body weights in controls [IMI: F(1,14)=1.764; NS, novelR1: F(1,14)=1.241; NS] and in stressed [IMI: F(1,14)=1.002; NS, novelR1: F(1,14)=0.518; NS] (FIG. 2a).

[0059] Sucrose Intake is Normalized in CMS Rats by Chronic Imipramine/NovelR1 Treatment.

[0060] In the final baseline test, all animals drank approximately 13 grams of sucrose solution. Following the initial two weeks of stress (Week 0), the intakes remained at similar level in controls but fell to approximately 8 grams in stressed animals, resulting in a significant Group effect [F(1,14) 11.159; p<0.01]. As shown in FIG. 2b, such a difference between control and stressed animals treated with vehicle persisted for the remainder of the experiment [F(1 1,84)=5.563; p<0.001] and at the end of treatment period, the sucrose consumption in stressed animals receiving vehicle was significantly lower than that measured in control group (p<0.001). As compared to chronic vehicle administration, imipramine did not change the sucrose intake in control animals [Treatment effect: F(1,84)=3.344; NS, Treatment×Weeks interaction: F(5,84)=0.313; NS]. However, in stressed animals, imipramine gradually increased the sucrose consumption, resulting in a significant Treatment effect [F(1,84)=61.277; p<0.001], Treatment×Weeks interaction [F(5,84)=4.117; p<0.01], and Treatment×Group interaction [F(1,168)=13.353; p<0.001] after three weeks of treatment (p<0.001). This effect was maintained thereafter and at the end of treatment period (Week 5), the amount of sucrose solution consumed by these animals was comparable to that of vehicle-treated controls (p=0.168) and significantly higher than that of vehicle-treated stressed animals (p<0.001). The novelR1 like imipramine had no significant effect on the consumption of sucrose solution in control animals [Treatment effect: F(1,84)=0.315; NS, Treatment×Weeks interaction: F(5,84)=0.599; NS]. However, like imipramine, novelR1 fully reversed in stressed animals the CMS-induced deficit in sucrose consumption resulting in a significant Treatment effect [F(1.84)=51.123; p<0.001], Treatment×Weeks interaction [F(5,84)=2.882; p<0.05], and Treatment×Group interaction [F(1,168)=14.238; p<0.001].

[0061] As compared to Week 0 scores, the increase of sucrose intake reached statistical significance after two weeks of treatment with novelR1 (p=0.043). This effects was maintained thereafter and at the end of treatment period, the intake in this group of stressed animals did not differ from those measured in vehicle-treated controls (p=0.501) and were significantly higher than those of vehicle-treated stressed animals (p=0.001).

[0062] The Greatest Number of Genes Changing Their Expression Level in Response to the CMS Paradigm in Untreated Rats was Found in LC.

[0063] A total of 80 genes (3.79 %) were found to change their expression level in response to the CMS paradigm in untreated animals (versus the control/vehicle group). The greatest number of genes changing their expression level was observed in LC (53 genes)>DG (10 genes)>PA (9 genes), CA1 (9 genes)>DR (2 genes), CA3 (2 genes), MG (1 gene) in Table 1 (see below).

TABLE 1
		FOLD
ACC. NO	GENE	(CMS vs ctrl)	NUCLEUS
Catecholamine synthesis
M10144	Tyrosine hydroxylase	1.85	LC
Neuropeptides
A1045437	Neuropeptide Y**	2.11	DG
AA955779	Galanin	2.06	PA
M10088	dynorphin**	−2.52	DG
RNU10071	CART	−1.90	LC
Receptors, ion channels
AF052746	Chloride channel CaCC	3.27	LC
M81830	Somatostatin R2 (SSR2)	2.77	LC
AF027955	GPR27 R	−1.92	LC
Z30425	Nuclear receptor/orphan	−1.90	DG
	MB67/CAR
L14618	Calcitonin R	−1.81	PA
L14618	Calcitonin R**	−1.80	LC
	GABA signaling
L08493	GABA-A R alpha4 subunit	2.24	CA1
X54673	GAT1	−2.05	LC
Glutamate signaling
X94552	mGlu7 R	−2.21	LC
M81886	glutamate R 1*	−2.03	CA1
M64752	glutamate R 1*	−1.89	CAl
HSU08107	NMDA R subunit	2.23	LC
Calcium
AA819346	Parvalbumin**	1.93	DG
M31178	calbindin D28	1.87	CA1
M31178	calbindin D28	−2.21	LC
AA819345	Parvalbumin	−1.99	LC
L10284	Calnexin	−1.87	LC
Signal transduction
D83407	ZAKI-4*	−1.80	DR
Heat shock protein
M86389	Hsp27	−1.85	PA
Plasticity
X51396	MAP1B	−2.11	CA1
X60370	MAP1B	−1.83	CA1
Proteasome
D29956	ubiquitin isopeptidase	1.97	LC
D17296	Polyubiquitin	−2.01	LC
W07641	ubiquit-like protein SMT3B	−2.00	LC
Transcription factor
Y10926	RBP-L	2.16	LC
Y07688	NfiX	−2.38	LC
AF057691	TCF-3	−1.83	DR
W65013	similar to X07384 GLI	−1.85	CA3
	PROTEIN
p53
U67885	p53 binding prot 1	−2.37	LC
U28789	PACT	−2.01	LC
Others
X58526	L1 element	−2.39	LC
X58526	L1 element	−2.35	DG
100256	Sequence 7 from U.S. Pat.	2.38	LC
	No. 4900811**
100256	Sequence 7 from U.S. Pat.	−1.93	PA
	No. 4900811

[0064] These genes were classified in functional families (i.e. catecholamine synthesis, neuropeptides, receptors or ion channels, GABA signaling, glutamate signaling, calcium, signal transduction, heat-shock protein, plasticity, proteasome, transcription factors and p53). The genes that could be classified in these functional families and with an accession number are listed in Table 2 (containing 39 genes).

TABLE 2
Number of genes detected in each laser-captured nuclei (100 cells)
according our criteria for a call of presence (i.e. three-fold above
background). The number of genes uniquely expressed in one of these
nuclei is also given.
	Detected	Unique
	CA1	499	32
	CA3	527	22
	DG	527	24
	LC	513	43
	DR	510	38
	MG	519	21
	PA	520	25

[0065] The increase in expression level of tyrosine hydroxylase mRNA (GB: M10244) in the LC of CMS/vehicle rats was further confirmed by quantitative in situ hybridization (FIG. 5a and b).

[0066] For the glutamate receptor 1 (GB: M81886, M64752) and the microtubule associated protein MAPI (GB: X51396, X60370) two different clones (from different species) were spotted on the microarray and consistent changes in gene expression level were observed for both clones as shown in Table 1. MAP1B plays an important role in the extension of axons and dendrites.

[0067] The chloride channel CaCC (GB: AF052746) and the somatostatin receptor 2 (GB: M81830) mRNAs showed the biggest amplitudes of changes of their expression levels in response to CMS (i.e 3.37-fold and 2.77-fold, respectively).

[0068] Six genes (five with an accession number) were found to change their expression level in the CMS/vehicle group in two different laser-captured nuclei (i.e. calcitonin receptor GB: L14618 in PA and LC, parvalbumin GB: AA819346 in DG and LC, calbindin D28 GB: M31178 in CA1 and LC, LI element GB: X58526 in LC and DG and GB: 100256 in LC and PA) (Table 1). Noteworthy, two calcium-ion binding protein (parvalbumin and calbindin D28) were found among these six genes.

[0069] At the end of the behavioral experiment, two different endpoints in sucrose consumption levels were observed: 13 grams of sucrose intake including the following groups vehicle/control, imipramine/control, imipramine/CMS, novelR1/control, novelR1/CMS) and 8 grams of sucrose intake including the vehicle/CMS group (FIG. 2b). The differences in gene expression level between these two groups (i.e. 8 grams versus 13 grams) reflects either changes causal to the decrease in sucrose consumption level or changes in response/adaptation to the CMS paradigm. A total of 30 genes (1.4%) were found to change their expression level in the untreated CMS group uniquely (i.e. no change in any of the other comparisons performed). The largest set of genes changing their expression level after CMS exposure uniquely was observed in LC (26)>PA (2)>DR (1), CA1 (1). These genes are listed in Table 1. Interestingly, in the GABA signaling pathway the expression level of both GABA-A receptor and GAT-1 was changed by the CMS paradigm uniquely.

[0070] Overall Both Drugs Changed the Expression Level of a Larger Set of Genes Than the CMS Paradigm and NovelR1 Changed the Expression Level of More Genes Than Imipramine in Unstressed Rats.

[0071] Overall imipramine and novelR1 were found to change the expression level of more genes than the CMS paradigm in control animals (CMS: 80 genes, 3.79%; imipramine: 86 genes, 4%; novelR1: 306 genes, 14%). These changes in gene expression levels induced by imipramine or novelR1 in unstressed rats do not reflect a change in sucrose uptake. In all, the nuclei investigated (excepted CA3 and MG), chronic treatment with novelR1 changed the expression level of more genes than imipramine in control animals (FIG. 6).

[0072] For both drugs genes that changed their expression levels in more than one of the investigated nuclei were found (imipramine: 12 genes: Table 3, R10747: 42 genes: Table 4). Both drugs were found to increase tyrosine hydroxylase mRNA levels in LC (fold increase versus control/vehicle: imipramine, 2.27; novelR1, 3.37). This up-regulation of tyrosine hydroxylase mRNA level was confirmed by in situ hybridization (FIGS. 5c and 5d). Noteworthy, the pterin-4a-carbinolamine dehydratase (DCoH or PCD, GB: AA901316) which catalyses the recycling of the cofactor biopterin [Depaepe, 2000 #439] shared a similar expression pattern in LC (fold increase versus vehicle/control: imipramine, 1.98; novelR1, 2.70). DcoH is requested in association with tyrosine hydroxylase for dopamine biosynthesis. Co-localization of DCoH and tyrosine hydroxylase in LC neurons has been previously demonstrated [Depaepe, 2000 #439]

TABLE 3
		IMINCMS
ACC. NO.	GENE NAME	vs. IMI	NUCLEI
Apoptosis
U67885	p53 binding prot 1	3.12	DG
U59746	Bcl-w	2.00	CA1
AF022223	BAG-1	1.83	DR
Catecholamine synthesis
AA142680	dopamine beta-hydroxylase	1.95	LC
A1044610	dopa decarboxylase	1.81	LC
Energy production
V01556	mitochondrial nenome	2.36	DG
	fragment
V00680	mitochondrial genes coding	1.90	CA3
	for 16S and 12S
V00681	mitochondrial genes for	1.84	MG
	16S
V00681	mitochondrial genes for	−2.85	DR
	16S
X14848	mitochondrial genome	−2.32	CA1
V00681	mitochondrial genes for	−2.07	CA1
	16S
V00681	mitochondrial genes for	−2.04	PA
	16S
V01556	mitochondrial genome	−1.99	DR
	fragment
V00680	mitochondrial genes coding	−1.93	CA1
	for 16S and 12S
GABA signaling
L08495	GABA receptor alpha6	2.56	DG
X54673	GAT1	2.24	CA1
X54673	GAT1	2.14	DG
X14767	GABA-A receptor, beta 1	1.96	CA1
	subunit
X15376	GABA-A receptor, gamma	2.00	DG
	2 subunit
Glutamate signaling
AA297071	Similar to N-methyl-D-	1.97	LC
	aspartate glutamate receptor
U16129	Glutamate receptor (GluR4)	2.27	DG
Growth factors
M21571	platelet-derived growth	1.96	CA1
	factor (PDGFA) A chain
U66198	FGF13	1.91	CA1
U66198	FGF13	2.27	DG
Heat shock protein
M19645	BiP/GRP78/ER resident	2.18	LC
	HSP70
D13627	TCP-1 Hsp60, theta subunit	2.06	DR
AA823192	heat-shock protein 40	2.03	LC
X15187	HSP90	1.91	DR
M11942	70 kd heat-shock-like	1.89	LC
	protein
X63368	HSJ1	1.88	CA1
Neuropeptides
AI045437	neuropeptide Y	2.56	LC
AA818532	gamma-preprotachykinin A	1.99	DR
M10088	Dynorphin	1.86	MG
Plasticity
M16228	GAP-43	2.59	DG
X51396	MAP1B	−4.65	DG
Proteasome
U44839	ubiquitin C-terminal	4.27	DG
	hydrolase
D10699	ubiquitin carboxyl-terminal	2.17	LC
	hydrolase
D00761	proteasome beta 1 subunit	2.09	DR
U44839	ubiquitin C-terminal	1.93	LC
	hydrolase
AA859300	proteasomes C2 component	1.90	DR
W07641	ubiquit.-like protein	−2.79	DG
	SMT3B (SUMO-1)
X99585	ubiquit.-like protein	−2.60	DG
	SMT3B (SUMO-1)
M29859	proteasomes C2 component	−2.34	DG
D00763	proteasome alpha 4 subunit	−2.31	DG
X99585	ubiquit.-like protein	−1.99	MG
	SMT3B (SUMO-1)
AF079564	ubiquitin carboxy-terminal	−1.87	DR
	hydrolase ubp41
U75362	ubiquitin carboxy terminal	−1.84	DG
	hydrolase
M29859	proteasomes C2 component	−1.83	MG
AA859229	ubiquitin conjugating	−1.82	DG
	enzyme
Receptors, ions channels
Y07521	Kv3.1a = NGK2 potassium	2.94	DG
	channel; V-gated
U33267	Human glycine receptor	2.60	DG
	beta subunit (GLRB)
	mRNA, complete cds
	H3 Histamine Rec	2.09	DR
L14618	Calcitonin Rec	2.06	LC
X66842	Serotonin 2B Rec	2.05	MG
Z30425	Nuclear receptor/orphan	2.03	MG
	MB67/CAR
AF064876	BCNG-1 hyperpolarization	2.03 DG
	NSC channel = HCN1 =
	HAC2
AF027955	GPR27 Rec	1.96	DG
Y10148	NTR2 receptor	1.94	DG
	H3 Histamine Rec*	1.93	LC
X97121	Neurotensin 2 Rec	1.90	DG
M81253	Kv3.4 gene	1.86	LC
AA002993	Potassium channel Kv3.4a	1.85	DR
	(Raw3), V-gated
U07225	Purinergic (P2U)	2.88	DG
AI058645	Kv4.3 potassium channel	2.60	DG
X66842	Serotonin 2B Rec	2.23	DR
X66842	Setotonin 2B Rec	1.92	PA
Z30425	Nuclear receptor/orphan	1.88	DR
	MB67/CAR
U07225	Purinerpic (P2U)	1.87	PA
U12194	voltage-gated Na + channel	1.83	LC
	beta-1 sub (SCN1B) gene
M21948	dihydropyridine-sens Ca	1.83	CA3
	channel alpha-2 sub
M24898	Nuclear receptor alpha1	1.81	DG
	for thyroid horm
Signa transduction
D83407	ZAKI-4	3.41	DG
M38194	extracellular signal-	2.26	LC
	regulated kinase 1
M12673	guanine nucleotide-binding	−4.12	DR
	protein G-s, alpha
M29871	ras-related C3 botulinum	−2.69	LC
	toxin substrate (rac)
D14425	Calcineurin	−2.24	DG
M60156	Go alpha	−1.89	DR
Transcription factor
AF057691	TCF-3	3.35	DG
AF012923	Wig-1	2.22	LC
AF065386	Jab1	2.14	DR
W65013	Similar to X07384 GLI	−3.24	DG
	PROTEIN
X17163	c-jun	−2.50	DG
X12740	C-Jun of the transcription	−1.85	DG
	factor AP-1
Others
M25888	Lipophilin	7.94	DG
I00256	Sequence 7 from U.S. Pat.	5.89	DG
	No. 4900811
D28875	Osreonectin	3.83	DG
U49099	cis-Golgi p28 (p28)	2.14	DG
D28875	Osteonectin	2.07	PA
P11661	nadh-ubiquinone ox	1.89	DG
I00256	Sequence 7 from U.S. Pat.	1.89	LC
	No. 4900811
Z26634	ankyrin brain variant,	2.63	PA
	ANKB
M89646	ribosomal protein S24	2.32	DR
P11661	nadh-ubiquinone ox	2.10	CA1
M89646	ribosom protein S24	2.10	DG
M25888	lipophilin	2.09	CA1
M89646	ribosornal protein S24	−1.98	LC
U49099	cis-Golgi p28 (p28)	−1.94	LC
Z26634	ankyrin brain variant,	−1.90	DG
	ANKB

[0073]

TABLE 4
		R107474NCMS
ACC. No.	GENE NAME	vs. R107474	NUCLEI
Apoptosis
U59746	Bcl-w	2.11	DR
AF022223	BAG-1	2.05	LC
U59746	Bcl-w	1.85	CA1
U67885	p53 binding prot 1	1.84	PA
Calcium
AA819345	parvalbumin	3.18	CA1
AA819345	Parvalbumin	2.23	DR
M31178	calbindin D28	2.20	CA1
catecholamine synthesis
AA142680	dopamine beta-	2.34	LC
	hydroxylase*
energy production
M29341	glyceraldehyde-3-	2.24	LC
	phosphate dehydrogenase
X02231	glyceraldehyde-3-	2.09	LC
	phosphate dehydrogenase
V01556	mitochondria genome	2.07	MG
	fragment
M35826	mitochondrial NADH-	1.96	PA
	dehydrogenase (NDI)
glutamate signaling
U08107	N-methyl-D-aspartate	1.85	CA3
	receptor subunit
U08107	N-methyl-D-aspartate	1.81	DG
	receptor subunit
M81886	glutamate rec type 1	−2.58	CA1
	HBGR1)
U08 107	N-methyl-D-aspartate	−2.46	DR
	receptor subunit
M64752	glutamate rec sub	−2.35	CA1
	(GluH1)
Plasticity
M16228	GAP-43	2.03	LC
X60370	MAP1B	−2.21	CA3
receptors, ions channels
Y07521	Kv3.1a = NGK2	2.41	PA
	potassium channel; V-
	gated
AA875142	5HT3 receptor mRNA	2.08	LC
	H3 Histamine Rec*	2.05	LC
AJ225124	Hyperpolarization-act	1.82	LC
	cation channel HAC3
AA427267	SCN9a = PN1 Sodium	1.81	LC
	Channel alpha, V-gated
M59980	K Channel	−2.24	CA1
AA819622	thrombin receptor	−2.08	DG
L28175	Prostaglandin EP2	−1.99	LC
U12194	voltage-gated Na+	−1.83	LC
	channel beta-1 sub-
	(SCN1B) gene
signal transduction
AI071860	RGS14	2.64	CA1
M23612	GTPase-activating	2.16	CA1
	protein (GAP)
M29870	ras-related C3 botulinum	2.01	DR
	toxin substrate (rac)
transcription factors
W65013	Similar to X07384 GLI	−2.16	CA1
	PROTEIN.
J04509	JUN-D prot	−2.10	DR
AF062566	Sp1	−1.94	LC
Others
M30952	28S ribosomal RNA gene	2.92	PA
	fragment
U20553	P57	2.18	PA
M30952	28S ribosomal RNA gene	2.14	MG
	fragment
M93056	monocyte/neutrophil	2.12	PA
	elastase inhibitor
X92106	Bleomycin hydrolase	2.08	PA
U20553	P57	1.98	DG
X92106	Bleomycin hydrolase	1.87	CA3
M29548	elongation factor 1-alpha	1.83	DR
	(EF1A)
M93056	monocyte/neutrophil	1.80	DG
	elastase inhibitor
M29548	elongation factor 1-	−1.98	CA1
	alpha (EF1A)
M89646	ribosomal protein S24	−1.94	CA1
M89646	ribosornal protein S24	−1.89	CA1
X95591	ClD protein	−1.85	CA1
X95591	ClD protein	−1.80	CA3

[0074] The largest set of genes changing their expression level after chronic treatment with novelR1 was found in DG. Among these genes, the primary site of action of novelR1, the a2c adrenoceptor mRNA (GB: M99376) level was found to be increased (fold difference versus control/vehicle: 3.62).

[0075] Overlaps in the gene expression patterns of imipramine and novelR1 in unstressed animals were observed in PA (thirteen genes)>LC (ten genes), DG (ten genes)>DR (five genes)>CA1 (four genes)>MG (two genes). Among these overlapping genes, six (three with an accession number) were found to change their expression levels in two different nuclei (heat-shock protein 27, GB: M86389 in PA and DR; Gs, GB: M12773 in MG and PA; 5-HT2B receptor, GB: X66842 in DG and CA1).

[0076] 35% of the Genes Changing Their Expression Level in Response to the CMS Paradigm were Antagonized by Both Drugs Treatment.

[0077] Imipramine and novelR1 were found to antagonize the changes in gene expression level induced by the CMS paradigm of a similar number of genes (imipramine: 53 genes, novelR1: 55 genes). This corresponds to 68% to 69% of the changes induced by the CMS paradigm. For twenty-eight of these genes overlap in the gene expression profile of imipramine and novelR1 were observed.

[0078] The increase in expression level of tyrosine hydroxylase mRNA induced by the CMS paradigm was not antagonized by chronic imipramine or novelR1 treatment in LC. The level of tyrosine hydroxylase mRNA were found to be up-regulated in the imipramine or novelR1/CMS group (fold increase versus vehicle/control: imipramine, 3.12; novelR1, 4.41). The up-regulation of tyrosine hydroxylase mRNA level was also confirmed by in situ hybridization (FIGS. 5e and 5f). The level of dopamine β hydroxylase (GB: AA142680) mRNA, another enzyme involved in the catecholamine biosynthesis, was also increased by both drugs in CMS rats in LC (fold increase versus vehicle/control: imipramine, 1.95; novelR1, 2.34). Similarly, DcoH mRNA level was increased (fold increase versus vehicle/control: imipramine, 2.30; novelR1, 2.67).

[0079] In CMS rats Both Drugs Changed the Expression Level of a Similar Number of Genes in LC, DR, CA1, CA3 and PA but with Minor Overlaps in Their Expression Profiles.

[0080] In LC, DR, CA1, CA3 and PA, imipramine changed the expression level of a larger set of genes in CMS rats than in unstressed rats (FIG. 6a), whereas novelR1 changed the expression level of a similar number of genes in CMS and unstressed rats (FIG. 6b). Administration of imipramine or novelR1 to CMS animals normalized the sucrose intake to the control level (FIG. 2b). The genes that change their expression level in the drug treated/CMS group but not in the drug treated/control group could reflect a drug +CMS interaction. These changes in gene expression are either causal to the change in sucrose intake from 8 grams to 13 grams or are responding to the new behavioral state. Both drugs yield a similar number of genes reflecting the drug/CMS interaction in LC, DR, CA1, CA3 and PA. In DG and MG, the imipramine/CMS interaction induced greatest changes in gene expression than the novelR1/CMS interaction.

[0081] Minor overlaps in genes expression patterns between imipramine and novelR1 in CMS rats were observed: LC (four genes)>CA1 (two genes)>DR (one gene), PA (one gene). The overlapping genes with an accession numbers are listed in FIG. 6. Imipramine changed the expression level of a total of 184 genes in CMS rats, whereas novelR1 changed the expression level of 91 genes. The genes with an accession number were classified in functional families and are listed in Table 2 (imipramine) and Table 3 (novelR1). Thirty genes were found to change their expression level in more than one nucleus for imipramine and twelve genes for novelR1.

EXAMPLE 2

[0082] 2.1. Tissue Preparation

[0083] Five adult male Wistar rats (423 g±22) that were used as control animals in a behavioral paradigm were decapitated, their brains were removed, placed in cryomolds, covered with Tissue-Tek tissue embedding medium (OTC) and snap-frozen in dry ice-cold 2 methyl butane (−60° C.). Ten tm-thick coronal sections in the mid-regions of the PVN (bregma—1.80 mm), hippocampus (bregma—3.30 mm), DR (bregma—1.78 mm) and LC (bregma—9.80 mm) were cut using a cryostat, mounted on non-coated, clear microscope slides and immediately frozen on a block of dry ice. The sections were stored at −70° C. All efforts were made to minimize animal suffering and reduce the number of animals used.

[0084] 2.2. Laser Capture Microdissection

[0085] A quick Nissl (cresyl violet acetate) staining was used to identify the neurons as described [R. C. Salunga, H. Guo, L. Luo, A. Bittner, K. C. Joy, J. Chambers, J. Wan, M. R. Jackson and M. G. Erlander, “Gene expression analysis via cDNA microarrays of laser capture microdissected cells from fixed tissue” (1999) In M. Schena (Ed.), “DNA microarrays a practical approach”, Oxford University Press, Oxford]. The PixCell II System from Arcturus Engineering, Inc. (Mountain View, Calif.) was used for LCM. According to the manufacturer's protocol, one hundred neurons were captured in each region of interest of each animal (LC, DR, MG, PA, CA1, CA3 and DG). Example of laser-captured cells in CA1 region is shown in FIG. 1.

[0086] 2.3. RNA Extraction and Amplification of LCM Samples

[0087] The total RNA was extracted from the individual LCM samples as described [R. C. Salunga, H. Guo, L. Luo, A. Bittner, K. C. Joy, J. Chambers, J. Wan, M. R. Jackson and M. G. Erlander, “Gene expression analysis via cDNA microarrays of laser capture microdissected cells from fixed tissue” (1999) In M. Schena (Ed.), “DNA microarrays a practical approach”, Oxford University Press, Oxford] with modifications as specified below. For total RNA extraction, a small volume (20 μl/LCM sample) of denaturing buffer (Micro RNA isolation kit, Stratagene: San Diego, Calif.) containing 2-mercaptoethanol (10 μl/ml, Sigma: St Louis, Mo.) and polyinosine (300 ng/LCM sample, Sigma: St Louis, Mo.) was used. The samples were incubated at 42° C. for ten minutes, and loaded onto a pre-rinsed Microcon-100 column (Millipore: Bedford, Mass.). After two rinses with 500 μl Rnase-free water, the columns were inverted and the samples collected by brief centrifugation. The samples were then processed for two rounds of RNA amplification as described [R. C. Salunga, H. Guo, L. Luo, A. Bittner, K. C. Joy, J. Chambers, J. Wan, M. R. Jackson and M. G. Erlander, “Gene expression analysis via cDNA microarrays of laser capture microdissected cells from fixed tissue” (1999) In M. Schena (Ed.), “DNA microarrays a practical approach”, Oxford University Press, Oxford] with modifications for the DNA and RNA purification steps. Quiaquick PCR purification kit (Qiagen: Valencia, California) and RNAeasy Mini Kit (Qiagen: Valencia, California) were used for purification steps. Polyinosine (100 ng) was added to each sample before purification of DNA or aRNA.

[0088] 2.4. cDNA Microarray

[0089] A cDNA microarray containing 2147 cDNA clones (corresponds to 2137 unique mRNAs) was used in this study. cDNA clones were obtained commercially from Research Genetics (IMAGE consortium), Incyte Genomics, as well as internal sources. All clones were verified by DNA sequencing. Each clone was printed as two independent spots on a given chip. A contact pin microarrayer (Generation III Array Spotter, Molecular Dynamics) was used to spot the clones in duplicate. Microarrays were hybridized and scanned with a confocal laser scanner (Array Scanner, Molecular Dynamics) with excitation at 532 nm and collection through a 550 to 600 nm band width filter, the PMT set to 630V. Image analysis performed as previously described [R. C. Salunga, H. Guo, L. Luo, A. Bittner, K. C. Joy, J. Chambers, J. Wan, M. R. Jackson and M. G. Erlander, “Gene expression analysis via cDNA microarrays of laser capture microdissected cells from fixed tissue” (1999) In M. Schena (Ed.), “DNA microarrays a practical approach”, Oxford University Press, Oxford].

[0090] 2.5. Statistical Analysis

[0091] Hybridization of each sample was performed on two identical microarrays. Each microarray was normalized at the 75 percentile (intensity of the 75 percentile was scaled to 100). Intensity of each clone on an individual microarray was then measured as an average of the intensities of the two corresponding spots, and the intensity of each clone in the sample was further determined as average of the intensities on the two identical chips. The pair-wise similarity of gene expression profiles within a same cell type was examined by scatter-plot and the correlation coefficient was calculated. Samples having a correlation coefficient of R<0.89 with respect to the majority were treated as out-liers and were excluded for further analysis. The intensity of each clone in one particular nucleus was subsequently further defined as the median of intensities of that clone in remaining qualified samples in that nuclei. The resulting intensity matrix (N×M) (N: number of clones; M: number of sample types) was further normalized (spline normalization) so that the distribution of the intensities of all the clones for each individual sample type was fitted to a smooth cubic B-spline. The spline normalization could reduce abnormality in the distribution of the intensities in particular samples caused by saturation in image processing.

[0092] In addition to the 2147 clones, fifteen plant cDNA were printed on the same microarray. The intensities of these fifteen plant cDNAs were measured and processed in the same manner as other clones, and used as negative controls. The average intensity of the fifteen plant genes in all M types of samples was defined as background. Each clone was then classified as absent in a cell population if its medium intensity was below the three-fold of the background; or as present if its medium intensity was three-fold above the background. Hierarchical clustering was generated by using Cluster software (Stanford).

[0093] Gene Expression Profiling of Brain Nuclei is Reproducible.

[0094] Gene expression profiles were measured from seven different laser-captured brain nuclei in six different groups of rats (i.e. control/vehicle, CMS/vehicle, control/imipramine, CMS/imipramine, control/ novelR1, CMS/novelR1). To estimate experimental reproducibility within a group of rats, the pair-wise similarities of gene expression profiles were compared by calculating a linear correlation coefficient (FIG. 3). The average linear correlations coefficients (R) within one region ranged from 0.955 to 0.978 (n =3 to 5 per group, FIG. 3a). For examples, the correlation value for the DR in control/vehicle animals ranged from 0.95 to 0.98 (FIG. 3b). For CA3 the R values ranged from 0.96 to 0.98. These data suggest that the brain nuclei were clearly captured and that these nuclei are relatively homogenous in gene expression.

[0095] Different Brain Nuclei Have about 4% to 7% in Unique Gene Expression.

[0096] To further validate the LCM/cDNA microarray approach, the gene expression patterns of the seven laser-captured brain nuclei were compared within the control/vehicle groups (FIG. 4). Of the 2137 genes (unique mRNAs) analyzed, 871 (40.76%) gave a hybridization signal consistent with a call of presence in at least one brain region according our criteria (i.e. at least three-fold above background level). The number of genes detected within one region ranged from 499 to 527 (FIG. 4a). The number of genes unique to one of the seven investigated brain nuclei, according our criteria for a call of presence, ranged from 21 to 43 (FIG. 4a). The highest number of unique genes (43) was found in LC. All 419 genes that changed expression levels between the different areas of the brain are listed in Table 5.

[0097] To compare the overall gene expression patterns of the different brain areas two-dimensional hierarchical clustering was performed (FIG. 4b). Hierarchical clustering analysis showed similarities in expression patterns between the two divisions of the PVN and between the three regions of the hippocampus (FIG. 4b). For example, the dendrogram on the vertical axis shows that the two divisions of the PVN (PA and MG) were joined by a very short branch reflecting their similarities compared to the other areas (FIG. 4b) and the three regions of the hippocampus (CA1, CA3 and DG) were also located on a common branch. The LC was located on a different branch of the dendrogram, suggesting that this nuclei has the greatest difference in gene expression among the seven nuclei that were examined. This finding is consistent with the LC containing the highest number of genes that are enriched (described above).

[0098] The analysis was further validated by the agreement of our findings with that of previously documented expression patterns for “signature” genes for specific brain nuclei (FIG. 4c). For example, in our study, abundant mRNA expression encoding vasopressin (GB:AI072073) and oxytocin (GB:M88355) were detected in PA and MG cells, but not detected in the other examined nuclei. This finding is in agreement with previous studies [Hallbeck, 1999 #359] [Burbach, 1987 #354] [Tohyama, 1998 #348]. Other striking examples included mRNAs encoding tyrosine hydroxylase (GB: M10244) and serotonin transporter (GB: AA819178) to the LC and DR respectively (FIG. 4c).

