Genes and gene products related to Werner's syndrome

TECHNICAL FIELD
The present invention relates generally to Werner's Syndrome and more specifically to methods and compositions suitable for use in diagnosis and treatment of Werner's Syndrome.
BACKGROUND OF THE INVENTION
Werner Syndrome (WS) is an autosomal recessive disorder with a complex phenotype. The disorder manifests itself in premature occurrence of age-related diseases and premature appearance of some of the physical features of normal aging. The onset of symptoms usually occurs after adolescence. The disorder progresses throughout life and typically patients have a shortened life expectancy with a modal age of death at 47. The prevalence of Werner Syndrome is estimated for heterozygotes to be 1-5 per 1,000 individuals, and for homozygotes to be 1-22 per 1,000,000 individuals.
Clinical symptoms of Werner Syndrome include both a prevalence of age-related diseases and physical features of aging. Such diseases include arteriosclerosis and heart disease, both benign and malignant neoplasms (usually sarcomas), diabetes mellitus, osteoporosis, and ocular cataracts. The physical appearance of WS patients is often manifest as a short stature, premature graying or loss of hair, hypogonadism, altered skin pigmentation, hyperkeratosis, tight skin, bird-like facies, cutaneous atrophy, cutaneous leg ulcers, and telangiectasia. Most of these diseases and features are present in from 40-90% of WS patients. Diagnosis of WS relies mainly upon the appearance of a certain number of these diseases and features. One biochemical test, excessive excretion of hyaluronic acid in urine, may also be used to assist diagnosis.
In addition to the noted signs and symptoms of aging, Werner Syndrome mimics normal aging as evidenced by the replicative potential of fibroblasts isolated from WS subjects. Replication potential of fibroblasts is reduced in these patients compared to fibroblasts isolated from age-matched controls, and is comparable to the replicative potential of fibroblasts taken from elderly subjects. Moreover, an increased mutation rate has been described in WS patients. Such abnormality is manifest as chromosomal instability, such as inversions, reciprocal translocations, deletions, and pseudodiploidy, and as increased mutation rate at the hypoxanthine phosphoribosyl transferase (HPRT) gene.
Werner Syndrome has been recognized as an autosomal recessive disorder. Goto et al. (Goto et al., Nature 355:735-738, 1992) mapped the WS gene onto the short arm of chromosome 8, using 21 affected Japanese families. The gene is located between marker D8S87 and ankyrin (ANK1). More recently, more refined mapping has pinpointed the WS gene to a region between marker D8S131 and D8S87, an 8.3 cM interval. Identification of the gene and gene product should add considerably to understanding the basis of Werner Syndrome and enable biochemical and genetic approaches to diagnosis and treatment.
The present invention provides a novel, previously unidentified gene for Werner Syndrome and compositions for diagnosis and treatment of WS, and further provides other related advantages.
SUMMARY OF THE INVENTION
Briefly stated, the present invention provides isolated nucleic acid molecules encoding the WRN gene, as well as portions thereof, representative of which are provided in the Figures. The protein which is encoded by the WRN gene is referred to hereinafter as the "WRN protein". Within other embodiments, nucleic acid molecules are provided which encode a mutant WRN gene product that increases the probability of Werner's Syndrome (in a statistically significant manner). Representative illustrations of such mutants are provided in Example 3.
Within other aspects of the present invention, isolated nucleic acid molecules are provided, selected from the group consisting of (a) an isolated nucleic acid molecule as set forth in the Figures, or complementary sequence thereof, (b) an isolated nucleic acid molecule that specifically hybridizes to the nucleic acid molecule of (a) under conditions of high stringency, and (c) an isolated nucleic acid that encodes a WRN gene product (WRN protein). As utilized herein, it should be understood that a nucleic acid molecule hybridizes "specifically" to an WRN gene (or related sequence) if it hybridizes detectably to such a sequence, but does not significantly or detectably hybridize to the Bloom's Syndrome gene (Ellis et al., Cell 83:655-666, 1995).
Within other aspects, expression vectors are provided comprising a promoter operably linked to one of the nucleic acid molecule described above. Representative examples of suitable promoters include tissue-specific promoters, as well as promoters such as the CMV I-E promoter, SV40 early promoter and MuLV LTR. Within related aspects, viral vectors are provided that are capable of directing the expression of a nucleic acid molecule as described above. Representative examples of such viral vectors include herpes simplex viral vectors, adenoviral vectors, adenovirus-associated viral vectors and retroviral vectors. Also provided are host cells (e.g., human, dog, monkey, rat or mouse cells) which carry the above-described vectors.
Within other aspects of the present invention, isolated proteins or polypeptides are provided comprising a WRN gene product, as well as peptides of greater than 12, 13 or 20 amino acids. Within another embodiment, the protein is a mutant WRN gene product that increases the probability of Werner's Syndrome.
Within yet another aspect of the present invention methods of treating or preventing Werner's Syndrome are provided as well as for related diseases which are discussed in more detail below), comprising the step of administering to a patient a vector containing or expressing a nucleic acid molecule as described above, thereby reducing the likelihood or delaying the onset of Werner's Syndrome (or the related disease) in the patient. Within a related aspect, methods of treating or preventing Werner's Syndrome (and related diseases) are provided, comprising the step of administering to a patient a protein as described above, thereby reducing the likelihood or delaying the onset of Werner's Syndrome (or a related disease) in the patient. Within certain embodiments, the above methods may be accomplished by in vivo administration.
Also provided by the present invention are pharmaceutical compositions comprising a nucleic acid molecule, vector, host cell, protein, or antibody as described above, along with a pharmaceutically acceptable carrier or diluent.
Within other aspects of the present invention, antibodies are provided which specifically bind to an WRN protein or to unique peptides derived therefrom. As utilized herein, it should be understood that an antibody is specific for an WRN protein (or peptide) if it binds detectably, and with a K.sub.d of 10.sup.-7 M or less (e.g., 10.sup.-8 M, 10.sup.-9 M, etc.), but does not bind detectably (or with an affinity of greater than 10.sup.-7 M, (e.g., 10.sup.-6 M, 10.sup.-5 M, etc.) to an unrelated helicase (e.g., the Bloom's syndrome gene supra). Also provided are hybridomas which are capable of producing such antibodies.
Within other aspects of the present invention, nucleic acid probes are provided which are capable of specifically hybridizing (as defined below) to an WRN gene under conditions of high stringency. Within one related aspect, such probes comprise at least a portion of the nucleotide sequence shown in the Figures, or its complementary sequence, the probe being capable of specifically hybridizing to a mutant WRN gene under conditions of high stringency. Representative probes of the present invention are generally at least 12 nucleotide bases in length, although they may be 14, 16, 18 bases or longer. Also provided are primer pairs capable of specifically amplifying all or a portion of any of the nucleic acid molecules disclosed herein.
Within other aspects of the invention, methods are provided for diagnosing a patient having an increased likelihood of contracting Werner's Syndrome (or a related disease), comprising the steps of (a) obtaining from a patient a biological sample containing nucleic acid, (b) incubating the nucleic acid with a probe which is capable of specifically hybridizing to a mutant WRN gene under conditions and for time sufficient to allow hybridization to occur, and (c) detecting the presence of hybridized probe, and thereby determining that said patient has an increased likelihood of contracting Werner's Syndrome (or a related disease). Within another aspect, methods are provided comprising the steps of (a) obtaining from a patient a biological sample containing nucleic acid, (b) amplifying a selected nucleic acid sequence associated with a mutant WRN gene, and (c) detecting the presence of an amplified nucleic acid sequence, and thereby determining that the patient has an increased likelihood of contracting Werner's Syndrome (or a related disease). Suitable biological samples include nucleated cells obtained from the peripheral blood, from buccal swabs, or brain tissue.
Within another aspect, peptide vaccines are provided which comprise a portion of a mutant WRN gene product containing a mutation, in combination with a pharmaceutically acceptable carrier or diluent.
Within yet another aspect, transgenic animals are provided whose germ cells and somatic cells contain a WRN gene (or lack thereof, i.e., a "knockout") which is operably linked to a promoter effective for the expression of the gene, the gene being introduced into the animal, or an ancestor of the animal, at an embryonic stage. Within one embodiment, the animal is a mouse, rat or dog. Within other embodiments, the WRN gene is expressed from a vector as described above. Within yet another embodiment, the WRN gene encodes a mutant WRN gene product.
These and other aspects of the present invention will become evident upon reference to the following detailed description and attached drawings. In addition, various references are set forth herein which describe in more detail certain procedures or compositions (e.g., plasmids, etc.), and are therefore incorporated by reference in their entirety.

BRIEF DESCRIPTION OF THE DRAWINGS AND SEQUENCE LISTING
FIG. 1 is a genetic and physical map of the WRN region. The genetic map (A) of the region is sex-equal with distances given in cM. The polymorphic loci used (B) are di-nucleotide and tri-nucleotide repeat STRP loci. The physical map present (C) has approximate distances determined from sizes of over-lapping non-chimeric YACs, and from genomic DNA sequence from overlapping P1 clones 2233, 2253, 3833, 2236, and 3101. Marker order was determined from the sequence-tagged site (STS) content of YACs, P1 clones, and cosmid clones and from genomic DNA sequence from P1 clones. The YACs presented (D) represent the minimal tiling and are the YACs used for cDNA selection experiments. The P1 and cosmid clones needed for the minimum tiling path are shown (E). Clones shown are P1 clones except for 8C11, which is a cosmid clone. Clone order was established by STS content.
FIGS. 2A and 2B are the DNA (SEQ ID No. 70) and predicted amino acid (SEQ ID No. 71) sequences of the WRN gene transcript. The one-letter amino acid code is used in FIG. 2B.
FIGS. 3A-3C are the DNA and predicted amino acid sequence of an alternate WRN gene transcript (SEQ ID Nos. 72 and 73).
FIGS. 4A-4G are an alignment of the WRN gene product (SEQ ID No. 74) with known helicases from S. pombe (SEQ ID No. 76), E. coli (SEQ ID No. 75), human (SEQ ID No. 77) and the Bloom's Syndrome gene "BLM" (SEQ ID No. 78).
FIGS. 5A-5U are the genomic DNA sequence of the region containing a WRN gene (SEQ ID No. 79).
FIG. 6 presents a cDNA sequence of the mouse WRN gene (SEQ ID Nos. 205 and 206).
FIG. 7 is a genomic DNA sequence of the mouse WRN gene (SEQ ID Nos. 207-209).
FIGS. 8A-D is a diagram of the WRN gene product with location of mutations. A, WRN cDNA. Numbering across the top refers to the cDNA sequence as numbered in GenBank L76937. B, Predicted WRN gene product. The helicase domain is designated as "HD", motifs from I to VI are indicated. C, Location of mutation. Numbering across the bottom refer to the mutations. *: nonsense mutation. : frame shift mutation caused by a single base deletion. Gray lines: frame shift mutations causing deletion of exon(s). D, Predicted proteins. Lines represent the different predicted truncated proteins produced from mutations in the WRN gene.
FIGS. 9A, 9B, and 9C are photomeceographs showing localization of the WRN gene product by fluorescent antibody staining (panel A), nuclei (panel B), and the size of cells (panel C) expressing the WRN gene.
FIG. 10 shows the alignment of the mouse and human WRN gene products.

DETAILED DESCRIPTION OF THE INVENTION
Definitions
Prior to setting forth the invention in detail, it may be helpful to an understanding thereof to set forth definitions of certain terms and to list and to define the abbreviations that will be used hereinafter.
"Genetic marker" is any segment of a chromosome that is distinguishably unique in the genome, and polymorphic in the population so as to provide information about the inheritance of linked DNA sequences, genes and/or other markers.
"Vector" refers to an assembly which is capable of directing the expression of a WRN gene, as well as any additional sequence(s) or gene(s) of interest. The vector must include transcriptional promoter elements which are operably linked to the genes of interest. The vector may be composed of either deoxyribonucleic acids ("DNA"), ribonucleic acids ("RNA"), or a combination of the two (e.g., a DNA-RNA chimeric). Optionally, the vector may include a polyadenylation sequence, one or more restriction sites, as well as one or more selectable markers such as neomycin phosphotransferase or hygromycin phosphotransferase. Additionally, depending on the host cell chosen and the vector employed, other genetic elements such as an origin of replication, additional nucleic acid restriction sites, enhancers, sequences conferring inducibility of transcription, and selectable markers, may also be incorporated into the vectors described herein.
Abbreviations: YAC, yeast artificial chromosome; EST, expressed sequence tag; PCR, polymerase chain reaction; RT-PCR, PCR process in which RNA is first transcribed into DNA at the first step using reverse transcriptase (RT); cDNA, any DNA made by copying an RNA sequence into DNA form.
As noted above, the present invention provides methods and compositions for the detection and treatment of Werner's Syndrome, as well as related diseases. These methods and compositions include a family of Werner's Syndrome-related genes, and the proteins encoded thereby, that have been implicated in the onset of Werner's Syndrome. These genes and proteins, including genetic markers, nucleic acid sequences and clones, are also useful in the creation of in vitro and animal models and screening tests useful for the study of Werner's Syndrome, including the possible identification of other genes implicated in Werner's Syndrome. The present invention also provides vector constructs, genetic markers, nucleic acid sequences, clones, diagnostic tests and compositions and methods for the identification of individuals likely to suffer from Werner's Syndrome.
Genes and Gene Products Related to Werner'S Syndrome
The present invention provides isolated nucleic acid molecules comprising a portion of the gene which is implicated in the onset of WS. Briefly, as can be seen from FIG. 4, this gene encodes a protein that is similar in amino acid sequence to several known ATP-dependent DNA helicases (enzymes that unwind the DNA duplex). It is less similar to known RNA-DNA helicases. Helicases are involved in the replication of DNA, often binding the replication origin, and/or the replication complex. In addition, the single stranded DNA that is involved in recombination can be generated by DNA helicases.
Although various aspects of the WRN gene (or portions thereof) are shown in the Figures, it should be understood that within the context of the present invention, reference to one or more of these genes includes derivatives of the genes that are substantially similar to the genes (and, where appropriate, the proteins (including peptides and polypeptides) that are encoded by the genes and their derivatives). As used herein, a nucleotide sequence is deemed to be "substantially similar" if: (a) the nucleotide sequence is derived from the coding region of the described genes and includes, for example, portions of the sequence or allelic variations of the sequences discussed above, or alternatively, encodes a helicase-like activity (Bjornson et al., Biochem. 3307:14306-14316, 1994); (b) the nucleotide sequence is capable of hybridization to nucleotide sequences of the present invention under high or very high stringency (see Sambrook et al., Molecular Cloning: A laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, NY, 1989); or (c) the DNA sequences are degenerate as a result of the genetic code to the DNA sequences defined in (a) or (b). Further, the nucleic acid molecule disclosed herein includes both complementary and non-complementary sequences, provided the sequences otherwise meet the criteria set forth herein. Within the context of the present invention, high stringency means standard hybridization conditions (e.g., 5.times.SSPE, 0.5% SDS at 65.degree. C., or the equivalent) while very high stringency means conditions of hybridization such that the nucleotide sequence is able to selectively hybridize to a single allele of the WS-related gene.
The WRN gene may be isolated from genomic DNA or cDNA. Genomic DNA libraries constructed in chromosomal vectors, such as YACs (yeast artificial chromosomes), bacteriophage vectors, such as .lambda.EMBL3, .lambda.gt10, cosmids, or plasmids are suitable for use. cDNA libraries constructed in bacteriophage vectors, plasmids, or others, are suitable for screening. Such libraries may be constructed using methods and techniques known in the art (see Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, 1989) or purchased from commercial sources (e.g., Clontech, Palo Alto, Calif.). Within one embodiment, the WRN gene is isolated by PCR performed on genomic DNA, cDNA or DNA from libraries, or is isolated by probe hybridization of genomic DNA or cDNA libraries. Primers for PCR and probes for hybridization screening may be designed based on the DNA sequence of WRN presented herein. The DNA sequence of a portion of the WRN gene and the entire coding sequence is presented in the Figures. Primers for PCR should be derived from sequences in the 5' and 3' untranslated region in order to isolate a full-length cDNA. The primers should not have self-complementary sequences nor have complementary sequences at their 3' end (to prevent primer-dimer formation). Preferably, the primers have a GC content of about 50% and contain restriction sites. The primers are annealed to cDNA and sufficient cycles of PCR are performed to yield a product readily visualized by gel electrophoresis and staining. The amplified fragment is purified and inserted into a vector, such as .lambda.gt10 or pBS(M13+), and propagated. An oligonucleotide hybridization probe suitable for screening genomic or cDNA libraries may be designed based on the sequence provided herein. Preferably, the oligonucleotide is 20-30 bases long. Such an oligonucleotide may be synthesized by automated synthesis. The oligonucleotide may be conveniently labeled at the 5' end with a reporter molecule, such as a radionuclide, (e.g., .sup.32 P) or biotin. The library is plated as colonies or phage, depending upon the vector, and the recombinant DNA is transferred to nylon or nitrocellulose membranes. Following denaturation, neutralization, and fixation of the DNA to the membrane, the membranes are hybridized with the labeled probe. The membranes are washed and the reporter molecule detected. The hybridizing colonies or phage are isolated and propagated. Candidate clones or PCR amplified fragments may be verified as containing WRN DNA by any of various means. For example, the candidate clones may be hybridized with a second, nonoverlapping probe or subjected to DNA sequence analysis. In these ways, clones containing WRN gene, which are suitable for use in the present invention are isolated.
The structure of the proteins encoded by the nucleic and molecules described herein may be predicted from the primary translation products using the hydrophobicity plot function of, for example, P/C Gene, Lasergen System, DNA STAR, Madison, Wis., or according to the methods described by Kyte and Doolittle (J. Mol. Biol. 157:105-132, 1982).
WRN proteins of the present invention may be prepared in the form of acidic or basic salts, or in neutral form. In addition, individual amino acid residues may be modified by oxidation or reduction. Furthermore, various substitutions, deletions, or additions may be made to the amino acid or nucleic acid sequences, the net effect of which is to retain or further enhance or decrease the biological activity of the mutant or wild-type protein. Moreover, due to degeneracy in the genetic code, for example, there may be considerable variation in nucleotide sequences encoding the same amino acid sequence.
Other derivatives of the WRN proteins disclosed herein include conjugates of the proteins along with other proteins or polypeptides. This may be accomplished, for example, by the synthesis of N-terminal or C-terminal fusion proteins which may be added to facilitate purification or identification of WRN proteins (see U.S. Pat. No. 4,851,341; see also, Hopp et al., Bio/Technology 6:1204, 1988.) Alternatively, fusion proteins such as WRN protein-.beta.-galactosidase or WRN protein-luciferase may be constructed in order to assist in the identification, expression, and analysis of WRN proteins.
WRN proteins of the present invention may be constructed using a wide variety of techniques described herein. Further, mutations may be introduced at particular loci by synthesizing oligonucleotides containing a mutant sequence, flanked by restriction sites enabling ligation to fragments of the native sequence. Following ligation, the resulting reconstructed sequence encodes a derivative having the desired amino acid insertion, substitution, or deletion.
Alternatively, oligonucleotide-directed site-specific (or segment specific) mutagenesis procedures may be employed to provide an altered gene having particular codons altered according to the substitution, deletion, or insertion required. Exemplary methods of making the alterations set forth above are disclosed by Walder et al. (Gene 42:133, 1986); Bauer et al. (Gene 37:73, 1985); Craik (BioTechniques, January 1985, 12-19); Smith et al. (Genetic Engineering: Principles and Methods, Plenum Press, 1981); and Sambrook et al. (supra). Deletion or truncation derivatives of WRN proteins (e.g., a soluble extracellular portion) may also be constructed by utilizing convenient restriction endonuclease sites adjacent to the desired deletion. Subsequent to restriction, overhangs may be filled in, and the DNA religated. Exemplary methods of making the alterations set forth above are disclosed by Sambrook et al. (Molecular Cloning: A Laboratory Manual, 2d Ed., Cold Spring Harbor Laboratory Press, 1989).
Mutations of the present invention preferably preserve the reading frame of the coding sequences. Furthermore, the mutations will preferably not create complementary regions that could hybridize to produce secondary mRNA structures, such as loops or hairpins, that would adversely affect translation of the mRNA. Although a mutation site may be predetermined, it is not necessary that the nature of the mutation per se be predetermined. For example, in order to select for optimum characteristics of mutants at a given site, random mutagenesis may be conducted at the target codon and the expressed mutants screened for indicative biological activity. Alternatively, mutations may be introduced at particular loci by synthesizing oligonucleotides containing a mutant sequence, flanked by restriction sites enabling ligation to fragments of the native sequence. Following ligation, the resulting reconstructed sequence encodes a derivative having the desired amino acid insertion, substitution, or deletion.
WRN proteins may also be constructed utilizing techniques of PCR mutagenesis, chemical mutagenesis (Drinkwater and Klinedinst, PNAS 83:3402-3406, 1986), by forced nucleotide misincorporation (e.g., Liao and Wise Gene 88:107-111, 1990), or by use of randomly mutagenized oligonucleotides (Horwitz et al., Genome 3:112-117, 1989).
Proteins can be isolated by, among other methods, culturing suitable host and vector systems to produce the recombinant translation products of the present invention. Supernates from such cell lines, or protein inclusions or whole cells where the protein is not excreted into the supernate, can then be treated by a variety of purification procedures in order to isolate the desired proteins. For example, the supernate may be first concentrated using commercially available protein concentration filters, such as an Amicon or Millipore Pellicon ultrafiltration unit. Following concentration, the concentrate may be applied to a suitable purification matrix such as, for example, an anti-protein antibody bound to a suitable support. Alternatively, anion or cation exchange resins may be employed in order to purify the protein. As a further alternative, one or more reverse-phase high performance liquid chromatography (RP-HPLC) steps may be employed to further purify the protein. Other methods of isolating the proteins of the present invention are well known in the skill of the art.
A protein is deemed to be "isolated" within the context of the present invention if no other (undesired) protein is detected pursuant to sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis followed by Coomassie blue staining. Within other embodiments, the desired protein can be isolated such that no other (undesired) protein is detected pursuant to SDS-PAGE analysis followed by silver staining.
Expression of a WRN Gene
The present invention also provides for the manipulation and expression of the above described genes by culturing host cells containing a vector capable of expressing the above-described genes. Such vectors or vector constructs include either synthetic or cDNA-derived nucleic acid molecules encoding WRN proteins, which are operably linked to suitable transcriptional or translational regulatory elements. Suitable regulatory elements may be derived from a variety of sources, including bacterial, fungal, viral, mammalian, insect, or plant genes. Selection of appropriate regulatory elements is dependent on the host cell chosen, and may be readily accomplished by one of ordinary skill in the art. Examples of regulatory elements include: a transcriptional promoter and enhancer or RNA polymerase binding sequence, a transcriptional terminator, and a ribosomal binding sequence, including a translation initiation signal.
Nucleic acid molecules that encode any of the WRN proteins described above may be readily expressed by a wide variety of prokaryotic and eukaryotic host cells, including bacterial, mammalian, yeast or other fungi, viral, insect, or plant cells. Methods for transforming or transfecting such cells to express foreign DNA are well known in the art (see, e.g., Itakura et al., U.S. Pat. No. 4,704,362; Hinnen et al., Proc. Natl. Acad. Sci. USA 75:1929-1933, 1978; Murray et al., U.S. Pat. No. 4,801,542; Upshall et al., U.S. Pat. No. 4,935,349; Hagen et al., U.S. Pat. No. 4,784,950; Axel et al., U.S. Pat. No. 4,399,216; Goeddel et al., U.S. Pat. No. 4,766,075; and Sambrook et al. Molecular Cloning: A Laboratory Manual, 2nd edition, Cold Spring Harbor Laboratory Press, 1989; for plant cells see Czako and Marton, Plant Physiol. 104:1067-1071, 1994; and Paszkowski et al., Biotech. 24:387-392, 1992).
Bacterial host cells suitable for carrying out the present invention include E. coli, B. subtilis, Salmonella typhimurium, and various species within the genera Pseudomonas, Streptomyces, and Staphylococcus, as well as many other bacterial species well known to one of ordinary skill in the art. Representative examples of bacterial host cells include DH5.alpha. (Stratagene, LaJolla, Calif.).
Bacterial expression vectors preferably comprise a promoter which functions in the host cell, one or more selectable phenotypic markers, and a bacterial origin of replication. Representative promoters include the .beta.-lactamase (penicillinase) and lactose promoter system (see Chang et al., Nature 275:615, 1978), the T7 RNA polymerase promoter (Studier et al., Meth. Enzymol. 185:60-89, 1990), the lambda promoter (Elvin et al., Gene 87:123-126, 1990), the trp promoter (Nichols and Yanofsky, Meth. in Enzymology 101:155, 1983) and the tac promoter (Russell et al., Gene 20: 231, 1982). Representative selectable markers include various antibiotic resistance markers such as the kanamycin or ampicillin resistance genes. Many plasmids suitable for transforming host cells are well known in the art, including among others, pBR322 (see Bolivar et al., Gene 2:95, 1977), the pUC plasmids pUC18, pUC19, pUC118, pUC119 (see Messing, Meth. in Enzymology 101:20-77, 1983 and Vieira and Messing, Gene 19:259-268, 1982), and pNH8A, pNH16a, pNH18a, and Bluescript M13 (Stratagene, La Jolla, Calif.).
Yeast and fungi host cells suitable for carrying out the present invention include, among others, Saccharomyces pombe, Saccharomyces cerevisiae, the genera Pichia or Kluyveromyces and various species of the genus Aspergillus (McKnight et al., U.S. Pat. No. 4,935,349). Suitable expression vectors for yeast and fungi include, among others, YCp50 (ATCC No. 37419) for yeast, and the amdS cloning vector pV3 (Turnbull, Bio/Technology 7:169, 1989), YRp7 (Struhl et al., Proc. Natl. Acad. Sci. USA 76:1035-1039, 1978), YEp13 (Broach et al., Gene 8:121-133, 1979), pJDB249 and pJDB219 (Beggs, Nature 275:104-108, 1978) and derivatives thereof.
Preferred promoters for use in yeast include promoters from yeast glycolytic genes (Hitzeman et al., J. Biol. Chem. 255:12073-12080, 1980; Alber and Kawasaki, J. Mol. Appl. Genet. 1:419-434, 1982) or alcohol dehydrogenase genes (Young et al., in Genetic Engineering of Microorganisms for Chemicals, Hollaender et al. (eds.), p. 355, Plenum, New York, 1982; Ammerer, Meth. Enzymol. 101:192-201, 1983). Examples of useful promoters for fungi vectors include those derived from Aspergillus nidulans glycolytic genes, such as the adh3 promoter (McKnight et al., EMBO J. 4:2093-2099, 1985). The expression units may also include a transcriptional terminator. An example of a suitable terminator is the adh3 terminator (McKnight et al., ibid., 1985).
As with bacterial vectors, the yeast vectors will generally include a selectable marker, which may be one of any number of genes that exhibit a dominant phenotype for which a phenotypic assay exists to enable transformants to be selected. Preferred selectable markers are those that complement host cell auxotrophy, provide antibiotic resistance or enable a cell to utilize specific carbon sources, and include leu2 Broach et al., ibid.), ura3 (Botstein et al., Gene 8:17, 1979), or his3 (Struhl et al., ibid.). Another suitable selectable marker is the cat gene, which confers chloramphenicol resistance on yeast cells.
Techniques for transforming fungi are well known in the literature, and have been described, for instance, by Beggs (ibid.), Hinnen et al. (Proc. Natl. Acad. Sci. USA 75:1929-1933, 1978), Yelton et al. (Proc. Natl. Acad. Sci. USA 81:1740-1747, 1984), and Russell (Nature 301:167-169, 1983). The genotype of the host cell may contain a genetic defect that is complemented by the selectable marker present on the expression vector. Choice of a particular host and selectable marker is well within the level of ordinary skill in the art.
Protocols for the transformation of yeast are also well known to those of ordinary skill in the art. For example, transformation may be readily accomplished either by preparation of spheroplasts of yeast with DNA (see Hinnen et al., PNAS USA 75:1929, 1978) or by treatment with alkaline salts such as LiCl (see Itoh et al., J. Bacteriology 153:163, 1983). Transformation of fungi may also be carried out using polyethylene glycol as described by Cullen et al. (Bio/Technology 5:369, 1987).
Viral vectors include those which comprise a promoter that directs the expression of an isolated nucleic acid molecule that encodes an WRN protein as described above. A wide variety of promoters may be utilized within the context of the present invention; including for example, promoters such as MoMLV LTR, RSV LTR, Friend MuLV LTR, adenoviral promoter (Ohno et al., Science 265: 781-784, 1994), neomycin phosphotransferase promoter/enhancer, late parvovirus promoter (Koering et al., Hum. Gene Therap. 5:457-463, 1994), Herpes TK promoter, SV40 promoter, metallothionein IIa gene enhancer/promoter, cytomegalovirus immediate early promoter, and the cytomegalovirus immediate late promoter. Within particularly preferred embodiments of the invention, the promoter is a tissue-specific promoter (see e.g., WO 91/02805; EP 0,415,731; and WO 90/07936). Representative examples of suitable tissue specific promoters include neural specific enolase promoter, platelet derived growth factor beta promoter, bone morpho-genetic protein promoter, human alpha1-chimaerin promoter, synapsin I promoter and synapsin II promoter. In addition to the above-noted promoters, other viral-specific promoters (e.g., retroviral promoters (including those noted above, as well as others such as HIV promoters), hepatitis, herpes (e.g., EBV), and bacterial, fungal or parasitic (e.g., malarial)-specific promoters may be utilized in order to target a specific cell or tissue which is infected with a virus, bacteria, fungus or parasite.
Thus, WRN proteins of the present invention may be expressed from a variety of viral vectors, including for example, herpes viral vectors (e.g., U.S. Pat. No. 5,288,641), adenoviral vectors (e.g., WO 94/26914, WO 93/9191; Kolls et al., PNAS 91(1):215-219, 1994; Kass-Eisler et al., PNAS 90(24):11498-502, 1993; Guzman et al., Circulation 88(6):2838-48, 1993; Guzman et al., Cir. Res. 73(6):1202-1207, 1993; Zabner et al., Cell 75(2)207-216, 1993; Li et al., Hum Gene Ther. 4(4):403-409, 1993; Caillaud et al., Eur. J. Neurosci. 5(10:1287-1291, 1993; Vincent et al., Nat. Genet. 5(2):130-134, 1993; Jaffe et al., Nat. Genet. 1(5):372-378, 1992; and Levrero et al, Gene 101(2):195-202, 1991), adeno-associated viral vectors (WO 95/13365; Flotte et al., PNAS 90(22):10613-10617, 1993), baculovirus vectors, parvovirus vectors (Koering et al., Hum. Gene Therap. 5:457-463, 1994), pox virus vectors (Panicali and Paoletti, PNAS 79:4927-4931, 1982; and Ozaki et al., Biochem. Biophys. Res. Comm. 193(2):653-660, 1993), and retroviruses (e.g., EP 0,415,731; WO 90/07936; WO 91/0285, WO 94/03622; WO 93/25698; WO 93/25234; U.S. Pat. No. 5,219,740; WO 93/11230; WO 93/10218. Viral vectors may likewise be constructed which contain a mixture of different elements (e.g., promoters, envelope sequences and the like) from different viruses, or non-viral sources. Within various embodiments, either the viral vector itself, or a viral particle which contains the viral vector may be utilized in the methods and compositions described below.
Mammalian cells suitable for carrying out the present invention include, among others: PC12 (ATCC No. CRL1721), 1E-115 neuroblastoma, SK-N-BE(2)C neuroblastoma, SHSY5 adrenergic neuroblastoma, NS20Y and NG108-15 murine cholinergic cell lines, or rat F2 dorsal root ganglion line, COS (e.g., ATCC No. CRL 1650 or 1651), BHK (e.g., ATCC No. CRL 6281; BHK 570 cell line (deposited with the American Type Culture Collection under accession number CRL 10314), CHO (ATCC No. CCL 61), HeLa (e.g., ATCC No. CCL 2), 293 (ATCC No. 1573; Graham et al., J. Gen. Viral. 36:59-72, 1977) and NS-1 cells. Other mammalian cell lines may be used within the present invention, including Rat Hep I (ATCC No. CRL 1600), Rat Hep II (ATCC No. CRL 1548), TCMK (ATCC No. CCL 139), Human lung (ATCC No. CCL 75.1), Human hepatoma (ATCC No. HTB-52), Hep G2 (ATCC No. HB 8065), Mouse liver (ATCC No. CCL 29.1), NCTC 1469 (ATCC No. CCL 9.1), SP2/0-Ag14 (ATCC No. 1581), HIT-T15 (ATCC No. CRL 1777), and RINm 5AHT.sub.2 B (Orskov and Nielson, FEBS 229(1):175-178, 1988).
Mammalian expression vectors for use in carrying out the present invention will include a promoter capable of directing the transcription of a cloned gene or cDNA. Preferred promoters include viral promoters and cellular promoters. Viral promoters include the cytomegalovirus immediate early promoter (Boshart et al., Cell 41:521-530, 1985), cytomegalovirus immediate late promoter, SV40 promoter (Subramani et al., Mol. Cell. Biol. 1:854-864, 1981), MMTV LTR, RSV LTR, metallothionein-1, adenovirus E1a. Cellular promoters include the mouse metallothionein-1 promoter (Palmiter et al., U.S. Pat. No. 4,579,821), a mouse V.sub.K promoter (Bergman et al., Proc. Natl. Acad. Sci. USA 81:7041-7045, 1983; Grant et al., Nucl. Acids Res. 15:5496, 1987) and a mouse V.sub.H promoter (Loh et al., Cell 33:85-93, 1983). The choice of promoter will depend, at least in part, upon the level of expression desired or the recipient cell line to be transfected.
Such expression vectors may also contain a set of RNA splice sites located downstream from the promoter and upstream from the DNA sequence encoding the peptide or protein of interest. Preferred RNA splice sites may be obtained from adenovirus and/or immunoglobulin genes. Also contained in the expression vectors is a polyadenylation signal located downstream of the coding sequence of interest. Suitable polyadenylation signals include the early or late polyadenylation signals from SV40 (Kaufman and Sharp, ibid.), the polyadenylation signal from the Adenovirus 5 E1B region and the human growth hormone gene terminator (DeNoto et al., Nuc. Acids Res. 9:3719-3730, 1981). The expression vectors may include a noncoding viral leader sequence, such as the Adenovirus 2 tripartite leader, located between the promoter and the RNA splice sites. Preferred vectors may also include enhancer sequences, such as the SV40 enhancer. Expression vectors may also include sequences encoding the adenovirus VA RNAs. Suitable expression vectors can be obtained from commercial sources (e.g., Stratagene, La Jolla, Calif.).
Vector constructs comprising cloned DNA sequences can be introduce into cultured mammalian cells by, for example, calcium phosphate-mediated transfection (Wigler et al., Cell 14:725, 1978; Corsaro and Pearson, Somatic Cell Genetics 7:603, 1981; Graham and Van der Eb, Virology 52:456, 1973), electroporation (Neumann et al., EMBO J. 1:841-845, 1982), or DEAE-dextran mediated transfection (Ausubel et al. (eds.), Current Protocols in Molecular Biology, John Wiley and Sons, Inc. NY, 1987). To identify cells that have stably integrated the cloned DNA, a selectable marker is generally introduced into the cells along with the gene or cDNA of interest. Preferred selectable markers for use in cultured mammalian cells include genes that confer resistance to drugs, such as neomycin, hygromycin, and methotrexate. The selectable marker may be an amplifiable selectable marker. Preferred amplifiable selectable markers are the DHFR gene and the neomycin resistance gene. Selectable markers are reviewed by Thilly (Mammalian Cell Technology, Butterworth Publishers, Stoneham, Mass., which is incorporated herein by reference).
Mammalian cells containing a suitable vector are allowed to grow for a period of time, typically 1-2 days, to begin expressing the DNA sequence(s) of interest. Drug selection is then applied to select for growth of cells that are expressing the selectable marker in a stable fashion. For cells that have been transfected with an amplifiable, selectable marker the drug concentration may be increased in a stepwise manner to select for increased copy number of the cloned sequences, thereby increasing expression levels. Cells expressing the introduced sequences are selected and screened for production of the protein of interest in the desired form or at the desired level. Cells that satisfy these criteria can then be cloned and scaled up for production.
Protocols for the transfection of mammalian cells are well known to those of ordinary skill in the art. Representative methods include calcium phosphate mediated transfection, electroporation, lipofection, retroviral, adenoviral and protoplast fusion-mediated transfection (see Sambrook et al., supra). Naked vector constructs can also be taken up by muscular cells or other suitable cells subsequent to injection into the muscle of a mammal (or other animals).
Numerous insect host cells known in the art can also be useful within the present invention, in light of the subject specification. For example, the use of baculoviruses as vectors for expressing heterologous DNA sequences in insect cells has been reviewed by Atkinson et al. (Pestic. Sci. 28:215-224, 1990).
Numerous plant host cells known in the art can also be useful within the present invention, in light of the subject specification. For example, the use of Agrobacterium rhizogenes as vectors for expressing genes in plant cells has been reviewed by Sinkar et al., (J. Biosci. (Bangalore) 11:47-58, 1987).
WRN proteins may be prepared by growing (typically by culturing) the host/vector systems described above, in order to express the recombinant WRN proteins. Recombinantly produced WRN proteins may be further purified as described in more detail below.
Within related aspects of the present invention, WRN proteins may be expressed in a transgenic animal whose germ cells and somatic cells contain a WRN gene which is operably linked to a promoter effective for the expression of the gene. Alternatively, in a similar manner transgenic animals may be prepared that lack the WRN gene (e.g., "knockout" mice). Such transgenics may be prepared in a variety non-human animals, including mice, rats, rabbits, sheep, dogs, goats and pigs (see Hammer et al. Nature 315:680-683, 1985, Palmiter et al. Science 222:809-814, 1983, Brinster et al. Proc. Natl. Acad. Sci. USA 82:4438-4442, 1985, Palmiter and Brinster Cell 41:343-345, 1985 and U.S. Pat. Nos. 5,175,383, 5,087,571, 4,736,866, 5,387,742, 5,347,075, 5,221,778, and 5,175,384).
Briefly, an expression vector, including a nucleic acid molecule to be expressed together with appropriately positioned expression control sequences, is introduced into pronuclei of fertilized eggs, for example, by microinjection. Integration of the injected DNA is detected by blot analysis of DNA from tissue samples. It is preferred that the introduced DNA be incorporated into the germ line of the animal so that it is passed on to the animal's progeny. Tissue-specific expression may be achieved through the use of a tissue-specific promoter, or through the use of an inducible promoter, such as the metallothionein gene promoter (Palmiter et al., 1983, ibid), which allows regulated expression of the transgene.
Vectors of the present invention may contain or express a wide variety of additional nucleic acid molecules in place of or in addition to an WRN protein as described above, either from one or several separate promoters. For example, the viral vector may express a lymphokine or lymphokine receptor, antisense or ribozyme sequence or toxins. Representative examples of lymphokines include IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, GM-CSF, G-CSF, M-CSF, alpha-interferon, beta-interferon, gamma-interferon, and tumor necrosis factors, as well as their respective receptors. Representative examples of antisense sequences include antisense sequences which block the expression of WRN protein mutants. Representative examples of toxins include: ricin, abrin, diphtheria toxin, cholera toxin, saporin, gelonin, pokeweed antiviral protein, tritin, Shigella toxin, and Pseudomonas exotoxin A.
Within other aspects of the invention, antisense oligonucleotide molecules are provided which specifically inhibit expression of mutant WRN nucleic acid sequences (see generally, Hirashima et al. in Molecular Biology of RNA: New Perspectives (M. Inouye and B. S. Dudock, eds., 1987 Academic Press, San Diego, p. 401); Oligonucleotides: Antisense Inhibitors of Gene Expression (J. S. Cohen, ed., 1989 MacMillan Press, London); Stein and Cheng, Science 261:1004-1012 (1993); WO 95/10607; U.S. Pat. No. 5,359,051; WO 92/06693; and EP-A2-612844). Briefly, such molecules are constructed such that they are complementary to, and able to form Watson-Crick base pairs with, a region of transcribed WRN mutant mRNA sequence containing an WRN mutation. The resultant double-stranded nucleic acid interferes with subsequent processing of the mRNA, thereby preventing protein synthesis.
Within other related aspects of the invention, ribozyme molecules are provided wherein an antisense oligonucleotide sequence is incorporated into a ribozyme which can specifically cleave mRNA molecules transcribed from a mutant WRN gene (see generally, Kim et al. Proc. Nat. Acad. Sci. USA 84:8788 (1987); Haseloff, et al. Nature 234:585 (1988), Cech, JAMA 260:3030 (1988); Jeffries, et al. Nucleic Acids Res. 17:1371 (1989); U.S. Pat. No. 5,093,246; U.S. Pat. No. 5,354,855; U.S. Pat. No. 5,144,019; U.S. Pat. No. 5,272,262; U.S. Pat. No. 5,254,678; and U.S. Pat. No. 4,987,071). According to this aspect of the invention, the antisense sequence which is incorporated into a ribozyme includes a sequence complementary to, and able to form Watson-Crick base pairs with, a region of the transcribed mutant WRN mRNA containing an WRN mutation. The antisense sequence thus becomes a targeting agent for delivery of catalytic ribozyme activity specifically to mutant WRN mRNA, where such catalytic activity cleaves the mRNA to render it incapable of being subsequently processed for WRN protein translation.
Host Cells
As discussed above, nucleic acid molecules which encode the WRN proteins of the present invention (or the vectors which contain and/or express related mutants) may readily be introduced into a wide variety of host cells. Representative examples of such host cells include plant cells, eukaryotic cells, and prokaryotic cells. Within preferred embodiments, the nucleic acid molecules are introduced into cells from a vertebrate or warm-blooded animal, such as a human, macaque, dog, cow, horse, pig, sheep, rat, hamster, mouse or fish cell, or any hybrid thereof.
Preferred prokaryotic host cells for use within the present invention include E. coli, Salmonella, Bacillus, Shigella, Pseudomonas, Streptomyces and other genera. Techniques for transforming these hosts and expressing foreign DNA sequences cloned therein are well known in the art (see, e.g., Maniatis et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, 1982, which is incorporated herein by reference; or Sambrook et al., supra). Vectors used for expressing cloned DNA sequences in bacterial hosts will generally contain a selectable marker, such as a gene for antibiotic resistance, and a promoter that functions in the host cell. Appropriate promoters include the trp (Nichols and Yanofsky, Meth. Enzymol. 101:155-164, 1983), lac (Casadaban et al., J. Bacteriol. 143:971-980, 1980), and phage .lambda. (Queen, J. Mol. Appl. Genet. 2:1-10, 1983) promoter systems. Plasmids useful for transforming bacteria include the pUC plasmids (Messing, Meth. Enzymol. 101:20-78, 1983; Vieira and Messing, Gene 19:259-268, 1982), pBR322 (Bolivar et al., Gene 2:95-113, 1977), pCQV2 (Queen, ibid.), and derivatives thereof. Plasmids may contain both viral and bacterial elements.
Preferred eukaryotic cells include cultured mammalian cell lines (e.g., rodent or human cell lines) and fungal cells, including species of yeast (e.g., Saccharomyces spp., particularly S. cerevisiae, Schizosaccharomyces spp., or Kluyveromyces spp.) or filamentous fungi (e.g., Aspergillus spp., Neurospora spp.). Strains of the yeast Saccharomyces cerevisiae are particularly preferred. Methods for producing recombinant proteins in a variety of prokaryotic and eukaryotic host cells are generally known in the art (see, "Gene Expression Technology," Methods in Enzymology, Vol. 185, Goeddel (ed.), Academic Press, San Diego, Calif., 1990; see also, "Guide to Yeast Genetics and Molecular Biology," Methods in Enzymology, Guthrie and Fink (eds.), Academic Press, San Diego, Calif., 1991). In general, a host cell will be selected on the basis of its ability to produce the protein of interest at a high level or its ability to carry out at least some of the processing steps necessary for the biological activity of the protein. In this way, the number of cloned DNA sequences that must be introduced into the host cell can be minimized and overall yield of biologically active protein can be maximized.
The nucleic acid molecules (or vectors) may be introduced into host cells by a wide variety of mechanisms, including for example calcium phosphate-mediated transfection (Wigler et al., Cell 14:725, 1978), lipofection; gene gun (Corsaro and Pearson, Somatic Cell Gen. 7:603, 1981; Graham and Van der Eb, Virology 52:456, 1973), electroporation (Neumann et al., EMBO J. 1:841-845, 1982), retroviral, adenoviral, protoplast fusion-mediated transfection or DEAE-dextran mediated transfection (Ausubel et al., (eds.), Current Protocols in Molecular Biology, John Wiley and Sons, Inc., NY, N.Y., 1987).
Host cells containing vector constructs of the present invention are then cultured to express a DNA molecule as described above. The cells are cultured according to standard methods in a culture medium containing nutrients required for growth of the chosen host cells. A variety of suitable media are known in the art and generally include a carbon source, a nitrogen source, essential amino acids, vitamins and minerals, as well as other components, e.g., growth factors or serum, that may be required by the particular host cells. The growth medium will generally select for cells containing the DNA construct(s) by, for example, drug selection or deficiency in an essential nutrient which is complemented by the selectable marker on the DNA construct or co-transfected with the DNA construct.
Suitable growth conditions for yeast cells, for example, include culturing in a chemically defined medium, comprising a nitrogen source, which may be a non-amino acid nitrogen source or a yeast extract, inorganic salts, vitamins and essential amino acid supplements at a temperature between 4.degree. C. and 37.degree. C., with 30.degree. C. being particularly preferred. The pH of the medium is preferably maintained at a pH greater than 2 and less than 8, more preferably pH 5-6. Methods for maintaining a stable pH include buffering and constant pH control. Preferred agents for pH control include sodium hydroxide. Preferred buffering agents include succinic acid and Bis-Tris (Sigma Chemical Co., St. Louis, Mo.). Due to the tendency of yeast host cells to hyperglycosylate heterologous proteins, it may be preferable to express the nucleic acid molecules of the present invention in yeast cells having a defect in a gene required for asparagine-linked glycosylation. Such cells are preferably grown in a medium containing an osmotic stabilizer. A preferred osmotic stabilizer is sorbitol supplemented into the medium at a concentration between 0.1 M and 1.5 M, preferably at 0.5 M or 1.0 M.
Cultured mammalian cells are generally cultured in commercially available serum-containing or serum-free media. Selection of a medium and growth conditions appropriate for the particular cell line used is well within the level of ordinary skill in the art.
Antibodies
Antibodies to the WRN proteins discussed above may readily be prepared given the disclosure provided herein. Such antibodies may, within certain embodiments, specifically recognize wild type WRN protein rather than a mutant WRN protein, mutant WRN protein rather than wild type WRN protein, or equally recognize both the mutant and wild-type forms of WRN protein. Antibodies may be used for isolation of the protein, establishing intracellular localization of the WRN protein, inhibiting activity of the protein (antagonist), or enhancing activity of the protein (agonist). Knowledge of the intracellular location of the WRN gene product may be abnormal in patients with WRN mutations, thus allowing the development of a rapid screening assay. As well, assays for small molecules that interact with the WRN gene product will be facilitated by the development of antibodies and localization studies.
Within the context of the present invention, antibodies are understood to include monoclonal antibodies, polyclonal antibodies, anti-idiotypic antibodies, antibody fragments (e.g., Fab, and F(ab').sub.2, F.sub.V variable regions, or complementarity determining regions). As discussed above, antibodies are understood to be specific against an WRN protein if it binds with a K.sub.d of greater than or equal to 10.sup.-7 M, preferably greater than of equal to 10.sup.-8 M. The affinity of a monoclonal antibody or binding partner can be readily determined by one of ordinary skill in the art (see Scatchard, Ann. N.Y. Acad. Sci. 51:660-672, 1949).
Briefly, polyclonal antibodies may be readily generated by one of ordinary skill in the art from a variety of warm-blooded animals such as horses, cows, various fowl, rabbits, mice, or rats. Typically, an WRN protein or unique peptide thereof of 13-20 amino acids (preferably conjugated to keyhole limpet hemocyanin by cross-linking with glutaraldehyde) is utilized to immunize the animal through intraperitoneal, intramuscular, intraocular, or subcutaneous injections, an adjuvant such as Freund's complete or incomplete adjuvant. Merely as an example, a peptide corresponding to residues 1375 through 1387 of the WRN polypeptide sequence is used to raise a rabbit polyclonal antiserum. Following several booster immunizations, samples of serum are collected and tested for reactivity to the WRN protein or peptide. Particularly preferred polyclonal antisera will give a signal on one of these assays that is at least three times greater than background. Once the titer of the animal has reached a plateau in terms of its reactivity to the protein, larger quantities of antisera may be readily obtained either by weekly bleedings, or by exsanguinating the animal.
Monoclonal antibodies may also be readily generated using conventional techniques (see U.S. Pat. Nos. RE 32,011, 4,902,614, 4,543,439, and 4,411,993 which are incorporated herein by reference; see also Monoclonal Antibodies, Hybridomas: A New Dimension in Biological Analyses, Plenum Press, Kennett, McKearn, and Bechtol (eds.), 1980, and Antibodies: A Laboratory Manual, Harlow and Lane (eds.), Cold Spring Harbor Laboratory Press, 1988, which are also incorporated herein by reference).
Briefly, within one embodiment a subject animal such as a rat or mouse is injected with an WRN protein or portion thereof as described above. The protein may be admixed with an adjuvant such as Freund's complete or incomplete adjuvant in order to increase the resultant immune response. Between one and three weeks after the initial immunization the animal may be reimmunized with another booster immunization, and tested for reactivity to the protein utilizing assays described above. Once the animal has reached a plateau in its reactivity to the injected protein, it is sacrificed, and organs which contain large numbers of B cells such as the spleen and lymph nodes are harvested.
Cells which are obtained from the immunized animal may be immortalized by transfection with a virus such as the Epstein-Barr virus (EBV) (see Glasky and Reading, Hybridoma 8(4):377-389, 1989). Alternatively, within a preferred embodiment, the harvested spleen and/or lymph node cell suspensions are fused with a suitable myeloma cell in order to create a "hybridoma" which secretes monoclonal antibody. Suitable myeloma lines include, for example, NS-1 (ATCC No. TIB 18), and P3X63-Ag 8.653 (ATCC No. CRL 1580).
Following the fusion, the cells may be placed into culture plates containing a suitable medium, such as RPMI 1640, or DMEM (Dulbecco's Modified Eagles Medium) (JRH Biosciences, Lenexa, Kans.), as well as additional ingredients, such as fetal bovine serum (FBS, i.e., from Hyclone, Logan, Utah, or JRH Biosciences). Additionally, the medium should contain a reagent which selectively allows for the growth of fused spleen and myeloma cells such as HAT (hypoxanthine, aminopterin, and thymidine) (Sigma Chemical Co., St. Louis, Mo.). After about seven days, the resulting fused cells or hybridomas may be screened in order to determine the presence of antibodies which are reactive against an WRN protein. A wide variety of assays may be utilized to determine the presence of antibodies which are reactive against the proteins of the present invention, including for example countercurrent immunoelectrophoresis, radioimmunoassays, radioimmunoprecipitations, enzyme-linked immuno-sorbent assays (ELISA), dot blot assays, western blots, immunoprecipitation, Inhibition or Competition Assays, and sandwich assays (see U.S. Pat. Nos. 4,376,110 and 4,486,530; see also Antibodies: A Laboratory Manual, Harlow and Lane (eds.), Cold Spring Harbor Laboratory Press, 1988). Following several clonal dilutions and reassays, a hybridoma producing antibodies reactive against the WRN protein may be isolated.
Other techniques may also be utilized to construct monoclonal antibodies (see William D. Huse et al., "Generation of a Large Combinational Library of the Immunoglobulin Repertoire in Phage Lambda," Science 246:1275-1281, December 1989; see also L. Sastry et al., "Cloning of the Immunological Repertoire in Escherichia coli for Generation of Monoclonal Catalytic Antibodies: Construction of a Heavy Chain Variable Region-Specific cDNA Library," Proc. Natl. Acad. Sci. USA 86:5728-5732, August 1989; see also Michelle Alting-Mees et al., "Monoclonal Antibody Expression Libraries: A Rapid Alternative to Hybridomas," Strategies in Molecular Biology 3:1-9, January 1990; These references describe a commercial system available from Stratacyte, La Jolla, Calif., which enables the production of antibodies through recombinant techniques). Briefly, mRNA is isolated from a B cell population, and utilized to create heavy and light chain immunoglobulin cDNA expression libraries in the .lambda. ImmunoZap(H) and .lambda.ImmunoZap(L) vectors. These vectors may be screened individually or co-expressed to form Fab fragments or antibodies (see Huse et al., supra; see also Sastry et al., supra). Positive plaques may subsequently be converted to a non-lytic plasmid which allows high level expression of monoclonal antibody fragments from E. coli.
Similarly, portions or fragments, such as Fab and Fv fragments, of antibodies may also be constructed utilizing conventional enzymatic digestion or recombinant DNA techniques to incorporate the variable regions of a gene which encodes a specifically binding antibody. Within one embodiment, the genes which encode the variable region from a hybridoma producing a monoclonal antibody of interest are amplified using nucleotide primers for the variable region. These primers may be synthesized by one of ordinary skill in the art, or may be purchased from commercially available sources. Stratacyte (La Jolla, Calif.) sells primers for mouse and human variable regions including, among others, primers for V.sub.Ha, V.sub.Hb, V.sub.Hc, V.sub.Hd, C.sub.H1, V.sub.L and C.sub.L regions. These primers may be utilized to amplify heavy or light chain variable regions, which may then be inserted into vectors such as ImmunoZAP.TM. H or ImmunoZAP.TM. L (Stratacyte), respectively. These vectors may then be introduced into E. coli, yeast, or mammalian-based systems for expression. Utilizing these techniques, large amounts of a single-chain protein containing a fusion of the V.sub.H and V.sub.L domains may be produced (see Bird et al., Science 242:423-426, 1988). In addition, such techniques may be utilized to change a "murine" antibody to a "human" antibody, without altering the binding specificity of the antibody.
Once suitable antibodies have been obtained, they may be isolated or purified by many techniques well known to those of ordinary skill in the art (see Antibodies: A Laboratory Manual, Harlow and Lane (eds.), Cold Spring Harbor Laboratory Press, 1988). Suitable techniques include peptide or protein affinity columns, HPLC or RP-HPLC, purification on protein A or protein G columns, or any combination of these techniques.
Assays
Assays useful within the context of the present invention include those assays for detecting agonists or antagonists of WRN protein activity. Other assays are useful for the screening of peptide or organic molecule libraries. Still other assays are useful for the identification and/or isolation of nucleic acid molecules and/or peptides within the present invention, the identification of proteins that interact or bind the WRN protein, for diagnosis of a patient with an increased likelihood of contracting Werner's Syndrome, or for diagnosis of a patient with susceptibility to or manifestation of a WRN-related disease.
Nucleic Acid Based Diagnostic Tests
Briefly, another aspect of the present invention provides probes and primers for detecting the WRN genes and/or mutants thereof. In one embodiment of this aspect, probes are provided that are capable of specifically hybridizing to DNA or RNA of the WRN genes. For purposes of the present invention, probes are "capable of hybridizing" to DNA or RNA of the WRN gene if they hybridize to an WRN gene under conditions of either high or moderate stringency (see Sambrook et al., supra) but not significantly or detectably to the an unrelated helicase gene such as the Bloom's Syndrome gene (Ellis et al., Cell 83:655-666, 1995). Preferably, the probe hybridizes to suitable nucleotide sequences under high stringency conditions, such as hybridization in 5.times.SSPE, 1.times.Denhardt's solution, 0.1% SDS at 65.degree. C., and at least one wash to remove unhybridized probe in the presence of 0.2.times.SSC, 1.times.Denhardt's solution, 0.1% SDS at 65.degree. C. Except sa otherwise provided herein, probe sequences are designed to allow hybridization to WRN genes, but not to DNA or RNA sequences from other genes. The probes are used, for example, to hybridize to nucleic acid that is present in a biological sample isolated from a patient. The hybridized probe is then detected, thereby indicating the presence of the desired cellular nucleic acid. Preferably, the cellular nucleic acid is subjected to an amplification procedure, such as PCR, prior to hybridization. Alternatively, the WRN gene may be amplified and the amplified product subjected to DNA sequencing. Mutants of WRN may be detected by DNA sequence analysis or hybridization with allele-specific oligonucleotide probes under conditions and for time sufficient to allow hybridization to the specific allele. Typically, the hybridization buffer and was will contain tetramethyl ammonium chloride or the like (see Sambrook et al., supra).
