Claims
- 1. A compound represented by 1:
- 2. The compound of claim 1, wherein X represents independently for each occurrence a bond or O.
- 3. The compound of claim 1, wherein X represents O.
- 4. The compound of claim 1, wherein Z represents independently for each occurrence alkylsulfonyl, fluoroalkylsulfonyl, arylsulfonyl, or S(O)2OH.
- 5. The compound of claim 1, wherein Z represents independently for each occurrence methylsulfonyl, trifluoromethylsulfonyl, or S(O)2OH.
- 6. The compound of claim 1, wherein Ar and Ar′ represent independently for each occurrence optionally substituted aryl.
- 7. The compound of claim 1, wherein Ar and Ar′ represent independently for each occurrence optionally substituted phenyl or naphthyl.
- 8. The compound of claim 1, wherein X represents O; and Z represents independently for each occurrence alkylsulfonyl, fluoroalkylsulfonyl, arylsulfonyl, or S(O)2OH.
- 9. The compound of claim 1, wherein X represents O; and Z represents independently for each occurrence methylsulfonyl, trifluoromethylsulfonyl, or S(O)2OH.
- 10. The compound of claim 1, wherein X represents O; Z represents independently for each occurrence alkylsulfonyl, fluoroalkylsulfonyl, arylsulfonyl, or S(O)2OH; and Ar and Ar′ represent independently for each occurrence optionally substituted aryl.
- 11. The compound of claim 1, wherein X represents O; Z represents independently for each occurrence methylsulfonyl, trifluoromethylsulfonyl, or S(O)2OH; and Ar and Ar′ represent independently for each occurrence optionally substituted aryl.
- 12. The compound of claim 1, wherein X represents O; Z represents independently for each occurrence alkylsulfonyl, fluoroalkylsulfonyl, arylsulfonyl, or S(O)2OH; and Ar and Ar′ represent independently for each occurrence optionally substituted phenyl or naphthyl.
- 13. The compound of claim 1, wherein X represents O; Z represents independently for each occurrence methylsulfonyl, trifluoromethylsulfonyl, or S(O)2OH; and Ar and Ar′ represent independently for each occurrence optionally substituted phenyl or naphthyl.
- 14. The compound of claim 1, wherein T represents —C(O)NR—Q—NRC(O)—; Q is —(CH2)n— or heterocyclyl; and n is an integer selected from the range 2 to 10 inclusive.
- 15. The compound of claim 1, wherein T represents —(CH2)—NR—Q—O—; and Q represents alkyl, cycloalkyl, or heterocyclyl.
- 16. The compound of claim 1, wherein T represents —(CH2)—NR—Q—O—C(O)— or —(CH2)—NR—Q—O—C(O)—(CH═CH)—; and Q represents alkyl, cycloalkyl, or heterocyclyl.
- 17. The compound of claim 1, wherein T represents —(CH2)—NR—Q—; and Q is a bond, alkyl, or heterocyclyl.
- 18. The compound of claim 1, wherein T represents —CH2CH(C(O)NHMe)—NRC(O)—Q—C(O)NR—G—; Q is alkyl, cycloalkyl, cycloalkenyl, heterocyclyl, alkenyl, aryl, heteroaryl, aralkyl, alkyl-O-alkyl, or alkyl-S-alkyl; and G is a bond, alkyl, or heterocyclyl.
- 19. A composition, comprising a compound of claim 1; and an acceptable excipient.
- 20. A combinatorial library, consisting of a plurality of compounds of claim 1.
- 21. A method of inhibiting adhesion to a surface by a bacterium, fungus, virion, freshwater invertebrate, or marine invertebrate, comprising the step of treating a surface with an effective amount of a compound of claim 1.
- 22. A method of enhancing adhesion to a surface by a bacterium, fungus, virion, freshwater invertebrate, or marine invertebrate, comprising the step of treating a surface with an effective amount of a compound of claim 1.
- 23. The method of claim 21 or 22, wherein said surface is a portion of an exterior surface of an aquatic vessel.
- 24. The method of claim 20 or 21, wherein said surface is a portion of an exterior surface of an off-shore platform.
- 25. The method of claim 20 or 21, wherein said surface is a portion of an exterior surface of a harbor infrastructure.
- 26. The method of claim 20 or 21, wherein said surface is a portion of an exterior or interior surface of a conduit for water or an aqueous solution.
- 27. The method of claim 20 or 21, wherein said surface is a portion of an exterior surface of a cable. In certain embodiments, said surface is a portion of an exterior or interior surface of a laboratory apparatus.
- 28. The method of claim 20 or 21, wherein said surface is a portion of an animal cell membrane. In certain embodiments, said surface is a portion of a mammalian cell membrane.
- 29. The method of claim 20 or 21, wherein said surface is a portion of a human cell membrane.
- 30. The method of claim 20 or 21, wherein said surface is a portion of an exterior surface of a plant.
- 31. The method of claim 20 or 21, wherein said surface is a portion of an exterior surface of a plant component.
- 32. The method of claim 20 or 21, wherein said surface is a portion of the cell membrane of a fungus. In certain embodiments, said surface is a portion of the cell wall of a fungus.
- 33. The method of claim 20 or 21, wherein said surface is a portion of the cell membrane of a bacterium.
- 34. The method of claim 20 or 21, wherein said surface is a portion of the cell wall of a bacterium.
- 35. The method of claim 20 or 21, wherein said surface is a portion of a virion protein coat.
- 36. The method of claim 20 or 21, wherein said surface is a portion of a virion envelope.
- 37. The method of claim 20 or 21, wherein said surface is a portion of a filter for water or aqueous solutions.
- 38. The method of claim 20 or 21, wherein said surface is a portion of an exterior surface of an implantable medical device.
- 39. The method of claim 20 or 21, wherein said surface is a portion of an exterior surface of an insertable medical device.
- 40. The method of claim 20 or 21, wherein said surface is a portion of a food processing surface.
RELATED APPLICATIONS
[0001] This application claims the benefit of the filing date of U.S. Provisional Patent Application Ser. No. 60/194,333, filed Apr. 3, 2000.
Provisional Applications (1)
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Number |
Date |
Country |
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60194333 |
Apr 2000 |
US |