	A	B
1		Name
2	neuropeptide	9174| UI-R-E1-fg-b-04-0-UI| AA955779| Rat galanin (a neuropeptide) mRNA, complete cds
3	neuropeptide	9168| UI-R-E1-fg-g-12-0-UI| AA955767| Rat mRNA encoding rat pre-prosomatostatin (isolated from a medullary thyroid carcinoma)
4		8723| UI-R-A1-ev-b-11-0-UI| AA926266| Rat VL30 element mRNA
5		8637| UI-R-E0-br-e-03-0-UI| AA866450| Rattus norwegicus interleukin-2 receptor beta chain (p70/75) mRNA, complete cds
6		8615| UI-R-A0-aj-e-08-0-UI| AA866381| Rat mRNA for hnRNP protein, partial
7	neuropeptide	8610| UI-R-A0-bm-a-06-0-UI| AA866347| Rat mRNA encoding rat pre-prosomatostatin (isolated from a medullary thyroid carcinoma)
8		8569| UI-R-A1-el-b-12-0-UI| AA926045| Similar to AF020760 H sapiens serine protease (Omi) mRNA
9	apoptosis	8540| UI-R-A1-es-c-03-0-UI| AA926004| Rattus norvegicus mRNA for 14-3-3 protein eta-subtype, complete cds
10	ion channel	81| 832845| AA427267| SCN9a=PN1 Sodium Channel alpha, V-gated
11		7888| UI-R-A1-eg-b-04-0-UI| AA924903| Similar to HUMKG1C Human mRNA for KIAA0045 gene, mRNA
12	ion channel	786| UI-R-EO-bu-g-03-O-UI| AA875142| Rat 5HT3 receptor mRNA, complete cds
13		7732| UI-R-A1-dz-c-12-0-UI| AA924656| Similar to AB005298 H sapiens BAI 2 mRNA
14		735| UI-R-E0-ck-e-08-0-UI| AA874900| Similar to AC004021 kelch protein
15		7233| UI-R-A1-dp-d-03-0-UI| AA901316| Rattus norvegicus DCoH gene
16		6980| UI-R-E0-dk-d-12-0-UI| AA900886| Similar to MMUBF Mouse ubf gene for transcription factor UBFmRNA
17		68| 775900| AA276133| CIC-2 Chloride Channel, V-gated
18		6611| UI-R-C0-hc-e-09-0-UI| AF020760| Omi
19	hsp	6565| UI-R-G0-UI-h-03-0-UI| L39370| Human Hsp27
20		6544| UI-R-C1-ke-c-01-0-UI| L28175| Prostaglandin EP2
21		6510| UI-R-E1-fu-h-10-0-UI| L11667| Human cyclophilin-40
22		6505| 2076313| L10284| Human calnexin
23		6457| 918411| D42055| hNEDD-4/KIAA0093, hect domain protein
24		644| UI-R-E0-cq-c-04-0-UI| AA875241| Similar to MMUBCM4GN M. musculus UBcM4 mRNAmRNA
25	hsp	6439| 2064663| D13627| TCP-1 Hsp60, theta subunit
26		6407| 749025| M11723| Blood coagulation factor XII
27		6406| 660902| M112331 Cathepsin D
28		6351| UI-R-C0-IG-e-10-0-UI| M24898| Nuclear receptor alpha1 for thyroid horm
29	hsp	6332| UI-R-AD0-we-g-01-0-UI| M196451 Human BiP/GRP78/ER resident HSP70
30	GPCR	6296| 7006963431 M818301 Somatostatin (55R2)
31	G protein signaling	6240| 2088210| M60156| Go alpha (G-protein)
32		6232| 1152703| M58051| FGFR3
33	GPCR	6204| 700311648| U07225| Purinergic (P2U)
34		6150| UI-R-AE0-xe-f-02-0-UI| M94335| Akt1/PKB/RAC
35		6118| UI-R-CO-gs-d-06-0-UI| U39738| PAK3
36		6068| UI-R-AA1-aab-c-10-0-UI| U20553| P57
37		60664| 583865| U20372| Calcium channel beta 3 (CCHB3); V-gat,aux
38	proteasome	6031| 478404| W07641| ubiquit.-like protein SMT3B (SUMO-1)
39	GPCR	5997| 701899983| U71092| GPCR37 (Orphan, public=GPR24)
40		5981| 1885026| U59167| Desmin
41	ion channel	5977| 700254854| U57352| ASIC2=MDEG=BNC1 brain Na chan; amil sens
42	5958| 947959| U47036| CCR5
43	GPCR	5957| UI-R-Y0-acc-e-12-0-UI| U469231 GPCR8 (Orphan, public)
44	hsp	5934| 464942| X63368| H. sapiens HSJ1 mRNA, DnaJ homolog
45	ion channel	5897| UI-R-Y0-aci-c-12-0-UI| X16476| Kv2.1=DRK1 potassium channel; V-gated
46	hsp	5889| UI-R-A0-ab-h-12-0-UI| X15187| Human gp96/GRP94, ER HSP90
47	5873| 1211032| X04434| IGF1R
48	5855| 701644254| Z30425| Nuclear receptor/orphan MB67/CAR
49	ion channel	5845| 493098| Y07521| Kv3.1a=NGK2 potassium channel; V-gated
50	transcription factor	5844| 944489| Y00864| SCFR/c-kit
51		5832| 677053| X99585| ubiquit.-like protein SMT3B (SUMO-1)
52	GPCR	5825| 701293873| X94552| Glutamate metabotropic (mGlu7)
53		5824| 2182578| X92106| Bleomycin hydrolase
54		5821| 700230143| X89576| Matrix metalloproteinase MT2-MMP
55		5814| 368357| X85237| splicing factor SF3a120
56		5809| 316104| X82153| Cathepsin K
57	hsp	5789| UI-R-C0-hc-d-08-0-UI| X74801| Human TCP-1 HSP60, gamma subunit
58	apoptosis	5763| 100400| 100400| 14-3-3 gamma
59	GPCR	5704| 701035392| 258| H3 Histamine Rec (GPCR97)
60	apoptosis	5694| 95332| 95332| 14-3-3 eta
61		5681| 112173| 112173| calcineurin A2
62		4716| 583498| AA142680| S50200 S50200 dopamine beta-hydroxylase [mice, Genomic/mRNA, 2274 nt]. Blastn P. = 4.6E-167
63		4715| 580798| AA139498| L41351 HUMPROS Homo sapiens prostasin mRNA, complete cds. Blastn P. = 2.5E-141
64		4699| 604709| AA161790| X05026 HSRHOB Human rho mRNA (clone 12). Blastn P. =1.5E-204
65		4262| 577610| AA426192| hUBC6
66		39517| UI-R-AG0-ww-b-07-0-UI| U63421| sulfonylurea rec (SUR1)
67	transcription factor	39504| UI-R-01-kw-b-11-0-UI| AF012923| Wig-1
68		394961UI-R-AD1-zn-f-05-0-UIIU438441cyclinD3gene
69		39495| UI-R-02p-nz-g-03-0-UI| U28789| PACT
70	polyamine synthesis	39494| UI-R-Y0-acv-f-12-0-UI| J04791| DCOR
71		39490| UI-R-C0-jh-b-10-0-UI| Y14296| BTEB-1
72	transcription factor	39485| UI-R-C0-is-f-03-0-UI| X17163| c-jun
73		39477| UI-R-E1-gf-e-12-0-UI| Y07701| cytosol alanyl aminopeptidase
74		39475| UI-R-C3-ti-d-08-0-UI| Y07836| helix-loop-helix prot
75	apoptosis	39461| UI-R-C0-jq-f-07-0-UI| AF022223| BAG-1
76		39460| UI-R-Y0-abk-h-03-0-UI| U77615| crx homeodomain prot
77		39456| UI-R-AE0-xm-h-07-0-UI| AFO31384| TWIK-related acid-sens K+ channel (TASK)
78	GPCR	39452| UI-R-C2-nh-f-03-0-UI| X51585| Adrenergic alpha1B Rec
79		39451| UI-R-C2-mq-h-08-0-UI| U23781| A1-d prot
80		39428| UI-R-E0-cd-a-02-0-UI| D29678| CDKS
81		39424| UI-R-C0-jh-c-05-0-UI| U28068| neuroD
82	GPCR	39418| UI-R-Y0-mj-a-06-0-UI| M58316| Adrenergic alpha2C Rec
83		39416| UI-R-E0-de-a-06-0-UI| U1326| methionyl aminopeptidase II
84		39413| UI-R-A1-eg-e-06-0-UI| M62867| MSY-1
85		39404| UI-R-C2p-qw-a-08-0-UI| M31178| calbindin D28
86		39402| UI-R-AF1-aaq-g-02-0-UI| D76432| EF1 delta
87		39401| UI-R-BT0-qa-h-12-0-UI| U64828| SRC-1
88		39394| UI-R-C3-ty-c-12-0-UI| X15052| NCAM-140
89	transcription factor	39392| UI-R-G0-uh-h-09-0-UI| AF062566| Sp1
90	proteasome	39370| UI-R-E0-bv-f-08-0-UI| D26598| proteasome beta 3 subunit
91		39365| UI-R-E0-bv-d-02-0-UI| D29011| proteasome catalytic subunit 3
92		39358| UI-R-C2p-nt-b-07-0-UI| X65227| NMZ1
93	GPCR	39356| UI-R-AA1-aaa-d-04-0-UI| U15280| Oxytocin Rec
94	GPCR	39351| UI-R-C0-jn-c-07-0-UI| X97121| Neurotensin 2 Rec
95		39334| UI-R-C2p-ns-f-01-0-UI| U88716| Nkx-32 homeodomain prot
96	proteasome	39323| UI-R-E0-cy-e-09-0-UI| D00761| proteasome beta 1 subunit
97	prtoeasome	39321| UI-R-AC1-xw-f-06-0-UI| AF079564| ubiquitin carboxy-terminal hydrolase ubp41
98	transcription factor	39311| UI-R-C1-lq-e-10-0-UI| J04509| JUN-D prot
99		39296| UI-R-C2p-rc-d-02-0-UI| U19597| Cdk4/Cdk6 inhib prot
100		39290| UI-R-C1-kc-d-10-0-UI| U41741| MMUSF (USF)
101		39281| UI-R-C1-kb-d-12-0-UI| AF005885| cyclin G2
102	transcription factor	39274| UI-R-C0-hv-a-09-0-UI| AF065386| Jab1
103		39265| UI-R-Y0-ach-h-07-0-UI| X91753| SEF2
104	polyamine synthesis	39260| UI-R-AC0-yp-f-08-0-UI| D10706| OAZ
105		39254| UI-R-C2p-oh-h-09-0-UI| D29956| UBPY ubiquitin isopeptidase (H. sapiens)
106		39253| UI-R-C2p-ro-d-11-0-UI| AF017182| Sox10
107		39252| UI-R-C0-il-c-03-0-UI| U42556| freac-1 gene
108	proteasome	39236| UI-R-C3-tr-c-02-0-UI| S71381| proteasome beta 4 subunit
109		39212| 101689| 101689| Mouse transcriptional regulator RPD3 homolo
110		39209| 80164| 80164| Rat heavy neurofilament polypeptide NF-H
111		39195| 95418| 95418| Rat non-muscle myosin alkali light chain
112		39192| 476493| M97200| krueppel-like factor
113		39191| 700295357| M92340| IL6B
114		39175| 80186| 80186 Novel
115		39149| 102883| 102883 Novel
116		39140| 701293538| M21948 dihydropyridine-sens Ca channel alpha-2 sub
117		39133| 111979| 111979| Novel
118		39132| 701900803| M81886| glutamate rec type I (HBGR1)
119		39112| 872080| M26745| IL6
120		39111| 100756| 100756| Novel
121		39109| 109519| 109519| Rat PKG binding protein and substrat
122	ion channel	39094| 700771408| L08494| GABA-A receptor
123		39092| 113323| 113323| Rat light molecular-weight neurofila
124		39091| 112184| 112184| Novel
125		39083| 113568| 113568| Mouse neurofilament protein (NF-L) gene, 3′ flank
126		39075| 100749| 100749| Mouse transcriptional regulator RPD3 homolo
127		39068| 112215| 112215| retrovirus-related leucine zipper protein p40 - ra
128		39062| 700773553| AJ225124| hyperpolarization-act cation channel HAC3
129		39058| 112959| 112959| Novel
130		39057| 571654| X61506| E46 for E46 prot
131		39055| 112214| 112214| S-100 beta subunit [rats, Genomic, 423 nt, segment
132		39053| 112025| 112025| Rat ID-A element in the S-100 beta-subunit gene.
133		39049| 101164| 101164| P46783 Human 40s ribosomal protein
134		39025| 1366563| X51405| carboxypeptidase H
135		38988| 700183273| M10244| tyrosine hydroxylase
136		38987| 1972427| D14425| calcineurin
137		38986| 111692| 111692| Novel
138		38973| 113308| 113308| Rat light molecular-weight neurofilament
139		38971| 109491| 109491| Human MUM2 gene
140	apoptosis	38967| 1211267| U67885| p53 binding prot 1
141		38960| 113236| 113236| Rat myelin proteolipid (PLP)
142		38956| 95821| 95821| P09896 Human
143		38955| 95395| 95395| Rat light molecular-weight neurofilament
144		38592| 80905| 80905| Novel
145		38946| 103913| 103913| Novel
146		38945| 95793| 95793| Rat cytoplasmic dynein heavy chain
147		38941| 111147| 111147| Mouse B2 repeat in the 3′ flank of protein 53 (p53
148		38933| 1448814| M25889| Mylein basic port
149	GPCR	38929| 700148588| X66842| Serotonin 2B Rec
150		38922| 41932| U12194| voltage-gated Na+ channel beta-1 sub (SON1B) gene
151		38921| 700280626| S76145| Na/Cl dep neurotransmitter transporter
152		38917| 1364912| U36393| TFEB
153		38916| 477909| U68384| Mrg1b
154		38910| 112963| 112963| Mouse mitochondrial genes coding for three transfe
155		38909| 101166| 101166| Mouse neurofilament protein (NF-L) gene, 3′ flank.
156		38898| 106216| 106216| Horse serpin mRNA, complete cds.
157		38894| 100750| 100750| Sequence 1 from patent U.S. Pat. No. 5457026.
158		38884| 112218| 112218| S-100 beta subunit [rats, Genomic, 423 nt, segment
159		38879| 112228| 112228| Mouse TGF-beta-inducible protein (TSC-36) m
160		38875| 84488| 84488| Novel
161		38865| 1297351| M26657| germinal peptidyl-dipeptidaseA
162	proteasome	38863| 633539| D00763| proteasome alpha 4 subunit
163		38856| 463999| U63858| U57939
164		38845| 84487| 84487 Novel
165		38838| 101073| 101073| Rat PAG608 gene
166		38833| 1210758| AF057691| TCF-3
167		38829| 108622| 108622| ribosomal protein S24 homolog {clone 2-6} [rats, r
168	ion channel	38824| 679093| AF052746| chloride channel CaCC
169		38822| 103933| 103933| Rat gene for testicular cell adhesio
170		38816| 113570| 113570| Novel
171	apoptosis	38808| 111644| 111644| Rat RNA-binding protein SiahBP mRNA,
172	GPCR	38793| 701472025| M64236| Neurokinin 1 Rec
173	GPCR	38789| 402354| AF0279551 GPR27 Rec
174		38787| 111636| 111636| Novel
175		38783| 1211735| Y10926| RBP-L
176		38779| 95446| 95446| Mouse brain mRNA.
177		38772| 1162568| Y076881 NfiX gene
178		38768| 101714| 1017141 Novel
179		38764| 101216| 101216| Bos taurus ribosomal protein 52 mRNA, partial cds.
180		38761| 100721| 100721| Novel
181	proteasome	38756| 100763| 100763| P11661 Rat nadh-ubiquinone ox
182	neuropeptide	38737| 701905916| M10088| dynorphin
183	G protein signaling	38729| 95348| 95348| GTP-binding protein rab10 - rat
184		38725| 102725| 102725| Novel
185	ion channel	38721| 700247271| L08495| GABA receptor alpha6
186	GPCR	38716| 701031976| X63574| Somatostatin 3 Rec
187		38714| 112210| 112210| Mouse LB9 gene, partial sequence.
188		38712| 669616| U89412| PML isoform 1
189		38711| 716499| U90724| X-Proaminopeptidase(eukaryote)
190	GPCR	38710| 700369402| L14618| Calcitonin Rec
191		38701| 1331673| M11597| CGRP alpha
192		38694| 112194| 112194| Novel
193		38676| 701896910| M36418| GLR1
194	GPCR	38675| 701901569| M99376| Adrenergic alpha2C Rec
195		38667| 111664| 111664| Human (clone hh18) protein tyrosine phospha
196		38664| 700133895| 038450| 954 Rec
197		38663| 701921173| M64752| glutamate rec sub (GluH1)
198		38653| 106117| 106117| Novel
199		38623| 113304| 113304| Rat light molecular-weight neurofilament
200		38621| 444406| 444406| Novel
201		38614| 111621| 111621| Novel
202		38605| 108620| 108620| Rat receptor for hyaluronan-mediated
203		38602| 101693| 101693| Mouse ribosomal protein (ke-3) gene, exons
204		38601| 100748| 100748| Mouse transciptional regulator RPD3 homolo
205		38594| 113748| 113748| Mouse necdin mRNA, complete cds.
206	ion channel	38582| 700773668| M81253| Kv3.4 gene
207		38577| 113515| 113515| Novel
208		38558| 66940| 66840| Novel
209		38546| 96780| 96780| Bos taurus clone CSSM015 microsatellite DNA sequen
210		38545| 101138| 101138| Rat ribosomal protein S24
211		38536| 111254| 111254| Human C14orf3 protein
212		38533| 475889| AF020198| PBX2
213		38532| 103937| 103937| Rat heavy neurofilament (NF-H) polypeptide, partia
214		38528| 112216| 112216| S-100 beta subunit [rats, Genomic, 423 nt, segment
215		38522| 463924| T67463| other peptidase (C1A)
216		38508| 66531| 66531| Novel
217		38504| 84486| 84486| Novel
218		38491| 108519| 108519| Rat gamma-smooth muscle isoactin pro
219		38487| 112021| 112021| Rat brain ID transcript, clone bBC2-
220		38469| 95406| 95406| Rat light molecular-weight neurofilament
221		38463| 113514| 113514| Novel
222		38417| 79183| 79183| Novel
223		38404| 1039810| AA297071| Similar to N-methyl-D-aspartate glutamate receptor
224		38402| 701289315| X99792| capacitative Ca entry channel 1
225	ion channel	38386| 700495245| L08493| GABA-A receptor
226		37466| 386514| W65013| Similar to X07384 GLI PROTEIN.
227		37464| 386559| W65005| Mouse cDNA clone IMAGE:386559 5′
228		36393| 387565| A18932401 Similar to L14935 Mouse neural retina-specific leucine zipper protein.
229	ion channel	33| 426170| AA002993| Potassium channel Kv3.4a (Raw3), V-gated
230		2319| UI-R-A0-af-e-06-0-UI| AA817907| Similar to MUSCDPK mouse cyclin-dependent kinase homologue (p130PITSL) mRNA, complete cdsmRNA
231		21709| UI-R-AF0-ya-b-04-0-UI| 988064T6| LVENNOT03 INCYTE
232		21692| UI-R-AC1-xn-e-07-0-UI| 817852H1| OVARTUT01 INCYTE
233		21664| 903057| 580795H1| NMDA channel-like
234	DNA repair	21573| 1054114| 3764982H1| human homologue of yeast RAD23
235	DNA repair	21458| UI-R-E0-ci-a-06-0-UI| 2583919H1| human homologue of yeast RAD23
236		21418| 1348327| 2049923H1| LIVRFET02 U43892 g1 167981 Mouse ABC transporter-7 mRNA, partial cd gb103rod 83 -55
237	DNA repair	21304| 420048| 1676240T6| cell cycle checkpoint rad9 gene
238		21251| 975800| 1275842F6| Eph-Erk
239	ion channel	21230| 748734| 2658404T6| SK2 calcium-activ potassium chann homolo
240		20977| UI-R-02p-np-g-01-0-UI| 485639T6| retinoic acid hydroxylase hP450RAI
241		20971| 2182407| 3369279H1| LON; ATP-Dep Proteas LA
242		20768| 96782| 96782| M58405 R. norvegicus thymosin beta-10 gene, complete cds. 1.0e-72
243		20765| 95816| 95816 X51396 Mouse MAP1B mRNA for MAP1B microtubule-associated 6.5e-99
244	axon outgrowth	20763| 95791| 95791| M16228 Rat neuronal growth protein 43 (GAP-43) mRNA, comp 9.7e-187
245		20762| 95494| 95494| M93056 Human mononcyte/neutrophil elastase inhibitor mRNA 1.9e-117
246		20760| 95467| 95467| U43747 Human frataxin (FRDA) mRNA, complete cds. 1.9e-107
247		20759| 95416| 95416| S77858 non-muscle myosin alkali light chain [rats, Spragu 2.9e-92
248	hsp	20754| 95386| 95386| M11942 Rat 70 kd heat-shock-like protein mRNA, complete c 9.0e-108
249		20751| 95321| 95321| G27093 human STS SHGC-31976. 1.5e-91
250		20749| 95308| 95308| S82024 SCG10=neuron-specific growth-associated protein/st 4.4e-102
251		20748| 94433| 94433| Z92839 Caenorhabditis elegans cosmid T08D2, complete sequ 0.89
252		20743| 84483| 84483| AC003043 Homo sapiens chromosome 17, clone HRPC1067M6, comp 2.9e-31
253	energy production	20740| 83925| 83925| X02231 Rat mRNA for glyceraldehyde-3-phosphate-dehydrogen 7.9e-210
254		20739| 83922| 83922| 569874 C-FABP=cutaneous fatty acid-binding protein [rats, 6.0e-194
255		20738| 83912183912| L37086 Homo sapiens FK-506 binding protein (fkbp12.6) gen 1.9e-151
256		20726| 82552| 82552| D17296 Rat mRNA for polyubiquitin (ten completely repetit 5.4e-90
257		20724| 82519| 82519| M81225 Rat farnesyltransferase alpha subunit mRNA, comple2.7e-164
258		20720| 82475| 82475| V00681 R. norvegicus mitochondrial genes for 16S rRNA, tRN 8.6e-82
259		20716| 82210| 82210| AF014955 Homo sapiens TFAR19 mRNA, complete cds. 1.3e-70
260		20710| 82096| 82096| X14848 Rat (R. norvegicus) mitochondrial genome. 1.0e-99
261		2071| UI-R-AO-at-f-11-0-UI| AA818381| Similar to MMCKIT Mouse c-kit mRNAmRNA
262	axon outgroth	20709| 82094| 82094| X03369 Rat mRNA for beta-tubulin T beta15. 5.7e-105
263		20708| 82093| 82093| G15458 human STS SHGC-16876. 6.7e-51
264		20703| 82047| 82047| M71245 Rat prostatein C3 subunit gene, complete cds. 3.7e-36
265	proteasome	20694| 81776| 817761045249 Rat mRNA for proteasome activator rPA28 subunit al 1.4e-178
266		20693| 81773| 81773| X68273 M. musculus mRNA for macrosialin. 1.0e-134
267		20690| 81743| 81743| X05608 Human gene for neurofilament subunit NF-L. 5.0e-38
268		20674| 80860| 80860| X95591 M. musculus mRNA for C1D protein. 1.7e-77
269		20673| 80835| 80835| AC000083 Home sapiens Chromosome 22q11.2 Cosmid Clone 68a1 0.65
270		20672| 80832| 80832| U16686 Rattus norvegicus defensin RatNP-1 precursor mRNA, 2.9e-117
271		20669| 80637| 80637| X70369 R. norvegicus mRNA for pro alpha 1 collagen type II 2.9e-81
272		20667| 80178| 80178| M58405 R. norvegicus thymosin beta-b gene, complete cds. 6.1e-79
273		20665| 80157| 80157| D83407 ZAKI-4 mRNA in human skin fibroblast, complete cds 1.2e-59
274		20661| 80013| 80013| G27219 human STS SHGC-30611. 2.6e-60
275		20655| 79192| 79192| V00680 Rat mitochondrial genes coding for 16S and 12S rRN 1.7e-109
276		20654| 79184| 79184| J04517 Rat high molecular weight neurofilament (NF-H) pro 5.3e-141
277		20591| 66897| 66897| M80899 Human novel protein AHNAK mRNA, partial sequence. 1.3e-38
278		20590| 66886| 66886| U52828 Human Cri-du-chat region mRNA, clone NIBA2. 2.2e-75
279		20588| 66841| 66841| X51406 Rat mRNA for carboxypeptidase E (EC 3.4.17.10). 2.4e-167
280		20587| 66839| 66839| M15563 Human MHC class II HLA-DR-beta-1 pseudogene (DR7), 0.79
281		20583| 66706| 66706| M30952 Orangutan 28S ribosomal RNA gene fragment. 9.8e-151
282		20582| 66692| 66692| L81910 Homo sapiens (subclone 3_c10 from PAC H74) DNA seq 0.00048
283		20581| 66688| 66688| U49099 Rattus nervegicus cis-Golgi p28 (p28) mRNA, comle 6.8e-193
284		20568| 115932| 115932| M25638 Rat smallest neurofilament protein (NF-L) mRNA, pa 6.7e-157
285		20566| 115916| 115916| X62952 R. norvegicus mRNA for vimentin. 2.8e-167
286		20563| 113752| 113752| AL021308 Human DNA sequence from cosmid U246D9 on chromosom 0.93
287		20562| 113749| 113749| M80840 M. musculus necdin mRNA, complete cds. 1.7e-71
288		20557| 113571| 113571| D28875 Rat mRNA for osteonectin, complete cds. 2.2e-171
289		20550| 113529| 113529| M38194 Rat extracellular signal-regulated kinase 1 mRNA, 2.8e-203
290		20545| 113318| 113318| I00256 Sequence 7 from U.S. Pat. No. 4900811. 1.3e-191
291		20541| 113285| 113285| X76985 R. norvegicus mRNA for latexin. 4.3e-171
292		20540| 113284| 113284| M23984 Rat mitochondrial proton/phosphate symporter mRNA, 2.7e-174
293	ion channel	20536| 113244| 113244| X15466 Rat mRNA for GABA(A) receptor beta-1 subunit. 7.3e-172
294		20532| 113167| 113167| AC002299 Homo sapiens Chromosome 16 BAC clone CIT987-SKA-11 0.84
295		20530| 113155| 113155| U40933 Caenorhabditis elegans cosmid F20D12. 0.38
296		20529| 113063| 113063| AC000399 Genomic sequence from Mouse 9, complete sequence. 6.5e-11
297		20520| 112951| 112951| AC002121 Genomic sequence from Mouse 11, complete sequence. 0.00031
298		20512| 112160| 112160| M14512 Rat Na+, K+-ATPase alpha(+) isoform catalytic subun 1.5e-259
299		20505| 111646| 111646| D28875 Rat mRNA for osteonectin, complete cds. 2.5e-206
300		20501| 111616| 111616| X58526| Mouse DNA for an L1 element. 1.3e-70
301		20500| 111613| 111613| M25888 Rat lipophilin mRNA, 3′ end. 4.4e-125
302		20496| 111441| 111441| U25844 Mus musculus serine proteinase inhibitor (SPI3) mR 1.6e-134
303		20476| 109494| 109494| M38188 Human unknown protein from clone pHGR74 mRNA, comp 2.8e-84
304		20475| 109492| 109492| M26232 Rat peripherin gene, complete cds. 1.4e-1 39
305		20472| 109006| 109006| S80636 injury-inducible gene (ID repetitive element, clon 3.6e-07
306		20471| 109001| 109001| M89646 Rattus norvegicus ribosomal protein S24 mRNA seque 1.6e-80
307		20468| 108618| 108618| L35240 Human enigma gene, complete cds. 2.5e-17
308		20467| 108615| 108615| X55572 R. norvegicus Apo D mRNA. 9.0e-193
309		20464| 108534| 108534| X77953 R. norvegicus mRNA for ribosomal protein S15a. 1.4e-68
310		20455| 106217| 106217| M20480 Mouse brain neurofilament-L mRNA, complete cds. 4.7e-122
311		20448| 106118| 106118| L10426 Mus musculus ets-related protein 81 (2R81) mRNA, c 5.1e-48
312		20443| 105946| 105946| D83407 ZAKI-4 mRNA in human skin fibroblast, complete cds 5.8e-63
313		20434| 105919| 105919| X61294 R. norvegicus L1 retroposon, ORF2 mRNA (partial). 1.5e-92
314		20430| 105905| 105905| D83783 Human mRNA for KIAA0192 gene, partial cds. 3.4e-05
315		20423| 105878| 105878| U13369 Human ribosomal DNA complete repeating unit. 0.021
316		20420| 105801| 105801| D17577 Mouse mRNA for kinesin-like protein (Kif1b), compl 2.5e-122
317		20419| 105787| 105787| X60370 R. norvegicus mRNA for microtubule associated prote 1.2e-97
318		20416| 105774| 105774| U02983 Rattus norvegicus secretogranin III (SgIII) mRNA, 9.0e-82
319		20412| 103932| 103932| M35826 Rat mitochondrial NADH-dehydrogenase (NDI) gene, c 2.0e-78
320	G protein signaling	20410| 103925| 103925| M12673 Rat guanine nucleotide-binding protein G-s, alpha 4.1e-66
321		20406| 103909| 103909| M13100 Rat long interspersed repetitive DNA sequence LINE 4.3e-172
322		20404| 103831| 103831| D90005 Rat endogenous retroviral sequence, 5′ and 3′ LTR. 4.8e-97
323		20403| 103830| 103830| M23953 Rat carboxypeptidase B gene, exons 6, 7, and 8. 1.1e-68
324		20401| 103821| 103821| D10699 Rat mRNA for ubiquitin carboxyl-terminal hydrolase 3.1e-99
325		20400| 103820| 103820| X60469 R. rattus FE65 mRNA for adaptor protein interacting 3.0e-167
326		20396| 103801| 103801| AF043698 Caenorhabditis elegans cosmid C54G6. 0.12
327		20395| 103795| 103795| X70369 R. norvegicus mRNA for pro alpha 1 collagen type II 3.0e-69
328		20391| 103703| 103703| V01556 Rat mitochondrial genome fragment from Sprague-Daw 1.0e-188
329		20385| 102872| 102872| L40632 Mus musculus epithelial ankyrin 3(7kb isoform) mR 1.6e-175
330		20379| 102748| 102748| M16597 Human cytochrome c1 mRNA, partial cds. 2.9e-127
331		20363| 101197| 101197| G05883 human STS WI-6610. 1.9e-65
332		20437| 101132| 101132| M89646 Rattus norvegicus ribosomal protein S24 mRNA seque 6.2e-55
333	hsp	20343| 101112| 101112| M86389 Rat heat shock protein (Hsp27) mRNA, complete cds. 1.2e-147
334		20342| 101108| 101108| X75683 H. spaiens (TL35) mRNA from LNCaP cell line. 1.0e-73
335		20340| 101083| 101083| X79064 V. unguicutata (Red Caloona) AKCS9 mRNA. 0.041
336		20334| 100940| 100940| Z12152 R. norvegicus mRNA for neurofilament protein middle 1.5e-206
337		20328| 100875| 100875| L01693 Rat peptidyiglycine alpha-amidating monooxygenase 3.2e-123
338		20322| 100839| 100839| X96487 B. taurus mRNA, anonymous. 5.5e-09
339	prteasome	20321| 100836| 100836| M29859 Rat proteasomes C2 component mRNA, complete cds. 1.0e-100
340		20317| 100759| 100759| M29341 Rat brain glyceraldehyde-3-phosphate dehydrogenase 2.8e-103
341	apoptosis	20308| 100704| 100704| D17614 Rat mRNA for 14-3-3 protein theta-subtype, complet 3.9e-228
342		20307| 100574| 100574| M22012 Mus musculus synaptosomal associated protein 25 (S 4.3e-72
343		20306| 100573| 100573| L27153 Mouse kinesin heavy chain (Khcs) mRNA, 5′ end. 1.0e-81
344		20302| 100557| 100557| U80954 Caenorhabditis elegans cosmid T07F8. 0.84
345	axon outgrowth	20301| 100465| 100465| X03369 Rat mRNA for beta-tubulin T beta15. 7.3e-91
346		20300| 100463| 100463| X62952 R. norvegicus mRNA for vimentin. 1.2e-114
347		20298| 100455| 100455| U62800 Human cystatin M (CST6) mRNA, complete cds. 8.9e-91
348		20296| 100438| 100438| A08267 Nucleotide sequence for P. falciparum RMA-1 gene. 0.87
349		20295| 100437| 100437| S69874 C-FABP=cutaneous fatty acid-binding protein [rats, 6.7e-160
350		20272| 1065569| Z33905| nicotinic acethyicholine receptor associated 43 kD protein
351		20264| 917438| Z26634| ankyrin brain variant, ANKB
352		20258| 1260365| Z21876| H. sapiens X-linked ALD gene.
353	GPCR	20238| 700123692| Y10148| NTR2 receptor
354		20204| 613665| X96427| Homol. to ScUBC9
355		20127| 921632| X69292| myosin heavy chain. Cell Type:smooth muscle Tissue Expression: GI wall, Respiration
356		20080| 1497875| X61615| H. sapiens mRNA for leukemia inhibitory factor (LIF) receptor
357		20055| UI-R-C1-kp-d-10-0-UI| X57748f properdin
358		20029| 700247749| X54673| H. sapiens GAT1 mRNA for GABA transporter
359		20027| 1244915| X54297| Human mRNA for histidine decarboxylase (EC 4.1.1.22)
360		19976| 700247354| X1S376| Human mRNA for GABA-A receptor, gamma 2 subunit
361		19960| 700247209| X14767| Human mRNA for GABA-A receptor, beta 1 subunit
362	transcription factor	19941| UI-R-BT0-pm-c-04-0-UI| X12740| C-Jun of the transcription factor AP-1
363	neuroptide	1986| UI-R-A0-au-d-10-0-UI| AA818532| Rat gamma-preprotachydinin A mRNA, complete cds
364	neuropeptide	19136| 315382| W12030| U10071 RNU10071 Rattus norvegicus CART protein mRNA, complete cds. Blastn: P. = 8.5e-117
365	proteasome	18970| 931025| U75362| ubiquitin carboxy terminal hydrolase
366	growth factor	18954| UI-R-Y0-mo-d-05-0-UI| U66198| fibroblast growth factor, FGF13
367	apoptosis	18941| 1050567| U59746| Bcl-w
368		18937| UI-R-AG0-xc-h-06-0-UI| U58522| huntingtin interacting protein
369	proteasome	18904| 407454| U44839| A ubiquitin C-terminal hydrolase
370		18871| 700128068| U33267| Human glycine receptor beta subunit (GLRB) mRNA, complete cds
371		18862| 803318| U30509| Gamma Glu Tranterase
372		18856| UI-R-C1-lp-e-07-0-UI| U28807| NFATc3
373		18835| 789552| U20240| CCAAT enhancer binding protein gamma
374	GPCR	18815| 700498633| U16129| Glutamate receptor (GluR4)
375		18784| 1617912| U08107| HSU08107 Human N-methyl-D-aspartate receptor subunit splice variant hNR1N (GRIN1) mRNA, partial cds.
376		1824| UI-R-A0-ar-f-11-0-UI| AA818840| Similar to MMU75839 mouse interferon regulatory factor 3 (mirf3) mRNA, alternatively spliced, complete cdsmRNA
377		18104| 1039340| M9S106| CREB-1
378	neuropeptide	18088| 640127| M88355| MUSOXYNEUI Mouse oxytocin-neurophysin I gene, complete cds.
379		18037| UI-R-C3-ss-b-09-0-UI| M737461 Homo sapiens lutropin/horiogonadotropin reeptor (LHCGR) mRNA, complete cds.
380		17418| UI-R-Y0-acb-c-12-0-UI| R60006| HUMEAR17A Human trilodothyronine recptor (THRAI, ear1), and ear2 genes, last 2 exons each. BLASTN P. 2.8E-96
381		1571| UI-R-A0-bc-d-07-0-UI| AA819345| Rat parvalbumin mRNA, complete cds
382		14951| 700861309| M59980| K Channel
383		14925| UI-R-C0-ie-h-11-0-UI| M55040| Human acetylcholinesterase (ACHE) mRNA, complete cds
384		14871| 492525| M29871| Human ras-related C3 botulinum toxin substrate (rac) mRNA, complete cds
385	G protein signaling	14870| UI-R-E0-da-b-11-0-UI| M29870| Human ras-related C3 botulinum toxin substrate (rac) mRNA, complete cds
386		14866| UI-R-AA0-wp-c-07-0-UI| M29548| Human elongation factor 1-alpha (EF1A) mRNA, partial cds.