Nucleic acid probes of the present invention may be composed of either deoxyribonucleic acids (DNA), ribonucleic acids (RNA), nucleic acid analogues (e.g., peptide nucleic acids), or any combination thereof, and may be as few as about 12 nucleotides in length, usually about 14 to 18 nucleotides in length, and possibly as large as the entire sequence of a WRN gene. Selection of probe size is somewhat dependent upon the use of the probe, and is within the skill of the art.
Suitable probes can be constructed and labeled using techniques that are well known in the art. Shorter probes of, for example, 12 bases can be generated synthetically and labeled with .sup.32 P using T.sub.4 polynucleotide kinase. Longer probes of about 75 bases to less than 1.5 kb are preferably generated by, for example, PCR amplification in the presence of labeled precursors such as [.alpha.-.sup.32 P]dCTP, digoxigenin-dUTP, or biotin-dATP. Probes of more than 1.5 kb are generally most easily amplified by transfecting a cell with a plasmid containing the relevant probe, growing the transfected cell into large quantities, and purifying the relevant sequence from the transfected cells. (See Sambrook et al., supra.)
Probes can be labeled by a variety of markers, including for example, radioactive markers, fluorescent markers, enzymatic markers, and chromogenic markers. The use of .sup.32 P is particularly preferred for marking or labeling a particular probe.
It is a feature of this aspect of the invention that the probes can be utilized to detect the presence of WRN mRNA or DNA within a sample. However, if the relevant sample is present in only a limited number, then it may be beneficial to amplify the relevant sequence so that it may be more readily detected or obtained.
A variety of methods may be utilized in order to amplify a selected sequence, including, for example, RNA amplification (see Lizardi et al., Bio/Technology 6:1197-1202, 1988; Kramer et al., Nature 339:401-402, 1989; Lomeli et al., Clinical Chem. 35(9):1826-1831, 1989; U.S. Pat. No. 4,786,600), and DNA amplification utilizing LCR or polymerase chain reaction ("PCR") (see, U.S. Pat. Nos. 4,683,195, 4,683,202, and 4,800,159) (see also U.S. Pat. Nos. 4,876,187 and 5,011,769, which describe an alternative detection/amplification system comprising the use of scissile linkages), or other nucleic acid amplification procedures that are well within the level of ordinary skill in the art. With respect to PCR, for example, the method may be modified as known in the art. Transcriptional enhancement of PCR may be accomplished by incorporation of bacteriophage T7 RNA polymerase promoter sequences in one of the primary oligonucleotides, and immunoenzymatic detection of the products from the enhanced emitter may be effected using anti-RNA:DNA antibodies (Blais, Appl. Environ. Microbiol. 60:348-352, 1994). PCR may also be used in combination with reverse dot-blot hybridization (Iida et al., FEMS Microbiol. Lett. 114:167-172, 1993). PCR products may be quantitatively analyzed by incorporation of dUTP (Duplaa et al., Anal. Biochem. 212:229-236, 1993), and samples may be filter sampled for PCR-gene probe detection (Bej et al., Appl. Environ. Microbiol. 57:3529-3534, 1991).
Within a particularly preferred embodiment, PCR amplification is utilized to detect the WRN DNA. Briefly, as described in greater detail below, a DNA sample is denatured at 95.degree. C. in order to generate single-stranded DNA. The DNA sample may be a cDNA generated from RNA. Specific primers are then annealed to the single-stranded DNA at 37.degree. C. to 70.degree. C., depending on the proportion of AT/GC in the primers. The primers are extended at 72.degree. C. with Taq DNA polymerase or other thermostable DNA polymerase in order to generate the opposite strand to the template. These steps constitute one cycle, which may be repeated in order to amplify the selected sequence. For greater specificity, nested PCR may be performed. In nested PCR, a second amplification is performed using a second set of primers derived from sequences within the first amplified product. The entire coding region of WRN may be amplified from cDNA using three sets of primers to generate fragment lengths that are a convenient size for determining their sequence. In a preferred embodiment, nested PCR is performed.
Within an alternative preferred embodiment, LCR amplification is utilized for amplification. LCR primers are synthesized such that the 5' base of the upstream primer is capable of hybridizing to a unique base pair in a desired gene to specifically detect an WRN gene.
Within another preferred embodiment, the probes are used in an automated, non-isotopic strategy wherein target nucleic acid sequences are amplified by PCR, and then desired products are determined by a colorimetric oligonucleotide ligation assay (OLA) (Nickerson et al., Proc. Natl. Acad. Sci. USA 81:8923-8927, 1990).
Primers for the amplification of a selected sequence should be selected from sequences that are highly specific to WRN (and not, e.g., the Bloom's Syndrome gene, supra) and form stable duplexes with the target sequence. The primers should also be non-complementary, especially at the 3'0 end, should not form dimers with themselves or other primers, and should not form secondary structures or duplexes with other regions of DNA. In general, primers of about 18 to 20 nucleotides are preferred, and can be easily synthesized using techniques well known in the art. PCR products, and other nucleic acid amplification products, may be quantitated using techniques known in the art (Duplaa et al., Anal. Biochem. 212:229-236, 1993; Higuchi et al., Bio/Technology 11:1026-1030).
Within one embodiment of the invention, nucleic acid diagnostics may be developed which are capable of detecting the presence of Werner's Syndrome, or of various related diseases that may be caused by Werner's Syndrome. Briefly, severe mutations in the WRN gene may lead to Werner's Syndrome, as well as a host of related diseases, including for example, increased frequency of some benign and malignant neoplasms (especially sarcomas), cataracts, cardiovascular disease, osteoporosis, type I or type II diabetes, cataracts, sclerodoma-like skin changes and hyperkeratosis. Less severe mutations of the gene may lead to the onset of the same set of diseases, but at an older age. In addition, many of the related diseases may be associated with mutations in the WRN gene. For example, diabetes and osteoporosis are often associated with aging. Aging population and individuals with these (or other) diseases are screened for mutations in WRN. Any of the assays described herein may be used. RT-PCR is especially preferred in conjunction with DNA sequence determination. To correlate a mutation or polymorphism with disease, sibling pairs in which one sibling has disease are preferred subjects. Once a mutation is identified, other convenient screening assays may be used to assay particular nucleotide changes.
Since the sequences of the two copies of the gene from non-Werner's affected individuals can be correlated with the medical histories of these patients to define these correspondences, these alleles can therefore be used as diagnostics for susceptibilities to these diseases, once the relationship is defined. Certain non-null forms of the gene, for example, in either the homozygous or heterozygous state may significantly affect the propensity for the carriers to develop, for example, cancer. These propensities can be ascertained by examining the sequences of the gene (both copies) in a statistically significant sample of cancer patients. Other diseases (see above) can be similarly examined for significant correlations with certain alleles. To detect such a causal relationship one can use a chi-squared test, or other statistical test, to examine the significance of any correlation between the appropriate genotypes and the disease state as recorded in the medical records, using standard good practices of medical epidemiology. The sequences that define each of the alleles are then valuable diagnostic indicators for an increased susceptibility to the disease. Thus, from the nucleic acid sequences provided herein, a wide variety of Werner's Syndrome-related diseases may be readily detected.
Another cellular phenotype of the cells from Werner's patients is the increased frequency of deletion mutation in these cells. Clearly, the defective helicase in these cells leads to a specific mutator phenotype, while not rendering the cells hypersensitive to a variety of chemical or physical mutagens that damage DNA, like ionizing radiation. Disease states, or sensitivities that result from an elevated deletion frequency can therefore be controlled, in part, by alterations of the Werner's gene, and some alleles may therefore be diagnostic of this class of medical conditions.
Assays for Agonists and Antagonists
An agonist or antagonist of the WRN gene product comprising a protein, peptide, chemical, or peptidomimetic that binds to the WRN gene product or interacts with a protein that binds to the WRN gene product such that the binding of the agonist or antagonist affects the activity of the WRN gene product. An agonist will activate or increase the activity of the WRN gene product. An antagonist will inhibit or decrease the activity of the WRN gene product. The activity of the WRN gene product may be measured in an assay, such as a helicase assay or other assay that measures an activity of the WRN gene product. Other assays measure the binding of protein that interacts with WRN and is necessary for its activity.
Agonists and antagonists of the WRN gene product may be used to enhance activity or inhibit activity of the gene product. Such agonists and antagonists may be identified in a variety of methods. For example, proteins that bind and activate WRN may be identified using a yeast 2-hybrid detection system. In this system, the WRN gene is fused to either a DNA-binding domain or an activating domain of a yeast gene such as GAL4. A cDNA library is constructed in a vector such that the inserts are fused to one of the domains. The vectors are co-transfected into yeast and selected for transcriptional activation of a reporter gene (Fields and Song, Nature 340: 245, 1989). The protein(s) that bind to WRN are candidate agonists. Three different proteins that bind WRN have been identified in an initial screen using the 2-hybrid system.
When the binding site on WRN gene product is determined, molecules that bind and activate WRN protein may be designed and evaluated. For example, computer modeling of the binding site can be generated and mimetics that bind can be designed. Antibodies to the binding site may be generated and analogues of native binding proteins generated as well. Any of these molecules is tested for agonist or antagonist activity by a functional assay of the WRN gene product. For example, to test for antagonist activity, yeast are co-transfected with the WRN and binding protein each fused to a DNA binding domain or an activation domain. The test molecule is administered and activation is monitored. An antagonist will inhibit the activation of the reporter gene by at least 50%. Similarly, agonist activity may be measured by either enhancing WRN activity in a yeast 2-hybrid system or by coupling the test compound to a DNA binding or activation domain and monitoring activity of the reporter gene.
Labels
WRN proteins, nucleic acid molecules which encodes such proteins, anti-WRN protein antibodies and agonists or antagonists, as described above and below, may be labeled with a variety of molecules, including for example, fluorescent molecules, toxins, and radionuclides. Representative examples of fluorescent molecules include fluorescein, Phycobili proteins, such as phycoerythrin, rhodamine, Texas red and luciferase. Representative examples of toxins include ricin, abrin diphtheria toxin, cholera toxin, gelonin, pokeweed antiviral protein, tritin, Shigella toxin, and Pseudomonas exotoxin A. Representative examples of radionuclides include Cu-64, Ga-67, Ga-68, Zr-89, Ru-97, Tc-99m, Rh-105, Pd-109, In-111, I-123, I-125, I-131, Re-186, Re-188, Au-198, Au-199, Pb-203, At-211, Pb-212 and Bi-212. In addition, the antibodies described above may also be labeled or conjugated to one partner of a ligand binding pair. Representative examples include avidin-biotin, and riboflavin-riboflavin binding protein.
Methods for conjugating or labeling the WRN proteins, nucleic acid molecules which encode such proteins, anti-WRN protein antibodies and agonists or antagonists, as discussed above, with the representative labels set forth above may be readily accomplished by one of ordinary skill in the art (see Trichothecene Antibody Conjugate, U.S. Pat. No. 4,744,981,; Antibody Conjugate, U.S. Pat. No. 5,106,951; Fluorogenic Materials and Labeling Techniques, U.S. Pat. No. 4,018,884; Metal Radionuclide Labeled Proteins for Diagnosis and Therapy, U.S. Pat. No. 4,897,255; and Metal Radionuclide Chelating Compounds for Improved Chelation Kinetics, U.S. Pat. No. 4,988,496; see also Inman, Methods In Enzymology, Vol. 34, Affinity Techniques, Enzyme Purification: Part B, Jakoby and Wilchek (eds.), Academic Press, New York, p. 30, 1974, see also Wilchek and Bayer, "The Avidin-Biotin Complex in Bioanalytical Applications," Anal. Biochem. 171:1-32, 1988).
Pharmaceutical Compositions p As noted above, the present invention also provides a variety of pharmaceutical compositions, comprising one of the above-described WRN proteins, nucleic acid molecules, vectors, antibodies, host cells, agonists or antagonists, along with a pharmaceutically or physiologically acceptable carrier, excipients or diluents. Generally, such carriers should be nontoxic to recipients at the dosages and concentrations employed. Ordinarily, the preparation of such compositions entails combining the therapeutic agent with buffers, antioxidants such as ascorbic acid, low molecular weight (less than about 10 residues) polypeptides, proteins, amino acids, carbohydrates including glucose, sucrose or dextrins, chelating agents such as EDTA, glutathione and other stabilizers and excipients. Neutral buffered saline or saline mixed with nonspecific serum albumin are exemplary appropriate diluents.
In addition, the pharmaceutical compositions of the present invention may be prepared for administration by a variety of different routes. In addition, pharmaceutical compositions of the present invention may be placed within containers, along with packaging material which provides instructions regarding the use of such pharmaceutical compositions. Generally, such instructions will include a tangible expression describing the reagent concentration, as well as within certain embodiments, relative amounts of excipient ingredients or diluents (e.g., water, saline or PBS) which may be necessary to reconstitute the pharmaceutical composition.
Methods of Treating or Preventing Werner's Syndrome
The present invention also provides methods for treating or preventing Werner's Syndrome (or related diseases), comprising the step of administering to a patient a vector (e.g., expression vector, viral vector, or viral particle containing a vector) or nucleic acid molecules alone, as described above, thereby reducing the likelihood or delaying the onset of Werner's Syndrome (or the related disease).
Similarly, therapeutic peptides, peptidomimetics, or small molecules may be used to delay onset of Werner's Syndrome, lessen symptoms, or halt or delay progression of the disease. Such therapeutics may be tested in a transgenic animal model that expresses mutant protein, wild-type and mutant protein, or in an in vitro assay system (e.g., a helicase assay such as that described by Bjornson et al., Biochem. 3307:14306-14316, 1994).
As noted above, the present invention provides methods for treating or preventing Werner's Syndrome through the administration to a patient of a therapeutically effective amount of an antagonist or pharmaceutical composition as described herein. Such patients may be identified through clinical diagnosis based on the classical symptoms of Werner's Syndrome.
As will be evident to one of skill in the art, the amount and frequency of administration will depend, of course, on such factors as the nature and severity of the indication being treated, the desired response, the condition of the patient, and so forth. Typically, the compositions may be administered by a variety of techniques, as noted above.
Within other embodiments of the invention, the vectors which contain or express the nucleic acid molecules which encode the WRN proteins described above, or even the nucleic acid molecules themselves may be administered by a variety of alternative techniques, including for example administration of asialoosomucoid (ASOR) conjugated with poly-L-lysine DNA complexes (Cristano et al., PNAS 92122-92126, 1993), DNA linked to killed adenovirus (Curiel et al., Hum. Gene Ther. 3(2):147-154, 1992), cytofectin-mediated introduction (DMRIE-DOPE, Vical, Calif.), direct DNA injection (Acsadi et al., Nature 352:815-818, 1991); DNA ligand (Wu et al., J. of Biol. Chem. 264:16985-16987, 1989); lipofection (Felgner et al., Proc. Natl. Acad. Sci. USA 84:7413-7417, 1989); liposomes (Pickering et al., Circ. 89(1):13-21, 1994; and Wang et al., PNAS 84:7851-7855, 1987); microprojectile bombardment (Williams et al., PNAS 88:2726-2730, 1991); and direct delivery of nucleic acids which encode the WRN protein itself either alone (Vile and Hart, Cancer Res. 53: 3860-3864, 1993), or utilizing PEG-nucleic acid complexes.
The following examples are offered by way of illustration, and not by way of limitation.
EXAMPLES
Example 1
Cloning of the WRN Gene From Chromosome 8
The WS locus (WRN) was initially localized to 8p12 by conventional mapping methods (Goto et al., Nature 355:735-738, 1992) and the genetic position refined using both meiotic and homozygosity mapping (Schellenberg et al., 1992; Nakura, et al., Genomics 23:600-608, 1994; Thomas, Genomics 16:685-690, 1993). The latter approach is possible since many WS subjects are the offspring of consanguineous marriages (Table 1). Initial mapping work (Nakura, et al., Genomics 23:600-608, 1994; Oshima et al., Genomics 23:100-113, 1994) placed the WRN locus in an 8.3 cM interval flanked by D8S137 and D8S87 (FIG. 1). D8S339, a marker within this interval was the closest locus tested (q=0.001, Z.sub.max =15.93). Multipoint analysis placed WRN within 0.6 cM of D8S339, although the region between D8S87 and FGFR could not be excluded. Subsequently, the short tandem repeat polymorphism (STRP) markers at glutathione reductase (GSR) and D8S339 were found to be in linkage disequilibrium with WS in Japanese WS subjects (Yu, American Journal of Human Genetics 55:356-364, 1994).
To clone the WRN gene, a yeast artificial chromosome (YAC) P1, and cosmid contig was generated starting at the GSR/D8S339 region and extended by walking methods to cover approximately 3 Mb. An additional 16 STRP markers in the YAC contig (FIG. 1B) were identified to define recombinants and to delineate the boundaries of the linkage disequilibrium region. For marker ordering and gene identification, cosmids and P1 clones were also isolated and used to construct a small-clone partial contig of the region (FIG. 1E). The WRN region was defined by obligate recombinants at C41C3S3 excluding the region telomeric to this marker, and at y896R9 excluding the region centormeric to this marker. Thus, the region from C41C3S2 to y896R9, which is approximately 1.2 Mb (FIG. 1C), was considered the minimal WRN region.
Genes in the WRN region were identified by exon trapping using vector pSL3 (Buckler et al., Proc. Natl. Acad. Sci. USA 88:4005-4009, 1991; Church et al., Nat. Genet. 6:98-105, 1994), hybridization of cDNA libraries to immobilized YACs (Parimoo et al., Proc. Natl. Acad. Sci USA 87:3166-3169, 1991), and comparison of the genomic sequence to DNA sequence databases using BLAST (Altschyl et al. J. Mol. Biol. 215:403-410, 1990) and the exon-finding program GRAIL (Uberbacher and Mural, Proc. Natl. Acad. Sci. USA 88:1261, 1991). The genomic sequence was determined for the region defined by P1 clones 2233, 2253, 3833, 2236, 2237, 2932, 6738 and 2934 and cosmid clone 176 C6. Each method identifies short segments of expressed sequences, which were then used to screen an arrayed fibroblast cDNA library to identify longer cDNA clones. This library was selected because WS fibroblasts have a premature senescence phenotype in vitro, indicating that the WRN gene is probably expressed in this cell type. Genes identified by this process were screened for WRN mutations using reverse transcriptase-polymerase chain reaction (RT-PCR). Seven subjects were initially screened for mutations: 5 WRN subjects (2 Caucasians and 3 Japanese) and 2 control subjects (1 Caucasian and 1 Japanese). Prior to identification of the WRN gene, the following genes from the region were screened for mutations; GSR, PP2AB, TFIIEB, and genes corresponding to other expressed sequence tagged sites (ESTs).
The candidate WRN locus gene was initially detected by using the genomic sequence of P1 clone 2934 to search the EST database. A single 245 bp EST, R58879, was detected which is homologous to 3 segments of the genomic sequence separated by presumed intronic sequence. Sequence from R58879 was used to identify longer cDNA clones from a normal fibroblast cDNA library. An initial 2.1 kb cDNA clone containing EST R58879, which corresponds to the 3' end of the gene, was obtained by screening an array of clones by PCR, using the primers A and B (see below). Primers A and B are derived from R58879 sequence and yield a 145 bp fragment after amplification. Longer clones were identified by PCR screening with primers 5EA and 5EB, which were derived from sequences within a predicated exon located in p2934 and 5' to sequences contained in the initial 2.1 kb clone. Six additional clones were identified. An additional 8 clones were obtained by plaque hybridization. The longest clone is 4.0 kb in length. Additional sequence was obtained by the RAGE method using primer 5EA to prime first strand cDNA synthesis. A 2.5 kb product was obtained that contained an additional 1.4 kb of sequence.
Evidence that R58879 is expressed was obtained by Northern blot analysis, in which 6.5 kb and 8 kb transcripts were detected in a variety of tissues, including heart, placenta, muscle, and pancreas. Also, transcripts were detected by RT-PCR products from fibroblast and lymphoblastoid cell line RNA.
Example 2
Cloning of the WRN Gene from Subjects
The WRN gene may be isolated from patients and mutations or polymorphisms determined by sequence analysis. Peripheral blood cells are obtained by venipuncture and hypotonic lysis of erythrocytes. DNA or RNA is isolated from these cells and the WRN gene isolated by amplification. The gene sequence may be obtained by amplification of the exons from genomic DNA or by RT-PCR, followed by determination of the DNA sequence. Primers suitable for determining the DNA sequence and for performing RT-PCR are listed below (Primers A-R are SEQ ID Nos. 1-18 respectively, and primers 5EA-5EG are SEQ ID Nos. 19-25 respectively). Two cDNAs were identified and are shown in FIGS. 2 and 3. There is some uncertainty regarding the identity of a few bases in the 5' untranslated region in FIG. 2.
Two RT-PCR reactions are used to obtain the gene from different tissues. First strand cDNA synthesis is carried out according to standard procedures (e.g., with a Stratascript Kit from Stratagene). The cDNA is subjected to a pair of nested PCR amplifications, the first with primers I and J (SEQ ID Nos. 9 and 10), followed by primers K and L (SEQ ID Nos. 11 and 12), and the second with primers 5ED and P(SEQ ID Nos. 22 and 16), followed by primers 5EE and B (SEQ ID Nos. 23 and 2). These fragments are isolated and used for sequencing to identify differences in the gene sequence or splicing pattern. Primers A-H (SEQ ID Nos. 1-8) and K-R (SEQ ID Nos. 11-18) are used for sequencing the first RT-PCR fragment. Primers B, 5EA, 5EB, 5EC, 5EE, 5EF and 5EG (SEQ ID Nos. 2, 19, 20, 21, 23, 23, and 25, respectively) are used for sequencing the second RT-PCR fragment. Sequencing is done on an ABI373A using Applied Biosystems Division of Perkin-Elmer FS sequencing kits according to the instructions of the manufacturer.
______________________________________A 5'-CTGGCAAGGATCAAACAGAGAGB 5'-CTTTATGAAGCCAATTTCTACCCC 5'-TGGCMAUGGTAGMGCTAGGD 5'-AAATAAACTATGCTTTCTTACATTTACE 5'-CTCCCGTCMCICAGATAJGAGF 5'-CTGTTTGTAAATGAAAGAAAGCATAGG 5'-GAGCTATGATGACACCACTGCY 5'-ACTGAGCAACAGAGTGAGACCJ 5'-GGATCTGGTCTCACTCTGTTGCJ 5'-TTGCCTAGTGCAATTGGTCTCCK 5'-AGTGCAGTGGTGTCATCATAGCL 5'-CCTATTTAATGGCACCCAAAATGCM 5'-CAGTCTATGGCCATCACATACTCN 5'-ACCGCTTGGGATAAGTGCATGCO 5'-GAGAAGAAGTCTAACTTGGAGAAGP 5'-TTCTGGTGACTGTACCATGATACQ 5'-CCAAAGGMGTGATACCAGCAAGR 5'-ACAGCAAGAAACATAATTGTTCTGG5EA 5'-GAACTTTGAAGTCCATCACGACC5EB 5'-GCATTAATAAAGCTGACATTCGCC5EC 5'-CATTACGGTGCTCCAAGGACATG5ED 5'-GATGGATTTGAAGATGGAGTAGAAG5EE 5'-TGAAAGAGAATATGGAAAGAGCTTG5EF 5'-GTAGAACCAACTCATTCTAAATGCT5EG 5'-AATTTGCGTGTCATCCTTGCGCA______________________________________
The exons of the 3'-end of the WRN gene can be amplified from DNA samples using the primers listed below (Primers E1A-E13B are SEQ ID Nos. 26-57, respectively). The DNA sequence is determined using the same primers and an ABI373A automated sequencer using Applied Biosystems Division of Perkin-Elmer FS sequencing kits according to the instructions of the manufacturer.
______________________________________E1A 5'-TCCTAGTCACCCATCTGAAGTCE1B 5'-CATGAAACTTGCTTCTAGGACACE2A 5'-CCCAGGAGTTCGAGACCATCCE2B 5'-TTACAATCGGCCACATTCATCACE2C 5'-TGTAATCCCAACACTTTGGGAGGE2D 5'-AGTGGAAGAATTCATAGTGGATGGE3A 5'-TAGCTTTATGAAGCCAATTTCTACCE3B 5'-AATCCAAAGAATCAATAGACAAGTCE3C 5'-GCTTGAAGGATGAGGCTCTGAGE3D 5'-TGTTCAGAATGAGCACGATGGGE4A 5'-CTTGTGAGAGGCCTATAAACTGGE4B 5'-GGTAAACAGTGTAGGAGTCTGCE5A 5'-GCCATTTTCTCTTTAATTGGAAAGGE5B 5'-ATCTTATTCATCTTTCTGAGAATGGE6A 5'-TGAAATAGCCCAACATCTGACAGE6B 5'-GATTAATTTGACAGCTTGATtAGGCE7A 5'-TGAAATATAAACTCAGACTCTTAGCE7B 5'-GTACTGATTTGGAAAGACATTCTCE8A 5'-GATGTGACAGTGGAAGCTATGGE8B 5'-GGAAAAATGTGGTATCTGAAGCTCE9A 5'-AAGTGAGCAAATGTTGCTTCTGGE9B 5'-TCATTAGGAAGCTGAACATCAGCE10A 5'-GTTGGAGGAAATTGATCCCAAGTCE10B 5'-TGTTGCTTATGGGTTTAACTTGTGE11A 5'-TAAAGGATTAATGCTGTTCAGTGE11B 5'-TCACACTGAGCATTTACTACCTGE12A 5'-GTAATCATATCAGAATTCATAACAGE12B 5'-CTTTGGCAACCNTTCACCTTCCE12C 5'-GCAAAGGAAATGTAGCACATAGAGE12D 5'-AGGCTATAGGCATTTGAAAGAGGE13A 5'-GTAGGCTCCCAGAAGACCCAGE13B 5'-GAAAGGATGGGTGTGTATTCAGG______________________________________
Example 3
Identification of Mutant Alleles
The cDNA sequence (FIG. 2) was aligned to the genomic sequence to identify the exon structure, and primers synthesized for PCR amplification of each exon. DNA sequence of all 13 exons were determined for 5 patients and two unaffected individuals. In 4 of 5 patients, single base pair changes lead to splicing defects or stop codons in the open reading frame of the gene. In the fifth patient, a single base pair change results in a cystein to arginine transition which may disrupt gene function. Each of the exons was also sequenced in 96 unaffected control individuals (48 Caucasians and 48 Japanese), and none of the mutations were found in any of the control individuals.
The first mutation is a mutation at a splice acceptor site. In the sequence below, the GGTAGAAA sequence begins at nucleotide 2030 (FIG. 2). The g to c change results in a deletion of 95 bp.
Preparation of DNA for RT-PCR mutational analysis revealed that for one subject, the amplification product was shorter than observed in products from other WS and control subjects. DNA sequence analysis of the RT-PCR product revealed that 95 bp were missing compared to other samples. The missing sequence corresponds to a single exon. This exon and flanking genomic segments were sequenced from the WS subject and controls and a single base change (G.fwdarw.C) at the splice donor site was detected. The subject was the offspring of a first cousin marriage and was, as expected, homozygous for this mutation. The same mutation was found in a total of 18 out of 30 Japanese WS subjects and, thus, is the most common Japanese WS mutation. Deletion of this exon results in a change in the predicted open-reading frame and a premature stop codon. This mutation was not observed in 46 Japanese and 46 Caucasian controls. Among mutation carriers, 12/16 had the 141 bp allele at the GSR2-STRP.
wild type: ttttaatagGGTAGAAA (SEQ ID No. 58)Werners: ttttaatacGGTAGAAA (SEQ ID No. 59)
The second mutation changes a C to T at nucleotide 2384 (FIG. 2) changing a glutamine to a stop codon, which results in a predicted truncated protein. This mutation was observed in a single subject. Primers E11A and E11B flank this sequence and amplify a 360 bp fragment.
glnwild type: GAAGCTAGGCAGAAACAT (SEQ ID No. 60)Werners: GAAGCTAGGTAGAAACAT (SBQ ID No. 61) ter
The third mutation changes a C to T at nucleotide 2804 (FIG. 2), which alters an arginine codon to a stop codon resulting in a predicted truncated protein. Four Japanese WS subjects and 1 Caucasian W5 subject had this mutation. Primers E8A and E8B flank this sequence and amplify a 267 bp product.
argwild type: TTGGAGCGAGCA (SEQ ID No. 62)Werners: TTGGAGTGAGCA (SEQ ID No. 63) ter
The fourth mutation is a 4 bp deletion across a splice junction. The exon sequence shown below begins at nucleotide 2579 (FIG. 2). This mutation was identified in a Syrian W5 kindred. Primers E4A and E4B flank this mutation and amplify a 267 bp fragment.
wild type: ctgtagACAGACACCTC (SEQ ID No. 68)Werners: ctgt----AGACACCTC (SEQ ID No. 69)
The fifth mutation is a missense mutation. A T is altered to a G at nucleotide 2113 (FIG. 2), changing the wild-type phe codon to a leu codon. This change is a polymorphism with each allele present at a frequency of approximately 0.5. It does not appear to correlate with WS.
phewild type: AAGAAGTTTCTTCTG (SEQ ID No. 64)Werners: AAGAAGTTGCTTCTG (SEQ ID No. 65) leu
The sixth mutation is a missense mutation changing a T to a C at nucleotide 2990 (FIG. 2) and a cys codon to an arg codon.
cyswild type: CCTTCATGTGAT (SEQ ID No. 66)Werners: CCTTCACGTGAT (SEQ ID No. 67)
These point mutations may also be identified by PCR using primers that contain as the 3'-most base either the wild type or the mutant nucleotide. Two separate reactions are performed using one of these primers and a common second primer. Amplification is detectable in the reaction containing a matched primer.
Example 4
Characterization of the WRN Gene and Gene Product
The 2 kb WRN cDNA hybridizes to a 6.5 kb RNA and a less abundant 8 kb RNA on a Northern blot, suggesting that a full length coding region is about 5.2 kb long. An overlapping cDNA clone has been isolated that extends the sequence by 2 kb. The insert from this clone is used to probe cDNA libraries to identify other clones that contain the 5' end of the cDNA or full length sequence. Alternate splicing events are detected by sequencing the full cDNA sequence from a number of different tissues, including fully differentiated cells and stem cells, and the full range of gene transcripts identified by sequence comparison. Additional exons are identified as above by further genomic sequencing and GRAIL analysis.
The predicted amino acid sequence is shown in FIGS. 2B and 3. FIG. 2 shows cDNA and predicted amino acid sequences of the WRN gene. FIG. 3 presents cDNA and predicted amino acid sequences of a less abundant transcript of the WRN gene. The longest open reading frame is shown from the first methionine in that frame. The predicted WRN protein consists of 1,432 amino acids divided into three regions: an N-terminal region, a central region containing 7 motifs (I, Ia, II, III, IV, V and VI) characteristic of the DNA and RNA superfamily of helicases (Gorbalenya et al. Nucleic Acid Res. 17: 4713, 1989), and a C-terminal region (FIG. 8). Unlike the central region, the N-terminal and C-terminal domains of the predicted protein do not show amino acid identity to other helicases or to any previously described protein. Because many helicases function as part of a multiprotein complex, the N-terminal and/or the C-terminal domain may contain interaction sites for these other proteins, while the central helicase domain functions in the actual enzymatic unwinding of DNA or RNA duplexes.
The N-terminal region, encompassing approximately codons 1 to 539, is acidic; there are 109 aspartate or glutamate residues, including a stretch of 14 acidic residues in a 19 amino acid sequence (codons 507-526). Stretches of acidic residues are found in the Xeroderma pigmentosum (XP) complementation group B helicase, the Bloom's syndrome helicase, and the X-chromosome-linked .alpha.-thalassemia mental retardation syndrome helicase. In the WRN gene, this region also contains a tandem duplication of 27 amino acids in which each copy is encoded by a single exon. Because this duplication is exact at the nucleotide level, and because flanking intronic sequences for the two exons that encode the duplication are also highly similar, this duplication is presumed to be the result of a relatively recent event. The duplicated regions are also highly acidic with 8 glutamate or aspartate residues out of 27 amino acids and only 2 basic amino acids (one histidine and one lysine residue).
The central region of the WRN gene, spanning approximately codons 540-963, is highly homologous to other helicases from a wide range of organisms including the ReqQ gene from E. coli, the SGS1 gene from S. cerevisiae, a predicted helicase (F18C5C) from C. elegans, and several human helicases. Thus, by sequence similarity, the WRN gene is a member of a superfamily of DExH-box DNA and RNA helicases. The principle conserved sequences consist of 7 motifs found in other helicases. These motifs include a predicted nucleotide binding site (motif I) and a Mg.sup.2+ binding site (sequence DEAH, motif II). Some or all of the 7 motifs are presumed to form the enzymatic active site for DNA/RNA unwinding. The presence of the DEAH sequence and an ATP-binding motif further suggests that the WRN gene product is a functional helicase.
The C-terminal end of the WRN gene, from codons 964 to 1432, has limited identity to other genes. The only identity identified is a loose similarity to E. Coli ReqQ gene and C. elegans gene F18C5.2.
Example 5
Identifying and Detecting Mutations in the WRN Gene
Mutations or polymorphisms of WRN may be identified by various methods, including sequence analysis. Although any cell (other than erythrocytes) may be used to isolate nucleic acids, peripheral blood mononuclear cells (PBMC) are preferred. Peripheral blood mononuclear cells are obtained by venipuncture and subsequent hypotonic lysis of erythrocytes. RNA is isolated and first strand cDNA synthesis is performed using a Strata-script RT-PCR kit according to the manufacturers instructions (Stratagene, La Jolla, part numbers 200347 and 200420). Three RT-PCR fragments are amplified using an LA PCR Kit Ver. 2 using buffer containing 1.5 mM Mg+2 (TaKaRa Shuzo Co., Ltd., Japan, part number RR013A). Nested PCR is performed. In this reaction, a second PCR is performed using a pair of primers within the sequence amplified by the first PCR reaction. The cycling conditions for each amplification are: 10 min at 95.degree. C., 35 cycles of 1 min at 60.degree. C., 1 min at 72.degree. C., and 1 min at 95.degree. C., followed by 7 min at 72.degree. C. in a Perkin-Elmer 9600 PCR machine. The amplified fragments are purified using 96-well plate spin columns (Wang et al., Anal. Biochem. 226:85-90, 1995). DNA sequence is determined using an FS Dye-Terminator sequencing kit (Applied Biosystems Division of Perkin Elmer) and the specific primers described below. An automated Applied Biosystems ABI373A DNA Sequencer is used to determine the sequence. The amplified fragments and the appropriate primers are listed in Table 1, and the primer sequences are listed in Table 2.
The DNA sequences are aligned with the known sequence (FIG. 2A) using the program Sequencher (Gene Codes, Michigan) to identify any discrepancies between patient samples and the reference sequence.
TABLE 1______________________________________PCR and sequence primers Primers NestedFrag- on cDNAment 1st PCR 2nd PCR Coordinates Sequence primers______________________________________I 5EC, J 5EN, L 2947-5065 5EN, L, M, N, O, P, Q, RII 5ED, P 5EE, B 1379-3391 5EE, 5EJ, 5EK, 5EL, 5EM, 5EB, 5EA, 5EN, BIII 5ES, 5EK 5ET, 5EH 75-1516 5ET, 5EX, 5E1, 5EP, 5EO, 5ED, 5EH______________________________________
TABLE 2______________________________________Primer sequences______________________________________B 5'-CTTTATGAAGCCAATTTCTACCC (SEQ ID No. 2)J 5'-TTGCCTAGTGCAATTGGTCTCC (SEQ ID No. 10)L 5'-CCTATTTAATGGCACCCAAAATGC (SEQ ID No. 12)M 5'-CAGTCTATGGCCATCACATACTC (SEQ ID No. 13)N 5'-ACCGCTTGGGATAAGTGCATGC (SEQ ID No. 14)o 5'-GAGAAGAAGTCTAACTTGGAGAAG (SEQ ID No. 15)P 5'-TTCTGGTGACTGTACCATGATAC (SEQ ID No. 16)Q 5'-CCAAAGGAAGTGATACCAGCAAG (SEQ ID No. 17)R 5'-ACAGCAAGAAACATAATTGTTCTGG (SEQ ID No. 18)5EA 5'-GAACTTTGAAGTCCATCACGACC (SEQ ID No. 19)5EB 5'-GCATTAATAAAGCTGACATTCGCC (SEQ ID No. 20)5EC 5'-CATTACGGTGCTCCTAAGGACATG (SEQ ID No. 21)5ED 5'-GATGGATTTGAAGATGGAGTAGAAG (SEQ ID No. 22)5EE 5'-TGAAAGAGAATATGGAAAGAGCTTG (SEQ ID No. 23)5EH 5'-CATTGGGAGATAAATGCTCAGTAGA (SEQ ID No. 80)5EJ 5'-AGATGTACTTTGGCCATTCCAG (SEQ ID No. 81)5EK 5'-GCCATGACAGCAACATTATCTC (SEQ ID No. 82)5EL 5'-CTTACTGCTACTGCAAGTTCTTC (SEQ ID No. 83)5EM 5'-TCGATCAAAACCAGTACAGGTG (SEQ ID No. 84)5EN 5'-GCAGATGTAGGAGACAAATCATC (SEQ ID No. 85)5EO 5'-TCATCCAAAATCTCTAAATTTCGG (SEQ ID No. 86)5EP 5'-CTGAGGACCAGAAACTGTATGC (SEQ ID No. 87)5ES 5'-GCTGATTTGGTGTCTAGCCTGG (SEQ ID No. 88)5ET 5'-TGCCTGGGTTGCAGGCCTGC (SEQ ID No. 89)5EX 5'-TTGGAAACAACTGCACAGCAGC (SEQ ID No. 90)5E1 5'-GATCCAGTGAATTCTAAGAAGGG (SEQ ID No. 91)______________________________________
Example 6
Isolation of Genomic DNA Containing Werner's Syndrome Gene
To facilitate mutational analysis of the WRN gene, the intron-exon structure is determined. The WRN gene is located in the genomic sequence of P1 clone 2934. However, this clone only contains the 3' end of the gene (exons 21 to 35). Genomic clones containing the 5' end are obtained from a chromosome 8-specific cosmid library LA08NC01 (Wood et al. Cytogenet. Cell Genet. 59: 243, 1992) by screening for clones adjacent to P1 clone 2934. Briefly, this library is arrayed for PCR screening as described in Amemiya et al. (Nucl. Acids Res. 20: 2559, 1992). WRN containing cosmids are identified using primer sets 5E6/5EY, 5ED/5E12, and CD-A/CD-B (Table 3), which are derived from the WRN cDNA sequence (FIG. 1; GenBank Accession No. L76937). Four walking steps yielded cosmids 193B5, 114D2, 78D8 and 194C3, which contained the remaining exons. Primers derived from the WRN cDNA were used for the initial sequence analysis of the cosmid clones. The resulting sequence (FIG. 5) is compared to the cDNA sequence to identify intron-exon boundaries. Sequencing primers are then designed from the intron sequences to obtain sequence in the reverse direction and to obtain the second boundary defining the intron-exon junction. This strategy is used to define the exons not present in P1 clone 2934.
TABLE 3__________________________________________________________________________Primer sequence and PCR conditions for WRN analysis Product Mg.sup.+2Region Primer Sequence Size (bp) (mM) pH__________________________________________________________________________N-domain 5E6 5'-GATATTGTTTTGTATTTACCCATGAAGAC (SEQ ID No. 164) 106 1.5 8.3 5EY 5'-TCCGCTGCTGTGCAGTTGTTTCC (SEQ ID No. 165)center 5ED 5'-GATGGATTTGAAGATGGAGTAGAAG (SEQ ID No. 22) 158 2.0 8.3domain 5E12 5'-TCAGTAGATTTATAAGCAATATCAC (SEQ ID No. 166)C-domain CD-A 5'-CTGGCAAGGATCAAACAGAGAG (SEQ ID No. 167) 144 2.0 8.3 CD-B 5'-CTTTATGAAGCCAATTTCTACCC (SEQ ID No. 168)__________________________________________________________________________
The annealing temperature was 60.degree. C. for all primer sets.
Table 4 presents a summary of the structure of the genomic WRN gene. The first column identifies the exon, the second column indicates the base numbers of the cDNA that are derived from the exon, the third column denotes the size of the exon in bp, the fourth column shows the sequence of the boundaries with intron sequences in lower case letters and exon sequences in upper case letters, the fifth column shows notable features of the exons.
TABLE 4__________________________________________________________________________Intron-Exon Structure of the WRN Gene Exon cDNA SizeExon Location (bp) Intron-Exon Boundary Sequences Exon Features__________________________________________________________________________1 1-155 >155 (SEQ ID No. 169) . . . TTCTCGGGgtaaagtgtc 5'UTR2 156-327 172 tacctctcagTTTTCTTTt . . . AAAGAAAGgtatgttgtt 5'UTR, ATG codon (SEQ ID No. 170)3 328-440 113 taaactcaagGCATGTGT . . . GATATTAGgtaagtgatt (SEQ ID No. 171)4 441-586 146 ctcactttagCATGAGTC . . . CATGTCAGgttggtatct (SEQ ID No. 172)5 587-735 149 aatgttacagTTTTTCCC . . . ATAAAAAGgtaaaagcaa (SEQ ID No. 173)6 736-885 150 tcatttctagCTGAAATG . . . ATGCTTATgtacgtgctt (SEQ ID No. 174)7 886-955 70 ttttttatagGCTGGTTT . . . AAATAAAGgtatgttaag (SEQ ID No. 175)8 956-1070 115 ttccccctagAGGAAGAA . . . CCACGGAGgttaaatatt (SEQ ID No. 176)9 1071- 430 ttttttttagGGTTT CTA . . . CTACTGAGgtactaaaat 1500 (SEQ ID No. 177)10 1501- 81 ttttttaaagCATTTATC . . . TGCTTAAGggtatgttta duplicated exon 1581 (SEQ ID No. 178)11 1582- 81 ttttttaaagCATTTATC . . . TGCTTAAGggtatgttta duplicated exon 1662 (SEQ ID No. 179)12 1663- 145 aaactttcagTCTTTAGA . . . TGATAAGGgtaagcactg 1807 (SEQ ID No. 180)13 1808- 76 ttatttccagACTTTTTG . . . TTTAAACCgtgagtataa 1883 (SEQ ID No. 181)14 1884- 68 caccttcaagAGTTCAGT . . . GGCAACTGgtaagttgta helicase motif I 1951 (SEQ ID No. 182) (5' end)15 1952- 109 tcatttcaagGATATGGA . . . CAGcllAAgtaagtcatg helicase motif I 2060 (SEQ ID No. 183) (3' end) and Ia16 2061- 69 cttcttatagAATGTCCA . . . ATTAAATTgtgagtaatt 2129 (SEQ ID No. 184)17 2130- 83 gtttttacagAGGTAMT . . . TGATATTGgtaagtgata 2212 (SEQ ID No. 185)18 2213- 107 ttttttacagGTATCACG . . . TGCCAATGgtaagctttg helicase motif 2319 (SEQ ID No. 186) II19 2320- 185 catcattcagGTTCCAAT . . . AAAACAAGgtaaggattt helicase motif 2504 (SEQ ID No. 187) III20 2505- 175 ttttctttagTTCCCACT . . . AAAJJCAGgtatgaggat helicase motif 2679 (SEQ ID No. 188) IV21 2680- 182 ttgttctcagTGTGTCAT . . . TTAAATAGgtaaaaaaaa helicase motifs 2861 (SEQ ID No. 189) V and VI22 2862- 102 taatcgacagGCACCTTC . . . AGGAGACAgtatgtatta 2963 (SEQ ID No. 190)23 2964- 93 tcttgggtagAATCATCT . . . AGGTCCAGgtaaagattt 3056 (SEQ ID No. 191)24 3057- 142 ttttatttagATTGGATC . . . GAGGATCTgtaagtatat 3198 (SEQ ID No. 192)25 3199- 171 ctaatttcagAATTCTCA . . . CGAAAAAGgtaaacagtg 3369 (SEQ ID No. 193)26 3370- 95 cttttaatagGGTAGAAA . . . CTGCCTAGgttcattttt 3464 (SEQ ID No. 194)27 3465- 76 tattttttagTTCGAAAA . . . AGAAGAAGgtttgtttta 3540 (SEQ ID No. 195)28 3541- 74 ttaaatgcagTCTAACTT . . . AAAAAAAGgtacagagtt 3614 (SEQ ID No. 196)29 3615- 76 aatattttagTATCATGG . . . AGACTCAGgtaaggcttt 3690 (SEQ ID No. 197)30 3691- 113 ttttgttcagATTGTGTT . . . AAAATGAGggtaaactatc 3803 (SEQ ID No. 198)31 3804- 115 ttaaacacagATTAACTA . . . GTGTTCAGgtaaaatact 3918 (SEQ ID No. 199)32 3919- 132 aattctgtagACAGACCT . . . TGCCTTTGgtaagtgtga 4050 (SEQ ID No. 200)33 4051- 163 ctttctctagAAGAGCAT . . . CAACTCAGgtgagaggca 4213 (SEQ ID No. 201)34 4214- 209 tcgtttacagATATGAGT . . . ATACTGAGgtattaatta 4422 (SEQ ID No. 202)35 4423- 768 tttcctacagACTTCATC . . . TAA codon, 3'UTR 5190 (SEQ ID No. 203)__________________________________________________________________________ Note. Exons are in uppercase and intron sequences are in lowercase letters.
As shown above, WRN contains a total of 35 exons ranging in size from 68 bp (exon 14) tp 768 bp (exon 35). The coding region begins in the second exon (Table 2). As noted previously, there is a duplicated region in the WRN cDNA sequence which is 27 amino acids in length. This duplication is exactly conserved at the nucleotide level in cDNA. At the genomic level, the duplicated sequences were present as 2 exons (exons 10 and 11), each exon containing only the duplicated nucleotides. The intronic sequences adjacent to these 2 exons are also highly conserved, suggesting that the a relatively recent duplication event is responsible for these repeated exons. In addition, because the surrounding intronic sequences were conserved, it was not possible to design primers which could specifically amplify exons 10 and 11.
The helicase region of the WRN gene is contained in exons 14-21. Helicase motif 1 is split between exons 14 and 15 while the remaining motifs are each in an individual exon (Table 4). This region, from codon 569 to 859, has sequence similarity to the 7 signature helicase motifs. In addition, though the sequences between the motifs are not conserved, the spacing is very similar in genes from a wide range of species. For example, the helicase domains in the E. coli RecQ gene are found in a stretch of 288 amino acids compared to 291 amino acids for the WRN gene.
Example 7
Identification of Mutations
Initially, 4 different mutations in the C-terminal domain of WRN were identified. These mutations accounted for more than 80% of the Japanese WS patients examined. All 4 mutations are in the C-terminal domain region of WRN and the resulting predicted protein contains an intact helicase domain. Additional WS subjects are screened to identify further mutations. Genomic structure information is used to design PCR-primers for amplifying each exon, which is then subjected to DNA sequence analysis. Five additional WRN mutations are described; 2 are located in the consensus helicase motifs and another 2 are predicted to produce truncated proteins without the helicase domains. These mutations suggest that in at least some WS subjects, the enzymatic helicase activity is destroyed and support that complete loss-of-function of WRN gene product causes Werner's syndrome.
Although any cell may be used to isolate DNA, PBMC are preferred. As above, PBMC are obtained by venipuncture and subsequent hypotonic lysis of erythrocytes. PBMC are lysed by the addition of detergent, such as 0.5% NP-40, 0.5% Triton-X100, or 0.5% SDS. If a non-ionic detergent is used, no further purification of DNA is necessary, but proteinase K treatment, and subsequent heat killing of the enzyme (95.degree. C. for 10 minutes) is required. Genomic DNA is amplified according to the PCR conditions recited above using the primers listed in Table 5. Exons 9 and 10 are contained in a region of DNA that is duplicated. The primer pair for exon 9 and 10 anneals to sequences outside the duplication. Amplified product is analyzed by DNA sequence determination, hybridization with allele-specific probe, or other mutation detection method. When DNA sequences are determined, the sequence of the amplified exon is aligned with the known sequence (FIG. 2A) and any discrepancies between patient samples and the reference sequence are identified.
TABLE 5__________________________________________________________________________PCR Product Mg.sup.+2Fragment Primer Sequence Size (bp) (mM) pH__________________________________________________________________________exon 1 A 5'-AGGGCCTCCACGCATGACGC 583 1.5 8.3 (SEQ ID No. 92) B 5'-AGTCTGTTTTTCCAGAATCTCCC (SEQ ID No. 93)exon 2 A 5'-CCTATGCTTGGACCTAGGTGTC 339 1.5 8.3 (SEQ ID No. 94) B 5'-GAAGTTTACAAGTAACAACTGACTC (5EQ ID No. 95)exon 3 A 5'-ACTATAAATTGAATGCTTCAGTGAAC 316 1.5 8.3 (SEQ ID No. 96) B 5'-GAACACACCTCACCTGTAAAACTC (SEQ ID No. 97)exon 4 E 5'-GGTAAACCACCATACCTGGCC 691 1.5 8.3 (SEQ ID No. 98) F 5'-GTACATATCCTGGTCATTTAGCC (SEQ ID No. 99)exon 5 B 5'-ATTCAGATAGAAAGTACATTCTGTG 369 1.5 8.3 (SEQ ID No. 101) E 5'-GTTAAGAAATACTCAAGGTCAATGTG (SEQ ID No. 101)exon 6 A 5'-GGTTGTATTTTGGTATAACATTTCC 374 1.5 8.3 (SEQ ID No. 102) B 5'-ATATTTTGGTAGAGTTTCTGCCAC (SEQ ID No. 103)exon 7 A 5'-CTCTTCGATTTTTCTGAAGATGGG 291 1.5 8.3 (SEQ ID No. 104) B 5'-CCCTAATAGTCAGGAGTGTTCAG (SEQ ID No. 105)exon 8 A 5'-GGAAAGAAAATGAAAATTTGATCCC 316 4.0 8.3 (SEQ ID No. 106) B 5'-CAGCCTTAATGAATAGTATTCTTCAC (SEQ ID No. 107)exon 9 C 5'-ATTGATCTTTTAAGTGAAGGTCAGC 668 1.5 8.3 (SEQ ID No. 108) D 5'-CTGCAACAGAGACTGTATGTCCC (SEQ ID No. 109)exon 12 A 5'-GCTTTCGACAAAATTGTAGGCCC 337 1.5 9.0 (SEQ ID No. 110) B 5'-CCAAACCATCCAAAACTGGATCCexon 13 A 5'-TAACCCATGGTAGCTGTCACTG 285 1.5 8.3 (SEQ ID No. 112) B 5'-CTGTTGCTGTTAAGCAGACAGG (SEQ ID No. 113)exon 14 C 5'-TTGAATGGGACATTGGTCAAATGG 348 1.5 8.3 (SEQ ID No. 114) F 5'-GTAGTTGCATTTGTATTTTGAGAGT (SEQ ID No. 115)exon 15 C 5'-GTAAAAAGAAATGAAAGCATCAAAGG 246 4.0 8.3 (SEQ ID No. 116) D 5'-TCACCCACAGAAGAAAAAAAGAGG (SEQ ID No. 117)exon 16 A 5'-CAAAAAAGAAAATTGCAAAGAACAGG 282 4.0 8.3 (SEQ ID No. 118) B 5'-CAGCAACATGTAATTCACCCACG (SEQ ID No. 119)exon 17 5'-GAAGAGACTGGAATTGGGTTTGG 532 1.5 8.3 (SEQ ID No. 120) 5'-ATAGAGTATCATGGGATAAGATAGG (SEQ ID No. 121)exon 18 A 5'-TTCTCCTTTGGAGATGTAGATGAG 273 4.0 10 (SEQ ID No. 122) B 5'-TCTTCAGCTTCTTTACCACTCCCCA (SEQ ID No. 123)exon 19 A 5'-CATGGTGTTTGACAACAGGATGG 396 4.0 9.0 (SEQ ID No. 124) B 5'-GTTAAATATGCATTAGAAGGAAATCG (SEQ ID No. 125)exon 20 A 5'-ATAAAACCAAACGGGTCTGAAGC 342 4.0 8.3 (SEQ ID No. 126) B 5'-AAAAGAAGTATTCAATAAAGATCTGG (SEQ ID No. 127)exon 21 A 5'-AATTCCACTTTGTGCCAGGGACT 397 1.5 9.0 (SEQ ID No. 128) B 5'-ACTTGGGATACTGGAAATAGCCT (SEQ ID No. 129)exon 22 A 5'-TTTTTATCTTGATGGGGTGTGGG 356 1.5 9.0 (SEQ ID No. 130) B 5'-AAATTCAGCACACATGTAACAGCA (SEQ ID No. 131)exon 23 A 5'-CTGAAGTCAAATAATGAAGTCCCA 360 4.0 8.3 (SEQ ID No. 132) B 5'-GTTTGCTTCTCATATCTAAACACA (SEQ ID No. 133)exon 24 A 5'-CTTGTGAGAGGCCTATAAACTGG 267 1.5 8.3 (SEQ ID No. 134) B 5'-GGTAAACAGTGTAGGAGTCTGC (SEQ ID No. 135)exon 25 C 5'-GCTTGAAGGATGAGGCTCTGAG 461 1.5 8.3 (SEQ ID No. 136) D 5'-TGTTCAGAATGAGCACGATGGG (SEQ ID No. 137)exon 26 A 5'-CTTGTGAGAGGCCTATAAACTGG 267 1.5 8.3 (SEQ ID No. 138) B 5'-GGTAAACAGTGTAGGAGTCTGC (SEQ ID No. 139)exon 27 A 5'-GCCATTTTCTCTTTAATTGGAAAGG 274 1.5 8.3 (SEQ ID No. 140) B 5'-ATCTTATTCATCTTTCTGAGAATGG (SEQ ID No. 141)exon 28 A 5'-TGAAATAGCCCAACATCTGACAG 291 1.5 8.3 (SEQ ID No. 142) B 5'-GATTAATTTGACAGCTTGATTAGGC (SEQ ID No. 143)exon 29 A 5'-TGAAATATAAACTCAGACTCTTAGC 303 1.5 8.3 (SEQ ID No. 144) B 5'-GTACTGATTTGGAAAGACATTCTC (SEQ ID No. 145)exon 30 A 5'-GATGTGACAGTGGAAGCTATGG 307 1.5 8.3 (SEQ ID No. 146) B 5'-GGAAAAATGTGGTATCTGAAGCTC (SEQ ID No. 147)exon 31 A 5'-AAGTGAGCAAATGTTGCTTCTGG 304 1.5 8.3 (SEQ ID No. 148) B 5'-TCATTAGGAAGCTGAACATCAGC (SEQ ID No. 149)exon 32 A 5'-GTTGGAGGAAATTGATCCCAAGTC 351 1.5 8.3 (SEQ ID No. 150) B 5'-TGTTGCTTATGGGTTTAACTTGTG (SEQ ID No. 151)exon 33 A 5'-TAAAGGATTAATGCTGTTAACAGTG 360 1.5 8.3 (SEQ ID No. 152) B 5'-TCACACTGAGCATTTACTACCTG (SEQ ID No. 153)exon 34 C 5'-GCAAAGGAAAATGTAGCACATAGAG 491 1.5 8.3 (SEQ ID No. 154) D 5'-AGGCTATAGGCATTTGAAAGAGG (SEQ ID No. 155)exon 35 A 5'-GTAGGCTCCCAGAAGACCCAG 406 1.5 8.3 (SEQ ID No. 156) B 5'-GAAAGGATGGGTGTGTATTCAGG (SEQ ID No. 157)mutation 7 GD A 5'-ACAGGCCATAGTTTGCCAACCC 426 1.5 9.0 (SEQ ID No. 158) GD D 5'-TGGTATTAGAATTTCCCTTTCTTCC (SEQ ID No. 159)DJG RT-PCR 5EE 5'-TGAAGAGAATATGGAAAGAGGCTTG 2002 1.5 8.3 (SEQ ID No. 160) B. 5'-CTTTATGAAGCCAATTTCTACCC (SEQ ID No. 161)P2934AT1 A 5'-TCAAAATCAGTCGCCTCATCCC 168 2.0 8.3 (SEQ ID No. 162) B 5'-CAATGTATCAGTCAGGGTTCACC (SEQ ID No. 163)__________________________________________________________________________
The annealing temperature was 60.degree. C. for all primer sets.