387		14866| 299720| M29548| Human elongation factor 1-alpha (EF1A) mRNA, partial cds.
388	axon outgrowth	14839| 338087| M25667| Human neuronal growth protein 43 (GAP-43) mRNA, complete cds
389	G protein signaling	14829| UI-R-C1-lh-b-02-0-UI| M23612| Human GTPase-activating protein (GAP) mRNA, complete cds
390		14817| 349760| M21571| Human platelet-derived growth factor (PDGFA) A chain mRNA.
391		14739| 700124548| L76224| Homo sapiens NMDA receptor mRNA, complete cds
392		14727| 1162580| L42198| MUSALOX Mus musculus arachidonate 5-lipoxygenase (Alox5) gene, complete cds.
393		14677| 1066814| L16510| Homo sapiens cathepsin B A cysteine protease associated with tumor invasiveness and neovascurlarisati
394	GPCR	1467| UI-R-A0-an-d-02-0-UI| AA819622| Rat G-protein coupled thrombin receptor mRNA, complete cds
395	neuropeptide	14620| 482891| K01911| Human neuropeptide Y (NPY) mRNA, complete cds
396		13845| 963216| H58254| monocyte chemoattractant protein 1 receptor (MCP-1RA)
397		13310| 602816| D86323| D86323 Mus musculus mRNA for calmegin, complete cds.
398		13304| 1246629| D83004| similar to Drosophila bendless gene
399	proteasome	13275| UI-R-E0-ct-g-08-0-UI| D23662| ubiquitin-like protein
400		13165| UI-R-BT0-qi-f-04-0-UI| AI145577| Rat degenerin channel MDEG mRNA, complete cds
401	hsp	1278| 1246430| AA823192| D49547 HUMHSP40 Human mRNA for heat-shock protein 40, complete cds. Blastn P. = 3.5E-167
402		12712| UI-R-C2-nf-c-01-0-UI| AI072073| Rat vasopressin mRNA, complete cds
403	G protein signaling	12702| UI-R-C2-nh-g-02-0-UI| A1071860| Rat regulator of G-protein signalling 14 (RGS14) mRNA, complete cds
404		12681| UI-R-C2-my-e-04-0-UI| A1071179| Rat mRNA for cyclinG-associated kinase, complete cds
405		12678| UI-R-C2-ms-b-07-0-UI| AI071095| Rat vgr mRNA
406		1266| UI-R-AO-aq-c-10-0-UI| AA819897| Rat synuclein 1 mRNA, complete cds
407	ion channel	12538| UI-R-C1-kp-b-07-0-UI| AI058645| Rat Kv4.3 potassium channel mRNA, complete cds
408	neuropeptide	12490| UI-R-C1-iz-a-09-0-UI| AI045437| Rat neuropeptide Y mRNA, complete cds
409		12463| UI-R-C1-kd-e-12-0-UI| AI044870| R. norvegicus mRNA for elongation factor 1 alpha
410		12448| UI-R-C1-kc-c-05-0-UI| AI044610| Rat dopa decarboxylase (DOC) mRNA, complete cds
411		12427| UI-R-C1-kb-b-03-0-UI| AI044262| Rat mRNA for thyrotropin releasing hormone receptor, complete cds
412		12350| UI-R-C0-ib-c-02-0-UI| AI030286| Rat brain-derived neurotrophic factor (BDNF) mRNA, complete cds
413		12318| UI-R-CO-iy-b-07-0-UI| AI029599| Rat mineralocorticoid receptor (MR) mRNA, complete cds
414		12263| 659316| AF075599| conjugating enzymes
415	ion channel	12260| 700254638| AF064876| BCNG-1 hyperpolarization NSC channel=HCN1 = HAC2
416	proteasome	12223| UI-R-C1-kt-f-03-0-UI| AF022789| ubiquitin hydrolyzing enzyme I
417		11788| UI-R-C0-ho-b-04-0-UI| AA997314| Rat cDNA clone UI-R-C0-ho-b-04-0-UI 3′ mRNA
418	proteasome	1038| UI-R-E0-cj-b-04-0-UI| AA859300| Rat proteasomes C2 component mRNA, complete cds
419	proteasome	1031| UI-R-E0-cd-c-03-0-UI| AA859229| Rattus norvegicus ubiquitin conjugating enzyme mRNA, complete cds
	C	D	E	F	G	H	I	J	K
1	CA1.CMS	CA1.IMP	CA1.IMPnCMS	CA1.JRF	CA1.JRFnCMS	CA3.CMS	CA3.IMP	CA3.IMPnCMS	CA3.JRF
2	1	1	1	1	1	1	1	1	1
3	1	1	1	1	1.135106383	1	1	1	1
4	1	1.026595745	1.069148936	1.109148936	1.159787234	1.053803876	1.536399576	1.540545753	1.389933468
5	1.283765785	1.117871942	1.152476322	1.417151736	1.500295975	1.098971902	0.830980194	0.88179679	0.923074768
6	0.985121588	1.016195517	1.146686505	1.191468085	1.299080465	1.229552015	1.146405788	0.918101144	1.264264585
7	1	1	1	1	1.154787234	1	1	1	1
8	0.918237765	1.515092312	1.8366709	2.101396894	1.508840481	0.833539644	0.862206007	0.926900775	0.864616587
9	1.271983351	1.490840538	1.058110556	1.17292499	1.134983235	1.184266024	0.98016667	0.86311757	1.142719482
10	0.786262347	0.879611818	1.108889705	1.083839454	1.490824994	0.867116391	1.20458322	1.08546415	1.020460802
11	1.277605055	1.843345703	1.294554207	1.527329255	1.789088356	1.071466291	0.968051399	0.937863052	1.243531068
12	0.580658633	0.857415583	0.803006801	0.723660661	0.930258919	0.927113703	0.854713314	1.140751539	1.097910593
13	0.760842082	0.967954708	1.158522509	0.800087946	0.68949596	0.778530809	0.868427203	0.784918595	0.732258316
14	1	1.955319149	1.436808511	1.609787234	1.482234043	1	1.249255311	1.294361702	1.601808511
15	1	1	1	1	1	1	1	1	1
16	1	1	1.083085106	1	1	1	1	1	1
17	1.68533171	1.843919659	1.306025563	1.025562995	0.761412051	1.042526807	0.870960683	1.147676709	0.991100737
18	0.918452657	1.022825294	1.167341251	1.187777852	1.200384845	1.010731303	1.033229741	0.934244873	0.893184172
19	1.031509395	0.932438571	1.124055338	0.858145777	1.115713401	0.971141137	0.83235423	0.850822441	0.850712293
20	1	1	1	1	1	1	1	1	1
21	1.330920372	1.107606572	1.370217166	1.141388027	1.355883029	1.197396918	1.041212021
22	1.001916525	1.729840999	1.175042589	1.122373651	1.216283362	0.8854339	1.01981501	1.018987818	0.797337946
23	1.168235333	0.868461614	0.829895386	0.880070836	0.817892631	1.282736246	1.151929311	1.217781459	0.648857596
24	0.806988969	1.21877545	1.287776708	1.377952173	1.213148738	0.896036998	0.983004963	1.312265002	0.995262445
25	1.548089532	1.22034818	1.203527018	1.708161881	1.663124576	1.102383239	1.001680874	1.09205787	1.264227398
26	1	1.348191489	1.561276596	1.589361702	1.994787234	0.859468723	0.972812963	0.773545221	0.775103217
27	1.128055186	0.937950837	0.853841305	0.756985783	0.825232859	0.972462265	0.848513654	0.910617583	0.784796636
28	1	1.147340426	1.153297872	1.194255319	1.194361702	1	1	1	1
29	0.929867332	1.0147409	1.260800544	1.333484522	1.522678308 0.83777447	0.778861183	0.844324525	0.689691105
30	1	1	1	1.025	1	1	1	1	1
31	1.113756425	0.948850657	1.197387207	1.197208738	1.221159338	1.064588104	1.141800247	0.889935999	0.918677705
32	1.001651053	0.972291016	0.96317433	1.059976311	0.713398658	0.927060922	1.004460303	0.816130556	0.828514457
33	0.915764112	0.499164687	0.602538896	0.708686116	0.673568888	0.884301786	1.584374032	1.231258816	1.503423126
34	0.707739249	1.05150544	1.265663679	1.446508415	1.305367389	0.958500813	0.900369795	1.187684227	0.844704075
35	1.045635922	1.026555979	1.459111131	1.488602486	1.335229097	0.89865223	1.152229878	1.020670856	1.020784432
36	0.908402292	1.832463399	1.196721833	1.174633991	1.095798854	1.068026865	1.253434415	1.775770835	1.577592348
37	1.113297872	1.338085106	1.106489362	1.1752127661	0.853193351	1.20962379	1.209623797	1.035053952	0.86573345
38	0.942528893	0.933867927	0.855850933	1.025504768	0.825086746	1.132523583	1.276845591	1.315607869	0.995005148
39	1	1.016489362	1.344042553	1.98	1.780212766	1	1	1	1
40	1	1.036595745	1	1	1	1	1.059574468	1	1
41	1	1.036595745	1	1	1	1.030212766	1.249255319	1.164361702	1.174574468
42	0.928423354	0.98207757	1.330933625	1.296577588	1.274000226	0.982149165	1.018675082	0.981466218	0.847396557
43	0.971175085	1.263510529	1.663230747	2.063944927	1.958732145	1.007528423	0.938664374	1.229750645	0.800496799
44	1.205319149	1.418404255	1.882234043	1.958297872	1.946170213	1.118771009	1.02866073	1.150380374	1.142772896
45	1	1	1	1	1	1	1	1	1
46	1.694640812	1.304332372	0.958868133	1.026420757	0.89092058	1.539610003	0.876365457	0.585746033	0.952971924
47	0.806988969	0.966165692	0.875101799	0.891241578	0.886651366	1	1	1	1
48	0.808675141	0.578299043	0.655571572	0.466998646	0.66823921	1.209680851	1.279148936	1.128297872
49	1.00393617	1.378297872	1.120425532	1.146808511	1	1	1.225531915	1.056382979	1
50	0.977017638	0.970886912	0.804162606	0.68296287	0.822554784	1.20317521	1.095218057	0.937222647	1.197092578
51	0.847565517	0.91 4465052	0.857955956	0.990283343	0.852459307	0.896263683	1.098172552	1.211076264	0.840475257
52	1	1	1	1	10.841286042	0.979841796	0.955430807	0.852513396
53	1.303913818	1.909671325	1.164766256	1.036645988	0.906355098	1.062618209	1.006415724	1.339699611	1.61611348
54	0.757270603	0.967695158	1.006767099	1.0963506	1.91976154	0.925404696	0.975864081	0.871518157	0.85773662
55	0.992468022	1.104051685	1.37030063	1.268781248	1.541263554	0.860852567	1.014633884	1.063825972	0.885385843
56	1.534014194	1.104985286	1.897178466	1.681841786	1.43110611	1	1.162234043	1	1.19
57	1.112251548	1.075051591	1.611980015	1.387078672	1.433040078	1.300651235	0.838534071	1.051217998	1.360764155
58	1.228716794	1.700507317	1.103320224	1.328279653	1.77938274	1.21985654	1.040759567	0.719098387	1.170470526
59	0.855115112	1.433010213	1.505452657	2.118660204	1.800501991	1	1	1	1
60	1.412610123	0.900950078	0.74451546	0.867852824	0.806944205	1.325264926	1.402358755	0.86140869	0.801416797
61	1.311790816	1.256009503	1.151183145	1.493967053	1.302397549	1.074979172	1.44027581	1.548198417	0.847455568
62	1	1	1	1	1	1	1	1	1
63	0.672108555	0.643459133	0.567634899	0.538044631	0.730971059	0.812586363	0.48107104	0.695699919	0.606111076
64	1.270667179	1.072979725	0.870984273	0.858300503	0.724304154	1.350444203	1.495203492	1.335179564	1.241996588
65	1.116187147	1.111616026	1.030841624	0.808631353	0.772653939	1.086217209	1.216739298	1.1548744818	1.509356575
66	1.206040951	1.139644221	1.052407361	0.902093608	0.920496632	1.110717409	1.041554839	0.906094509	0.747896626
67	1	1.026595745	1.334361702	1.329255319	1.518297872	0.954445612	0.965428326	0.941457358	0.971158438
68	1.306231353	1.101972009	0.985058336	1.119193732	0.926674267	0.951589282	0.714795487	0.826509354	0.685423155
69	1	1	1	1	1	1	1	1	1
70	1.09787234	1.297978723	1.422021277	1.368510638	1.214148936	0.974358974	0.840080972	0.959598516	0.870023617
71	0.73667584	0.870033722	1.103647428	1.388193341	1.439610062	0.783437291	1.018781504	1.242893641	0.90936083
72	1	1	1	1	1	1.169861203	0.988323419	1.018873467	1.168465888
73	0.919550054	0.871412423	1.397149238	1.447961181	1.35868876	0.711905307	0.395935179	0.997628508	1.119926775
74	1.113297872	1.468617021	2.645851064	1.925957447	1.828191489	1	1	1	1
75	1	1	1	1	1	1.021626754	0.995885642	1.162253402	1.103597426
76	0.745266611	0.966697299	1.095951272	1.072977345	1.518375345	0.938618594	0.888933685	1.018425461	0.96207878
77	0.803854277	1.124274023	0.968585005	0.941789863	0.875065998	0.913779465	0.743553235	0.945420028	0.88482835
78	1	1	1	1	1	1	1	1	1
79	1	1.348191489	1.476276596	1.65106383	1.913829787	1.130332943	1.213485026	1.029780827	1.176008031
80	0.815993416	1.057197723	1.162334545	1.213839929	1.012207668	0.801179065	0.979343864	0.949282211	0.722469736
81	1	1.227659574	1.106489362	1.261382979	1.100851064	0.940328737	1.288229337	1.036690816	0.860091922
82	1.205319149	1.086914894	1.162659574	1	1	1	1	1	1
83	1.128723404	1.488723404	1.683404255	1.755425532	1.679893617	0.97835059	1.334226341	1.065744696	1.177829267
84	1.074490777	0.903780794	0.661228699	0.63659377	0.587068076	0.926811099	0.849338879	0.970202992	1.071450742
85	1.874702466	2.074645339	2.031705227	1.313624679	2.20384652	1	1	1	1
86	0.82265375	1.091805901	1.163259865	0.693965517	0.591317099	0.963163653	0.877351118	0.955191997	0.661595373
87	0.872390104	0.938709533	0.977100265	0.97539401	0.848816847	1.000695998	1.006512553	0.818493661	0.723738504
88	1.173070553	1.422932538	1.421055537	1.505299768	1.080269405	0.951358435	1.001411361	1.004082867	1.182015223
89	1	1	1	1	1.003829787	1	1	1	1
90	0.895325849	1.01030855	0.727458872	0.58253901	0.667372732	1.013615601	0.912508784	1.014757554	0.906711174
91	0.872927371	0.860852982	1.259332143	1.22904899	1.233920047	1.124972175	0.755960401	0.964278601	1.022142815
92	0.723958825	1.042827462	1.095429219	0.826234772	0.887808103	0.86882034	0.832733403	0.7817925	0.731489497
93	1.029948644	1.117212794	1.515504633	1.312953556	1.580258457	1.031693304	0.790571212	0.786977482	0.845410914
94	1	1	1.00893617	1	1	1	1	1	1
95	0.761058688	1.098734177	1.557008055	1.873970081	1.798895282	0.837204421	1.041066182	1.054288513	0.873233525
96	0.988922062	1.071443537	1.171249738	1.1345066	1.240441022	0.97558229	0.657987256	0.818776093	1.146561195
97	1.075671927	1.16947242	0.955673548	0.938729404	0.976900199	0.938490674	0.929714686	0.869700752	0.793779396
98	0.657545256	0.836369551	0.852520188	0.664682919	0.556048835	0.66883818	0.987078894	1.269471638	1.175280737
99	1	1	1	1	1	1	1	1	1
100	1	1	1	1	1	1	1	1	1
101	2.534574468	1.791914894	2.377021277	2.100106383	1.149893617	1.052234043	1.272978723	1.225638298	1
102	0.970764883	1.113230878	0.912029677	0.914090561	0.991197079	0.979423287	0.679807998	0.790915187	1.106977729
103	1.069533217	1.291206663	1.294499322	1.38194848	1.396281232	0.910310631	0.747921832	0.892445676	0.862986729
104	0.781413253	0.921346577	1.193617679	1.30963019	1.237781826	0.960575787	0.856820588	1.183754585	0.886116354
105	0.716472848	0.73642377	0.943828017	0.901418969	0.943561293	0.790140936	0.703069696	1.014737113	1.046849862
106	1	1	1.027446809	1.280638298	1.169574468	0.813003946	0.930777149	1.104906502	1.328272431
107	0.909853812	0.773681233	1.07515677	1.18255493	1.171334809	0.898503448	1.336004044	0.987781498	1.231655555
108	1.159574468	1.468617021	1.62712766	1.915106383	1.881702128	0.802655909	1.251190676	1.214882053	0.925365608
109	1.297292191	1.072732997	1.064168766	1.608816121	1.174370277	0.993515437	1.057442901	1.514690692	1.583725468
110	0.898518949	1.050248333	1.021253747	0.869479619	1.111190657	0.823364076	0.884497145	0.885404772	0.939247548
111	1.039198581	1.060006909	1.023407905	1.083754398	1.250894337	1.107081501	0.903774665	1.112579953	0.989648546
112	0.899995961	1.61775516	1.656326992	1.455551517	1.54965871	1.09641048	1.111062694	1.841004412	1.611253336
113	1	1	2.027340426	1.915106383	1.764361702	1.320956112	0.947481974	1.244819168	1.116220973
114	0.924956775	0.79126469	0.76771619	0.784204526	0.707557571	1.156379727	1.501436978	1.04664477	1.208156562
115	0.990010852	0.685724152	0.39386839	0.351963299	0.34007498	0.914254643	1.332942948	1.266538012	1.277480341
116	1.279818121	1.08722641	1.051354987	0.788260516	0.73980607	0.881632545	0.662625744	0.547455016	0.674119793
117	1.530531915	1.237765957	1.120425532	1.060957447	1	1.472284264	0.714314721	0.755397631	0.636209814
118	0.492816046	0.687731028	0.71479541	0.661245219	0.387965671	0.737833595	0.793485086	1.083516484	0.906357928
119	0.842094228	1.235295839	1.253459659	1.480646388	1.274383405	0.939248014	1.183941689	1.070729131	0.857807773
120	0.945841357	0.881110206	1.308639461	1.236835284	1.318138054	1.037698821	0.970487636	1.145786218	0.898155244
121	1	1	1	1	1	1.008297872	1	1	1
122	1.304477612	1.477698716	1.634276293	2.137556404	1.692693509	1.247583828	0.979847105	0.97412909	1.206998353
123	1.072574911	0.928593195	0.759827324	0.68166582	0.661249365	1.402035969	1.12129284	0.839616559	0.875992535
124	1	1	1	1	1	1	1	1	1
125	1.123349743	1.131237413	0.646229582	0.583240098	0.847560976	1.278923038	1.018803098	0.877529985	0.993065967
126	1.088523159	1.22423789	1.203977308	2.016582507	1.561373979	0.81847162	1.003719118	1.294474453	1.094173382
127	0.843937156	0.696871223	0.851080972	0.718235531	0.762535249	1.033529098	1.093059263	1.133582488	1.098451682
128	1	1	1	1	1	1	1	1	1
129	1	1	1	1	1	1	1	1	1
130	0.973284082	1.30787733	1.588952839	1.857056954	1.571514475	0.824506697	0.907166956	1.067733361	0.867856047
131	0.757563023	0.705827477	0.864667346	0.775994444	0.872005341	1.41784193	1.674934903	1.860488568	1.950646458
132	0.946389999	0.743617655	0.858715877	0.884503784	0.778287269	0.941115776	1.454321987	1.168853371	1.305275403
133	1	1	1	1	1	1.052234043	1	1	1
134	1.162653798	0.772696104	1.009412237	1.2088999	1.029485206	1.033046715	0.886459762	0.94052476	1.035809682
135	1	1	1	1	1	1	1	1	1
136	1.218245301	1.222310795	0.822521244	0.643878641	0.669435454	1.280797706	1.279263656	0.910891749	0.910958447
137	1.00393617	1	1	1	1	1.027405152	0.773598881	0.773598881	0.773598881
138	1.059360983	0.855003046	0.837698654	1.094080514	1.141259206	1.177029353	0.983552896	0.913019435	0.943844377
139	0.911497132	0.77368317	0.791251895	0.654130134	0.823818314	0.932227635	0.888154334	1.004098044	1.015193691
140	0.90812401	0.891906163	0.72520178	0.826582183	0.749490835	1.652701989	1.28250308	1.033004753	0.920700581
141	1	1	1	1	1	0.981415744	1.101900188	1.609835039	1.092190436
142	1.192433644	0.810324026	0.691140986	0.602924279	0.560611283	1.062429696	1.039192469	1.2064413	1.316026286
143	1.269110502	1.038774234	1.062154231	1.316880743	1.556790302	1.110391092	1.052514489	0.859503491	0.947930452
144	0.856820615	0.904993118	0.604985472	0.612020187	0.6512846	1.069870793	0.838038022	0.906674348	1.115710641
145	1	1	1	1	1	1	1	1	1
146	0.688615426	1.023863752	1.057211816	1.103086651	0.990906619	0.782402006	0.7001837	0.723568255	0.599334707
147	1	1	1	1	1	1	1	1	1
148	1	1	1	1	1	1	1	1	1
149	0.909661463	0.452933344	0.323307982	0.328480705	0.313231415	1.054771242	1.299912854	1.091895425	1.282745098
150	0.679777789	0.826000694	1.048013491	0.958732206	1.179405783	1.062556168	1.303950299	0.943578322	1.023248545
151	1.066702128	1.097021277	1.556276596	1.861489362	1.617021277	1	1.075425532	1	1.027340426
152	0.872956909	1.133079495	1.160568351	1.263837296	1.420690936	1.335797509	1.105423865	1.063640016	0.927842507
153	1.384787234	1.107021277	1.125106383	1.090319149	1.047340426	1	1	1	1
154	1.045472142	0.528660307	0.191220794	0.129959906	0.155219135	1.183728226	1.222116734	0.768100388	1.778915215
155	1	1.006382979 1	1.309787234	1.224148936	0.749362245	0.93614477	0.906967474	0.931999362
156	0.966036465	1.172367345	1.386251022	1.953288113	1.911723673	1.058765984	0.865228545	0.868283139	0.77888138
157	1.359417874	1.133930742	0.839394255	0.820638394	0.706401306	1.221036004	1.049131216	0.693883109	1.20093687
158	0.914359991	0.666666667	0.65010974	0.672292186	0.782522534	0.915537096	0.891617897	0.833641684	0.889748914
159	0.95996732	0.95996732	0.95996732	0.95996732	0.95996732	1.107340426	1	1	1
160	0.812916112	0.78985595	0.745430335	0.668623653	0.648650284	0.982563579	0.859828187	0.918601684	0.799523688
161	1.066906067	0.723222723	0.484461484	0.352323352	0.336123336	0.980411103	1.197909346	0.95686929	0.776748067
162	1.057441462	0.992061909	0.768319438	0.674059596	0.697514859	1.290162643	0.804781984	0.775774987	1.031370187
163	1.049487786	1.07537431	1.100630418	1.300197006	1.03715524	1.021503538	1.228573382	1.011726095	1.168131004
164	1	1	1	1	1	1	1	1	1
165	0.861169898	0.920934564	1.096503852	1.026834843	1.241174977	0.951898734	1.113822785	0.990886076	1.169316456
166	1	1	1	1	1	1.47	1	1	1
167	0.954891801	1.116854617	1.066900335	1.283907345	1.072691253	0.852879479	1.236045933	1.093012694	0.864060033
168	1	1	1	1	1	1	1	1	1
169	1.143297381	1.02312565	1.026832866	0.953669682	0.913226134	1.288242644	1.412503173	1.059860599	0.948222339
170	1.015361976	0.889056387	0.96317433	0.9285381	1.017838556	1.119188805	0.962760911	1.222189279	1.21163425
171	0.949585028	1.052400325	1.004621644	1.112839707	1.352318959	0.943605981	0.909129288	0.953421284	0.963447669
172	1	1	1	1	1	1	1	1	1
173	0.809244733	0.67137018	0.993643495	0.714543323	0.628497581	0.886214012	1.150535521	1.273705414	1.205143952
174	1.038813621	0.694870856	0.47736811	0.60890629	0.447567811	1.070269366	1.282583236	1.365651665	1.199933077
175	1	1	1	1	1	1	1	1	1
176	1	1	1	1	1.008723404	1.077168367	1.043128189	0.969945791	0.903300383
177	1.053421952	0.942392695	0.849043926	0.851982579	0.716610268	1.01657117	0.969544233	0.910875475	0.949707964
178	1.468330951	1.329005382	1.253899717	1.191656278	1.296804208	1.178741935	1.117870968	1.263193548	1.116225806
179	1	1	1	1	1	1.40664693	0.897717505	0.897717505	0.897717505
180	0.835792863	0.647303461	0.765830427	0.717131741	0.630533942	0.924014548	1.337658508	1.146662735	0.963629215
181	0.71089242	0.646826338	0.476049324	0.450794404	0.583313572	0.90112099	1.208581368	1.197448782	1.092307692
182	1	1	1	1	1	1	1	1	1
183	1	1	1	1	1	1	1	1	1
184	1.029001223	0.9223112	1.025052831	1.035285285	1.193471249	1.048929332	1.13165782	0.981222692	1.223413859
185	0.817570476	1.040832795	0.978803529	1.023294599	1.116365397	0.933552767	1.32592745	0.936844271	0.927244051
186	1	1	1	1	1.269042553	0.864769686	0.953162417	1.085998028	0.980067615
187	1	1	1	1	1	1	1	1	1
188	1.063953046	1.079342342	0.675696575	0.47336663	0.381360444	0.790765791	0.834488541	0.861307993	0.923968698
189	1.498051682	0.981469003	0.692048518	0.535875425	0.35295324	0.800642081	0.9049803	0.819508433	0.677750214
190	1	1	1	1	1	1	1	1	1
191	0.926143003	0.746786778	0.695827523	0.574912367	0.509159097	1.052888246	1.005588762	0.73724187	0.895906609
192	1	1	1	1	1	1	1	1	1
193	0.523450911	0.511573177	0.59374827	0.459604629	0.308267346	0.679455358	0.785334373	1.003900433	0.961421176
194	1.310638298	1.167446809	1.387765957	1.137340426	1	1	1	1	1
195	0.832679604	0.77595995	1.188996697	1.235858794	1.248916185	0.963345258	1.160694387	0.838484546	0.551287315
196	1	1.086914894	1.181489362	1.407978723	1.559787234	1	1	1	1
197	0.528817246	0.684321627	0.701081047	0.65460884	0.42560609	0.640370597	0.825328701	0.988350705	0.869882145
198	1.082234043	1.066808511	1.14393617	1.213404255	1.169574468	0.924014548	0.924014548	1.329008159	1.31858842
199	1.042959626	0.913580247	0.926537649	1.246774552	1.285035035	1.092721745	0.868602874	0.747171284	1.038147028
200	1	1	1.134468085	1.24212766	1.299148936	1	1	1	1
201	1	1	1	1	1	1	1	1	1
202	1.005078844	1.213863602	0.539412028	0.527931155	0.4428543	0.718916177	0.897902253	1.935078418	1.534295428
203	0.817386245	0.999720703	1.292330967	1.50315373	1.34556034	0.77223517	0.972264921	0.780763954	0.631063949
204	1.437339986	1.061905075	1.004070111	1.467537583	1.062627191	1.075659696	1.22457024	1.421876711	1.537994087
205	1.028540207	0.966445973	0.847399884	0.721604422	0.604229607	1.048020943	1.212753487	1.346461923	0.87520025
206	1	1	1	1	1	1.052234043	1.233404255	1.118191489	1
207	1.382095907	1.459964147	0.789102181	0.59784882	0.668098297	1.071212427	1.335955887	0.813395199	1.017281958
208	0.624969	0.811765289	0.688309112	0.736223402	0.862358018	1	1	1.225638298	1.120531915
209	1.23092352	1.031132816	0.910874684	0.947850353	1.007499782	0.924014548	1.278875455	1.12543006	0.992430945
210	1.357872713	0.740803815	0.457376411	0.457376411	0.457376411	1.00115556	1.122434381	1.225499367	1.163044076
211	1.032804745	1.153371263	0.990134366	1.016704999	1.171952548	1.191763611	0.741461145	0.837040484	0.816333178
212	1.029394351	0.918782433	1.430258071	1.043603942	1.460453453	1.149957647	1.158810831	1.383255458	1.264748477
213	1.158582709	1.270851304	1.339592595	1.049167275	1.359763785	0.869298648	0.848240889	0.719946138	0.802830621
214	0.885686893	0.662813251	0.702280458	0.696579313	0.623706038	0.826568059	1.368826512	1.180771493	1.370717427
215	1.023648373	0.928687923	1.567724048	1.611188127	1.745576123	1.301578444	1.468989158	1.245934311	1.33075574
216	1.353798614	1.428116612	1.141862788	0.985985392	0.991416443	1.150247058	0.874942693	0.900208853	0.99689267
217	1.061753594	0.907326182	1.102734471	1.222449009	1.218859021	0.919472477	0.979107986	0.597810069	0.70122554
218	0.855538585	0.679392549	0.689825126	0.648380781	0.640323373	0.939326565	1.730682104	1.483066253	1.764857231
219	1.006141557	0.869562678	0.98287822	1.128420088	1.118149716	1.309995132	1.510283141	0.997140191	1.036082265
220	1.180192117	1.356409407	1.03516617	1.18758971	1.732527327	1.369763165	0.838092917	0.613000421	0.9531205
221	1.308049259	2.121274317	1.003034089	0.838836338	0.89889345	1	1	1	1
222	0.870579067	0.663469608	0.563481597	0.563481597	0.563481597	1	1.185957447	1.25957447	1.04287234
223	0.840122544	1.192976784	0.63222797	0.404874069	0.564551389	0.800168934	0.772117009	0.734995999	0.805059127
224	1	1.307978723	1.845106383	1.797659574 1.309148936	1	1	1	1
225	2.239912281	0.681641604	1.105451128	1.341353383	0.588972431	1	1	1.017659574	1.213085106
226	1.033286761	0.862862112	0.566213083	0.582815589	0.462763269	0.540268147	0.212409869	0.750362828	0.784963948
227	1.100829611	0.828028079	0.748283344	0.704275686	0.520485003	0.993322596	1.102073686	1.082679015	1.423360848
228	1.163294798	1.124587118	1.481 523534	1.557648637	1.502477291	0.942812803	1.166207565	0.955887488	1.048806984
229	1	1	1	1	1	1	1	1	1
230	1.078369646	1.222019717	1.383646757	1.293761909	1.283655041	0.883856068	0.775236534	0.847575058	0.945988229
231	0.909078328	0.986051527	1.07844935	1.143301965	1.120496586	0.793122044	1.208422909	1.245173844	0.706805081
232	0.780819127	0.722633521	0.753152664	0.641739682	0.759763635	0.7363115	0.633987323	0.668035014	0.637971627
233	1	1.448510638	1.310212766	1.407978723	1.410531915	0.971375426	1.20584892	1.227756536	1.496951535
234	1.052363039	1.321874865	1.34669434	1.253599689	1.815583517	1.151781583	1.071263304	0.840898574	1.015985865
235	1.068432876	1.04115998	0.813322689	0.846573715	0.783636262	1.042087502	0.837145956	0.904013499	1.252139327
236	1.037959585	0.862685939	0.905697446	0.968074656	0.94716531	0.962774869	0.830314136	0.916439791	0.818167539
237	0.912105954	1.128064799	1.217053415	1.281414186	1.338879159	1.029201937	1.158429749	0.952241896	0.903116105
238	0.897803152	0.860543536	0.491553152	0.426382212	0.402978098	1.152399086	0.996572734	0.964737243	1.114166032
239	0.984156363	1.410824017	1.681868661	2.018731028	1.678759162	1.005047374	1.184229169	1.115691136	1.153280793
240	1.09787234	1.076914894	1.632234043	1.568829787	1.329361702	1	1	1	1
241	1	1	1	1	1	1	1	1	1
242	1.085456528	0.808631572	0.443243779	0.385843164	0.335910908	1	1	1	1
243	0.474956212	0.244652986	0.15105012	0.15105012	0.15105012	0.985961885	0.752293938	0.859736491	0.790212532
244	0.749535508	0.766205615	0.811725846	0.816061107	0.557855078	0.833762193	0.701773283	0.91372948	0.865657351
245	0.931560462	1.593677873	0.875388861	0.751756147	0.822779729	1.170018282	1.144777968	1.594090936	1.870672878
246	1.00393617	1	1	1	1.219148936	1	1	1.009893617	1
247	1.09375593	1.13125	1.04147889	1.074881404	1.348031309	1.08893192	0.944019605	1.237459932	1.159473563
248	1	1	1	1	1	1	1	1	1
249	1.154396891	0.877249015	1.097546045	0.910039391	1.034334079	1.022269591	1.018539294	1.081365345	0.994951478
250	1.327738319	1.323613721	0.842500876	0.76758926	0.848186132	1.410320822	1.130753128	1.118124726	1.481933694
251	0.983422447	0.677935987	0.658416455	0.705227797	0.650053303	0.962922931	1.671628836	1.18173332	1.488732763
252	0.93067653	0.976375134	0.973034244	0.931690729	1.100465338	1.175323686	1.116222391	0.866488957	1.211805027
253	0.893510825	0.90358757	0.990079795	0.680674967	0.77977667	0.98782554	0.928453796	0.892709361	0.943366422
254	1.007696887	1.260588535	1.106225549	0.97763225	1.585005953	1.047746076	0.967022346	0.847637826	1.028802289
255	0.95629276	0.952256731	1.240192942	1.432298076	1.103214057	1.010490694	0.845211506	0.78463621	0.73258832
256	0.940914436	0.772238056	0.836027345	0.884220597	0.773962091	0.917123921	0.680502466	0.643071825	0.688840937
257	0.717037778	0.718330414	0.820323576	0.780335251	1.05545826	0.915473068	0.889919978	1.158429157	1.473135633
258	0.827142324	1.223205852	0.482600004	0.365173648	0.277121455	0.626066413	0.631771449	1.463429146	1.363302271
259	1.450548454	1.037621249	1.270691687	1.310851237	1.094189103	0.995043325	1.056689675	1.305845205	1.172602438
260	0.68085961	0.822454308	0.430541608	0.381803575	0.566847426	0.727926837	1.346109878	1.41846547	1.374016542
261	1.082234043	1.318085106	1.14393617	1.339042553	1.264042553	1.254870024	1.299302886	0.89009056	0.980975959
262	1.274563782	1.018547098	1.261133125	1.134223149	1.103524505	1.157578383	0.926551828	1.112371306	1.081811215
263	0.909432403	0.848164983	0.936290898	0.979827955	0.952819203	0.943419724	0.872366207	0.719320094	0.749175362
264	1.037586117	0.923955699	0.880265109	0.863172582	0.987180605	1	1	1	1
265	1	1	1	1	1	0.991665788	0.991665788	0.991665788	0.991665788	0.991665788	0.991665788
266	1	1	1	1	1	1.052234043	1	1	1
267	1.097622028	0.784313725	0.784313725	0.784313725	0.784313725	1.647169473	1.847456109	0.841992118	0.871551415
268	0.772090308	0.59366485	0.603688206	0.712874659	0.53946088	1.132725528	0.733829175	0.883661228	0.807653551
269	1.056918029	0.864447781	0.522800578	0.383633634	0.348793238	1	1	1	1
270	1	1	1	1	1	1	1	1	1
271	0.927421184	1.250829914	1.284830615	1.318522031	1.037526547	0.904151499	1.076046265	1.148994398	0.779787262
272	1.450062628	1.186927286	0.796591733	0.501977718	0.382358758	1	1	1	1
273	0.887386355	1.184964474	1.164871266	0.940637176	1.565665826	1	1.027978723	1	1.159148936
274	1.066702128	1	1	1	1	1	1	1.009893617	1
275	0.736158355	1.102046521	0.518562318	0.511823721	0.350187709	0.539720226	0.8203125	1.899023036	1.805553773
276	0.893111978	1.055275426	1.183093902	1.038340786	1.282656265	0.791386594	0.914662983	0.822577646	0.869497064
277	1.195298557	1.136250064	1.120442609	1.199326908	1.394013564	1.00199636	1.001878927	0.900504962	0.849715225
278	0.744456918	0.796449621	0.934675835	0.928641594	0.87349144	0.977403055	0.806563334	0.88735593	0.733151649
279	0.951944381	0.780579112	1.546413019	1.886469555	2.055924822	0.951061399	0.778633864	0.737001514	0.710752145
280	0.891596639	1.191848739	1.309495798	1.495798319	1.92302521	1.023048011	0.912062974	0.93872775	1.113254379
281	1.020361132	1.788011062	1.234247912	1.277437371	1.208355927	1.241904353	1.069568947	2.032897276	2.051168775
282	1.096576873	0.878720151	0.905246442	0.856134572	0.99011881	1.003133789	1.371313781	1.545198875	1.540136601
283	0.91711175	0.936010682	0.905901514	0.777181888	1.111940956	0.848944297	1.274967896	0.838378995	0.829428526
284	1.27883885	0.939880629	1.500759831	2.126424308	2.540314704	1.060498021	0.769522272	0.597972935	0.630318523
285	0.752120339	0.752120339	0.752120339	0.752120339	0.752120339	1	1	1	1
286	1.064377811	0.904317841	0.694002999	0.648215892	0.716131934	0.898512686	0.858899582	1.092592593	1.098911247
287	1.098424169	1.135208079	0.672079053	0.512188752	0.614966046	0.974699685	0.788604792	1.148882625	1.112609892
288	0.916783165	0.69163417	0.89163417	0.69163417	0.69163417	1	1	1	1
289	1	1	1	1	1	1	1	1	1
290	1	1.066808511	1	1	1.066808511	1.065302247	1.482962338	1.780778653	1.437809896
291	1.074103272	0.926290895	0.926290895	0.926290895	0.926290895	1.070428475	0.792847503	0.792847503	0.802041161
292	1.195830005	1.091287568	1.756911548	1.484702891	1.715976731	1.019646441	0.853040293	1.058034719	0.982876254
293	0.822771403	0.722241836	1.126345984	1.85423654	2.012842012	0.991082134	1.120690947	1.039418465	0.883917866
294	0.85695247	1.22848385	1.174432884	1.355557883	1.445763406	0.870942884	1.052566039	1.003735783	0.933594304
295	1	1	1	1	1	1	1	1	1
296	1	1	1	1	1	1.36455676	0.749362245	0.749362245	0.749362245
297	1	1	1	1	1	1	1	1	1
298	1.211243612	0.8459682	0.929230551	0.899985804	0.82673197	1.130572065	1.00083581	0.955980684	0.944372214
299	0.897078384	0.633169747	0.64289318	0.779617484	0.925744164	1	1	1	1
300	1.164877471	0.695935441	0.695935441	0.695935441	0.695935441	1	1	1	1
301	0.751753106	1.025949525	0.479122913	1.514968142	0.658420247	1.413864344	1.681170936	1.516655012	1.229928167
302	1	1	1	1	1	1	1	1	1
303	0.922592958	0.752951786	0.941509553	0.931275297	0.872512216	1.005249908	1.024560973	1.220864546	1.240359818
304	1	1	1	1	1	1	1	1	1
305	0.834813642	0.620654811	0.670333019	0.757182669	0.68153658	1.074743563	1.8983562	1.406631048	1.683992032
306	1.062001532	1.156851259	0.752579642	0.664488803	0.529040689	0.958388713	1.315100705	1.008553999	0.756159902
307	0.804019765	0.743956998	0.910590278	0.718215812	0.744825053	0.825699074	0.778742386	0.912417862	0.814283659
308	0.889202541	0.794424841	0.663373324	0.663373324	0.805434016	1.285494803	1.000813376	0.849525531	0.849525531
309	0.916009251	1.140251151	0.78580846	0.678085893	0.618734735	0.894159197	1.13729128	1.160851197	0.951561347
310	0.945361505	1.110817652	1.025118301	1.233602949	1.674947728	1.593465288	0.937869895	0.590813094	0.984767605
311	0.846784554	0.92080405	0.947933197	0.908788634	1.189904028	1	1	1	1
312	1	1.157340426	1.167446809	1	1.269042553	1	1	1	1
313	0.893744644	0.732258316	0.732258316	0.732258316	0.732258316	1	1	1	1
314	1	1	1	1	1	1	1	1	1
315	0.725557726	0.573815154	0.828364347	0.843117097	0.901408451	0.938459105	0.752649897	1.602990033	1.599588673
316	0.704719559	0.608078427	0.611614078	0.659559651	0.586489527	0.871253189	0.811782526	1.947464923	1.662547832
317	0.547753627	0.547753627	0.547753627	0.547753627	0.547753627	0.821625372	0.464141394	0.514143434	0.632066615
318	0.98698026	0.98698026	0.98698026	0.98698026	0.98698026	1	1	1	1
319	0.842217184	0.72088364	0.918718476	1.052898895	1.386724311	0.801346986	2.147474858	1.213437004	0.811440253
320	0.795805269	0.725196806	0.58112371	0.442720323	0.489243186	0.931445375	1.010020487	0.704388667	0.54754505
321	1.260029718	1.185642645	0.872956909	0.872956909	0.872956909	1	1	1	1
322	1	1	1	1	1	1.259777645	0.933095096	0.933095096	0.933095096
323	1	1	1	1	1	0.990589198	0.961538462	0.961538462	0.961538462
324	0.860478947	0.74707163	0.987596241	0.849944247	1.196378697	0.79318267	0.884489897	0.895059709	0.682514738
325	0.695810831	0.809243176	0.423277624	0.350788206	0.347704715	0.753281088	0.57437919	0.651449344	0.611533377
326	1.111037863	0.843761644	1.208117172	0.803147124	0.745306544	0.700875458	0.72222288	0.94451684	0.705963536
327	1	1.237765957	1.267021277	1.251702128	1.528617021	0.924825477	0.561818497	0.542318122	0.542318122
328	0.753382865	0.88546714	0.777287247	0.734611105	1.259323068	1.011495164	1.233272554	0.86629935	0.846123355
329	0.845399766	0.850795935	0.845399766	0.845399766	0.845399766	1	1	1	1
330	0.807253202	0.875614715	1.101360627	0.987245208	1.239821363	0.98258426	0.839732231	0.991945444	0.931178292
331	1	1	1	1	1	1	1	1	1
332	0.95894405	1.071355398	0.633018125	0.596217494	0.51678487	0.92859352	1.474251914	1.525632104	1.015193691
333	1	1	1	1	1	1.151595745	1	1	1
334	1	1.147340426	1.200425532	1.915106383	1.349574468	1	1	1.195	1.066276596
335	1.144148936	1.016489362	1	1	11.053385883	0.841992118	0.841992118	0.841992118
336	0.738508576	0.725190444	0.577861844	0.657045137	0.79022646	1.153766545	0.933656517	0.942099243	1.453292663
337	0.994606244	1.223287512	1.130370457	1.100675676	1.101432898	0.906604403	1.021347565	1.093087699	1.201390671
338	1.407893579	1.511469303	1.246296677	1.131332316	1.510948637	1.344494932	1.005867873	1.0126998	1.154036493
339	0.881003174	1.216140278	1.126801603	1.604193767	0.972995473	0.777144325	1.039856189	1.49424756	1.006111967
340	0.796981774	0.955322072	0.803578539	0.739228691	0.611884939	0.840370584	1.049907548	0.982337212	0.754849585
341	1.105339757	0.98067851	1.196627522	1.25529459	1.161648098	0.969927956	1.024861701	0.830792487	0.908079249
342	1.028626129	0.864802843	0.739283232	0.687276256	1.202402339	1.212553588	0.934395766	0.704579908	0.836261091
343	1	1	1.139255319	1.378404255	1.264042553	1.104368634	0.576757884	0.636028961	0.673027365
344	0.844010727	0.922973778	1.047675805	1.266239571	1.276445173	0.857194966	1.145540762	1.096480029	0.933977749
345	1.210310049	0.749700175	0.931069736	0.789729273	0.650138608	1.307980883	1.396076366	1.347191531	1.169073436
346	0.996290408	0.996290408	0.996290408	0.996290408	0.996290408	1	1	1	1
347	0.902544407	0.902544407	0.902544407	0.902544407	0.902544407	0.855700245	0.717733496	0.922914262	0.892630193
348	1.007508005	1.284807331	1.227669206	1.251628575	1.476758308	1.050151238	1.046603682	1.041188991	1.062287613
349	0.933836019	1.005468782	1.093632183	0.974437585	1.194928947	0.99657444	0.853637828	0.877001903	0.962377397
350	0.725987211	0.950029666	0.880908432	0.863306744	1.174500626	1.046633711	1.390699506	1.022879391	1.07187541
351	0.823974788	0.784138514	0.573965179	0.37737807	0.358372728	1.013015991	1.444987515	1.391010997	1.1788397174
352	1	1	1	1	1	1	1	1	1
353	1	1	1	1	1	1	1	1	1
354	0.837285432	0.856885046	0.57266966	0.441264112	0.57061317	1.044607654	1.063548512	0.984847313	0.864785466
355	0.858909796	1.107081902	0.782738785	0.869276639	0.661265513	0.924901634	1.173463983	1.072204146	0.884269068
356	1	1	1	1	1	1	1	1	1
357	1.209906618	1.425091352	1.420567252	1.618989618	1.321269068	0.819803643	0.800776159	0.723681543	0.679139274
358	1.372111276	1.527339322	2.244789396	2.209296241	2.656492544	1.486865851	1.680770002	1.341387608	1.04882695
359	1.1441 48936	1.227659574	1.219361702	1.146808511	1.43606383	1.459336571	1.460369949	1.078743412	1.058385863
360	1.260572544	1.079279728	1.208523097	1.130123617	1.139289678	0.976833525	0.944053353	0.856516059	1.056005148
361	0.914475635	0.960734407	1.959251754	2.446130276	3.190718592	0.955225873	0.888655823	0.876527908	0.944375584
362	1	1	1	1	1	1.115842764	1.04030176	1.214909668	1.060055589
363	1	1	1	1	1	1	1	1	1
364	1.29470332	1.043779055	1.052783777	1.013836524	1.067608624	1.092970791	1.215625742	1.018522916	1.133341249
365	1	1	1	1	1	1	1	1	1
366	1.455028644	1.493984723	1.907893062	2.259707193	2.132972629	1.227277286	1.252197894	1.144041451	1.218017717
367	1.123284092	1.093721692	2.001515574	1.774719532	1.847083827	1.072928038	1.078022461	1.104736809	1.287508627
368	1	1	1	1	1	1	1	1	1
369	0.946656217	0.855067921	0.992998955	0.977742947	1.006321839	1.08752992	1.046228939	1.192518891	1.09729197
370	0.918603277	1.081508961	0.869176876	0.786752283	0.844342576	0.835062886	0.986209094	0.910495653	0.860968246
371	1	1	1	1	1	1	1.122765957	1	1.035106383
372	0.604395604	0.832444255	0.943828017	0.594100075	0.730395818	0.971375426	1.052288933	1.123592022	0.971375426
373	1	1.458617021	1.729893617	2.166276596	1.622234043	0.868360277	0.88594204	0.922446547	0.79557476
374	1.198828842	1.633765645	1.134291429	1.040640013	0.929153178	1.227704371	1.080964135	1.000726006	1.366429505
375	0.80751082	1.649109961	0.706287221	0.98174363	0.75018712	0.950673593	0.877401917	1.168503737	1.324549179
376	1	1.026595745	1.101808511	1.071595745	1.299148936	1	1	1	1
377	0.987031033	1.059918312	0.774601036	0.787991073	0.625584235	1.081811942	1.0061312	0.848318463	0.776801647
378	1	1	1	1	1	1	1	1	1
379	1.757057732	1.524372375	1.607599883	2.194099834	1.796913158	1.044602359	1.181811309	1.022074388	1.1005443
380	1.085181027	1.141664328	1.530592198	1.747544204	1.749929834	0.876528202	0.724228952	0.951132259	0.875382051
381	1.077035455	2.262628533	2.349159971	1.423498342	3.175591392	1.138477157	1.093739425	0.696717428	1.340169205
382	0.696719182	0.592457328	0.864962332	0.733225348	0.445683898	0.692066806	0.578249439	0.879803603	0.822546973
383	1	1	1	1	1	1	1	1	1
384	1	1	1	1	1	1	1	1	1
385	1.329587063	1.207282343	1.167743084	1.277817331	1.179287022	0.947535936	0.971063635	1.130265649	0.998044559
386	0.713741987	1.383847489	1.496961806	1.580328526	1.124031784	0.970026047	0.996273292	1.206050892	0.82163895
387	1.0696199	0.940630567	0.646307385	0.609649518	0.50391 6897	0.964072134	0.957726463	1.017279482	0.880093503
388	1.057379261	1.258566418	1.13625326	1.107293821	0.922475043	1.109041969	0.759448473	0.876235992	1.105581191
389	0.9527833	1.466302187	1.472962227	1.699502982	2.160636183	0.684930614	0.867092319	1.131409212	0.878624015
390	1.050503077	1.107648725	1.964051968	1.951304093	1.820504054	1.043136815	1.088685701	1.066584394	1.410865541
391	1	1	1	1	1	1	1	1	1
392	0.972771971	1.009784009	0.89233875	0.772218369	0.689871693	1.107698795	1.115169403	0.833816162	0.883223374
393	0.945964957	0.828494692	0.999552372	0.888284947	1.202327663	0.788267288	1.310929811	1.066045066	03873219373
394	0.912976399	0.646735051	0.607997665	0.563547661	0.646109582	1.044526627	1.178550296	0.884023669	0.827366864
395	1	1.197553191	1.069148936	1.203829787	1.219148936	1	1	1	1
396	2.3688923	1.674597084	2.028651829	1.500724823	1.34228703	1
397	0.779081559	0.771886619	0.636583128	0.516248974	0.594234391	0.869260978	0.806640486	0.858550518	1.064976794
398	1.233835317	0.965735459	0.76583451	0.714877928	0.549846837	1.068628613	1.055159003	1.114515402	0.989921506
399	0.749524107	1.038099838	1.050629315	1.128903032	0.976674148	0.740349876	1.031343094	1.245832541	0.988478798
400	1.00393617	1	1	1	1	0.95106214	0.933095096	0.942326782	0.933095096
401	1	1	1	1	1	0.915109034	1.099785826	1.135611371	1.088979751
402	1	1	1	1	1	1	1	1	1
403	1.069885467	1.267197037	1.32096564	1.346821206	2.635141623	1	1	1	1
404	1.265744681	1.318085106	1.276595745	1.137340426	1.400319149	0.91260732	1.162313601	1.164121103	1.199367375
405	0.93105365	0.89535554	0.667579363	0.797854819	0.87573599	0.80516226	1.367121915	1.319978699	1.481142714
406	1.059814742	1.444225463	1.63618447	1.684765471	1.663874655	0.698933441	1.009990549	0.939966698	0.716034382
407	1	1	1	1	1	1.134733158	1.102686789	1.202158064	0.940507437
408	1	1.65	1.422021277	1.630425532	1.590957447	1	1	1	1
409	1.064658712	0.940849521	0.601602803	0.609297357	0.493831628	1.044193225	0.886810354	1.012792994	0.936267378
410	1	1	1	1	1	1	1	1	1
411	1	1.700531915	1.62712766	1.203829787	1.244042553	0.75011262	0.731771671	0.856425767	0.913894073
412	1	1	1	1	1	0.915473068	0.884876605	1.069665792	1.07477641
413	0.908472699	1.063661535	1.630302359	1.807043969	1.816303024	0.925202382	1.018097277	0.8358868	0.864253696
414	1.034842773	1.156067448	1.021419398	0.754236235	0.77263123	0.894804872	0.90857569	0.873626647	0.783942332
415	0.988227503	1.029651976	1.014200574	0.987565301	1.025163711	0.946519482	1.192247593	1.241897273	1.097232723
416	1.412992323	1.151487096	1.450487984	1.26459129	1.143849092	1.063879148	0.86366334	0.987510116	0.96870785
417	1.369501466	1.479301644	1.4231057761	1.502966651	1.729864284	1.012023414	1.040895428	1.058297738	1.162790698
418	0.924456655	0.913846635	0.973419107	1.008867743	1.115437021	1.084594445	0.802897481	0.99531697	1.081941497
419	1.395025189	1.39697733	1.161649874	1.127267003	1.570528967	1.252402789	1.20993781	1.042967523	1.106476537
	L	M	N	O	P	Q	R	S	T
1	CA3.JRFnCMS	DG.CMS	DG.IMP	DG.IMPnCMS	DG.JRF	DG.JRFnCMS	DR.CMS	DR.IMP	DR.IMPnCMS
2	1	1	1	1	1	1	1.103871183	0.617720674	1.7585750042
3	1.101702128	1	1	1	1	1	1.038510638	1	1.33893617
4	1.257255809	0.740795287	0.490586315	1.034191776	0.374159137	0.422282371	1	1.751382979	1.157340426
5	1.018895145	1.124839329	1.056286399	0.595109256	0.434105083	0.722662139	1	1	1.275319149
6	1.076125307	0.947703704	0.913407407	0.791679012	0.499975309	0.848493827	1.030540614	0.979168566	1.287218525
7	1	1	1	1	1	1	1.795	1	1.747234043
8	0.780506873	1.005395324	1.02511157	1.157130487	2.296542996	1.414707254	0.850643131	0.643130816	1.264709907
9	1.028533628	1.245547349	1.435157589	0.750773905	1.005658503	1.609455315	1.310610406	0.983449406	1.728029496
10	1.296049205	0.909671324	1.098173385	1.005611544	0.395613834	0.859883188	0.93899243	1.356720584	1.052475042
11	1.209910227	1.102421181	1.073419265	0.868663996	1.356906462	1.175492075	1	1	1.444042553
12	1.033041788	0.977387705	1.114211252	1.104783075	1.908860954	1.592595432	0.952665424	0.940070774	1.245576652
13	0.762561346	0.930115128	0.904009291	1.099222379	2.517521713	1.876792567	0.855400855	0.855400855	1.154336154
14	1.734574468	1	1.118617021	1	1.101382979	1.290638298	1	1	1
15	1	1	1	1	1	1	0.908032299	1.063790905	1.335826604
16	1	1.117156016	1.224620994	1.366628286	1.864901171	1.888025331	1	1	1
17	0.848712525	1.313788228	1.65324801	1.495051715	0.699456805	1.055435672	1	1	1
18	0.79125751	1.102656637	0.99721727	1.191921388	1.466324623	1.098612983	1.492798403	1.44241099	1.883681133
19	0.9074754	0.994816529	0.892904208	1.484229947	2.387178962	1.270682637	1.120951499	1.007371898	1.140327908
20	1	1	1	1	1	1	1	1	1
21	1.009797653	0.900424854	0.836453355	0.65582404	0.687975748	0.960125686	1.037447823	1.260405486	1.661359571
22	0.782862085	1.014555168	0.898386393	0.59043829	0.664467946	0.867913214	1	1	1
23	0.648857596	0.953076976	0.71825695	0.498019261	0.394132914	0.859640735	1.326096913	1.654850234	1.37849226
24	0.962024365	1.059982914	1.002867952	1.034720527	1.669270198	1.217415182	0.914840368	0.679586039	1.028239989
25	1.064983792	1.03853491	1.10754483	0.700925219	0.448302175	0.908098054	1.023243802	1.596177686	2.061363636
26	0.839760069	1	1.064468085	1.343191489	1.043723404	1.101808511	1.017888428	0.907791609	0.866758875
27	0.974536237	0.981601926	0.984871896	1.182687125	0.736030759	0.962485177	0.809792361	1.265316585	1.168332906
28	1	0.92055089	0.932014489	0.551247861	1.781395534	1.306452255	1	1	1
29	0.796315594	0.983527178	1.00517446	1.193543793	2.059340138	1.289627344	1.125736016	0.947767419	0.916192345
30	1	1	1.041914894	1	1.262234043	1.164468085	1	1	1
31	0.993247607	0.979115939	0.991477805	0.943669226	0.877692452	0.895813823	0.934879271	0.989362301	0.509070749
32	0.834916304	1.101290442	0.799147938	0.52713633	0.650469252	0.750864411	1	1	1.036382979
33	1.314308322	0.978795776	0.634663741	0.346984867	0.267160426	0.228436886	0.924531516	1.539449988	0.599075201
34	0.997838398	1.0127772	0.841037547	2.02838844	2.520246578	1.609735009	1.045008578	0.669884546	1.187601428
35	0.750170364	1.029442818	0.910687719	0.320223641	0.580097903	0.617651293	1.180385257	1.293498796	1.52604186
36	1.797649333	1.005809468	1.443017292	1.327327191	1.616121273	1.97816911	1.115050505	1.098080808	1.15
37	1.248002333	0.865833034	0.676574591	0.555065854	0.730589863	0.687285399	1.110205584	1.056522425	0.619801251
38	0.933202549	0.994965969	1.02648747	0.358184612	0.381018097	0.669761315	1.313651465	1.715795832	1.195560254
39	1	1	1	1	1	1	1	1	1.370531915
40	1.161808511	1	1.050957447	1.679574468	1.331170213	1.155531915	0.990388874	1.193506954	1.026175923
41	1.154255319	1	1	1	1	1	0.84125852	0.929069583	1.270486606
42	1.130372324	1.088880213	1.216637387	0.761663088	0.503253302	0.952176459	1.140636669	0.991971621	1.410380881
43	0.964555269	1.087534527	1.094983516	1.139623986	2.057881137	1.287570168	0.851992262	0.622359447	1.026224767
44	1.088105207	1.001698754	1.140713477	1.284470555	1.102774632	1.176741223	0.917400475	0.898717648	1.399872769
45	1	1	1	1	1	1	1	1	1
46	0.640959028	0.883288006	0.805451901	1.080661143	1.038032593	0.978664643	0.904647275	0.866599799	1.907255099
47	1	1.141220994	0.936161737	0.936161737	0.936161737	1.132158152	1	1	1
48	1.221914894	0.524964809	0.308334023	0.235385443	0.194584748	0.194584748	0.908479747	1.426247105	0.531043444
49	1	1	1	2.93712766	1.147340426	1.110744681	0.904063366	1.29082812	0.919411913
50	1.26855394	0.961353586	1.132666795	0.795103506	0.602448247	0.815740563	0.9290144241	1.304266607	0.735784204
51	0.921338319	0.949799826	0.827554395	0.384386423	0.414482158	0.579704091	1.335097181	1.533123028	1.127709372
52	0.862805137	1	1	1	1	1.048297872	1	1	1
53	1.873187465	0.83237586	1.050848805	1.829573013	2.421699201	1.748479307	0.965321312	0.839864447	1.059010902
54	0.889018521	1.385040716	1.452297175	1.558158239	1.861264703	1.60058309	1	1.141170213	1.058723404
55	0.902404907	1.017979241	1.110946712	0.822068285	0.992108862	1.093415832	0.93772513	1.116395764	1.230515582
56	1.266914894	11.118617021	1.238510638	1.400425532	1.173404255	1	1	1.243297872
57	1.018685111	1.06132114	0.905813669	1.641504042	2.376071691	1.701804524	0.900267514	0.8663894	1.580902023
58	0.957543427	1.540170671	1.614326517	0.984439889	1.407366521	1.487480068	1.225028681	1.010436327	1.339310166
59	1	1	1	1	1.043723404	1	1.012591815	0.896689879	2.08976438
60	0.91881406	1.055205521	1.353285329	0.726372637	0.669166917	1.401390139	0.849832746	1.385317783	1.001898563
61	1.338031102	1.46948589	1.50828456	0.520182453	0.449564477	0.970791086	1.008471074	1.108161157	1.186570248
62	1	1	1	1	1	1	1	1	1
63	0.831556503	0.810053109	0.741246416	1.605278	1.305329699	1.113878836	0.989600682	1.066526785	1.047223133
64	1.442209274	0.953370052	1.090596014	0.651979313	0.312010272	0.780301667	1.280011857	1.190470309	0.865724731
65	1.145988208	0.796242658	1.063641807	0.667988155	0.253919966	0.595171443	1.04457325	1.459991306	0.902825677
66	0.802644673	1.168877343	0.996664722	1.553138794	1.990445474	1.261967924	0.93901366	0.788840985	0.742966499
67	1.171043835	1	1.141382979	1	1.020638298	1.137553191	1.219148936	1.276808511	1.548723404
68	0.764546936	0.931890895	0.89618242	0.803589827	0.735019793	0.929098205	0.953429402	0.907848352	0.955037417
69	1	1	1.145851064	1	1	1	1	1	1
70	0.927125506	1.095564339	1.021607378	1.443039087	2.049187527	1.514624506	1	1	1.674042553
71	1.073745023	1.221236586	1.231336589	0.873384498	1.290375096	1.206917173	0.950592054	1.004508024	1.410049889
72	0.941984284	0.859453156	0.641083868	0.399300334	1.189032436	1.200079786	1	1	1
73	0.848806973	0.951680841	0.791216162	0.837388995	1.019343761	0.852171813	1.395205184	1.336846652	1.1613131749
74	1	1	1	1	1	1	1	1	1
75	1.085030066	0.965185044	1.135062953	0.739173979	1.066959176	1.017312095	1.051844185	4.468234851	1.831482875
76	1.180184591	1.002048664	1.402644639	1.103616385	1.604169634	1.821919609	1.183887745	1.184349679	1.257509144
77	1.070558456	0.94876881	1.086730506	0.954924761	2.03255814	1.478043776	1.139059305	1.215713438	1.592123491
78	1	1	1	1	1	1	0.781681497	1.28198834	1.365296103
79	1.465534549	0.976688404	1.352372366	1.012892587	1.209654449	1.285960573	0.950485195	0.853363192	1.541262337
80	0.852931911	1.047319226	1.093470077	1.284239907	2.799558614	1.61547449	0.813207208	0.646440759	0.742621086
81	1.026797538	1.081992557	0.778700258	0.592499284	0.704093902	0.59782422	1	1	1
82	1	1	1	1	2.456382979	1.948723404	1	1	1
83	1.108391862	1.079455253	1.096420233	0.876420233	1.352140078	0.891284047	0.87255175	0.87255175	1.469785575
84	1.00769756	0.930976927	0.950967108	0.755169367	0.839567992	0.909631811	1.219954091	1.328988359	2.135923922
85	1	0.561973169	0.722980727	0.591653805	0.769183585	0.992322609	1	1	1
86	0.764236961	1.015604102	1.064199733	1.236736514	1.892618305	1.253232278	0.716803654	0.666352692	0.943523309
87	0.824757644	1.211308684	1.280035751	1.737087214	2.543371907	1.990638818	0.875189448	0.749969279	1.008315242
88	1.198447502	0.964168451	1.139700214	0.617958601	0.980785153	1.272319772	1.249825565	1.66225928	1.417387664
89	1	1	1	1	1	1	1	1	1
90	0.822997189	1.03375267	1.187230002	1.111417042	1.75005934	1.070021362	1.016506816	1.316930871	1.49975809
91	0.935820983	1.052880688	0.96819119	1.533202796	2.236809004	1.727115941	0.899897843	0.871281954	1.127743989
92	0.860299813	0.913536716	1.1244826	1.117813889	2.230032194	1.86432623	1.072339382	0.700735655	1.069641981
93	1.022850861	1.024844226	1.149312362	1.571990885	2.081177989	1.776848178	0.986691982	0.818235606	1.6886241611
94	1	1	1	1.898723404	1.112872341	1	1.044723142	1.054365831	1.029637956
95	0.872673849	1	1.046382979	1.232659574	1.043723404	1	0.859719597	0.830917874	1.128701953
96	1.018072951	0.777135802	0.898419753	1.523580247	1.971308642	1.573530864	1.107228693	1.335287748	2.086760162
97	0.775925321	1.106164576	1.0579377	0.947741837	0.667436921	0.765966545	1.000090831	0.888072907	0.533469467
98	0.806399367	1.148100616	0.831215777	0.889609001	0.338017625	0.840648528	0.900495219	0.951072974	0.714810464
99	1	1	1	1	1	1	1	1.015531915	1.047553191
100	1	1	1	1	1	1	1	1	1
101	1.139255319	1	1	1	1	1	1	1	1
102	1.162496029	0.915716989	1.050295977	0.799178512	1.449120122	1.2171707	1.485274239	1.095154221	2.136238889
103	0.88384133	0.94960855	1.029638375	1.221759662	2.196905679	1.308189387	1.133491144	1.012089445	1.265333728
104	1.050580851	1.182500839	0.827581385	1.808633516	2.246112541	1.465558228	1.050341742	0.726357334	1.150327595
105	0.930240041	1.133824965	1.015996096	1.126287821	1.219607418	0.915844269	1.201292961	1.267985413	1.450160239
106	1.039715217	1.100472813	1.04964539	1.098108747	1.714766321	1.026004728	1	1	1.465
107	1.163457044	1.22817437	1.481764753	1.395471689	1.184049346	1.111554254	1.072264963	1.23325075	1.44547529
108	1.041855774	1.019343422	0.939101782	1.203563583	2.004271418	1.312911887	0.728415844	0.73236922	0.980462672
109	1.49334328	1.312081208	1.238423842	0.470047005	0.501450145	0.649264926	1	1	1
110	0.877587469	1.273558613	1.285490333	2.52421181	1.743250305	1.295593102	1.202892674	1.275209516	1.178201316
111	0.989168098	1.245199462	1.33280884	1.105579802	1.393797213	1.644293821	1.24600197	1.054703593	1.762178192
112	1.789966774	0.828706571	1.055070666	1.657863618	2.019257841	1.545807759	0.9780087	0.693709867	0.746219706
113	1.035371601	1.000289519	0.883323683	1.6403011	1.959988419	1.83358425	0.834794063	0.834034146	0.996048432
114	1.272159117	0.832568946	0.726371103	0.772130258	0.510539784	0.533619362	1.032859745	1.093603955	0.535248504
115	1.3997825	0.555289221	0.402252076	0.521526655	0.287437055	0.363937046	0.902819395	1.121152275	0.640152547
116	0.696957353	1.109891003	1.037052084	1.202869447	2.309777246	1.493621516	1.4219039	1.114702142	1.404390798
117	0.636209814	1	1	1	2.092340426	1.815638298	0.750057825	0.434842948	0.434842948
118	0.912637363	0.815846306	0.731215693	0.752362098	1.192027355	0.92652749	1	1	1
119	0.972097408	1.017676925	1.039965541	1.158054878	1.438763128	1.230720164	0.950735234	0.754829879	0.719232135
120	0.876362073	1.261593272	1.211190282	2.08071487	1.836993342	1.421416891	1.025498891	1.230413895	1.337891106
121	1	1	1	1	2.117021277	1	1	1	1
122	1.11523043	1.626336249	1.41122449	0.753109815	0.888483965	1.296890185	1	1	1
123	0.856464201	1.25361497	1.100120499	0.628296002	0.401368018	0.716827332	0.821828418	0.863476425	0.601369074
124	1	1	1	1	1	1	1	1	1
125	1.190873313	1.190002863	0.971530249	0.624575613	0.384505256	0.734609564	1	1	1
126	1.177897813	1.458998182	1.282468188	0.474651586	0.871642093	0.812765098	0.953380911	0.651486369	0.752477281
127	1.107848372	0.426077648	0.330286687	0.272976793	0.236581717	0.215310085	1.001437683	1.187918235	0.645964032
128	1	1	1	1	1	1	1	1	1.200425532
129	1	1	1	1.867021277	1	1	0.963806008	0.963806008	0.963806008
130	0.888252735	0.949186028	0.777303619	0.742848111	1.248854117	0.818476371	0.6917355963	0.862683052	1.136360291
131	2.278902452	0.803321904	0.569454081	0.59568897	0.309265271	0.488067684	1.049837995	1.444243631	0.646639517
132	1.259683375	1.073693065	1.000740436	0.766460455	0.558485656	0.58222341	0.996806204	1.275384521	0.91710493
133	1	1	1	1.129361702	1	1	0.862490632	0.594296083	0.566525975
134	1.048358723	1.072739868	0.801220991	1.875389678	0.448259439	0.569579148	1.010625536	1.440659811	1.402527849
135	1	1	1	1	1	1	1	1	1
136	1.031614754	0.963687489	0.943097297	0.446090585	0.584144645	1.264739675	1	1	1
137	0.77359888	1	1	1	1	1.262234043	1	0.762237039	0.485863441	0.562309402
138	0.800565481	1.153033437	1.212030334	0.792433644	0.822905895	0.811892451	1.055970783	1.123577374	1.769492101
139	0.9471507	0.812765807	0.971363765	1.066664304	1.964240147	1.29327332	1.114698906	1.189583493	1.082587293
140	1.147597254	0.941891468	0.844651819	3.119667503	1.371392723	0.998117942	0.80349083	1.270727675	0.997035166
141	1.235957402	1	1	3.404042553	1	1	0.991649433	0.841470119	0.893301222
142	1.146646143	1.038045261	0.795124084	0.772439051	0.444107358	0.708702307	1.120515138	1.198599187	0.746588342
143	0.735853147	1.109368995	1.145748469	0.906489381	0.905823278	1.034278687	1.042040963	1.212450593	1.492993173
144	0.96263682	1.172281993	1.124575311	0.665345413	0.665345413	0.937146093	1.096840659	1.28483124	0.966149922
145	1	1	1	1	1	1	1	1	1
146	0.671883921	1.055585337	1.264916911	1.26330873	2.066718898	1.237907715	0.812355407	0.638088852	0.703956412
147	1	0.566802261	0.49659253	0.752443341	0.609699403	0.49659253	1	1	1
148	1	1	1	3.736595745	1	1	1	1	1
149	1.351067538	0.557174167	0.368658067	0.279770148	0.260961062	0.189006771	0.910505933	1.271688991	0.448703717
150	1.148165514	1.043416502	1.117094862	0.985795455	1.052124506	1.064970356	1	1	1
151	1.101702128	0.936161737	1.055671746	0.961557614	0.936161737	0.936161737	1	1	1