Mutations are detected by amplifying WRN exons from genomic DNA and directly cycle-sequencing the PCR products by dye-terminator cycle sequencing (Perkin Elmer) and an ABI373 automated DNA sequencer. Prior to sequencing, the PCR-amplified exon fragments were purified using a QIAquick 8 PCR purification kit (Quiagen). The resulting sequences are aligned by FASTA analysis (GCG). Nucleotide differences between WS and controls are subsequently confirmed by sequencing the reverse strand.
Reverse transcriptase PCR (RT-PCR) based methods used to identify some mutations (mutations 1-4 and 9, Table 6) and to confirm the predicted consequences of splice-junction mutations. RT-PCR products were synthesized from mRNA isolated from lymphoblastoid cell lines (Qiagen Oligotex, Qiagen). The large genomic deletion was detected in genomic DNA using long-range PCR (Expand Long Template PCR System, Boehringer Mannheim).
Diagnostic Criteria. WS patients were from an International Registry of Werner's Syndrome subjects. Diagnostic criteria are based on the following signs and symptoms (Nakura et al. 1994). Cardinal signs are: 1) bilateral cataracts; 2) characteristic dermatological pathology (tight skin, atrophic skin, pigmentary alternations, ulceration, hyperkeratosis, regional subcutaneous atrophy) and characteristic facies ("bird" facies); 3) short stature; 4) paternal consanguinity (3rd cousin or greater) or affected sibling; 5) premature greying and/or thinning of scalp hair; 6) positive 24-hour urinary hyaluronic acid test, when available). Further criteria are: 1) diabetes mellitus; 2) hypogonadism (secondary sexual underdevelopment, diminished fertility, testicular or ovarian atrophy); 3) osteoporosis; 4) osteosclerosis of distal phalanges of fingers and/or toes (X-ray diagnosis); 5) soft tissue calcification; 6) evidence of premature atherosclerosis (e.g. history of myocardial infarction); 7) mesenchymal neoplasms, rare neoplasms or multiple neoplasms; 8) voice changes (high pitched, squeaky or hoarse voice); 9) flat feet. Diagnostic classifications are as follows: "Definite", all cardinal signs (#6 when available) and any 2 others; "Probable", the first 3 cardinal signs and any 2 others; "Possible", either cataracts or dermatological alternations and any 4 others; "Excluded", onset of signs and symptoms before adolescence (except short stature since current data on pre-adolescent growth patterns is inadequate) or a negative hyaluronic acid test. Family designations are as previously used (Nakura et al. 1994; Goddard et al. 1996; Yu et al. 1996).
Mutations in WS Subjects. Initial screening of the WRN gene was based on sequence from only the 3' end of the gene (exons 23-35). Thus the first 4 mutations (designated 1-4, Table 3) were in the region 3' to the helicase domains. In this mutation screening, primers amplify exons 2-35 along with approximately 80 bp of flanking intronic sequence (Table 5). Initially, 9 WS subjects (Caucasian subjects DJG, EKL, and FES, and Japanese subjects IB, KO, OW, KUN, WKH, and WSF) were screened for mutations. These subjects were selected based on haplotype analysis that suggested that each subject might have a different mutation (Yu et al. 1994; Goddard et al. 1996). A total of 30 Japanese and 36 Caucasian subjects were ultimately screened for each mutation by DNA sequence analysis of the appropriate exon.
TABLE 6__________________________________________________________________________Summary of WRN Mutations Predicted Type of ProteinMutation Codon Exon Mutation Nucleotide Sequence Comment Length__________________________________________________________________________none 14321 1165 30 substitution CAG (Gln) to TAG nonsense 1164 (terminator)2 1305 33 substitution CGA (Arg) to TGA nonsense 1034 (terminator)3 1230 32 4 bp gtag-ACAG to gt- 4 bp deletion at 1247 deletion AG splice-donor site4 1047- 24 substitution tag-GGT to tac-GGT substitution at 1060 1078 splice-donor site5 369 9 substitution CGA (Arg) to TGA nonsense 368 (terminator)6 889 22 substitution CGA (Arg) to TGA nonsense 888 (terminator)7 759- 20 substitution CAG-gta to CAG-tta substitution at 760 816 splice-receptor site8 389 9 1 bp AGAG (Arg) to frame-shift 391 deletion GAG (Glu)9 697- 19- deletion -- genomic 1186 942 23 (>15 kb) deletion__________________________________________________________________________
TABLE 7__________________________________________________________________________Mutation Status of WS Subjects.sup.1Japanese WS Subjects Non-Japanese WS SubjectsMutation Homozygous Heterozygous Homozygous Heterozygous__________________________________________________________________________1 SY.sup.D2 HH.sup.D, HM.sup.D, MH.sup.M, GAR.sup.D NN.sup.D3 SYR.sup.14 FJ.sup.D, FUW.sup.D, HA.sup.1, HW.sup.D, IU.sup.D, JO1.sup.D, JO2.sup.D, KAKU.sup.P, KY.sup.D, MCI.sup.D, MIE2.sup.1, SK.sup.D, ST.sup.D, TH.sup.1, TK.sup.M, TO.sup.D, ZM.sup.D, 78-85.sup.1.5 KO.sup.D, OW.sup.P KUN.sup.I EKL.sup.D, AG0780.sup.I, DJG.sup.P, CP3.sup.I, NF.sup.M AG4103.sup.M6 CTA.sup.D SUG1.sup.P7 WKH.sup.D8 FES.sup.19 DJG.sup.P, SUG1.sup.P__________________________________________________________________________ .sup.1 The diagnostic classification is as previously described (Nakura e al. 1994). Diagnosis categories: .sup.D Definite; .sup.P Probable; .sup.M Possible; .sup.I Insufficient data. The country of origin (ethnic group) of nonJapanese subjects are: AG00780, USA (Caucasian); AG04103, USA (Caucasian); CTA, England (India, East African, Asian); CP3, France (Caucasian); DJG, Germany (German); #EKL, Switzerland (German); FES, Germany (German); NF, France (Caucasian); SUG, USA (Caucasian); SYR, Syri (Syrian). AG04103 and AG00780 were obtained as cell lines from the Aging Cell Repository (Camden, New Jersey).
Five new WS mutations were detected in the WRN gene (designated 5-9, Table 6). Two of the mutations (5 and 6) were single base substitutions creating nonsense codons. Mutation 5 results in a C.fwdarw.T transition changing an Arg to a termination codon (Table 6, FIG. 6). The predicted protein is truncated at 368 amino acids, excluding the helicase region, which begins at codon 569. Three Japanese and 3 Caucasian subjects were homozygous, and 1 Japanese and 4 Caucasians were heterozygous for this mutation (Table 7). Mutation 6 is also a C.fwdarw.T transition changing an Arg to a nonsense codon. One Caucasian WS subject was homozygous for this mutation, and a second was a compound heterozygote. The predicted protein is 888 amino acids. A third substitution mutation (mutation 7) was a G.fwdarw.T change at a splice-receptor site, generating a truncated mRNA devoid of exon 20 and a prematurely terminated WRN protein at amino acid 760. A single Japanese WS subject was homozygous for this mutation.
Two deletions were observed. One (mutation 8) is a 1 bp deletion at codon 389 resulting in a frame shift and a predicted truncated protein 391 amino acids long. This mutation is found in one Caucasian patient as a heterozygote. The second (mutation 9) is a much larger deletion. This deletion was first observed in RT-PCR experiments when 2 different RT-PCR products were obtained from RNA prepared from subject DJG. RT-PCR products produced by primers 5EE and B (Table 5) yielded 2 different products, one with the expected size of 2009 bp, and a second, shorter product approximately 700 bp smaller. The DNA sequence of the shorter product revealed that exons 19 through 23 were missing. To further establish the nature of this mutation, primers (exons 18A and exon 24A, Table 5) derived from the exons flanking this potential gross deletion (exons 18 and 24) were used to amplify genomic DNA from subject DJG using a long-range PCR protocol. A single 5 kb fragment was observed corresponding to the shorter RT-PCR product. (The normal fragment, which is estimated to be >20 kb was not observed.) The complete DNA sequence of this 5 kb fragment was determined and contained the expected 3' and 5' ends of exons 18 and 24, respectively. The exonic sequences were separated by intronic sequences adjacent to the 3' and 5' end of exons 18 and 24, respectively. No sequences from exons 19-23 were found in the 5 kb fragment. In other subjects and controls, the intronic sequence in the intron 3' to exon 18 contained 531 bp of unique sequence followed by a 241 bp Alu repeat element. Likewise, for the region 5' to exon 24, there is an Alu repeat element separated from exon 24 by 3,460 bp of unique sequence. The 4938 bp fragment from subject DJG contained these unique exon-flanking intronic sequences separated by a single Alu element. Thus, this deletion presumably occurred by a recombination error at 2 highly homologous Alu elements within the WRN gene. A primer set, GD-A and GD-D (Table 5) was designed to specifically amplify a short fragment (426 bp) across this junction point. A single additional Caucasian WS patient, SUG, was shown to contain this genomic deletion. Further PCR amplification of the exons within this deleted region demonstrated that both DJG and SUG are heterozygous for this mutation.
Origins of WRN Mutations. Because multiple subjects have the same mutation and because the same mutation was observed in different ethnic groups, at least some of the mutations likely originated in common founders. Evidence for a common founder was examined using 2 short tandem repeat polymorphisms (STRPs) within the WRN gene. These STRPs, D8S2162 and p2934AT1, were isolated from the same P1 clone (p2934) and are within 17.5 kb of each other. While D8S2162 is not particularly polymorphic (heterozygosity=54% in Japanese and 70% in Caucasians) and is primarily a 2 allele system (140 and 142 bp alleles). p2934AT1 is highly polymorphic (heterozygosity=78% in both Japanese and Caucasian populations). For mutation 4, which has only been observed in Japanese subjects, all but 1 subject had the D8S2164/p2934AT1 haplotype of 140-148 (Table 8). The single exception, JO2, has the haplotype 140-150, with the p2934AT1 allele being 2 bp different from the 148 bp allele observed in other subjects with mutation 4. This 2 bp difference may be the result of a 2 bp mutation, as is commonly observed in dinucleotide repeat STRP lock (Weber and Wong, 1993). The haplotype data is consistent with a common Japanese founder and is consistent with the linkage disequilibrium observed in the same Japanese subjects for other markers in the WRN region (Yu et al. 1994; Goddard et al., 1996). For mutations 2 and 5, in the Japanese, the 896R18-p2934AT1 haplotypes for the small number of available subjects, are consistent with common founds for each mutations. However, the non-Japanese subjects with mutations 2 and 5 have discordant p2934AT1 genotypes when compared to Japanese subjects with the same mutations. These results do not support a common founder for both Japanese and non-Japanese subjects with mutations 2 and 5. Within the non-Japanese subjects, for mutations 5, there may be as many as 3 different founders since in both cases, different subjects with mutation 5 are discordant for p2934AT1 (e.g. compare AG00780 to EKL). It should be noted that absence of evidence for a common founder does not necessarily exclude the possibility of a single originating mutational event. Intragenic recombination and/or mutations creating new alleles at the 2 STRP loci could, over time, obscure the origins of the different WRN mutations.
TABLE 8______________________________________STRP Genotypes at the WRN gene.sup.1.Subject Ethnic Group Mutation y896r18 p2934at1______________________________________FJ, FUW, HA, HW, JO1, Japanese 4 140/140 148/148KAKU, KY, MIE2, TOJO2 Japanese 4 140/140 150/150HM, MH, NN, Japanese 2 140/140 144/144GAR Hispanic 2 140/140 156/156OW, KO Japanese 5 140/140 148/148AG00780 Caucasian 5 142/142 136/136EKL, AG04103 Caucasian 5 142/142 128/128CP3 Caucasian 5/? 142/150 128/142KUN Japanese 5/? 140/142 128/148DJG Caucasian 5/9 140/142 128/del.sup.2______________________________________ .sup.1 Genotype data for HH, SK, TH, TK, and ZM was not available. For y896R18, alleles in bp (frequency for Caucasians, frequency for Japanese) were as follows: 136 (0.030, 0.025); 138 (0.020, 0.010); 140 (0.460, 0.576); 142 (0.337, 0.359); 144 (0.084, 0.010); 146 (0, 0.010); 148 (0.009, 0.010); 150 (0.059, 0). For p2934AT1, alleles in bp (Caucasian frequency, Japanese frequency) were as follows: 114 (0.006, 0); 122 (0, 0.009); 124 (0.011, 0); 128 (0.253, 0.079); 130 (0, 0.018); 132 (0.006, 0.009); #134 (0.046, 0.096); 136 (0.086, 0.009); 138 (0.011, 0); 140 (0.034, 0); 142 (0.052, 0.035); 144 (0.023, 0.061); 146 (0.023, 0.053); 148 (0.034, 0.132); 150 (0.034, 0.105); 152 (0.057, 0.123); 154 (0.063, 0.088); 156 (0.086, 0.070); 158 (0.098, 0.070); 160 (0.046, 0.018); 162 (0.029, 0.009); 166 (0, 0.009); 168 (0, 0.009).
The 5 mutations identified here demonstrate that WS mutations are not restricted to the 3' end of the gene, but are also found in other regions of WRN. In addition, mutations 5 and 7-9 each disrupt either part or all of the helicase region. Thus the WS subjects homozygous for this mutation will completely lack the WRN helicase domains as well as the 3' end of the protein. Though the possibility exists that the truncated 368 amino acid protein has some partial remaining function, mutation 5 probably results in complete loss of all activity of the WRN protein. However, the WS phenotype in these subjects is not appreciably distinct from the WS phenotype generated by the other mutations described here. Thus, all mutations in the WS gene may be complete loss of function mutations.
Example 8
Identification of Mouse WRN Gene
The mouse WRN cDNA was isolated by screening a mouse splenocyte cDNA library at low strengency with human WRN cDNA as probe. The mouse cDNA sequence is presented in FIG. 9. The homology between human and mouse WRN cDNA sequence is about 80%. On the amino acid level, the human and mouse WRN gene product shown about 90% identity. Notably, the repeated exon in human WRN cDNA (exons 10 and 11) is only present once in mouse WRN cDNA.
Genomic mouse WRN clone was isolated by using mouse WRN specific primers to screen mouse genomic BAC library. The genomic DNA sequence is presented in FIG. 6.
The genomic DNA sequence is presented in FIG. 7 and SEQ ID NOS: 207-209. The DNA sequence is presented in FIG. 6 and SEQ ID NOS: 205 and 206.
Example 9
Localization of the WRN Gene Product
A rabbit polyclonal antiserum raised to a peptide of WRN gene product is used in an indirect immunofluorescence assay to determine the intracellular localization of the WRN protein.
A rabbit polyclonal antiserum is raised to the peptide Phe-Pro-Gly-Ser-Glu-Glu-Ile-Cys-Ser-Ser-Ser-Lys-Arg (FPGSEEICSSSKR) (SEQ ID NO: 204) by standard methods (see Harlow and Lane, Antibodies, A. Laboratory Manual, CSH Press, Cold Spring Harbor, 1989; Current Protocols in Immunology, Greene Publishing, 1995). The peptide corresponds to residues 1375 through 1387 of the WRN polypeptide.
Cells, such as epithelial cells, are grown on a plastic or glass surface, fixed with 3% paraformaldehyde and permeabilized for 2 min with a buffer containing 0.5% Triton X-100, 10 mM PIPES, pH 6.8, 50 mM NaCl, 300 mM sucrose, and 3 mM MgCl.sub.2 (see for example, Fey et al., J. Biol. Chem. 98: 1973, 1984). The cells are then stained for 20 min with a suitable dilution of the anti-peptide antibody (1:1500), washed, stained with a suitable second antibody (e.g., FITC-conjugated goat anti-rabbit antibody), washed, and mounted for visualization by gluorescence microscopy. Control stains include bis-benzimidine (Sigma, St. Louis, Mo.), which stains DNA, and phalloidin (Molecular Probes, OR, BODIPY 558/568 phalloidin), which stains filamentous actin.
As seen in FIG. 9, the WRN gene product is almost entirely located in the nucleus. Nuclear staining is readily noted in the epithelial cells at the bottom left in panel A. These cells are close to the periphery of the expanding clone of human prostate epithelial cells. Cells that are not rapidly dividing (e.g., cells closer to the center of the clone), such as those seen in the upper right of panel A, are stained in both the cytoplasm and nucleus. The location and size of the nuclei in these cells is shown by staining DNA with the intercalating dye bis-benzimidine (Hoeschst 33258), panel B. The overall size of the cells and in some cases key cytoskeletal features are revealed by staining for F-actin as shown in panel C.
Example 10
Isolation of a Protein That Binds to the WRN Gene Product
A yeast 2-hybrid interaction screen (Hollenberg et al., Mol. Cell Biol. 13: 3813, 1995) is used to identify and isolate a cellular protein that binds to the carboxy-terminal 443 amino acids (residues 990 through 1432) of the WRN gene product.
A library of 1.1.times.106 independent cDNA clones generated from RNA isolated from stimulated human peripheral blood mononuclear cells is generated in pACT-2 (Clontech, Palo Alto, Calif.) that creates cDNA/GAL4 activation domain fusions is co-transfected into yeast containing pLEXA with the WRN gene fragment to generate WRN/LEXA DNA-binding fusion. Host yeast cells, L40, are grown on medium lacking leucine, tryptophan, and histidine and containing 4 mM 3 AT, a toxic catabolite for histidine. 67 colonies grew on this medium. Of these, 60 were cured of the pLEXA plasmid by growth on medium containing cycloheximide and mated with a yeast strain expressing a fusion of a "sticky" laminin and the GAL4 activation domain. 19 clones did not activate the sticky protein and underwent DNA sequence analysis. Of these, 6 contained sequences that did not match any sequence in GenBank by BLAST search. Two other clones encoded carnitine palmitoyl transferase I and prolyl 4-hydroxylase B subunit. Six independent clones encoded a 70K component of the U1 snRNP complex (GenBank Accession No. M22636). Moreover, all six derived from the RNA recognition motif region of the 70K protein.
From the foregoing, it will be appreciated that, although specific embodiments of this invention have been described herein for the purposes of illustration, various modifications may be made without departing from the spirit and scope of the invention. Accordingly, the invention is not limited except by the appended claims.
__________________________________________________________________________# SEQUENCE LISTING- (1) GENERAL INFORMATION:- (iii) NUMBER OF SEQUENCES: 209- (2) INFORMATION FOR SEQ ID NO:1:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1:# 22GAG AG- (2) INFORMATION FOR SEQ ID NO:2:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2:# 23TCTA CCC- (2) INFORMATION FOR SEQ ID NO:3:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3:# 22CTA GG- (2) INFORMATION FOR SEQ ID NO:4:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4:# 26 TTAC ATTTAC- (2) INFORMATION FOR SEQ ID NO:5:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5:# 22ATG AG- (2) INFORMATION FOR SEQ ID NO:6:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6:# 26 GAAA GCATAG- (2) INFORMATION FOR SEQ ID NO:7:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 21 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7:#21 ACTG C- (2) INFORMATION FOR SEQ ID NO:8:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 21 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8:#21 AGAC C- (2) INFORMATION FOR SEQ ID NO:9:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9:# 22GTT GC- (2) INFORMATION FOR SEQ ID NO:10:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10:# 22TCT CC- (2) INFORMATION FOR SEQ ID NO:11:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11:# 22ATA GC- (2) INFORMATION FOR SEQ ID NO:12:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12:# 24CAAA ATGC- (2) INFORMATION FOR SEQ ID NO:13:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13:# 23CATA CTC- (2) INFORMATION FOR SEQ ID NO:14:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14:# 22CAT GC- (2) INFORMATION FOR SEQ ID NO:15:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15:# 24TGGA GAAG- (2) INFORMATION FOR SEQ ID NO:16:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16:# 23ATGA TAC- (2) INFORMATION FOR SEQ ID NO:17:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17:# 23CAGC AAG- (2) INFORMATION FOR SEQ ID NO:18:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18:# 24TGTT CTGG- (2) INFORMATION FOR SEQ ID NO:19:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19:# 23CACG ACC- (2) INFORMATION FOR SEQ ID NO:20:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20:# 24CATT CGCC- (2) INFORMATION FOR SEQ ID NO:21:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21:# 24AGGA CATG- (2) INFORMATION FOR SEQ ID NO:22:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:# 25 GAGT AGAAG- (2) INFORMATION FOR SEQ ID NO:23:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23:# 25 AAGA GCTTG- (2) INFORMATION FOR SEQ ID NO:24:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24:# 25 CTAA ATGCT- (2) INFORMATION FOR SEQ ID NO:25:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25:# 23TTGC GCA- (2) INFORMATION FOR SEQ ID NO:26:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26:# 22AAG TC- (2) INFORMATION FOR SEQ ID NO:27:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27:# 23AGGA CAC- (2) INFORMATION FOR SEQ ID NO:28:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 21 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28:#21 CATC C- (2) INFORMATION FOR SEQ ID NO:29:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29:# 23TCAT CAC- (2) INFORMATION FOR SEQ ID NO:30:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30:# 23TGGG AGG- (2) INFORMATION FOR SEQ ID NO:31:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31:# 24GTGG ATGG- (2) INFORMATION FOR SEQ ID NO:32:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32:# 24TTTC TACC- (2) INFORMATION FOR SEQ ID NO:33:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:# 25 AGAC AAGTC- (2) INFORMATION FOR SEQ ID NO:34:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34:# 22CTG AG- (2) INFORMATION FOR SEQ ID NO:35:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35:# 22ATG GG- (2) INFORMATION FOR SEQ ID NO:36:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36:# 23AAAC TGG- (2) INFORMATION FOR SEQ ID NO:37:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37:# 22TCT GC- (2) INFORMATION FOR SEQ ID NO:38:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38:# 25 TTGG AAAGG- (2) INFORMATION FOR SEQ ID NO:39:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39:# 25 TGAG AATGG- (2) INFORMATION FOR SEQ ID NO:40:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40:# 23CTGA CAG- (2) INFORMATION FOR SEQ ID NO:41:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41:# 25 TGAT TAGGC- (2) INFORMATION FOR SEQ ID NO:42:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42:# 25 ACTC TTAGC- (2) INFORMATION FOR SEQ ID NO:43:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:# 24ACAT TCTC- (2) INFORMATION FOR SEQ ID NO:44:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44:# 22TAT GG- (2) INFORMATION FOR SEQ ID NO:45:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45:# 24TGAA GCTC- (2) INFORMATION FOR SEQ ID NO:46:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46:# 23CTTC TGG- (2) INFORMATION FOR SEQ ID NO:47:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47:# 23CATC AGC- (2) INFORMATION FOR SEQ ID NO:48:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48:# 24CCCA AGTC- (2) INFORMATION FOR SEQ ID NO:49:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49:# 24AACT TGTG- (2) INFORMATION FOR SEQ ID NO:50:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50:# 25 TTAA CAGTG- (2) INFORMATION FOR SEQ ID NO:51:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51:# 23CTAC CTG- (2) INFORMATION FOR SEQ ID NO:52:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52:# 25 TCAT AACAG- (2) INFORMATION FOR SEQ ID NO:53:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53:# 22CTT CC- (2) INFORMATION FOR SEQ ID NO:54:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54:# 24ACAT AGAG- (2) INFORMATION FOR SEQ ID NO:55:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:55:# 23AAAG AGG- (2) INFORMATION FOR SEQ ID NO:56:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 21 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56:#21 CCCA G- (2) INFORMATION FOR SEQ ID NO:57:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57:# 23ATTC AGG- (2) INFORMATION FOR SEQ ID NO:58:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 17 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58:# 17 A- (2) INFORMATION FOR SEQ ID NO:59:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 17 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59:# 17 A- (2) INFORMATION FOR SEQ ID NO:60:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 18 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:60:# 18 AT- (2) INFORMATION FOR SEQ ID NO:61:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 18 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61:# 18 AT- (2) INFORMATION FOR SEQ ID NO:62:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 12 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62:# 12- (2) INFORMATION FOR SEQ ID NO:63:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 12 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63:# 12- (2) INFORMATION FOR SEQ ID NO:64:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 15 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64:# 15- (2) INFORMATION FOR SEQ ID NO:65:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 15 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:65:# 15- (2) INFORMATION FOR SEQ ID NO:66:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 12 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66:# 12- (2) INFORMATION FOR SEQ ID NO:67:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 12 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67:# 12- (2) INFORMATION FOR SEQ ID NO:68:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 17 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68:# 17 C- (2) INFORMATION FOR SEQ ID NO:69:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 13 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69:# 13- (2) INFORMATION FOR SEQ ID NO:70:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 5208 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:70:- TGTGCGCCGG GGAGGCGCCG GCTTGTACTC GGCAGCGCGG GAATAAAGTT TG - #CTGATTTG 60- GTGTCTAGCC TGGATGCCTG GGTTGCAGCC CTGCTTGTGG TGGCGCTCCA CA - #GTCATCCG 120- GCTGAAGAAG ACCTGTTGGA CTGGATCTTC TCGGGTTTTC TTTCAGATAT TG - #TTTTGTAT 180- TTACCCATGA AGACATTGTT TTTTGGACTC TGCAAATAGG ACATTTCAAA GA - #TGAGTGAA 240- AAAAAATTGG AAACAACTGC ACAGCAGCGG AAATGTCCTG AATGGATGAA TG - #TGCAGAAT 300- AAAAGATGTG CTGTAGAAGA AAGAAAGGCA TGTGTTCGGA AGAGTGTTTT TG - #AAGATGAC 360- CTCCCCTTCT TAGAATTCAC TGGATCCATT GTGTATAGTT ACGATGCTAG TG - #ATTGCTCT 420- TTCCTGTCAG AAGATATTAG CATGAGTCTA TCAGATGGGG ATGTGGTGGG AT - #TTGACATG 480- GAGTGGCCAC CATTATACAA TAGAGGGAAA CTTGGCAAAG TTGCACTAAT TC - #AGTTGTGT 540- GTTTCTGAGA GCAAATGTTA CTTGTTCCAC GTTTCTTCCA TGTCAGTTTT TC - #CCCAGGGA 600- TTAAAAATGT TGCTTGAAAA TAAAGCAGTT AAAAAGGCAG GTGTAGGAAT TG - #AAGGAGAT 660- CAGTGGAAAC TTCTACGTGA CTTTGATATC AAATTGAAGA ATTTTGTGGA GT - #TGACAGAT 720- GTTGCCAATA AAAAGCTGAA ATGTACAGAG ACCTGGAGCC TTAACAGTCT GG - #TTAAACAC 780- CTCTTAGGTA AACAGCTCCT GAAAGACAAG TCTATCCGCT GTAGCAATTG GA - #GTAAATTT 840- CCTCTCACTG AGGACCAGAA ACTGTATGCA GCCACTGATG CTTATGCTGG TT - #TTATTATT 900- TACCGAAATT TAGAGATTTT GGATGATACT GTGCAAAGGT TTGCTATAAA TA - #AAGAGGAA 960- GAAATCCTAC TTAGCGACAT GAACAAACAG TTGACTTCAA TCTCTGAGGA AG - #TGATGGAT1020- CTGGCTAAGC ATCTTCCTCA TGCTTTCAGT AAATTGGAAA ACCCACGGAG GG - #TTTCTATC1080- TTACTAAAGG ATATTTCAGA AAATCTATAT TCACTGAGGA GGATGATAAT TG - #GGTCTACT1140- AACATTGAGA CTGAACTGAG GCCCAGCAAT AATTTAAACT TATTATCCTT TG - #AAGATTCA1200- ACTACTGGGG GAGTACAACA GAAACAAATT AGAGAACATG AAGTTTTAAT TC - #ACGTTGAA1260- GATGAAACAT GGGACCCAAC ACTTGATCAT TTAGCTAAAC ATGATGGAGA AG - #ATGTACTT1320- GGAAATAAAG TGGAACGAAA AGAAGATGGA TTTGAAGATG GAGTAGAAGA CA - #ACAAATTG1380- AAAGAGAATA TGGAAAGAGC TTGTTTGATG TCGTTAGATA TTACAGAACA TG - #AACTCCAA1440- ATTTTGGAAC AGCAGTCTCA GGAAGAATAT CTTAGTGATA TTGCTTATAA AT - #CTACTGAG1500- CATTTATCTC CCAATGATAA TGAAAACGAT ACGTCCTATG TAATTGAGAG TG - #ATGAAGAT1560- TTAGAAATGG AGATGCTTAA GCATTTATCT CCCAATGATA ATGAAAACGA TA - #CGTCCTAT1620- GTAATTGAGA GTGATGAAGA TTTAGAAATG GAGATGCTTA AGTCTTTAGA AA - #ACCTCAAT1680- AGTGGCACGG TAGAACCAAC TCATTCTAAA TGCTTAAAAA TGGAAAGAAA TC - #TGGGTCTT1740- CCTACTAAAG AAGAAGAAGA AGATGATGAA AATGAAGCTA ATGAAGGGGA AG - #AAGATGAT1800- GATAAGGACT TTTTGTGGCC AGCACCCAAT GAAGAGCAAG TTACTTGCCT CA - #AGATGTAC1860- TTTGGCCATT CCAGTTTTAA ACCAGTTCAG TGGAAAGTGA TTCATTCAGT AT - #TAGAAGAA1920- AGAAGAGATA ATGTTGCTGT CATGGCAACT GGATATGGAA AGAGTTTGTG CT - #TCCAGTAT1980- CCACCTGTTT ATGTAGGCAA GATTGGCCTT GTTATCTCTC CCCTTATTTC TC - #TGATGGAA2040- GACCAAGTGC TACAGCTTAA AATGTCCAAC ATCCCAGCTT GCTTCCTTGG AT - #CAGCACAG2100- TCAGAAAATG TTCTAACAGA TATTAAATTA GGTAAATACC GGATTGTATA CG - #TAACTCCA2160- GAATACTGTT CAGGTAACAT GGGCCTGCTC CAGCAACTTG AGGCTGATAT TG - #GTATCACG2220- CTCATTGCTG TGGATGAGGC TCACTGTATT TCTGAGTGGG GGCATGATTT TA - #GGGATTCA2280- TTCAGGAAGT TGGGCTCCCT AAAGACAGCA CTGCCAATGG TTCCAATCGT TG - #CACTTACT2340- GCTACTGCAA GTTCTTCAAT CCGGGAAGAC ATTGTACGTT GCTTAAATCT GA - #GAAATCCT2400- CAGATCACCT GTACTGGTTT TGATCGACCA AACCTGTATT TAGAAGTTAG GC - #GAAAAACA2460- GGGAATATCC TTCAGGATCT GCAGCCATTT CTTGTCAAAA CAAGTTCCCA CT - #GGGAATTT2520- GAAGGTCCAA CAATCATCTA CTGTCCTTCT AGAAAAATGA CACAACAAGT TA - #CAGGTGAA2580- CTTAGGAAAC TTAATCTATC CTGTGGAACA TACCATGCGG GCATGAGTTT TA - #GCACAAGG2640- AAAGACATTC ATCATAGGTT TGTAAGAGAT GAAATTCAGT GTGTCATAGC TA - #CCATAGCT2700- TTTGGAATGG GCATTAATAA AGCTGACATT CGCCAAGTCA TTCATTACGG TG - #CTCCTAAG2760- GACATGGAAT CATATTATCA GGAGATTGGT AGAGCTGGTC GTGATGGACT TC - #AAAGTTCT2820- TGTCACGTCC TCTGGGCTCC TGCAGACATT AACTTAAATA GGCACCTTCT TA - #CTGAGATA2880- CGTAATGAGA AGTTTCGATT ATACAAATTA AAGATGATGG CAAAGATGGA AA - #AATATCTT2940- CATTCTAGCA GATGTAGGAG ACAAATCATC TTGTCTCATT TTGAGGACAA AC - #AAGTACAA3000- AAAGCCTCCT TGGGAATTAT GGGAACTGAA AAATGCTGTG ATAATTGCAG GT - #CCAGATTG3060- GATCATTGCT ATTCCATGGA TGACTCAGAG GATACATCCT GGGACTTTGG TC - #CACAAGCA3120- TTTAAGCTTT TGTCTGCTGT GGACATCTTA GGCGAAAAAT TTGGAATTGG GC - #TTCCAATT3180- TTATTTCTCC GAGGATCTAA TTCTCAGCGT CTTGCCGATC AATATCGCAG GC - #ACAGTTTA3240- TTTGGCACTG GCAAGGATCA AACAGAGAGT TGGTGGAAGG CTTTTTCCCG TC - #AGCTGATC3300- ACTGAGGGAT TCTTGGTAGA AGTTTCTCGG TATAACAAAT TTATGAAGAT TT - #GCGCCCTT3360- ACGAAAAAGG GTAGAAATTG GCTTCATAAA GCTAATACAG AATCTCAGAG CC - #TCATCCTT3420- CAAGCTAATG AAGAATTGTG TCCAAAGAAG TTTCTTCTGC CTAGTTCGAA AA - #CTGTATCT3480- TCGGGCACCA AAGAGCATTG TTATAATCAA GTACCAGTTG AATTAAGTAC AG - #AGAAGAAG3540- TCTAACTTGG AGAAGTTATA TTCTTATAAA CCATGTGATA AGATTTCTTC TG - #GGAGTAAC3600- ATTTCTAAAA AAAGTATCAT GGTACAGTCA CCAGAAAAAG CTTACAGTTC CT - #CACAGCCT3660- GTTATTTCGG CACAAGAGCA GGAGACTCAG ATTGTGTTAT ATGGCAAATT GG - #TAGAAGCT3720- AGGCAGAAAC ATGCCAATAA AATGGATGTT CCCCCAGCTA TTCTGGCAAC AA - #ACAAGATA3780- CTGGTGGATA TGGCCAAAAT GAGACCAACT ACGGTTGAAA ACGTAAAAAG GA - #TTGATGGT3840- GTTTCTGAAG GCAAAGCTGC CATGTTGGCC CCTCTGTTGG AAGTCATCAA AC - #ATTTCTGC3900- CAAACAAATA GTGTTCAGAC AGACCTCTTT TCAAGTACAA AACCTCAAGA AG - #AACAGAAG3960- ACGAGTCTGG TAGCAAAAAA TAAAATATGC ACACTTTCAC AGTCTATGGC CA - #TCACATAC4020- TCTTTATTCC AAGAAAAGAA GATGCCTTTG AAGAGCATAG CTGAGAGCAG GA - #TTCTGCCT4080- CTCATGACAA TTGGCATGCA CTTATCCCAA GCGGTGAAAG CTGGCTGCCC CC - #TTGATTTG4140- GAGCGAGCAG GCCTGACTCC AGAGGTTCAG AAGATTATTG CTGATGTTAT CC - #GAAACCCT4200- CCCGTCAACT CAGATATGAG TAAAATTAGC CTAATCAGAA TGTTAGTTCC TG - #AAAACATT4260- GACACGTACC TTATCCACAT GGCAATTGAG ATCCTTAAAC ATGGTCCTGA CA - #GCGGACTT4320- CAACCTTCAT GTGATGTCAA CAAAAGGAGA TGTTTTCCCG GTTCTGAAGA GA - #TCTGTTCA4380- AGTTCTAAGA GAAGCAAGGA AGAAGTAGGC ATCAATACTG AGACTTCATC TG - #CAGAGAGA4440- AAGAGACGAT TACCTGTGTG GTTTGCCAAA GGAAGTGATA CCAGCAAGAA AT - #TAATGGAC4500- AAAACGAAAA GGGGAGGTCT TTTTAGTTAA GCTGGCAATT ACCAGAACAA TT - #ATGTTTCT4560- TGCTGTATTA TAAGAGGATA GCTATATTTT ATTTCTGAAG AGTAAGGAGT AG - #TATTTTGG4620- CTTAAAAATC ATTCTAATTA CAAAGTTCAC TGTTTATTGA AGAACTGGCA TC - #TTAAATCA4680- GCCTTCCGCA ATTCATGTAG TTTCTGGGTC TTCTGGGAGC CTACGTGAGT AC - #ATCACCTA4740- ACAGAATATT AAATTAGACT TCCTGTAAGA TTGCTTTAAG AAACTGTTAC TG - #TCCTGTTT4800- TCTAATCTCT TTATTAAAAC AGTGTATTTG GAAAATGTTA TGTGCTCTGA TT - #TGATATAG4860- ATAACAGATT AGTAGTTACA TGGTAATTAT GTGATATAAA ATATTCATAT AT - #TATCAAAA4920- TTCTGTTTTG TAAATGTAAG AAAGCATAGT TATTTTACAA ATTGTTTTTA CT - #GTCTTTTG4980- AAGAAGTTCT TAAATACGTT GTTAAATGGT ATTAGTTGAC CAGGGCAGTG AA - #AATGAAAC5040- CGCATTTTGG GTGCCATTAA ATAGGGAAAA AACATGTAAA AAATGTAAAA TG - #GAGACCAA5100- TTGCACTAGG CAAGTGTATA TTTTGTATTT TATATACAAT TTCTATTATT TT - #TCAAGTAA5160# 5208ATAC TGAATATTAA AAAAAAAAAA AAAAAAAA- (2) INFORMATION FOR SEQ ID NO:71:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 1432 amino (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:71:- Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gl - #n Gln Arg Lys Cys Pro# 15- Glu Trp Met Asn Val Gln Asn Lys Arg Cys Al - #a Val Glu Glu Arg Lys# 30- Ala Cys Val Arg Lys Ser Val Phe Glu Asp As - #p Leu Pro Phe Leu Glu# 45- Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Al - #a Ser Asp Cys Ser Phe# 60- Leu Ser Glu Asp Ile Ser Met Ser Leu Ser As - #p Gly Asp Val Val Gly#80- Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Ar - #g Gly Lys Leu Gly Lys# 95- Val Ala Leu Ile Gln Leu Cys Val Ser Glu Se - #r Lys Cys Tyr Leu Phe# 110- His Val Ser Ser Met Ser Val Phe Pro Gln Gl - #y Leu Lys Met Leu Leu# 125- Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gl - #y Ile Glu Gly Asp Gln# 140- Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Le - #u Lys Asn Phe Val Glu145 1 - #50 1 - #55 1 -#60- Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cy - #s Thr Glu Thr Trp Ser# 175- Leu Asn Ser Leu Val Lys His Leu Leu Gly Ly - #s Gln Leu Leu Lys Asp# 190- Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Ph - #e Pro Leu Thr Glu Asp# 205- Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Al - #a Gly Phe Ile Ile Tyr# 220- Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gl - #n Arg Phe Ala Ile Asn225 2 - #30 2 - #35 2 -#40- Lys Glu Glu Glu Ile Leu Leu Ser Asp Met As - #n Lys Gln Leu Thr Ser# 255- Ile Ser Glu Glu Val Met Asp Leu Ala Lys Hi - #s Leu Pro His Ala Phe# 270- Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Il - #e Leu Leu Lys Asp Ile# 285- Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Il - #e Ile Gly Ser Thr Asn# 300- Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Le - #u Asn Leu Leu Ser Phe305 3 - #10 3 - #15 3 -#20- Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Ly - #s Gln Ile Arg Glu His# 335- Glu Val Leu Ile His Val Glu Asp Glu Thr Tr - #p Asp Pro Thr Leu Asp# 350- His Leu Ala Lys His Asp Gly Glu Asp Val Le - #u Gly Asn Lys Val Glu# 365- Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Gl - #u Asp Asn Lys Leu Lys# 380- Glu Asn Met Glu Arg Ala Cys Leu Met Ser Le - #u Asp Ile Thr Glu His385 3 - #90 3 - #95 4 -#00- Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Gl - #u Glu Tyr Leu Ser Asp# 415- Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pr - #o Asn Asp Asn Glu Asn# 430- Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu As - #p Leu Glu Met Glu Met# 445- Leu Lys His Leu Ser Pro Asn Asp Asn Glu As - #n Asp Thr Ser Tyr Val# 460- Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Me - #t Leu Lys Ser Leu Glu465 4 - #70 4 - #75 4 -#80- Asn Leu Asn Ser Gly Thr Val Glu Pro Thr Hi - #s Ser Lys Cys Leu Lys# 495- Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Gl - #u Glu Glu Glu Asp Asp# 510- Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp As - #p Asp Lys Asp Phe Leu# 525- Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cy - #s Leu Lys Met Tyr Phe# 540- Gly His Ser Ser Phe Lys Pro Val Gln Trp Ly - #s Val Ile His Ser Val545 5 - #50 5 - #55 5 -#60- Leu Glu Glu Arg Arg Asp Asn Val Ala Val Me - #t Ala Thr Gly Tyr Gly# 575- Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Ty - #r Val Gly Lys Ile Gly# 590- Leu Val Ile Ser Pro Leu Ile Ser Leu Met Gl - #u Asp Gln Val Leu Gln# 605- Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Le - #u Gly Ser Ala Gln Ser# 620- Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Ly - #s Tyr Arg Ile Val Tyr625 6 - #30 6 - #35 6 -#40- Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gl - #y Leu Leu Gln Gln Leu# 655- Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Va - #l Asp Glu Ala His Cys# 670- Ile Ser Glu Trp Gly His Asp Phe Arg Asp Se - #r Phe Arg Lys Leu Gly# 685- Ser Leu Lys Thr Ala Leu Pro Met Val Pro Il - #e Val Ala Leu Thr Ala# 700- Thr Ala Ser Ser Ser Ile Arg Glu Asp Ile Va - #l Arg Cys Leu Asn Leu705 7 - #10 7 - #15 7 -#20- Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe As - #p Arg Pro Asn Leu Tyr# 735- Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Le - #u Gln Asp Leu Gln Pro# 750- Phe Leu Val Lys Thr Ser Ser His Trp Glu Ph - #e Glu Gly Pro Thr Ile# 765- Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gl - #n Val Thr Gly Glu Leu# 780- Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr Hi - #s Ala Gly Met Ser Phe785 7 - #90 7 - #95 8 -#00- Ser Thr Arg Lys Asp Ile His His Arg Phe Va - #l Arg Asp Glu Ile Gln# 815- Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gl - #y Ile Asn Lys Ala Asp# 830- Ile Arg Gln Val Ile His Tyr Gly Ala Pro Ly - #s Asp Met Glu Ser Tyr# 845- Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gl - #y Leu Gln Ser Ser Cys# 860- His Val Leu Trp Ala Pro Ala Asp Ile Asn Le - #u Asn Arg His Leu Leu865 8 - #70 8 - #75 8 -#80- Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Ty - #r Lys Leu Lys Met Met# 895- Ala Lys Met Glu Lys Tyr Leu His Ser Ser Ar - #g Cys Arg Arg Gln Ile# 910- Ile Leu Ser His Phe Glu Asp Lys Gln Val Gl - #n Lys Ala Ser Leu Gly# 925- Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cy - #s Arg Ser Arg Leu Asp# 940- His Cys Tyr Ser Met Asp Asp Ser Glu Asp Th - #r Ser Trp Asp Phe Gly945 9 - #50 9 - #55 9 -#60- Pro Gln Ala Phe Lys Leu Leu Ser Ala Val As - #p Ile Leu Gly Glu Lys# 975- Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Ar - #g Gly Ser Asn Ser Gln# 990- Arg Leu Ala Asp Gln Tyr Arg Arg His Ser Le - #u Phe Gly Thr Gly Lys# 10050- Asp Gln Thr Glu Ser Trp Trp Lys Ala Phe Se - #r Arg Gln Leu Ile Thr# 10205- Glu Gly Phe Leu Val Glu Val Ser Arg Tyr As - #n Lys Phe Met Lys Ile# 10401030 - # 1035- Cys Ala Leu Thr Lys Lys Gly Arg Asn Trp Le - #u His Lys Ala Asn Thr# 10550- Glu Ser Gln Ser Leu Ile Leu Gln Ala Asn Gl - #u Glu Leu Cys Pro Lys# 10705- Lys Phe Leu Leu Pro Ser Ser Lys Thr Val Se - #r Ser Gly Thr Lys Glu# 10850- His Cys Tyr Asn Gln Val Pro Val Glu Leu Se - #r Thr Glu Lys Lys Ser# 11005- Asn Leu Glu Lys Leu Tyr Ser Tyr Lys Pro Cy - #s Asp Lys Ile Ser Ser# 11201110 - # 1115- Gly Ser Asn Ile Ser Lys Lys Ser Ile Met Va - #l Gln Ser Pro Glu Lys# 11350- Ala Tyr Ser Ser Ser Gln Pro Val Ile Ser Al - #a Gln Glu Gln Glu Thr# 11505- Gln Ile Val Leu Tyr Gly Lys Leu Val Glu Al - #a Arg Gln Lys His Ala# 11650- Asn Lys Met Asp Val Pro Pro Ala Ile Leu Al - #a Thr Asn Lys Ile Leu# 11805- Val Asp Met Ala Lys Met Arg Pro Thr Thr Va - #l Glu Asn Val Lys Arg# 12001190 - # 1195- Ile Asp Gly Val Ser Glu Gly Lys Ala Ala Me - #t Leu Ala Pro Leu Leu# 12150- Glu Val Ile Lys His Phe Cys Gln Thr Asn Se - #r Val Gln Thr Asp Leu# 12305- Phe Ser Ser Thr Lys Pro Gln Glu Glu Gln Ly - #s Thr Ser Leu Val Ala# 12450- Lys Asn Lys Ile Cys Thr Leu Ser Gln Ser Me - #t Ala Ile Thr Tyr Ser# 12605- Leu Phe Gln Glu Lys Lys Met Pro Leu Lys Se - #r Ile Ala Glu Ser Arg# 12801270 - # 1275- Ile Leu Pro Leu Met Thr Ile Gly Met His Le - #u Ser Gln Ala Val Lys# 12950- Ala Gly Cys Pro Leu Asp Leu Glu Arg Ala Gl - #y Leu Thr Pro Glu Val# 13105- Gln Lys Ile Ile Ala Asp Val Ile Arg Asn Pr - #o Pro Val Asn Ser Asp# 13250- Met Ser Lys Ile Ser Leu Ile Arg Met Leu Va - #l Pro Glu Asn Ile Asp# 13405- Thr Tyr Leu Ile His Met Ala Ile Glu Ile Le - #u Lys His Gly Pro Asp# 13601350 - # 1355- Ser Gly Leu Gln Pro Ser Cys Asp Val Asn Ly - #s Arg Arg Cys Phe Pro# 13750- Gly Ser Glu Glu Ile Cys Ser Ser Ser Lys Ar - #g Ser Lys Glu Glu Val# 13905- Gly Ile Asn Thr Glu Thr Ser Ser Ala Glu Ar - #g Lys Arg Arg Leu Pro# 14050- Val Trp Phe Ala Lys Gly Ser Asp Thr Ser Ly - #s Lys Leu Met Asp Lys# 14205- Thr Lys Arg Gly Gly Leu Phe Ser1425 1430- (2) INFORMATION FOR SEQ ID NO:72:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 2178 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 313..1497- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:72:- TTTGGAATTG GGCTTCCAAT TTTATTTCTC CGAGGATCTG GTCTCACTCT GT - #TGCTCAGT 60- CTGTAGTGCA GTGGTGTCAT CATAGCTCAC TGCAGTCTTG ATCTCCTGAG CT - #CAAACGAT 120- TCTCCTGCCT CAGCTCCTGC TTCAGCCTCC TGAGTAGCGG AACAACAGAA TT - #CTCAGCGT 180- CTTGCCGATC AATATCGCAG GCACAGTTTA TTTGGCACTG GCAAGGATCA AA - #CAGAGAGT 240- TGGTGGAAGG CTTTTTCCCG TCAGCTGATC ACTGAGGGAT TCTTGGTAGA AG - #TTTCTCGG 300- TATAACAAAT TT ATG AAG ATT TGC GCC CTT ACG AAA - # AAG GGT AGA AAT 348 Met Lys Il - #e Cys Ala Leu Thr Lys Lys Gly Arg Asn# 10705- TGG CTT CAT AAA GCT AAT ACA GAA TCT CAG AG - #C CTC ATC CTT CAA GCT 396Trp Leu His Lys Ala Asn Thr Glu Ser Gln Se - #r Leu Ile Leu Gln Ala# 10901080 - # 1085- AAT GAA GAA TTG TGT CCA AAG AAG TTT CTT CT - #G CCT AGT TCG AAA ACT 444Asn Glu Glu Leu Cys Pro Lys Lys Phe Leu Le - #u Pro Ser Ser Lys Thr# 11050- GTA TCT TCG GGC ACC AAA GAG CAT TGT TAT AA - #T CAA GTA CCA GTT GAA 492Val Ser Ser Gly Thr Lys Glu His Cys Tyr As - #n Gln Val Pro Val Glu# 11205- TTA AGT ACA GAG AAG AAG TCT AAC TTG GAG AA - #G TTA TAT TCT TAT AAA 540Leu Ser Thr Glu Lys Lys Ser Asn Leu Glu Ly - #s Leu Tyr Ser Tyr Lys# 11350- CCA TGT GAT AAG ATT TCT TCT GGG AGT AAC AT - #T TCT AAA AAA AGT ATC 588Pro Cys Asp Lys Ile Ser Ser Gly Ser Asn Il - #e Ser Lys Lys Ser Ile# 11505- ATG GTA CAG TCA CCA GAA AAA GCT TAC AGT TC - #C TCA CAG CCT GTT ATT 636Met Val Gln Ser Pro Glu Lys Ala Tyr Ser Se - #r Ser Gln Pro Val Ile# 11701160 - # 1165- TCG GCA CAA GAG CAG GAG ACT CAG ATT GTG TT - #A TAT GGC AAA TTG GTA 684Ser Ala Gln Glu Gln Glu Thr Gln Ile Val Le - #u Tyr Gly Lys Leu Val# 11850- GAA GCT AGG CAG AAA CAT GCC AAT AAA ATG GA - #T GTT CCC CCA GCT ATT 732Glu Ala Arg Gln Lys His Ala Asn Lys Met As - #p Val Pro Pro Ala Ile# 12005- CTG GCA ACA AAC AAG ATA CTG GTG GAT ATG GC - #C AAA ATG AGA CCA ACT 780Leu Ala Thr Asn Lys Ile Leu Val Asp Met Al - #a Lys Met Arg Pro Thr# 12150- ACG GTT GAA AAC GTA AAA AGG ATT GAT GGT GT - #T TCT GAA GGC AAA GCT 828Thr Val Glu Asn Val Lys Arg Ile Asp Gly Va - #l Ser Glu Gly Lys Ala# 12305- GCC ATG TTG GCC CCT CTG TTG GAA GTC ATC AA - #A CAT TTC TGC CAA ACA 876Ala Met Leu Ala Pro Leu Leu Glu Val Ile Ly - #s His Phe Cys Gln Thr# 12501240 - # 1245- AAT AGT GTT CAG ACA GAC CTC TTT TCA AGT AC - #A AAA CCT CAA GAA GAA 924Asn Ser Val Gln Thr Asp Leu Phe Ser Ser Th - #r Lys Pro Gln Glu Glu# 12650- CAG AAG ACG AGT CTG GTA GCA AAA AAT AAA AT - #A TGC ACA CTT TCA CAG 972Gln Lys Thr Ser Leu Val Ala Lys Asn Lys Il - #e Cys Thr Leu Ser Gln# 12805- TCT ATG GCC ATC ACA TAC TCT TTA TTC CAA GA - #A AAG AAG ATG CCT TTG1020Ser Met Ala Ile Thr Tyr Ser Leu Phe Gln Gl - #u Lys Lys Met Pro Leu# 12950- AAG AGC ATA GCT GAG AGC AGG ATT CTG CCT CT - #C ATG ACA ATT GGC ATG1068Lys Ser Ile Ala Glu Ser Arg Ile Leu Pro Le - #u Met Thr Ile Gly Met# 13105- CAC TTA TCC CAA GCG GTG AAA GCT GGC TGC CC - #C CTT GAT TTG GAG CGA1116His Leu Ser Gln Ala Val Lys Ala Gly Cys Pr - #o Leu Asp Leu Glu Arg# 13301320 - # 1325- GCA GGC CTG ACT CCA GAG GTT CAG AAG ATT AT - #T GCT GAT GTT ATC CGA1164Ala Gly Leu Thr Pro Glu Val Gln Lys Ile Il - #e Ala Asp Val Ile Arg# 13450- AAC CCT CCC GTC AAC TCA GAT ATG AGT AAA AT - #T AGC CTA ATC AGA ATG1212Asn Pro Pro Val Asn Ser Asp Met Ser Lys Il - #e Ser Leu Ile Arg Met# 13605- TTA GTT CCT GAA AAC ATT GAC ACG TAC CTT AT - #C CAC ATG GCA ATT GAG1260Leu Val Pro Glu Asn Ile Asp Thr Tyr Leu Il - #e His Met Ala Ile Glu# 13750- ATC CTT AAA CAT GGT CCT GAC AGC GGA CTT CA - #A CCT TCA TGT GAT GTC1308Ile Leu Lys His Gly Pro Asp Ser Gly Leu Gl - #n Pro Ser Cys Asp Val# 13905- AAC AAA AGG AGA TGT TTT CCC GGT TCT GAA GA - #G ATC TGT TCA AGT TCT1356Asn Lys Arg Arg Cys Phe Pro Gly Ser Glu Gl - #u Ile Cys Ser Ser Ser# 14101400 - # 1405- AAG AGA AGC AAG GAA GAA GTA GGC ATC AAT AC - #T GAG ACT TCA TCT GCA1404Lys Arg Ser Lys Glu Glu Val Gly Ile Asn Th - #r Glu Thr Ser Ser Ala# 14250- GAG AGA AAG AGA CGA TTA CCT GTG TGG TTT GC - #C AAA GGA AGT GAT ACC1452Glu Arg Lys Arg Arg Leu Pro Val Trp Phe Al - #a Lys Gly Ser Asp Thr# 14405- AGC AAG AAA TTA ATG GAC AAA ACG AAA AGG GG - #A GGT CTT TTT AGT1497Ser Lys Lys Leu Met Asp Lys Thr Lys Arg Gl - #y Gly Leu Phe Ser# 14550- TAAGCTGGCA ATTACCAGAA CAATTATGTT TCTTGCTGTA TTATAAGAGG AT - #AGCTATAT1557- TTTATTTCTG AAGAGTAAGG AGTAGTATTT TGGCTTAAAA ATCATTCTAA TT - #ACAAAGTT1617- CACTGTTTAT TGAAGAACTG GCATCTTAAA TCAGCCTTCC GCAATTCATG TA - #GTTTCTGG1677- GTCTTCTGGG AGCCTACGTG AGTACATCAC CTAACAGAAT ATTAAATTAG AC - #TTCCTGTA1737- AGATTGCTTT AAGAAACTGT TACTGTCCTG TTTTCTAATC TCTTTATTAA AA - #CAGTGTAT1797- TTGGAAAATG TTATGTGCTC TGATTTGATA TAGATAACAG ATTAGTAGTT AC - #ATGGTAAT1857- TATGTGATAT AAAATATTCA TATATTATCA AAATTCTGTT TTGTAAATGT AA - #GAAAGCAT1917- AGTTATTTTA CAAATTGTTT TTACTGTCTT TTGAAGAAGT TCTTAAATAC GT - #TGTTAAAT1977- GGTATTAGTT GACCAGGGCA GTGAAAATGA AACCGCATTT TGGGTGCCAT TA - #AATAGGGA2037- AAAAACATGT AAAAAATGTA AAATGGAGAC CAATTGCACT AGGCAAGTGT AT - #ATTTTGTA2097- TTTTATATAC AATTTCTATT ATTTTTCAAG TAATAAAACA ATGTTTTTCA TA - #CTGAATAT2157# 2178AA A- (2) INFORMATION FOR SEQ ID NO:73:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 395 amino (B) TYPE: amino acid (D) TOPOLOGY: linear- (ii) MOLECULE TYPE: protein- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73:- Met Lys Ile Cys Ala Leu Thr Lys Lys Gly Ar - #g Asn Trp Leu His Lys# 15- Ala Asn Thr Glu Ser Gln Ser Leu Ile Leu Gl - #n Ala Asn Glu Glu Leu# 30- Cys Pro Lys Lys Phe Leu Leu Pro Ser Ser Ly - #s Thr Val Ser Ser Gly# 45- Thr Lys Glu His Cys Tyr Asn Gln Val Pro Va - #l Glu Leu Ser Thr Glu# 60- Lys Lys Ser Asn Leu Glu Lys Leu Tyr Ser Ty - #r Lys Pro Cys Asp Lys# 80- Ile Ser Ser Gly Ser Asn Ile Ser Lys Lys Se - #r Ile Met Val Gln Ser# 95- Pro Glu Lys Ala Tyr Ser Ser Ser Gln Pro Va - #l Ile Ser Ala Gln Glu# 110- Gln Glu Thr Gln Ile Val Leu Tyr Gly Lys Le - #u Val Glu Ala Arg Gln# 125- Lys His Ala Asn Lys Met Asp Val Pro Pro Al - #a Ile Leu Ala Thr Asn# 140- Lys Ile Leu Val Asp Met Ala Lys Met Arg Pr - #o Thr Thr Val Glu Asn145 1 - #50 1 - #55 1 -#60- Val Lys Arg Ile Asp Gly Val Ser Glu Gly Ly - #s Ala Ala Met Leu Ala# 175- Pro Leu Leu Glu Val Ile Lys His Phe Cys Gl - #n Thr Asn Ser Val Gln# 190- Thr Asp Leu Phe Ser Ser Thr Lys Pro Gln Gl - #u Glu Gln Lys Thr Ser# 205- Leu Val Ala Lys Asn Lys Ile Cys Thr Leu Se - #r Gln Ser Met Ala Ile# 220- Thr Tyr Ser Leu Phe Gln Glu Lys Lys Met Pr - #o Leu Lys Ser Ile Ala225 2 - #30 2 - #35 2 -#40- Glu Ser Arg Ile Leu Pro Leu Met Thr Ile Gl - #y Met His Leu Ser Gln# 255- Ala Val Lys Ala Gly Cys Pro Leu Asp Leu Gl - #u Arg Ala Gly Leu Thr# 270- Pro Glu Val Gln Lys Ile Ile Ala Asp Val Il - #e Arg Asn Pro Pro Val# 285- Asn Ser Asp Met Ser Lys Ile Ser Leu Ile Ar - #g Met Leu Val Pro Glu# 300- Asn Ile Asp Thr Tyr Leu Ile His Met Ala Il - #e Glu Ile Leu Lys His305 3 - #10 3 - #15 3 -#20- Gly Pro Asp Ser Gly Leu Gln Pro Ser Cys As - #p Val Asn Lys Arg Arg# 335- Cys Phe Pro Gly Ser Glu Glu Ile Cys Ser Se - #r Ser Lys Arg Ser Lys# 350- Glu Glu Val Gly Ile Asn Thr Glu Thr Ser Se - #r Ala Glu Arg Lys Arg# 365- Arg Leu Pro Val Trp Phe Ala Lys Gly Ser As - #p Thr Ser Lys Lys Leu# 380- Met Asp Lys Thr Lys Arg Gly Gly Leu Phe Se - #r385 3 - #90 3 - #95- (2) INFORMATION FOR SEQ ID NO:74:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 1269 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74:- Glu Asp Gly Phe Glu Asp Gly Val Glu Asp As - #n Lys Leu Lys Glu Asn# 15- Met Glu Arg Ala Cys Leu Met Ser Leu Asp Il - #e Thr Glu His Glu Leu# 30- Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Ty - #r Leu Ser Asp Ile Ala# 45- Tyr Lys Ser Thr Glu His Leu Ser Pro Asn As - #p Asn Glu Asn Asp Thr# 60- Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Gl - #u Met Glu Met Leu Lys#80- His Leu Ser Pro Asn Asp Asn Glu Asn Asp Th - #r Ser Tyr Val Ile Glu# 95- Ser Asp Glu Asp Leu Glu Met Glu Met Leu Ly - #s Ser Leu Glu Asn Leu# 110- Asn Ser Gly Thr Val Glu Pro Thr His Ser Ly - #s Cys Leu Lys Met Glu# 125- Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Gl - #u Glu Asp Asp Glu Asn# 140- Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Ly - #s Asp Phe Leu Trp Pro145 1 - #50 1 - #55 1 -#60- Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Ly - #s Met Tyr Phe Gly His# 175- Ser Ser Phe Lys Pro Val Gln Trp Lys Val Il - #e His Ser Val Leu Glu# 190- Glu Arg Arg Asp Asn Val Ala Val Met Ala Th - #r Gly Tyr Gly Lys Ser# 205- Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gl - #y Lys Ile Gly Leu Val# 220- Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gl - #n Val Leu Gln Leu Lys225 2 - #30 2 - #35 2 -#40- Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Se - #r Ala Gln Ser Glu Asn# 255- Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Ar - #g Ile Val Tyr Val Thr# 270- Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Le - #u Gln Gln Leu Glu Ala# 285- Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Gl - #u Ala His Cys Ile Ser# 300- Glu Trp Gly His Asp Phe Arg Asp Ser Phe Ar - #g Lys Leu Gly Ser Leu305 3 - #10 3 - #15 3 -#20- Lys Thr Ala Leu Pro Met Val Pro Ile Val Al - #a Leu Thr Ala Thr Ala# 335- Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cy - #s Leu Asn Leu Arg Asn# 350- Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pr - #o Asn Leu Tyr Leu Glu# 365- Val Arg Arg Lys Thr Gly Asn Ile Leu Gln As - #p Leu Gln Pro Phe Leu# 380- Val Lys Thr Ser Ser His Trp Glu Phe Glu Gl - #y Pro Thr Ile Ile Tyr385 3 - #90 3 - #95 4 -#00- Cys Pro Ser Arg Lys Met Thr Gln Gln Val Th - #r Gly Glu Leu Arg Lys# 415- Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gl - #y Met Ser Phe Ser Thr# 430- Arg Lys Asp Ile His His Arg Phe Val Arg As - #p Glu Ile Gln Cys Val# 445- Ile Ala Thr Ile Ala Phe Gly Met Gly Ile As - #n Lys Ala Asp Ile Arg# 460- Gln Val Ile His Tyr Gly Ala Pro Lys Asp Me - #t Glu Ser Tyr Tyr Gln465 4 - #70 4 - #75 4 -#80- Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gl - #n Ser Ser Cys His Val# 495- Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Ar - #g His Leu Leu Thr Glu# 510- Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Le - #u Lys Met Met Ala Lys# 525- Met Glu Lys Tyr Leu His Ser Ser Arg Cys Ar - #g Arg Gln Ile Ile Leu# 540- Ser His Phe Glu Asp Lys Gln Val Gln Lys Al - #a Ser Leu Gly Ile Met545 5 - #50 5 - #55 5 -#60- Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Se - #r Arg Leu Asp His Cys# 575- Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Tr - #p Asp Phe Gly Pro Gln# 590- Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Le - #u Gly Glu Lys Phe Gly# 605- Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Se - #r Asn Ser Gln Arg Leu# 620- Ala Asp Gln Tyr Arg Arg His Ser Leu Phe Gl - #y Thr Gly Lys Asp Gln625 6 - #30 6 - #35 6 -#40- Thr Glu Ser Trp Trp Lys Ala Phe Ser Arg Gl - #n Leu Ile Thr Glu Gly# 655- Phe Leu Val Glu Val Ser Arg Tyr Asn Lys Ph - #e Met Lys Ile Cys Ala# 670- Leu Thr Lys Lys Gly Arg Asn Trp Leu His Ly - #s Ala Asn Thr Glu Ser# 685- Gln Ser Leu Ile Leu Gln Ala Asn Glu Glu Le - #u Cys Pro Lys Lys Phe# 700- Leu Leu Pro Ser Ser Lys Thr Val Ser Ser Gl - #y Thr Lys Glu His Cys705 7 - #10 7 - #15 7 -#20- Tyr Asn Gln Val Pro Val Glu Leu Ser Thr Gl - #u Lys Lys Ser Asn Leu# 735- Glu Lys Leu Tyr Ser Tyr Lys Pro Cys Asp Ly - #s Ile Ser Ser Gly Ser# 750- Asn Ile Ser Lys Lys Ser Ile Met Val Gln Se - #r Pro Glu Lys Ala Tyr# 765- Ser Ser Ser Gln Pro Val Ile Ser Ala Gln Gl - #u Gln Glu Thr Gln Ile# 780- Val Leu Tyr Gly Lys Leu Val Glu Ala Arg Gl - #n Lys His Ala Asn Lys785 7 - #90 7 - #95 8 -#00- Met Asp Val Pro Pro Ala Ile Leu Ala Thr As - #n Lys Ile Leu Val Asp# 815- Met Ala Lys Met Arg Pro Thr Thr Val Glu As - #n Val Lys Arg Ile Asp# 830- Gly Val Ser Glu Gly Lys Ala Ala Met Leu Al - #a Pro Leu Leu Glu Val# 845- Ile Lys His Phe Cys Gln Thr Asn Ser Val Gl - #n Thr Asp Leu Phe Ser# 860- Ser Thr Lys Pro Gln Glu Glu Gln Lys Thr Se - #r Leu Val Ala Lys Asn865 8 - #70 8 - #75 8 -#80- Lys Ile Cys Thr Leu Ser Gln Ser Met Ala Il - #e Thr Tyr Ser Leu Phe# 895- Gln Glu Lys Lys Met Pro Leu Lys Ser Ile Al - #a Glu Ser Arg Ile Leu# 910- Pro Leu Met Thr Ile Gly Met His Leu Ser Gl - #n Ala Val Lys Ala Gly# 925- Cys Pro Leu Asp Leu Glu Arg Ala Gly Leu Th - #r Pro Glu Val Gln Lys# 940- Ile Ile Ala Asp Val Ile Arg Asn Pro Pro Va - #l Asn Ser Asp Met Ser945 9 - #50 9 - #55 9 -#60- Lys Ile Ser Leu Ile Arg Met Leu Val Pro Gl - #u Asn Ile Asp Thr Tyr# 975- Leu Ile His Met Ala Ile Glu Ile Leu Lys Hi - #s Gly Pro Asp Ser Gly# 990- Leu Gln Pro Ser Cys Asp Val Asn Lys Arg Ar - #g Cys Phe Pro Gly Ser# 10050- Glu Glu Ile Cys Ser Ser Ser Lys Arg Ser Ly - #s Glu Glu Val Gly Ile# 10205- Asn Thr Glu Thr Ser Ser Ala Glu Arg Lys Ar - #g Arg Leu Pro Val Trp# 10401030 - # 1035- Phe Ala Lys Gly Ser Asp Thr Ser Lys Lys Le - #u Met Asp Lys Thr Lys# 10550- Arg Gly Gly Leu Phe Ser Ala Gly Asn Tyr Gl - #n Asn Asn Tyr Val Ser# 10705- Cys Cys Ile Ile Arg Gly Leu Tyr Phe Ile Se - #r Glu Glu Gly Val Val# 10850- Phe Trp Leu Lys Asn His Ser Asn Tyr Lys Va - #l His Cys Leu Leu Lys# 11005- Asn Trp His Leu Lys Ser Ala Phe Arg Asn Se - #r Cys Ser Phe Trp Val# 11201110 - # 1115- Phe Trp Glu Pro Thr Val His His Leu Thr Gl - #u Tyr Ile Arg Leu Pro# 11350- Val Arg Leu Leu Glu Thr Val Thr Val Leu Ph - #e Ser Asn Leu Phe Ile# 11505- Lys Thr Val Tyr Leu Glu Asn Val Met Cys Se - #r Asp Leu Ile Ile Thr# 11650- Asp Leu His Gly Asn Tyr Val Ile Asn Ile Hi - #s Ile Leu Ser Lys Phe# 11805- Cys Phe Val Asn Val Arg Lys His Ser Tyr Ph - #e Thr Asn Cys Phe Tyr# 12001190 - # 1195- Cys Leu Leu Lys Lys Phe Leu Asn Thr Leu Le - #u Asn Gly Ile Ser Pro# 12150- Gly Gln Lys Asn Arg Ile Leu Gly Ala Ile Ly - #s Gly Lys Asn Met Lys# 12305- Met Asn Gly Asp Gln Leu His Ala Ser Val Ty - #r Phe Val Phe Tyr Ile# 12450- Gln Phe Leu Leu Phe Phe Lys Asn Asn Val Ph - #e His Thr Glu Tyr Lys# 12605- Lys Lys Lys Lys Lys1265- (2) INFORMATION FOR SEQ ID NO:75:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 607 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75:- Ala Gln Ala Glu Val Leu Asn Leu Glu Ser Gl - #y Ala Lys Gln Val Leu# 15- Gln Glu Thr Phe Gly Tyr Gln Gln Phe Arg Pr - #o Gly Gln Glu Glu Ile# 30- Ile Asp Thr Val Leu Ser Gly Arg Asp Cys Le - #u Val Val Met Pro Thr# 45- Gly Gly Gly Lys Ser Leu Cys Tyr Gln Ile Pr - #o Ala Leu Leu Leu Asn# 60- Gly Leu Thr Val Val Val Ser Pro Leu Ile Se - #r Leu Met Lys Asp Gln#80- Val Asp Gln Leu Gln Ala Asn Gly Val Ala Al - #a Ala Cys Leu Asn Ser# 95- Thr Gln Thr Arg Glu Gln Gln Leu Glu Val Me - #t Thr Gly Cys Arg Thr# 110- Gly Gln Ile Arg Leu Leu Tyr Ile Ala Pro Gl - #u Arg Leu Met Leu Asp# 125- Asn Phe Leu Glu His Leu Ala His Trp Asn Pr - #o Val Leu Leu Ala Val# 140- Asp Glu Ala His Cys Ile Ser Gln Trp Gly Hi - #s Asp Phe Arg Pro Glu145 1 - #50 1 - #55 1 -#60- Tyr Ala Ala Leu Gly Gln Leu Arg Gln Arg Ph - #e Pro Thr Leu Pro Phe# 175- Met Ala Leu Thr Ala Thr Ala Asp Asp Thr Th - #r Arg Gln Asp Ile Val# 190- Arg Leu Leu Gly Leu Asn Asp Pro Leu Ile Gl - #n Ile Ser Ser Phe Asp# 205- Arg Pro Asn Ile Arg Tyr Met Leu Met Glu Ly - #s Phe Lys Pro Leu Asp# 220- Gln Leu Met Arg Tyr Val Gln Glu Gln Arg Gl - #y Lys Ser Gly Ile Ile225 2 - #30 2 - #35 2 -#40- Tyr Cys Asn Ser Arg Ala Lys Val Glu Asp Th - #r Ala Ala Ala Leu Gln# 255- Ser Lys Gly Ile Ser Ala Ala Ala Tyr His Al - #a Gly Leu Glu Asn Asn# 270- Val Arg Ala Asp Val Gln Glu Lys Phe Gln Ar - #g Asp Asp Leu Gln Ile# 285- Val Val Ala Thr Val Ala Phe Gly Met Gly Il - #e Asn Lys Pro Asn Val# 300- Arg Phe Val Val His Phe Asp Ile Pro Arg As - #n Ile Glu Ser Tyr Tyr305 3 - #10 3 - #15 3 -#20- Gln Glu Thr Gly Arg Ala Gly Arg Asp Gly Le - #u Pro Ala Glu Ala Met# 335- Leu Phe Tyr Asp Pro Ala Asp Met Ala Trp Le - #u Arg Arg Cys Leu Glu# 350- Glu Lys Pro Gln Gly Gln Leu Gln Asp Ile Gl - #u Arg His Lys Leu Asn# 365- Ala Met Gly Ala Phe Ala Glu Ala Gln Thr Cy - #s Arg Arg Leu Val Leu# 380- Leu Asn Tyr Phe Gly Glu Gly Arg Gln Glu Pr - #o Cys Gly Asn Cys Asp385 3 - #90 3 - #95 4 -#00- Ile Cys Leu Asp Pro Pro Lys Gln Tyr Asp Gl - #y Ser Thr Asp Ala Gln# 415- Ile Ala Leu Ser Thr Ile Gly Arg Val Asn Gl - #n Arg Phe Gly Met Gly# 430- Tyr Val Val Glu Val Ile Arg Gly Ala Asn As - #n Gln Arg Ile Arg Asp# 445- Tyr Gly His Asp Lys Leu Lys Val Tyr Gly Me - #t Gly Arg Asp Lys Ser# 460- His Glu His Trp Val Ser Val Ile Arg Gln Le - #u Ile His Leu Gly Leu465 4 - #70 4 - #75 4 -#80- Val Thr Gln Asn Ile Ala Gln His Ser Ala Le - #u Gln Leu Thr Glu Ala# 495- Ala Arg Pro Val Leu Ala Glu Ser Ser Leu Gl - #n Leu Ala Val Pro Arg# 510- Ile Val Ala Leu Lys Pro Lys Ala Met Gln Ly - #s Ser Phe Gly Gly Asn# 525- Tyr Asp Arg Lys Leu Phe Ala Lys Leu Arg Ly - #s Leu Arg Lys Ser Ile# 540- Ala Asp Glu Ser Asn Val Pro Pro Tyr Val Va - #l Phe Asn Asp Ala Thr545 5 - #50 5 - #55 5 -#60- Leu Ile Glu Met Ala Glu Gln Met Pro Ile Th - #r Ala Ser Glu Met Leu# 575- Ser Val Asn Gly Val Gly Met Arg Lys Leu Gl - #u Arg Phe Gly Lys Pro# 590- Phe Met Ala Leu Ile Arg Ala His Val Asp Gl - #y Asp Asp Glu Glu# 605- (2) INFORMATION FOR SEQ ID NO:76:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 1328 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:76:- Met Thr Val Thr Lys Thr Asn Leu Asn Arg Hi - #s Leu Asp Trp Phe Phe# 15- Arg Glu Ser Pro Gln Lys Ile Glu Asn Val Th - #r Ser Pro Ile Lys Thr# 30- Leu Asp Phe Val Lys Val Lys Val Ser Ser Se - #r Asp Ile Val Val Lys# 45- Asp Ser Ile Pro His Lys Ser Lys Asn Val Ph - #e Asp Asp Phe Asp Asp# 60- Gly Tyr Ala Ile Asp Leu Thr Glu Glu His Gl - #n Ser Ser Ser Leu Asn#80- Asn Leu Lys Trp Lys Asp Val Glu Gly Pro As - #n Ile Leu Lys Pro Ile# 95- Lys Lys Ile Ala Val Pro Ala Ser Glu Ser Gl - #u Glu Asp Phe Asp Asp# 110- Val Asp Glu Glu Met Leu Arg Ala Ala Glu Me - #t Glu Val Phe Gln Ser# 125- Cys Gln Pro Leu Ala Val Asn Thr Ala Asp Th - #r Thr Val Ser His Ser# 140- Thr Ser Ser Ser Asn Val Pro Arg Ser Leu As - #n Lys Ile His Asp Pro145 1 - #50 1 - #55 1 -#60- Ser Arg Phe Ile Lys Asp Asn Asp Val Glu As - #n Arg Ile His Val Ser# 175- Ser Ala Ser Lys Val Ala Ser Ile Ser Asn Th - #r Ser Lys Pro Asn Pro# 190- Ile Val Ser Glu Asn Pro Ile Ser Ala Thr Se - #r Val Ser Ile Glu Ile# 205- Pro Ile Lys Pro Lys Glu Leu Ser Asn Asn Le - #u Pro Phe Pro Arg Leu# 220- Asn Asn Asn Asn Thr Asn Asn Asn Asn Asp As - #n Asn Ala Ile Glu Lys225 2 - #30 2 - #35 2 -#40- Arg Asp Ser Ala Ser Pro Thr Pro Ser Ser Va - #l Ser Ser Gln Ile Ser# 255- Ile Asp Phe Ser Thr Trp Pro His Gln Asn Le - #u Leu Gln Tyr Leu Asp# 270- Ile Leu Arg Asp Glu Lys Ser Glu Ile Ser As - #p Arg Ile Ile Glu Val# 285- Met Glu Arg Tyr Pro Phe Ser Ser Arg Phe Ly - #s Glu Trp Ile Pro Lys# 300- Arg Asp Ile Leu Ser Gln Lys Ile Ser Ser Va - #l Leu Glu Val Leu Ser305 3 - #10 3 - #15 3 -#20- Asn Asn Asn Asn Ser Asn Asn Asn Asn Gly As - #n Asn Gly Thr Val Pro# 335- Asn Ala Lys Thr Phe Phe Thr Pro Pro Ser Se - #r Ile Thr Gln Gln Val# 350- Pro Phe Pro Ser Thr Ile Ile Pro Glu Ser Th - #r Val Lys Glu Asn Ser# 365- Thr Arg Pro Tyr Val Asn Ser His Leu Val Al - #a Asn Asp Lys Ile Thr# 380- Ala Thr Pro Phe His Ser Glu Ala Val Val Se - #r Pro Leu Gln Ser Asn385 3 - #90 3 - #95 4 -#00- Ile Arg Asn Ser Asp Ile Ala Glu Phe Asp Gl - #u Phe Asp Ile Asp Asp# 415- Ala Asp Phe Thr Phe Asn Thr Thr Asp Pro Il - #e Asn Asp Glu Ser Gly# 430- Ala Ser Ser Asp Val Val Val Ile Asp Asp Gl - #u Glu Asp Asp Ile Glu# 445- Asn Arg Pro Leu Asn Gln Ala Leu Lys Ala Se - #r Lys Ala Ala Val Ser# 460- Asn Ala Ser Leu Leu Gln Ser Ser Ser Leu As - #p Arg Pro Leu Leu Gly465 4 - #70 4 - #75 4 -#80- Glu Met Lys Asp Lys Asn His Lys Val Leu Me - #t Pro Ser Leu Asp Asp# 495- Pro Met Leu Ser Tyr Pro Trp Ser Lys Glu Va - #l Leu Gly Cys Leu Lys# 510- His Lys Phe His Leu Lys Gly Phe Arg Lys As - #n Gln Leu Glu Ala Ile# 525- Asn Gly Thr Leu Ser Gly Lys Asp Val Phe Il - #e Leu Met Pro Thr Gly# 540- Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Al - #a Val Ile Glu Gly Gly545 5 - #50 5 - #55 5 -#60- Ala Ser Arg Gly Val Thr Leu Val Ile Ser Pr - #o Leu Leu Ser Leu Met# 575- Gln Asp Gln Leu Asp His Leu Arg Lys Leu As - #n Ile Pro Ser Leu Pro# 590- Leu Ser Gly Glu Gln Pro Ala Asp Glu Arg Ar - #g Gln Val Ile Ser Phe# 605- Leu Met Ala Lys Asn Val Leu Val Lys Leu Le - #u Tyr Val Thr Pro Glu# 620- Gly Leu Ala Ser Asn Gly Ala Ile Thr Arg Va - #l Leu Lys Ser Leu Tyr625 6 - #30 6 - #35 6 -#40- Glu Arg Lys Leu Leu Ala Arg Ile Val Ile As - #p Glu Ala His Cys Val# 655- Ser His Trp Gly His Asp Phe Arg Pro Asp Ty - #r Lys Gln Leu Gly Leu# 670- Leu Arg Asp Arg Tyr Gln Gly Ile Pro Phe Me - #t Ala Leu Thr Ala Thr# 685- Ala Asn Glu Ile Val Lys Lys Asp Ile Ile As - #n Thr Leu Arg Met Glu# 700- Asn Cys Leu Glu Leu Lys Ser Ser Phe Asn Ar - #g Pro Asn Leu Phe Tyr705 7 - #10 7 - #15 7 -#20- Glu Ile Lys Pro Lys Lys Asp Leu Tyr Thr Gl - #u Leu Tyr Arg Phe Ile# 735- Ser Asn Gly His Leu His Glu Ser Gly Ile Il - #e Tyr Cys Leu Ser Arg# 750- Thr Ser Cys Glu Gln Val Ala Ala Lys Leu Ar - #g Asn Asp Tyr Gly Leu# 765- Lys Ala Trp His Tyr His Ala Gly Leu Glu Ly - #s Val Glu Arg Gln Arg# 780- Ile Gln Asn Glu Trp Gln Ser Gly Ser Tyr Ly - #s Ile Ile Val Ala Thr785 7 - #90 7 - #95 8 -#00- Ile Ala Phe Gly Met Gly Val Asp Lys Gly As - #p Val Arg Phe Val Ile# 815- His His Ser Phe Pro Lys Ser Leu Glu Gly Ty - #r Tyr Gln Glu Thr Gly# 830- Arg Ala Gly Arg Asp Gly Lys Pro Ala His Cy - #s Ile Met Phe Tyr Ser# 845- Tyr Lys Asp His Val Thr Phe Gln Lys Leu Il - #e Met Ser Gly Asp Gly# 860- Asp Ala Glu Thr Lys Glu Arg Gln Arg Gln Me - #t Leu Arg Gln Val Ile865 8 - #70 8 - #75 8 -#80- Gln Phe Cys Glu Asn Lys Thr Asp Cys Arg Ar - #g Lys Gln Val Leu Ala# 895- Tyr Phe Gly Glu Asn Phe Asp Lys Val His Cy - #s Arg Lys Gly Cys Asp# 910- Ile Cys Cys Glu Glu Ala Thr Tyr Ile Lys Gl - #n Asp Met Thr Glu Phe# 925- Ser Leu Gln Ala Ile Lys Leu Leu Lys Ser Il - #e Ser Gly Lys Ala Thr# 940- Leu Leu Gln Leu Met Asp Ile Phe Arg Gly Se - #r Lys Ser Ala Lys Ile945 9 - #50 9 - #55 9 -#60- Val Glu Asn Gly Trp Asp Arg Leu Glu Gly Al - #a Gly Val Gly Lys Leu# 975- Leu Asn Arg Gly Asp Ser Glu Arg Leu Phe Hi - #s His Leu Val Ser Glu# 990- Gly Val Phe Val Glu Lys Val Glu Ala Asn Ar - #g Arg Gly Phe Val Ser# 10050- Ala Tyr Val Val Pro Gly Arg Gln Thr Ile Il - #e Asn Ser Val Leu Ala# 10205- Gly Lys Arg Arg Ile Ile Leu Asp Val Lys Gl - #u Ser Ser Ser Lys Pro# 10401030 - # 1035- Asp Thr Ser Ser Arg Ser Leu Ser Arg Ser Ly - #s Thr Leu Pro Ala Leu# 10550- Arg Glu Tyr Gln Leu Lys Ser Thr Thr Ala Se - #r Val Asp Cys Ser Ile# 10705- Gly Thr Arg Glu Val Asp Glu Ile Tyr Asp Se - #r Gln Met Pro Pro Val# 10850- Lys Pro Ser Leu Ile His Ser Arg Asn Lys Il - #e Asp Leu Glu Glu Leu# 11005- Ser Gly Gln Lys Phe Met Ser Glu Tyr Glu Il - #e Asp Val Met Thr Arg# 11201110 - # 1115- Cys Leu Lys Asp Leu Lys Leu Leu Arg Ser As - #n Leu Met Ala Ile Asp# 11350- Asp Ser Arg Val Ser Ser Tyr Phe Thr Asp Se - #r Val Leu Leu Ser Met# 11505- Ala Lys Lys Leu Pro Arg Asn Val Lys Glu Le - #u Lys Glu Ile His Gly# 11650- Val Ser Asn Glu Lys Ala Val Asn Leu Gly Pr - #o Lys Phe Leu Gln Val# 11805- Ile Gln Lys Phe Ile Asp Glu Lys Glu Gln As - #n Leu Glu Gly Thr Glu# 12001190 - # 1195- Leu Asp Pro Ser Leu Gln Ser Leu Asp Thr As - #p Tyr Pro Ile Asp Thr# 12150- Asn Ala Leu Ser Leu Asp His Glu Gln Gly Ph - #e Ser Asp Asp Ser Asp# 12305- Ser Val Tyr Glu Pro Ser Ser Pro Ile Glu Gl - #u Gly Asp Glu Glu Val# 12450- Asp Gly Gln Arg Lys Asp Ile Leu Asn Phe Me - #t Asn Ser Gln Ser Leu# 12605- Thr Gln Thr Gly Ser Val Pro Lys Arg Lys Se - #r Thr Ser Tyr Thr Arg# 12801270 - # 1275- Pro Ser Lys Ser Tyr Arg His Lys Arg Gly Se - #r Thr Ser Tyr Ser Arg# 12950- Lys Arg Lys Tyr Ser Thr Ser Gln Lys Asp Se - #r Arg Lys Thr Ser Lys# 13105- Ser Ala Asn Thr Ser Phe Ile His Pro Met Va - #l Lys Gln Asn Tyr Arg# 13250- (2) INFORMATION FOR SEQ ID NO:77:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 659 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77:- Met Ala Ser Val Ser Ala Leu Thr Glu Glu Le - #u Asp Ser Ile Thr Ser# 15- Glu Leu His Ala Val Glu Ile Gln Ile Gln Gl - #u Leu Thr Glu Arg Gln# 30- Gln Glu Leu Ile Gln Lys Lys Lys Val Leu Th - #r Lys Lys Ile Lys Gln# 45- Cys Leu Glu Asp Ser Asp Ala Gly Ala Ser As - #n Glu Tyr Asp Ser Ser# 60- Pro Ala Ala Trp Asn Lys Glu Asp Phe Pro Tr - #p Ser Gly Lys Val Lys#80- Asp Ile Leu Gln Asn Val Phe Lys Leu Glu Ly - #s Phe Arg Pro Leu Gln# 95- Leu Glu Thr Ile Asn Val Thr Met Ala Gly Ly - #s Glu Val Phe Leu Val# 110- Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Ty - #r Gln Leu Pro Ala Leu# 125- Cys Ser Asp Gly Phe Thr Leu Val Ile Cys Pr - #o Leu Ile Ser Leu Met# 140- Glu Asp Gln Leu Met Val Leu Lys Gln Leu Gl - #y Ile Ser Ala Thr Met145 1 - #50 1 - #55 1 -#60- Leu Asn Ala Ser Ser Ser Lys Glu His Val Ly - #s Trp Val His Asp Glu# 175- Met Val Asn Lys Asn Ser Glu Leu Lys Leu Il - #e Tyr Val Thr Pro Glu# 190- Lys Ile Ala Lys Ser Lys Met Phe Met Ser Ar - #g Leu Glu Lys Ala Tyr# 205- Glu Ala Arg Arg Phe Thr Arg Ile Ala Val As - #p Glu Val His Cys Cys# 220- Ser Gln Trp Gly His Asp Phe Arg Pro Asp Ty - #r Lys Ala Leu Gly Ile225 2 - #30 2 - #35 2 -#40- Leu Lys Arg Gln Phe Pro Asn Ala Ser Leu Il - #e Gly Leu Thr Ala Thr# 255- Ala Thr Asn His Val Leu Thr Asp Ala Gln Ly - #s Ile Leu Cys Ile Glu# 270- Lys Cys Phe Thr Phe Thr Ala Ser Phe Asn Ar - #g Pro Asn Leu Tyr Tyr# 285- Glu Val Arg Gln Lys Pro Ser Asn Thr Glu As - #p Phe Ile Glu Asp Ile# 300- Val Lys Leu Ile Asn Gly Arg Tyr Lys Gly Gl - #n Ser Gly Ile Ile Tyr305 3 - #10 3 - #15 3 -#20- Cys Phe Ser Gln Lys Asp Ser Glu Gln Val Th - #r Val Ser Leu Gln Asn# 335- Leu Gly Ile His Ala Gly Ala Tyr His Ala As - #n Leu Glu Pro Glu Asp# 350- Lys Thr Thr Val His Arg Lys Trp Ser Ala As - #n Glu Ile Gln Val Val# 365- Val Ala Thr Val Ala Phe Gly Met Gly Ile As - #p Lys Pro Asp Val Arg# 380- Phe Val Ile His His Ser Met Ser Lys Ser Me - #t Glu Asn Tyr Tyr Gln385 3 - #90 3 - #95 4 -#00- Glu Ser Gly Arg Ala Gly Arg Asp Asp Met Ly - #s Ala Asp Cys Ile Leu# 415- Tyr Tyr Gly Phe Gly Asp Ile Phe Arg Ile Se - #r Ser Met Val Val Met# 430- Glu Asn Val Gly Gln Gln Lys Leu Tyr Glu Me - #t Val Ser Tyr Cys Gln# 445- Asn Ile Ser Lys Ser Arg Arg Val Leu Met Al - #a Gln His Phe Asp Glu# 460- Val Trp Asn Ser Glu Ala Cys Asn Lys Met Cy - #s Asp Asn Cys Cys Lys465 4 - #70 4 - #75 4 -#80- Asp Ser Ala Phe Glu Arg Thr Asn Ile Thr Gl - #u Tyr Cys Arg Asp Leu# 495- Ile Lys Ile Leu Lys Gln Ala Glu Glu Leu As - #n Glu Lys Leu Thr Pro# 510- Leu Lys Leu Ile Asp Ser Trp Met Gly Lys Gl - #y Ala Ala Lys Leu Arg# 525- Val Ala Gly Val Val Ala Pro Thr Leu Pro Ar - #g Glu Asp Leu Glu Lys# 540- Ile Ile Ala His Phe Leu Ile Gln Gln Tyr Le - #u Lys Glu Asp Tyr Ser545 5 - #50 5 - #55 5 -#60- Phe Thr Ala Tyr Ala Ala Ile Ser Tyr Leu Ly - #s Ile Gly Pro Lys Ala# 575- Asn Leu Leu Asn Asn Glu Ala His Ala Ile Th - #r Met Gln Val Thr Lys# 590- Ser Thr Gln Asn Ser Phe Arg Ala Glu Ser Se - #r Gln Thr Cys His Ser# 605- Glu Gln Gly Asp Lys Lys Asn Gly Gly Lys Ly - #s Ile Gln Ala Thr Ser# 620- Arg Arg Arg Leu Gln Thr Cys Phe Ser Asn Le - #u Val Leu Arg Ile Gln625 6 - #30 6 - #35 6 -#40- Glu Leu Arg Lys Glu Lys Ser Met Met Pro As - #p Met Asn Val Thr Lys# 655- Phe Ser Asn- (2) INFORMATION FOR SEQ ID NO:78:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 1417 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78:- Met Ala Ala Val Pro Gln Asn Asn Leu Gln Gl - #u Gln Leu Glu Arg His# 15- Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Le - #u Ser Lys Pro Lys Phe# 30- Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Se - #r Asp Asn Asn Val Ser# 45- Val Thr Asn Val Ser Val Ala Lys Thr Pro Va - #l Leu Arg Asn Lys Asp# 60- Val Asn Val Thr Glu Asp Phe Ser Phe Ser Gl - #u Pro Leu Pro Asn Thr#80- Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Ly - #s Asn Ala Pro Ala Gly# 95- Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Le - #u Leu Pro Asp Phe Leu# 110- Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gl - #n Asn Thr Pro Thr Val# 125- Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Le - #u Glu Phe Ser Ser Ser# 140- Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp As - #p Asp Met Asp Asp Phe145 1 - #50 1 - #55 1 -#60- Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Th - #r Pro Pro Gln Ser His# 175- Phe Val Arg Val Ser Thr Ala Gln Lys Ser Ly - #s Lys Gly Lys Arg Asn# 190- Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Th - #r Val Lys Thr Asp Leu# 205- Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile As - #p Leu Thr Glu Glu Gln# 220- Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Va - #l Ile Cys Ile Asp Asp225 2 - #30 2 - #35 2 -#40- Gly Pro Ile Ala Glu Val His Ile Asn Glu As - #p Ala Gln Glu Ser Asp# 255- Ser Leu Lys Thr His Leu Glu Asp Glu Arg As - #p Asn Ser Glu Lys Lys# 270- Lys Asn Leu Glu Glu Ala Glu Leu His Ser Th - #r Glu Lys Val Pro Cys# 285- Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr As - #p Phe Val Pro Pro Ser# 300- Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Se - #r Ser Lys Cys Leu Ser305 3 - #10 3 - #15 3 -#20- Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Ly - #s Glu Asp