152	1.195741262	1.006998583	1.271881644	2.979270021	1.350815025	1.472802977	0.668511397	0.848091173	0.960512835
153	1	1	1	1	1	1	1	1	1
154	2.030710807	0.714688137	0.506453031	0.374595437	0.187797179	0.187797179	1.11203966	1.242422096	0.348689802
155	0.77471301	1.189890578	1.122010264	1.85077951	2.108840902	1.516219618	0.861500371	0.758752166	0.895865313
156	0.675584216	1.254257827	1.347588517	0.843126887	0.939255734	0.868067949	0.856950597	0.823136881	1.646946672
157	0.911433085	1.046312498	1.120211459	0.52812628	0.522579204	0.856520606	1.000505051	1.39010101	0.949494949
158	0.949952803	0.961900436	0.915338013	0.890617381	0.664845404	0.553465631	0.852271611	1.067313547	0.491072656
159	1	1	1	1	1	1	0.979392625	0.930919406	1.066577674
160	0.826571404	1.175492075	0.956714858	2.678366138	1.552778262	1.242901933	0.87596822	0.847226719	1.014146597
161	0.876625088	1.207121845	1.054714352	1.115590649	0.924013005	0.820560458	0.894463464	1.047928226	0.65785228
162	0.828413883	0.936973103	0.745305321	0.433025559	0.437619876	0.698425443	1	1.276808511	1
163	1.15661003	0.983357362	1.058076851	0.737760923	0.678869178	0.688929982	0.993022174	0.889491911	1.381144363
164	1	1.170120605	1.162646509	1.053677595	1.930609818	1.256072703	1.06893617	1.156489362	1.146489362
165	1.227443038	1	1.186914894	1	1	1.110744681	1.167122833	1.437505184	1.272621714
166	1	1	1	3.348297872	1	1	0.545835251	1.106366565	0.969479901
167	0.816310201	1.329722501	1.142728185	0.761584754	0.737713139	0.794032096	0.87111915	0.722165509	0.502163734
168	1	0.972682119	0.972682119	0.972682119	0.972682119	0.972682119	1	1	1
169	1.020588063	1.078949093	1.095597776	1.147230098	1.213754931	0.919963129	0.980588728	0.923820121	0.445577932
170	1.17498814	1.009916342	1.190069234	0.744555027	0.819666811	1.020878408	1.128216938	1.353100351	1.461454315
171	1.127352682	1.047322073	1.386891872	1.025321207	1.858495741	1.906395265	1.070953534	1.232812156	1.531424796
172	1	1	1	1	1	1	1	1	1
173	1.357964037	0.992164098	0.861015845	1.955285435	0.737464728	1.0459084	1.279049023	1.227014169	1.314277588
174	1.375857454	0.972884386	1.119368296	0.560190703	0.560190703	0.692669845	0.998514806	1.177852038	1.29657477
175	1	0.877684407	0.877684407	0.877684407	0.877684407	0.877684407	1	1	1
176	0.938137755	1.117156016	1.182594512	2.209748609	1.128094416	1.123296872	1.036936387	1.120902889	0.921745882
177	0.769113113	0.961506644	1.069625224	0.972501754	0.688084442	1.002722599	1.057485751	1.180711674	1.375570543
178	1.185903226	1.123265821	1.1868833	1.058127458	1.218413829	1.060835374	1.231792217	1.310157087	1.404498393
179	0.897717505	1	1	1	1	1	1.019656631	0.77963009	0.77963009
180	0.924014548	0.798191145	0.888093952	1.261406587	1.879859611	1.540226782	0.688898488	0.77511879	0.832354212
181	1.095632006	1.117156016	1.216177317	1.892535022	0.901938208	0.901938208	1.573738528	1.244259925	0.729888728
182	1	0.396112726	0.50754947	0.220388258	1.319656757	1.256635093	1	1	1
183	1	1	1	1	1	1	0.612891986	0.540766551	0.732404181
184	1.010760842	0.983129237	1.088032796	0.811583539	0.901298155	1.174804226	1.263908702	1.344190838	1.728483119
185	1.088733457	0.910154366	0.955318379	2.560057887	0.566811384	0.634647853	0.748684775	1.025447177	0.846108881
186	0.978165939	1	1	1.095212766	1.884574468	1.299680851	1	1	1
187	1	1	1.028510638	1.981808511	1	1	1.193278466	1.206419045	1.006501542
188	0.957037451	1.226900319	1.456499122	0.497789193	0.29353339	0.751430522	1.084459247	1.311380632	0.68833658
189	0.654130793	0.962439299	0.694497357	0.398894642	0.367799748	0.527915649	1	1	1
190	1	1	1	1	1	1	1	1	1
191	0.80143711	0.963343109	0.883502611	0.809241113	0.926990201	0.796849295	1.237863209	1.130307671	0.892862115
192	1	1	1	1	1	1	1	1	1
193	0.834550741	0.776124919	0.601774	1.634620715	1.128014414	0.829668299	1	1	1
194	1	0.942406489	0.909418657	0.884632717	3.616584047	1.972780532	1	1	1.30712766
195	0.702598088	1.013515601	1.421995675	0.774482546	1.609051591	1.456518381	0.7808011782	1.017193764	0.700935412
196	1	1.135433202	1.136268694	0.785362186	1.385746512	1.507895396	1	1	1.433617021
197	0.89311261	0.918840859	0.821940888	1.008857225	1.27534418	1.062578223	1	1	1
198	1.080507225	0.998936924	0.886428065	0.860028349	0.878809355	1.195694543	1	1	1.124680851
199	0.73260500	1.125234365	1.13313708	0.856489513	0.901890694	0.956508788	0.99801919802	1.002271404	1.53960396
200	1	1	1	1.163723404	1	1	1	1	1
201	1	1	1	1	1.124361702	1	1	1	1
202	1.602981384	0.892174556	0.69815373	0.89988991	0.265047194	0.450391633	1.034285568	1.38302405	0.34628988
203	0.679492901	0.949551854	1.151947598	1.500657442	2.511369531	2.073006261	0.773748968	0.506079468	0.96198938
204	1.376929815	1.459472196	1.320040057	0.553722903	0.628946748	0.805136664	1	1	1
205	1.056577971	1.020698772	0.91898017	0.520944287	0.813673277	0.57170916	0.964910837	1.018052126	0.412866941
206	1.124255319	0.95588059	1.26927227	0.665387843	1.529372977	1.373516365	1	1	1.080851064
207	1.010221236	1.170120605	1.204178699	1.340920673	0.798369288	0.798369288	0.8546567	1.339243082	0.352328024
208	1.304468085	1.241973841	1.403601155	1.495583489	1.081195855	1.464582979	1.268103034	0.934062827	1.644725309
209	1.052688489	1.154238152	1.19279769	1.147698318	1.044419908	1.023186683	0.825490085	0.858426078	0.994407096
210	0.975843284	1.001454636	1.007190059	0.719504592	0.390673704	0.550268069	1.256771919	2.014665812	0.753325854
211	0.985621219	0.886284062	0.896787943	1.207388238	2.492109403	1.773177044	1.140080093	0.96637744	1.058318038
212	1.263901413	0.926342561	1.004450748	0.756847305	0.898415338	0.968233395	1.261029829	1.363955994	1.275377112
213	0.833457483	1	1.395106383	2.874680851	1.586808511	1.254468085	1.049859104	0.923870557	0.857967458
214	1.453651567	0.933982304	0.815135941	0.731390451	0.456645908	0.569470141	0.939829954	1.30520506	0.6316881794
215	1.390943878	1.102339787	1.378041205	1.888290713	1.752200021	1.009162439	0.95323675	0.841665138	1.139116083
216	1.064770007	0.747079186	0.954601183	1.238497043	1.112072696	0.972739074	1.158106039	1.044907082	0.504449319
217	0.653453711	0.937971118	0.883463849	0.410367452	0.661429758	0.800465624	1.085875417	1.118943861	1.092369478
218	1.829529882	0.971401542	0.826037654	0.673377547	0.425422724	0.669405449	1.078100834	1.444042684	0.797569192
219	1.091290767	1.041766154	0.892441427	0.987141223	0.649498831	0.67376759~	1.028442724	1.039232746	0.738128537
220	0.927886213	1.214646064	1.098391344	0.706666244	0.92705524	1.167020973	1.008191489	1	1.653191489
221	1	1	1	1.587765957	1	1	0.962163782	1.040008991	0.234759372
222	1.003617021	1.102765957	1.041914894	1	1	1	1	1.187021277	1
223	0.970436561	0.947328002	0.836634712	0.657274509	1.307160638	1.62949526	1.090332129	0.99026667	0.997467058
224	1	1	1	1	1	1	1	1	1
225	1	0.915215067	0.324238557	0.324238557	0.324238557	0.324238557	1	1	1
226	1.032953996	1.057207501	0.971135914	0.308965948	0.535675404	0.545056942	1.152582307	0.990148821	0.812833281
227	1.090228844	0.780110132	0.889432383	0.600672198	0.210617132	0.525755098	1.262090424	1.952521799	1.004455883
228	1.06614937	0.920856463	0.915107058	0.858207772	0.547898493	0.7370341	0.958659165	1.219149342	1.067757009
229	1	1.121125337	1.453672507	0.791778976	1.598214286	1.596192722	1	1	1.102765957
230	0.782015943	1.114766759	1.019616929	1.383070745	2.046184739	1.442539388	1	1.125744681	1.872553191
231	1.067234607	1.355688771	1.301875965	1.303279642	0.523734558	0.979169736	1.177523718	0.930142001	1.03812581
232	0.600271657	0.94049135	0.894306923	2.298506072	2.557722769	1.184489238	0.962828685	0.847205522	1.066588398
233	1.854810375	1	1.237340426	1	1.273723404	1.272553191	1	1	1
234	1.082495478	1.005513614	0.802570193	0.568368818	0.44825685	0.788362032	1.075666925	1.141057225	0.892869712
235	1.189731228	1.024649196	0.912182883	0.582589908	0.667224236	0.88825388	1.248596112	1.168552916	1.628941685
236	0.93973822	0.830813295	0.864717245	0.626124026	0.732764937	0.819423167	0.979822355	0.946192946	0.605226678
237	1.088899568	1.001359291	1.113654301	0.962772954	0.842059107	1.049942997	1.062567678	0.952196075	1.08985025
238	1.18750952	0.969870875	1.121347127	1.42950993	1.807218908	1.465151401	0.845035284	0.716159384	0.873904056
239	1.262020721	1.093718777	1.164857124	0.837340971	0.626124026	0.996602944	0.7857792	0.830128322	0.919262787
240	1	0.883161512	0.771773907	0.556938026	1.158371845	1.106647707	1	1	1
241	1	1	1	1	1	1	0.896689879	1.037012306	1.200610512
242	1	1	1	1	1.158829787	1	.003829787	1.39920429	1.018197544	1.402456322
243	0.827739001	0.946950925	0.612262783	0.21520307	0.172745679	0.351867521	1.027419773	1.738084941	0.813078453
244	0.725769453	1	1	2.592553191	1	1	0.856167927	0.700403229	1.069797236
245	1.594680663	1.080780452	1.308123632	0.961068563	1.091037564	1.804932531	1.084111572	1.527985652	0.876059125
246	1	1.034980566	0.996761059	1.445030539	1.971589857	1.457153433	0.972459193	1.020689192	1.07684557
247	1.100172853	1.142689615	1.335819166	1.131376969	1.398716355	1.521105002	1.025552608	0.979126685	1.265488688
248	1	1	1	1	1.740531915	1.326808511	0.721080086	0.721080086	1.124271249
249	1.050204746	1.066043462	1.096734248	1.477285419	2.405414593	1.783707661	1.020776567	1.277836265	1.150606886
250	1.110754102	0.725352789	0.631698186	0.803283095	0.928616684	0.927023135	1.255770547	1.165743794	1.198759825
251	1.346664046	0.936611816	0.83793201	0.866820689	0.554778632	0.549148946	0.926231702	1.129615802	0.74886234
252	1.106321401	1.112438189	1.187980221	0.715100799	0.779307722	1.072499049	1.299580543	0.842004563	0.837809993
253	0.891169266	0.946127567	0.96447321	1.395948067	1.853102965	1.540387436	1.032808536	1.032880903	1.103443077
254	1.011675559	0.972804566	1.142674121	1.706848358	1.302818542	1.350687165	1.262669903	1.031116505	1.256990291
255	0.667343486	1	1	1.296489362	1.776382979	1.200425532	0.732801786	0.525051826	0.766640089
256	0.633708385	0.9131443	0.964366892	1.018011709	1.141304098	1.16227758	1.209514622	1.313139724	1.421222583
257	1.496940354	0.922831588	1.045136241	2.331692436	1.845385842	1.183318311	1.150102722	0.958739942	1.453561034
258	1.446104038	0.743960035	0.698843751	0.899291574	0.202296504	0.382629925	1.213028292	1.318651764	0.3514146
259	1.027720664	1.030213753	0.979188867	0.458847866	0.436500972	0.651194133	0.962612164	0.95789903	0.66418925
260	1.443682335	1.138355699	1.054272125	1.410225922	0.798369288	0.798369288	0.963570128	1.638737098	0.954219794
261	1.043716203	1.123119015	1.215116279	0.642954856	0.937688098	1.01751026 1	1	1
262	1.223942958	0.846782605	0.868461105	0.928652549	1.0352913	1.154337631	0.943020446	1.12131744	1.619199544
263	0.749276338	1.054635108	1.238001315	1.518343195	1.43182117	1.263773833	1.024516161	0.911138268	0.811776736
264	1	1	1.141382979	1.078085106	1.435212766	2.093297872	1.026990553	1.239786529	1.13390995
265	0.991665788	0.962475993	0.933003398	1.484118777	2.121435958	1.195449845	0.853627479	0.994779232	1.130360042
266	1	1	1	1.117978723	2.042978723	1.057234043	0.95100029	0.681356915	0.681356915
267	1.161680401	0.963312154	0.963312154	0.963312154	0.963312154	0.963312154	1	1	1
268	0.554846449	1.041936157	0.836386397	0.666054663	1.203588567	0.779386605	1.015699201	0.6471311125	0.703167775
269	1	0.877684407	0.894771242	0.877684407	1.219047619	0.998412698	1.16216746	1.105656679	1.363791655
270	1	1	1	1	1	1	0.942544871	0.942544871	0.942544871
271	0.799705677	1.103543666	1.150517343	1.241655498	1.693486302	1.320291642	0.918950106	0.659507776	1.021364725
272	1	0.936161737	0.936161737	0.936161737	1.64067324	1.031470969	0.87832818	0.953221968	1.180238895
273	1	1.577220481	1.370323929	3.405015674	1.284952978	0.982236155	0.754782609	0.838015608	1.325529543
274	1	0.951292728	0.932022853	0.910235306	0.910235306	0.910235306	1.135146981	1.350311492	0.679710735
275	1.788300501	0.779022546	0.59312888	0.848924054	0.123670821	0.340559212	1.219077151	1.657638964	0.627698592
276	0.843486809	1.102765957	1.575	2.613085106	1.704893617	1.236489362	1.085402007	1.08383041	1.045719184
277	0.867007222	1.031428955	1.029259127	1.209108805	1.823438618	0.885670186	1.04416511	0.89875998	0.798369288
278	0.648100835	1.164224446	0.839885633	0.905468192	1.342655468	0.872944961	0.906410088	0.955536582	0.904439774
279	0.780706182	1	1	1.072446809	1	1	1	1	1.025212766
280	1.095666974	1.214365119	1.287240613	1.765686759	2.26117836	1.760251976	1.289359581	1.007276352	1.617542985
281	2.0997641	1.983105335	2.530300958	3.218194254	3.086730506	3.73372093	1.335296283	1.600767653	1.177401546
282	1.402008839	1.1285118	1.217290095	0.754535238	0.754535238	1.001123776	1.036352201	1.614779874	1.310314465
283	0.897984491	1.08449425	1.301486597	2.139577128	0.381947134	0.978495773	1.139385843	1.101386075	0.72836569
284	0.654109627	1.020689878	1.133837649	1.370542786	1.926841884	0.998868522	0.952308362	0.744120209	1.225783972
285	1	1	1	1	1	1	0.993919722	0.641217884	0.90779007
286	1.215417517	0.971076339	0.864706812	0.881460408	0.742848111	0.742848111	1.20869943	1.44535097	0.849763445
287	1.24625864	0.886822366	0.84065687	0.596436431	1.047182982	1.022124417	1.35875364	1.053391145	0.52728007
288	1	1	1	1.5392553191	1	1.00610977	1.367305026	1.27370745
289	1	0.919810563	0.881762723	0.890993739	1.882324611	1.369963076	0.769862532	0.621766437	0.962141508
290	1.502584661	1	1	5.887659574	1	1	0.884616237	0.820341763	1.178040293
291	0.792847503	1.122021277	1	1.867021277	1.1588297871	1.184021348	1.016773772	0.889064372
292	0.880299411	0.892853792	0.903434975	1.265718009	1.572061506	1.195162888	0.923096201	0.831055569	1.201473586
293	0.861136091	1.306007841	1.510896055	0.580263483	0.858121711	1.040476106	0.995046093	1.219178082	1.085207203
294	0.883870172	1.200896283	1.294156343	0.73998191	0.867119833	0.891185177	0.948332279	1.061154289	1.184322825
295	1	1	1	1.02712766	1	1	1	1	1
296	0.749362245	1	1	2.137446809	1.181808511	1	1	1	1
297	1	0.73151751	0.73151751	0.73151751	0.73151751	0.73151751	1	1	1
298	0.974832838	1.083510638	1	2.436489362	1	1	1.225801728	0.997949919	1.008273539
299	1	1	1.059893617	3.832765957	1.158829787	1.057234043	0.971768325	1.105070786	1.018126488
300	1	0.42478196	0.42478196	0.42478196	0.42478196	0.42478196	1	1	1
301	1.60447524	1.621627054	0.517712678	7.937691573	0.472338073	0.472338073	0.927142135	1.119997472	0.970427163
302	1	1.076460142	1.160220994	1.010359116	1.255919495	1.416436464	1	1.125744681	1.391595745
303	0.976974088	0.88589555	0.869038862	0.776664215	1.070215766	1.339738875	0.861701374	1.154023233	1.224093356
304	1	1	1	1	1	1	1	1	1
305	1.825939647	0.997632256	1.025247727	0.832722117	0.444067596	0.520908505	0.889901543	1.218541186	0.637514044
306	0.926558293	1.085760561	0.994264928	0.818256644	0.683880732	0.744098983	0.850403317	1.093196645	0.329819713
307	0.891841335	1.267662399	1.209103841	1.930930931	2.605579263	1.468942627	1.163033556	1.227772301	1.168108957
308	0.849525531	1	1	7.322340426	1.170319149	1	0.89881055	1.022776245	1.057231512
309	0.870979279	1.34261713	1.424699056	1.108564995	1.278704425	1.100355071	0.862149894	0.847112723	0.661495004
310	0.932356769	1.19745708	1.109585564	1.006553443	1.324372346	1.229993539	1.07556662	0.968310772	1.420413879
311	1	1.106922851	1.211938985	2.115869757	0.689351716	1.033880903	1.263617021	1.047340426	1
312	1	1.073829787	1.19606383	2.349255319	1.101382979	1	0.554299308	0.610376072	0.577740358
313	1	0.275098197	0.22932982	0.22932982	0.22932982	0.22932982	1	1	1
314	1	1	1	1	1	1	1	1	1
315	1.436797975	1.02479204	0.927418039	1.020714402	0.932392758	1.100717664	1.078406072	1.417077799	1.477419355
316	1.385204082	1.230957429	1.08024792	0.766595988	0.766595988	0.789920078	1.468191489	1.737978723	1.036382979
317	0.451528634	0.787155323	0.820942408	1.10617801	1.010471204	0.960139616	1.29847868	1.298978644	1.264195415
318	1	1	1	1.848085106	1.610319149	1	0.797340945	0.706076767	0.706076767
319	1.150796693	1.217403904	1.319756567	1.610032405	0.496851701	0.640777722	1.244050955	1.593019108	0.760840764
320	0.513400137	1.099541304	0.788592618	0.878166931	0.953916063	0.594547091	1.002166303	1.166762309	0.242669
321	1	0.308549986	0.126905791	0.183590306	0.108982216	0.101068748	1.084809875	0.935695799	0.935695799
322	0.933095096	0.748646066	0.748646066	0.760512902	0.748646066	0.791494106	1	1	1
323	0.961538462	0.839885633	0.839885633	0.967744818	0.839885633	0.839885633	0.985683885	0.909266783	0.909266783
324	0.716011072	1.045011371	1.465470266	1.076760262	1.372430254	1.327306298	1.038080433	1.059479655	1.245318352
325	0.702318006	0.962404779	1.037047186	1.413273415	1.903271771	2.180522826	1.210393027	1.080019734	1.479526394
326	0.657369126	0.890000632	0.784764767	0.91562981	0.415432023	0.649245917	0.961985616	0.983453199	0.508300438
327	0.542318122	1	1	1	1	1	1.157338649	0.468477448	0.468477448
328	1.005589028	1.323831022	1.286681716	2.356788133	1.069719445	1.328152209	1.211938403	0.950785839	0.503458599
329	1	0.951292728	0.910235306	0.929795681	1.117555921	0.910235306	1	1	1
330	0.764896454	1.107748336	0.940524928	1.909431119	3.084566118	1.658369961	1.436152271	1.130385897	1.607075453
331	1	1	1	1	1	1	1.129397669	0.615401372	1.198344407
332	0.991997216	1.076479716	0.936057538	0.476785142	0.378309811	0.650385477	1.106804944	1.11376616	0.430373633
333	1	1	1	1	1	1	0.673262216	0.547487956	0.540605643
334	1.094148936	1.293625914	1.347335423	0.982236155	0.982236155	0.982236155	0.884456154	0.884456154	0.886902522
335	0.841992118	0.98887379	0.936640054	0.887973501	0.998556141	0.979955835	1	1	1
336	1.28716161	1.148311848	1.39907919	1.496009822	0.956414979	0.902516882	1.277102804	1.420093458	1.837476636
337	1.239749577	1.400180397	1.661062029	0.608423146	0.46292613	1.01706832	1.346160298	1.280135539	0.963230114
338	1.290655749	1.124915505	1.11457577	0.754813109	0.610106902	1.005545402	0.994226652	0.931491945	0.720931457
339	1.017719569	0.966750652	0.887069198	0.427247368	0.422928102	0.588005039	0.854372543	0.914302412	0.610243332
340	0.853139498	0.850509599	0.994579365	1.165895269	1.641380296	1.675750698	0.767628102	0.734987254	0.753425014
341	0.897915863	1.006763681	0.963312154	2.008710801	2.539557286	1.43594999	0.80949364	0.689945904	1.166820995
342	0.800829154	0.887750302	0.729766215	0.944059234	0.702624205	1.072058252	1.381478085	1.240418118	1.530166881
343	0.576757884	1.095707599	0.936161737	0.936161737	0.936161737	0.936161737	1.134297681	0.543938571	0.503451485
344	0.950848076	1.200970055	1.346478279	1.425347954	2.29122733	1.822718965	0.885188733	0.621230121	0.95807626
345	1.109281052	0.901648582	1.005451591	0.841536929	0.627326099	1.148359281	0.771106445	1.163646629	1.367644724
346	1	1	1	1.157978723	1	1	1.000383757	0.621790399	0.774455763
347	0.783847058	0.734138057	0.782118161	0.624469247	1.847992236	0.992357152	1.065714792	1.301791415	1.212575381
348	0.871690504	1.20803583	1.368233156	1.974879917	1.695767883	1.119304167	0.941589595	0.728834893	0.974552619
349	0.81952862	1.169768108	1.190724306	1.985113083	1.594732322	1.189636416	0.937530374	0.886562449	1.07077191
350	1.163830439	0.900792514	0.948152392	0.966262453	1.001527738	0.840415035	0.853625105	1.061753036	0.767055429
351	1.452159592	0.743307778	0.867549498	0.5266011	0.359508506	0.686517463	0.999440881	1.662818615	0.56921559
352	1	1	1	1.106595745	1	1	0.707296701	1.011842969	0.822623948
353	1	1	1	1.943297872	1.147340426	1	1.11185	0.84805	0.86045
354	1.068264399	0.898347626	0.821323991	1.368803598	1.436937879	1.30140138	1.076373491	0.829853412	0.445306726
355	0.780587924	1.144569918	0.859303589	0.752853893	0.393581046	0.68845941	1.052631579	1.201913442	0.805315646
356	1	1	1	1	1	1	1	1	1
357	0.757855715	0.900445376	0.763601432	0.879966815	1.140730067	0.77827264	0.860733441	0.816702008	0.753897967
358	1.392420293	1.350475466	1.232940281	2.140129327	1.513883606	1.033320654	1	1	1
359	1.099307637	1	1	1	1	1	1	1	1
360	0.908153117	1.282813679	1.314013913	0.499916185	0.509093957	1.110699019	0.875420875	1.191646192	1.172354172
361	0.813409355	1.221319556	1.201712429	0.812983789	1.190722214	1.377939243	1.100789314	1.032695811	1.1423436551
362	1.070081398	0.828597737	0.947119179	0.541568008	1.232131895	1.233008857	1	1	1
363	1	1	1	1.296489362	1	1	1	1	1.987340426
364	1.084540489	1.294933562	1.1677356	1.503544358	1.791358517	1.322551938	0.853420773	0.880024814	1.332435307
365	1	0.830232817	0.713267238	0.543667149	0.769633508	0.911217556	1.468191489	1.602765957	1.454574468
366	1.212853084	1.269082359	1.337694441	0.441336067	0.483118293	1.09713011	1.340722496	1.091885605	1.338464696
367	1.358742707	1.051496149	1.028610865	0.835917797	0.489400859	1.016341763	1.062207684	0.84448079	1.178818398
368	1	1	1	1	1	1	1.323323479	2.150044085	1.161402417
369	1.166799643	0.94137418	0.983910959	4.27175051	0.713372638	0.838778996	0.722301886	0.812775628	0.865533941
370	1.209814452	0.991910278	0.985263835	2.595615003	0.60965251	0.717990439	1.395051125	1.154569381	0.881961592
371	1.071595745	1	1	1	1	1	1.145595855	0.347890452	0.484122872
372	0.971375426	0.898197199	0.708718328	0.745226069	0.509424664	0.800583138	0.832904162	0.828690482	0.44009551
373	0.908291738	1.11114937	0.979477997	0.942083879	1.235658701	1.163143034	1	1	1.17893617
374	1.252272397	1.069077926	0.998358983	0.441477802	0.272697033	0.644786446	1.285152864	1.274345489	1.068311853
375	1.850711601	0.799503079	0.972669331	0.989377408	1.426614094	1.806416766	0.948859935	0.676547231	0.721009772
376	1	1.089837528	1.111420835	1.793883402	1.93501115	1.261070405	0.808115543	0.995787483	0.908872077
377	0.916495081	0.944628016	0.949467641	1.100697574	1.9155902671	1.337705684	0.966339467	0.737193498	0.87445853
378	1	1	1	1	1	1	1	1	1
379	1.416540671	1.102765957	1.376382979	1	1	1.012659574	1	1	1
380	0.896221173	1.089229792	1.199337358	1.611764172	1.934825035	1.207053057	0.822564663	0.670482113	1.038815048
381	0.636209814	1.929042553	3.302234043	6.955212766	1.681170213	1	1	1	1
382	0.688394031	0.956948292	0.807363804	0.839950754	1.138504155	0.990304709	1.008191489	1	1.508106383
383	1	1	1	1	1	1	0.686673165	0.506510235	0.772838045
384	1	1	1	1.198085106	1	1	0.911148649	1.433004158	0.869984407
385	1.258908698	1.133128531	1.363820049	0.820213599	0.98696961	1.14176735	1.005333792	0.915290204	1.455838495
386	1.034021238	0.892464956	0.872071251	0.454632863	0.767673701	0.745382319	0.728719492	0.628552324	1.425743898
387	0.919223206	1.001594833	1.001914942	0.667314508	0.433022751	0.771064365	1.135632345	1.279908788	1.017042624
388	0.851653483	1	1	2.052765957	1	1	0.933880996	0.786216928	1.142245485
389	0.844941039	0.969870875	1.016914596	0.709808956	0.838858265	0.896851167	1.011521441	1.019609339	1.178238975
390	1.284091547	1.127131938	1.064550582	1.159340476	0.933713828	0.919428591	1.175109346	1.32934206	1.084313056
391	1	1	1	1.661170213	1	1	1	1	1
392	0.835988888	1.04666923	1.17079007	0.949177456	0.916600436	1.130521728	1.02395432	1.028571125	1.007609769
393	1.023439523	1.056842756	0.725980846	0.725980846	0.824606117	0.754556688	0.6118221	0.949142914	0.712467003
394	0.818195266	0.91490272	0.706285016	0.896118977	1.008169502	0.480167057	0.688183737	0.713837886	0.601369074
395	1	1.535531915	1.555851064	1.599893617	1	1	1	1	1
396	1	1	1	1	1	1	1	1	1
397	0.986647626	1.003502962	1.003248201	0.825234062	1.049232533	1.24164066	1.109353508	1.235534159	0.946309033
398	0.993194053	0.876555781	0.905250387	0.644940802	0.596347368	0.767388455	0.671020071	1.174388232	0.676862799
399	0.989700196	1.229515443	1.582518371	1.372921156	2.046190397	1.890546439	0.814625629	0.65972613	0.994776561
400	1.119118523	1	1	1	1	1	1	1	1.17893617
401	1.138726636	1	1	1	1	1	1	1	1
402	1	1	1	1	1	1	1	1	1
403	1	1	1	1	1	1.039361702	1	1	1
404	1.261545413	0.961923848	1.13421128	0.697795591	0.629888348	0.997537933	1	1.20212766	1.30712766
405	1.321638892	0.76947241	0.946005098	0.840744651	0.33895512	0.719133816	1.015603217	1.203538874	0.944530831
406	0.775527654	0.885811294	1.062365976	0.886436741	1.421908506	1.383488206	0.66494772	0.489437371	0.994203002
407	1.10125401	1.068344334	1.238758251	0.385313531	0.478788504	0.762066832	1	1	1
408	1	2.112234043	2.323191489	3.055425532	1.516595745	1	1	1	1
409	0.91112949	1.111936029	1.110659144	0.785217845	0.937758182	0.881069549	0.952445479	0.791489815	0.867141313
410	1	1	1	1	1	1	0.695634077	0.560583312	1.207568393
411	0.680095244	0.778984006	1.138062484	1.064556228	1.254412862	0.90014088	1.165278904	1.147630978	1.236828531
412	0.967318943	0.810306327	0.788834812	0.538219296	0.538219296	0.564214143	1	1	1
413	0.855890814	1.257939472	1.211351755	0.998150717	1.172552367	1.294285003	1	1	1
414	0.910166542	1.0339565G5	1.359023274	1.63801984	1.841949638	2.134586036	0.942946248	0.887360117	1.18651012
415	1.122082766	1.064908722	0.860254083	2.032454361	2.034803032	1.288192591	0.957985224	0.776772768	0.846509701
416	0.900566496	1.09606502	0.982545745	1.045434358	1.503330965	1.202300586	1	1	1.444042553
417	0.992327163	1.024110032	1.078883495	0.898058252	0.820064725	0.933495146	1.012591815	1.158160832	1.903462749
418	0.98046046	0.921979746	0.946560167	0.848785242	0.903199734	0.709432796	1.032142028	1.29890926	1.904618241
419	1.22671022	0.949252113	0.927018844	0.550725293	0.580143703	0.905689367	0.993762554	0.993762554	0.993762554
	U	V	W	X	Y	Z	AA	AB	AC
1	DR.JRF	DR.JRFnCMS	LC.CMS	LC.IMP	LC.IMPnCMS	LC.JRF	LC.JRFnCMS	MG.CMS	MG.IMP
2	1.611129651	1.156933089	0.928919578	1.433143786	1.512059671	1.589203161	1.703020456	1.042762294	1.038673619
3	1.232021277	1	1	1	1	1	1	1	1
4	1.342021277	1.421170213	1.410920595	1.21750798	0.934493376	0.789073755	0.739103415	1.026808511	1
5	1.042978723	1.243510638	0.965282552	0.932283789	1.001 993675	1.005499794	0.717998075	1	1
6	1.372321998	1.765429848	0.936288089	0.906759003	0.852022161	1.087977839	0.939778393	0.871344323	0.916130903
7	1.378297872	1	1	1	1	1	1	1	1
8	1.307197592	1.105090312	0.827537635	0.894885113	0.827537635	0.827537635	1.004225724	0.857719418	0.754092769
9	2.14092585	3.001736993	1.236828394	1.089150874	1.270221089	1.304873591	1.023718612	0.990974006	0.92388771
10	0.815831495	0.957264228	0.870267347	0.940529542	1.030726833	1.099495184	1.808195539	1.124058627	0.871162503
11	1.584361702	1.537553191	1.229574468	1	1.464361702	1.351914894	1.341489362	0.938704225	0.781521127
12	1.253262813	1.25276816	1.863879575	1.351287722	1.659984305	1.477491617	2.075408433	0.986408256	0.883513718
13	0.998088998	0.855400855	1	1	1	1	1	1	1
14	1	1	1	1	1	1	1	0.80129047	0.91943128
15	2.113429664	1.655843604	1.154433323	1.978970782	2.296683854	2.702102922	2.668385401	0.88520216	0.720711954
16	1	1	1	1	1	1	1	1	1
17	1	1	1	1	1	1	1	1	1
18	2.120359367	1.521937539	0.774219681	0.750917322	0.732856802	0.716511794	0.915034548	1.126663586	0.850600739
19	1.119017886	0.992487109	1.104549758	0.913738974	0.821248816	0.692804106	0.97931928	1.196504562	0.94600479
20	1	1	1.185009336	0.57113897	0.67607362	0.802133902	0.501467058	1	1
21	1.97763864	2.017531306	0.883091149	1.273147592	1.374564669	1.993154798	1.795784796	0.962793418	0.972991531
22	1	1	0.534945144	0.77021536	0.632629013	0.705526209	0.617106867	0.872813368	1.366414902
23	1.279747183	1.542639919	1	1	1	1	1	1.055759121	1.046120758
24	1.224330357	0.892485119	0.466310311	0.552445257	0.594223285	0.749613166	0.652318657	0.920070679	0.744413263
25	2.283471074	3.206198347	1	1.253404255	1	1	1.06606383	0.968927355	0.977617764
26	0.866758875	0.904564315	1	1	1	1.233617021	1.050851064	1.210088404	1.138429537
27	1.286849526	1.543194053	0.883209621	1.257540167	1.742553791	2.083623039	1.81574744	1.021905762	0.940119062
28	1	1	1	1	1	1	1	1	1
29	1.025466143	0.754048086	1.601727147	1.373797485	2.177726073	2.428296568	2.257461184	0.882703383	0.962997286
30	1	1	2.772124469	2.532634134	3.809395857	4.503857155	4.162953974	1	1
31	0.529070749	0.529070749	1.282828283	1.227144325	1.30671118	1.415254237	1.509972607	0.929256339	0.722885148
32	1	1	1.156779152	0.824906929	1.090068452	1.195268404	0.980785397	1	1
33	0.464979314	0.62404478	0.856679614	0.931557836	1.009714008	0.755246481	0.562665219	1.094315041	1.997275957
34	0.8406037	0.718787963	1.001684042	0.836701417	0.942502005	0.699906442	1.023509757	1.211821725	0.83589065
35	1.232098537	0.835969624	0.912567364	1.447596465	1.757016598	1.728950205	2.065186463	1.00325032	0.771899393
36	0.949494949	0.949494949	1	1	1	1	1	0.894378651	1.002920529
37	0.608917398	0.563436563	0.595804019	0.609875135	0.670342904	0.616720543	0.790898431	0.946547782	0.795976223
38	1.231274539	1.500679553	0.500201045	0.651655274	0.733246214	0.675981772	0.647533843	0.888424522	0.738381857
39	1.278085106	1	1	1	1	1	1	1	1
40	0.53972894	0.615997874	1.350202545	1.386717636	1.190506076	0.74861642	1.017801107	1.153621068	0.885241405
41	2.152956094	1.77746077	0.745854162	1.298659049	1.199079584	0.864000635	1.355946997	0.886341129	0.716081359
42	1.430358476	1.572115385	0.569617515	0.907255971	0.934795777	0.798221703	0.910263067	0.789662265	0.66654502
43	1.074961405	1.084966682	0.55864057	0.708086785	0.702260658	0.752935822	0.718585951	0.98219956	0.878525901
44	1.465497037	1.356379951	1.380028055	1.598741328	1.503279372	1.316525761	1.422451378	0.928481807	0.753615532
45	1	1	0.930600931	1.765468765	1.46955747	1.850806851	2.082566083	1	1
46	2.283784687	2.959946506	0.756478352	1.012795751	0.804764204	0.899163045	0.907130211	0.843546089	1.154068852
47	1	1.320106383	1	1	1	1	1	0.912354135	1.058219178
48	0.531043444	0.628382577	1.36704157	0.985466317	0.918726981	1.058943996	0.759979521	1	1.046808511
49	0.419417391	0.534772511	0.617922839	0.436102741	0.27783982	0.292937061	0.396521208	1.22504075	1.351212306
50	0.793095718	1.033325861	1.180851064	1.639255319	1.63606383	2.131914894	2.186170213	0.949168392	1.055974885
51	1.098097079	1.295105322	0.583356471	0.604260045	0.668002063	0.601800801	0.667883037	0.916693864	0.836569843
52	1	1	0.451640801	0.970739442	1.177917648	1.116369577	0.904819103	1	1
53	0.553450259	0.366885023	3.54637032	1.360416549	0.740186351	1.211808509	1.22792992	1.234755417	1.567946045
54	1.432446809	1.148723404	1	1	1	1	1	1	1
55	1.460350173	1.265138618	0.712224067	1.077163508	1.637819887	2.030889822	2.205435632	0.979894018	0.973177487
56	1.477340426	1.43787234	1	1.04287234	1.017340426	1	1	1.245265503	0.872632752
57	1.614341247	1.670414646	0.899364924	1.315974597	1.246116268	1.307718613	1.312652662	1.128036015	0.97430387
58	1.7171089151	.776710706	0.988396636	1.007054574	1.283988938	1.922027202	1.668480163	0.787709938	0.777748574
59	1.69731947	1.21406086	1.268063584	1.489956647	1.932153179	1.726445087	2.051372832	1	1
60	1.240213362	1.946388211	0.947580645	0.947580645	0.947580645	0.947580645	0.947580645	1.142158338	1.222757375
61	1.160330579	1.298347107	0.647796045	0.746771503	0.963831308	0.826495116	0.748248749	0.789441914	0.810678812
62	1	1	1.12563	1.319722992	1.947146814	1.475844875	2.344487535	1	1
63	1.011841846	1.20771097	1.404916619	0.914558493	1.640632557	1.584821147	1.628898282	1.104914617	1.114362407
64	1.019390376	1.010250963	0.508779856	1.163825526	1.211681239	1.458139989	1.269892053	1.161122904	0.864404188
65	1.167540936	1.379394291	0.630957175	0.951738488	0.822862129	1.309101893	1.155457108	1.110648494	0.956544509
66	0.602417457	0.728756517	1.254577995	1.025847777	1.2860211	0.860870384	1.034118312	1.04833124	1.154675235
67	2.723510638	2.034148936	1.180851064	1.329255319	2.219787234	2.611808511	2.302340426	1.095943236	0.952182631
68	1.262230194	1.177871235	0.497450765	1.100803092	0.997067546	0.969542471	0.812889466	1.07197757	1.02605501
69	1	1	0.496881277	0.754202347	0.734749974	0.72259224	0.617295697	1	1
70	1.575425532	1.62	1	1	1	1	1	0.847556122	0.748288489
71	1.049708481	1.185550279	1.328915744	0.670949983	0.498046324	0.474843907	0.365505203	1	1
72	1	1	1	1	1	1	1	0.815684949	0.794388574
73	1.356760259	1.156025918	1.296123599	0.844804788	0.654186095	0.654186095	0.654186095	1.030224435	0.817131791
74	1	1	1.703444391	1.084178336	1.162079511	0.756478352	0.771849348	1	1
75	2.20031991	2.405626647	0.96165356	1.199248382	1.317767416	1.708608811	2.048924769	0.996082699	0.762948857
76	1.575906613	1.524088496	0.890982584	0.7496882	0.999924867	1.091481465	0.670934199	0.831016278	0.952419733
77	1.537370539	1.597928623	1	1	1	1	1	0.914837223	0.95303947
78	1.957809144	1.93840135	1	1	1	1	1	1	1
79	1.820021564	1.504188438	1.227530078	0.940299262	1.11257709	1.147811141	1.026488727	0.981981335	0.751830581
80	0.73804107	0.499550979	0.636327024	0.886494832	0.951201504	0.871526379	0.985568533	0.868985849	0.897287736
81	1	1	1.173013608	0.552842406	0.515803336	0.765144864	0.515803336	1	1
82	1.241276596	1.157340426	1	1	1	1	1	1	1
83	1.834029518	1.865868375	1	1	1	1	1	1.082630945	0.707405178
84	1.69970487	2.292097065	0.767379176	0.783238262	0.724942017	0.591299442	0.680749702	1.217244554	0.984657871
85	1	1	0.453024332	0.479170576	0.293988866	0.478763996	0.293988866	0.946036904	0.866194731
86	0.958671501	0.592572999	1.013239287	0.944159879	1.610882526	1.480952781	1.997200996	0.927551583	1.044476389
87	1.006635809	0.891123582	0.99263376	1.152486812	1.411567445	0.895685757	0.829559156	0.831346969	0.891501584
88	1.826611778	1.820401898	0.404818059	0.641004043	0.668463612	0.871226415	0.761623989	1.031948593	0.896596977
89	1	1	1.105901563	0.692725516	0.733413309	0.555366723	0.5147789	1	1
90	1.625949853	1.253066568	1.121393901	1.031229966	0.855160729	0.556552798	1.013142229	0.911511355	0.818444672
91	1.731089043	1.479687352	1.056676273	1.193497632	1.269849945	1.370250754	1.60469045	0.949679338	0.882079895
92	1.111623345	0.829671408	1.25393617	1	1.420957447	1.816276596	1.425	1.023030104	1.065964797
93	1.897227128	1.77455846	1.184923072	1.198903748	0.949402439	1.193144958	0.931518968	0.983965903	1.134486627
94	0.881034075	0.799574065	1	1	1	1	1	1.294787234	1
95	1.413463558	1.207834489	0.693984525	0.840502538	1.259963391	1.0104002	0.91039188	0.8433033	0.989184842
96	2.95755751	2.621054856	1.186911575	1.103101348	1.033228724	1.573149345	1.628161344	1.030046108	0.861105819
97	0.382084802	0.462816562	0.722820247	0.842597737	1.063114405	1.209901393	1.067529149	1.203566852	1.309272418
98	0.641895811	0.477254138	1.083803886	1.032127419	0.888917014	0.430828693	0.507554811	0.874254758	0.86299014
99	1.637553191	1.286170213	1.131808511	1.196170213	1.478723404	1.974574468	1.963829787	1.045696371	0.893026791
100	1	1	1.739965096	1.555376561	1.728755538	1.805544368	2.132635253	1	1
101	1	1	0.638500204	0.721097677	0.638500204	0.638500204	0.638500204	1	1
102	2.369311432	2.217302257	1.495113077	1.149104659	1.295141614	2.158165085	2.175215809	1.011974181	0.871464654
103	1.35355286	1.200828507	1	1	1	1.307765957	1.17	1.089723368	0.967908275
104	0.937735085	0.855936462	1.248323618	1.108248812	0.890015837	0.965191899	0.965242444	0.997082821	0.736820781
105	1.270029838	1.106531108	1.974352083	0.951698983	0.960376272	0.477289307	0.598003456	1.106402722	0.970770182
106	1.831595745	1.479574468	1.033810376	1.205008945	0.996690519	0.84078712	0.883542039	0.922787376	0.907248335
107	1.333922285	1.052040683	1.115858587	0.944515691	0.670052375	0.689938249	0.558380572	1.179071469	1.226367997
108	0.799168516	0.804091106	1	1	1	1	1	0.794425986	0.855682075
109	1	1.11393617	0.983675178	0.983675178	1.326182503	1.109564671	0.983675178	0.88612368	0.88612368
110	1.206452194	1.449400739	0.836294516	0.902960311	1.001633005	0.963917122	0.796318554	0.871224897	1.040165568
111	2.339048832	2.453352175	1.080214356	1.199357947	1.557072102	1.052760025	1.173599685	0.840948461	0.722667997
112	0.378650832	0.324518401	1	1	1	1	1	1.454978038	1.508756617
113	0.805106642	0.728253711	1.476328079	1.002656159	0.63502627	0.305283129	0.556859311	0.828264006	0.953744891
114	0.412230029	0.447650273	1.418761259	0.862304079	0.720938063	0.750826333	0.644051247	1.118098608	1.379272291
115	0.640152547	0.640152547	1.588451792	0.970335063	0.667772817	0.556614778	0.552190177	1.193320022	1.204029769
116	1.320476264	1.501204146	1.378149389	1.104858556	0.960121405	1.096116437	1.359657346	1.093302316	1.005697964
117	0.434842948	0.434842948	1.217395015	1.119665415	1.163280983	0.941532946	0.962103107	1	1
118	1	1	1	1	1	1	1	1	1
119	0.693666202	1.026692335	0.49564269	0.555458132	0.65225992	0.577565467	0.624512142	0.922121241	0.954443559
120	1.472345405	1.226071693	0.895900125	0.949750041	0.994199315	0.767008097	0.926615226	0.853587371	0.904278715
121	1	1	1	1	1	1	1	1	1
122	1.119680851	1.157340426	1	1	1	1	1	0.908104323	0.822685104
123	0.601369074	0.601369074	0.605175139	0.878523909	0.743411622	0.790642114	0.732862866	1	1.197765957
124	1	1	1.820957447	1.196170213	1	1	1	1	1
125	1	1.096382979	0.948575567	0.756478352	0.781345566	1.623531305	0.982858522	1	1
126	0.820198182	0.942804333	0.715699711	0.715699711	0.943962235	0.718212273	0.74120603	0.807369371	0.983554229
127	0.607094312	0.680024049	1.441950976	1.080838377	0.604353751	0.445069299	0.514077089	1.061354489	1.25245389
128	1.396382979	1.052446809	1.196170213	1.245106383	1.278191489	1.817978723	0.947479912	0.788093499
129	0.963806008	0.963806008	1	1	1	1.003510638	1	1	1
130	1.236588417	1.379203768	1	1	1	1	1	0.951117917	1.039816233
131	0.586528343	0.738943551	1.130290134	0.810065617	0.756762924	0.876115477	0.755930195	1.123079597	1.418534932
132	0.871188133	0.762537529	1.119334065	0.988280278	0.888218075	0.796084888	0.738569338	1.040234239	1.045128397
133	0.370794052	0.400023668	1.008510638	1	1.200425532	1	1	1	1.063723404
134	1.50235647	2.087189374	0.214881701	0.473311236	0.792341982	0.614904561	0.686341296	1.095309576	1.056322099
135	1.157446809	1	1.854477412	2.269099171	3.119553595	3.369326383	4.406789628	1.460618146	1.413160518
136	1	1.226382979	1	1.338829787	1.406489362	1.439680851	1.09606383	0.835271558	0.858097241
137	0.580555125	0.489843387	0.965290614	0.965290614	0.965290614	0.965290614	0.965290614	0.969272015	1.193235719
138	2.087226091	2.457363683	0.515803336	0.883834504	0.78500878	0.996268657	0.819743196	0.998329828	0.89533589
139	1.671742291	1.205830591	1.769357411	1.242167001	1.066934198	1.383906982	1.742707208	0.886316324	0.971287129
140	0.415125535	0.521245649	0.422180759	0.414201632	0.29149601	0.266284397	0.455068111	1.311887823	1.506495515
141	0.508703961	0.456820502	2.247943284	1.155135156	2.1235167	0.698563142	0.4427342	1	1
142	0.874423859	1.050655219	0.810258757	1.374240785	0.999167984	1.221066644	1.108037274	1.063616121	1.008906702
143	1.650107797	1.893550126	0.602525479	0.823729248	0.8298827	0.955002884	0.825139414	0.940375736	0.896274479
144	1.204081633	1.524430926	1	1.100531915	2.055744681	2.017553191	1.77787234	0.95710898	0.992576554
145	1	1	0.863680789	0.750520546	0.544341988	0.480771682	0.461479624	1	1
146	0.57766974	0.721005868	1.080999188	1.109063035	0.911750383	0.949373253	0.891460005	0.932191032	1.209705513
147	1	1	2.052066815	1.360978962	0.994079712	0.852309969	0.499312824	1	1
148	1	1	1	1	1	1	1	1	1
149	0.459187449	0.54771948	0.782238564	0.774487396	1.01318361	1.022441949	0.764202193	1.267950324	1.444896681
150	1	1	0.728254848	0.588144044	0.54598338	0.71933518	0.547257618	1	1
151	1	1	1	1	1	1	1	1.007446809	1
152	0.735484476	0.82589188	0.916485841	0.921232505	0.562493219	0.694314853	0.645546273	1.04601725	1.22587519
153	1	1	1	1.224787234	1.847659574	1.541489362	1.670425532	1	1
154	0.33286119	0.33286119	0.860537096	0.675921711	0.67935063	0.968472159	0.829555454	1.832821745	1.48836692
155	0.872938846	0.818767022	0.747930186	0.738811815	0.785186843	0.640803312	0.660774222	0.909454293	1.335331943
156	1.562608647	1.597207424	0.609360819	0.609360819	0.609360819	0.895047323	0.748282121	0.909980172	0.836351619
157	0.99030303	1.293535354	0.570422963	0.998482918	0.981795012	1.21609321	0.937435524	0.847729984	0.984001123
158	0.362416767	0.369625425	1.218879436	1.058427788	1.005890523	0.843764726	0.736954042	1.22902423	1.814486369
159	0.78424829	0.914483564	1.36195584	1.195526901	1.058138871	1.265247903	1.330689793	0.973948945	1.053846601
160	0.973226072	1.327887226	1.096179734	0.989532563	1.47734763	0.906883907	0.990669823	0.944122305	0.885279865
161	0.618817141	0.590091685	0.697972338	1.062757102	0.853480387	1.081835261	1.331130762	1.123546073	0.908836858
162	1	1.157340426	1	1	1	1.425106383	1	0.942900798	0.919472582
163	1.631364036	1.851088024	0.562022224	0.746355111	0.653164158	0.592481677	0.65852313	0.983174731	0.877379042
164	1.204148936	1.148723404	1	1	1	1	1	1	1
165	1.912996599	1.604628017	1	1.253404255	1.805638298	2.778617021	2.328085106	0.930108303	1.012490975
166	0.812607368	0.939595097	1	1	1	1	1	1.099661175	1.669996495
167	0.532200794	0.581689266	0.461077623	0.429089161	0.453348619	0.671424873	0.627306682	0.869839259	1.046277029
168	1	1	3.273465067	1.616737238	1.144024935	1.154904728	0.863502705	1	1
169	0.390472833	0.421572732	1.184377709	0.876133697	0.712521934	0.569390711	0.524285956	1.100338219	2.201754816
170	1.73331798	1.961022511	1.406904358	1.262900653	1.306014303	1.242835829	1.038431857	1.174746855	0.984657871
171	1.891037216	1.852851795	1.095762637	1.115690977	1.224926712	1.749637263	1.641052974	0.897061304	1.036978306
172	1	1	0.988002181	1.942192329	3.726504272	2.656153427	2.84548264	1	1
173	0.930305616	1.180240976	0.520525452	0.573092797	0.888008698	0.92710691	1.068521724	1.552102416	0.991185155
174	1.482873851	1.449271326	0.626404656	0.801878638	0.81663113	0.740275457	0.875583473	0.833777228	0.702606297
175	1	1	2.162234043	1.36712766	1.215425532	1	1.035638298	1	1
176	1.055071821	1.434529422	1	1	1	1	1	0.779672968	0.739112917
177	1.415241729	1.794082249	0.419926014	0.860410003	0.602269662	0.57047898	0.587453277	0.94100039	0.876434779
178	1.719832203	2.015173152	0.735483302	1.111133139	1.119129439	1.274121068	1.06632743	0.824712815	0.940955895
179	0.77963009	0.77963009	1	1	1	1	1	1	1
180	0.800561555	0.494470842	0.84078712	0.957602862	1.231216458	0.84078712	1.174776386	1	1
181	0.696977847	0.995293643	0.987179487	0.838703182	0.859846959	1.136931132	0.93381662	1.177926704	1.87767916
182	1	1	1	1	1	1	1	0.676440102	0.918185838
183	0.575391986	0.643031359	1	1	1	1	1	1	1
184	2.109684578	2.406007291	1.565092565	1.104346104	1.089199089	1.175626176	1.209088209	0.997502498	0.949959132
185	0.667705857	0.644363041	1.258993202	0.859121808	0.62340621	0.715542899	0.45252618	1.507952345	1.323669229
186	1	1	1	1	1	1	1	1	1
187	1.142346448	0.982086386	1.049162615	0.840163618	1.217874508	1.670448406	1.328548275	0.976899827	1.117659758
188	0.686954063	0.876139006	0.63211454	0.882400683	0.789648929	0.608141011	1.063325911	0.958494852	0.791308298
189	1	1	1	1	1	1.081914894	1	1	1
190	1	1	0.556658079	1.306499816	2.059919028	1.636555024	1.383496503	1	1
191	0.733517631	0.606769953	0.990935067	1.052714553	1.009064933	1.092521431	1.154941374	1.157773944	0.915577889
192	1	1	2.296382979	1.167553191	1	1.097340426	1.020319149	1	1
193	1	1	1	1	1	1	1	1	1
194	1.477340426	1.131276596	1	1	1	1	1	1	1
195	0.663385301	0.7365256121	1	1	1.931276596	1.497978723	1.697340426	1.117401906	1.129771669
196	2.214255319	1.832234043	1.257325241	1.2047928	1.789870239	2.097111762	2.137714525	0.903664112	0.970442398
197	1	1	1	1	1	1	1	1	1
198	1.138617021	1	1.267663719	1.365944549	1.036768359	0.533936202	0.67196661	1	1
199	1.523005242	1.904251602	0.62401015	0.693266833	0.754079713	0.900205626	0.753117207	0.947282213	1.003397234
200	1	1	1.081228831	0.863509418	0.628439004	0.558559629	0.603838612	1	1
201	1	1	2.08610977	0.919362627	0.756478352	0.756478352	0.756478352	1	1.130957447
202	0.195544262	0.175626909	1.500708737	1.081344144	0.675738504	1.069701952	1.225283967	1.238422634	1.674594122
203	0.949813712	1.002119448	1.014027234	1.010242107	0.852942555	0.744779338	0.669803361	0.773818859	0.801955339
204	1	1	0.767409584	0.767409584	0.989550167	1.205241244	0.841129888	0.986151909	0.986151909
205	0.341399177	0.336076818	0.980243232	1.1368063	1.307953963	1.15423326	1.163459298	0.799787975	1.14011308
206	1.278085106	1.191914894	1.024542152	1.441981167	1.863794765	2.16675317	1.940016312	0.949314079	0.979783394
207	0.236429103	0.414726103	0.680675422	1.073889931	1.059933292	1.276057953	1.088805503	1.102478464	0.943526872
208	1.973789125	1.653631917	1.675467207	1.360146333	2.794032087	2.900652327	2.315100494	0.832501387	0.947981434
209	1.014518954	0.895147167	0.683064298	1.214627108	1.992785643	1.369780864	1.638470556	0.914200554	1.225179192
210	0.753325854	0.753325854	1	1	1	1	1	1.172264616	1.028600613
211	1.12339396	1.199315869	1	1	1	1	1	0.889892367	1.199678337
212	1.312521266	1.509186798	0.557173245	0.919309856	0.71434649	0.633230915	0.724225951	1.088323554	0.786088592
213	0.960685392	1.134896828	0.653917373	0.711332115	0.712067887	0.657167033	0.598293009	0.873035603	0.957915298
214	0.632981863	0.641667597	0.956840931	1.011044931	0.972814161	0.782691901	0.732300772	1.19964347	1.693517274
215	0.933174399	0.797909408	0.877598152	0.957138976	0.747316941	0.638500204	0.651473985	0.92553917	1.196658426
216	0.62675386	0.788253797	0.877346809	0.977732366	0.915036693	0.978608172	0.799037619	1.191302572	1.211132095
217	1.265402034	1.458600359	0.905880211	0.982644578	1.021967352	1.49778506	1.27653377	1	1
218	0.868403025	0.772731446	0.924675837	0.889693684	0.740201633	0.735240091	0.655812892	1.144349119	1.339430195
219	0.373219281	0.41047616	1.439359787	0.950733899	0.81592424	0.919176952	0.699682886	1.313626731	1.28709192
220	2.049893617	2.378085106	0.84078712	0.84078712	0.84078712	1.515026834	0.84078712	0.869263923	0.951494591
221	0.234759372	0.265577783	1.339801051	1.22425394	1.647904325	1.794322119	1.301732424	0.904570736	1.125580228
222	1	1	0.930600931	1.13978814	1.089199089	1.326205326	1.129294129	1.107135492	0.998247061
223	1.204684521	1.291259925	1.228749355	1.540518028	1.970251081	2.722779739	2.171988418	1.16250575	1.07656923
224	1	1	1	1	1	1	1	1	1
225	1	1	1	1	1	1	1	1	1
226	0.789568335	0.956907492	0.856285912	0.95530243	1.062479991	0.844344842	0.829353913	0.87124332	0.777659853
227	1.250528176	1.381554181	0.487956811	0.790801495	0.784468439	1.012406561	1.136004983	1.360228855	0.667381837
228	0.961520122	1.005102041	0.738350768	0.945184078	1.170764842	1.067518	1.203233256	0.958322468	0.879182964
229	1.185531915	1.061276596	1	1.291382979	1.847659574	2.160531915	2.417533191	0.952240408	0.840711922
230	1.866595745	1.832234043	1	1	1	1	1	0.923570319	0.728445075
231	0.791844157	0.863255498	0.821112684	0.378419422	0.535512734	0.915231861	1.017682831	1.018825055	0.95631404
232	1.024228595	1.003474754	1.276380814	1.096899225	0.990213178	1.288299419	1.262936047	1.169955525	0.927388012
233	1	1	1	1	1	1	1	0.884189508	0.950535487
234	0.899978884	1.077285845	1.253127744	1.126975417	1.331595698	1.5470259	1.545050483	0.938209954	0.60928497
235	1.900561555	1.922332613	0.957902973	1.219405321	1.532316119	2.043740219	2.102503912	1.022700038	0.799842504
236	0.607947836	0.550187401	0.852128126	0.81671159	1.039052216	0.718046762	0.944399173	1.067294423	0.837324458
237	0.920080289	0.772073	0.834029906	1.128138448	1.5338844	1.281477354	1.899817343	0.936843723	0.758157046
238	0.847601397	0.804690284	0.93067768	1.032684963	0.753752554	0.758193445	0.825295319	1.002511688	1.038495971
239	0.961976081	1.089934203	0.870610633	1.024608659	1.119235651	0.902482019	1.005076858	0.691436777	0.82793472
240	1	1	1	1	1	1	1	1	1
241	1.970046742	1.274348946	1	1	1	1.642978723	2.06893617	1.230242622	1.319274972
242	1.781871649	1.186265352	0.902636917	0.978814514	0.982946435	1.272481406	1.141461949	1.28873842	1.15740913
243	0.813078453	0.813078453	1.045567215	0.896430637	0.668388003	0.576055523	0.622407668	1	1.097340426
244	1.176008278	0.934998809	0.896438953	1.110125969	1.218507752	1.229360465	2.027252907	0.90438173	0.872632752
245	0.926216835	0.727936174	1.446170213	1.376595745	1.03287234	1.248510638	1.035638298	0.964633464	1.004141018
246	1.10096057	0.907906227	1	1	1	1	1.004893617	1.084680851	1
247	1.787719151	2.056549098	1.038625963	1.284487825	1.594555492	1.129612233	1.385124307	1.004798038	0.856250479
248	1.333384474	1.114682418	1.033297872	1.243829787	1.889574468	1.468829787	1.548404255	0.852924188	0.79032491
249	1.558861779	1.334097102	0.814464609	1.138884653	1.063121685	1.098435938	1.139071052	1.02845267	0.899574447
250	1.975155022	1.594454468	1.271580504	1.298454788	0.995183136	1.66060187	1.324709081	0.963759768	1.212740123
251	0.803195311	0.729476324	1.088252716	0.777517782	0.843217788	0.690082584	0.548784249	1.136889061	1.599732078
252	0.871366546	1.017661344	1.460820551	0.989281094	1.271946036	2.098133432	1.602199224	0.907248335	1.236174114
253	1.146200112	1.091389895	1.153640996	1.077855273	1.490564808	1.542270964	2.08862671	1.001475331	0.826265468
254	1.94684466	1.85973301	1.152952134	1.384992306	1.021037499	1.77533004	1.887341055	0.805760897	1.114750616
255	0.89118163	0.882155956	1	1.071808511	1.185425532	1.173510638	1.299255319	0.799244903	1.101283665
256	1.667059301	1.403432169	0.497034721	0.572927161	0.581755487	0.580727246	0.617484239	0.97975823	0.776012396
257	1.463897449	1.732901044	1.717886892	1.144454187	1.18643139	1.291977203	1.357737834	1.17912892	0.996062718
258	0.223332169	0.312579213	1.358159756	0.921119684	0.57429218	1.062701566	0.842239367	1.071370618	1.589720367
259	0.754010695	0.700625397	0.646565227	0.915585142	0.770026852	0.909543522	0.864175431	0.990314608	0.627880569
260	0.490012143	0.612537948	1.137029741	0.970739442	0.853408927	0.728967472	0.790851871	0.950043215	1.407490637
261	1	1	0.340460584	0.515545585	0.400469698	0.371656911	0.370955869	1	1
262	2.889815091	2.631486057	0.935771194	1.32141876	1.514893217	2.24528261	1.826841047	0.938081662	0.894495819
263	0.785265363	0.591081405	1.029144212	0.921233024	1.205733994	1.131666307	1.430135805	1.022490086	1.246921311
264	1.370690713	1.595816464	1.705106383	1.215319149	1.259893617	1.381276596	1.534787234	1.05628228	1.082154752
265	1.041224971	1.004806927	0.687687688	0.865700752	0.789696913	0.73972942	1.005293954	0.932566269	0.870084474
266	0.681356915	0.681356915	1	1	1	1	1	1	1.080531915
267	1	1	0.834580509	0.839070341	1.042609385	1.395457347	0.931684127	1	1
268	0.738085927	0.811833063	1	1	1	1	1	1	1.378723404
269	1.874264912	1.156230748	0.658060763	1.029576267	1.063492774	1.777126493	1.694706698	1.102332127	1.149348038
270	0.942544871	0.942544871	1.84393617	1	1	1	1	1	1
271	1.036003996	0.080946558	0.577963793	0.725960877	0.805100834	0.825467026	0.807755798	0.786921695	0.83901315
272	1.384526103	0.902818249	0.399616049	0.823612978	0.859589173	1.072528316	1.125897485	0.904483793	0.993681807
273	1.679063545	1.610345596	0.711770632	1.165172009	0.658920874	0.82926225	0.941766173	0.900181984	0.840650591
274	0.656669693	0.603324672	0.541104912	0.993275553	1.283926634	1.771291315	1.536561068	1.025125628	0.816766761
275	0.267973826	0.36703655	1.608805619	0.988357228	0.665562413	1.289777179	1.401792465	1.290240811	1.273034409
276	1.039539951	1.295567382	0.791784239	0.95864058	0.959763037	0.893101567	0.782523969	0.887794433	1.065024982
277	0.798369288	0.798369288	1.088357702	1.052992831	0.898699148	0.829080688	0.763624082	1.056153101	1.428149225
278	0.928608958	0.892814922	0.527003795	0.835155211	0.81134646	0.710694476	0.802815531	1	1.197765957
279	1.119680851	1.387553191	1	1	1	1	1	0.927141614	1.317543205
280	2.253426364	2.580363818	1.56980809	1.500820432	1.99522009	3.269387173	2.241706499	0.884051204	1.141978911
281	0.983016983	0.681634155	1	1	1	1	1	1.209195978	0.927208945
282	1.840125786	1.711383648	1	1.433191489	2.055744681	1.686276596	1.548404255	0.873075453	0.802592708
283	0.583487434	0.654502398	0.57013144	0.690176711	0.516269259	0.958175785	0.68393909	0.975506815	1.101109095
284	1.097865854	1.175391986	0.735524257	0.767057903	0.736697966	0.795774648	0.828090767	0.989006302	0.997820215
285	0.452363537	0.905184237	1	1	1	1	1	1	1.280531915
286	0.898667568	1.028483151	0.766758001	1.022795966	1.499392673	1.862969973	1.531877631	1.031686047	0.801356589
287	0.442389849	0.530723288	1.617511057	1.361044096	1.731905911	1.868884868	1.529386141	0.864257882	0.95940037
288	0.786Q55347	1.228320583	1	1	1	1	1	1.112351492	1.29498893
289	1.054987044	1.060564803	1.490766823	1.684976526	2.26486698	1.951799687	2.047339593	0.892422305	1.031244788
290	0.738425054	0.834504311	2.378682105	1.181309949	1.888415915	0.759662864	0.576252909	1	1
291	0.751661039	0.78286679	0.646225767	0.772996013	0.646225767	0.646225767	0.646225767	1.115762798	1.061632032
292	1.833996057	2.334948374	0.814410677	0.973541347	0.693155379	0.821787357	0.680963117	0.808554122	0.935129297
293	1.038166624	1.149651073	0.71748591	0.955232931	1.132410644	1.361810658	1.212456303	0.917858487	0.845878811
294	1.030693428	0.947937456	0.777345491	1.261049589	1.719225795	1.657106839	2.051979526	0.786103971	0.738023298
295	1	1	1.564574468	1	1	1	1.184574468	1	1.50787234
296	1	1	0.659745257	0.775640175	0.831564283	1.07861218	1.257463182	1	1.297021277
297	1	1	1.705106383	1	1	1	1	1	1.836595745
298	0.847927954	1.773539318	1	1	1	1	1	1.261653201	1.150670337
299	0.594965599	0.89122453	1.288324302	1.290100974	1.235794024	0.74638003	0.857984661	0.929071794	0.965068005
300		1	1	0.419221373	0.796122626	0.689534242	0.624596107	0.588659469	1	1
301	0.850134805	1.159111972	1.416666667	1.185324869	1.563106796	0.849103809	0.684889221	1.054783444	0.723909638
302	1.980319149	2.290319149	1	2.705106383	2.739893617	1.931489362	2.199148936	0.772203412	0.821037896
303	2.266663125	1.817803513	0.874272847	1.074341653	0.828642022	1.086069932	1.08137862	0.931518345	0.881553425
304	1	1	1	1	1	1.097340426	1.227978723	1	1
305	0.774141092	0.657752351	0.868643303	0.880948632	0.793397984	0.673720595	0.584791167	1.220011355	1.112243685
306	0.315068933	0.391104541	0.506165527	0.581336492	0.506165527	0.506165527	0.584782726	0.9943101	1.497403983
307	1.082411363	0.887172746	1.112366533	1.15558443	1.48985933	1.409185922	1.444890119	1.175604679	1.164502379
308	0.78333477	0.673633856	0.947111728	0.888988322	0.712022909	0.623920533	0.593494116	1	1.411276596
309	0.629003471	0.655452029	0.515366793	0.653000476	0.640357203	0.509321345	0.582971476	0.87410894	0.83583529
310	1.453295991	1.960790415	0.999150434	0.796043449	0.760665089	1.313429213	1.08252928	0.913580247	1.01449515
311	1	1	1.313496388	0.64156274	0.596440247	1.254247891	0.587056544	1	1
312	0.482185337	0.474594392	0.746039948	0.971633733	0.849402206	0.728346667	0.824367906	0.863247296	0.871408666
313	1	1	1.399354578	1.159453697	0.824410765	0.594421714	0.560998098	1	1
314	1	1	1	1	1	1	1	1	1
315	0.792106262	0.713472486	1.324242844	0.582160926	0.926640793	0.416349019	0.58347718	1.158498162	1.200857693
316	1	1	1	1	1	1	1	1	1
317	0.882651239	0.671380616	1	1	1	1	1	1	1.181170213
318	0.706076767	0.706076767	1	1	1	1	1	1	1
319	0.604165605	0.646178344	0.880580921	0.646527614	0.64133841	0.671327964	0.752266065	0.940996992	1.12875761
320	0.189530013	0.163060943	1.006789806	1.023034838	0.795407996	0.920196399	1.167566051	1.268970098	2.011456777
321	0.935695799	0.935695799	0.899729891	0.911949088	0.589362309	0.272574755	0.360989168	1.406355004	2.327027027
322	1	1	1.846919302	1.238367866	0.878044348	0.475236278	0.487186478	1	1
323	0.909266783	0.909266783	2.316515945	1.43944442	0.774176799	0.525896759	0.629786682	0.986151909	1.246537977
324	1.683611505	1.617004836	1.520592021	1.76137221	2.165424045	2.13753162	2.252585097	1.030649335	1.052181901
325	1.44206545	1.32468344	1.185825498	1.084369629	1.144474775	1.320341725	1.239156809	0.994642947	1.261232122
326	0.520250906	0.508300438	1.573032344	1.040475757	1.069846471	1.036045877	0.700467261	0.969422992	1.065800213