Val Leu Ser# 335- Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Ly - #s Met Ser Met Gln Glu# 350- Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Al - #a Arg Gln Ile Ser Leu# 365- Gln Gln Gln Leu Ile His Val Met Glu His Il - #e Cys Lys Leu Ile Asp# 380- Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu As - #p Cys Gly Asn Glu Leu385 3 - #90 3 - #95 4 -#00- Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Le - #u Thr Glu Val Asp Phe# 415- Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Le - #u Trp Arg Tyr Arg Pro# 430- Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Se - #r Cys Pro Thr Gly Asn# 445- Ser Met Lys Glu Leu Asn Phe Ser His Leu Pr - #o Ser Asn Ser Val Ser# 460- Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gl - #y Lys Thr Gly Phe Ser465 4 - #70 4 - #75 4 -#80- Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Le - #u Phe Asn Thr His Leu# 495- Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Gl - #u Thr Pro Arg Leu Gly# 510- Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly As - #n Val Leu Thr Ser Thr# 525- Ala Val Lys Asp Gln Asn Lys His Thr Ala Se - #r Ile Asn Asp Leu Glu# 540- Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp As - #n Phe Asp Ile Asp Asp545 5 - #50 5 - #55 5 -#60- Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Me - #t His Asn Leu Ala Ala# 575- Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Il - #e Lys Glu Gly Arg Pro# 590- Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Al - #a Lys Thr Asp Cys Leu# 605- Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Ph - #e Ser Glu Ser Ile Gln# 620- Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Al - #a Ser Arg Asn Leu Lys625 6 - #30 6 - #35 6 -#40- His Glu Arg Phe Gln Ser Leu Ser Phe Pro Hi - #s Thr Lys Glu Met Met# 655- Lys Ile Phe His Lys Lys Phe Gly Leu His As - #n Phe Arg Thr Asn Gln# 670- Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Gl - #u Asp Cys Phe Ile Leu# 685- Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Ty - #r Gln Leu Pro Ala Cys# 700- Val Ser Pro Gly Val Thr Val Val Ile Ser Pr - #o Leu Arg Ser Leu Ile705 7 - #10 7 - #15 7 -#20- Val Asp Gln Val Gln Lys Leu Thr Ser Leu As - #p Ile Pro Ala Thr Tyr# 735- Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Th - #r Asn Ile Tyr Leu Gln# 750- Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Le - #u Tyr Val Thr Pro Glu# 765- Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Th - #r Leu Glu Asn Leu Tyr# 780- Glu Arg Lys Leu Leu Ala Arg Phe Val Ile As - #p Glu Ala His Cys Val785 7 - #90 7 - #95 8 -#00- Ser Gln Trp Gly His Asp Phe Arg Gln Asp Ty - #r Lys Arg Met Asn Met# 815- Leu Arg Gln Lys Phe Pro Ser Val Pro Val Me - #t Ala Leu Thr Ala Thr# 830- Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Th - #r Gln Leu Lys Ile Leu# 845- Arg Pro Gln Val Phe Ser Met Ser Phe Asn Ar - #g His Asn Leu Lys Tyr# 860- Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Al - #a Phe Asp Cys Leu Glu865 8 - #70 8 - #75 8 -#80- Trp Ile Arg Lys His His Pro Tyr Asp Ser Gl - #y Ile Ile Tyr Cys Leu# 895- Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Th - #r Leu Gln Arg Asp Gly# 910- Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Se - #r Asp Ser Ala Arg Asp# 925- Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gl - #y Cys Gln Val Ile Cys# 940- Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Ly - #s Pro Asp Val Arg Phe945 9 - #50 9 - #55 9 -#60- Val Ile His Ala Ser Leu Pro Lys Ser Val Gl - #u Gly Tyr Tyr Gln Glu# 975- Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Se - #r His Cys Leu Leu Phe# 990- Tyr Thr Tyr His Asp Val Thr Arg Leu Lys Ar - #g Leu Ile Met Met Glu# 10050- Lys Asp Gly Asn His His Thr Arg Glu Thr Hi - #s Phe Asn Asn Leu Tyr# 10205- Ser Met Val His Tyr Cys Glu Asn Ile Thr Gl - #u Cys Arg Arg Ile Gln# 10401030 - # 1035- Leu Leu Ala Tyr Phe Gly Glu Asn Gly Phe As - #n Pro Asp Phe Cys Lys# 10550- Lys His Pro Asp Val Ser Cys Asp Asn Cys Cy - #s Lys Thr Lys Asp Tyr# 10705- Lys Thr Arg Asp Val Thr Asp Asp Val Lys Se - #r Ile Val Arg Phe Val# 10850- Gln Glu His Ser Ser Ser Gln Gly Met Arg As - #n Ile Lys His Val Gly# 11005- Pro Ser Gly Arg Phe Thr Met Asn Met Leu Va - #l Asp Ile Phe Leu Gly# 11201110 - # 1115- Ser Lys Ser Ala Lys Ile Gln Ser Gly Ile Ph - #e Gly Lys Gly Ser Ala# 11350- Tyr Ser Arg His Asn Ala Glu Arg Leu Phe Ly - #s Lys Leu Ile Leu Asp# 11505- Lys Ile Leu Asp Glu Asp Leu Tyr Ile Asn Al - #a Asn Asp Gln Ala Ile# 11650- Ala Tyr Val Met Leu Gly Asn Lys Ala Gln Th - #r Val Leu Asn Gly Asn# 11805- Leu Lys Val Asp Phe Met Glu Thr Glu Asn Se - #r Ser Ser Val Lys Lys# 12001190 - # 1195- Gln Lys Ala Leu Val Ala Lys Val Ser Gln Ar - #g Glu Glu Met Val Lys# 12150- Lys Cys Leu Gly Glu Leu Thr Glu Val Cys Ly - #s Ser Leu Gly Lys Val# 12305- Phe Gly Val His Tyr Phe Asn Ile Phe Asn Th - #r Val Thr Leu Lys Lys# 12450- Leu Ala Glu Ser Leu Ser Ser Asp Pro Glu Va - #l Leu Leu Gln Ile Asp# 12605- Gly Val Thr Glu Asp Lys Leu Glu Lys Tyr Gl - #y Ala Glu Val Ile Ser# 12801270 - # 1275- Val Leu Gln Lys Tyr Ser Glu Trp Thr Ser Pr - #o Ala Glu Asp Ser Ser# 12950- Pro Gly Ile Ser Leu Ser Ser Ser Arg Gly Pr - #o Gly Arg Ser Ala Ala# 13105- Glu Glu Leu Asp Glu Glu Ile Pro Val Ser Se - #r His Tyr Phe Ala Ser# 13250- Lys Thr Arg Asn Glu Arg Lys Arg Lys Lys Me - #t Pro Ala Ser Gln Arg# 13405- Ser Lys Arg Arg Lys Thr Ala Ser Ser Gly Se - #r Lys Ala Lys Gly Gly# 13601350 - # 1355- Ser Ala Thr Cys Arg Lys Ile Ser Ser Lys Th - #r Lys Ser Ser Ser Ile# 13750- Ile Gly Ser Ser Ser Ala Ser His Thr Ser Gl - #n Ala Thr Ser Gly Ala# 13905- Asn Ser Lys Leu Gly Ile Met Ala Pro Pro Ly - #s Pro Ile Asn Arg Pro# 14050- Phe Leu Lys Pro Ser Tyr Ala Phe Ser# 1415- (2) INFORMATION FOR SEQ ID NO:79:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 87350 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79:- TATATTATGG CTATTTTTCT TTCTTATCTA TTTGTATTTT TATTGTTATT AC - #CTAAAAAA 60- AAATTTTCTA TGTCTTATCA CTAATTCTTC CCTAAAATTT CCCACAATTG TG - #TAAACTTA 120- CCTCAGTATA TTCATAGATA TGAGACATTC TATCAATTTT ACCCTCTTAA AG - #ATGCAGAA 180- ATAATGCATT ATGTTTCATC CCACCATCTT TAATGAGAAG CTTCCATCTT AG - #ATTAATAT 240- TAGAGAATGT TAAAATACTC TGCAATCAGG TAAGGACGCT TGAAACTTCA TC - #ATAATGCA 300- AAAGTTTTCT TTAACACAAT AAATATTTTG AACCCCTTTT GTGTCTTGTA TT - #CATAGGAG 360- TTCAGATAGA CCACTTTATT TACTATTTTT TATAGAGAGT GAACAGAAAT CC - #CATTTCTA 420- GTCACCAGTC CTTAATCTGT AAATCAGGCA GATAATCTGT AAATGATTGG TT - #GAAATCAC 480- ATTGAATTCC ACTTTGTGCC AGGGACTTAA GTTAACGAAC AAATTATTCT TA - #CAAAAAGG 540- TATAAATGTA AGGTTTTCAT TCCGCTAAAT ATGTTTGTCA AACTGTGTTG TG - #ATTTGTTC 600- TCAGTGTGTC ATAGCTACCA TAGCTTTTGG AATGGGCATT AATAAAGCTG AC - #ATTCGCCA 660- AGTCATTCAT TACGGTGCTC CTAAGGACAT GGAATCATAT TATCAGGAGA TT - #GGTAGAGC 720- TGGTCGTGAT GGACTTCAAA GTTCTTGTCA CGTCCTCTGG GCTCCTGCAG AC - #ATTAACTT 780- AAATAGGTAA AAAAAATTTA TTGTTTTTAC TCTTGCAGAT TTCTTTCTTT CT - #TTCCATAT 840- AAACCTCAAA AGTGTTTGAG GCTATTTCCA GTATCCCAAG TAATTTGTGA GT - #GCATTTAA 900- AGTAAAAAAA AAAAAAAAAG AAAAATAAAA CCTCCCCAAA TCCAGAGGAC AT - #GTAAGAAG 960- AACATTTGTG GTAAGAGTTG CCACTTGGAG ATGAGCTAAT TTCAGCATGC CT - #TAGTTAGT1020- GTGAGGAATT AACTAAATCA GGACAATACT TGGGCCTGTC ACAGAGATCC TA - #TGGAATAC1080- TTTCCTACCA TTGTGCATTA ATGAACAGGT TCTTTTCCTC TCCTCAGATC CT - #GTCAAGTT1140- GCGATGTCTT CAGCCATAGT TACTTCAACT ACCACTGATT TTGTTACTGA TT - #CTTTCTTC1200- CCATGCTACA GTGGTGATTA TTCCAGAGGA TTTCTCTCAG TCCCTATTTG AC - #TCTTGTTA1260- CTATTTGTTT TCTTGGTTAG TTCCATGAGA CCATGCCAGT TCTCCTTGAC TG - #TGTATGAA1320- TCATTGTGTT GCACTGTACT GACAGACTGC CGTAAGTCAA TATTAAGTGT TC - #AGTATCTA1380- AGTGCAGGAG AACCTTTCTA CTTAAGTACT CAACAAGTAG TTTGTTGGCA CT - #TAAGTTCT1440- ATGAGATTTT TTGTTGTAAA GGAAAACATT ATCTTGCAAA GATTTTGGGG CA - #GCATTTAC1500- CAATACTTTG TTCCTTCATC CGTAGGAAAA AGAATCTCAG GAGAAAAACC TA - #TACATGGT1560- AACCAATGGG GCTGCCAAGC TGATGAAGTA TTTTCAGAGT ACACCTTTGT GT - #AGCTGAAT1620- AAATTGAGAT CTTGAATGGA CATATTAGCT CATTTTAGTA AAATGATAAG AG - #AGTGCCTC1680- CCACTACAGT TTTTGTTTTT ATGCATCATT AAACAATGTG TTTTTGATTG TC - #CACTGTGT1740- TCCATGAACT ATGCTATGTG TGGGAGATAT AGTAGTAAAG AAAAGCAAAG TA - #CCTGCTTC1800- CATAGAATTC AGTATAATGG GAATGGTAAT TCTTTAGAGA ATCACATAAC TA - #TGGATACA1860- TAGGCTTCAT TTTACTGTTC TCCTTTTGTG TTTGAAAATG TCAACAATCA AA - #ATTTTGTA1920- AAAAAGGAAT CATGCAACAT ATTTAAAATT ATAACTGTGT TAAGTGTAAT GA - #AGGGAAAT1980- TGCACTGAGT AGTAAGAATA TATAATGGTG TGTGGTATTT CCCAAGTTAA AA - #AGGTCAGA2040- TAAGGCTTCC TTGTGGAAGT GATAGTTCAA ATCTGAAAGA AGAATAGGAA TT - #AATTAGGT2100- AAAAATGTTT GATGCAAATT TTAAGATTTT CCTTCTGAGT AGTCAGTAGC TT - #TTCCTTCT2160- TAACATAGAA GATGACAAAA CCATCCTTTT TTTGTACATA ACAATTCTTG TT - #TTCCTTTA2220- GACAGTTGTA TCTGTCAAGC TTCTTATGAT CTAATTTAAA TAATTGGGAT AG - #AACACAGC2280- TGTACATGTT ACTATTAAAT ATGGAATATA TCAAACATAA GTTGATTCCT AC - #CAGTTCTG2340- ATTTTATTTG TGTATTTTGT TAAAGGTACT GAGGACATTA ATATCCAGTT TT - #ATATTGTG2400- CATTTGAAGG TTCATCAATA AATACAATTC TTGTTTCTCT GGGTCTTAAA AG - #ATATTTTA2460- AATGGTTATC TCATTAAGAT TTAACAGGAA ATAACAGTGA TTCAAATCAA AT - #AGTGGTGC2520- CAGAAACCCA TACTTGAATT TTGGGTATAG ACAGGTTACC CTTTGCATCA AT - #CCTGAGGA2580- AACTAAAACT ATAGGATTAA TCAGGATAAA AAAGAATTGA GCAAGGATTC AG - #GAGGGATC2640- TGTATCATCC TGGTGACAAC CCTCTTCTAG AAAAAACTAG AAAGTCTAAG AA - #TAAATGAA2700- GTTGCTGGTT CTCACCTGGA AAGGTCAGTT ACTCACAAAA TTTTTAGAGT CT - #ATCTTATG2760- CCATAATTCT ATCACTGAGA GAAGAAACTT GTCCAGTCAT CATGTAATCT TC - #ATGTAAAT2820- TTATGTTTTT AATTGCAGAA TTCATACCAC AGGCAAAGTC CCAATGTCTG CA - #TTTGCTGT2880- TACCTTAAAT AGTCAAACCC CAAAGTTATT GTAATCTTTT TTTAACAGAG AA - #TAATTTGC2940- AGAGTAATCT CGGTCCGGTA GATCTTTCAG TGGATCCCAA ATGATTGCCA TG - #AATGGTTT3000- AGAATTTTTT TAATTTTCAA GTTGTTTTTA TTCTGTGGAA TACTGGCTTA TT - #TTTGTAGT3060- CCCAAAAGAA AAATAAATAT TTATTTATTT GCCGTTAAGA GTTGTAGTTT TG - #TTTTCTCA3120- AATTTGTCCT GACACTGACG AGATTAGTTA AATGTAGGTC ATCTGAACCA AA - #TACAAGGA3180- AGGAAGGACC CAGTTCTGAA GAGTGTGGGC ATTTCTTTTC TTGTTTTTTT TT - #TTTTTTTT3240- TTTTTTTTTT CTATAGGAGG GGAACGAGGT GAACTAAACA AACAAAATAA AG - #CAAAAAAG3300- AACTGATTTT TATCCCTTGA GGTAGAAAGA ATGAGATTAC AGTGGACCCC CT - #TGTCTGCA3360- TTTTCACTTT CTATGTTTTA GTTACTCACA ACCACGTCCA AAATGTTAAA TA - #GAAAATTC3420- CAGAAATAAA CAATTTATAA ATTTTAAATC AGTGGTGGCT TTGAGTACTG TA - #ATGAAATT3480- TTGTGCCATC CCACTCAGTC GGCCTCGACT TCCCTTAGAA TCATCCCTTT GT - #CCGGTGCA3540- TTCACGTTGT ATTTACTCCC TGTCTGTTAG TCACTTGTTG CAGTATCACA GT - #GCTTGTGT3600- TCAAGTAACG CTTATTTTAC TTAAGAATGA CCCCAAAGCA CAAGAGTACT GT - #GCCTAATT3660- TATAAATTAA ACTTTTTCAT AGGTATATAC ATATAGGAAA AAACATAATA CA - #TACAGGAT3720- TTGGTTGGTA CTATTCTGCG GCTTCAGGCA TCCACTGGAC GTCTTGGAAT GT - #ATCCCTTG3780- TGGATAAGGA GGAACTGTAT ATGGTTAACC TAGGAGCTAG AGTCAACAGT TG - #GAAGAGAC3840- TTTGGGGATA ATTACATGGA AGGGCATGGT GGGTGGTCGT TTCAGATGAC AA - #GAATGTTT3900- TTGAATAACG GATCATTTGT GTCTTCAGAC TTTCCAGAAC TCCTTGAGAA TT - #ATGCAGAG3960- GTATTTAATC AGTCAGAAGG TTGAATAGTC AAATTATTAG TGAGTGAAGT CT - #ATTTTGAT4020- GAGGATTTTA CTAATGCTGT CCCTTAGATG TTATAAGTAA ATCGTTGTTT TC - #TTTTGAAA4080- TATCTGAAAC CTAGTTAACA TGGACTTTCA TTTGTTCTTG TAAAGATATG CA - #AAGCTATT4140- TGGGAGATTG TCATCATCTG ATATTTGATA TTCATGGGCT TTCTTCACAG AA - #GACTAGAA4200- ATTAACAGAG TCATGATGAA TTATGGCTGC ATTGACTTTA AAAAACAAAC AC - #CTCCTTAA4260- TGTTATTTAA CAATTTTGAA TAAATTTGAT ATGGCAAACA AATCAGTTAT AA - #TCGATTGA4320- GAAAGGAACT TAATTCTAAT ACTTGACTGG TGTCCCATAA TAACCCATAA TA - #CTAAGAGA4380- CAGTTTTGGA GGGCGAGAAG TCCTGAAGAG CTGATAGAGA TAAAGGTTCA AA - #TTTGAGCT4440- TCTTTCAGTG TTCCTTACGT CAATGCTTTT AGTTTCTCAT ACAAAATAAA AT - #AAAGAATA4500- ACCTTTTTAC TGGGAAAAGG TAAAAATTAA TAAATTGTAG AAGCATTGTT TG - #AAGCCAAA4560- AAGTGTGTGA CATGTAAATT GAAATGAAAA ACCTTAGAGT TTTTGATACT TT - #TTCAAAGC4620- AGCTAAAGAA TTGATACTTG GACACAGGAA GAATTTTTTT TCAAAAGCAA TT - #TTTATAAA4680- ATCAGAAAAA TGTTTACCTC TTGTTGGGGG CATTGACTGG AAAGGAATAC AA - #CAGAACTT4740- TCTGAGATGC TAGAAATGTT TTTTTATCTT GATGGGGTGT GGGTTTTGTA GA - #TAATGAAA4800- AATAAACAGT AAAAAATAAG TAAAAAAAAA AGTAAGAAAG TTGCCAATAC AG - #TTTTACAT4860- ATTCCTGTGA TGTTTTTAAT CGACAGGCAC CTTCTTACTG AGATACGTAA TG - #AGAAGTTT4920- CGATTATACA AATTAAAGAT GATGGCAAAG ATGGAAAAAT ATCTTCATTC TA - #GCAGATGT4980- AGGAGACAGT ATGTATTATT TATTTTATGC CAATAGTATG GATTTATGGA TG - #ATGCTCTT5040- TTAAGACAAC AATTTGGCTA AATAATTATC AGTATTTTGA AAAAATATTT TG - #TTGCTGTT5100- ACATGTGTGC TGAATTTTTA AGGCTAACTT CTTTGTGTCT GAGTAAACTG AA - #GTCAAATA5160- ATGAAGTCCC AAGTGAATCA ATTAATGGTG ATTTTACCTC ATTATTTTCA GG - #AATGAACT5220- TAACATATAC GTTTCTGTTC TTTTATTTAA TTTAAAATTT TGTCTTGGGT AG - #AATCATCT5280- TGTCTCATTT TGAGGACAAA CAAGTACAAA AAGCCTCCTT GGGAATTATG GG - #AACTGAAA5340- AATGCTGTGA TAATTGCAGG TCCAGGTAAA GATTTCTTAT TATAGATGGA CA - #TTCTAAAA5400- GTCTTTCTTT CTCTTCCTTT TCATGTTTAA CTGAATTTTT GTTGAATGAT AA - #GTATTTCA5460- GTTTTTTAAA CAAAACAATG AATGTGTTTA GATATGAGAA AGCAAACAAT AT - #TAAAGTAT5520- TTTGCTTAAA AAATAGATAA AGCAATAAAA TGGTAGCCCT AAATCTAAAC AT - #ATCAATAG5580- TTATGTTAAA TGTAAATGAT CTAAAATATT ATTTAAAGGC GTAAATTGTA AG - #AATTGGTT5640- TAAAAACATG ACCCTGTTCT GTACGTTGTC CACAAGAAAT CCACTGTAAT TA - #TATAGATA5700- GGTTTAAAAA AGAATGAAAC ATTACATTCC ATGAAAACAT TAATCAAAAG GA - #AGTTGGAG5760- TTACTTTAAT ATCAGACAAT GGACACTTTG GAGCAAAGAA TATTATCAGG AT - #AAAGAAGG5820- ATATTATATG ATGTAAAAGA ATCATTTCAC CAATGTATCA GTCAGGGTTC AC - #CAGAGAAA5880- TAGGACGATT GATATTATGG AGATATATAT ATATATATAT ATATATATAT AT - #ATATATAT5940- ATATATATAT ATATATATAT ATGGGGAGGG AAAGGAAGAA CAAATATGGG GA - #GAGAGGGA6000- TGAGGCGACT GATTTTGAAG AATTAGCTCA CGAAATTGTG GGGGTTGGCA AG - #TCTGAAAT6060- TTGTAGAGCA GGTCAATAGG CTGGAAACTC AGGCAAGAGG TGATGTTGCA GT - #CTTGAGGC6120- AGAATTTCTT CTCTAGCAAA CCTAGTTTTT GCCCTTTAGT CCTGCCACTG AG - #TGGATGAG6180- GCCCACCCAC ATTATTGACA ATAATCTCCT TTACTTAAAG TCAACTGATT AT - #AAATGTTA6240- ATCACGTCTA CAAAATATTT TACAGCAACA TCTAGATTAG TGTTTGACCA AA - #CAACTGAG6300- CATCATAGGC TAGCCAAGTT GATGCATAAT ATTAATCATC ACAACCAAGA AG - #ACATCATC6360- CTAAATATAT ATATATATCT ACTTAACAAA AAGACTGACA GAACTGAAAG GA - #GAAATAGA6420- GAAATCTACA GTTACATTTG GTGACTTCCA GCATCTCTCA ATAATCAATA AA - #ACTGACAG6480- ACCAAAAAAT CAGTAAGAAG ACAGAAGAAA TGAACAGGAT TATCAGCATG CT - #GGATCTCA6540- TTGACCTTTT TAGAACATTC TACCCAACAA CAGTAGAGTA CACATTCAAG TG - #CAGATGCA6600- GTATTCATGA ACATGGATTA TATTCAGAGT CATAAAACAA ACCTTAACAA AT - #TTAAGAAT6660- CTTGTATTTG TATATTTTTT GACTAGAATG GAATTAAACT AGAAAACAAT AA - #CAGAAAGA6720- TAACAGAAAA GTCTCTAAAC CTTAGAAATT AAATAACACA CTTATAAATA AA - #TCCATGAG6780- TCAAAGAGGA AGTCTCAAGG CAAATCAGAA AATGTTTTGA ACTGAATGAA AT - #GAAAATAC6840- AAAATGTGTG AGATGCAGCT AATGCAATAC TGAGAAGGAA ATTTATAGCA TT - #AAATACCT6900- ATGTAATAAA AGAAGAAAGG TCTCAAATCA GTACCTAAGC TTACATCTTA AG - #CAACAAGC6960- AAATAAGAGC AAAATAAATC AAAATGAAGT AAACATAAGG AAATAACAAA GA - #ACATAAGT7020- CAATGAATAG AAAAGCTATG GTCATACCAC TGCTGTCCAG CCTGGGTGAC AG - #AGTGAGAC7080- CCTATGTCAA AAAAATTTAA AAACAAAGCA GCATGCAGCA TTCATTGTCA GT - #GAATAGAA7140- AATGGGAAAA CAATAGAGAA AATCAACTCA AAAGCTCATT CTGTATAAAG AT - #CAACAAAA7200- TTGATATAAA CTTCTAACAA GACTGACGGN AAAGANGAAA AGACACAGAA GA - #CCAATACC7260- AGGAATGAAA GAGGGAATTT CACTACAGAC CTCCCAGGTA TTACTAGGGA TG - #ATAAGGGA7320- ACACTATGAA CAACTCAGAA CATAACTTTA ATAATTTAGA TGAAATGGAT CA - #ATTTCTTG7380- ATAATCTCAA GCTAATTAAA CTTACAGTGA ATTAGATAAC CTGCATAGTG TT - #ACAACCAT7440- TAGAGGGATT GAATTCTATG TTAAAAATCT CTGAAAATAA AATCCCCTAG CC - #CAAAGAAT7500- TTCAATGACA AATTCTACCA AACATTTAGA AGACAAAATA ATACCAATTC TA - #TAGCATGA7560- TTCCATTTAT ATAATAGTCT TTGAAACATA AAACTATACT AGAGGGATGA AG - #AAAAGATC7620- AGTGGTTATT AGAGATTGGG GGAGGGAGAA GGTATGATTC CAAAGGATAG TA - #CAAGGCAG7680- TATTTTGGAG TGATAGATTT ATCGTGCCCT GATTGTGATG GGAGTTAGAT GA - #ATCTATGG7740- ATATCTTAAA ATGTGTAGAA CTTTACACAT ACATACAACC AATTTGCCTA TG - #TTAATTGA7800- AAAAATAAAA TAAAAACAAA TTATTTACCT GGTGGGTTAG CTACGTACCT AA - #GTTCAATA7860- GCTGCGTTAC TGTAAGACAA AAGAAGCATT ATTAGGGATG GAGTTGTTNC TC - #TGTGTAAT7920- GACAAATACT TCCTTCACTA AGAAGACAGA ATTGTTTTAT GCACCTTTAA AA - #AAAAACAA7980- AAACAAAAAA AATACAACCA ACAAACAGTA ACTTGCTGGT GCGGTGGCTC AC - #ACTTGTAG8040- TATTAGCACT TTGGGAGGCT GAGGTGGGAG GATCACTTGA GACCAGGATT TT - #TAAGACCA8100- GTCTGGGCAA AAAACCGAGA CTGTGTCTCT ACAAAAATAA AAAATAAATA AA - #AAAAATTA8160- GCTAGGCATA GCATTATGTG CCTCTAGTCC CAGCTACTCT GGAGGCTAAG GT - #GGAAAGAT8220- CGCTTGAGCC TGGAAGGTTG AGACTGCAGT TGCAGTGAGC CATGATGGCA CC - #ACTACACT8280- CCAGGCTGGG CATCAGAGTA AGACTCTGTC TCACATAAAA AAAATAATAA TA - #ATGATAAA8340- AACTAGTCTG GGCATGGTGG CTCACACCTG TAGTCCCAGT CCTTTGGAAG GC - #CGAGGCAA8400- GAGAATTGCT TGAACCCAAG ACTTTGAGAA CAGCCTGGGC AACATAGCAA GA - #CCCCATCT8460- CTATTTAAAA AAAAAAACAA ACTTAAAAAT CCAGCAAATA CATAAAGCAC AA - #AGCCGACA8520- GAAGAGGTGG AGAAATCAAC AAATCCACCA TCAAAGTGGG AGAATTTGAT AT - #AATTTTAA8580- GTTATTGGTA GGGTAAACAA TCCAAAAATT AGTACACTGT AGAAAATTTG GT - #CAACATAG8640- TAATAAGTTT GCTTATTACT ATTTATCAGT ATACATAGTA TACTGATTTA TC - #AGATACAT8700- AGTATATGGA GCCCTAGAGC AAGCAACTAT AGCAGTGTAT CTCAAGTATT TT - #TACTTCAT8760- GACCCACATA GCAAATGATA TGTGTATATA ACACACTGGG CTAATTGTCA GA - #GTTCAGTT8820- TCTGTCCAAA ACCCTAAGAT CTGGAGTGAT TAACCTTTCA GCACTCTTAG AA - #CTCACTTG8880- TTTGTAGCAC ACTGATTGAG AAGCACTGAA AGACTTCACT CCTCAAACAT AC - #ATGGAATA8940- TTTCTAAAAA CTATGTATTG GGCCGGGTGC AGTGGCTCAT GCCTGTAATC CC - #AGCACTTT9000- GGGAGGCCGA GGCGGGTGGA TCCCGAGGTC AGGAGATCGA GACCATCCTG GC - #TAACATGA9060- TGAAACGCCG TCTCTACTAA AAATACAAAA AATTAGCCGG ATGTGGTGGC GA - #GTGCCTGT9120- AGTCCCAGCT ACTCGGGAGG CTGAGGCAGG AGAATGGTGT GAACCCAGGA GG - #CGGAGTTG9180- CAGTGAGCCG AGATCGTGCC ACTGCACTCC AGCCTGGGCA ACAGAGCGAG AC - #TCTGTCTC9240- AAAAAAAACC AACCAACTGA ACAAACAAAA AAACTAAAAA ACAAAAACAA AA - #AAACTATG9300- TATTAGAGCA TGGGTTGGCA AACTATGGCC TGTAGGCAAA TCTGCATGCT GT - #TTTATTTT9360- TTTTATTTTT TTGACATAGG GTCACTACAG GCTGTCACAC AGGCTGGAGA GC - #AGTGGTAT9420- GATCATAGCT CACTGTAACC TCAAATTCCT GGGCTCAAGC AATTCTCTTG CC - #TCACCTCA9480- GCTTCCCAAG TAGCTACAGG CATGCACTAC CAGACCCAGT TAATTAAAAC AA - #ATTTTTTT9540- TTGGTAGAGA CAGTCTCAGT ATGTTGCCCA GGCTGGTTTT CAAACTCCTT GC - #CTCAATCA9600- GTCCTCCTAC TTCAGCCTCC TAAAGTGCTG GGATTATAGG CCTGAGCCAT CA - #CGCTTGAC9660- TAATGTTTTT GTAAATAAAG TTTTCTCAGA ACACAGCCAT GCCTTTTGTT TA - #TGTGTTAT9720- GTAGGGCTGC CTGAGTTAAG TAGTTGGCTA CAAAGCCTAT CATGGCCTAT AA - #AGCCTGAA9780- ATACTTACTA TCTGGTCCTT TATAGAAAGT GTTTTCTGAC CCTGTACTAG AC - #TAGCTTGT9840- CTCAAAATTC TTCAATGAAT TTGGAAGTTT TCTCACCACA TTTTCTGACC AT - #AATGCACT9900- TGAGTTAGAA GTAAATAAGC AGATAAACAA CAAAATCCTC ATGCATTTGG AA - #ATTAAAAA9960- TAACACTTAA ATAATTCATA TTCAAAGAAA AAATCAAACT GGAAATTAAA AA - #AAATTTTA10020- AACCTACAGA TAACTACATT AATATGCATT AACATTTTTA GAACTTAGGG AT - #AGTTACAA10080- TGATATACAT TAAAACTGGT AAGAGGCTGG GTGCGTTGGC TCACGCCTGT AA - #TCCCAGCA10140- CTTTGGGAGG CCGAGGCTGG GGGATCACGA GGTCAAGAGA TTGAAACCAT CC - #TGGCCAAC10200- ATGGTGAAAT CCCGTCTCTA CTAAAAATAC AAAAATCAGC TGGGCGTGGT GG - #CACGCGCC10260- TGTAGTCCCA GCTACTTGGG AGGCTGAGGC AGGAGAATCG CTTGAACCTG GG - #AGGCGGAG10320- GTTGCCGTGA GCCGAGATTG GGCCACTGCA CTCCAGCCTG GCGACAGAGC GA - #CACTCTTG10380- TCTCAAAAAA AAAACAAAAA AAAAAACAAA AAAAAAAACT AGTAAGAGGT CC - #CAGTGGCT10440- CACACCTGTC ATTCTAGCTC TTTGGGAGAC TGAGGAGAGA GGATCAGTTG AG - #GCCAGGAT10500- TCAAGACCAG TCTGGGCAAC ATAACGAGAC CGCATCTCTA CAAAATTTTA AT - #AACAACAA10560- CAAAAAAACT GGTAAGAGGC AACATTGAAT AGTACTTTGT GGGAGTTTAT TA - #GCTTGAAA10620- TACTCATAAT AGAAAAGAAA ATTAATCAGC TAAGCATCTC ACTAAAGAGA TT - #AGGAGAAT10680- AAACCTAAGC ATAGTTTTTT TCCCCCAAAC ATTATTATAT CTGGAATATT GA - #ATGCATTC10740- TTATTGCTAT TTCAAAGATA CTTACTCTAA GGAAAGCAAT TGAATTAGGT AG - #TTGAACTC10800- TATAGTAGAT TTTCTTTAAT GAGTCCTTTT GTTCTCAACC TACTTAAATA AT - #TCTCATTT10860- GAATTTATGA TAGTTTCAGA TCTACCCAAA GGGTGACTTA GGAATTTAAC TT - #CTAAATCT10920- ATTTAAATGA AAGGTTTATA ATCTTTGTGT CATATTTTAC AGTCGTTAGC GT - #TTAACAAT10980- TTATAGCATA GGATTTGGGT TTTTTTTTTT TTCATTTTAA AGAAGAAGTT TA - #TTTAAGCA11040- AGACACTTGA CTAAGGGAAG ACTATCTTGG AGTTATTATT ACTAGAGTAA TT - #TATTTCTA11100- CTTAAAGACA GATTGCCCCA CAAGTAACAG CTACATAAAA AACAGTTGTA AA - #ATTGTCCT11160- TGGTTTTACA ATGATAAATG AAAAACATTA AAATTCTCTA ATTGAACAAG GT - #ATGCAAGG11220- ATTTTTATAT TGTTTTTTGC TAAAACTATG ACAGCAAAAT AACATCCTGG AG - #TATAAAGA11280- TAAGAGCTGA ATGAGCAGGC CACTAGGGGA CAAAGGGAGT CTTTTCACAG AA - #CCAATGCT11340- TCTTTTGCCC ACCCCATCTC CATCGAAGTC AATCTAAACA TATTATTGGC CA - #TTTAGTTA11400- AAAAAAGAAA GAAAAGNAAA AGCAATATGC TTGTGGACAT ACACCAGTTA CT - #TTATGTGC11460- AATAAAAGAG TAGGAAGGGG AAGGTGAAAG AATAGAGAAA ACTATGTAGT CA - #GGATGTGG11520- TGGAACCAAA TTGCAACTTT CTTTTTTTTT TTTTTTTTTT TTTTTGAGAC AG - #AGTTTTGC11580- TCTTGTCACC CAGGCTGGAG TGTAGTGGTG GCCCAATCTT GGCTCACTGC AA - #CCTCCGCC11640- TCTCAGATTC AAGCCATTCT CCTGCCTCAG CCTTCTGAGT AGCTGGGATT AC - #AGGTGCAT11700- GCCACCATGC CTGGCTAATT TTTGTATTTT TAGTAGAGAT GGGTTTTCAC CA - #TGTTGGCC11760- AGGCTGGTCT TGAATGCCTG ACTTCAAGTG ATCCACCCGC CTCAGCCTCC CA - #AAGTGCTG11820- GGATTACAGG CGTGAGCACT GCGCCTGGCC AAATTGTAGC TTTCTAATTG AG - #ACTGTCTT11880- CTTGGTCTGG AAGAGCAGAG TTCTGCAGTA AAATAACAGG TCCCCCTTTT AG - #TAGACATC11940- TCCATGTCTG CTGCTGGAAC ACATCAGTTT TGTCTTAAGC CTCACTTCCA AA - #TGTGCAGA12000- TGTGTCTGGT TCATTGATTG GCTGCCTGTC AAATTGAAAC CTGATCTGCC TC - #ATTGGCAA12060- ACCGTGCCCC TTACAATAGG CTTTCATTGG TTTACTAAGC GGTGTGGTGC GT - #GGCTGTTC12120- ATCTTAAACT GCACCACAGT TTAAGATGAA CCTTCAAATG AACATTATCC TT - #GTTCTCAG12180- TCTTGACTTT CCTTGGGCTT TTTGTGGACC CTGGTGAGTG TGGCAGTCTC CT - #CAGCTGCT12240- GCTTCACAAA AGAGGTACCA GGTCTGCCCC GAATGAGTGA GCCCCTAAAC AG - #GACCAGGA12300- GTGGCAGAAG AAAGAGGCAG CAACTGAGAT GTGTTTTTTC TAAGCTGAAA GG - #CTTTTTTT12360- TTTTTTTTTT GCAACACACC TTTAACACTA AAGTCCAATA TTTATATAAT TN - #GGTCAAGT12420- AAGTGGAGCT GTTCTAGCTA TAAATATGGC AACTCTGCTT GCTCGTCCTA TT - #ATTGACAT12480- TATTCCTTTC TGTGGTCTGA GGTGCCTCCC ATGAAACTTG CTTCTAGGAC AC - #TAGGATTG12540- AGAACCATNC AGCGTAACAT ATCTGTTACG CTACAATAGT TTATTTTCAT AT - #TTTAGCTA12600- CTTTACATAC TCGGGTATAA TGAACTTTAT TCATAGCTTC TGAAGCAGTT GG - #CACATTTG12660- AGATATTTTT TACTTGGCTA ATTGTTATGC TAAATCTTTT GATTTCTAAA GA - #TACATGCC12720- TTTGCTAAGC TTTCTTCAAA TGTTATTATT TTTATTTAGA TTGGATCATT GC - #TATTCCAT12780- GGATGACTCA GAGGATACAT CCTGGGACTT TGGTCCACAA GCATTTAAGC TT - #TTGTCTGC12840- TGTGGACATC TTAGGCGAAA AATTTGGAAT TGGGCTTCCA ATTTTATTTC TC - #CGAGGATC12900- TGTAAGTATA TATCTGTGAA TTCCCTTCAT AGATCTTCTT TTACTTCTAT TA - #CACTTTTC12960- TTCAGAGGTT TGCAGTATTA TGATTGTAAC TTTGACTTCA GATGGGTGAC TA - #GGAACTCA13020- TAGAGTCTTA CTAAGTTCCA GTTAAACACT ACATTCATTA CTTTGGATAA AA - #CCCGTGTG13080- TATGGCATCT TCTGCTGTTT TCATGTTCAA GCCGATGTTC AGCTCTGCAG CT - #CAGTCTGG13140- AAGCATTGTG TTAATTTATC ACATTGCATT TGGGTGAATC CCTAGACTAG TC - #TTGCTTAG13200- GATAATTAGG AAAAGTTAAC TTTCATTGTA TCAAGGGACA GGTAGAACAA AA - #TTGTCCTT13260- TTGTCCAGGA AACTATTAAA TTCTTCAAGG AAAACTTTAG TTATAGGGAT TA - #TTTTTTAA13320- ATGTCTAATT TCAGTAACAA TATTTGGGAC ATATTTATTT TTCCTTCTGT TT - #CCTATCAG13380- AAGTATTTAA AGTTATAAGA AAATTGTGGT TTTTGCCTTT ACTAATGAAT AA - #ATAATCAA13440- TTAAATTCAG TTACTTTTTT TTGGAGTGAT TGATGTTCCA GTATTCTTCT AA - #ACAACCAC13500- GGGTACAAAT GTGAATAAGA TAGGACCGTT GCAGTCCAAG AGCTTGTTCT GT - #AGTCCTTT13560- CCTTTATATG ATTTTTTCCC CTGATTTAGA AGTCTATAAA GCAAAGCTAA GT - #ATTACACA13620- CTGATAATGG CTGAATAAAT CAAGAGCAAG AGATAGGATA CTTTGCAAAT AT - #GCATATTT13680- ATTAAAAATG TACTTTAAAA TAGAGATTAA AATTCTCGTA TTGAATGTAG AA - #TAGGTAAG13740- CATTTATTTG TGAAATACTC GAATGCTTCA TGTAAATACT TTCTGAGTTT GT - #ATTTTTAG13800- AAAGGAACAT TTTGGAGGCT GAGGCAGGAG AATGGCGTGA ACGTGGGAGG CG - #GAGCTTGC13860- AGTGAGCTGA GATTGTGCCA CTGCACTCCA GCCTGCGCGA CAGAGCAAGA TT - #CTGTCTCA13920- ATAAAAAAAA AAAAAGAAAC ATATTTATTA AATTAGTTGT GAAATATTTT TA - #ATGAAATA13980- TATTGAAAAC TTCTGTTGAT TTTTCATGTA CTGATGTTTT TAGATTCTAA AT - #GGAGTTTA14040- AAATTTTGTT TGTAAATCAC AAGTTGGATT AGAAATTTAA TAGTAGAAGT GT - #TGCCTAAG14100- GACTATTTTA GGTGCTGTGA GTGAAACTGT ATTTTTTATA ACAAGAATTT TA - #GTTGTAAG14160- GGACAGCTTA AATATAATTG AGATCTGTGA AAATGTATTC TGTCTCTATC AC - #CTTCAGAA14220- CCTGTGTATC TCAGTTGAAT GTATAATTTA TAAAAATTAT TCTTGTTTTA AT - #TTGGTGTA14280- ATCCAGCCAT ATCCAGTATC AACAAATAAG TCTAAGTAGG CTCCTTGACA AA - #CTTGAACT14340- GGCCACAAGA GAGATCAGAT TTCACCTATT AAAAAACCAA ATCAGACCAC TT - #ACACTGAC14400- AGTCTCTTCT GGGAGTCCTC AAATTAAGAA GTCTATCCTT TGTGAAATAT TA - #CACTACCC14460- TTGCTAGATA AAACTTTTCT AAAAGTACCA CTTAATGAAA ATCTGTAGAC AC - #TAAATGCA14520- ATGAAAATAA GGCATTGTTT TTTTTTCTCC CCATTTCAGT GATCTTGGTA TC - #CTGGGATA14580- TTGTTTTTAA AATTATCGTT ATAATTCCTT TGAGAATTTA GTGAAACGTT CC - #CTTTAACC14640- AACTTAGGAA AAATTAATAT CTTTGTACAT GATTTTGAGC TGTAAAATAA AC - #ATTTTAAA14700- CTGGGAATAA TTGGAGTTTA GTTAAAGAGA TAATGTATAT AAATATATAA CA - #TAGTAGCA14760- GCATATAATT CTGTCTTACA CAAGATTTTT CTGAATAGTA TAAACAGTTA TG - #TAGCCTAT14820- CTAGGAGTTT GTGAATAGAG TTTAAAATTT TGTTTTGAAG CTGCAAATTT GA - #TTAGAAAT14880- TAAACAGTAA AGTTATTACT TAAGGAACTT CGTTTTAGCT GTCTGAACAA CT - #TACTGTAT14940- AAAAATCTTT AAACATTCTG TATAAATATG TGATAAGATA TGCAATGACC TT - #AATTTTAT15000- AGATTAGAAA ATAAAAACAC ACTCATTAAT TTACATAACT GACAGATTAA GT - #GAAACTTC15060- TCTTCTGATC ACGTTAGCAG AATGCCAAAT CTTGTCGTGG CACTAGAATT AG - #ACGGTAGT15120- TTTGATAATA CATGATTTGA CTATAGACAT TTGTTGAAAC TATTGGTAGT TT - #TAATCACT15180- CTTGTAATTT TCAAACTATC TAACGGGAGA GGATTATCCA TCCTGTTTTC TA - #GACAAACT15240- GTTTCATCTG AATGAAATAT ATTCCTAGAG ATAATTATCA CTACTTCATC TT - #TTGGTTTT15300- ATTTTGCACA TAGAATTATA GTTCACAATG ACTTTCTGAA GCTCTAAAGT TG - #CAGCTGTG15360- AGCTTCTTTG GCCTGTAGGG ACTGGGAAAA AGCACCCCCG TCCTCCCCCA AG - #CCCCCCCA15420- CCAAAAAAAG TTAAAGTGTT TTTAACAATA GCTGTGGGCT TTTTGTAGTT TC - #AGAACTTA15480- GGAGTTGCCC AGGCTGGAAT GCAGTGGTGT GATCATAGCT TGATGCAGCC TT - #GAACTCCT15540- GGGTTCAAGC AATCCTCCCA CCTCAGCCTC CAGAGTAGCT GGGACCACAG GT - #GCCACCCC15600- ACCCAGCTAT TTTTTTTATT TTTTAATTTT TTTGTAGGTA TGGGGTCTCC CC - #ATGTTGCC15660- CTGCCTGTCT CAAACTCCAG GGCTCTCAGG TGATACCCAC CACCCTTGGC CT - #CCCAAAGC15720- ACCGAGAGTC ACTGTGCCAG GCTGAGTTTA AAATTTCTTG AGTTGGAGTT TA - #TGGCTATT15780- TTTTCCACTA GTTATTAAAC ATGTATTTTT GTATAAGGCA CTGTATTACA TT - #TTGTGGGG15840- GGATTCAAAG CTAAATTAGA TGAGACGCAT CATCTATTAT GGAAGATGTT AC - #TTAAGAAG15900- AAATGAGTGT AATGTAGCAG AGAATTAGAT AAGGGACGTA TGAATACATA TA - #AATGCTGT15960- TGAAGTTCTG AAGAGAGAGA GTGTTTAGAG AAATTAGAGG AGTCTTTGTG AA - #GTTATCAC16020- TAGAACTTCC TATTTTTGTG GAATATATAG TAGATTTTGG TGTGATACTG TG - #GATTTGGA16080- CATTCACTCA GAGAAGGAAT GAGGGAAGAA TGGTGGAGAA GAATGGCATT CA - #CAGTACAA16140- AAAGCAACTG TGACTTTTAA AGAAGTTAAT ATGGAGAAGT GGCAAGTCTT TT - #CTTCTCTC16200- TTCTCTTCTC TTCTCTTCTC TCTTCTTTTT CTTTTTTCTT TTTTTCTCTG TC - #AGATACTG16260- TTGTAAAGAC TTTGCTTTTA CCGGAAACTG ATACGTTGGG TCATGTACCC TG - #GCCAGTCA16320- GTTCTCTTTA TTCTAACACT TAGCCGATCA ATTAGATTTC CACATTCCAT GA - #TATGTCAG16380- TTTTGGTGAC CCTTATTTTT CCACCTGGTT TATAAAGGGA AAGAATGTGA TA - #TGTCACCC16440- AGGCTCTGGA GTACAGTGGC ATGATCATAG GTCACAGCAG CCTCAAAGTT TC - #CAGTTCAA16500- GCGATCCTAC CTCCTTGGCT TCCTGAGTAT GTGGCACTAC AGGTGCATGC CA - #CCATGCCC16560- AGCTAACTTT TTTGTAGAGA CAGGGTCTCC CTATGTTTCC CAGGCTGGTC TT - #GAACCCCT16620- GACCTCAAGT GATCCGCCCA CCTTGGCTTC CCAAGATATT GGCATTACAG GC - #ATGAGCCA16680- CTGTGCCGGC CTGAAAATTT CTCTTTTGAG ATGGCATCCC ACAGAAGTAT AC - #CTGCTTAG16740- AGCTAACACT GGTAAAAAGA CTATTTAACC CTATTGCCTT ATTTTACTGT AG - #TTGAGATT16800- GAGTTAAACT GAAAGCTGAA TGACCTGTCC TAGGTCATAC TGTTACTTTG TG - #CCAGAGTC16860- AGGATGAGCA AATGGATTTC CTGCCTGCTA GTCTAGTGTC TTTTCTATTT AT - #TGTGCTGT16920- AACATACAGT TTTAAATTTG TATTTTTATG CCCAATGGAC ATGGTAGCTC AC - #ACCTGTAA16980- TTTCAGCACT TTTGGGAAGC CGAGGTGGGG GGATTGCTCG AGACCAGGAG TT - #CAAGATGA17040- GCCTGGGCAA CATAGCGAGA CTCCGTCTCT ATAAAAAAAA ATTTAAAAAT TA - #GCTGAGTG17100- GTGATGTGTG TGCGTGTAGT CCTCCTTGTG GGAGGTTGAG GTGGGAGGAT CG - #ATTGAATC17160- TAGGAATTCA GGACTGCAGT GAGCCATGAT TACACCACTG CACTCCAGCC TG - #GGTGACAG17220- AGCAATACCC TGTCTCGAAT GAATGAATGA ATGAATGAAT GAATGAATGA AT - #GCCCAAAT17280- CCGTAAGCTA TGTTCTGTAT AGCAGCTTTT TCATCATAGG CAGTTTTTAC TC - #TTATCAGT17340- GGACAACCTA CAAAATTAAC TAAACACTTA AGCAATTAAC AGAGGAGGCC TT - #GTTCAGAG17400- TGAGAAATCA TTAAGCATTT GTTGTTGAAA TTTCTTACTG TACTCTGTTT TA - #ATTCTGTT17460- TTTTTTTTTT TTTAATGTTA CTTGTTTTAG TTTGGATTCC TAGTTGAAAA GG - #GAATATGA17520- TTCCTTTAAA ACAAAGATAC TCTGCTTTAA AGCAAAGGTA TATCATCCTC TT - #CATGGTGA17580- TTGCCATGGA AACAAGACAA TGTAAATTTA TTCAAATAGT ACACAGTTTT TA - #TAGTTATT17640- GATCATGAGG GGAAGGGACA GTTAATCCCT ACTGATCAGA TAAAACCTCA TT - #GTTTCATA17700- CTAATAAATG GTTTTTTTAT GCTTATGAAA GGAAAAGCCA GAAGGGTAAT TT - #TTAGTGTT17760- TAGAGAGCTA GTGATTCTAG TTAGGGAACT TAATACCTTT GAAGTTATTA GT - #TTGCAAGC17820- AATAGAATCT ACTACTACCA AGGTGACCCC TAGCAGATGT AGAGTACCAT TA - #ACAAGTGT17880- TCCAGGGAAG GAAAGCCAAC TAGATACCAA GTCATGCTTT TTACTCTTAG AT - #TAAGAAAT17940- TCAGGTTGAG TTAAAGGATC AGCTGTTAAC TAATAAAAAG CAGATTAATA TT - #ACAGAGCC18000- AGGCTCTGTC CTGGTTATGG ACTTAATCTT CACAGCATCC TCAAGAGATA AA - #AATGAATA18060- TACCTGCATA TTAGATGAGG AAATAGAAGA TAAGTAACTT GCCAGAGCTA TG - #ACGTGAAC18120- TCAGGTAATG TAGCTTAAGA GCCCCCACAT GTATGTATAT TGGGTGTGTG TG - #TGGAGGGG18180- GTGCGTGTGA GTGCTTGTGC ATGCGTGTGG TATAATAAGA AAAAATTAGC AT - #TTATGCCT18240- GTAATCCCAG CACTTTGGGA GACCGAGGCA CGAGGATCTC TCAACCCCAG GA - #GTTCAAGA18300- CCAGTCTAGG CAACATAGCG AGACCCTACC TCTACAAAAA AAGTTTTAAA AA - #TATTAGCG18360- GGCATGGTGG AATACACCTG TAGTCTCAGC TGCTTGGGAC GCTGAGGTGG GA - #GGATCCTT18420- GAGTCCAGGA GATTGAGGCT ACAGTGAGCT ATGATGACAC CTCTGCACTC CA - #GCTTGGGT18480- GACAAAGAGA GACCCTGTCT CCAAAAAAAA AAATTAGAAC TAGTTATCTG GA - #GGCCTGTG18540- TTCTAGTCCT AGCTTTAGTA CGGCTACACA GTGACACATT AGGCTACCAT TT - #AACATCTT18600- TGAACCTCTG ATAATTTGTT AACAATATGG GTAAAAATGA CTAAGATAAA TC - #AAAGAGCT18660- CCAGCATTCC CTCCAGCTCT GAAATTCTAT GATGTTTTAT CTTATTTTAC TT - #ACAAAAAT18720- AAATTATATT ATGTATATTT AAAGTATACA ATTTGATGTT ATGGGTTACC TA - #TAGTAAAA18780- TGATTACTAT AATGAAACTA ATTAACATAT CCATCATCTT ATATTGTTAA CC - #ATTTTTTT18840- GTTTTTGTGG CAAAAGCAGC TGAAATCCAC TCATTTAGCA GGAATCCCAA AT - #ACAGTTCA18900- GTTGTATTAA TTGTAATTCT CATGTTGTAC ATTCGATCTC TAGACTTGTT TA - #TGCTACAT18960- ATGTTTGACT TTTAAACATT CTACTCAAAT CAACCCTAAG TCAGGGTTAG CA - #CAGACAGG19020- ACTTGTTAAC AAGGTAGAAG GTGCCACATT GTACCTGGGT GTTTATATTT CT - #CTAAATCT19080- TGTTCTGATC ATATTTTAAT AAATATAATC ATCAGGACAC CAAAATTCAT TC - #CTTAGCTA19140- TTAAAAAATT CTATTCTATT TTATTGTTAA GATTTAGGAG AGCATGGTAC AG - #ATTCTCTT19200- AACTATACCT ATCAGAAGCC TATGTTTTAA GTCCAATGTA TAGGCACTGC TC - #TGTTTGTC19260- TCTGGTGGGA ACTTACCCTG CTTTACCTAA TTTCATCCTA GCTTCCTTTT TG - #TGAAAGAT19320- CACCCTTGCT TAGCCTATTT TTTGGCAAAT CTACACCTTG GAAATAGTAG TA - #AATGACAT19380- AAGCATATTA ATATTTATGA TGTGATTTAT TTTTGTTTTC AAGTCATATA CT - #GGGGAAGA19440- TTCTCAAATA TTAAAACAAT GTATCTTTAC ATTTATGTAT GTCGTTCTTG TT - #CTGTTTTA19500- GAAGGCTTGT ATTTGCATTT TTAACATTCC AAAAGGTAAA CCTGTAATCA TA - #ATGTTTTC19560- ATCAATTCAA TAAAACCATT ACGTTTGTAA TAGAGAGCCC TATAGTTGCC TT - #AGTTAAGT19620- TTGCTGCAAC TCATTTTATA TATTCTTTTA ATTTTGATCC CTGGATTTTT AA - #TTGATTAT19680- TAAACCTTCA TTAGGATATA TATGAAATGT AAAAATATTG AGTTATAATC TA - #CCGTTTTC19740- TAAAATTTTA TACTGCATTT TTATATAGAA ATTCAAATTG CTCATAATCA TT - #CTAGTGAA19800- TTTAAGTAGA AAGGTATTTA TTACTAGGTA TTAAATGGCT TATAATATTG TT - #GACAAGGT19860- TCCACTGCAA AATAGTTCAC CAAGGGAGCT GTGGCCTCTT CTGTGATCAA GA - #AGCCATCT19920- GTCAACTTGG GAAGCTTCCA CTATAGCACC TAACCCCAGA CTACATTGAG TA - #GGAAGCTG19980- TAATAATCAG GAAGCTTCTA CCTTTGCATG CTCTGCAAAC CAACGTGAAC CT - #GCTGTAAT20040- TTGTAACCAC AAAATGGATG CCTGTTGATA CTTACGAAGC TCATCATTGT AT - #GCTGGGTT20100- CTTTGCTAAT ACTTTCTTAT AAAAATTAAA TACCTCCACA ATCATGCATG CT - #AGCAGAAA20160- CAGCAGAGGA GTAGCCTTAG CCTCACTTCC TGCTTATACC TGTCATGCAG AT - #ATACAGAA20220- CCCAGAACCC TAGCTGAAAG GGAGTTTGAG AACTAGTATT TGTATTGTCC CA - #GATTCTGC20280- AGTGGAAGAA TTCATAGTGG ATGGAAGTTA GAATGACCCT TGAATTACAA TC - #GGCCACAT20340- TCATCACAAA TACATTAAAT AAGAGTAATT TGCCATAAAG CTCTATGTTT GT - #ATACTTCT20400- TTGTTTTTTT TTTTTTTTTT TTTTTTTTTT GAGACAGGGT CTCACTCTGT TG - #CTCAGTCT20460- GTAGTGCAGT GGTGTCATCA TAGCTCACTG CAGTCTTGAT CTCCTGAGCT CA - #AACGATTC20520- TCCTGCCTCA GCTCCTGCTT CAGCCTCCTG AGTAGCGGAA CAACAGGTAC AC - #ACCACCAC20580- ACTTTGCTAA TTTTTTATTT TTTATTTTTT GTAGAGATGT GGGTCTCACT GT - #GTTGCCCA20640- GGATGGTCTC GAACTCCTGG GCTTAAGTGA TCCTCCCAAA GTGTTGGGAT TA - #CAGGCATG20700- AACCACTGTG CCTGGCCCAT ATACTACATA TATTTAAAAG TAGTATTTAA AT - #GTGTAGGA20760- TGAATGAAAG AGGCAGTAAG AGAACAAAGT GAATGAAAAA GTATTTCTAT AT - #GAAGTGAA20820- AGCAGGAGAG TCCTCTCTGT TAGAGAACAA CAGAATTGCA TATGACAGAC TA - #GCTTTCTT20880- AATATTTCTA GAACTTGATG GCTGTGAAGA GCGTCCCGTA GGAATTCTCC CT - #TCACTTAG20940- GAAAACATAC CTCAAAACCA TCAGCTGTTT AGCATGCACC TGCTTTTCCT GG - #TATATCTC21000- AGTGAAGCAG CTAAATTGTA AATGATTAAG TAAACTTTGC AGTGTATCAT GT - #GCAAAAGC21060- ACAGTAAAAA CAAAAATGCA TTGGAAGCTG TGAGTTGTTG CACTGCACTC AT - #GGATGAAT21120- AGCTGTTGGT TCGCATTGCG TTTTTTTGTT TTGTTTTGTT TTGTTTTTTT GA - #GATGGAGT21180- CTTGCTCTGT TGCCCAGGCT GGAGTGCAGT GGCGTGATCT CGGCTCACTG CA - #AGCTCTGC21240- CTCCCAGATT CACGCCATCC TCCTGCCTCA GCCTCCCGAG CAGCTGGGAC CA - #CAGGTGCC21300- CGCCACAACA CCTGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGGGTTTC AC - #CATGTTAG21360- CCATGATGGT CTCAATCTCC TGACCTCGTG ATCTGCCTGC CTTGGCCTCC CA - #AAGTGCTA21420- GGATTACAGG CATGCCGCAT TGCGTTTTAT ATAATTCTCA TGGTTCTAGT CT - #CGAGCTGT21480- AGGATTTTGA TCACTGTTTC AAACAATAAT GTGAGTTTGC TAAGAGGTCT AA - #ATAACAAA21540- AGCTAAGTGT CCAAACACAT ATCCAAACCT ATACACTGGG CAATGCATCT GA - #ATTATATG21600- TGAAATTTCC TGCCATTATT TAAGACACAA AAGGAACATT ATTTTGATAA TG - #TATTTATT21660- TGTGAGTGGA GTGTTCAGAA TGAGCACGAT GGGTATAACA TTTTTGTAGG TT - #TTTAAAGT21720- TGAAATTTAG TGTAAATCCA AAGAATCAAT AGACAAGTCT GTGTTTTACT TA - #ACCTATAT21780- GTTTAAATTA GCATTTTTAG ATACTGATTT TATTCCTAAT TTCAGAATTC TC - #AGCGTCTT21840- GCCGATCAAT ATCGCAGGCA CAGTTTATTT GGCACTGGCA AGGATCAAAC AG - #AGAGTTGG21900- TGGAAGGCTT TTTCCCGTCA GCTGATCACT GAGGGATTCT TGGTAGAAGT TT - #CTCGGTAT21960- AACAAATTTA TGAAGATTTG CGCCCTTACG AAAAAGGTAA ACAGTGTAGG AG - #TCTGCCTG22020- TTTGACTTAA TTTTGTTTCC CACTCCACAT TAAAAGATCC TTTTTGCTTT TA - #ATAGGGTA22080- GAAATTGGCT TCATAAAGCT AATACAGAAT CTCAGAGCCT CATCCTTCAA GC - #TAATGAAG22140- AATTGTGTCC AAAGAAGTTT CTTCTGCCTA GGTTCATTTT TCAGTTTTTT TC - #TTGTAACT22200- TCTGCATTTT TTGTTGCTAT TTATGTGATT CAAATTATAC CAGTTTATAG GC - #CTCTCACA22260- AGTAAAATGA ATTGCCTGTT TGTTTTTGTA TGCCTATTTT AGTCAGTTTG GG - #GGAAGGGA22320- TCTGTGAGGA AAGGATAAGT CATAGAGCAC TTTTCTTTTT TAAGAGACAG AG - #TCTCTCTG22380- TGTTGCTCAA GCTGGAGTGC AGTGGTGCGA TCATAGCTTA CTGCAGCCTC GA - #TCTCGTGG22440- GCCCAAGTAA TCCTCAGCCA CCTGAGTAGA TGGGACTACA GACATGCACT AC - #TATGCCCA22500- GCTAATATAT TTTAATTTTT TGTATAGAGA CAGGGTCTTC TAGTGCTTCC TA - #GGCTGGTC22560- TTGAACTCCT GAGCTCAAGT GATCCTCCTG CCTCAGCCTC CCAAACTACT GG - #GATTACAG22620- GCATGATCCA CCGCTCCCAG CCAGAACATT TTCTTGGTTG ATGGGAAGTA GC - #TGACCATG22680- GTATTTAGAA AACTTCTTTC TCATCGATTA AAGAAGCAGT ACTGAAATCA AT - #GCGGAGGA22740- ATCCATATAT CATATTTACT TCTGGTGTGT AGAAGTGGAA AGGGAATACA TT - #TGTTGCTT22800- ACTTTTTTGT ACCTTTACAT GTGATTGATC ACTTGTGAGT TTTTTCTTTC AA - #ACATCTTA22860- AAGCTTCCAG AGCTTTTTCT AGAAAAAAAA ACCAGTTTTA AGAATCACCA GT - #TCTAAAAG22920- GGTAATATCT TATTCATCTT