327	0.468477448	0.468477448	1	1	1	1	1	0.963454888	1.45779629
328	0.484884222	0.605266142	1.350114109	1.299704658	1.536582092	2.262384213	1.653309169	1.108662004	1.491515707
329	1	1	2.125213383	1.232843974	0.878200751	0.905001707	0.802321611	1	1
330	1.4264948	1.475966751	1.080462957	1.080116432	0.930903042	0.7546261	0.799916834	0.903714535	0.855155466
331	0.511926805	0.87964274	0.868600998	0.868600998	0.868600998	0.868600998	0.868600998	1	1
332	0.423156698	0.623909646	0.670614254	0.670614254	0.670614254	0.670614254	0.704715702	0.96129269	1.209251842
333	0.539114476	0.539114476	0.715699711	0.760164459	0.805238313	0.715699711	0.715699711	1	1.164468085
334	1.031990967	1.130033873	0.467057538	0.873298221	0.985789526	1.154476796	0.780184836	0.859546452	1.086503292
335	1	1	0.854390111	1.095255408	1.151881476	1.527176877	1.711688784	1	1.130957447
336	1.975420561	4.114859813	0.709495612	0.821359777	0.73403724	0.945922808	0.823500036	0.887794433	1.000927909
337	1.102425605	1.107122488	1.178784388	1.229367123	2.002303835	2.239192302	1.841814609	0.975056958	0.921531497
338	1.048432948	1.584898045	0.688343487	1.054886758	1.233611216	1.969918675	1.554172618	0.741739026	0.827655332
339	0.81340984	1.25119541	0.814769871	0.814769871	1.550836439	1.597122302	1.470312906	0.664783937	0.803976943
340	0.633331062	0.624669323	1.305114654	1.002119357	1.171058496	1.239159898	2.242061507	0.815678188	0.857057137
341	1.209220722	1.293337882	1	1	1	1	1	0.903752964	0.999793793
342	1.725508894	2.224170182	1.057862546	1.105585064	0.851118622	1.655882826	1.171334299	0.910475447	1.133798692
343	0.489218956	0.44078182	0.938520939	0.930600931	0.930600931	0.930600931	0.930600931	0.690719377	1.557351753
344	0.920521173	0.738532286	1.025565784	0.989950557	1.285886562	0.981629618	0.966274068	0.941332547	0.932134434
345	1.801206839	1.781075216	0.820273322	1.305840958	1.479963364	2.115540522	1.671941454	0.717002407	0.734058666
346	0.327937483	0.542038794	0.749633403	0.95060585	0.725476576	1.097244733	0.725476576	1	1.247553191
347	1.216566158	0.877350124	1.156382979	1.17712766	1.094574468	1	1.155319149	1.147409105	0.983191767
348	1.320326894	1.191758332	0.815347894	0.971716229	0.80586314	1.009556541	1.181251234	0.972111947	1.015435828
349	1.521504941	1.422606512	1.018662191	1.152794806	0.910749101	1.496824312	1.46798183	0.973177442	0.999541495
350	0.725814597	0.645352892	1.181685544	1.405068151	1.763409484	1.8	1.71906316	1.011935875	1.190111815
351	0.522677191	0.794211478	0.930600931	0.97950698	0.930600931	2.261063261	2.058608059	0.921703808	1.040106416
352	0.635373784	0.62209892	0.69340556	0.845470174	0.319666548	0.304907717	0.347789419	1	1
353	0.83605	0.75365	1	1	1	1	1	1.19	1
354	0.359324957	0.40166913	1.242113827	1.013719907	1.088458267	1.104470988	0.993676269	1.059146833	1.047019968
355	0.618289832	1.086248032	0.506617503	0.622875562	0.61078824	0.44334831	0.546127173	0.865266994	1.132655548
356	1	1	1.867021277	1.13893617	1	1	1	1	1
357	0.71142572	0.632468504	0.785095797	0.740482146	0.714753017	0.528711619	0.561532752	1.100013962	1.276725462
358	1.278085106	1.669255319	0.487956811	0.983232973	0.650695598	0.865137043	0.735568937	1	1
359	1	1	1	1	1.094574468	1.859574468	1.299255319	1	1
360	1.248339248	1.357630358	0.767379176	0.866670846	0.905158904	1.095718674	0.757224347	0.934937475	0.916684502
361	1.889101396	1.720431087	0.828889719	1.051306945	1.333980583	1.445170525	1.186880757	0.9731415	0.935971495
362	1	1	1	1	1	1	1	0.784940283	0.803369453
363	3.235425532	2.640425532	1	1	1	1	1	1	1
364	1.620046083	1.14751861	0.52660431	0.816151026	0.558844691	0.57100764	0.71244047	1.013540254	0.738888765
365	1.530957447	1.65287234	0.955645161	1.205745968	1.277520161	1.748387097	1.570060484	1.075	1.181170213
366	1.654282978	1.611247947	0.507054598	1.04488221	0.732470392	1.170657147	0.92819274	1	1
367	1.54474764	2.114286534	1	1	1	1	1	0.904574578	0.806360588
368	1.425081687	2.076915098	1	1	1	1	1	1	1
369	0.874624604	1.016612105	1.281010444	1.643669291	1.927149251	1.215774039	1.406492772	0.992527534	0.764896138
370	0.582719279	0.754433394	1.13425386	0.848810607	1.044696416	1.314406643	1.234552952	1.18336969	1.258520353
371	0.356069578	0.356920799	0.65172556	0.944452083	1.001993675	0.646225767	0.929740135	1.251101675	1.278343081
372	0.44009551	0.44009551	1.33202235	1.179613757	1.012666811	0.5471954	0.60662363	0.985749572	1.260307809
373	1.26893617	1.235	0.388333471	0.538254978	0.706601669	0.67731141	0.752375444	0.735278434	0.725375181
374	1.160723574	1.689475813	0.561686919	0.954777222	1.066857279	1.929473433	1.82749583	1.107846801	0.525875759
375	0.806290717	0.406168567	2.234498475	1.313816297	1.412577645	1.342044327	1.322600801	0.951581983	1.243091017
376	1.003094911	0.821870702	1.353154164	1.051608955	0.865571931	1.035697894	1.054209802	1.057813444	1.300371042
377	0.811071812	0.68139729	1.048555785	0.957968591	1.160289827	1.042195338	1.233959542	1.021617489	1.102874222
378	1	1	1	1	1	1	1	1	1
379	1	1	1	1	1	1	1	1	1
380	1.018143301	0.91440872	0.714153636	0.852313382	0.761144833	0.587932629	0.595369217	0.984542947	0.955531247
381	1.708297872	2.234468085	0.502406761	0.535384898	0.450413375	0.392761345	0.172698879	1	1
382	1.342021277	1	1	1	1	1	1	1.043621943	0.836351619
383	0.970129508	0.681451051	1.372391936	1.271590809	2.505238137	2.149837134	3.240602166	0.877707995	0.892950392
384	0.360888773	0.459459459	0.694944756	0.659527774	0.371071086	0.344836285	0.399298724	1	1
385	1.526726313	2.005849966	0.718467988	1.022027997	0.626518866	0.712410289	0764780075	0.889165668	0.836444472
386	1.568973587	1.829488465	0.440755849	0.446898298	0.683406011	0.576405495	0.572654382	0.901565747	1.060663402
387	1.391678653	1.565592001	0.977197267	1.138591001	1.232129909	0.864423921	0.909227951	1.034619901	0.796563121
388	1.198756492	1.372837432	1.139182211	1.234683909	1.420198167	2.348234637	3.199516212	0.88612368	0.88612368
389	0.761941096	0.71722875	0.821721036	0.630957175	0.700295342	0.630957175	0.634044838	1.042676128	0.952863659
390	1.277848435	1.153674349	1.255764179	1.154416772	1.035947077	1.276948147	0.98217239	1.036976822	0.917667167
391	1	1	1.709526136	0.962432829	0.592134831	1.044357596	0.459208598	1	1
392	0.860349604	1.301790471	0.664880549	0.902737209	0.855459909	0.544781894	0.633823387	0.914661765	0.90344307
393	0.698198951	0.734420423	0.45538223	0.70400155	1.041711075	1.490359461	1.601346769	0.981990521	1.206635071
394	0.601369074	0.601369074	1.581543265	1.071268813	0.93523135	0.850682634	0.713084199	1.130848694	2.234082776
395	1	1	1	1	1.362765957	1.845106383	2.042765957	1	1
396	1	1	1	1	1	1	1	1	1
397	0.987666208	0.817606602	0.942013669	0.961671246	0.931515536	1.581131544	1.490734869	0.895127694	1.016120268
398	0.646136926	0.697071762	0.908102518	0.847005701	0.640356188	0.959815347	0.618359316	1.230757659	1.00742115
399	1.219066996	0.843888432	0.97140624	1.33852233	1.510823075	1.187172974	1.549186912	0.830499064	0.725422056
400	1.954148936	1.815957447	0.666051979	0.913156227	0.947617127	0.724370426	1.020803319	0.937188435	0.937188435
401	1	1	1.358990944	1.504435409	2.033727592	1.275827019	1.474311588	1	1
402	1	1	1	1	1	1	1	1	1
403	1	1	1	1	1	1	1	1	1
404	1.849148936	1.767234043	0.9303044	1.103714587	1.141011151	1.279347498	1.346820374	1.021234799	0.879326473
405	0.690563003	0.755576408	0.7744892	1.190134267	1.311675423	1.345300642	1.438937536	1.211726861	1.167495248
406	0.993776229	0.856177538	1	1.081382979	1.805638298	1.292978723	1.493723404	1.038132807	0.750558843
407	1	1	0.839550496	0.813922942	0.985113835	0.773759486	0.628166959	1	1
408	1	1	1.135531379	1.702733183	2.557648932	3.180443147	2.278227411	1	1
409	0.936504134	1.013912492	0.719315219	0.904104673	0.861031463	0.737053937	0.698955448	0.878072761	0.656750474
410	1.136636391	1.462651068	0.91419624	1.101920011	1.807387888	1.307955967	1.246269298	1	1
411	1.350526859	1.294156658	1.057361983	1.097673829	0.957850035	1.868606199	1.866070863	1.137602086	1.164985245
412	1	1	1	1	1	1	1	1	1
413	1.00393617	1	1	1	1	1	1	1	1
414	1.596098575	1.44306855	0.882254389	1.135471116	1.693874816	1.566479024	1.409864629	0.904023739	0.933341246
415	0.715770213	0.667921011	1.437536384	1.272790779	0.949528467	0.867330306	1.174991268	1.3219676	1.059596295
416	2.041276596	1.864680851	1.187664338	1.190443994	0.941702351	0.933889265	0.927503568	0.966855069	0.807480287
417	2.185061528	2.103787084	1	1	1	1	1	1.044953747	0.601392787
418	2.517463449	2.999187747	0.644690782	1.238817581	1.125891352	1.56599248	1.426422922	0.95957385	0.854510531
419	1.103287874	1.184480389	0.979133065	1.042842742	1.630947581	1.680040323	1.582862903	0.911687259	0.864762676
	AD	AE	AF	AG	AH	AI	AJ	AK	AL
1	MG.IMPnCMS	MG.JRF	MG.JRFnCMS	PA.CMS	PA.IMP	PA.IMPnCMS	PA.JRF	PA.JRFnCMS	max
2	1.042724783	1.061480176	0.934393638	2.061728395	2.220716652	1.612165011	1.918598816	1.485596708	2.220716652
3	1	1	1	2.774439063	2.988138776	1.408520312	0.975882179	2.397746368	2.988138776
4	1	1.121808511	1.052021277	1.266808511	1.183617021	1.006595745	1.366276596	1.421914894	1.751382979
5	1	1	1	1.104787234	1.082659574	1.242021277	1.145531915	1.248085106	1.500295975
6	0.966428192	0.863150771	0.873471262	1.240099212	1.1604023	1.21717681	1.268282046	1.123906348	1.765429848
7	1	1	1	1.210001574	1.324867503	0.501757884	0.493257071	0.785433174	1.795
8	0.673885857	0.800875398	0.831798545	1.017539221	1.153181738	1.060197426	1.053851578	0.972677596	2.296542996
9	0.933641128	0.841495821	0.998708451	1.086904413	0.831903202	1.169639556	1.136323648	1.370006758	3.001736993
10	1.167537815	1.009579075	1.438226698	0.818387935	1.001350181	1.381846436	1.1150456	1.334004178	1.808195539
11	0.770591549	0.786760563	0.939267606	1.549893617	1.153404255	1.301170213	1.449680851	1.201914894	1.843345703
12	1.135766423	0.806443494	0.891970803	1.21049036	0.98618491	1.1734477	1.211325338	1.066039168	2.075408433
13	1	1	1	1	1	1	1	1	2.517521713
14	1.032547251	0.935533604	1.089076686	1	1.143297872	1.075957447	1	1.34	1.955319149
15	0.723129081	0.778566047	0.853748117	0.947388342	1.044158466	1.15640508	0.969341408	1.036882833	2.702102922
16	1	1	1	1	1	1	1	1	1.888025331
17	1	1	1	1.228191489	1	1	1	1	1.843919659
18	0.986876155	0.99103512	0.928650647	0.956442556	0.993777508	0.901148379	0.807305104	0.861739262	2.120359367
19	1.469944382	1.112740732	1.056884983	1.127041831	1.110166785	1.19478765	1.079388863	0.95792292	2.387178962
20	1	1	1	1	1	1	1	1	1.185009336
21	0.790824241	1.004247094	0.929503319	1.464515247	1.050458088	1.182606318	1.149842746	1.01422125	2.017531306
22	0.82620436	1.346925997	1.129573827	0.669932691	0.93550311	0.678509557	0.971542984	0.855130499	1.729840999
23	0.903297754	1.09160427	0.837661303	1.394516191	1.049778335	1.334329221	1.356929453	1.329124904	1.654850234
24	0.695457853	0.916224925	0.900010394	0.822128702	0.851054762	0.956903899	0.705092691	0.801832517	1.669270198
25	0.79604143	1.1928916	1.051787741	1.294877092	0.952558011	1.164428837	1.235144254	1.265819734	3.206198347
26	1.166926677	1.374310972	1.366614665	1	1	1.113404255	1	1.015531915	1.994787234
27	0.950819034	1.062215478	1.145363994	1.311621461	1.118511186	1.224747575	1.125678084	1.248584439	2.083623039
28	1	1	1	1.104787234	1.072553191	1	1.00787234	1	1.781395534
29	0.927252267	0.922453167	0.948169723	0.823264104	0.801658604	0.929400211	0.804604808	0.810097116	2.428296568
30	1	1	1	1	1	1	1	1	4.503857155
31	1.227146814	1.079160452	1.066375453	0.971569005	1.07845027	0.939909406	0.907382421	1.100086739	1.509972607
32	1	1	1	1	1	1	1	1	1.195268404
33	1.514607185	1.346624556	1.062179234	0.646814692	0.75982569	0.53529778	1.074891056	0.959037145	1.997275957
34	0.866779457	1.017862128	0.84455649	0.757427743	0.928413731	0.904359244	0.859886582	0.767961501	2.520246578
35	0.719737331	0.866807087	1.044149837	0.924415464	0.925495794	1.102052628	0.917817733	0.850065591	2.065186463
36	1.364932212	1.044531376	1.598628155	1.202901317	1.665012407	1.021950754	0.916714386	2.177642044	2.177642044
37	0.937174211	1.120667581	0.940329218	0.595014251	0.787850428	0.625515804	0.893350917	0.800740205	1.338085106
38	0.570032669	1.010948583	0.855843659	0.866031294	1.174891307	1.129399916	1.187467761	1.292230601	1.715795832
39	1	1	1	1	1	1	1	1	1.98
40	0.859546452	1.01892831	1.163222385	1.09192667	1.161290323	0.909130971	1.114577825	1.297109113	1.679574468
41	0.716081359	0.813133237	0.716081359	1.051601988	1.138257375	1.404991012	1.00058158	1.008036375	2.152956094
42	0.612832592	0.88544224	0.863346825	0.902549722	0.97826087	1.073803191	1.095137604	1.065188483	1.572115385
43	0.68911809	0.905898714	0.920825125	0.900278229	0.973823325	1.094551356	0.754300951	0.856178994	2.063944927
44	0.709172555	0.866968236	0.866538995	0.892290483	0.89231992	1.050866916	0.871213682	0.863089105	1.958297872
45	1	1	1	1	1	1	1	1	2.082566083
46	0.747873697	1.052621316	0.961554039	1.280618973	0.939772301	1.051601273	1.080541541	0.93297279	2.959946506
47	1.260273973	1.100329782	0.838597159	1.592978723	1.183617021	1.327978723	1.820531915	1.358297872	1.820531915
48	2.033297872	1.048723404	1.02393617	1.570623703	1.30236236	0.929129188	1.682020362	1.454680241	2.033297872
49	0.986552567	0.984413203	1.325539935	1.571228606	1.718012343	1.146083858	1.252274607	2.41025641	2.93712766
50	1.302117427	1.088972013	0.971945762	1.036868268	0.916045291	0.808386265	1 .048099052	0.962625426	2.186170213
51	0.502692559	1.090323107	0.936398499	0.865859103	1.106788893	1.096907646	0.939224382	1.184440013	1.533123028
52	1	1	1	1	1	1	1	1	1.177917648
53	1.015685107	1.372211054	1.134018316	1.610238028	1.636434176	0.978022338	0.831555594	2.078402658	3.54637032
54	1	1	1	1	1	1	1	1	1.91976154
55	0.832413808	1.03626491	0.979981246	0.838172428	0.886653982	1.126467172	0.959697546	1.21982258	2.205435632
56	0.888135908	0.943093205	0.9506127	1	1	1.065319149	1	1	1.897178466
57	0.817033181	0.90423699	0.876910536	1.147759623	0.875239393	1.17717697	0.895201781	0.79459618	2.376071691
58	0.73686493	0.6006124	0.912410965	0.987289139	0.733456644	0.989064812	1.171663214	1.219754365	1.922027202
59	1	1	1	1	1	1	1	1	2.118660204
60	0.892158338	1.1410295	1.119807345	0.912001571	1.063445296	1.205526092	1.220454397	1.468670202	1.946388211
61	0.667727597	0.932283378	0.901607858	0.971050455	1.200419927	1.193612012	1.07660495	1.228478717	1.548198417
62	1	1	1	1	1	1	1	1	2.344487535
63	1.166210465	1.119942783	1.082451834	0.859078647	0.761527288	0.983731065	0.917244242	0.867337622	1.640632557
64	0.835638987	1.086601425	0.977729006	0.870923559	0.878318223	1.015009457	1.130813005	1.027312158	1.495203492
65	1.303154091	1.102452309	0.943818165	1.175614195	1.110267219	0.90969527	1.290969527	1.309390726	1.509356575
66	1.432184275	1.14683286	1.044986085	1.141747967	0.978857146	1.030791714	0.923486229	0.755454992	1.990445474
67	0.776800864	0.977093938	1.141215487	1	1.001382979	1.06	1	1.285	2.723510638
68	0.788877073	1.122202349	1.070068159	1.021036755	1.068164378	1.126220529	1.098806594	1.029821915	1.306231353
69	1	1	1	1	1	1	1	1	1.145851064
70	0.748288489	0.798439739	0.748288489	1.164525994	0.958205912	1.324057085	1.006422018	0.958205912	2.049187527
71	1	1	1	0.873358713	1.227488152	1.036593893	1.066350711	0.850672053	1.439610062
72	0.794388574	0.902053579	0.902138088	1.400319149	1.052234043	1.156276596	1.240425532	1.118297872	1.400319149
73	0.725836013	0.776913234	0.825154753	0.904878576	0.80024501	1.020429488	0.715968869	0.765078908	1.613131749
74	1	1	1	1	1	1	1	1	2.645851064
75	0.670402612	0.886996736	0.89390642	1.140970133	0.871578484	1.14918911	1.028693036	1.049167095	2.405626647
76	1.123702944	0.833277443	0.968880245	1.146331069	1.121773871	1.181861766	1.031428952	1.055400186	1.821919609
77	0.894958225	0.960357246	1.066954768	0.994198781	0.950985615	1.078079678	1.069614633	0.900846504	2.03255814
78	1	1	1	1	1	1	1	1	1.957809144
79	0.83977028	0.827494616	0.870782484	1.07212766	1.082659574	1.172340426	1.219361702	1.062340426	1.913829787
80	0.857724057	0.944575472	1.040035377	0.75	1.089388283	0.841901206	0.787406663	0.873420448	2.799558614
81	1	1	1	1	1	1	1	1	1.288229337
82	1	1	1	1	1	1	1	1	2.456382979
83	0.707405178	1.013320289	1.088801927	1.350898324	1.432500251	1.561678209	1.35792432	1.35862692	1.865868375
84	0.951263169	1.16231973	1.099314718	1.540947162	1.396029366	1.591665805	1.427825458	1.229603971	2.292097065
85	0.850266914	0.695021469	0.845740977	1.767919698	1.282807868	1.379682026	1.674885476	1.534997305	2.20384652
86	0.869662023	0.914722063	0.856348127	1.039223205	1.159170877	1.252007398	1.10206153	0.987955612	1.997200996
87	0.943522843	0.811617544	0.849224244	0.900411076	0.979135965	0.987163577	0.843403397	0.817265183	2.543371907
88	0.982939633	0.968775455	1.197619694	1.283341154	0.990239324	1.16015955	1.098967621	1.19042703	1.826611778
89	1	1	1	1.124361702	1	1	1.018510638	1	1.124361702
90	0.979971086	0.958918137	0.918830191	1.034680315	1.13261019	1.148155221	1.113245741	0.935604614	1.75005934
91	0.760484261	0.834468516	0.838494548	1.142975682	1.059636772	1.360443796	1.013490545	0.962847469	2.236809004
92	1.243132094	0.916515874	1.080769863	1	1	1	1	1	2.230032194
93	1.065417066	0.898421692	1.041765492	1.261537121	0.919325937	1.191407548	1.019694667	0.92233787	2.081177989
94	1	1.085319149	1.344361702	1.095371042	1.096878664	1.380479089	1.415321905	0.882237981	1.898723404
95	0.753975678	0.988347857	0.964715343	1.022453648	1.229743559	1.151366482	1.04550927	1.258036359	1.873970081
96	0.892771406	0.872670807	0.88913234	1.070765512	0.870168942	1.186093754	1.018797089	0.967960092	2.95755751
97	1.248675535	1.209789623	1.298972579	1	0.884422364	1	0.986143877	0.902838752	1.309272418
98	1.208123137	1.1231 94222	1.004442788	0.644906687	1.057503888	1.053479782	0.877741058	0.700835925	1.269471638
99	0.893026791	0.895591868	1.030590918	1	1	1	1	1	1.974574468
100	1	1	1	1	1	1	1	1	2.132635253
101	1	1	1	1	1	1	1	1	2.534574468
102	0.917178584	0.826623842	0.827528142	1.364487174	0.998893946	1.233589994	1.236142426	0.984685413	2.369311432
103	1.016804174	0.952074739	0.977008008	1.256778797	1.153312946	1.354943935	1.218858308	1.195922528	2.196905679
104	0.865546389	0.893391272	0.795301113	0.92116702	0.820162504	1.056500169	0.927257088	0.685190305	2.246112541
105	1.05015981	0.925250026	0.901020724	1.13492823	0.919279482	1.064396285	0.957894737	0.903349282	1.974352083
106	0.907248335	0.918154618	0.928964386	1	1	1	1	1	1.831595745
107	1.042344906	0.836124888	0.985080088	1.018801171	0.826134305	0.969885399	1.051646795	0.921804732	1.48176753
108	0.677042676	0.910519016	0.86548821	1.104715721	1.197273175	1.412608054	1.1l476562	1.294469042	2.004271418
109	0.88612368	0.904977376	0.907334087	1.075754752	1.278978755	1.092620201	1.132500932	1.085165859	1.608816121
110	1.201211099	0.860723593	0.936302315	0.815528634	0.785242291	0.682406388	0.647026432	0.735613987	2.52421181
111	0.685770313	0.82996577	0.868256212	1.271474506	1.422028524	1.432313432	1.008918068	1.16489463	2.453352175
112	1.601531704	1.113695236	1.16015317	1.564978541	1.786437768	1.481716738	0.604806867	1.100257511	2.019257841
113	0.782279394	0.874969945	0.759858139	1.402247913	1.41554271	1.386191394	1.074438022	0.998779705	2.027340426
114	1.682495375	1.155668798	0.979307994	0.993958814	0.782782619	0.78501745	0.925617895	0.79997755	1.682495375
115	1.484479942	1.244781267	1.253040479	1.10419914	1.400689623	0.935383307	1.075575079	1.085824949	1.588451792
116	1.101459091	0.934245204	0.968123795	1.337530769	0.958964727	1.179507975	1.164340291	0.939058921	2.309777246
117	1	1	1	0.542412002	0.542412002	0.542412002	0.542412002	0.542412002	2.092340426
118	1	1	1	1	1	1	1	1	1.92027355
119	0.96205318	0.924612767	0.935598439	0.826833369	1.453581349	0.932974557	1.054991856	1.229217949	1.480646388
120	0.820685901	0.863473054	0.826891671	1.009434548	1.057848675	1.095959282	1.015113897	0.949165167	2.08071487
121	1	1	1	1	1	1	1	1	2.117021277
122	0.822685104	0.952914406	0.896201645	1	1	1.177659574	1	1.043617021	2.137556404
123	1.053617021	1.007446809	1	0.898018167	0.949793559	0.864244426	0.938315442	0.904128819	1.402035969
124	1	1	1	1	1	1	1	1	1.820957447
125	1.210638298	1	1	1	1	1	1	1	1.623531305
126	0.844355007	0.790992991	0.929151343	1.077208918	1.370437655	0.984971098	1.125268373	1.138728324	2.016582507
127	1.542896025	1.433274459	1.214349828	1.160124906	0.945314044	0.708407447	0.91450255	0.918158821	1.542896025
128	0.723447772	0.894594595	0.929218408	1	1	1	1	1	1.817978723
129	1	1	1	1	1	1	1	1	1.867021277
130	0.677427259	1.018499234	0.916508423	0.881824464	1.088919604	0.954695539	1.046379482	1.117254089	1.857056954
131	2.146350365	1.38408064	1.070481404	1.206647618	1.31580634	0.594502452	1.761743264	1.508345128	2.278902452
132	1.175083201	1.014988892	1.047273315	0.932202346	0.897365385	0.840058024	1.331219966	1.2057565	1.455321987
133	1.210638298	1	1	0.802463639	0.991392104	0.836449985	0.799050163	0.721430692	1.210638298
134	0.753079312	1.217022064	1.036232033	1.184661819	1.297571683	1.44022957	1.974299172	2.255270499	2.255270499
135	1.492821535	1.03000997	1.133000997	0.957290673	0.850957658	0.930872532	0.826594261	0.892712996	4.406789628
136	0.703946554	0.988432513	0.812817023	1.301004923	1.16672287	1.083293991	1.244351521	1.209415256	1.439680851
137	1.123530625	0.969272015	1.082800577	0.757148611	0.757148611	0.757148611	0.757148611	0.775996778	1.262234043
138	0.855128047	0.973339107	0.915316096	0.814132175	0.734735879	0.878435856	0.791401784	0.831237137	2.457363683
139	1.036709825	0.950444275	0.941685707	1.270879685	1.155314051	1.244865651	1.096226254	0.993753209	1.964240147
140	1.181462006	1.107536859	1.506495515	1.216565526	1.208366146	0.822856349	0.994487423	1.836151387	3.119667503
141	1	1	1	0.721799892	0.825232281	0.927512862	1.151117254	0.834062812	3.404042553
142	1.128301047	1.055177021	0.950233801	1.307042323	1.110166785	0.879270959	1.130259635	0.936380831	1.374240785
143	0.801783156	0.988377647	0.979063843	1.023038811	0.926507019	1.101734104	1.011808423	1.138728324	1.893550126
144	1.043767399	1.026394474	0.991390865	0.996678406	0.844485353	0.832119417	0.944573395	0.95493837	2.055744681
145	1	1	1	1	1	1	1	1
146	1.002450683	0.995868271	1.107283185	0.954236965	1.151462291	0.879827741	0.779770503	0.893973671	2.066718898
147	1	1	1	1	1	1	1	1	2.052066815
148	1	1	1	1	1	1	1	1	3.736595745
149	2.046806512	1.150699228	1.117668545	1.104712874	1.103981949	0.520005085	1.092700289	1.262147647	2.046806512
150	1	1	1	1	1	1	1	1	1.303950299
151	1	1	1	1.059042553	1.082659574	1.118723404	1.15606383	1.211170213	1.861489362
152	1.014561136	0.954693049	1.187620497	1.317848882	1.200510794	1.207835389 1.186150732	1.3595798	2.979270021
153	1	1	1	1	1	1	1	1	1.847659574
154	1.799857645	2.259353174	2.289247742	0.550818999	1.161042922	0.38256126	0.606381887	0.601176074	2.289247742
155	1.149895725	0.975755996	0.994873132	0.82848581	0.980609907	0.82848581	0.82848581	0.82848581	2.108840902
156	0.81440846	0.993985459	0.896034369	0.885783327	1.031574708	1.107209021	1.137011679	1.21240435	1.953288113
157	1.194933689	0.979931233	1.021051154	1.269401104	1.220344757	0.994958098	1.205082783	1.193976971	1.39010101
158	2.075178076	1.341419458	1.361615699	0.911821355	0.851128843	0.603695712	0.929604796	0.888621783	2.075178076
159	1.051520614	0.905448625	1.095249171	1.089247685	0.480412065	0.483532267	0.46555396	0.46555396	1.36195584
160	0.871277698	0.8938169	0.901091836	1.089558991	1.154412054	1.246174122	1.035918014	0.877414532	1.678366138
161	1.019750755	1.125755287	1.122715257	0.94847098	1.184044102	0.907655502	1.100977741	1.07077179	1.331130762
162	1.263199593	0.98409824	1.052402241	1.180607352	0.844846978	0.977505476	1.092168354	0.87118925	1.425106383
163	0.66366659	0.989451961	0.862187572	0.84862608	1.023521701	0.912200214	0.974366443	1.162952714	1.851088024
164	1	1	1	1	1	1	1	1	1.930609818
165	1.091263538	0.942021661	1.086209386	1	1	1	1.00787234	1.127553191	2.778617021
166	0.882930249	0.759726604	1.354130155	1.479853879	1.481325991	1.136415681	1.167929775	2.353197754	3.348297872
167	1.002578485	0.957296662	0.92736512	0.736106162	1.153931002	0.802796586	0.968809924	0.796568752	1.329722501
168	1	1	1	1	1	1	1	1	3.273465067
169	1.413705211	1.429709328	1.477305034	0.694962399	0.640429266	0.663531125	0.78467934	0.61208296	2.201754816
170	1.141556715	1.053697453	1.130817224	1.358615093	1.215309711	1.534703814	1.498945091	1.594644306	1.961022511
171	1.114949897	0.91140052	1.005263335	1.281909227	1.18767313	1.175953548	1.13365651	1.266940124	1.906395265
172	1	1	1	1	1	1	1	1	3.726504272
173	1.499105584	1.295071014	1.214487381	1.05031298	1.127685262	1.453171135	1.491516082	1.162749498	1.955285435
174	0.71211833	0.872443641	0.838913726	0.901401274	0.948127389	1.011617834	1.127184713	1.29666242	1.482873851
175	1	1	1	1	1	1	1	1.192659574	2.162234043
176	0.749487963	0.7302488	0.669475875	0.864461223	0.94092324	1.448076032	0.974104245	1.230710643	2.209748609
177	0.726639231	1.020164701	0.960415653	1.252649365	1.165814945	1.300496903	1.374991169	1.172061559	1.794082249
178	0.940955895	0.931670734	0.934349146	1.154078693	1.008832837	1.126163148	0.934155212	1.03693732	2.015173152
179	1	1	1	0.43510099	0.378208739	0.378208739	0.378208739	0.378208739	1.40664693
180	1	1	1	1	1	1	1	1	1.879859611
181	1.333272958	1.347340458	1.481434523	1.017318125	1.166504382	1.45646126	1.230143274	1.230143274	1.892535022
182	0.536340507	0.851448619	0.721757914	1.133832899	1.219121054	1.250543006	1.126303215	1.164422242	1.319656757
183	1	1	1	1	1	1	1	1
184	0.953092362	0.850921805	0.851693761	1.070617263	0.798910963	0.93699749	0.91325988	0.97792147	2.406007291
185	1.413815365	1.294207407	1.206937027	0.819414185	0.829512052	1.067953107	0.98623647	0.934675105	2.560057887
186	1	1	1	1	1	1	1	1	1.884574468
187	1.612879349	1.066740686	1.258419689	0.973113965	0.695699924	0.529378221	0.638295176	0.605875644	1.981808511
188	0.674788007	1.061023622	1.107495457	1.151817575	1.467092835	0.925331552	1.182902395	1.324720924	1.467092835
189	1	1	1	1.019680851	1.052234043	1.225957447	1.177234043	1.23893617	1.498051682
190	1	1	1	0.552892751	0.953350103	0.674777041	0.77
191	1.126273157	1.082712068	0.911302783	0.887236563	0.809656725	0.744848535	0.92
192	1	1	1	1	1	1	1	1	2.296382979
193	1	1	1	1	1	1	1	1	1.634620715
194	1	1	1	1	1	1	1	1	3.616584047
195	1.232454001	1.109377078	1.254134338	0.766189971	0.992131393	0.959095735	0.857116093	0.929557235	1.931276596
196	0.842488248	0.783179857	0.726254105	1.163404255	1	1.017234043	1	1	2.214255319
197	1	1	1	1	1	1	1	1	1.27534418
198	1	1	1.154042553	1	1	1	1	1	1.365944549
199	0.933875273	0.984166464	0.977008008	0.905458897	0.727193225	0.900073644	0.879821412	0.858970818	1.904251602
200	1	1	1	1	1.183617021	1.06	1.145531915	1	1.229148936
201	1.210638298	1	1	1	1	1	1	1	2.08610977
202	1.293357501	1.479579772	1.397039445	0.775781179	1.130994832	0.564247076	0.691721314	0.613565622	1.935078418
203	0.803766982	0.842151413	0.892483419	0.930527494	1.334435377	1.10590993	0.755993458	0.94989649	2.511369531
204	0.986151909	0.986151909	0.986151909	1.082562555	1.291792425	1.141660987	1.173692922	1.276409308	1.537994087
205	0.902935534	1.091233783	0.767593013	0.665300285	0.774355438	0.447279368	0.701311471	0.640718181	1.346461923
206	0.786714801	1.050180505	1.002815884	1.182959375	1.13689829	1.288820797	1.220816448	1.304240387	2.16675317
207	1.674072867	1.229884121	1.283098792	1.158412205	1.133477979	0.728875525	0.858227697	0.917851163	1.674072867
208	1.145021455	0.846717459	1.026943398	1.443313253	1.348192771	1.453975904	1.355	1.504337349	2.900652327
209	1.198992265	1.017528919	1.14292811	0.918295705	1.358067181	1.015556167	1.045223018	1.16127478	1.992785643
210	0.899657514	1.210238539	1.074265457	0.83900347	1.196414803	0.853556284	1.05247687	0.942029684	2.014665812
211	1.110540641	0.922677224	1.076209328	1.50258008	1.282835167	1.235030669	1.096679973	0.980722422	2.492109403
212	1.170779773	1.119048685	0.941998477	1.228270021	1.10841464	1.192957258	1.100193155	1.067505324	1.509186798
213	1.121282074	0.917251176	0.9323448461	1.062446809	1.145531915	1	1.090319149	2.874680851
214	2.167156674	1.367066211	1.156327741	0.922464714	0.93847268	0.58700654	1.260321819	1.31828846	2.167156674
215	0.894595516	0.749722956	0.893103742	0.784047042	0.607909148	0.939985636	0.733638567	0.634213125	1.888290713
216	1.430966721	1.135106166	1.374719273	0.91911847	0.634313122	0.726143864	0.656700973	0.74134411	1.430966721
217	1.244468085	1.025851064	1	1.112292149	0.989265418	0.989265418	0.989265418	0.989265418	1.49778506
218	1.651391217	1.269752833	1.05854541	1.054727552	1.111038199	0.888239974	1.492556167	1.397718045	1.829529882
219	1.637050459	1.114994421	1.269617027	1.062721255	1.011929672	1.045757827	1.117710924	1.070163317	1.637050459
220	1.092960365	0.912870785	0.967548382	1.006595745	1	1	1.00787234	1	2.378085106
221	2.509890018	1.383389788	1.672604859	1.020651943	0.717261273	0.470269696	0.578838395	0.649253203	2.509890018
222	1.072798515	1.20169107	0.992472675	1.343652398	1.426694837	0.919897116	1.686110601	2.009277972	2.009277972
223	1.107138377	0.917450759	1.035461883	0.86774263	0.841747364	0.979728857	0.895717667	0.844846137	2.722779739
224	1	1	1	1	1	1	1	1	1.845106383
225	1	1	1	1	1	1	1	1	2.239912281
226	0.951369633	0.945977054	0.990306065	0.932288099	0.959843697	0.967700645	1.317953913	1.244256838	1.317953913
227	0.973985671	1.046575482	0.991839393	1.21715227	1.355495657	1.060689685	1.587066273	1.640504	1.952521799
228	0.774532812	0.994263364	0.900521512	0.963913656	1.125621774	1.203660253	1.329845143	1.309103707	1.557648637
229	0.840711922	0.973794831	0.9932921921	1	1	1	1	1.015531915	2.417553191
230	0.634663426	0.821146445	0.841806765	1.206191843	1.024784764	1.195408296	1.022610662	1.027828507	2.046184739
231	1.145672314	1.202345737	1.253084011	0.841045809	1.24887873	1.250432537 1.113577684	1.186207378	1.355688771
232	1.027115554	1.004828111	1.042631621	0.956337067	0.690651203	1.06561544	0.945025199	0.687008957	2.557722769
233	1.018333636	1.138319114	1.380286803	1	1	1	1	1.155531915	1.854810375
234	1.205180267	0.967458706	1.011798277	1.198192889	1.086623453	1.286846068	1.245334905	1.147384273	1.815583517
235	0.856301572	0.894066491	1.0054439	1.175247841	0.915005508	1.075045304	1.181075223	1.053014959	2.102503912
236	0.817598831	1.099764591	0.97783911	0.881539097	0.856071035	1.026018722	0.917813877	0.989881608	1.099764591
237	0.817574143	0.961404497	0.853224402	0.981244801	1.158662936	1.162292974	1.173107464	1.261173712	1.899817343
238	0.954068437	0.865239232	0.785014424	0.712737127	0.827812908	0.429087624	0.588427181	0.471979658	1.807218908
239	0.703200508	0.769640737	0.606356833	0.88003569	1.542538479	1.037474905	1.545750613	1.743386125	2.018731028
240	1	1	1	1	1.011595745	1	1	1	1.632234043
241	1.455164586	1.153873439	1.267345346	0.90375666	0.838807581	0.916840898	1.043704053	0.986915762	2.06893617
242	1.03824547	0.894006473	1.041593809	0.852879883	0.770939565	0.911009622	1.075156298	1.00869064	1.781871649
243	1.244468085	1.121808511	1.172340426	0.857335835	1.145440901	0.705440901	0.956472795	0.821688555	1.738084941
244	1.242294838	0.872632752	0.909858893	0.636542997	0.693033382	1.145886248	0.650830007	0.614749637	2.592553191
245	1.251669465	0.987614251	1.219473979	1.294803991	1.522054414	0.965759773	0.974756011	2.121912655	2.121912655
246	1	1	1	1	1.001382979	1.049255319	1	1	1.971589857
247	0.876155438	0.804729056	0.891109067	1.439560139	1.567647783	1.598380611	1.22659135	1.306165714	2.056549098
248	0.798483755	0.932924188	0.960794224	1	1.072553191	1.177659574	1	1.099680851	1.889574468
249	1.065886486	0.896976595	0.822529566	1.078098162	1.134853634	1.19906443	1.022475606	1.016628294	2.405414593
250	0.962249759	1.027351412	1.128693297	1.252803984	1.092804794	1.058387658	1.045167429	1.144268535	1.975155022
251	1.866066373	1.220552694	1.179411399	0.839070905	0.785469787	0.717513098	1.168529514	1.14195599	1.866066373
252	1.376315028	0.926551491	0.96293794	1.156914894	1	1	1	1	2.098133432
253	0.982539056	0.993686955	0.862482559	1.031549865	0.803303526	1.057306675	0.893470518	0.782762115	2.08862671
254	1.160570142	0.879960065	1.098776447	1.136534879	0.735996688	0.989443179	0.776940592	0.888408197	1.94684466
255	0.987666751	0.828844702	0.843342562	0.739096386	0.886987952	0.761144578	0.867951807	0.851144578	1.776382979
256	0.795516313	0.941672713	0.866657648	1.049613754	0.948525176	1.061873181	1.081163316	1.006838693	1.667059301
257	1.119442509	0.926202091	1.087595819	1.08330562	0.752710343	1.252909877	1.008014633	0.885700033	2.331692436
258	1.84064493	1.557723876	1.458479565	0.957369127	0.96507268	0.49043305	0.737514866	0.596320928	1.84064493
259	0.627880569	0.899405517	0.96640171	0.853819664	0.874060018	0.841801954	1.012579942	0.969147516	1.450548454
260	1.401382887	1.407951599	1.318121579	1.088138059	1.53577096	1.387926474	1.338799259	1.217865644	1.638737098
261	1	1	1	1	1	1	1	1	1.339042553
262	0.796473838	0.964671906	1.117196502	1.449473451	1.147811145	1.471121178	1.286939769	1.63522995	2.889815091
263	1.334690044	0.975787936	0.991129201	0.586637012	0.505353908	0.485818449	0.4361085	0.457478275	1.518343195
264	1.207221123	1.142057248	1.096876961	1.263687322	0.976349535	1.074867542	1.098825155	0.920909161	2.093297872
265	0.943635304	0.913741625	0.909736382	0.903934035	0.96830916	1.083316776	0.991919995	0.766507716	2.121435958
266	1.159148936	1	1	1	1	1	1	1	2.042978723
267	1	1	1	1	1	1	1	1	1.847456109
268	1.017765957	1	1	0.950356189	0.697536361	0.697536361	0.697536361	0.697536361	1.378723404
269	1.148400253	1.006146246	1.098426101	1.072358253	1.013300252	1.037338323	1.097535183	0.976978768	1.874264912
270	1.017765957	1	1	1	1	1	1	1	1.84393617
271	0.699567445	0.89468517	0.927066188	0.777698637	1.081814202	1.072191184	0.90016397	0.947789377	1.693486302
272	0.901351244	0.951657862	0.869627545	0.941124955	1.196847259	0.984156682	1.095776442	1.107360376	1.64067324
273	0.754026388	0.919563239	0.836055505	1.034670616	0.865488337	1.006290163	0.957830098	0.859456302	3.405015674
274	1.317195735	1.190433877	0.855650202	1.181199852	1.28707461	1.142073227	1.148436779	1.065572259	1.771291315
275	1.143878484	1.535289801	1.443344438	0.984009633	1.210015451	0.671815522	0.79438244	0.874019214	1.899023036
276	1.068736617	0.862098501	0.925910064	0.888636793	1.06957837	1.027509926	0.914539611	1.026848175	2.613085106
277	1.228246124	1.422432171	1.335319767	0.646052277	0.647130154	0.625202102	0.656628941	0.755557801	1.823438618
278	1.053617021	1	1	0.868208092	0.863904945	0.723956326	0.755234425	0.731213873	1.342655468
279	0.58435907	1.128061669	1.111463384	1.18287234	1.133191489	1.473085106	1.082021277	1.006170213	2.055924822
280	0.981985137	0.862417805	0.922532197	1.173635437	0.969715781	1.055025939	0.964306301	1.068593979	3.269387173
281	1.082250133	1.004792182	2.144078679	1.584627667	1.820365801	1.118304543	1.003266076	2.923210916	3.73372093
282	0.900705523	0.946303827	0.960414277	1.210673317	1.225735661	1.274413965	1.245985037	1.126683292	2.055744681
283	0.874783814	1.300143331	1.561063716	1.080958583	1.698515238	1.549494949	1.217359845	1.453717693	2.139577128
284	0.736009098	0.980002843	0.900061603	0.803849001	0.74495083	1.039124458	0.766892249	0.813418632	2.540314704
285	1.66712766	1.126382979	1	0.918255964	0.576439566	0.576439566	0.66032992	0.576439566	1.66712766
286	1.271899225	1.101162791	1.166957364	0.94809531	0.923761825	1.186371225	1.109627156	1.231243993	1.862969973
287	1.004245661	1.075723548	1.005197959	1.153857565	0.831477223	0.751433143	0.809140326	0.625814587	1.868884868
288	0.910536655	1.104056877	1.213664286	1.359450663	1.109258818	1.805403403	1.446323199	0.966579344	1.805403403
289	1.048423862	0.935564574	0.980652694	0.850258626	0.898710142	0.982518169	0.866627382	0.863942906	2.26486698
290	1	1	1	0.517398509	0.743533094	0.692994569	1.031022738	0.776535027	5.887659574
291	1.201723264	1.077648251	1.143233654	0.973741442	1.00177205	1.184373741	0.859363673	0.790173178	1.867021277
292	0.772963128	0.971652159	0.87460025	1.265677813	1.169073337	1.521081193	1.211824901	1.089813427	2.334948374
293	0.724219044	0.909202108	0.897299586	1.125433526	1.33879255	1.354527938	1.086769428	1.28657675	2.012842012
294	0.796014266	0.844771603	0.873797631	0.742983745	1.124862593	0.915522827	0.769570124	1.010486687	2.051979526
295	1	1	1	0.660833333	0.489583333	0.489583333	0.489583333	0.489583333	1.564574468
296	1	1	1	0.656141792	0.551675568	0.551675568	0.551675568	0.551675568	2.137446809
297	1.547553191	1	1	1	1	1	1	1	1.836595745
298	0.967415431	1.117286691	1.069519666	1.206153634	1.148403084	1.570278084	1.283039648	1.329019824	2.436489362
299	0.866376639	0.978423324	1.30878621	1.360718434	1.406919149	2.072139303	1.615731913	1.313761589	3.832765957
300	1	1.266914894	1.10787234	0.78608463	1.163070748	0.78608463	1.582622512	1.146178291	1.582622512
301	0.847071309	0.640268863	0.879264163	0.561557142	0.735398729	0.673976501	1.004783281	0.916586945	7.937691573
302	0.738377393	0.859552025	0.932673525	1.694452738	1.38191915	1.5752075	1.387352959	1.424852212	2.739893617
303	0.648374627	0.877563935	0.899822536	1.054658326	1.028185429	1.332373998	1.094450919	1.005589515	2.266663125
304	1	1	1	0.583196469	0.546704989	0.783104085	0.532282899	0.65089304	1.227978723
305	1.516920396	1.226428298	1.100954619	0.874163451	0.801830382	0.749271501	1.216437795	1.157418216	1.8983562
306	1.09470128	1.406614509	1.251066856	0.767113863	1.287502315	0.696753195	1.078193221	0.821835887	1.497403983
307	1.463124504	1.026962728	1.141356067	0.94924916	0.952056834	0.905560046	0.736121155	0.759348279	2.605579263
308	1.622765957	1	1	0.946885035	0.939884393	0.882851638	1.018754014	0.803468208	7.322340426
309	0.834870849	0.915883932	0.911942301	0.950795084	1.417248802	0.96466912	1.063009513	1.165224637	1.424699056
310	1.115906085	0.878417108	0.887621252	0.97611523	0.834204449	0.887504558	0.981585025	0.868907257	1.960790415
311	1	1	1	1	1	1	1	1	2.115869757
312	0.772078827	1.053977838	0.928836839	0.793874602	0.924534944	0.856444082	0.809401171	0.841362188	2.349255319
313	1.517021277	1.30287234	1.281489362	1.013085106	1.193617021	1	1	1	1.517021277
314	1	1	1	0.508520422	0.508520422	0.508520422	0.508520422	0.508520422	1
315	1.502012953	1.182128479	1.430859443	0.967213115	0.900940098	0.864035428	0.797995494	0.7850439	1.602990033
316	1	1	1.061382979	1	1	1	1	1	1.947464923
317	1.089255319	1	1	1	1	1	1	1	1.298978644
318	1	1	1	0.62767094	0.62767094	0.62767094	0.62767094	0.62767094	1.848085106
319	1.073750127	1.365496099	1.721955047	0.87741338	1.90035469	1.468121538	1.553928678	1.961560638	2.147474858
320	1.800827182	1.857899742	1.590197588	0.6011213	0.412334299	0.209768613	0.437249964	0.341065235	2.011456777
321	2.802410519	3.130314098	2.002629657	1.104713506	0.991794489	1.02918551	0.886754627	0.933936314	3.130314098
322	1.017765957	1	1	0.62767094	0.62767094	0.62767094 0.62767094	0.62767094	1.846919302
323	1.193873269	1.002622744	0.986151909	1	1.123191489	1	1	1.034255319	2.316515945
324	1.028673871	1.034857075	1.244394619	0.872382213	0.942248704	1.288149619	0.864603332	1.188657178	2.252585097
325	1.263961187	0.866730682	0.999747309	0.822128702	0.765075645	0.876997656	0.855263158	0.783986789	2.180522826
326	1.018396434	1.233000565	1.147610975	0.885882745	1.31558176	0.858874994	1.051828254	0.879653844	1.573032344
327	1.441606413	0.909226658	0.879597611	0.915198131	0.915198131	0.915198131	0.915198131	1.066425859	1.528617021
328	1.397901857	1.534395781	2.070196056	1.226155733	1.50040181	1.379604957	1.247980375	1.283551157	2.356788133
329	1	1	1	1	1	1	1	1	2.1252123383
330	0.91811369	0.906009464	0.91267085	0.953153368	0.887496652	1.252299176	1.070359237	0.919670228	3.084566118
331	1	1	1	1	1.04212766	1	1	1	1.198344407
332	1.02271685	1.166264102	1.056685113	0.772114839	1.345323096	0.757535924	1.087443611	1.031966062	1.525632104
333	1.141808511	1	1	0.54184352	0.332484437	0.332484437	0.332484437	0.332484437	1.164468085
334	0.890270666	0.952542063	1.054773226	1	1.163510638	1	1	1	1.915106383
335	1	1.035	1.033297872	0.552071122	0.501807347	0.459163736	0.459163736	0.459163736	1.711688784
336	0.868522484	0.946181299	0.919985724	1.160187842	0.817462388	1.024089051	1.202104531	0.944603879	4.114859813
337	1.228994684	1.023059246	1.014892841	1.161584251	1.063516345	1.070017625	0.872767783	1.125070666	2.239192302
338	0.779467681	0.854195039	0.765522351	1.407078741	1.267912737	1.369742075	1.279377343	1.309601182	1.969918675
339	0.54605594	0.902394677	0.879105575	1.121718065	1.795194133	1.205526092	1.338047535	1.588293066	1.795194133
340	0.91445144	0.987551551	0.86244321	0.740083314	0.99710694	0.828665715	0.813208929	0.944476918	2.242061507
341	0.80786679	0.953809671	0.880296938	1.032677978	0.974055122	1.360220846	0.972035192	0.996139689	2.539557286
342	1.198477009	0.846919848	0.758322757	1.246484086	1.034830167	1.184513529	1.224401678	1.06591825	2.224170182
343	1.460210155	0.806304651	0.713718863 1	1	1	1	1	1.557351753
344	0.964386792	0.898820755	0.915978774	0.959186702	1.283689522	1.012540813	1.105224102	1.166295637	2.29122733
345	0.7148567	0.844718197	0.910898504	1.463194311	1.488966156	1.477993465	1.362780214	1.561931054	2.115540522
346	1.909893617	1.057872341	1.085212766	1.102978723	1	1.198297872	1	1.909893617
347	1.003190868	0.880814345	1.072356299	0.897957921	0.803960396	0.825618812	0.703155941	0.639665842	1.847992236
348	1.066872149	0.97531747	1.190062878	0.987956013	1.133317818	0.977075697	0.858943775	0.980954597	1.974879917
349	1.118065108	0.924438331	1.097294819	0.985637657	1.022469554	0.957472088	0.817535338	1.041933849	1.985113083
350	1.387174997	1.092738785	1.083093089	0.91083237	0.979242653	1.084304481	0.998754559	1.201405569	1.8
351	1.709242784	1.193580685	1.002460165	0.932237085	0.816364204	0.380335691	1.011416887	0.949504416	2.261063261
352	1	1	1	1	1.28606383	1.143297872	1	1	1.503085106	1.503085106
353	1	1	1.199787234	1.197776806	0.947542622	1.208767876	1.128395679	0.808030975	1.943297872
354	1.135135135	0.98540238	0.905960065	1.015951779	0.87506469	0.607385309	0.788304058	0.663429633	1.436937879
355	0.686164595	1.03285633	0.903833432	0.648813898	1.16167316	0.875455793	0.981213693	1.072663496	1.201913442
356	1	1	1	1	1	1	1	1	1.867021277
357	0.88360404	1.201796435	1.075254805	0.634219197	0.743879531	0.66615342	0.729713916	0.769008099	1.618989618
358	1	1	1	0.984644592	1.282818695	1.355910436	1.389804009	1.30135686	2.656492544
359	1	1	1	1	1	1	1	1	1.859574468
360	0.833154982	1.110526799	0.960834072	1.080841669	1.038022296	1.142849355	1.086974297	1.115211644	1.357630358
361	0.864465799	0.944717378	0.951492739	1.46970117	1.221017908	1.399318068	1.17026113	1.216443976	3.190718592
362	0.743494424	1.008700467	0.858024203	1.127217125	1.267787971	1.164424057	1.117940877	1.142813456	1.267787971
363	1	1	1	1	1	1	1	1	3.235425532
364	0.827611891	0.863374614	0.802143318	0.903736627	0.74858649	0.863259083	1.044384723	0.665874205	1.791358517
365	1.071489362	1.099042553	1.042659574	1.18287234	1.031914894	1.06	1.198297872	1.015531915	1.7483877097
366	1	1	1	1.020552344	1.25613359	1.433590238	1.15433526	1.573281952	2.259707193
367	0.711997477	0.78493178	0.768001195	1.040069409	0.90072593	1.357472618	1.191129648	1.173522669	2.114286534
368	1	1	1	1	1	1	1	1	2.150044085
369	0.759793671	0.938630977	0.862456434	0.972080028	0.994004038	1.205127159	1.191034609	1.072910081	4.27175051
370	1.57453322	1.356098643	1.302717492	1.062281282	1.093525553	1.24456942	1 .047538004	0.932242302	2.595615003
371	1.072189728	1.227946479	1.205352135	0.766533475	0.766533475	0.816602789	0.910462366	0.892848406	1.278343081
372	1.779403382	1.459908797	1.645259358	0.682563714	0.89822525	0.588695433	0.671124569	0.558541509	1.779403382
373	0.716081359	0.942637312	0.846042508	1.069335239	1.57692995	1.196568978	1.443084346	1.587651894	2.166276596
374	1.199953293	1.059831854	0.978701541	1.103592248	0.861430597	0.96608634	1.16925319	1.033480384	1.929473433
375	1.169293409	0.896377979	1.199151752	1.007031598	1.171384068	0.774032043	0.612527815	0.983622608	2.234498475
376	1.04996117	1.056777979	1.212787989	0.943159923	0.986062942	0.801734104	0.767951188	0.831021195	1.93501115
377	1.080735412	1.119765058	0.957877177	0.743297566	0.867850473	0.675339474	0.688380337	0.70999905	1.915590267
378	0.94493137	0.777034803	0.912809884	0.641521117	0.4714333	0.355468583	0.252481648	0.566878906	1
379	1	1	1	1	1	1	1	1	2.194099834
380	0.82255303	0.891229906	0.925853705	0.976414891	1.006929202	1.028233269	0.867398321	0.778738971	1.934825035
381	1	1	1	1		1	1	1	6.955212766
382	0.773165896	0.848446794	0.835228024	0.936721728	0.862092334	1.237018213	0.827869547	0.796272766	1.580106383
383	0.687036906	0.976642439	0.844047703	0.875885203	1.176108833	1.069139023	0.984811778	1.173686172	3.240602166
384	1	1	1	1	1.123191489	1	1	1.303404255	1.433004158
385	0.737497635	0.877719619	0.887368355	1.15385234	1.036244705	1.34389577	1.147954533	1.191491073	2.005849966
386	0.646593945	1.055209261	0.968239834	0.957858255	1.306042493	1.041890602	1.05952082	1.098648852	1.829488465
387	1.021246344	1.102353013	0.99348459	1.078375967	1.103036612	0.918838895	1.565018117	1.341280893	1.565592001
388	0.88612368	0.88612368	0.88612368	0.834412436	0.630571455	1.146757999	0.897657252	0.763723374	3.199516212
389	0.952863659	0.952863659	0.952863659	1	1.193617021	1	1	1.052978723	2.160636183
390	1.061572453	0.969276305	0.937760547	0.942207265	0.884240455	1.023151909	0.938725775	0.912556574	1.964051968
391	1	1	1	1	1	1	1	1	1.709526136
392	0.627583943	0.962766272	1.011369679	1.103367342	1.21882135	1.142357618	1.18998579	1.209433028	1.301790471
393	1.427132701	1.188684834	1.250592417	0.748587363	0.966903941	1.237543113	1.192338739	1.681147721	1.681147721
394	2.359800149	1.718992641	1.529066235	0.929832768	0.905430164	0.608505828	0.756207851	0.777764784	2.359800149
395	1	1	1	1	1	1	1	1	2.042765957
396	1	1	1	1	1	1	1	1	2.3688923
397	1.354947775	0.922840065	0.853589326	1.250662589	1.191641182	1.092558614	1.208766565	1.124974516	1.581131544
398	1.040114326	1.35270521	1.124103696	1.391611118	1.637274393	1.378513234	1.591743656	1.673059681	1.673059681
399	0.820279246	0.748987271	0.761345644	0.936766312	1.288493038	1.043987169	1.00996451	1.12465875	2.046190397
400	0.937188435	0.937188435	0.937188435	1.014633836	1.03906598	1.291467837	1.082712986	1.120188331	1.954148936
410	1	1	1	1	1	1	1	1.090319149	2.033727592
402	1	0.926659063	0.973127939	0.872309105	0.697975742	0.686815505	0.464098545	0.717216693	1
403	1	1	1	1	1	1	1	1	2.635141623
404	1.079420019	0.994480823	1.134705332	1	1.011595745	1.129468085	1	1.275851064	1.849148936
405	1.261271141	1.096042306	1.294779939	1.106045922	1.001480202	1.201325133	1.221889372	1.006061781	1.481142714
406	0.769099277	0.838461538	0.841880342	0.958205912	1.162895005	0.958205912	0.965749235	1.089398573	1.805638298
407	1	1	1	1	1.011595745	1	1	1.043617021	1.238758251
408	1	1	1	1	1	1	1	1	3.180443147
409	0.866921683	0.859707152	0.85909311	1.11047861	0.951699463	1.11047861	1.11047861	1.01601536	1.111936029
410	1	1	1.052446809	2.281276596	1.868404255	1.759148936	1.583510638	2.281276596
411	1.320499623	1.093816485	1.292636058	1.098297872	1	1.011914894	1	1.006170213	1.868606199
412	1	1	1	1	1	1	1	1	1.07477641
413	1	1	1	1	1	1	1	1	1.816303024
414	0.843774481	0.887145401	0.880545994	1.18847045	1.107964173	1.324549573	1.310059826	1.22198015	2.134586036
415	1.162773534	1.09509576	1.006310196	0.736155759	0.765694183	0.742342452	0.8100928	0.626978832	2.034803032
416	0.679366408	0.971530249	0.97494941	1.076604118	0.938927542	1.08995713	1.074003795	1.022559561	2.041276596
417	0.591414614	0.878754807	0.853861345	1.151216609	1.097328749	1.400952129	1.163118223	1.104601957	2.185061528
418	0.769526277	0.848212092	0.979920934	1.211142695	0.867879477	1.227743036	1.042455941	1.074792496	2.999187747
419	0.842346904	1.10073594	1.092836405	1.282111488	1.065310027	1.094356031	1.18505957	1.323419428	1.680040323
		AM		AM		AM		AM
	1	min	1	min	1	min	1	min
	2	0.617720674	49	0.27783982	96	0.657987256	143	0.602525479
	3	0.975882179	50	0.602448247	97	0.382084802	144	0.604985472
	4	0.374159137	51	0.384386423	98	0.338017625	145	0.461479624
	5	0.434105083	52	0.451640801	99	0.893026791	146	0.57766974
	6	0.499975309	53	0.366885023	100	1	147	0.49659253
	7	0.493257071	54	0.757270603	101	0.638500204	148	1
	8	0.643130816	55	0.712224067	102	0.679807998	149	0.189006771
	9	0.750773905	56	0.872632752	103	0.747921832	150	0.54598338
	10	0.395613834	57	0.79459618	104	0.685190305	151	0.936161737
	11	0.770591549	58	0.6006124	105	0.477289307	152	0.562493219
	12	0.580658633	59	0.855115112	106	0.813003946	153	1
	13	0.68949596	60	0.669166917	107	0.558380572	154	0.129959906
	14	0.80129047	61	0.449564477	108	0.677042676	155	0.640803312
	15	0.720711954	62	0.576620499	109	0.470047005	156	0.609360819
	16	1	63	0.48107104	110	0.647026432	157	0.522579204
	17	0.699456805	64	0.312010272	111	0.685770313	158	0.362416767
	18	0.716511794	65	0.253919966	112	0.324518401	159	0.46555396
	19	0.692804106	66	0.602417457	113	0.305283129	160	0.648650284
	20	0.501467058	67	0.776800864	114	0.412230029	161	0.336123336
	21	0.65582404	68	0.497450765	115	0.287437055	162	0.433025559
	22	0.534945144	69	0.496881277	116	0.547455016	163	0.562022224
	23	0.394132914	70	0.748288489	117	0.434842948	164	1
	24	0.46631031171	71	0.365505203	118	0.387965671	165	0.861169898
	25	0.448302175	72	0.399300334	119	0.49564269	166	0.545835251
	26	0.773545221	73	0.395935179	120	0.767008097	167	0.429089161
	27	0.736030759	74	0.756478352	121	1	168	0.863502705
	28	0.551247861	75	0.670402612	122	0.753109815	169	0.390472833
	29	0.689691105	76	0.670934199	123	0.401368018	170	0.744555027
	30	1	77	0.743553235	124	1	171	0.897061304
	31	0.529070749	78	0.781681497	125	0.384505256	172	0.988002181
	32	0.52713633	79	0.751830581	126	0.474651586	173	0.520525452
	33	0.228436886	80	0.499550979	127	0.215310085	174	0.447567811
	34	0.669884546	81	0.515803336	128	0.723447772	175	0.877684407
	35	0.320223641	82	1	129	0.963806008	176	0.669475875
	36	0.894378651	83	0.707405178	130	0.677427259	177	0.419926014
	37	0.555065854	84	0.587066076	131	0.309265271	178	0.735483302
	38	0.358184612	85	0.293988866	132	0.558485656	179	0.378208739
	39	1	86	0.591317099	133	0.370794052	180	0.494470842
	40	0.53972894	87	0.723738504	134	0.214881701	181	0.450794404
	41	0.716081359	88	0.404818059	135	0.826594261	182	0.220388258
	42	0.503253302	89	0.5147789	136	0.446090585	183	0.540766551
	43	0.55864057	90	0.556552798	137	0.485863441	184	0.798910963
	44	0.709172555	91	0.755960401	138	0.515803336	185	0.425252618
	45	0.930600931	92	0.700735655	139	0.654130134	186	0.864769686
	46	0.585746033	93	0.786977492	140	0.266284397	187	0.529378221
	47	0.806988969	94	0.799574065	141	0.4427342	188	0.29353339
	48	0.194584748	95	0.693984525	142	0.444107358	189	0.35295324
		AM		AM		AM		AM		AM
	1	min	1	min	1	min	1	min	1	min
	190	0.552892751	237	0.758157046	284	0.597972935	331	0.511926805	378	0.252481648
	191	0.509159097	238	0.402978098	285	0.452363537	332	0.378309811	379	1
	192	1	239	0.606356833	286	0.648215892	333	0.332484437	380	0.587932629
	193	0.308267346	240	0.556938026	287	0.442389849	334	0.467057538	381	0.172698879
	194	0.884632717	241	0.838807581	288	0.69163417	335	0.459163736	382	0.445683898
	195	0.551287315	242	0.335910908	289	0.621766437	336	0.577861844	383	0.506510235
	196	0.726254105	243	0.15105012	290	0.517398509	337	0.46292613	384	0.344836285
	197	0.42560609	244	0.557855078	291	0.546225767	338	0.610106902	385	0.626518866
	198	0.533936202	245	0.727936174	292	0.680963117	339	0.422928102	386	0.440755849
	199	0.62401015	246	0.907906227	293	0.580263483	340	0.611884939	387	0.433022751
	200	0.558559629	247	0.804729056	294	0.738023298	341	0.689945904	388	0.630571455
	201	0.756478352	248	0.721080086	295	0.489583333	342	0.687276256	389	0.630957175
	202	0.175626909	249	0.814464609	296	0.551675568	343	0.44078182	390	0.884240455
	203	0.506079468	250	0.631698186	297	0.73151751	344	0.621230121	391	0.459208598
	204	0.553722903	251	0.548784249	298	0.82673197	345	0.627326099	392	0.544781894
	205	0.336076818	252	0.715100799	299	0.594965599	346	0.327937483	393	0.45538223
	206	0.665387843	253	0.680674967	300	0.419221373	347	0.624469247	394	0.480167057
	207	0.236429103	254	0.735996688	301	0.472338073	348	0.728834893	395	1
	208	0.624969	255	0.525051826	302	0.738377393	349	0.817535338	396	1
	209	0.683054298	256	0.497034721	303	0.648374627	350	0.645352892	397	0.516248974
	210	0.390673704	257	0.717037778	304	0.532282899	351	0.358372728	398	0.549846837
	211	0.741461145	258	0.202296504	305	0.444067596	352	0.304907717	399	0.65972613
	212	0.557173245	259	0.436500972	306	0.315068933	353	0.75365	400	0.666051979
	213	0.598293009	260	0.381803575	307	0.718215812	354	0.359324957	401	0.915109034
	214	0.456645908	261	0.340460584	308	0.593494116	355	0.393581046	402	0.464098545
	215	0.607909148	262	0.796473838	309	0.509321345	356	1	403	1
	216	0.504449319	263	0.4361085	310	0.590813094	357	0.528711619	404	0.629888348
	217	0.410367452	264	0.863172582	311	0.587056544	358	0.487956811	405	0.33895512
	218	0.425422724	265	0.687687688	312	0.474594392	359	1	406	0.489437371
	219	0.373219281	266	0.681356915	313	0.22932982	360	0.499916185	407	0.385313531
	220	0.613000421	267	0.784313725	314	0.508520422	361	0.812983789	408	1
	221	0.234759372	268	0.53946088	315	0.416349019	362	0.541568008	409	0.493831628
	222	0.563481 597	269	0.348793238	316	0.586489527	363	1	0.52660431	410	0.560583312
	223	0.404874069	270	0.942544871	317	0.451528634	364	0.52660431	411	0.680095244
	224	1	271	0.080946558	318	0.62767094	365	0.543667149	412	0.538219296
	225	0.324238557	272	0.382358758	319	0.496851701	366	0.441336067	413	0.8358868
	226	0.212409869	273	0.658920874	320	0.163060943	367	0.489400859	414	0.754236235
	227	0.210617132	274	0.541104912	321	0.101068748	368	1	415	0.626978832
	228	0.547898493	275	0.123670821	322	0.475236278	369	0.713372638	416	0.679366408
	229	0.791778976	276	0.782523969	323	0.525896759	370	0.582719279	417	0.591414614
	230	0.634663426	277	0.625202102	324	0.682514738	371	0.347890452	418	0.644690782
	231	0.378419422	278	0.527003795	325	0.347704715	372	0.44009551	419	0.550725293
	232	0.600271657	279	0.58435907	326	0.415432023	373	0.388333471
	233	0.884189508	280	0.862417805	327	0.468477448	374	0.272697033
	234	0.44825685	281	0.681634155	328	0.484884222	375	0.406168567
	235	0.582589908	282	0.754535238	329	0.802321611	376	0.767951188
	236	0.550187401	283	0.381947134	330	0.7546261	377	0.625584235

Claims

1. A polynucleotide microarray comprising at least one polynucleotide set forth in Table 1, Table 2, Table 3 or Table 4, wherein expression of said polynucleotide is either increased or decreased in brain cells in response to stress compared to normal brain cells.

2. A method for screening a compound for effectiveness in altering expression of a target polynucleotide wherein said target polynucleotide comprises a polynucleotide selected from Table 1, Table 2, Table 3 or Table 4, wherein said polynucleotide expression is either increased or decreased in brain cells in response to stress compared to normal brain cells.

3. A method of treating depression in a mammal comprising administering a compound identified in the method of claim 2.