TCTGAGAATG GAGTATCATG ATTCATGAAT TA - #GATACTTG22980- CATCTTAACA TTTGAAATAA TTTAATTTTA TTATTTTTTA GTTCGAAAAC TG - #TATCTTCG23040- GGCACCAAAG AGCATTGTTA TAATCAAGTA CCAGTTGAAT TAAGTACAGA GA - #AGAAGGTT23100- TGTTTTAAAG AAATTGTTCT GACTTATTTC ATTCTTTATT GATTCAAATT CT - #GTTTAAAA23160- TTTTATATTT TAATTCCTTT CCAATTAAAG AGAAAATGGC ATATATAACA AA - #GCATAAAA23220- TTCGGCCAGG GAAGTGATGT GAACAGACTA AAATTTATTG TATATAATTT CT - #GGGGCTAA23280- TAAAGAATTG GAGGTATTTG AGAAAGGAAT TAATTTGGGT TCTTTTAAAC CT - #ATCTGCTA23340- ACTCATTTGG CTTAGAGTAG TCACATGTTA TAATACTTAT AGTTGATCAA AA - #AATTGATT23400- CCTAAGTGTT CTTATTAAAG ACACACACAC ACACACACAC ACACACACAC AT - #TCTTTCTC23460- TCTCTCTCTC TCACACACAC ACACATGCAC ACACACTTAT GTACTTTCTT GC - #TTTTTTTG23520- ACCTAAGATC TTAGATAACT ATTACAGATT AAATACTAAT CCACTGGCAG AC - #TTCAGCTA23580- ATTAGAACAC TGGAATAATA GGCAAGCATA GTGAATTACA TTTTCTGGTG AA - #CTTTTTCT23640- GCTTTATTGA AGTATGCAGA ATGTAAATGA ATTGTTTTTA TAACTTTGGC AC - #TTGCTGTA23700- TCTTAGAACA TTCTTTTGAT GATTTATTTT CTGTAGTTTT GGGAGAGATA AG - #ACATTGGA23760- ATGCGTTTCT AACTACCTTT AGAACTTTAG AAACTGATAA TTTAGGAGGT TA - #TTTTCAGG23820- TGATTAATTT GACAGCTTGA TTAGGCAAAG AAAAAATTGT GATTTTGAGA TT - #TTTGTTTC23880- TTATTTTCTT CACATTTAAA AGTTTTTTGA AACTTTTTTT AATGGACCTT TA - #TATGTTTA23940- AATGCAGTCT AACTTGGAGA AGTTATATTC TTATAAACCA TGTGATAAGA TT - #TCTTCTGG24000- GAGTAACATT TCTAAAAAAA GGTACAGAGT TCCATATTTC TATGTTCTAT AC - #TTGCTTTA24060- TGAGTACTTT TTTTTCTAAA GAGAAAGAAC TGTCAGATGT TGGGCTATTT CA - #TTGGCAAA24120- AGGAAGTTAA ATTTAAAACA TAAGCTTTTC AGTATTAGAA TGATCAAAGT GA - #GCTATAAA24180- AGAATAATGT TAATTTAATA GCTAACACTT CTTGGATATT ACTGTTTGTC AG - #GCATTATG24240- TTAAATGCTA AGAACTTTAT ATGTGATATC TCATTTAATT CTTACAAGAG TC - #TAACAGCT24300- GTTACTATTT ATCGCCATTT TATAGTTGAA GATACCAAGG GTTAAGAAGT TG - #ACAAACTT24360- GTTCAAGAGC ATACAGCTAA TGGCCGAGCT GGCTTTCAAG TCTATATTTG TC - #TACCTCTA24420- GCATCAAGAC ACTATTTATT TTTCTTTGTA TGAAATATAT ACAGGCATAC TT - #TGTTTTAT24480- TGTGCCTGGC TTTATTGTGA CTTGCAGATA TTGCATTTCT TATAAATTGA AG - #GTTTGTGG24540- CAACCCTGCG TCAAACAGGT CATATTAGCC CCATTTTCCA ATAGCATGTT CT - #GTTGTCAT24600- GTCTTTGTGT TATATTTTGG TAGTTCTTGA CTGGCCATTC ACCATTTCTC TC - #CCTCTCCT24660- CGGGTCTCCC TGTTCCCTGA GATACAACAA AATTGAAATT AGGCCAATTA AT - #AACTCTAT24720- AATAGTCTCT AAGTGTGTTT TTTTTTTTTT TCGAGACTGA GTCTCACTCT GT - #TGTTCAGG24780- CTGGAGTGCA GTAGCACAAT CTCGGCTCAC TGCAATCTTC GCCTCCCGGG TT - #CAAGCGAT24840- TCTCCTGTCT TAGCCTCCTG AGTAGCTGGG ACTACAGGCG CCCCCCGATC AT - #GTCTGGCT24900- AATTTTTGTA TTTTTAGTAG AGATGGGTTT TTGCCGTGTT GGTCAGGTGG AT - #CTTGAACT24960- CCTGAACTCA GGTGATCCGC CTGCCTTGGC CTCCCAAAGT GCTGGGATTA CA - #GGTGTGAG25020- CCGCTGTGCC TGGCCCATCT CTAAGTGTTT AAGAGAAAGG AAGATTCACA TG - #TCTCTCAA25080- TTTAAATCAA AAGCTAAAAG TGATTAGGCT TAGTGAGGAA GCCATGTCGA AA - #GCTGAGAT25140- AGGCCAAAAG CTAGGCCCCT TGCACCAAAC AGTTAGTTTG CAAAGGCAAA AG - #TTCCTGAA25200- GGAAATTAAA AATGCTACCC CAGTGAATAA AACAATGATA AGAAAGCAAA GC - #AGGCTTTT25260- TGCTGATATG GAGAAAGTTT TAGTGGTCTT TATAGGAGAT TAAACCAGCC AC - #AACATTCC25320- CTTGAGCCAA AGCCTAATCC AGAGCAAAGC CCTAACTCTC TTCAATTCTC TG - #AAAGCTGA25380- GAGAGGTGAG GAAGCTGCAG AATAAAAGTT TGAGGCCAGC AGAGGTTGGT TC - #ATGAGGTT25440- TAAGGAAAGA AGCCATCTCC ATAACATAAA AGTGCAAAGT GAAACAGCAA GT - #GCTGGTAT25500- AGAAGCTGTA GCAAGTTATC CAGAAGATCT AGCTAAGATC ATCGATGAAG GT - #GCCTGCAC25560- TAACAGACTT TGAATGTAGA CCAAATGCTT TCTACCAGAA GAAGAAGCTG TC - #TAGTACTT25620- TCATAGCTAG AGAGAAGTCA ATGCCTGGCT TCAAAGCTTC AAAGGACAAG CT - #GACTCTCT25680- TGTTAGAAGC TGATGCAGCT GGTGACTTTA AGTTGAAGCC AGTGCTCAAT TA - #GCATTCTG25740- AAAATCCTAG GGCCCTTAAG AATTATGCTA TATCTACTCT GCCTTTGCTA CA - #TACATGTA25800- ACAACAAAGT CTTGATGATA CCTGTTTACA GCATGGTTTC CTGAATACTT TA - #AGCCCATT25860- GTTGAAACCT GCTTAGACAA AAGATTCCTT TCAAAATGTT ATTGCTCATT GA - #CAACACTT25920- AGTCACCAAG AGCCGTAATG GAGACATACA AGGAGACTAA CGTTGTTTTC AT - #GCCTGCTC25980- GCTTAACATC CATTCTGTAG CTCATGGATC AAGAAGTAAA TTAACCTTTT AA - #GTATTATT26040- ATTTAAGAAA TACAGTTTGT AATGCTTTAG CTTCTGTAGA TAGTGATTAT CA - #GAGATGGG26100- TTTTTAAGAG GTTTTCCAGA AAACCTTCTG GAAAATATTC ACTATTCTAG AA - #GTCATGAA26160- GAATATTTGT GATTCAGGAG AGTAGGTCAG AATATCAATA TTAATAGGAA TT - #TGGAAGAA26220- GTCGATTCTT ATTAAAATCA AGAGTTTAGT GATAGACATA CTGAGTTTGG GA - #TACCTGTG26280- GAGTAGTCCA GAAGTTAATT TAAATATATG GGCTTAGTGT ACAGAAGTGA GC - #AGGGTGCT26340- TATATATGAA TAAATATTAT TTTAAGATAT ATTTAAATTT TCCTTAAAAT AA - #TACCTATA26400- CTTGATATAA AAAGTTAATT GGAAATTAGT GGCTTATGAC AAGCATACCA GC - #CCACACTC26460- TTCCCAAACC CACTTTGCTC TTATTCATAG AAGCTGTCAT CTTCAAATCT TC - #CAGCTGAT26520- TTCCCTGGCG TGTGCCTTCT TATTTCTGAA TGACACGCTT AGAGTACTAT TT - #TTTTGACT26580- TAGCAATTTT AGAAATTTTC TACTCATCTC CTATTATGGT AGATTTCCCC TC - #CTTCATTC26640- CTCCTCCAAT ATAATTATAT TTCGTCATAT TAATAATTTG TTTATATATA TT - #TTTAATAT26700- AATATGATAA TATTGTATTT ATATTATTAA AACTACACAA ATATTATATA CA - #CACTACTA26760- ACCCAACCGT GTTATTATGG CCACCACTAC CTTTATTTTT TTCCTTGTGT TA - #GTGATTGT26820- CTTTGTTTTA TTTTCTTGGT TTTGAGTATT CCTTTTACTA ATTTTCTTTT TT - #CCTATTTC26880- AATCTCTCAT TATTTGTTTA CTCATTTGGA GTGTTCCTTG ACTTTTATCC CC - #TCTTACCT26940- AGTGACATTT TAATTTTAGT TATCAAATTT TTAATTTCTA AGAATGCTTC TT - #GTTCTCTT27000- CTTGTTTCTT CTTCCCCACC AGCCAAAAAT CTATGATGTT ATAGCAAGGA TC - #ATACATTG27060- TTTCCCAGTA GGTTAAGAAA CCTTGGTTAA AACCTGTTGT ATCCCAGTAA GT - #TAAAAGAC27120- GTTAACGTGT CATCTTCAGT ATGGATGAAA GAATATTTTC TTTCAAAAGC AG - #TTGGTTGA27180- GGAAGAGAAT GGGACAAATG CTCTTTTTAA AACACCAATT TTGTGATGAA CT - #CAAATTGC27240- AATTTTAACT TTACCATTAT AATGAATGTA TTTGATCCAA AATGTTTAAA AT - #CTAGGCTG27300- TTGTCATTTA AATAACAAAT TACCTTACTG GTATCATGAA GAATAAATGT TT - #GTACTGAT27360- TTGGAAAGAC ATTCTCATTT AGGGGATGAA ATAGAAAGTC AATGAGGAGA AA - #GAAAAGCT27420- TTTATTATTT ATTTTCTTTT AAATATTTTA GTATCATGGT ACAGTCACCA GA - #AAAAGCTT27480- ACAGTTCCTC ACAGCCTGTT ATTTCGGCAC AAGAGCAGGA GACTCAGGTA AG - #GCTTTTGT27540- AAAAAGGTAA TTAGTTTATG ATAGGATAGT TATGATTCTA TGTATGCTTA AA - #ATTCTGTA27600- TTTTGCCAGC ATTTTAAAAA TTGTTCTTAA GCTAAGAGTC TGAGTTTATA TT - #TCAGTTTA27660- TATTCATTCT AAGGAAAAAT GTGGTATCTG AAGCTCTAAA AATAAAGGAC TA - #GATCTTTT27720- AAGTACACTT TAAAAAGTGT TGTTTCTTTG TTTTTTGTTC AGATTGTGTT AT - #ATGGCAAA27780- TTGGTAGAAG CTAGGCAGAA ACATGCCAAT AAAATGGATG TTCCCCCAGC TA - #TTCTGGCA27840- ACAAACAAGA TACTGGTGGA TATGGCCAAA ATGAGGTAAA CTATCTTTTG CA - #TGTGTTCT27900- CATTTATTTC CTTCTAACAA AATAGATTTG GAAAATATAT CTAAGTTGAT AA - #TATGACCA27960- TAGCTTCCAC TGTCACATCT GGGAGGTGAC TCAGATTCCC CCTGCTGCGA TG - #CTTATCTC28020- TTTGCCAAGC TTTAGTACCG TGTTTCTGTA TGAATAAAAA CCAGTTACGT TT - #TCAGCAAT28080- CATATTCAAT ATTTATAAAA TCTAACTCAT TATTTACCCA CCCTGCATTT TA - #TCCAAATG28140- CCGAAACTCC TCTTTTTGGA TTCTTTATTT TTGATTATCT TACCATCACA TT - #TGTAGTCA28200- GAGGTTCCTA ATGCTTAAAA CCTCTGATCT GAATTTTCTC TCCTCCAATA TA - #AAACCCCT28260- TCGTCTTCCT CTTCTTCTTC TTCATTTTTT TTTTTTTTTT TGTCTGAAGA CT - #TGTCTCAC28320- TGTGTTGCCC AGGCTGGAGT GTAGTGGTGC GATCACTGCT CACTGCAGCC TT - #GACCCCCT28380- GGACTCAAGC TATCCTCGCA CCTCAGCCTC CCGAGTAGCT GGGACTACAG AA - #CATGCCAC28440- CATGCTCAGC TAATTTTTGT ATTTTTTGTA GAGACAGGGT TTTGCCATAT TG - #CCTAGGCT28500- GGTCTTGAAC TCCTAAGCTC AAGCAATCTT CCCGCCTCAG TCTCCAAAGT TC - #TGGCACTA28560- CAGGTGTGAG CCACTGTGCC TGGCCTCTTT TTCTCATTTA AATACTTTTC AT - #ACCTTTTG28620- TAAAACGGGT TCCTTGTTGC CTGTCTATGC CTTCCTCCTC CTTCTTAATG AC - #ACCACGTT28680- AATTCTGACT GTTTTCCCTT GGCCTGTTGC AGAAGCCTCT TAACTATTAA CC - #CTTCATTC28740- TCTCTCTCTG TTTCATCTGA TATATGAGTA CCAAACTAAA TCTTCCTTTA TC - #ATATCTTA28800- CTTCTGCTTA AATGTTTTTT TTCTAGCTTA GAATTCAAGG CCCTCTATTT AT - #GAACTTAA28860- ACTTACTTTT CCCTCTAAGT TACAGAATTT GAAATGGTTT ATCTTACCTG GA - #TTGTTTAT28920- CACTTGTTGA AGATCCATTT TCAACTTCCA TATATTTATT TACAGTGTTG CT - #TCTCCTTG28980- TAGTTTCCTT GATTCCTCAA AACTCCTTTT AAGAATTCTT GAAGATCTCG CT - #TTATTACT29040- ATTTCTCGCT TTATTACTGT AAAGACTATG AGAAGGTCTT TCATGATCTT AT - #CAGCAAAG29100- TAATTCCTCT CTCTTGAATT CATAGAGGAC TTTCAGATGA ATTCTAAAGA TG - #CTTCTGTA29160- GCACTTACCA CACAATNGCT ATATTTTATT TTTTTGTAAT TAGTGGTAAA CA - #AGTATTAT29220- TATATCTTNC TAGATTTTAA ACTCCAAATA AAGATACTAG CTCCTTACCT TT - #TTGTGTGT29280- CTCCTGTAGC ACCTAGCACA ATGCCTCATA AACAGGAGGT GATCATTAAA TA - #TTTAGAAG29340- AAATTATTTC CCAAGAATAG TTGCTTGGTA ATTGTATTTG TCTTTTACTT CC - #TTTTAAAA29400- AATTGTTTCT GTCACTAAAT TGCATCCAAT AGATGTTACT TGAGTGCAGA AT - #TTTCTAAT29460- GACATTACAC AGTGCTACAT CTGACACTAA TTCTTTTGTT AAAAAATAAA TA - #TTCTGGCC29520- GGGCGCTGTG GCTCACGCTT GTAAATCCCA GGACTTTGGG AGGCCGAGGC GG - #GCGGATCA29580- CGAGGTTAGG AGATCGAGGC CATCCTGGCT AACACGGTGA AACCCCGTTT CT - #ACTAAAAA29640- TACAAAAAAT TAGCCGGGCG TGGTGGCGGG TGCCTGTAGT CCCAGTTACT CT - #GGCGGCTG29700- AGGCAGGAGA ATGGCGTGAA CCCGGGAGGC GGAGCTTGCA GTGAGCGGAG AT - #CGCGCCAC29760- TGCACTCCAG CCTGGGTGAC AGAGCNNNAC TCCGTCTCAA AAAAAAATAA AA - #AATAAAAA29820- TAAATAAATA TTCTAAGACC ATACTTTAAT GGAGGTGTTT TTTGTTTTTT TT - #TGTTTTTT29880- TTTTTTTTTT TTGGTGATAG AGTTCTCACT CTGTCACCTA GGCTAGAGTG CA - #GTGGCGCG29940- ATNCTCNGGC TCACTGCAAC CTCCGCCTCC TGGGTTCAAG CCATTCTCCT GC - #CTCAGCCT30000- CCGGAATAGC TGGGACTACA GGTGCGCGCT GCCACCCCCG GCTAATTTTT TG - #TATTTTAG30060- TAGAGATGAG GTTTCACTGT GTTGTCCAGG CTGGTGTTGA ACTCCTGAGC TC - #AGGCAATC30120- CACCCGCCCC GGCCTCCCAA ATTGTTGGGA TTACAGGCGT GAGCCACAGT GC - #CTGGCCCA30180- GAGGAGATAT TTAATGAAAA ATAATAATCA TTAGATAGGC AGATTTTTAG AA - #GGAGGGCA30240- TCGAATGGGT TCTTGGATAT TGGACACAAT AAGAAATATT GAGCTAAAAG TC - #TGAAGGAA30300- TTGGCAGATA TACTGTTACA GGTAAACACT TTGTAGAAGA AAATAATGAA TG - #AGACTTTC30360- TTTTGAGATT TTCTTAGCCT CTTAGTTGTT CCCAGTTAAA GCCTCATATT TT - #TCCTTTTC30420- ATGACAATAA AAATAATAAT AAAATCAGTA ATAAAGTGAA TATATGAGAT GT - #TAACCTGT30480- TCCTTTATGA CAATGTCCTG TTTACCAATT AACAGTGTGT TTTTGTGGTG AT - #GGGGGCAA30540- GACAAATCTT TAAATGGTGG AAAGCAAAGA AAGAAATTAT AAAACATGAT TA - #GTTGTATT30600- ATACGTTGTT TTTGGTTGTT GGAAAAACTA TACATTTATT GAGAGAATCA TT - #AGGAAGCT30660- GAACATCAGC TATATTGCTG GAGTGATACT GTTTCAGTGG TTTCTTGACC TT - #TTTGTTGT30720- TGTTGTTGTT GTTGTTAAAC ACAGACCAAC TACGGTTGAA AACGTAAAAA GG - #ATTGATGG30780- TGTTTCTGAA GGCAAAGCTG CCATGTTGGC CCCTCTGTTG GAAGTCATCA AA - #CATTTCTG30840- CCAAACAAAT AGTGTTCAGG TAAAATACTG TGGTTTGCAG GAGCTCTTAG AG - #AATAAGCA30900- TTTTTTGTAA CCATTTCAAA AGTACCCTCC AGAAGCAACA TTTGCTCACT TT - #ATTTGCAT30960- TTCCATACTG GACACTTAGA AAATGAATTA AAATTGTTTT TACAGTCAAT CN - #NTGTTGTA31020- AAAACATGTC AGTTATCTAC TTTTAAAGAT GATACTAAAA AGTAGTTGTC CA - #GGCTGCTG31080- ATGTCTTTCT ATTTCATTGG GAGGTTTTGT TTTTAAATTG GAAACATTAT TT - #TAGGTTGA31140- TAAATTATAA TTTTACATTC AAATGTGGTA GTTGGAATTT AAAGCTGGAA AG - #TTATCCTT31200- GCTATGAGTT GGTCAGGAGC TCAGCCACTT TCTTTTGGTT TAGCATCTTC TC - #TAATCTCC31260- CTCCCCTTCC AGTAATGCTG TCTTTTGATA GTAAGTGGAT TTCATATTAT TC - #TCTTCAGT31320- TTTAATAGTG TTTCCTTCAT ATCCTTTTAT TATTGCTTGT TCTGCCCTAA GT - #GACCATTT31380- CCAGAAATGT CATTTAGGNA TTTTCTCTAA ACTCCACGTA GCAGACTCTA TA - #ATGCATAC31440- TCTGCAGAAG GTGAGGCAGT GGGAGGTAGA GGGGAGACTA CTAGACTAGG AG - #TCACGGAA31500- TCAGGACTTT AGTTCTTCCT TACAGTTGTT CACCTGGTGA ACCTGCACAT GT - #CCTTTAAT31560- TTCCTTGGGT CTCCATTTCC TCAGCTATAC AATGGAAATG ACACTTCCTC CC - #CCACATCC31620- AGGAAACAAC AGATGACATT AGAAAATAGA AGACATGGGA TAAGTATAAA AT - #GTTGAAAG31680- AGTTAAACAC ATTCAAGGCA ATATTAAGGG ATTATTTTTT ACTTCCAAGA AG - #CTCCTGGA31740- AGCTTTGGGC AGGCACAGTT GGATCCTACT TTAGAAAAAT CTTTCTCTAA CT - #ATAAGTAG31800- AAAACCCTTC TGCTTTTTGA ATGTAGCATT TCCCTCTTTT GATATAGAGT AT - #CTTTGGCA31860- ACTTTGAATT TTCTTTTTCA TACTCTTATA TAAGACATCA TGTGAAAATT CT - #TATTTCTT31920- ACTGAGTTTT TGGAAATGAA ATTATAATGT CTTAATAGTT TGAGAAAGAA TA - #TCATACCT31980- ACCAGCGGTA ATTGAGTAAG TTCCCTCTCT TTGGACACTT GAAAGTAGTA TC - #TTCTTTCA32040- TGAATTAGTG ATATTATTTA ATAATGAATG AGTGATCTCT CCTAACTCCC CT - #TCAGAAGA32100- GGAAAATGAA GTAGGGGAAA AGGTAAATTC CCCAAGGGAT AGGTATGAAA CC - #TTTATGAA32160- CCTTCTGGAT AGAGAAGATG ACTGCTGATT TCTGTGATTA GAAATTATAC TT - #GGGTTATT32220- CTGCAAATTG AAATGAATTA TTTAAAAAAA AACAACTTTA ATGTTTATTA AG - #CAAGTTTT32280- GTTATTCATG AGTTTCATTA GCCTTTTATT TTTTTTTTAA ATTTTGAAGT AA - #AATTTCTT32340- GCTGTCACAA TACACATTAA AAATTACAAA TATGACACAT ATTAAACACA TT - #AAGATGGC32400- CGAATAGGAA AAATATGCTA AAATATTTTT ATATAAATAC ATTTTTTGAG AA - #TTTTGAGA32460- ATTTCTGGAA CAAAGTAATG ATATAATCCA TAAATGTACA ATTAAAGAGT TT - #AAGGATAT32520- CCAAAATACT TGGCAAAGTA ATCTGAAATA ATACTCTTAG GAAGGTAGGG CA - #AGAATGTG32580- ATTCTAGTAA GCAAAAATGT AATCAAATCG TATTCTAGTC CCAGCTACTC GG - #GAGGCTGA32640- GGCAGGAGAA TGGCGTGAAC CTGGGAGGCG GAGCTTGGAG TAAGCCGAGA TC - #GTGCCACT32700- GCACTCCAGC CTGGGCGACA GAGCGAGACT CCATCTCAAA AAAAAAAAAA GA - #CTATATGA32760- ACTTGTATGG CATAAATATG TACAAATATT ATTTATTTTA AAAAAATTCA GG - #GGTAGGGA32820- CAGGGTAGTT AGAAAATATC TAAGGATGTT CATGAAATAA TACTGGCTAT GA - #ATGACAGT32880- TGATGAAACC GGGTGGTGCC CNATCTTATT CCCTCGACTC GTGTATATGT TT - #GATATATC32940- CCACAATAAA CCTTAAAAAA AAAAAGNATG AGTGGTCAAT TATAGGAAGA TA - #TAAATAGA33000- AAAGGCAATA AGGACAAAAG TTGGCAAAGC TTACCTAAGC ACTCTTCAGA TA - #AAAAGACA33060- TTTTTGCTAA CTAGATTTGA ATATTATAGT TTAATTGTCA AGGAAAATGC CT - #CAACTTAA33120- TCTTTGTTAA GAGACTACTT AAGGCACTAT CAGAAGTTCC CTCATGGCAA GG - #TGCAATCC33180- CTCATGCCTG TAATCCCAGC ACTTTGGGAG GCCAAGGCAG GCAGGTTACC TG - #AGGCCAGG33240- AGTTAGAAAA CAACCTGGGA AACATAGTGA GACCCGACCT CTACAAAAAC AA - #TTTCTTAA33300- AATTAGCCAG GCATGGTGGT GCTAGCCTGT AATCCCAGCT ATTTAGGATG CT - #TAGGCAGG33360- AGGATTGCTT GAGCCCGGGG ATTTGAGGCT GCAGTGAGCC ATCATTGTGC CA - #CAATACTC33420- CAGCCTGAGT GATAGAAAAA AAAAAAAAAA GTGTCTTTGT TATATTCCAA AC - #TTGTTCTC33480- AACTTTCAGG TGAGCTGGCT TCCTGTATAA CTCTTGTATA GGACAGAACA TA - #CTGGTTGG33540- GGCAAGTGAA ACTGTCTAGT TGTATGCCTC ATAAATTAAT GAATTTCCTT TC - #TAATATAT33600- ACACTGATAT TTATACACAC ATACACATAA AACCAAGCTC AATAGATGGG TA - #GTGCAGCT33660- CTATTCCCCA AAACCCAACT ACCCTGTAAC AAGACACATT AGACTTTTGA GA - #TTGCAAGG33720- ATGAGGACTG AAATGCTGGC CTAGACCATG GTGTTGCCAT AGTGGGGTGA CC - #AGTCTGAA33780- TAGCCAACAA TGCTTCCTCA GTAAATACCC ATTTTGTCTT GGTGGGATTT CT - #ACAAATTG33840- CAAAATGCAG CTATTATGAA GCTGTAAAAG AGNAAACANG AAACATGTAA CA - #CCTGGGAC33900- TGTTTTATTA GGCCCACCGT ATGCTCAGAA CATGAAATCT CCACTGCTAG GG - #TTATTTGA33960- TTGAAATTAT CTTTTGTGTT GATGTGAGAG TTTAGCTCTG AGATTCTTCC AC - #ATGTAAAA34020- TGTAATCCCC CAAAGTATTT GGCAAGCACA TTTTATTGCC TTGGGTCAGA TA - #ATTGAAAC34080- ATTAGGCATC ATATATATAG CATGTAAAAA GTAAAACAGA AACATTTATG TT - #TCTCACCA34140- AGCAGTAAAT TAGTACTCAA CTAATAAATT TCTTAAACTC CCTAATAACA GA - #ATATGGAA34200- ACAAAAAATA AATCTTTCCA AAAGAAGAGC TCATGGACAC ATTTCCTCAT AT - #ATGTATAC34260- ATAATATAGT AGAACACATG ATAAATAACC TATAAAAATG ATACCAATAT CA - #TTCATCAA34320- GAGACGAGGC TCTTCTTTAA ATTATTAATT TCATCTGTTA CAGGTTTTAT TA - #TGACTGTA34380- GTATGCTGTT TTCATCTACC TTTTATGTGT AGTTAAAAAA ATAGTTTTCT AT - #CTCTTTAC34440- CTTTATTTCA GCCTTTAAAA AGATTCCATT ATTTTTTCAT TAATCTTGTT TT - #TCAGTTTT34500- TCCCATTTTT TCTTTTAAAC ATTTCTTAAG GAACCATATT TAAGATTTTA TA - #GAATACTT34560- AGATTTCTAG TTGGGATGTA TCATTTAAAA TTAGATATGT AGAGAGAGTG TT - #ATGATATA34620- TTTCCTTACG ATATATTAGT GGTTATAGTA CCTAAATTTG AATAGTGATT CT - #GTTCATTC34680- ATTCATTCAT TCATTCAATA TTCACTTCCA GGAGATTGGG GACTTATTTA AA - #GACAGAGT34740- AGTTCACATT ATAGTTCCTT TTTTTAGTCC TTCTTATTCG TTAAAGAAAA GA - #CTAGGAAA34800- TGTTTGTTAT TACAAATATT TTATTAAAAT TTTGTGTGCT CTAGCATTAT TT - #TACCTTTT34860- AAAATCAATA TGTTAAAAAT CCAACTTCTT TTTGAGCTCC CCATAAAAAG GG - #AATTATTT34920- GTTGCTTATG GGTTTAACTT GTGTTATTTT TTTCTTAATG GCTAATTATC AT - #ACATATAT34980- TCTATTATTG TATTGATATT ACTGATCATT TGTGCTACAT TAAAAATTCT GT - #AGACAGAC35040- CTCTTTTCAA GTACAAAACC TCAAGAAGAA CAGAAGACGA GTCTGGTAGC AA - #AAAATAAA35100- ATATGCACAC TTTCACAGTC TATGGCCATC ACATACTCTT TATTCCAAGA AA - #AGAAGATG35160- CCTTTGGTAA GTGTGACTTT CATGTTACAG GGAATTTTTT TAGTTTACTT AA - #ACTTGTGT35220- TTTATCAGCT TTTTAGTATT AAAGTTCTGA CTTGGGATCA ATTTCCTCCA AC - #CCTACAAT35280- AAATCTCAGT TTATCTTTAA TTTTAAAAGA GAATGTTGTT TTCTTTTTCT GT - #TAAGCCTC35340- CCTGTTAAGT AATAGCAGCA AGTTTAGTTT GGCCATGAAT ATCTTCTAGA GA - #TTGTATCG35400- GGGTACTGAT AAACACATTT ATAGCTCAGG GATACTGCAT CAGCCATATT TT - #AAAATGGG35460- ACTAACAGTT TAAAAACTAT AAATATTCAC AGTGTTAAGA AACAATCTCA AG - #ATGCATTA35520- AGAAAAAGGA AGGTGCAAAA CAGAAAAACA AACGTAAACG TGTGTGCATA TG - #CATGCTTA35580- TATAGTCACA TATTCTTGTA TGTGTACAAA AAATACACAC TGGATCTCTG CA - #AGCATAGC35640- CAAGCAACTG GAAATATGTT TTTAAAAACT TGCTTTTCAT TCTATCTCTT CT - #AGTACTGT35700- TTTGATGCTC TTTGAAAACA ATCTAATTGC TGTAACAAAT GACCATACGT AG - #GCCGGGTG35760- TGGTGGCTCA TGCCTGTAAT CCCAGCACTT CGGGAGGCTG AGGCAGGCAG AT - #CATTTGAG35820- GCCAGGGATT TGAGACCAGT TGGACAACAT AGGGAGACCC TGTCTTTACT AA - #AAATACAA35880- AAATTAGCTG GGCGTAGTGA CGCATGCCTG TAATCCCAGA TACTTGGGAG GC - #GGAGACAT35940- GGGACTTGCA TGAACCCAGG AGGCAGAGGT TGCAGTGAGC TGAGATTGCG AC - #ACTGCATT36000- CCAACCTGGG CGACCGAGCA AGACGCGGTC TCCAAAAAAA AAAAAAAAAA AG - #ACCATATG36060- TAATGTTTCT TCATTGTTCT AAGATAAATC TTTAAGGCTG TTGAGGTTTT TT - #GTATACAA36120- AATGGAGAGT AAGTTTTAAT GGGATGGGAC AAAATGAGGC TTACAGTTGA GT - #TTAATTTG36180- AGTTCACATC CTGTTGACAT TAAGTTGATT TGGAACAAGT GATATGGTCC AA - #TGCCTGCT36240- TTTCTATTGT CTGTGGTTCC ATCCACTAGT GCCTGTGTTA CACACCTCTT GT - #TCAGGTTT36300- TATCATTTAA AATAAATAAG AATAAACAGT CCATAGCTTA TCTTACTTAC TG - #AATAAATG36360- CTCTGATTTG ACAGTCATGT TTCTTAAAGT TCCTTACAAA GGCCATTGCC CA - #AGAAACCA36420- AATAATTCCA TTATACTATT TTTGAAATAG AACACATAAT AAATGGGAAT TT - #TAAGTTCA36480- GTTTCTTATG TAAACAATAA CTTCTATGTA CATGTTAAAT ATGCCTGTAT AT - #ACCTAATT36540- TGACCATGTA TGTATAGTAG AAATGAAAAC AGTTACTAAG AAAATTTGTT AT - #TGGCTCCA36600- AATTTTCTGA ATTAAGTGTA TTNCTAATGC TCAGCCATAA TATGGGGTTT CA - #TGTGTTAG36660- TTTATGTATT CATGGTTAAA AATGTGAAGA CTGTTATATC TTCATTTGTG TC - #TTTTGGTA36720- TTATTTGGTT GTATTTTATT GTGTGATATG GTGGTATAAT TATCCTTACC TC - #CCAGGAGT36780- TTGAGAGGGT CTTGCCAGTT AACCGCAGAA TTAAACATGC CTAGGACTAA TT - #AATCAGGA36840- GCAATACTAC AATTAATTGG AGGTAATTTG AAACCTGGTT TCAAATAACC CT - #GATATTAT36900- GCACACATGG TGCACACTTT TCTAGTAGAC ATTTAATGAA AGTAATTTAA AA - #CCTACCTT36960- TGAAGGATGA AAAACATTGC CTTAAATGCT CTATTCTGTG AAAGTATCAA CA - #TTTATGCA37020- AATACAGTCT AAATTCAGAC TTTGAAAATG TATTGAAAGA GAGGATCATG AA - #ATAAGTTA37080- GAGCTGAGTG ACAAAGCTTT CTGAGTGTTT AAAAGAATGT TTTACCTAAT AA - #ATATCTGA37140- AATGTATTTG GAGCCACATT TGTTTAAAGA ACTGTATAAA TATGTAGCAC TG - #TTCATGTG37200- AAGTTCAATA GTAGGAAAAT GCTGACAGCC CTTGTGGAAC TGTGGTTATT AT - #TATTTTAT37260- GAATAGAGCC AATTTCAAAC ACCTATTAGA GTCTTCTCAG GAACATTTTA TA - #GAATGCAT37320- CTGGAGCCTT ATGTTATCTC TAAGCATTTT AGGATTTGTC TTCTTGGAAA TT - #CATGTAAC37380- CAAACCACCA TGTGTTATTT CAAGTGTATA TAGTATTGGG TTACAGTTTA CT - #ATGTTTTC37440- AGAAGGTTGT GACAACTATT AGACTTACAG AGAATGACTT CTCTGCCACT AA - #CGGCTTTC37500- TAAAGTGAAT AGAGAGGGGC GAGGATTGAA TTCTTCGGTA AAGCTGGGTG AT - #TTTGTTTT37560- ATTCAATACA GTATAATAAG TATAAAAAGT AGAACCTATA GAGAGCTATA AT - #GGGGGTAG37620- TTTTAAAGAA ATTCTGAAAA TGAAAAACTT AAGTAAAGGT TTAGTTCATT GT - #TTATTTCA37680- CACTGAGCAT TTACTACCTG AATGTTTTGG ACATTTTATT TCCATGACTG GA - #GTGGACAC37740- TTTTACAACT CACTGGGTTC TTTGCTGATC TTTCTCTAGA AGAGCATAGC TG - #AGAGCAGG37800- ATTCTGCCTC TCATGACAAT TGGCATGCAC TTATCCCAAG CGGTGAAAGC TG - #GCTGCCCC37860- CTTGATTTGG AGCGAGCAGG CCTGACTCCA GAGGTTCAGA AGATTATTGC TG - #ATGTTATC37920- CGAAACCCTC CCGTCAACTC AGGTGAGAGG CATGGCCTAG CTCTGCACCC TT - #AATGACTT37980- GATGAAGTAA ACAAGCAATC CACTATATTT TTCACTGTTA ACAGCATTAA TC - #CTTTATGC38040- TATTATGAAA ACCTTACTTT TGTGATTCTT TTTCTTGTTT TAGGAAAACA AT - #CTTTCTTC38100- CCATTATCAC TCAGAGGAAA GTATACTGAG AAATTTTTTT GTTTTGTTTT GT - #TTTTTGAG38160- ACAGAGTCTT GCTCTCTTGT CTAGGCTGGA GTGCAGTGGC GTGATCTTGG CT - #CGCTGCAA38220- CCTCTATCTC CCAGGTTCAA GTGATTCTCT TGCCTCAGCT TCCTGAGTAG CT - #GGGACTAC38280- AGGCGTGTGC CACCATGCCC AGCTACTTTT TGTATTTTTT GATAGAGACA GG - #GTTTTCCA38340- TGTTGGCTAG GCAGGTCTCG AACTCCTGAC CTCTGATGAT CCGCCCACCT CA - #GCCTCCCA38400- AAGTGCTGCG ATTACAGGTG TGAGCCATGG CACCTGGCCA ATACACTGAG AA - #ATTTTTAT38460- TTTCCTTTTC AGCTTAAGGT TACAACTTCC CCACCATCCA AAACGTGCAC TT - #TCATTTTT38520- TTTCTAATTT CTATCTCATC ACTTGCAAAA ACCATATTTT TCTCCACATT CA - #TTCCCAGT38580- AGCTTCCTGA CTCCTAGTTC TTCCCTAAAT CCTTCTGAGT CCTTGTCATT GG - #TTTCGCTT38640- GAGTAGCCTT TCTAATCAAC ACAGTCATTG GTATCAGTTA CTGTGACATG GA - #AGGGACAG38700- ACCAAGTTCT GTGGGCCGCT ACGTAGAAGG ATTTCCTGTC ACTTTGCTGC AG - #AACCTCAG38760- CTCGCGGAGA GCAAGCCCCT TTGCTTGCCC TGTAGAAATA TTTTAAATTA TT - #ATCCTTTT38820- TTTTTTNAAC AGAAGTAAAT AGGAGATACG TTAGAGGATT TTCTCTCCTA GA - #TGTGTAAA38880- TACAAACTTG GGGTCTTATA ACTCAATAAA TCTGATAAAT TTCTTTTGAC TG - #TTAGGATA38940- GAGCAGTGGC CATACCAATA GCCTCATCTC CAAAGCTGCA GTGAAGATAC TT - #TTTACTAC39000- CTTAAAGTCT TTCCCATTTG TGAACAACTT GTGAACAATT CCCCCCAAGA AT - #TTGGAAGA39060- TCACTCTCTG AAAGCACAGT CAATACTGTA CTTAAATGGA TCTGAGCAAA AA - #TAAGTCAC39120- TTAGAAGACA GGATTATTTC TAGACTTGAG TGTGACTTGA CTGAAGGTCT AA - #AGAACAAA39180- CAGCTCCTTC ACTTCCATTG ATCACGGTGG AAGCACAGGG AAAGGACAGA CA - #CGGAGGCA39240- AGTTGGAGTA GTGCTCATCT AAGTTCCAGG GATGCGGGGG AGTGGCCAGG GG - #ACTTCAGG39300- TATAGTAAAT AAATAACCTA TTTATAAGTT ATGTCAATGT CATGTTTGAA AT - #AGAAAACC39360- AAATACTGCA TGTTCTTACT TACAAGCAGG AGCTAAAGTT GGTGCATATG GA - #TATAAAAA39420- TGAGAACAGG CCGGGCGTGG TGGCTTGTGT CTGTAATCCC AGCACTTTGG GA - #GACCTAGA39480- TGGAAGGATT GCTTGAGCTC AGGAGTTCAA GACCAGCCTG AGCAACATAG TG - #TGACCCCC39540- ATCTCTACAA AAAATAAGAA AATTAGCCAG ACGTGGTGGC ATATACCTAT AG - #TCTCAGCT39600- ACTTGGGAGT CTGAGTCAGG AGGAGTGCTT GAGCTCAGGA GTTTGGGGTT AT - #AATAAGCT39660- GTGATCATGC CACTGTGCTC CAGCCTGAGT GACACCCAGA GTGAGAACCT GT - #CTCAAAAG39720- GAGAAAAAAA AAAAAGTAAC AGTAGACGCT GGGAACTACT GAGGGGAGGG AA - #GGAACAAT39780- GGTTGAAAAG GTGGGAAGGG ACAGTGGTTG AAAAACTACG TGTTGGGTAC TA - #TGCTCACT39840- ATCTGGGTGA TGGGATCAAT TGTACCTCAA ACCTCAGCAT CCTGCAATAT AC - #TAATGTTA39900- CAAACCTGCC CATGTACTAC CTGAATCTAA AGTAAAAGTT ATAATTTAAA AA - #AATTATAA39960- TAAAATCAGA AAATAAAGGT CTGAGATGGA AAATTAAAAG ACCAAAGCCA CC - #CATAAGCA40020- CAATAAATCC CTCCCCCCAA AAAATTATAT CTATTAAAAA AAGGTGTTGC GC - #CAGGCACT40080- GTGGCTCATG CCTATTGCCT ATAATCCTAG CACTTTGGGA GGCCAAGACG GG - #CAGATGAC40140- TTGACTTGAG GTCAGGAGTT CAAGACCAGC CTGGCCAACA TGGTGAAACC CT - #GTCTCTAC40200- TGAAAATACA AAAATTAGCC AGCAGTGGTG GCATGCGCCT GTAATCCCAG CT - #ACTCAGGA40260- GACTGAGGCA GGAGAATCGC TTGAACTGGG GAGGCGGAGG TTGCAGTGAG CC - #GAGATCAT40320- GCCACTGCAC TTCAGCCTGG GTGACAGAGT GAGACTCTGT CTCAAAAAAA AA - #AAAAAAAA40380- AAGACCTTGT ACCCTGACAA GTTTTAGTTT GTGCAGGAAT GACACAATCT AG - #AATGACTC40440- AAGATTGGAA AAATCTTTAA ATGTTAATTA CACAATAAGG GTAAAAGGAG AA - #AAATTACC40500- TAATGTCATC TGAGCAACAA GAAGAAGAAA TGAAAGGCAT TAAAAATTGG GA - #AAAATTTA40560- TATTTGACAG TATCTTAACA ACGAATTCTG CTTCTATATC ACTTCCTAGC TT - #TCTGATGA40620- TAACTTCCCG TGCAGATCTG TATGTAAGGA ATGGACGTAG TAGTCATGCT AA - #TCTGAGTA40680- TTTATCTGTG TGATACTTAC GAATTAACGA TGTAAGTTAA TAAGTTAGCA TT - #TCGTGAAC40740- CTGGTTAATA CCATTTGCTA AGGTTAAATT AGCCAAATCC TGAAGTAAGC TG - #TAAAACAT40800- CCAAGGTAGG GTAGAGAGGC ATCTTATGAG AAAGCTGGCC AACTCTCCTG GT - #CACCTTCT40860- AATCTTCCTA ACTTCAGAAA TCAAGGCAGA GAGAGGAAAA TAGTAATTAC TT - #TGTAGGAT40920- TAGATTTATG GTTGTCGAAA CCTTTGTTTC TCCAGTGCAG AATGAGATAG CG - #TTTTAGGG40980- AAAGCCAAAG ACTCAGATGT CTTCTTCATG CTCATCGTGT GGAATTTTTC TT - #CCTTTAGA41040- AATGTATTGT CTCTCAGGGC TTAAAGCAAT TTGCATCTTT CGATGAGACA TT - #GAGTAATA41100- GGCAATATTC TCTGAAATAA TTTGTGCAGG CTGGGCACAG TGGCTCACAC CT - #GTAATCCC41160- AGCACTTTGG GAGGCCGAGG CGGGCAGGTC ACTGAGGTCA GGTGTTGGAG AC - #GAGCCTGA41220- CCAACATGGT GAAACCCCGT CTCTACTAAA AATACCAAAA TTAGCTGGGC TT - #GGTGGCAC41280- ACACCTGTAA TCCCAGCTAC TTGGGAGGCT GAGGCAGGAG AATTGCTTGA AC - #CCCCATGG41340- AAGGTGGAGG TTGTGGTGAG CCAAGATTGT GTCATTGTAC TACAGTCTGG AC - #AACAGAGT41400- GAGACTCTGT CTCAAAAAAA AAAAAATAGA ATTTGTGCAG TTCCCCCCAC CC - #CCTTTTTT41460- TTTTCTGTTG GCATTTTTGC TATCATTTAG CTGCCTTCTT TATATCCTGA AA - #CTTACAGG41520- TGGTGTTGGT CTAGTCAGTA AGAGCAAAGG CTTTGGGAAT AGATAGATCT GT - #ATTTAGAC41580- CTTGGCTCTA GCATCTCATT GTTATGTGAC CTCCATCAAG TGACCTAATT TC - #CCTAATAT41640- TCAATTTCCT CATCTCTAAG ACAGGGAGTT AATATTGCCT CTCTTATAGA AT - #TGTGAGAA41700- ATATAGTCAT GTGTCGCTTG ATGATGGGGA TGAATTCTGA GAAATGTGTT GT - #TGGGCGAT41760- TTCATTTTGT GGGAACCTCA CAGGGTGGAC TTAAACAAAC CTAGATGGTA TG - #GCCTACTA41820- CACACCTAGG CTGTACGGTA TAGCTCCTGT CTTCAAACCT GTACAGCATG TG - #ACTTTACT41880- GAACACTGTA GGCAATTATA ACACAGTGGT ATTTGTATAT ATAAACATAG TG - #AAACATAG41940- AAAAGGCCCA GTAGAAATAC AGTGTAAAAG NATTTTTTAA AAAAGCTGGG CA - #TGGTGGCT42000- CACGCCTGTA ATCCCAGCAC TTTGGGAGGC CGAGGCAGGC AGATCACTTG AG - #GTCAGGAG42060- TTCAAGACCA GCCTGGCCAA CATGATGAAA CTCCGTTTCT ACTAAAAGTA CA - #AAAATTAG42120- CTGGGCGTGG TGTTGGGTGC CTGTAATCCC AGCTATTCAG GAGGCTGAGG CA - #GGAGAATT42180- GCTTGAACCC AGGAGGTGGA GGTTGCAGTG AGTCAAGATT GTGCCACTGC AC - #TTCAGCCT42240- GGGAGACAGA GCGAGACTCT GTCTCNAAAA AAAAAAAAAA AAAAAAGAGA TA - #AAAAGGTA42300- CATCTGTACA GGGCACTTAC CACGAATGGA GCTTGCACCC TGGGAGTTGC TC - #TGGGTAAG42360- TCAGTGAGTG AGCGGTGAGT GAATGTGAAG ACCTAGGACT GTGCACTGCT GT - #AGACTTTA42420- TAAACCCTGT GCACTTAGGC CACACTCACC CCTGTGATAC GAGTCTACCT AC - #TGTATAAC42480- GTACCTGCAT ATGTACCCTT GAAACTAAAA CAAAAGTTAA AAAATTTATC TT - #CTTTTGCC42540- AATAATAAAT TAACCTTAGC TTACTGTAAT GATTTTTCTT TATGAATTAA AA - #TCTTTTTA42600- CTCTTTTGTA ATAACACTTG GCTTAAAACA CAAACATATT GTACAGCTAT AC - #AAATATAT42660- TTTCTTTATA TCCTTCTTCT CTAAGATTTT TTCTGTTTTT GATTTTGTTA AA - #TTTGTTTT42720- TACTTTTTAC ATTTTTTTTG TTAAAAACCA AGACAAAAAC CCACACATCA GC - #CTAGGCCT42780- ACATGGGCTC AGGATCATCA GTCTCACTAT CTTCCACCTC CACATCTTGT CC - #CACCAGGT42840- CTTCAGGGGC AGTCATATGC ATGGGGCTGT CATCTCCTGT GATAACAATG CC - #TTCTTCTG42900- GACACCTCCA GAAGGGCCTG CGTGTTTTAC AGTGAACTTC TAAAAAATAA TA - #AAATGTAT42960- AGTATAGCAA ACACATAAAC ATAGTAACAT AGTCATTTAT TATCATTTTC AA - #GTATTATA43020- TACTGTACAT AATTGTACAT GCTAGACTTT TACACAGCTG GCAGCAAGGT GA - #GTTTGTTT43080- ACACCATTAC CACCACAAAC ACATGGGTGA TGCTTTGCAT TGTGATGTTA CG - #ATGGCATG43140- ATGTCACTAG GTGGTAGGAA CTTTTCAGCT CCATGATAAT CTAATGGATA CT - #TGTTCCTG43200- TTGGCTGCCC GTCGTTGACT GCAACATCAT TATGTGGTGC ATGACTGTAA AT - #TAGATACT43260- GTTCAGAAAG CTTTGGCACA CTGGTAATAG CAAATGGTGG TGGCAAATAT GA - #TGATGATG43320- ATGATGATGA TTGAAGACAT AGATGGTAAA ATTTTATGGT GTCTTAAAAG TA - #CCCTCTAA43380- ATATGATTAT TTTTATAGTC TGTCCTTTTG AATAGGCACT TAAGAATGTA TG - #AACTTAAT43440- AAGTATATAA GAAAGAATGT TCCCCAAAAT ATATCTTACA GAGGCATACA AT - #TTAAGAAT43500- TCAAACAGGT TGTAATGGGG TGTGTGTGTG TGTGCACACG CGCACGCATG CG - #TGCTCATT43560- CACACTAAAG AATTCTTGGG CATATGTTCC TGAATGTCCT AAATGGACAT TC - #TAACATCA43620- CTTCATTATG GGCAGAGGGA AATGGTAAAG AAAAATTTCA TATTATATTA TT - #CAGCCACA43680- TATTGACAGC ATCTGTTTTA TTTGCCTATG GTAAAGAATT GAAGCACTGT TA - #ATTTGCTT43740- TTTAAATCAT GTAGGCACAA AGTTATCGAA CTTTAGATTT AGAAATGAAA CT - #GGAAATCA43800- TTACACTTTC CCTTTCCTAT CCCCACCCTG TTTTGGAGAG AAAGAGTGTG AG - #GCTTAGAG43860- AGTTATAAAA CTGTTTTAAT ACCATGTCTA AGATTAATAA CTGAACAAGT TT - #CTCTTTTT43920- ACTCGTGTTA AAGTTGTACT GCCAATTAAC TTAAAAGAAA GAAATATGCA AT - #TTCTAATC43980- CTGATATAGG ATATGGGTAT ATAAACTCTA ACTTGATGAG TGAAACAAAT TA - #ACTTATTT44040- ATAATCAGTT TCATATCTTT ATTTATTGAG TGTCTTTAAA TACCCCTTAC CT - #TTAAAGTA44100- AGAAATATTA AAATCAAGCA GAATATAATA ATGAAAAATT CTTAAGATAT AC - #TTACTAAA44160- AACTTATCGT TCGGTTAATA CACTGTATGT AGGTTGTACA TACAATATGA AA - #AAGTATAT44220- TTTTGTAGCC TACTTTTAAA TCCAGAATAG AGGAGGTTAA GAAGGTTGTG AT - #AACCATGA44280- GCTCTTTTTT TTTTTTTTTT GAGACAAGGT CTTACTCTGT TTCCCAGGCT GG - #AGTGCCGT44340- GGCACAATCA TAGCTTACTG CAGCCTTGAA CTCTTGGGCT CAAGCAAGCC TT - #CCACTTCA44400- GCCTTCCAAG TAGCTGGGAC CACACCTGGC TAATTTTTAA GTATTTTTGT AG - #AGATGAGT44460- TCTCACTACA TTGCCCAGGC TAGTCTTGAA CCCCTAGCCT TAAGCGATCC TC - #CCACCTCA44520- GCCTGCCTAA GTGCTGGGAT TACAGGTGTG AGCCACTGAG CCCAGCCCTC TT - #TTATTTCT44580- TTTGATAGTA CACTCATAAT CATTAAACTA TCATTTCTGG ATGTGAGATT GT - #GCTTTTGG44640- ATTCTTATTT TTTCTTTATA AAATACTTTT TGTTCTCTTA CTGGAGAAAA CA - #TTGTTGGA44700- TTATAAATGA TATAACAAGG AATGAGGATA TACATACTAT AATAACGATT CA - #GATATGTT44760- ATTTTCATAT TTTATTTAAC TGTAGCCATG CCACAATAAT TTAGAGTTTT AA - #AGAACAAG44820- TTTGATTGAA ATCTAAACTT TGTACAATCC TGAATTGAGA AGTTTCCTGT AT - #TTTATTAT44880- GACACAATAT TTACCTAAAA ATAGGGTAAT TATGAATTGA GAAAACATAG CT - #ATTAATTT44940- CATACTCTTA TTTGTTAAGT AGATTTTGTC TGGAAAACTG TTCATATTTA AA - #GGAGCTTT45000- GTACCTTTGT ATTCTTTTTG TTTTTCCTTG TTTATATAAT TTTAAACTCT GT - #TTATGGAT45060- TTGGGATTCT AACTATGCTA AATAATAAAT TAAGGCATTG AATGAAGTAC CT - #AGACAGTA45120- TTTTGATTAA TTTTATTCCC CCATTCTTAA TGTGCATGTA ACTGGAAAAT TA - #AGAGTGGC45180- TTCCAAGGGA TCTACTACAA AAGTAAGGTT AATATGATCT CTTTTAAAAC AC - #TGAAGGCG45240- TGTAGCCAGT GTTGTCATTA ATTCTGCAGT AGATATTTTC AGCACTTATT TA - #CATGGGAA45300- GTTAGAGCAG AGTAAGATGC ACCTGTAAAG CTAAATGCCA CTTATTTGCA TA - #TATATAAA45360- ACGCAGGATG AATTTACCAT AGAAATATAA AGGGTACTTA TAGAAATGTA TT - #AGAAAAAT45420- ATATGAATTT TTAACTTATA TCTAGAAGTT AACTTTATAC ATTTAACTTT AA - #ATCATTAA45480- TAGTGGTTTA ACACCATAAG CGGATGTTTA TGCATCATCA TTTTATGAAC AA - #AAGACATT45540- CTAATTTTAG AAATAAAGTG ATTCAAAAGA GAATAAAATA TCTTACTTTT TC - #TTTTAAAA45600- TTAATTTGTT TAGCGCATTA CATGATAATA GCTCAAGCTT GTGTGATTTT TC - #CCTAAAAA45660- ATTGGTTTAT AAATATTACA TTTATAGTAT GAAGAAATTA ATCATACATA GT - #TTATTTAT45720- CTAATTTCTA AATACCCATG GAAGAAAATG AATTTAATGG AATGTAGTTG TG - #TATTACTT45780- GGTTTCGAGT GTGGGAAAAT TTATATGGTC TTTCTAAAAC AGCACTGTCA GT - #AGAAATAC45840- AATGTGAGCT ACATATGCAA TTTTAAATTT TCTAGTAGCC ACATTTTAAA AA - #GTAAATGG45900- ATGCAATTTA TTTTGATAAT ATAATTTAAT TAGTCTACTA TATTTAAAAT TT - #TATCATTT45960- CAACATGTAA TCAATATGAA AATTATTAAT GAGATATTTT ACATACTTTT TT - #CTGTAATA46020- AGCCTTTGTA ATCAGGTATG TACTTTATAT ATACAACAAA TCTTCTGATG CT - #AAATTTTA46080- ACTGGAAATA CTTGATCTGT GTTTAGCTTT TGTAAAATTT ACTGTTGAAC AA - #CGTGGACT46140- AATGTGCCTA AGTGGTTCCA AACATATTTT AAAATTTGAA GACAAATAAA AG - #GGAACTCA46200- AAGTAAATTG GGATACATAC ATACAACAGA ATACTGAGCC ATTAAAAAAT GA - #TGAAATAG46260- TAAAATTGGG GGAATTTTGA TGATACTAGG ATGATATAAT GACCAAGAGA CA - #AATACAAT46320- TTTAGTTTGG TTGAGAGATG TGATCATCAC GTTGCTGATT TTACTATGTA TA - #GAGGTTAT46380- CTTTTCCTTT CTAAGATTTT GAAACTTTAA TTAGTTAACC CACTTACCTA GT - #TTCTATTA46440- GCTGTGTAAC TTTCTCTTCC TGTTTTTTGT TTTGTTTTGT TTTGTTTTTT GC - #TTTTTAAC46500- TGCAGTATTT TGAGGAGTCT TGGAGTAGCA AGCTAATCTT TGGAAGAAAG GA - #AAATATAA46560- ACCTGAAAAC TAATAATTTA AAGAACGTCT TTTCAGGTTG TCATTTGAAA AA - #TANCTTGA46620- TTTCTGATCN ACNTGATTTG AATTGAGTGT CAAATATTTG ATATGTTTTG TA - #AATTAGGT46680- GAAGATGAGT GAGTAGGTTC TAAACTGCTT GGGTTTACCG CACTCTGGAG CA - #TTGCAGGA46740- GAATGTGATG TTGGAAGGAA GTGCTGAAAC ATAATTATTG GCTTGCCTAT AG - #GAGGGTGC46800- TACATAATTT TAGAAGGTGT CAAGAAATTG ACACAGTCTG AATTAGTTCT GT - #TGAGTTGC46860- AAAAAATGTA AAGTTTCTTG ATTCTGAAAA TAAGAAATAT GTTCCCAGAA AT - #CTCATCTA46920- GTTAATGTGC TTTTAAAATC ATTGATGTCT CTTGTTATTA CAATAATAGC CA - #TTGAAAGA46980- ATCTTTTTTA TTAGAATGTT ATTTACAGGT ACGATTAGCT TCTATTTAAA TA - #AATTATTT47040- TTATACTTGA TCTTAGGCAA AAGGCCAACA AGTGATCAGA ATAAATTATT TT - #AAGAGNAA47100- AACTAATTAT AATTGATATT TGGAATTGGA AGCACAATTT CCTTTAGAAC AA - #TTCCACGA47160- ATGGTTGTTT TGATTCTCAA GGCAGCCCAC AAAAGACAGT TTGAAACACA AT - #TTATGCAG47220- TGTCAATAGT ACTGACCTGA CTTTGGATCT TGGAGGCAGG GGCTTCAGGT GA - #TACCCGAG47280- TGGAGTTTTT ACTCCATTTC CATTCCGTAA GGCTATAGGC ATTTGAAAGA GG - #AAACTTTT47340- CTTTGGCAAC CTTCCACCTT CCTTTCTACA GAATATTTCA GTATTTCTAG CT - #CATAGGTT47400- TTCTAAAATA TTCTCTGTAA TTTATTTTGA AATGGAGTTT TTTTATCGTT TA - #CAGATATG47460- AGTAAAATTA GCCTAATCAG AATGTTAGTT CCTGAAAACA TTGACACGTA CC - #TTATCCAC47520- ATGGCAATTG AGATCCTTAA ACATGGTCCT GACAGCGGAC TTCAACCTTC AT - #GTGATGTC47580- AACAAAAGGA GATGTTTTCC CGGTTCTGAA GAGATCTGTT CAAGTTCTAA GA - #GAAGCAAG47640- GAAGAAGTAG GCATCAATAC TGAGGTATTA ATTATATATA GAATTTTCAT AA - #AGTGTCAG47700- TTTGTTCAAT TTGCATATCC TAGTACTAGA ATGCTGTATT TTTTTGAACT GT - #TATGAATT47760- CTGATATGAT TACTTTCTCT ATGTGCTACA TTTCCTTTGC TTTTCATAAA TA - #TGATCTGA47820- GAAAAGTGAT TAAAAAAAAG ACAGTAAAAG GGAGGTTTAG TCCATCTGTT TA - #GCTTATTA47880- TGTAGAATGT CAGCTTAAAT TTTACCTGTA CCTCATATTG ACCGTATAGC CT - #GGAAAATC47940- TTTCGGAGGT ATAGTTAATG GATTTAAGCA TATGGCAGTT TATGTAGTTA AT - #GAAAGTGA48000- AAACAAATTG TATTATAAAT ACCTCCCAAA CTGGTTTATT ATCATTCTAT CA - #TTCTTCAT48060- GCTCTGTTAG TATGATATTG AATATCTGAG GTACCAGGAT TATTGTTGCT TG - #TGGCTCTG48120- AGCATTTCGT AGTGCTTTTG CATGATGAGA GAAAGATTAC AAATTTAGTA TT - #ATGTTAGA48180- TGGTACGTTT TATTAAAATC AAATGCTTCA AAAATAATTG CTCTGTGTAT GG - #CATGAGAT48240- AAATAGCAAT CAGATATATT GTTTAATAAT ATGACTCTAT TAAATGATGG CA - #TAAATTTG48300- AAAATTTGAC CTTCGGTATC TTCCGGGTCT AAAATTATAT GACTCCATTA TA - #AATATTTT48360- GGAAATGATT AACTAAAAAA TTGTTTCAAT TCTTAGTTGG TAAATTCAAT GT - #GGTAGTAG48420- GTGGTGGTGA TTATTTTGTA TTAGAGAATT AGGAATTACA CTTAGTTCTA AG - #GTAATCTT48480- TATAGGATGT CCAGCAATTA AACCCCTACT TTTTTGAATT GCTTAAAAAT AA - #GGGAACTG48540- ATCTTTTTAA ATTCTGTACT TGAGTTACGT CTGTATATAT AGTCATGTCC TA - #GATAATCT48600- AATGGAACTT AATTAGTTGG AAATCTTTAT ATTGTTTATA ACTGAACTAG CT - #ATAAGAGG48660- AACATTAAAG AAAACATATT TTGAGTGGAG GTAATGAAAT TTAGCTTCTA AT - #GCTCAGCC48720- TTTTATTTCT GTAATCTATA CCAGATACCT AAGACCCTCT TATTGTTTCC CA - #GCTTCAAC48780- CTGTCAGTAT AGAAAACGGT GTAACTTACT ATTTTTTCTC AATATTGAAG CA - #CATTTGTA48840- GTGAAATATT ATTTTAACTA TATATTGCCA TTTTTGCTTT TTCCCTATTT CA - #GTAACATT48900- TTTCGCTATT TCAGTAACAT TACATGTCAA CAAGAGAATG GTGGGTATTT TG - #GGGGGGGT48960- TGGGTGGGAA GAAATTTTAC TAAGCTTGCT AGATTCTAAA AGGTATACCT TA - #TTTGGCCC49020- CTTTTCCCCA TTTAGGGGAA CAAGGGTGTT GGGGCTGGGA AGTAGATAAG AG - #GTGAAGTA49080- AGTCATCCAA AGCATATGTC TTCATTAGCC TCCCTGTATG AAAAGCTGAT TT - #CTGTAGAG49140- TGTTGGAGGC CTACTTTCAG AATCTGTCAT ATGTTAACAT TCATCTTCTC TA - #CTGACCTG49200- ATTTATATCC CTTAGTCTAT TTCATTTTAT AATTATGACA AAGGATAAAG TC - #ATTAGAAC49260- AAATTCTTTT TATTAGTTGA CGTATTGTTG TGTTTATATC TCTTGTGTTT GT - #TATTAAGA49320- TGGAAGCTCA ATCATGTCCT TGTTTAACAG AAAGGTGATG TCTTGGCATT GA - #TAATTCTG49380- ATTCAATATC CATAGGTACA TGGTGGATTC TTTAAATATT TAGTATTCTT TT - #ATTTCTGG49440- AAAGTTTTCT TAAATGATAG TTTTTTTAAA ATTTCATTTC TATAAAGTTT TC - #TTAAATCA49500- TACTTTTTAG TGTTTTATTC CATTACTTCA TATTTCTTCT TCAGGAACTC CT - #GCTATACA49560- TGTATGTTGG ATCTTCATTA CCCAGCTTCA ATATTTTTCA CTTTTCATGC AT - #TCTTTTTA49620- TTTCTTCATT TCTCTTTAAA TTTTTTTCTT CCTTTTCACC TTCTATTTCT CT - #TTTAACAT49680- AATTGTATTT ATTTCTGTAT TCCACATAGC TTAGTATTCA CTTATTTTAA AA - #TTATTTTA49740- AAACGTTTTT TAGATTTAAA AATTCTTTTT TTATTTATAT ATACATATTT TA - #TTTTTACC49800- AAAGGAGCAA CACTATTAAC TGAAGACTTC TATAATTTTT TTCTTTTATT TC - #TGATTCTT49860- TCTTCGGTTT TCCCCCTCAG TTTTGAACTT TTCTAATTTT GATTTGTGAT GT - #CCTTTTGT49920- ATTTTAGATA ATTTTCCTAA TGTTTTCCAG CTCATTTGGA AAGGCTACAG TT - #TTATTCTG49980- TACCTAAGCA AGTCTTTCTG GTGTCAAAGA TTTGACCTTG ATACTTTTCT TT - #TGCTCATT50040- TTCGTATGAG ATTAGTTTTC CTGTACTTTC AAAAGAAGGC GTGGTTCAAG AT - #GGCTTTCC50100- CAATTTCACA TCTGTCTCTA ATGTTTTTGT GTAATGTCTA AAATATGGAA AC - #TTGGTTTA50160- TGAGATCTAC TCTGCCATTT TTATCTGGGC TTTCTCTTCC TTTTGTCTCT GT - #TGTACCTG50220- TCCTGCTTGG TTCTGATTTA ACCCCAGTGG TTTCTCCTGA ATGTGGAGCC TT - #CTCCTAGA50280- AGGCAGCCTC GGCTAGTCCC AGGGTTCAGA GTAGCCAGCT GCTCTCTTCA CC - #TAAGAGAC50340- CACTGTGGAT TCCTTGTACT CACTTGCTAT TGGCTTGGAC AAAAGCCCTC CC - #ATTTTCAG50400- ATGCTATTAT CAGATTAATC TCTCATTAAT CTGTCTTTCC AGTGTATGCC TG - #TGGGCTAT50460- CTTGGGGTTC TCTTGTTATC AGACACCTCC CTGCTGGCCT CTGCTTTCTC CC - #GTACAGAT50520- GTCAGTACTG TGCAGGTCTT AATTGCTGTT GGTGGTTTGC CCCTACATTC TT - #ACAGTTTT50580- AGTTTCCCAA GGATACCTTT AAACTTGGTT TTATTGTAAA TGTCGACAAT GG - #ATTTTGGG50640- TTTTACTATC TAGTTCTGTC TTAATTCTGG AATTCAGAAA GATTAAAAGC TC - #TGTTGTTG50700- CAGCTGCTGC CACCTCTTCC CAGTACCCTC TCCTCCTATG TCATTTTTTT CT - #TCTTATTT50760- TTCTTGACTG TATAAGAGAG AATGTATGAC ATTTCCTGCT TGACCGCTGA GT - #TTGATTAT50820- AAATTAAAAT ACACAATATT TTATACAAAT TGTTTTGTAG AAGATTTATT TA - #CAGATGCT50880- CATTCACAGG TAAAATTGAC TTATGAAAAT AGTTTTCATG ACAAATGTAT CA - #GGCTCGGT50940- AACTAAATAT ATGGATTGAT CTTGTTTATA AATGAAATTA AATGTGAATG TA - #ACTTACAT51000- ATTTCTGTAT TTGCTTACAT CCGTATGTAC ACATATAATC AGCAAATGAG TT - #GATGTTTC51060- CTATTCGTAA CTTAATGGTA ATAGCTTGGT AACAGAGTTG GGAGTATTAA AA - #AGATGTAA51120- AGAGCCCCTT AAAATTTTGT TGCTGGGAAT TTTAGTGTTC TACTGATGAA GG - #AAATAGAC51180- ACTGGAAGGT GTTGTTTCTA TTAGGTAACT TAGATATCAT ACTGAAGACT TC - #AAATACTT51240- ATTGTTGACA CTCAAAAGAC ACACTTAGTG TAAGTAAGCA TTTCCCCGCT TT - #TCCCAATG51300- AAATAAGATC ATTATTATAA TTCCATTATA AATGCTGATG ATCATATTTA TA - #GAAATATA51360- GAAGATAAGA CTTGAAATGA TATTCGCTAC CAATTAATGA GTTTGAAGAA GA - #AATCAGGA51420- TGTGTTTTGC TATTTTACAT TTATTCTTAT TTAACTCCAA AGAATTCAGT GA - #TGTTATGT51480- ACTATTATTT CCATTTCTCT GTGAAGACGT TGAAGCTTAA GTAACACGCA TA - #ATAAGGTC51540- ATACATTTAG CAAGTGGCTC AATTAAAGTT CAAACCTGGT TCTGCCTGGT TT - #CAAAGTCT51600- GTGCTACTCC ATGGTATTAG GCTACAACAT GACTTAGGGT TTCTTCCTCT GC - #TCTATTGC51660- TGTTCAGATG TACTCCTCTT TTGGCAGAGT GGGAGAAAAT TTTTGCAATC TA - #TGCATCTG51720- ACAAAGGCCC AATATCCAGA ATCTACAAGG AACCTAAACA AATTTACAAG AA - #AAAAAAAA51780- AAACATTAAA AAGTGGGCAA AGGACTTGAT CAGACACATC TCAAAAGAAG AC - #ATTTATGT51840- AGCCAACAAA CATATGAAGA AAAGCTCAAC ATCACTGATC ATTAGAAAGA TG - #CAAAATGC51900- CTTTTCTGTA TGCCACCTTA TATCCCCAGT ATTTATTATT TCTAAGTCAT AG - #TATCTTAC51960- AGTGTATATA AGTCTCATCC GTTCTTTTGA TTTTCTCTTC CCTGCTTGCA AT - #TGGGTACC52020- TAGGAACAAA GTTGCAATCT TAGCCAGTTT TTTCTTTAGC CTTTGCTGAT GT - #GTGAAAAG52080- CCCTTTTTTC TACCCTGGAT TTCTGTACTT AAGCTGGAAC AGCTAAGTTT TT - #ACCTTTTT52140- TAAATATAAA GTTTCAGAGT CTTCTGCCAA GGATCTTTTG CTGTTTTCCT AC - #TGTTAAAT52200- ATTTCAAAGC CTTTTTTAAA CATAGGGAAT ATAATCAAAC ATAGCAAGCA GC - #TGATGAAC52260- AATATCTAGA TAGTCTTCAT TATTGAAATG GAATAAATGG TATTTTTGTA TT - #TTAGGCTA52320- ACAGACACCT TGTACCTTAG ATAAGGCCAA CCTTCTCATA AAATCCCTCA GT - #TACTTTTA52380- TTAATAATAA CCAAATTAAC TCTGGATTCC AGGGTGTACT CATGATGGAA TG - #ATTTCTCT52440- GTCATGTTAT CCTGAGGATC TAGTACTCTG AGATAACATA AGTGTATGAC AC - #TTTAGGCT52500- TATGAAACAC TTAGCTACTT AAATTATTTA ATTTTTTTTC ATGTGCAGAT GG - #TATTGTAC52560- CCAAACACTA CCTTTGTGTG TGTGTGTGTG TGNNCGCCTG TGTGTGTGTT TT - #TGAGACAG52620- GGTCTTACTC TGCTCAGGCT GGAGTGCAGT GGCGTGATTA TAGCTCACTA CA - #GCCTTGAC52680- CTCCTGGGCT CCAGTGATCC TGCCAAAGTG TTGGGATTGC AGGCGTGAGC CA - #CCTCACCC52740- AGCCTTAAAT TATTTTTTTT TCAAGGATGT TTAACCTGAG GGTTAGAGGC TC - #TTTGGCAC52800- GTGAGCTGCT GAAATGTGTG TGAAAGTGTT GTGCACGTGT ATGTTTCTCT TT - #TTTTCTGG52860- GAAGTGGATC TGTAGTGATT CTTAGATGAG TCTATGAGAC AAGAAACTTT TA - #TTTTTTTC52920- ATTTATTTAG CGAATGTTTG TTAAGCGTAC TATGCCTTGG CCACTCTACA GG - #GTGCTGAT52980- TGGACCAGTC TGTCTACCTA CCGTTGTAGA TGTTAGAAGC TATATTCTTT TC - #ACATGCCT53040- AATATAACTC TTTGTGTATG TATACATGCC CAGGCATGTT CCTTCCTCAG AA - #CATTAAAT53100- TCACCATTTT GGTCAACTCA AAGCAAGTAC ACCATGGGAC ACAGATCTGA AA - #TAATGTCC53160- AGATTTTTAC TTACTGAATG AGGTGTGTTG NAGTGTATAA GACTACATGA TG - #AGATGGCA53220- AGTAATTGCC TGAAGAAATG ATGTAGTGAT TTTGTGTGTC TTATATTTAT TT - #ACTTTTTG53280- ATCCAGAAAT AAATTATATA GATACCACTA TTTTGTTTGG ATGGGGGAGA AA - #GGATGGGT53340- GTGTATTCAG GAACTTATGT TACTTTTTTG CAACTAATAC CCCTTCTCAG TA - #GTACAAAG53400- ATTTGATTTC TTTTTCTTTC TATTTCCTAC AGACTTCATC TGCAGAGAGA AA - #GAGACGAT53460- TACCTGTGTG GTTTGCCAAA GGAAGTGATA CCAGCAAGAA ATTAATGGAC AA - #AACGAAAA53520- GGGGAGGTCT TTTTAGTTAA GCTGGCAATT ACCAGAACAA TTATGTTTCT TG - #CTGTATTA53580- TAAGAGGATA GCTATATTTT ATTTCTGAAG AGTAAGGAGT AGTATTTTGG CT - #TAAAAATC53640- ATTCTAATTA CAAAGTTCAC TGTTTATTGA AGAACTGGCA TCTTAAATCA GC - #CTTCCGCA53700- ATTCATGTAG TTTCTGGGTC TTCTGGGAGC CTACGTGAGT ACATCACCTA AC - #AGAATATT53760- AAATTAGACT TCCTGTAAGA TTGCTTTAAG AAACTGTTAC TGTCCTGTTT TC - #TAATCTCT53820- TTATTAAAAC AGTGTATTTG GAAAATGTTA TGTGCTCTGA TTTGATATAG AT - #AACAGATT53880- AGTAGTTACA TGGTAATTAT GTGATATAAA ATATTCATAT ATTATCAAAA TT - #CTGTTTTG53940- TAAATGTAAG AAAGCATAGT TATTTTACAA ATTGTTTTTA CTGTCTTTTG AA - #GAAGTTCT54000- TAAATACGTT GTTAAATGGT ATTAGTTGAC CAGGGCAGTG AAAATGAAAC CG - #CATTTTGG54060- GTGCCATTAA ATAGGGAAAA AACATGTAAA AAATGTAAAA TGGAGACCAA TT - #GCACTAGG54120- CAAGTGTATA TTTTGTATTT TATATACAAT TTCTATTATT TTTCAAGTAA TA - #AAACAATG54180- TTTTTCATAC TGAATATTAT ATATATATTT TTTAGCTTTC ATTTACTTAA TT - #ATTTTAAG54240- TACCTTTATT TTTCCAGGAT GTCAGAATTT GATTCTAATC TCTCTTATGT AG - #CACATGTG54300- ACTTAATTTA AAACCTATAC TGTGACACAG AGTTGGGTAA ACGATGATTA TT - #TAACTTTA54360- AGCAGTTCAC CATCCATTTC AAAGCCTTTG ATTGGCTTTT TTGTAAATAA AA - #ATAACTTG54420- TTAAGAAACA AATATATCTG TCATAGAAGA ACTAGAAAAT CCAGGGAAGT GA - #GAAAAATG54480- AAAATAAAAA NTCATTCATA GTTTTACTAG TAGCTAATCA CAGTCAACCT CT - #TTTGTGTA54540- TCCCACCAGA CTTTTTTATA TTCATTTGTT TTTAGGTAAA ATATAAAAGT CT - #CGTATATT54600- CCCATTTTTC TGCATTGCAT TACCAGAAGG TAGTGGCGCC TATTAAATAT GT - #GATATGTT54660- GTTGTCCAGC CATGGCTTCT GCATTTGCAT GCTTTTGTGT GTGCATCTGC AA - #TACCCTGT54720- GAATATCCTG TGTGATGGAG TGGCAAGTAC GCACAGACAC GTCTGCTGCA TG - #CCTAGGTA54780- CGAGGCTGTC TCCAGGAGAA GCACTTGTTT GATTATTTGA GTTGCCAATT GA - #ATTTGCTG54840- CTTTTTTTCA TGGCTTGCCA TTTTCACTGA AAAGAATGAC TAATGAAAAA CG - #ATGATTGG54900- TTATTAGATT TGGATGTTTG GCAGACATTT TCTCAAAATT GAACTAAGTT GG - #CCTCTTCA54960- CGGAAAACAA CTGGTATTTG TTGTGCCAAT GATAAAATTG GAGATTTCTA GC - #AAAATGTA55020- TAATTTTGGA AAAGTTGTGT TCCTCCACTG GAAGCTTGAC AGCTTTCCTT AA - #CATAAAGA55080- CTTCTCTTTC TCTTCGCTTT CACTACTACT ACTACTAATT CTTCTTCTGA TT - #CTTCTTCT55140- TCTCCTTCTT CCTTCTTCCT TCCTTCCTCC TCCTCCTCCT TCTTCTTCCT CT - #TCCTCTTC55200- TTCTTTCTCT CTTTCCTTCC TTCCCTTCCC TTTCCCTTCC TTCCTTCCTT CC - #TTCCTGCC55260- CGTCCGACCG CCCTGCCTTC CTTCCTTCCT TCCTCCCTCC CTCCCTCCCT CC - #CTCCTTTC55320- TTTTTCTTTC TCTTTCTTTC TTTCTTTCTC TCTCTCTCTC TCTTTCTTTC TT - #TTTCTTTC55380- TCTTTTTCTT TCTTTCAAGC AGTCCTCCCG CCTCAGTCCC CCAAAATAGT GG - #GATTATAG55440- GTGTGAGCCA CCATGCACAG CCTTACATAA AGCCTTTTCT AATGAGATGG AT - #AGTAATTA55500- ACAAATGTGA GTTTTTGATA TTATATAAAG ATTTTTTCTG TGTTTCGAAG AT - #CCGTATAA55560- CTCAGTGAAT CAGTATGTTC TGGATGACTA ATATGTGATG TTAAGAAATC AT - #GACTGAGG55620- CCGGGCGCGG TGGCTCACGC CTGTAATCCC AGCACTTTGG GAGGCCGAGG CG - #GGCGGATC55680- ACGAGATCAG GAGATCGAGA CCACCCTGGC CAACATGGTG AAACCCCGTC TC - #TACTAAAA55740- ATACAAAAAT TAGCTGGGTG TGTTGGTGCG TGCCTATAAT CCCAGCTACT CG - #GGAGGCTG55800- AGGCAGGAGA ATCGCTTGAA CTCAGGAGGC GGAGATTGCA GTGAGCTGAG AC - #TGCGCCAC55860- TGCACCCCAG CCTGGCGACA GAGCAAGACT CCGTCTCAAA AATAAAAAAA GA - #AATCATGA55920- CTGGGTAAAA GATCTGTTCA GAGTACAAGA TGGACCAATG GATTTGATAT AT - #TTGAATAT55980- AACAGAGTAT GAAAAAGTTT ATTGATATAG TTTCAGATTA CACACTGCAA CT - #AATCTTTA56040- AGAAACTATT ACTTGTCCAC TTTTTGGTAA AATTTCAGAG AACAATGTCC AC - #CATTATCT56100- GAACAGGCTA TTAAAATACT CTTCTCTTTT CCAACTACGT GCCTGTGCAA AG - #TCAGATTT56160- TTTTCATATA CTTCAGCCAA AACAGCATAT CAAAATGGAT TGAATGCAGA AG - #TAGATCTG56220- AGAATACAGC CACTTTTGTT AAGCCAGACA ATGAGATTTG CAAAATGTAA AC - #AATGCTGC56280- TGTTCTCAGT TTTTAAAAAT ATGTTTTTTA AAAGTATTTA TGTTAATGTG TA - #CTTGGTTT56340- ACTACTGCTA TTTTTAAATA AAACAAGAAA CATTTTTAAA TGTCTGTTTT AA - #TTTCTAAA56400- GTGGTAGTGA TAGATATAAC CCATATTAAT AAAAGCTCTT TGGGGTCCTC AG - #TGATTTTT56460- TTTTAAGAGT ATGGAAGGGT TCTCAGACCT AAGAGATTGA GAAATGCTGA TG - #TAATGTTT56520- TATTATAAAG GTGTACCATG AATTATGTAC CTTACTTCAT ATTGTTGGAC AT - #TAAAGTTG56580- CTTTCAGTTT TTTTGTTTTA AACAGCACTG CTTTGACCTT TTTTAAAAAA TG - #AGTCAGGG56640- TCTTGCTGTG TTGCCCAGGT TGGAGTGCAG TGGCTATTCA CAGACATGAT CA - #TAGCATGC56700- TATAGCCTTG AATTCCTGGG CTCATGTGAT ACTTCTGCTT CAGCCTCCTG AG - #TAGCTGGG56760- ACTATAGGCG TGCACCACTA TGCCCAGCTG CTTTGAATAT TCTTGAAATG AA - #ATATGGTA56820- TAGTCTCATA CCATATCATA GCCAGAGGGG GAGAGAGAGA ATTTTGTTGT TG - #TTGTTATG56880- TTATCTGTAG TGGACTTTAT GCCTTCCCAG CATAAATTCT CTCTTTCCCC AT - #TTTTCGTG56940- ACCCTTGATT TTTGTTGGGG TTCGTTCCAA GGAGAATAAT TTCCATCTGG AT - #ATTGGATT57000- GGCACCTGTG ACCTCTTCTG AGCTAGACCC TAGTAACAGC GTTTGGATCT GG - #GGTAGGTG57060- TGTGGCCAAC TGAGCTGCTG GTTCATGCCT TTCCTGAAAT GAGCCCTACC TC - #TGAATATT57120- TCAGAAACAT GGGACATTAA CTTCCCTTTA CTTACGTTAA ACCCCTTTGA AT - #GAGGAGTT57180- GTTTTTCACT TCCAGTTGTG TTCAGTTGTC ACAGAAGCAC AGCGATGTGA TT - #GGTGGAAG57240- GACCCGTCAA CAGACCCAGA AGATGTAAAG TGTTTTTAAT CTCAAAGGAT GT - #GGAATCTC57300- AGAGATAGTT ACACCGAGTA GAGGATGAAG CGGCTCCTGG ATGGAGGCAG AG - #GCTTCCTG57360- GATCTTCAAG TTCTGTATGG GTTGTTGTAT GAGGTTGGTG CAAAAGTGAG GC - #AGGAGAAT57420- AGGGTCTGGA GGCAAGGAAA CTAAGGCCGA TTCACACTGA CTTCCTAGAA CT - #AAATCAAA57480- AGGAAAACCC CAATTTTCCA GACCTAAATA ACAAAAGTAC CAGATGGCTC CT - #CCCTTTCA57540- ACTGCCCCTC CCCCACACCT TTCTGCGTGA CACATGGAAA ATTGAAAGTA TC - #TCTGGTTG57600- CTTCTGCGTA GGAATGTAAC TTTGTAACCA ATCAGACGGA TCGCAGGCCA AG - #TCGCCTGC57660- ATAGAAATGT AACTTTGTAA CTTCACTTTA GCCTCTGATT GGTTGCTTTC CA - #CAACCAAT57720- CAGATGCTTG CATAGGGTGT ACCTGTTGTG ACTTCACAAA GTGGTGGAAG TG - #GTGGAAGT57780- GGTGGAAGGG TGGAAGGGCT ATTTAAATTT TTATTCATCC TCTGATTGGT TG - #TTTCACTT57840- AAGCCTCTAA TTGGTTCTTG AGTCCTGGAG CCTGTGAAGG GTACTTTATT TT - #CAGTAAAT57900- GCATGCTTTT TTTGCTTCAT TCTTTCCTTG CTTTGTGCAT TTTGTTCAGT TC - #TTAGTTCA57960- AGACACCAAG AGCCTGGACA CCCTCCACTG GTAACAAAAG TAACTGGTGT TT - #TTGCCATT58020- AGAAGTAATG GCACAGAACA AGTACATGAG AGCGATTTCT TATGGAAAAT TA - #AATGGCGC58080- ATAAGTCGTG TGCTCAGGTA AGGGAGCTGG GAACCGGTAG AGGAAGGTCT CC - #AACCCACA58140- CCCGTGGGAT CTCTGAGTCT TTGAAAGTCC GTCCTCACCC TTTGTGAAGA AT - #GGGAGCAC58200- GGCTGGACTC GTCACCGGGG GTTTTGGGGG GCTGAACTTG TCATTTGAGG GT - #GTAGGGAG58260- GTTGGATGAA TCGCAGGGGT GCAGGGAGGG GGCCCACTGG AGCTCCACCA GG - #ACCCCAGC58320- ACCCTAGATC CAAACCTGGT CATGCTTCCC ATGCTCAGAG GCAAATCTCC CT - #CCCCTTGG58380- GGGGCGGAGT CAGACGAGAC CCCCTCTCCA TCCTTTTCCA GGTCCGGTGG GG - #GCGGGACT58440- TTAAAGGTAA AAACAGCAAT TACTTTTGCA CCAACTTATC TTCTAAGTTT CG - #CTCCCTAC58500- CACCTGAGTG TGTTTGGAGG CTCTGGCTCA TTGTACCTGC CTGATCACCA GG - #TGCAAGTA58560- GCTGGGCCAG AAGGACCTCG GCACGTTACG GAATATTTAC TACAGGAACA GG - #TGAGCTGA58620- AGGCGAATTC CCCAGGTGTA GCCTGTGACC ATAGATTCAG ACAAAGCCCT GA - #CTGTTGCC58680- TGGAATTCAA AAAAGCTGTA GCCCTACCAG ATAGAATAAG AAAAGAATAT AG - #GATTCTTC58740- CTATTCAAAT AGGTTGCATA TAATTAAGAG CATGAACGAT CCAATGGAAT GA - #ACTCAAAG58800- TAGTTTTTGA GTGTAATAGA CTTGAAGTGT CTTATGGAAA AGAATTGCAA AA - #CCACAGAA58860- ACAGTGAAGA AGGTTAGTTA TAGCCTTGAT GGGGTAGCTG ACTTCAGCAG TC - #TCAGCTAT58920- CTGAAAAGTT ATTTACCAGA TTTTGGTTGG GAACATAATC CCTAAATCAT TT - #GAGATAAT58980- GTACTTGTTT CCTTACTGGG TAAATGTGTT TAAACCTTGA GNAAAATGTA GA - #CATAAGTA59040- GNAATATANG AATAAATTAA ACCTTTGGTA GTTATGTTTT AGGATTAAGG AC - #TAATAAGT59100- ACATATTTGA TATTTAAGCA TTTGTAATGC TTGAGATAAT TTATCCTACT CA - #AGTAACAG59160- ATTACTCTTG TGACTCCAAT GTAAAATATA TCATTGAAAA ATTAGTATCT GC - #TTGTGATT59220- TTTAAGTAGA AACCCTGCCA TTTGAAAGGT ATTTGCCTTT ATTATTGGAG AT - #ATTTCATA59280- TGAATGTTTA ACTTTGTTAT TGCATAGAAG TATTTAAACA GATTTCACTT GC - #AAGAGAAA59340- GATATCTAAT AGGTTACTCT TAATCAGTAC TAAATTACTA CAATTACTAT AT - #TCTATTAA59400- TATCGATTCA TTAAAACCCA GAGCTTTAAT TATGTCTCAG AAAATTAATT AA - #ACTTTAGC59460- CTCATAATCA GCTTTATTTT CTAACTCAAT GTTTAAAAAT TGACAAGTAT GT - #ATTATACT59520- TATTTATGTC TTCATTCAGT AAACATTTGC ATTTGTAGCA TGCAAGACAA CA - #TGCTAGAC59580- ACACGAAAGA TGGAATAAAT GGAAGAAAAT GCAACACAGA TCTCATGCTT AA - #GAGGGACA59640- GATTTACTCT GAAGATTCAA TGAAAAAACA TCCACAAACA ACTTTTCTAC AA - #GAAACAAA59700- ACATTTTAAA GAAAACATTT ACTTCAGCCG GGCGCGGTGG CTTACGCCTG TA - #ATCCCAGC59760- ACTTTGGGAG GGCGAGGTGG GTGCATCACG AGGTCAGAAG TTCGAAACCA GA - #CTGGCCAG59820- TATGGTGAAA CTGTGTCTCT ACTAAAAATA CAAAAATTAG CCTGGCGTGG TG - #GTGTGTGC59880- CTGTGATCCC AGCTACTCAG GAGGCTGAGG CAGGAGAATC GCTTGAACCT GG - #GAGGCAGA59940- GGTTGCAGTG AGCTGAGATC AGGCCATTGT GCTCCAGCCT GGGCAACAGA GC - #GAGACTCC60000- GACTCAAAAA AAAAAAAAAG AAAAAAAAAA AGAAAACATT TACTTCACAT AA - #TAAGATAT60060- GAGAAAAAAT GGACTCTCTG AATGAAAAAA AGAGGAGATC ATGTGAAAGA TT - #TGCGCTTT60120- TTTTTTTTTT AAAGTTATGG ACTGAAACAC TCCTAATCAT TAACATTTGT TA - #TTTTAGGG60180- GAGTGGAATT GGAAAGGTGG AAAGGGCTAT TTACATTTTT ATAATCTCCA TG - #TCTTTTAA60240- ATCAATATAT ATTGCATTTA TTCTTTTAGT TAAAATTTTA AGAACTCTAT AA - #AAAATAGA60300- GACAGGGACT CCCTTTGTTA CCCAGGCTGG TCTCAAACTC CTGGGATTAA GT - #GATCCTCC60360- CACCTCAATT AGAAGGGTGG AAGGGCCAGC TGTTTAAGTT TCTATAATCT CT - #GTTAAATC60420- AAATGTATAT TGCATTTATT ATTTTAAATT TTAAAAACTT TTTTAAAAAT AG - #AGATGGGA60480- TCTTCCTATG TTGTCCAGGC TGGTTGTGAG CTCCTAGGAT CAAGTGATTC TC - #CCGCCTTG60540- ACCTTTCAAA GAGCTGGGAT TACAGGCATG AGCCACCATG CCCAGCCTAT TT - #ATTTGTTT60600- ATTTATTTTT AGAGGCAGGG TCTCACTCTC ACTAGACTGA AGTGCAGTGG TG - #TGATCATA60660- GCTCACTGCA GTCTCAAACT CCTGGACTCA AGCAATCAAC TAGCCTCAGC CT - #CTGAGTAC60720- TGAGATGACA GGCATGTGCC TTCATACCCA GCTAATATTT TTGTAGAGAT GG - #GGTCTTCC60780- TGTGTTGCCC GGAAGAGTCT CAAACTCTTG GCCTCAGCCT CCCAAAGCAC TG - #GGATTGCA60840- GGCATGAGCC ACAACACATG GCCCTGCTTT TAAAAAATAT ATAGTGGGCC AG - #GCTTTCTG60900- GGATGATGGG CAACCATTAC ATTTGCTTTC TCTCCATTCT GAATGTCAGC CT - #CCATACAC60960- CTCTCTTGAG CCATCTCTTG ATGCCCAGGA CTGGCAGGCA AGCAGGATGT TA - #GGGTGCTG61020- GCTGGAGGGC TGGAAAGCCC CAGGGCAAGG ATATGAACGT GAAGGATTTT AA - #GGAGATTC61080- TTGGACCTCA AGGGAACTTT TGGTCCTGGT TTCCTAGAGT ATGTTAGATC TT - #CTTGGCCC61140- CCAAAGAATC AAGGAAAAGC TGAATAGGTG GACCGAATCC TTTCCAGCAC TG - #AGGCTGGG61200- AGAACTCTAT GACACCAGTG GGTGCTCATC CTGGTGCTGC CATGGACCTG AC - #TACCTACT61260- TCCGCTAAAC TCTCCAGCAG CTGAGCCTTC AAGAGAAGAC GTCCTCCACC TT - #TTCCATGA61320- GATGAAGAAT CCTTGGGGCC AGGGGATGTG CTCACTAGCT CACACCTGTC TC - #CATCCTCT61380- AGACCATGCT TGCAGTACAC AGGACCCCAG AATGCCTGGC CCAAACACTC GT - #GAGCCTCC61440- AGGGGCTGCA GGGGCTTCTG GCCTTGTTTC CCCATCTGAT GAGTTCGTTT CT - #TGGTCTGA61500- AAGATTGTGA CAGTTACTAC GAGACTGAAT GAAGGGGGAT GAATGCAGAA AT - #GAAAACTT61560- AAGACAAAAG TAACTTTTAA TGAGAGGGGC CGAGGGAAGA AGAAGAGGGC TC - #CCTGCTTC61620- TAATGAGCAA AGGCAGCCAC CCTGAGCTTC TACAGCCCTT CGTATTTATT GA - #GTAGAAAG61680- AGCAGGGAGG AGGAGGTAAT GATTGGTCAG CTGCTGGATT GATCACAGGT TC - #ATATTATT61740- GCTAACAGGC TTCAGATGTG CCTGATCACA AGAAACACTT GCGCCTGGGC AT - #GACTGCCC61800- TCAGCATTCC TTCTGGGCGG CAGATGCAGT TTGTCAGTTT GCTAACAACC TG - #CTTTCATG61860- AGAACAGTTT GCTGCTTACT TACACAGCCA CCAGTGATTT ACTGAGTTGA TC - #ACGACCCT61920- CACTCTTTCG GCCTCCAACA AAAGACGATC AAAGAATGGT TGTTTGCAGA GG - #TTATGGAC61980- AAGACTTGAT GTCCAGGCCG AGTGTCCGTA TGCACAGGAG CCTCTTGGTG GT - #GCAGAGTG62040- AAGCCAGAGG AGGAGGAGTG GGTTGTGTCC ATGGGCTGAT TCTCCCTGCA CC - #AACAGGAC62100- AGAATCCTAA GGAATCCGAG CATTTGAAAT TCAAATCTGG TCTTACAGGT TG - #TTATGTAT62160- TTGTCTAGGT AGGAGGCTAG AATGTATTGA AATGGGGTTA GCCTGACATA TT - #TATATATT62220- TCATATTTAG GCTTCCATTT GTTCCTTTGT CTTGGGTCCC AAAAATATAT TA - #GAGGTGGG62280- CCTGTCTGTT CTCTTGGACA CGAGGACCTC AACGAGTTTC CACTGTTCTC TG - #AATGTTTC62340- CTTCCTGGTT TTCTGTGTAT ACAATAATTC CTAGTTTTCT GTTATTTACA AT - #TTTACTTC62400- CACTTTTTAA AGACAAAAAT GTATGTTTTT TTAGTCAATA TTGATATAGT GG - #ACCAATAT62460- ATTTTACCGT TATTTTTGCT TACTGTTTTT GTTTTTTTGC CTTCCTCATC TT - #CTCACTAA62520- GTTTGTCTGA CTACAGCCAC ACACCATTCA TTCAATACCA ACTCTTTTTT AT - #TTTTATTT62580- TTTGGAGAGA GGGTCTCACT CTGTCACCCA GGCTGGAGTG CAGTGGCATG AT - #CTTGGTTC62640- ACTGCAGTCT CAAACTCTTG GACTCAAATG TTCTTCCTGC CTCAGCCTCC TG - #AGTAGCTG62700- GGACCACAGG TGCACACGAC CATGCCTGGC TAATTAAAAA CAAAACAATT TT - #TTTTTTTT62760- TAGAGACGGG GTCTCACTAT GTTGCCTAGG CTGGTTTCAA ACTCCTGGGG TC - #AAGTGATC62820- CAATACCAAC TCAACACGTG GTGAGACCCA GTGGTCTAGA CAAACAGCCA CA - #TAGCAATA62880- TGTTTTTCTC CATGATTCAT ATCCATGTTC GTTTGTTACA AAATAACAGG CA - #TGAACATT62940- TTCTTCAGAG AGGGAGATCC CCACTTATCC ATTAATGACT CATTTGGTGT CC - #ATTCCAAA63000- CTATTAAACT GCAAAAGCAG ACATGAGAAA AGAAACTTAA GTCAATGTTT TT - #ATCACATG63060- TTGGTGCCAG CCTCCCATAG TGGTGCTAAA TTTATGNAAA TTGCAACAAA AC - #AAAAACCC63120- AAACAACCCA ACAACGAAAA GCTATTTAGT GAACACCGTG ACTAACAAGC TT - #ATTAGAAC63180- TGCTTATCAG AGCTATGTGT GGATTTTGTA GGGGGAAAGA TTTTCTTCCC TC - #GTAGACAT63240- TTTGCAAAAT AAAAGTAAAA TATTACCTTT ATGTACGTGG TAGATAGAAT TC - #CACAAGCT63300- TCAAATTCAA CGACTCAAAA ATGTTGCTTT TACTTTCCAT ATCTCAGAAG TC - #ACTTTTCT63360- TTTATTTATT TTTTAGAGAT AGGGTCTCGC TCTGTTGCCC AAGCTGGAGT TG - #CAGTGGCA63420- CAATCATAGC TCACTGCAGC CTTGAACTCC TGGGCTCAAG CAGTCCTCTT AT - #CTCAGCAT63480- CCTGAGTAGC TGGGACTACA GGCGCATACC ACCACTCCTA GCTGATTTTT AA - #ATTCTGTG63540- TAGACATAGG ATCTTGCTGT ACTGCCCAGG CTAGTCTTGA ACTCTTGGCC TC - #AAGTGATC63600- CTCCCACCTT GGCCTCCTAA AGTGCCGGGA TTGCAGGTGT GAGCCACCAT AC - #CTGCCCAG63660- AAATCTCTTA TTTTAAACCC CAATTCCTCC TGATAGTAAA AAAAAAAAAA AA - #AAAAAAAT63720- GTCATCTTGG TGTATTTTGG GTAGGCTGGA TCACTTCAAG TTTCCCCCTC CT - #CCTGAAGC63780- TCCGACAGAG GCCTGCAAGC CCTGCTGGGA TCTGTCCTCA GTCCCTCTCG GG - #CTCATCTT63840- CTACCATCTT GCTGTCACTC CATCTCCCTG TCCTTCCCTT TGCTTCACCC AT - #ACCAGACC63900- CTGTACTGTT TCTGGAAGAC ACCAGGCATG CTGTGTCTTA GGGGAGAATG TG - #ATTTCACC63960- AACTAGTGCC GCCCAAGTAA CATGCATTTG CCCTGACTGC TCTTTTCACC TG - #CTGTGCTG64020- CTCCCCCAGA TAACCACAGG CAAACCCCGC CAACTCCTAG TTTATTGAAC TA - #TACCATGA64080- GTAACTTACT TAAAATCTCC ATACCTTGTC CCATTCTCTC TTACCTGTTC CA - #ATACTTAT64140- TTATGATGTT GATAGATGAT CTCCCTCTAC TAGACTGGAA GCTCCTTGAC AG - #CGGGGATT64200- CTTGTCTGTT TTGTTCACTG CTGTGTCTTT AGCACCTGGA GAAATGCCTG GC - #ACACAGCA64260- GGAACTCAGT AAATAACTGC TGAATAAATA AACATGAATA AATCAATGAA TG - #GGGATGCC64320- TAAGTGCTTC GGGATTCTGG TCAAAGCTTT GGCAACTAGG GACGCACAGG GA - #CCCTCATC64380- ATCTCTGCCT CCTAGGCAGG TATCCACTGA GATCCGCAAT CCCATCTGGT CC - #TTGGACCA64440- GTTACCCTTC ATGTTGGCCT CTGTTAAGAT GTCCAGGTTG TATCTGGTCT CC - #CACACAGC64500- ATCCCTTTAT TACTACCCCT GGACCTCAGC AGTCAGCCAC ACATTCAGTA AA - #GGCCACAG64560- CTCTGCCATC TCCTAGCTAG GGGACTTTGG ACAAATTACT TAGACACTCT GA - #GCCTCGTT64620- TGTAACATGC AGAGACGTTG CTGGGATTAG ACACAATGCC TGTAGACCAT TT - #AACAATTG64680- CTGTCACACA TGGTTGGTAT TCACTCAGCT GTCGCTATGG AATTAGCAGA CA - #GAAAAGGC64740- ACAGCGTCAG TGGCTGGGTG TCCAGAGAGA AGCAGCCTGT CTCTCTAGAT AA - #TACTTGGC64800- AAAATCACAG CAGTCCGGTG TGTGGCCCTT TACTGACCTT GATTAAAAAT CG - #GGTGTCAG64860- CACCCCAAGT GGATCCTTCT TACAGGTGCA GATTCAGACT CATTATCCAA GT - #TGACAGAG64920- ACAGAAGTAA ATATTCAACA AATATTTATT GAGCACTTAC TATGTGCCAG GC - #ACTGTTGT64980- TGTAGGTGCT GGAATACAGC AATGAACAAA AAAAGTGAAA CATTCTTCCT TA - #GATGGTGG65040- TAAAGCGATA GGAGGACACA GCAGGGAAGG GGTTTGGACT ATTTCAATTT GG - #GACAGGAA65100- ACGCCTTGCT GAGAGAGTGA GGGTTGAGCT CTGGAATTAG CCTGAGTTTG AC - #CACATGTA65160- ACTGCAACTT TGAGCAAGTC GATCCACTGT AAGTCTCTTT TATTAACACC AT - #TGTGTGTA65220- AGAGGAAATA GAAACTCAGC TAAAGTCGTT GGAGAATTGA ATGTGGTGCA GC - #ATTTAGCA65280- CAGCGCAGGA ATAATAAAAG CCAGCTGTTC TCATCCTTTG CCCATAGAAA AG - #CTATCCGG65340- GAAGCCACAT TATAGTCTGA AGGCTGCCTA CTGGTTTGGT CAAAGAAAGG GC - #AGTTAGAT65400- AATTTTCATG TTTAATTAAG GGCACGGGGC TAGATTTCTT GAGGTGCCAG AG - #TAATGCTT65460- GCTTTTCATG AACAACGGAT ACAAGATATG GGCATTGCAG AACCTTTAAA GA - #ACATAACT65520- GGAATAATCA AATAACCGAA AGTTCATGAA ATATTCTGGC TCATGAATTA GT - #TATCTGGT65580- AAATCACAGT CTGAAAGTCA CAGAATACAA ATTACTTTAA ATTTCCTCCA AA - #GCTTACTG65640- AGTAAGGGGA GGGACATTTA AGATGCGGAG GAAGCGCTGA ACTTGCAAGA GG - #AACAAGGA65700- GGACGGTGGC TGCTGGAACT CTGTAACCCT TAGAGAAGAT GTGGGTGGGA TT - #TGGCAAGC65760- CCCCTAGACT CTCTTTGTTT TGGGTCTTAA TAGGGACAGT TTATTATTTT TA - #ATGACTCG65820- CGTGAATTGT ATACTGTTTT AAGCATCCAC CAAAAGCCTT TCGGCTTTTT CC - #CTAATTAG65880- ACTCATTCTC ACACAGAGAG GAACTGAACT TTTTACCTCT TTGGTTCAAG AG - #CACCATCT65940- ACTGGTCAGA TTTGGTAATT TCGGGTTTAT GGCACTGGAA AATCAAAGAG CA - #TTTTGATT66000- TGGTTGTGTT TGGTTTTGGT CCATTTATCA ATACAGGTTT TTTGGCGGAC AA - #AATAATGT66060- GAAAATCAGG GGAATCAGGT GAGGGCATTG GATGTCTCTG TCACAGACGA TG - #GGGAGCTC66120- AGCCGATTTT AAGCTTCTAA CCTCAGCTGG TCTGGAGAAG AGCAAACCTG AC - #AACCAGCA66180- CGAAGAAAGT AGCTCTGCCT CTGTGGTGTG CTGGACATTC TGGTTACATA GA - #TGGGAAGA66240- CGAGGCCCTT TCCGACAAAT ATGCAAATCC CCCACATCTC CAAATTTGGT AG - #CTCTGGGG66300- CTTAGGGCAG CTTCTGGAAA CAGAACTCAG ACCTAGCCTG CTGGAGCAGG AA - #GGGCTTCT66360- GAGAAGATGA TATCTGGACC ATCTAAGGAG TGTAAATAAG AAATAGCCGC CA - #GGCATGGT66420- NGCTCACGCC TGTAATCCCA GCACTTTGGG AGGCTGAGGC GGGCAAGTCG CT - #TGACAAAG66480- TCAGGAGTTT GAGTCCAGTC GGGGCAACAT GATGAAACCC CATCTCTACA AA - #AAATACAA66540- AAATTAGCTG GGTATGGTGG TGCATGCCTG TAGTCCCAGC TACTCTGGAG GC - #TGAGGTGG66600- GAGGATCACT TGAGCCTGAG AGGTTGAGGC TGCAGTGAGT CGTGATGGCT GC - #ACTCCAGC66660- CCGGGCAACA GAGTGAGACC CTATCTTAAA AAAGAAAGAA AAAAGGAAGA GG - #TCAGGAGT66720- TTGAGACCAG CATGGCCAAC ATGATGAAAC CCCATCTCTA CTAAAAATAA AA - #AAAAAATC66780- AGCTGGGCGT GGTGCATGCG CCTGTAATCC CAGCTACTGG GGAGGTTGAA AC - #TGGAGGAT66840- TCCTTGAACC CGGGAGGCGG ACGTTGCAGT GAGCCGAGAC CACACCACTG CA - #CTCCAGCC66900- TGGGCGATAG AGCGAGACTC CACCTCAAAA AAAAGAAAAA AGAAAAAGAA AA - #GAAAAGAA66960- ATAGCCAGAT GGAGAACAGG GGAAAGGCCA GAAGAGCAGG GGCGTAAAAG GC - #GTGGAATG67020- GCATGCGGGG GAGTAACAAG GTTTTTTTTT TTTAAACGGA GTCTCACTCT GT - #TGCCCAGT67080- TTGGAGTACA GTGGCGCGAT CTTGGCTCGC TGCAACCTCT ACCTCCCGGG TT - #CTAGCGAT67140- TCTCCTGCCT CAGCCTCCTG AGTAGCTGGG ACTACAGGCG TGTGCCACCA CA - #CCTGGCTA67200- ATTTCTGTAT TTTTAGTAGA GATGGGGTTT CATCATGTTG GCCAGGCTGG TC - #TCGAACTC67260- CTGACCTCAA GTGATCTGCC CGCCTCAGCC TCCGAAAGTG CTAGGATTAC AG - #GCGTGAGC67320- ACCGTGCCCA GCTAGTAACA AGGTATTGAC TGAACCAGAG TGGGGTGTGT CA - #AGATCGGG67380- AATCAGCAAG CAGCACAGGG GGTGTCCTGG GTGGGGATCT GGGGCTCAGG TC - #TTCCTGCT67440- ATCCTGCTAC CCACCTGCAC ACTTGTTCGT TTTCTTTCCA CTCATTTTTC TC - #CCTTGCCC67500- AGACTTCAGG TCTACCAGCT ACACTTCTTG ATTTCTTTGG CCTTCAAAAT TC - #GGTTCAAT67560- AAGGAAAGTT TTAGCATTAT TTTCATATAG GTCCTTGACA TTTCTTGCTA AG - #GTTATCAT67620- TAGATTTTTT TTTAATGGTG TAATAGTTCA GGCCTTCACT CAAATGTCAT CT - #CTCTAGAG67680- AAGCCTTCCT TAACTACCAT ACCAAAAACG GTTCCAGCGC CGCTACCGTC TA - #TCCCAGCC67740- TATCCTCTCA CGTCCTGTGG TCCTGAGGTT CTGTGATAAT GTTCTATAAT TC - #TGTGCTGT67800- CCAATATGGT AGCCACGAGC CACATGTATT CATATCGTCG TTATTGAGCA CT - #ATATAATG67860- TGGCTAGTGC AATTGACACA CTACAATTTT AGTTGAATGC AATTTAAATT AA - #TTTACATT67920- GAAATAGCCA CATGTTTGGC TCACACCTGT AATCCCAGCA CTTTGGGAGG CT - #GAGGCGGG67980- TGGATCACCT GAGGTCAAGA GTTCGGGACC AGCCTGGCCA ACATGGTGAA AC - #CCCATCTC68040- TACTAAAAAT ACAAAAATTA GCCGGGTGTG GTGGCACGCG CCTGCAATCC CA - #GCTACTCG68100- GGAGGCTGAG GCAGGAGAAT CACTTGAACC TGGAGGGTGG AGGTTGCAGT GA - #GCCAAGAT68160- TGCACCACTT CACTCCAACC TGGGCAAAAG AGTGACACTC TGTCCAAAAA AA - #AGAGAAAT68220- AGCCATATGT GGCTGGTGGC TATTGTATTG GACAGCACAG CTCTGTTTCT CC - #CACTAGAA68280- TGTAATTTGA TGAGGGTGGG GACTTGGACT TATTCACAGC TGAATACCTA GA - #ATGGAACA68340- TAACTGCTAT GTTTTGAATG TTTGTGTCCC TTCCAAAATG TATGTTGAAA CT - #TAATCCCC68400- TATATAAGAG TTGAAGAACC TTTTAGAAGG TAATTAGGCC ATGAGGGCAG AG - #TCCTCATG68460- GATGGGNATT AGGGTCTTAT AACAGGACTT GAGTCCTCTA TAANGGAACG GA - #GAGTTCAC68520- CTTTNCCTTC CCTTCTGCCN ATGTGNAGGA CACAGCGTGT GTCCCCTCTG AA - #GGACACAG68580- CGACAAGCCT CCATTTTGGA AGCAGAGAGC AGCCCTCACC AGACACTGAA CC - #TACTGGCG68640- CCTTGATCTT GGACCTCCAG CCTCCAGAAC TATGAGAAAT AAACTACTGT TG - #TTTGTAAA68700- TTGCCCAGTC TGTGGCATTT TGTTATGAAA ACAGCAAAAA CAGACTAAGA CA - #AATCAGTT68760- CTGGCACATA CTAGTAACTC AGTGATTCTT TGTAGAGTGA GCAAACGTGT GA - #ATGAATGA68820- ATGAATACAT TGTCATGCGC AGCTTTCGTG GGTCGTGAGT ACAAATGAGA AA - #ATACGATC68880- ATGGTGCCAT TGCAATGGCT TGAAACCCCA GCACTTACTG GCAGGAAGTC TG - #TCATTTTT68940- TGCAATTCTC CTTCCCAAGT GTTTCCAGAC TCCCGAGAAG TGCACATGTA TA - #TTTAGGAA69000- TCAGTTCTCA TCTGCTAGAA CATGGGAAGG GAGTTAGTTG ATAGCAGTTC AG - #CTGCTTCA69060- AATGCAGTCC TAGCTGACCC TGGAGGATCC AGGTACCTAT GGGTGCCATC AC - #GGCCACCT69120- TTGCACTATC CTGTGAGAAA CTCTCTCCCA TCCTTGGTGA TGTCCTCCTG TG - #GTAACCTC69180- AGTGAGAGAA CTCCATTGAT TCCCTAAACC AGAGGTCCCC AACCTTTTTG GC - #ACCAGGGA69240- CTGGTTTTGT GGGAGACAAT TTTTCCATGG ACCATGGGTG GGGAGGGGGG GA - #TGGTTTTG69300- GAATAATTCA AGTGCATTAT AATACGTTTA TTGTGTACCT TGTTATTATT AT - #TACATTGT69360- AGTATAGAAT AATTATACAA CACACGATAA TGTCTAATCA GTGGGAGCCC TG - #AGCTTGTT69420- TTCCTGCAAC TAGACAGTCC CATCTGGGGG TGATGGGACA CAGTGGCAGA TC - #ATCAGGCA69480- TTAGATTCTC TTAAGGAACA TGCAACCTAG ATCCCTCGCA TACACAGTTC AC - #AATAGGGC69540- TCATGCTCCT GTAAGAATCT AACGCTGCTG CTGATCTGAC AGGGGGCGGA GN - #TCAAGTGG69600- TAATGTGATG GATGGGGAAC TGCTGTAAAT ACAGTTGAAG CCGCTCACCT CT - #TGCTTTGT69660- GGCTGGGGCC TGGGTACCCC TGCCCTAGAC AGTAGACTTC TCAAGGGGAG GG - #GAAAGAAT69720- GGGCCAAGGA ACTGTGTCAG TCAAGAGGGC CCCCACTCAA CGGAAACAGA CC - #AGCCACTG69780- GTCTCACAGT GCAAGTCAAG GAAGCTGGTC TCAGAGCTGT CCTCAGAGGG GA - #CGCGTGAT69840- AAGCAGATCA CACCCGGGAA GACTCGGCAT CAAGATGGAG AGGAGGGAAT GC - #GATGCGCC69900- TGGTGGCAGC CGTAGGATCT CCTTCCAAGG CCGCACTGGA GGAGAGCTGC CT - #CCTAAGAA69960- CAGGAAAGTG AATCAGAGTG AGGCTGTCAT TATAGTAAGA TAAAGAAAGA TG - #AGTGCTTG70020- TTTGGGAATC TGGACAGAAT TAGCATCTGC TTGCTTTAGG ATAGTGGCTT CT - #TTTCTCTC70080- TTGAACAAAA TACTCTCCTT AATAACTGCA GACCCAGGAT AACATGGAGT CA - #TTGTTCAA70140- ATTCACCCCG TTGCAGAATT CTCCAGTTAT CAGCATTTGT GTGTGTGTGC GT - #GTGTACCT70200- ACATGTGCAC AGATGTATAC ACACACAGAT AAACACACTC CAGGCTTTGG GG - #AAATCGTA70260- TTCGTAGATG CCTGTCTCTA CCTTTATTAT GTTAAAGAGA ATTCTGACTC TC - #AGGTCGTG70320- GACTTCATTC ATTGTGTTGC TCACATGCAG GAAAAAAAAA AACCAGAATG CA - #ATAAGGAT70380- AATTCATTGA TTTGTGGGGA AAGAGAAAAT TCATTGTTTT GGGGGGAAAG AG - #AGAATGTA70440- TTGATTTGTG GGGAAAGAGT CAATAAGTGA ATGTTTCCTG TTCTAGGACT GG - #CTTTGCCT70500- TGTCAATAAT TGATTTTGTT GTTGAGAATA CATTTCAAAG CCTTTAAAGC AG - #TGTGCAGT70560- TAAGGATGAT ATTTTTGCTT GAAATGACTA CTTTGCATCA TGTAGAAGGA AT - #AGTGTCTT70620- TTAAAGGCAA CAGATGCAAG TCTAGGACCC CAGAGCTTTA GAAGGCTCTG GG - #CTTCGGGT70680- ATGTGTCTGA TGTGTTGAGA GTTGCAGGGG ACGGGAGGGA TGTCCACTGT GG - #GCCAGTTT70740- CTACCAGCCA CCGAGAAGCT GGAATTTGTT TATTCATTTA TAGAGCAACA GG - #AACTGGAA70800- TCGAAATCTG TCAGTCCCTA TGTGCAGGGT GTAATTGAAT TGACTTCTCT GC - #TCTCAATT70860- GGAACTTCCT TTGACCTGTA GTGAGAACAT TTTATGGCTC CCTCTAATCT AA - #AAAGGGTT70920- TTTTTTTTTT TTTTAACTTT CCTTCCTATT CCCTTGTCTG CTAACCAACA GA - #GAACTCAG70980- CCCACAGCCT CACAGACAGA ATGAGAGCAA TGCTTAATCC TTGTTCAGTG AA - #TCTCATGG71040- CCTCCTCTAG TCTTCAAACT TGGATTCCAA GTGCCTTGAA GAGCCAGACA CA - #GTGGCTCA71100- TGCCTGTAAT CCCAACACTA TCGGAGGCTG AGGCAAGGGT GGATCACTTG AG - #ATCAGGAG71160- TTTAAGACCA GCCTGGCCCA CATGGCGAAA CCCTGATTCT ACAAAACATA CA - #AAAATTAG71220- CCAGTCCTAG TGGTGCATGC CTGAAATCCC AGATACTCCA GAGGCTGAGG GA - #GGAGAATC71280- ACTTGAACCT GGGAGGTGGA GGTTGCAGTG AGTGGAGATC GCACTACTGC AC - #TCTACTCT71340- GTCTCAAATA ATAATAATAT ATATTTTTAA GTGCCTAGAA GAAAGAACTG CA - #CTTCTGCA71400- GAGAGCGCCT CCAAAGCTCA GGGTAAGTGA CATGCTGCTT ACCATCCTAG AA - #TGGAACCA71460- GGCCACCCAT CCCCAGGTGG GACAACTGCA CTCCCAGGAT AACCCCTGAG TT - #ATGGGCAG71520- ACTTGTGTCT CTCCCCAGTT CAGATCTTGA AGTCCTAGAC CCAGTGCCTC AG - #GATGTAAC71580- TGTAGATTCT TTAAAGAGTG AATTAAGATG AGGCCATTAC TAAAAGCCTA GA - #CCTGACCA71640- CTATGCAATC TATGCATGTA ACAAAATTGC ACATGTATCC CATCTCTACA AA - #TTAAAATA71700- AATAAATAAA ACTACGTCAT TACAGTGGGT CCTAATCCAG TATGACTAGT GT - #TTTTGTGT71760- TTGTTTTTGT TTTGAGATGG AGTCTCTGTC ACCTAGGCTG GAGTGCAGTG AC - #ACGACCTC71820- GGCTCACTGC AACCTCCACT TCCCAGGTTC AAGCAATTCT CCTGCCTCAG CC - #TCCCGAGC71880- AGCTGGGATT ACAGGCACGT GCCACCACAT TCAGCTAATT GTTTTGTAAT TT - #TTTTTTGA71940- AGTTTTTATT TTTTATTTAT TTATTTTTAA TCTTTTTTTA TTTTATTTTA TT - #TTTTTACT72000- TTAAGTTTTA GGGTACATGT GCACAACGTG CAGGTTAGTT ACATATGTAT AC - #GTGTGCCA72060- TGCTGGTGCG CTGCACCCAC TAACTCGTCA TCTAGCATTA GGTATATCTC CC - #AATGCTAT72120- CCCTCCCCCC TCCCCCCAAC CCACAACAGT CCCCAGAGTG TGATGTTCCC CT - #TCCTGTGT72180- CCATGTGTTC TCATTGTTCA ATTCCCACCT ATGAGTGAGA ATATGCGGTG TT - #TGGTTTTT72240- TGTTCTTGCG ATAGTTTACT GAGAATGATG ATTTCCAAAT AGAGACAGGG TT - #TCATCGTG72300- TTGCCCAGGC TGGTCTCGAA CTCCTGACCT CAAGTGAGTT GCCTGCCTTG GC - #CTCCCAAA72360- GTGCTGGGAT TACAGGCGTG AGCCACCACT CCCCGCCTGG TGTTATTAGA AG - #AAGAGATT72420- AGGACAGAGA CACAGACACA GAGGAAAGGC TGAGTGAGGA CACAGGGAGA AG - #ACAGCCAT72480- CTGCAAGCCA AGGAGAGAGG CCTCAGAAGA AACCAACCCT ACTGACATCC TG - #AGCTTGGG72540- CTTCCAGCAT CTAGAAACTG TGAAAAAATA AATGTCTGCT GTCTAAGCCA CC - #CAGCCAGT72600- GGTATTTCGT TGTGGTAGCC CTAACAGACT AATACATGCT GAGTCTCTCA TT - #GTTCAAAT72660- CATCCTGTAA AACTGACTCA ACAGGCTTTT TTTGAGCAGG GTTTTCTATT CA - #TGTACTCA72720- TTAATTTTCC TTAAATTAAA AGTTGCAAAT ACAATATACA AAATTAAAAG TT - #CAATTAGA72780- AAAATGAGTT TCTATAATCA GCCTACTCAG AATTAACCAT GGTTTCAAAT AG - #GGGTTTTG72840- CTGGTGTTTT TTGTTTTGTT TTGTTTTGAG AGAAAGTTTT GCTCTTGTCT CT - #CAGGCTGG72900- AGTGCAATGA CGTGATCTCA TCTCACTGCA ACCTCCACCT CCGGGTTCAA GT - #GATTCTCC72960- CGCCTCAGCC TCCCAAGCAG CTGGGATTAC AGGCAAGCGC CACCATGCCC AG - #CTAATTTT73020- GTATTTTTAG TAGAGACGGG GTGATCTGCC CTCCTTGGCC TCCCAAAGTG CT - #GGGATTAC73080- AGGCGTGAGC CACTGCGCCC GTTAGCTGTT TTGTTTTGAA ATCAACTTTG AA - #AAATGTTT73140- TGATATCTCA TCATGTCCCC AATGCCATTT GTAATGGTCA CACAGCATTC TG - #TTGTATGA73200- TGTACCATGC TTTATCTAAC CTGTGTCCTA TTTTTGGATA GTTCGAATTT TC - #CTATTTCT73260- TTTCACTATT AGAAGCAAGG CTGCAATGGA CATCCTTTTA AATACTTTTT AA - #AAACAAAA73320- ACCTTGGTAC AAGTACCTGT ATATAGACTT GCAGGGTCAA AACTTCCCAT TT - #GATGGCTA73380- TTGATATGTA CTAACAAATT GTCCTCCAGA AAGTGGTCTT TTCCTCACCC TC - #ATCAGTTC73440- TTGGTGTTAC CACCTTTTTG CATTTTGCCA AGCTGATAGG TAAAAAAGTG TC - #TCTTACTA73500- TTGTATGTAT TGAATTAAAT TTATTTATTT ATTTATTTAG ACAGGGTCTG GT - #TCTGTCCC73560- CCAGGTAGGA GTGCAGTGGT GCAATCATAG CTCACTGCAG GCTTCAACTC CT - #GGGCTCCA73620- GCAATCCTCC TGCCTCAGCT TCCTAAGTAG CTGGGACTAT AGGTGGGCCC AG - #CTAATTAA73680- ATTTTTTTTT TTTTTTTTTT TTTAAGATAC AAGGTCTCAC TACTTCGCCC AA - #GCTGGTCT73740- TGAACTCCTG AGCTCAAGAC ATCCTCCCAC CTCAGCCTCC TGAGTTGCTG GG - #ATTACAGG73800- CAGGAGCCAC TGTGCCTGCT TATTATATAT TTCAAAATAA CGAAAAGAGT GG - #AATTGCAA73860- GTTCCTCACA CAAAGAAATG ACAAATGCTT GAGATAATGA TTATCATAAT TA - #TCCTGATT73920- TGATCACTAC AACTTGTATG CTTATATCAA AATATCACAT ATTTATATTT TT - #AAAAATTA73980- TATTTATATT TATGTGATAT TTTGATATAT TTTGTAATGA TCATTTTACA TA - #TGAACATA74040- TTTATACATA TATACAAACC AAATAAACCA TACATATTTA TACATATGCA CC - #TATGTACA74100- AACCAAAGAA ATTGGGATAT AGCTATCCCA GTTCTATTAA AAAATTGAGA TT - #TTTTTCTT74160- CTCTATTGAT ATTTCCTACT TTTTTTTTGT TTTGAAAAAT AATTTATCCT TG - #AGTCAGTT74220- GTGATGATTT ATACCTGTAT AGAGATTACT AGTTTGATCA AAATCATTTC AT - #TTATTGTT74280- AAAAATTGTA TAATGATATT ATCTCCTAAC TGAAAATTTT CCTTTATCTC TG - #TGATTATA74340- TTCCATTTCT CATTCATCAT ATTTTCATTT CATTCCAGTT TTCCTTGGTT AG - #ACTTTCCT74400- ATGATTTGTG TCTTTTACTG TTCTTTTCAA AGAACAGCCT TGGTATTTAT TT - #ATCAATTC74460- TATTTCTTTT TAATTTCACA ATTAATTGTT TTCTGTTTTT ACCATGACTA AT - #TCCCACCA74520- CTGCTTTCAT AGATTAATTT TGTGTTCTTT TTCTAATTTC TTCAATTAAT TT - #ATTTTCAT74580- TTTTTAAAAA CTTAATAATA AAAGTTCTTA AAGTCCTAAA TCTTTTCCTG AG - #TACTGTGG74640- GATTCTTTCC ATGTGCTTCT GCATGTAGTA TGACTATTGC AATTGGTATA GA - #TGGTATTA74700- CAGTTCTTAC TCCTTCTTAC ATCCAGGGAT TACTAAGGAG ACTGATTTTA AA - #TTTGCAAG74760- AAGTTTGACT TCTAAAAGTG CCAGGCTCCT TTTTGATGTC AAGTCTCACC TA - #TTTCTTCT74820- GTTTTTCTCT AGTAACTGAG CTCAGGTTTT GTTGAAGGCA GCAAACTACT GG - #CTAAAACT74880- GCTCAATGTT TTCCAGCTAA AATTGCTCAA GTATTTCCTG CAGCTAGTTA GG - #GCAAGTTA74940- CCTGGCTCTG TCTAGAGAGA TGGAGGTGCA GGTCCTTGGA GACAGAGTAC CC - #TCTGAACA75000- AAAAGGCAAA GACTTACCAG CAGAAAACCC ATTTGCCTTT TCCCTTTCCT CC - #TCACTGAC75060- ATGCAAGGGT TATGTCTGGA GGTACGAGAA AAGGAAAGCA TAAGGATAAA AT - #CTAACAGG75120- CTAAGAATGA CAGGGCAGAA AGATAGAAAG GATCTGTGTC CCCGATGGCA TC - #GTTGTACC75180- AGCAAGACTG ATGATCATGA TGTAAGTCAA ATGAATGCCC AGCTGCTGCT GG - #CTGTGTTT75240- TTTGTTATTT GCGGCTGAAT GCATTGCTAA TGTAAACATT ACCTTGCAGC CA - #GAGAATAC75300- GGCTTGCCAA AAGTCTAGTT TTGTATGTTA ATCATGATAC ACCAGCCAGA CA - #GAGTGGCC75360- CTCAGCTGTA ATCCCAGCAC TTGGGGAGGC CAAGGCAGGC GGATCACTTG AG - #GTTAGGAG75420- TTCGAGACCA GCCTGACCAA CATGACAAAC CCCCGTCTCT ACTAAAAATG CA - #AAAATTAG75480- CTGGGCATGG TGGCTCCTGC CTGTAGTTCC AGCTACACGG GAGGCTGAGG CA - #GGAGAATC75540- GCCTGAATGC AGGAGGAGGA GGTTGCAGTG AGCCAAGATG GTGCCATTGC AC - #TCCAGCCT75600- GGGCGACAGA GTGAGACTCT GTCTCAAAAA ATAAAAATAA TAATAATAAT GA - #TATGCCAA75660- CTGCTATAGC ACCTAGACTG CAAAATGTAC ATCACAACAG TCCGATTCTC TG - #TTCTCTTT75720- GTTCAGGGGT AAGCATGGAG CTTAATTTTG ATCTATGAGT CAACGTGGGA AG - #TCCGTTAG75780- GTTAGAAGTG CTTCTGGTCA AGGTTTCTTT GCTTCTAAAA GAGGAATGTG AG - #GAAAAAGT75840- CCCTGTCTTG GTGTGGATTT TGGTGTGGGG GGATGTATAT AAAGCCTGTA GC - #TATTGAAG75900- CCATCTGGCA AACTTGAAGG GAGCAGCTGA CTCTGAGCTG GTAGAATATA GA - #AATGGAAA75960- GGATTTAGAT CTTGATGTGG TTGAGAGGCT GCCCTCCCTT GGGACTTCTT TT - #TTGTGTGT76020- GAGTTAACAA GTTTTCCTTA TTGTTAAGTT GCTTTAGTGG GTTTGCTATT AC - #TTGTAGTC76080- AAAACATTTA TTATGGCATC ATCTACTTTA TTCTATCCTT CTGCTTTCCT TA - #TTACAAGT76140- ATATTTACAA GCTCATTGTC ATTCATGTCA TCATTTTAAT CAGCACCAAC AA - #CAGCATCA76200- CCAGTAACAT TTATTGAGTG TTTTTAAGTG CCAGGCCCTG TTGTTGTCAT TT - #AAATCTTA76260- CACCAATCCC TACTGCTCAG ATACTATTCT TTTTAAAAAT TATTTTTTTT TT - #AGGCACAG76320- GATCTTGCTC TGTTGCCCAG GCTGGAGTGC AGTGGCATAA TCATAGCTCA CT - #GCAGCCTC76380- AAACTCCTGG GCTCCAGTGA TCTTCCTGCT TCAGTTTCCC AAAGTGCTGG GA - #TTACAGGT76440- GTGACCACTA CCCCCTGTCC TATTATTATT GATTCAGATT TACAGATGAG GA - #AAATAAGG76500- CTTAGGAAGG CTACATAATT TCCTAGATTG CTTATTTAGT AAGCGGCAGA GC - #CAGGATTC76560- AAACCCAGAC CTGAGGGACT CCTAGACTAG TCCATGCCAC TGTGATATGG CC - #TTTCACAT76620- CTCTTCTTTC ATCCGTCATC ATGATATCTT TCTCCTCTGA GTTCTGGGGA AG - #TTTCTCAA76680- GTTGGACTGC CAATTTTCTG CAGGATTTTC CTGTGATATA TAACTCCTTC AT - #TTACTGCT76740- TCCATTTTAT TTCATATCAC CTACAATTTC CCTTATGTCT AAAACCAATT GC - #TCCTATAT76800- CTAAGATGCA ACGTCCTTCT GAATTATAGT GTTAATGCAA TAGGGTATTT TG - #AAGGTTTC76860- TGTATGTTTT CTGTAGAAAA GTTATCTCAA AGGGGGATAT ATACTTCCAT TT - #CCCAGTGG76920- TCTACTTCTT TTAAGCCACA AATAGGGCAC TTTCTCTTGT TAGTTTAATC CT - #ACGGGTAT76980- ATAATTTTCA GTATTTCTAG TGTTAGAATT TGAGATTCAG AGAACTATGA GT - #CTCTGTTT77040- TAATCTTTCA GTCCTAGGAA AAGGAGAAAT AGGGCTGCCT ATCTTTTCTG TG - #GTTTTATT77100- TTGCCATTTA ATTTCTAATT GACTGTGAGA TGTATCAAGA GATCTGTAGC TC - #AAGGCAGT77160- TGAATGTCCC AGAGCTTCAC AGCTGAGCCA AGTGACTTCT TTTCCATGTT TA - #TTGTGGCA77220- GCCAAGGTCA GCAGATGCCA TGCCTCTTGC TCTGAGTGCC TGGACCACCC CC - #ATTAAGAG77280- CCTCCCACAG CAACAACTCC ACTTGACCCA CGATAAGTGA GGTTGGCACT GT - #GTCTCTCT77340- CTTTGTACAT TTTGTTTTCT AAGTTGCTTG TAGGGCCAAG CTTTGAGTCC TT - #GTTACCAT77400- CAGCTTAAGC TCCGGCCTCT CTGAATTGGA GGATTTTGTT TGTGTTTGAT TA - #GAGCCTGT77460- TGGCAGAAGC AAGTGCCAAA GTCAGACATA AAACAGAAAA CTCTAATGTG GT - #GTCAAGTC77520- TTTTCCAGAT GTTACTGATC CTCTTTCTTT TCCTTCTTTT TTTTTTCTTT TT - #TGTTATTT77580- TTGATCCCCT TCCTTTTTGC TTCCCTTAGG TTGACCTTTG CTGTCCTACG GG - #CAGTACAA77640- AGATTGGGTC TTTCTGTCTC TGCCTCTCCT GCCCTCGGAC TCCTACCATG GG - #TCTTTTCT77700- TTTTTTATAG AGATAGGGGT CTCACTTTGT TTATCGTGTT TTTTTTTTTG TT - #TGTTTTTT77760- GAGGTGGAGT CTTACTCTGT CACCAGGCTG CAGTGCAGTG GCGTGATCTT GG - #CTCACTGC77820- AACCTCCGCC TCCTGGGTTC AAGCGATTCT CCTGCCTCGG CCTCCTGAGT AG - #CTGGGACT77880- ACAGGTGTGT GCCACTATGC CCAGTTAATT GTTGTATTTT TACTAGAGAC AA - #GGTTTCAC77940- CATGTTGGCC AGGATGGTCT CAATCTCTTG ACCTTGTGAT CCACCCGCCT CA - #GCTTCCCA78000- AAGTTCTGGG ATTACAGGTG TGAGCCACAG CGCTCAGCCT GAACTTTTAC TT - #TTAAGACA78060- ATTGTAGATT CAAATCCTGT GTCCTCTCTT ACACAGTTTC CTCCAATGGG GG - #CATTTTAC78120- AAATATAATA ACCAGGATAT TGACATTGAT ACATTTGATA CAGTCAAGTT AC - #ATTTTCAT78180- CACCACAAAG ATCCTGGTGT TACTCTTTTA TAGCCATACC TGCCTCCTTC TC - #CCCTCCCC78240- CATCCCTCAC GCCGGCAACC ACTAATCTGT TCTCCATTTC TACAATTTTG TC - #GTTTCAAA78300- AATGTTATGT AAACAGAATC ATACAGTTTC TCATCTTTAA GATTCGTTCT TT - #CCTGTTTT78360- TTTTTTCTTT TTTTTCTTTT CTTTGTTTTT TTGAGATGGA GTCTCACTGT GC - #CACCCAGG78420- CTGGAGTGCA CTGGTGTGAT CTCGGCTCAC TGCAACCTCC GCCTCCAAGT TG - #TGGGTTGA78480- AGCGATTCTC CTGCCTCAGC CTCCCAAGTA GCTGGGATTA CAGGTGCCTG CC - #ACCACGCT78540- CGGCTAATTT TTTTTTTGTA TTTTTAGTAC AGACAAGGTT TCACCATGTT GG - #CCAAGCTG78600- GTCTCGAGCT CCTGACCTCA GGTGATCTGC CTCGGCCTCC CAACTTGCTG GG - #ATTACAGG78660- CATGAGCCAC CGCACCCGGC TGAGATTGGC TCTTTCACTC AGCATAATTC CC - #TGGAGACT78720- TCATCCAAGT TGTTGCATGT ATCAATAGCT TGTTTCTTTT CATTGCCACC TA - #GTTTTCAA78780- TGGTATGAAT GCCGCATTGC TTGTTTCATC AGTCACCTGG TGGAAAACAT CA - #GGGTTGTT78840- CCCAGTTTTT AACTATTATG AATAAAGCTG CTATGAACAT TTGTGTACAG GT - #TTTTGTGT78900- GAACATATTA TCATTTCTCT GAGATGAATC AATGCCAAAG NAATGCAATG GT - #ATGTTTAG78960- TTTTATAAGA AACTGCCAAA CTGTTTTCCA GAGTGGCTAT ATGANTTTTG TA - #TTCCTACT79020- AGCAGTGTAT GAATAATCTA GTTTCTTTAC ATCCTCACCA GCATTTCATG TT - #CTCAGTAT79080- TTTTTTTATT TTAGTTAATC CGATATGTAT GTAGTGCAAT ATCACTGTGG TC - #TTAATTTT79140- TAGTTCACCA GTGCTAATGA TGTTGAATAT CTTTCATGTA CTTATTTGCC AT - #CTGTATAT79200- CCACTTGGTG AAATACTTCA TGTCTTTAAA GAAGACCCAG GATTTCTAAA AA - #ACTGTTGA79260- GTTTTGAGAA TTTAAGAAAT ATATTCTAGA TACTGGTACT TTGTTGGATA CA - #TGGTTTGT79320- AAATATGTTC TCCTAGTTTG TAGCTTGTCT TTTCATATGT GTTAAAGCTT AT - #CTCCCATT79380- TTATTATTTG TTTTCTGTTT ACTTTGTTTC TTATTCCTCT ATTCTCACTT TG - #GGTGGATT79440- ATTTAAATAT TTTTTAAGGT TTCATCTTGA TTTATTTGTA GCATTTTGGG TA - #CATCTCTT79500- TGTACACTTT TCTTAGTGGT TGCCCTGGGT GTTACCATAT ACATATGTCA AG - #AGTCACAT79560- TCTGCTGGTG TCAGTGTTTT TCCAGTTGAA GGCAAGTGTG GAAAACTTAC CT - #CCATTTAG79620- ATTCCTTTAC TCTTCCCATT TTTAAAACAT GTGTCTCAAG TATTCCCTCT AC - #ATTCATTG79680- ATCAGCACAC TAGAGAGTGT TATTTTGGCT TTAACCTTCA AATATAATTT AA - #GACACTCA79740- GGAGAATAGG ATCATCTATT ATGTTTACCC CTGTCTTTGC CTGTTTTGAT GT - #TCTTCATT79800- CTTTTCTAAA GTTTCAAGCA TTCTTCTGTT ATCATTTCCT TTCTGTTTAA AG - #AACTTCCT79860- TTAGTCGTTC TTTAAGGACA GATTTACTAG CAACAGATTC TCAGTTTTCC TT - #CATCTGAG79920- AATGTCTTTA TTTCCCCTGC ATTCCTGAAG GATATTTTCA CCTGATATGG AA - #TTTGTGAG79980- TGATAGTTCT TTTTCCTCTA AGCACTTGAA AAATGTTATG CCACTTTCTG CT - #GTCTTTTA80040- TGGTTTCCGA AGAGAAATCC ACTTTCATTC AAACTGTCAT TTCCCTGTAA GT - #AATGGATG80100- TTTTCTGTCT AGTTGCCTTC AAGACTTTGT CTTTAGTTTT TACAAGTTTA AT - #TATGATAT80160- GTCTTGGTGT GAATTTCTTT GAGTTTATCC TGCTTATGAT AGTTCACACA GC - #TTTTTGAA80220- ACTGTAGGTT TATGTCTTCC ACCAAATTTT ACTGAATTTC TTCAGTTCTA TG - #GTCTTGCT80280- CCTCTTCCTG AAGTATTCCA ATGATACCGT GTTCTCTTTT GTTACGGTCC CA - #CTGGTCTT80340- TGAGACTCTC TGTTCATTTT ATTTCGGTCT TTCTTTTCTC TGTTGTTCAG AT - #TGGGTAAA80400- TTCCATTGAT CTACCTTCAA GCCCACTGAT TCTGTCCTCT ATCATCTCTA TT - #ATTGAGCC80460- CAACCACACA GTTTTAATTT TGATTATTGT ATTTCTCAGT TCTATAATTT CC - #ATTTGGTT80520- ATTTTTCAAT GACTTCCATT TTTGCTGAAA TTTTCACTTG TTTCAAGAGA AT - #TTGTAATT80580- ACTTGTTGAA GCACTTTTAT AATATCTGTT TAAAATACTT GTCATATAAT TC - #CAGTAACT80640- AATTCATCTT GGTGTTGACA TCTGTTTATT GCTCACTTAA AAATAAAAAA TA - #AAAAACAC80700- CTAGACTTTA TTTTTTATAG CAGTTTAAGG TTCACAGCAA AATTGAGAAG AA - #AGTAAAGA80760- GTGTGCCCAG AAAAATAGTA CCCCTATGCA GAACCTCCCT GATATTGTTT GG - #CTGTGTCC80820- CCCACCAAAT CTCATCTTGA ATGGTAGCTC CCACAATTCC CACGTGTTGT GG - #GAGGGATC80880- CAGTGGGAGG TAATTGGATA ATGGGGGCGA ATCTTTCCCA TGCTGTTCTC AT - #GATAGTGA80940- ATAAGTCTCA TGAGATCTGA TGGTTTTATA AAGAGGGGTT CCCCTGCACA AG - #TCCTCTCT81000- TGCCTGGCGC CAGGTAAGAA GTCCCTTTGC TCTTCCTTCA TCTTCCATTA TG - #ATTGCGAG81060- GTCTCCCCAG CCATGTGGAA CTGTAAGTCC ATTAAACCTC CTTTTCTGTA TA - #AAGTACCC81120- AGTCTCAGGT ATGTCTTTAT TAGCAGTGTG AGAATGGACT AATACACTCC CT - #ATCAACAT81180- CCCCTACCAG ATTGGTATGT TTGTTGTAAT CGATGAACCT ATGTCAACAC AG - #CGTTATTT81240- CCCAAGCTCC ATAGCTTATA TGAGGATTCG CTCTTGGTGT TTACATTCTG TG - #AGTATTGA81300- CAAATGTATG ATGAAATGTA TTGACCATTA TAGTGTCATA CAGAATACAG GA - #TAGTTTCA81360- CTGTCTTAAA AAATCTTCTG TGCTCCCCTT ATTCATCCCT TCCTTCTGTG TA - #AGCCCTGG81420- CAACCACCGA GCTTTTCACT GCCTCCATTG TTTTGCTTTT TCCAGGATGT CA - #TAGAGATG81480- GACTCATACA GTAGGTAGCC TTTTGAAATT GACTTCTTTC ACTTAGTAAT AT - #GATTCCTC81540- CATGTCTTTT CATGGCTTGA TAGCTAATTT CTTTATAGTG CTGAGTAGTA TT - #CCATTCAC81600- TTATAATTCC TTGAATTCAT TGTTTGGAAT ATTTTGCAGA TGATATGCTA TT - #CCCTAACT81660- TTATGCATCT TCACTCACAG GATTGTTTTT TTCTCACCAA TGCTTATTTA TA - #TAAAAGCC81720- ATATCAACAA AATTTTACAC ATCAAAAATT TTCAGACTTC TGGTTGCTCC AA - #AGAAGGAA81780- TGACCCCATT CTTCTCAGGT CCTCTTCCTC ATGACTAAAA AACTCTGAAC AA - #AGCACAGA81840- AAGTTGCGGA AGGCTCTGAA AGGTGAAAGG AGGTGGACTG CCTAGGGACC TC - #AGGACTTG81900- GAAAACAACT CAGTGGGGAA TTCCGTGGAT TTCCTTATCA CCTCCCTTAT AT - #CCTGGACA81960- CGGAGCTGCA GAAGACTCCA ACCTACAGTC ACCAATGCGC ATAGAAGAAA AA - #AGCTCCAA82020- GAAAAGCCTT TTCCTCCTGG CCAGATGACT GGACAAGGGT GGCCTGACAA CA - #GAAAACCC82080- ACAACAAGGA ATTACAGGTA ACTCCAGAGA GGATCAGCTT GAGTGGTTAA AA - #CAAGTACA82140- TGGAAAACAA AAAGAAGCAT TTTTCTTTTT TTGTAAAAGA GCTTGTACTG TA - #ATAACTTT82200- GATTTTGTTT TTTGTTTTTT GTTTTTTGTT TTTTTTTTGA GACTGAGTCT CA - #CTCTATTG82260- CCCAGGCTAG AGTGCTGTGG CGCAATCTTG GCTTACTGCA ACTTTTGCCT CC - #TGGGTTCA82320- AGTGATTCTC ATGTCTCAGC TTCCTGAGTA GTTGGGATTA CAGGCATGCA CC - #ACCACACC82380- AACTAATTTT TGTATTTTTA GTAGAGATGG GGTTTGACCA TGTTGGCCAG AC - #TGGTCTTG82440- AACTCCTGAC CTCAAATGAT CTGCCCACCT TGGCCTCCCA AAGTGCTGAG AT - #TACAAGCC82500- TGAGCCACCG CACCTGGCCA ACTTGGACTT ATTTTTATAA TAAGTAGATA TT - #GTTCACTG82560- TAGATATTGA ATCAATTTTT ATTTAATCTT GATTTTTTTT CTTGAGCTGC AT - #TAGAAATT82620- CATTACAATA TTTCAATTTA TAAATCTTAT TAAAAATTAC TACTACCTAG AT - #CTCATTGT82680- TTTCTTTTTT CTTTTTTGAG ACATGGTCTT GCTCTGTCAA GCAGGAGTGC AG - #TGGGACAA82740- TCATAACTCA CTGTAGCCTC CAACTCCTGG GCTCAAACGA TCCTGCTACC TC - #AGCCTCCT82800- GAGTAGGTGG GACTATAGGT GCACGCCACC CATGTGTGGC TAATTTTCTT TA - #TTTTTTTT82860- TGTAGAGACA AGGTCTCACT GTGTTGCCCA AGCTGGTCTT GAATTCCTGG CT - #TCAATCAA82920- TCCTCCCGCC TCAGCCTCCC AAGGTGTTGG GATTTCAGAC GTGAGCCACT GC - #ACACCTGG82980- CCCCATTTTT TTTCCTTGAA TAAAGTGTAC TGGTAAATTT TAGGCTCATG AG - #GGTATATA83040- TGCATTATTT TCTTCAAATC AAGCCTGAAT CAAAGAAACT TCTGCTTTAG TT - #TTAGTGAT83100- ATTTGTCCCA AATGTTTAAA GACTGTATCA TTCTGATGAA TTGGATATTC CC - #ATTGAGAG83160- ATATTCAATA GGCCTTGATT GAAATGTTCT TCATTTTCTT TTTAAATTCT AT - #TTACAGTA83220- GTCTGCATGT GTTAGAACTT TCAGAAAGGG AGAGATTTCT GTCTGGGCTG TC - #CCCACCAG83280- CCAGAAGGGT CTGAGAGGCA CTGACTTGCC CTGGGGTGAT ATTTCTGCAG GA - #CTTTGCTC83340- CTCTGTAGGA AGACAGCCTA GAACAGAGGT GAAGGATGCC TCGGGCCTGC CT - #AGACCAAC83400- AGCCATTCCC TGGTGATGCT GTAGTGTGAA GACCCTTGTC TTTCCCAACA CC - #TGTGATAG83460- CTTTCAAATT ATTCTTTTCA GACAAACTTT ATGCCTGTTT CTTTATCTCT AT - #TTTGCATC83520- CTAACAGAAA AAGCCAATCA CCTAGAAGGG AAAGTCAGAC TGGTCCCTGC TG - #CTTTCCCC83580- ACATCTCCAC TGCCCCCAAT ATTGAATGCC GTGACAATGG AATGAAATTC CA - #ATGTCCAT83640- GAAATTCTGA GGGGAGACAT TTTGACTCAA GATTATATAC TCAGTGAAGA TG - #TCCTTTAT83700- TTATTTATTA AATTAATTTT TTTTGAGATG GAGTCTCTCT CTGTCTCCCA GT - #TTGGAGTG83760- CAGTGGTGCG ATCTCGGCTC ACTGCAACCT CTGCCTCCTG GGTTAAAGTG AT - #TCTCCTGC83820- TGCAGCCTCC TGAATAGCTG GGACTATAGG TACTCACCAC CACACCTAGC TA - #ATTTTTTT83880- TTTTTTTTTT TTTTTTTTGG TAAAGATGGG GTTTCACCAT GTTGGCCCGT CT - #GGTCTTGA83940- ACTCCAGACC TCAGGTGATC TGCCCGCTTT GGCCTCCCAA AGTGCTGGGA TT - #ACAGGCGT84000- GAGCCACCTT GTCTGGCCAA AGACGTCCTT TAACTAAAGA CTTCTGGTGT AT - #GTTACCTT84060- AAAAATATAA ATATAAAAGC ATGAAGAAAA TACAACCTCC ATGGAATTTT TT - #TGCCAATG84120- AATCTAGAAA AATAAGAATT GATTCAAAAT AATGAATAGG GAAGCTGTAA TA - #AAATGACT84180- TGAGGGTTCA TTGAGTCCAT TTAAATATAT ATCTCTTACT AAAATCACTA AG - #GGTCATAA84240- TTAGACAATG AAGTAAGTGC CATAAATCTA AACAATGTAA ATAACAATAT AT - #CTAAAAAA84300- AAAAAACTAA GGAGTTTGGA GAGAGGATAC GGGAGGATGT GTTCTTTCAT AG - #TAGGGAAT84360- TAGTTAATAT TCTTTAAAAT GGAAACATGT AAGAAAAAAG ACCCTAATGA CT - #GAAAACTA84420- AGTTTTCCTC AATCTTTTTT TCATATCCTT TGAAGGCTAT TTTAAGAAAT AA - #TATCTAAA84480- GAACATCGAT TTGATGTTCA CAATTCCAGT TGATTTTCCT TCTGTGAAAT TC - #AAATGAAA84540- TTAAATAAAT ATGTTTTGTT AAAAATGGTG TCATCCCATT TAAGTAAATG TC - #CTTTCTTT84600- TACCTATTTA TCCATCTATA ATCTGTATCT ATTCATCCAT CAATGGATAC AT - #GTGCACAG84660- ATAAATGGCC CCTTTGGTGA AGGGCTGAGA GGGTATTGTT TTCTAACCCC AA - #CCTGTGAC84720- GGCTTCCATG AGGCCAATGG AATCATTTTG AAATGTGTTT ACCACAGCAG GG - #AGACACAG84780- AAGACTGGGG TCTCACACCT GTGTGGGAAC TCCAGAGGGT GAGAAAAGGG CC - #AATGAACT84840- GCTCCGGTGA CACAGCAGGG AGGGTGGCTG CCGTGCTGGG TGCGGCCTGC CT - #TCCTAGAG84900- AATGTCAGGG AAAGGGATGT GGGGTCATTT CCTGTGGACA CATTTAAGCC AA - #GTAGGGGA84960- GAGGTCTGGT ATGGGGTCCT CTTGGGGCCT GTTGGACAGG GTTGACCAGC AG - #AGAGAGGA85020- TGCCCAAGGA TTGAAGGAGG AGTGGGTAAG AGGTTCTCTA GGTCATGGGA AC - #TTCTGAAT85080- TTCCCATGGA AAGCACCACC ATAATCTGTG TGCAATGAAC AGCCAGACCC AC - #GTGGGAAT85140- TCTAGGCCAG CAAGAATCCC TTACTTGCTC ACTGGCTGCC ACGTGGCTCT GA - #CCATGGAG85200- AGGTCTGGAA CTGTAGCTTC CCAGTGGGGG AGAAGTAGGC TGGGAGAGAG AA - #GGGGACAG85260- AGGAACCACA CCCTCCTTCC CCACCTCCAA ACAGAAGCCA GTAAAAATTG AG - #GGATGGAG85320- AAAAATATAA GGCTAAATTA AGTTTTGGAA CTTTGGCATG ATCAAGGCTC AC - #TGCAGCCT85380- CAACCTCCTG GGCTCAAACA ATCCTCCCTT CTCAGCCTCC TGAGTAGCTG GG - #ACTACAGG85440- CACATACAAC CATGCTCACC TTTTTTTTTT TTTTTTTTTT GTAGAGATGG GG - #TATTGCTA85500- TGTTGCTCAG GGCTGGTCTC AAACTCCTGG GCTCAAGCAA TTCTCCTGCC TC - #AGCCTCCA85560- AAAGTGCTGG GATTACAGGT GTAAGCCATT GGCCCTGCCA AGTTTAAGAA CT - #TTTACAGT85620- TATAAGAGAC TAGATATTTT AATTATTATT ATTATTTTTT AGACAGAGTC TT - #ACTCCGTA85680- TCCAGGCTGG AGTGCGGTGG CACAATCTTG GCTCACTGTA ACCTCCACCT TC - #TAGGTTTA85740- AGCGATTCTC CTGTCTCGGC CTCCTGAGTA GCCAGAATTA GTAGAGACGG GG - #ATTCGCCA85800- TGTTGATCAG GCTGGTCTCG AACTCCTGAC CTCAAGTAAT CCACCTGCCT TA - #GCCTCCCA85860- AAGTGCTGGG ATTACAGTAG ATATTTTAAT TTTTTTGCAT GGAGGCTATT TT - #TACTACTA85920- AAAGTGAATG AAGTATATTT TGTATCTTCC AGGAGTTTGG AAAGTCAAGT CT - #ATTTGCAC85980- CCAGCCACGT GCCTGCCATG GTGCCCGCGG CCTCTCAATT TTTGACCTTT GT - #TTATGCTG86040- CTCTGTCTAC CCAGAATGCT CTCCATCGAG GGAAACCTAC TCTCTCTTCA AG - #GCCAAATT86100- CCAGCATCAC CTCCGCCATG AAGCCTTCAT AGATCTACTC AANGTAGAAA CT - #TCTTAACC86160- CCTCTAAACT GTCTTAGCAT CTTGGTTGTA GTATTGGTTT AGAATAGCAC AA - #ATTCTACC86220- CAAAATCTCA CTAAGTCTAT TCTAAGCAAA TCTTGGATAA TTTGCTAACA CT - #AAAATTAA86280- ACCTGTTCTC TTTTGGTTTT TTGCTAACAA TGAAACAAAC TTGGTCTTAC TC - #TTTTGCTC86340- AAGCTGGAGT ACAGTGGTGT AATCATGTCT CACTGCAGCC AGGAATTCCC GG - #ACTCAAGG86400- GATCGTCCTA CCTCAGCCTC CTGAGTAGCC GGGACTACAG GTGTGCATAA CC - #GTGCCTGG86460- CCAGTTTTAA AATTTTTATT TAGGGACAGA GTTTTGCTAT GTTGTCCAGG CT - #GGTCTTGA86520- ACTATTGACC TCAAGTGATC CTCCCACCTT GGCCTTTCAA AGTGCTGGGA TT - #AGAGGTGT86580- GAGCTGCCAC ACCCAGCCCC GTTCTCTCTT TTGCATCTAT ATTAGTCTCT GT - #GCTCTTGG86640- GAAAAGTGGA CCAATATCAT TTCAAAACTT GATGAAAAAG AAAATTAAAA TC - #TCATCCTC86700- GGGAACTGAA ATCACAAACC ACCCAGCAAG GTCCACACCT CTAGGAGACT GG - #CATTTAGA86760- AGACAGGACC ACAGTTGAAG CAACGGTTCT TTCTTTACCC TCCCTGCCTG TG - #ACAGACTG86820- CATGTGCTGA TTATCCCTGC GTTTTCTGCA GAGCTTGCCT TCCTGGTGAT AC - #AGTACTTT86880- ATTTTATTCT GAGGGCCCCT TCCTGCCAGG GGATATCTGT CAGGGGATAC AT - #AAAACTGC86940- ACAAAATGGA ACAAGTTATA GGTCATATAA AATTTCAGGA CATTGTTGAG AA - #GGAGAAGT87000- TGCTAAATTG GAGACACCAT GATGTGAAAT CCCAGGGTCC CAGAATATTG AT - #GGAACTAG87060- TATGTTTTTC TTATGTAATA TTTTATGGTG TCTGGGAAAT GGAGTTGCCT AA - #GTGAACTC87120- ATTTTTTATG TCTAGGGGAA TAGCAACATA ACTATCATCT AACACTAAAT AA - #AGAGGAGC87180- AAAATGTGCT ACATTTAGAA AGTGATGGTA TTATCCCCAG CTGAGGCAGA CT - #TAGTGATG87240- GTGTTAGAAA TAAAGTATGG TAGGAGGCTG AGGCAGGTGG ATTGCATGAG CT - #CAGGAGTT87300# 87350GCAACA TGGCGGAAAC CCCATCTCTA CAAAAATCCA- (2) INFORMATION FOR SEQ ID NO:80:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:80:# 25 CTCA GTAGA- (2) INFORMATION FOR SEQ ID NO:81:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81:- AGATGTACTT TGGCCATTCC AG 22- (2) INFORMATION FOR SEQ ID NO:82:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82:# 22ATC TC- (2) INFORMATION FOR SEQ ID NO:83:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83:# 23GTTC TTC- (2) INFORMATION FOR SEQ ID NO:84:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:84:# 22AGG TG- (2) INFORMATION FOR SEQ ID NO:85:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:85:# 23AATC ATC- (2) INFORMATION FOR SEQ ID NO:86:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86:# 24AATT TCGG- (2) INFORMATION FOR SEQ ID NO:87:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87:# 22TAT GC- (2) INFORMATION FOR SEQ ID NO:88:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88:# 22CCT GG- (2) INFORMATION FOR SEQ ID NO:89:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 20 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89:# 20 CTGC- (2) INFORMATION FOR SEQ ID NO:90:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:90:# 22GCA GC- (2) INFORMATION FOR SEQ ID NO:91:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:91:# 23AGAA GGG- (2) INFORMATION FOR SEQ ID NO:92:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 20 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92:# 20 ACGC- (2) INFORMATION FOR SEQ ID NO:93:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93:# 23ATCT CCC- (2) INFORMATION FOR SEQ ID NO:94:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94:# 22GTG TC- (2) INFORMATION FOR SEQ ID NO:95:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:95:# 25 AACT GACTC- (2) INFORMATION FOR SEQ ID NO:96:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96:# 26 TTCA GTGAAC- (2) INFORMATION FOR SEQ ID NO:97:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97:# 24TAAA ACTC- (2) INFORMATION FOR SEQ ID NO:98:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 21 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98:#21 TGGC C- (2) INFORMATION FOR SEQ ID NO:99:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99:# 23TTTA GCC- (2) INFORMATION FOR SEQ ID NO:100:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100:# 25 CATT CTGTG- (2) INFORMATION FOR SEQ ID NO:101:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:101:# 26 GGTC AATGTG- (2) INFORMATION FOR SEQ ID NO:102:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102:# 25 AACA TTTCC- (2) INFORMATION FOR SEQ ID NO:103:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103:# 24TCTG CCAC- (2) INFORMATION FOR SEQ ID NO:104:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104:# 24AAGA TGGG- (2) INFORMATION FOR SEQ ID NO:105:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105:# 23TGTT CAG- (2) INFORMATION FOR SEQ ID NO:106:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106:# 25 TTTG ATCCC- (2) INFORMATION FOR SEQ ID NO:107:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107:# 26 TATT CTTCAC- (2) INFORMATION FOR SEQ ID NO:108:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108:# 25 AAGG TCAGC- (2) INFORMATION FOR SEQ ID NO:109:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109:# 23ATGT CCC- (2) INFORMATION FOR SEQ ID NO:110:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:110:# 23TAGG CCC- (2) INFORMATION FOR SEQ ID NO:111:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:111:# 23TGGA TCC- (2) INFORMATION FOR SEQ ID NO:112:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:112:# 22CAC TG- (2) INFORMATION FOR SEQ ID NO:113:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113:# 22ACA GG- (2) INFORMATION FOR SEQ ID NO:114:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:114:# 24TCAA ATGG- (2) INFORMATION FOR SEQ ID NO:115:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115:# 25 TTTG AGAGT- (2) INFORMATION FOR SEQ ID NO:116:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116:# 26 GCAT CAAAGG- (2) INFORMATION FOR SEQ ID NO:117:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117:# 24AAAA GAGG- (2) INFORMATION FOR SEQ ID NO:118:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:118:# 26 AAAG AACAGG- (2) INFORMATION FOR SEQ ID NO:119:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:119:# 23ACCC ACG- (2) INFORMATION FOR SEQ ID NO:120:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:120:# 23GGTT TGG- (2) INFORMATION FOR SEQ ID NO:121:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121:# 25 TAAG ATAGG- (2) INFORMATION FOR SEQ ID NO:122:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:122:# 24TAGA TGAG- (2) INFORMATION FOR SEQ ID NO:123:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123:# 25 CACT CCCCA- (2) INFORMATION FOR SEQ ID NO:124:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:124:# 23AGGA TGG- (2) INFORMATION FOR SEQ ID NO:125:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125:# 26 AAGG AAATCG- (2) INFORMATION FOR SEQ ID NO:126:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:126:# 23CTGA AGC- (2) INFORMATION FOR SEQ ID NO:127:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:127:# 26 AAAG ATCTGG- (2) INFORMATION FOR SEQ ID NO:128:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:128:# 23AGGG ACT- (2) INFORMATION FOR SEQ ID NO:129:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129:# 23AG CCT- (2) INFORMATION FOR SEQ ID NO:130:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:130:# 23GT GGG- (2) INFORMATION FOR SEQ ID NO:131:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:131:# 24TAAC AGCA- (2) INFORMATION FOR SEQ ID NO:132:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132:# 24AAGT CCCA- (2) INFORMATION FOR SEQ ID NO:133:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:133:# 25 CTAA ACACA- (2) INFORMATION FOR SEQ ID NO:134:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134:# 23AAAC TGG- (2) INFORMATION FOR SEQ ID NO:135:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135:# 22TCT GC- (2) INFORMATION FOR SEQ ID NO:136:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136:# 22CTG AG- (2) INFORMATION FOR SEQ ID NO:137:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:137:# 22ATG GG- (2) INFORMATION FOR SEQ ID NO:138:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:138:# 23AAAC TGG- (2) INFORMATION FOR SEQ ID NO:139:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139:# 22TCT GC- (2) INFORMATION FOR SEQ ID NO:140:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:140:# 25 TTGG AAAGG- (2) INFORMATION FOR SEQ ID NO:141:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141:# 25 TGAG AATGG- (2) INFORMATION FOR SEQ ID NO:142:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:142:# 23CTGA CAG- (2) INFORMATION FOR SEQ ID NO:143:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:143:# 25 TGAT TAGGC- (2) INFORMATION FOR SEQ ID NO:144:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144:# 25 ACTC TTAGC- (2) INFORMATION FOR SEQ ID NO:145:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:145:# 24ACAT TCTC- (2) INFORMATION FOR SEQ ID NO:146:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:146:# 22TAT GG- (2) INFORMATION FOR SEQ ID NO:147:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147:# 24TGAA GCTC- (2) INFORMATION FOR SEQ ID NO:148:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148:# 23CTTC TGG- (2) INFORMATION FOR SEQ ID NO:149:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:149:# 23CATC AGC- (2) INFORMATION FOR SEQ ID NO:150:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:150:# 24CCCA AGTC- (2) INFORMATION FOR SEQ ID NO:151:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:151:# 24AACT TGTG- (2) INFORMATION FOR SEQ ID NO:152:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:152:# 25 TTAA CAGTG- (2) INFORMATION FOR SEQ ID NO:153:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:153:# 23CTAC CTG- (2) INFORMATION FOR SEQ ID NO:154:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 24 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:154:# 24ACAT AGAG- (2) INFORMATION FOR SEQ ID NO:155:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:155:# 23AAAG AGG- (2) INFORMATION FOR SEQ ID NO:156:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 21 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156:#21 CCCA G- (2) INFORMATION FOR SEQ ID NO:157:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:157:# 23ATTC AGG- (2) INFORMATION FOR SEQ ID NO:158:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:158:# 22AAC CC- (2) INFORMATION FOR SEQ ID NO:159:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159:# 25 CTTT CTTCC- (2) INFORMATION FOR SEQ ID NO:160:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 26 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160:# 26 AAGA GGCTTG- (2) INFORMATION FOR SEQ ID NO:161:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:161:# 23TCTA CCC- (2) INFORMATION FOR SEQ ID NO:162:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162:# 22ATC CC- (2) INFORMATION FOR SEQ ID NO:163:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163:# 23GTTC ACC- (2) INFORMATION FOR SEQ ID NO:164:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 29 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:164:# 29 TACC CATGAAGAC- (2) INFORMATION FOR SEQ ID NO:165:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:165:# 23TGTT TCC- (2) INFORMATION FOR SEQ ID NO:166:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 25 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:166:# 25 CAAT ATCAC- (2) INFORMATION FOR SEQ ID NO:167:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 22 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:167:# 22GAG AG- (2) INFORMATION FOR SEQ ID NO:168:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 23 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:168:# 23TCTA CCC- (2) INFORMATION FOR SEQ ID NO:169:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 18 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:169:# 18 tc- (2) INFORMATION FOR SEQ ID NO:170:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:170:# 36 TTAA AGAAAGgtat gttgtt- (2) INFORMATION FOR SEQ ID NO:171:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:171:# 36 GTGA TATTAGgtaa gtgatt- (2) INFORMATION FOR SEQ ID NO:172:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:172:# 36 TCCA TGTCAGgttg gtatct- (2) INFORMATION FOR SEQ ID NO:173:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173:# 36 CCAT AAAAAGgtaa aagcaa- (2) INFORMATION FOR SEQ ID NO:174:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:174:# 36 TGAT GCTTATgtac gtgctt- (2) INFORMATION FOR SEQ ID NO:175:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:175:# 36 TTAA ATAAAGgtat gttaag- (2) INFORMATION FOR SEQ ID NO:176:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:176:# 36 AACC ACGGAGgtta aatatt- (2) INFORMATION FOR SEQ ID NO:177:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177:# 36 TACT ACTGAGgtac taaaat- (2) INFORMATION FOR SEQ ID NO:178:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:178:# 36 TCTG CTTAAGggta tgttta- (2) INFORMATION FOR SEQ ID NO:179:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179:# 36 TCTG CTTAAGggta tgttta- (2) INFORMATION FOR SEQ ID NO:180:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:180:# 36 GATG ATAAGGgtaa gcactg- (2) INFORMATION FOR SEQ ID NO:181:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:181:# 36 TGTT TAAACCgtga gtataa- (2) INFORMATION FOR SEQ ID NO:182:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182:# 36 GTGG CAACTGgtaa gttgta- (2) INFORMATION FOR SEQ ID NO:183:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183:# 36 GACA GCTTAAgtaa gtcatg- (2) INFORMATION FOR SEQ ID NO:184:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184:# 36 CAAT TAAATTgtga gtaatt- (2) INFORMATION FOR SEQ ID NO:185:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:185:# 36 ATTG ATATTGgtaa gtgata- (2) INFORMATION FOR SEQ ID NO:186:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:186:# 36 CGTG CCAATGgtaa gctttg- (2) INFORMATION FOR SEQ ID NO:187:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:187:# 36 ATAA AACAAGgtaa ggattt- (2) INFORMATION FOR SEQ ID NO:188:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188:# 36 CTAA ATTCAGgtat gaggat- (2) INFORMATION FOR SEQ ID NO:189:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:189:# 36 ATTT AAATAGgtaa aaaaaa- (2) INFORMATION FOR SEQ ID NO:190:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190:# 36 TCAG GAGACAgtat gtatta- (2) INFORMATION FOR SEQ ID NO:191:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:191:# 36 CTAG GTCCAGgtaa agattt- (2) INFORMATION FOR SEQ ID NO:192:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:192:# 36 TCGA GGATCTgtaa gtatat- (2) INFORMATION FOR SEQ ID NO:193:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:193:# 36 CACG AAAAAGgtaa acagtg- (2) INFORMATION FOR SEQ ID NO:194:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194:# 36 AACT GCCTAGgttc attttt- (2) INFORMATION FOR SEQ ID NO:195:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:195:# 36 AAAG AAGAAGgttt gtttta- (2) INFORMATION FOR SEQ ID NO:196:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:196:# 36 TTAA AAAAAGgtac agagtt- (2) INFORMATION FOR SEQ ID NO:197:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:197:# 36 GGAG ACTCAGgtaa ggcttt- (2) INFORMATION FOR SEQ ID NO:198:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:198:# 36 TTAA AATGAGgtaa actatc- (2) INFORMATION FOR SEQ ID NO:199:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:199:# 36 TAGT GTTCAGgtaa aatact- (2) INFORMATION FOR SEQ ID NO:200:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:200:# 36 CTTG CCTTTGgtaa gtgtga- (2) INFORMATION FOR SEQ ID NO:201:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:201:# 36 ATCA ACTCAGgtga gaggca- (2) INFORMATION FOR SEQ ID NO:202:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 36 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:202:# 36 GTAT ACTGAGgtat taatta- (2) INFORMATION FOR SEQ ID NO:203:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 18 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:203:# 18 TC- (2) INFORMATION FOR SEQ ID NO:204:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 13 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:204:- Phe Pro Gly Ser Glu Glu Ile Cys Ser Ser Se - #r Lys Arg# 10- (2) INFORMATION FOR SEQ ID NO:205:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 4792 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 145..4347- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:205:- GTATAAAGTT AGTAAATGTG AGGCCTCTCT CGATGCCTGG GTCCTGGGCT TT - #GGTTCTCA 60- GTCCTCCATA AATCATCCTG CTGGAGGAGA AGACCCTTAG ATCTGGCTCT TC - #TCAGGGGC 120- ATTTTAAAGA CAAATGAAAA TAAA ATG GAA ACC ACT TCA C - #TA CAG CGG AAA 171#Leu Gln Arg Lysu Thr Thr Ser# 5 1- TTT CCA GAA TGG ATG TCT ATG CAG AGT CAA AG - #A TGT GCT ACA GAA GAA 219Phe Pro Glu Trp Met Ser Met Gln Ser Gln Ar - #g Cys Ala Thr Glu Glu# 25- AAG GCC TGC GTT CAG AAG AGT GTT CTT GAA GA - #T AAC CTC CCA TTC TTA 267Lys Ala Cys Val Gln Lys Ser Val Leu Glu As - #p Asn Leu Pro Phe Leu# 40- GAA TTC CCT GGA TCC ATT GTT TAC AGT TAT GA - #A GCT AGT GAT TGC TCC 315Glu Phe Pro Gly Ser Ile Val Tyr Ser Tyr Gl - #u Ala Ser Asp Cys Ser# 55- TTC CTG TCT GAA GAC ATT AGC ATG CGT CTG TC - #T GAT GGC GAT GTG GTG 363Phe Leu Ser Glu Asp Ile Ser Met Arg Leu Se - #r Asp Gly Asp Val Val# 70- GGA TTT GAC ATG GAA TGG CCG CCC ATA TAC AA - #G CCA GGG AAA AGA AGC 411Gly Phe Asp Met Glu Trp Pro Pro Ile Tyr Ly - #s Pro Gly Lys Arg Ser# 85- AGA GTC GCA GTG ATC CAG TTG TGT GTG TCT GA - #G AGC AAA TGT TAC TTG 459Arg Val Ala Val Ile Gln Leu Cys Val Ser Gl - #u Ser Lys Cys Tyr Leu#105- TTT CAC ATT TCT TCC ATG TCA GTT TTC CCC CA - #G GGA TTA AAA ATG TTA 507Phe His Ile Ser Ser Met Ser Val Phe Pro Gl - #n Gly Leu Lys Met Leu# 120- CTA GAA AAC AAA TCA ATT AAG AAG GCA GGG GT - #T GGG ATT GAA GGG GAC 555Leu Glu Asn Lys Ser Ile Lys Lys Ala Gly Va - #l Gly Ile Glu Gly Asp# 135- CAG TGG AAA CTT CTG CGT GAT TTT GAC GTC AA - #G TTG GAG AGT TTT GTG 603Gln Trp Lys Leu Leu Arg Asp Phe Asp Val Ly - #s Leu Glu Ser Phe Val# 150- GAG CTG ACG GAT GTT GCC AAT GAA AAG TTG AA - #G TGC GCA GAG ACC TGG 651Glu Leu Thr Asp Val Ala Asn Glu Lys Leu Ly - #s Cys Ala Glu Thr Trp# 165- AGC CTC AAT GGT CTG GTT AAA CAC GTC TTA GG - #G AAA CAA CTT TTG AAA 699Ser Leu Asn Gly Leu Val Lys His Val Leu Gl - #y Lys Gln Leu Leu Lys170 1 - #75 1 - #80 1 -#85- GAC AAG TCC ATC CGC TGC AGC AAT TGG AGT AA - #T TTC CCC CTC ACT GAG 747Asp Lys Ser Ile Arg Cys Ser Asn Trp Ser As - #n Phe Pro Leu Thr Glu# 200- GAC CAG AAA CTG TAT GCA GCC ACT GAT GCT TA - #T GCT GGT CTT ATC ATC 795Asp Gln Lys Leu Tyr Ala Ala Thr Asp Ala Ty - #r Ala Gly Leu Ile Ile# 215- TAT CAA AAA TTA GGA AAT TTG GGT GAT ACT GC - #G CAA GTG TTT GCT CTA 843Tyr Gln Lys Leu Gly Asn Leu Gly Asp Thr Al - #a Gln Val Phe Ala Leu# 230- AAT AAA GCA GAG GAA AAC CTA CCT CTG GAG AT - #G AAG AAA CAG TTG AAT 891Asn Lys Ala Glu Glu Asn Leu Pro Leu Glu Me - #t Lys Lys Gln Leu Asn# 245- TCA ATC TCC GAA GAA ATG AGG GAC CTA GCC AA - #T CGT TTT CCT GTC ACT 939Ser Ile Ser Glu Glu Met Arg Asp Leu Ala As - #n Arg Phe Pro Val Thr250 2 - #55 2 - #60 2 -#65- TGC AGA AAT TTG GAA ACT CTC CAG AGG GTT CC - #T GTA ATA TTG AAG AGT 987Cys Arg Asn Leu Glu Thr Leu Gln Arg Val Pr - #o Val Ile Leu Lys Ser# 280- ATT TCA GAA AAT CTC TGT TCA TTG AGA AAA GT - #G ATC TGT GGT CCT ACA1035Ile Ser Glu Asn Leu Cys Ser Leu Arg Lys Va - #l Ile Cys Gly Pro Thr# 295- AAC ACT GAG ACT AGA CTG AAG CCG GGC AGT AG - #T TTT AAT TTA CTG TCA1083Asn Thr Glu Thr Arg Leu Lys Pro Gly Ser Se - #r Phe Asn Leu Leu Ser# 310- TCA GAG GAT TCA GCT GCT GCT GGA GAA AAA GA - #G AAA CAG ATT GGA AAA1131Ser Glu Asp Ser Ala Ala Ala Gly Glu Lys Gl - #u Lys Gln Ile Gly Lys# 325- CAT AGT ACT TTT GCT AAA ATT AAA GAA GAA CC - #A TGG GAC CCA GAA CTT1179His Ser Thr Phe Ala Lys Ile Lys Glu Glu Pr - #o Trp Asp Pro Glu Leu330 3 - #35 3 - #40 3 -#45- GAC AGT TTA GTG AAG CAA GAG GAG GTT GAT GT - #A TTT AGA AAT CAA GTG1227Asp Ser Leu Val Lys Gln Glu Glu Val Asp Va - #l Phe Arg Asn Gln Val# 360- AAG CAA GAA AAA GGT GAA TCT GAA AAT GAA AT - #A GAA GAC AAT CTG TTG1275Lys Gln Glu Lys Gly Glu Ser Glu Asn Glu Il - #e Glu Asp Asn Leu Leu# 375- AGA GAA GAT ATG GAA AGA ACT TGT GTG ATT CC - #T AGT ATT TCA GAA AAT1323Arg Glu Asp Met Glu Arg Thr Cys Val Ile Pr - #o Ser Ile Ser Glu Asn# 390- GAA CTC CAA GAT TTG GAA CAG CAA GCT AAA GA - #A GAA AAA TAT AAT GAT1371Glu Leu Gln Asp Leu Glu Gln Gln Ala Lys Gl - #u Glu Lys Tyr Asn Asp# 405- GTT TCT CAC CAA CTT TCT GAG CAT TTA TCT CC - #C AAT GAT GAT GAG AAT1419Val Ser His Gln Leu Ser Glu His Leu Ser Pr - #o Asn Asp Asp Glu Asn410 4 - #15 4 - #20 4 -#25- GAC TCC TCC TAT ATA ATT GAA AGT GAT GAA GA - #T TTG GAA ATG GAG ATG1467Asp Ser Ser Tyr Ile Ile Glu Ser Asp Glu As - #p Leu Glu Met Glu Met# 440- CTG AAG TCT TTA GAA AAC CTA AAT AGT GAC GT - #G GTG GAA CCC ACT CAC1515Leu Lys Ser Leu Glu Asn Leu Asn Ser Asp Va - #l Val Glu Pro Thr His# 455- TCT ACA TGG TTG GAA ATG GGA ACC AAT GGG CG - #T CTT CCT CCT GAG GAG1563Ser Thr Trp Leu Glu Met Gly Thr Asn Gly Ar - #g Leu Pro Pro Glu Glu# 470- GAA GAT GGA CAC GGA AAT GAA GCC ATC AAA GA - #G GAG CAG GAA GAA GAG1611Glu Asp Gly His Gly Asn Glu Ala Ile Lys Gl - #u Glu Gln Glu Glu Glu# 485- GAC CAT TTA TTG CCG GAA CCC AAC GCA AAG CA - #A ATT AAT TGC CTC AAG1659Asp His Leu Leu Pro Glu Pro Asn Ala Lys Gl - #n Ile Asn Cys Leu Lys490 4 - #95 5 - #00 5 -#05- ACC TAT TTC GGA CAC AGC AGT TTT AAA CCG GT - #T CAG TGG AAA GTC ATC1707Thr Tyr Phe Gly His Ser Ser Phe Lys Pro Va - #l Gln Trp Lys Val Ile# 520- CAT TCT GTA TTA GAA GAG AGA AGA GAT AAT GT - #T GTT GTC ATG GCA ACT1755His Ser Val Leu Glu Glu Arg Arg Asp Asn Va - #l Val Val Met Ala Thr# 535- GGA TAT GGG AAG AGT CTG TGC TTC CAG TAT CC - #G CCT GTT TAT ACA GGC1803Gly Tyr Gly Lys Ser Leu Cys Phe Gln Tyr Pr - #o Pro Val Tyr Thr Gly# 550- AAG ATT GGC ATT GTC ATT TCA CCT CTC ATT TC - #C TTA ATG GAA GAC CAA1851Lys Ile Gly Ile Val Ile Ser Pro Leu Ile Se - #r Leu Met Glu Asp Gln# 565- GTC CTC CAG CTT GAG CTG TCC AAT GTT CCA GC - #C TGT TTA CTT GGA TCT1899Val Leu Gln Leu Glu Leu Ser Asn Val Pro Al - #a Cys Leu Leu Gly Ser570 5 - #75 5 - #80 5 -#85- GCA CAG TCA AAA AAT ATT CTA GGA GAT GTT AA - #A TTA GGC AAA TAT AGG1947Ala Gln Ser Lys Asn Ile Leu Gly Asp Val Ly - #s Leu Gly Lys Tyr Arg# 600- GTC ATC TAC ATA ACT CCA GAG TTC TGT TCT GG - #T AAC TTG GAT CTA CTC1995Val Ile Tyr Ile Thr Pro Glu Phe Cys Ser Gl - #y Asn Leu Asp Leu Leu# 615- CAG CAA CTT GAC TCT AGT ATT GGC ATC ACT CT - #C ATT GCT GTG GAT GAG2043Gln Gln Leu Asp Ser Ser Ile Gly Ile Thr Le - #u Ile Ala Val Asp Glu# 630- GCT CAC TGC ATT TCA GAG TGG GGC CAT GAT TT - #C AGA AGT TCA TTC AGG2091Ala His Cys Ile Ser Glu Trp Gly His Asp Ph - #e Arg Ser Ser Phe Arg# 645- ATG CTG GGC TCT CTT AAA ACA GCG CTC CCA TT - #G GTT CCA GTC ATT GCA2139Met Leu Gly Ser Leu Lys Thr Ala Leu Pro Le - #u Val Pro Val Ile Ala650 6 - #55 6 - #60 6 -#65- CTC TCC GCT ACT GCA AGC TCT TCC ATC CGG GA - #A GAC ATT ATA AGC TGC2187Leu Ser Ala Thr Ala Ser Ser Ser Ile Arg Gl - #u Asp Ile Ile Ser Cys# 680- TTA AAC CTG AAA GAC CCT CAG ATC ACC TGC AC - #T GGA TTT GAT CGG CCA2235Leu Asn Leu Lys Asp Pro Gln Ile Thr Cys Th - #r Gly Phe Asp Arg Pro# 695- AAT CTG TAC TTA GAA GTT GGA CGG AAA ACA GG - #G AAC ATC CTT CAG GAT2283Asn Leu Tyr Leu Glu Val Gly Arg Lys Thr Gl - #y Asn Ile Leu Gln Asp# 710- CTA AAG CCG TTT CTC GTC CGA AAG GCA AGT TC - #T GCC TGG GAA TTT GAA2331Leu Lys Pro Phe Leu Val Arg Lys Ala Ser Se - #r Ala Trp Glu Phe Glu# 725- GGT CCA ACC ATC ATC TAT TGT CCT TCG AGA AA - #A ATG ACA GAA CAA GTT2379Gly Pro Thr Ile Ile Tyr Cys Pro Ser Arg Ly - #s Met Thr Glu Gln Val730 7 - #35 7 - #40 7 -#45- ACT GCT GAA CTT GGG AAA CTG AAC TTA GCC TG - #C AGA ACA TAC CAC GCT2427Thr Ala Glu Leu Gly Lys Leu Asn Leu Ala Cy - #s Arg Thr Tyr His Ala# 760- GGC ATG AAA ATT AGC GAA AGG AAG GAC GTT CA - #T CAT AGG TTC CTG AGA2475Gly Met Lys Ile Ser Glu Arg Lys Asp Val Hi - #s His Arg Phe Leu Arg# 775- GAT GAA ATT CAG TGT GTT GTA GCT ACT GTA GC - #T TTT GGA ATG GGC ATT2523Asp Glu Ile Gln Cys Val Val Ala Thr Val Al - #a Phe Gly Met Gly Ile# 790- AAT AAA GCT GAC ATT CGC AAA GTT ATT CAT TA - #T GGT GCG CCT AAG GAA2571Asn Lys Ala Asp Ile Arg Lys Val Ile His Ty - #r Gly Ala Pro Lys Glu# 805- ATG GAA TCC TAT TAC CAG GAA ATT GGT AGA GC - #T GGC CGG GAT GGA CTT2619Met Glu Ser Tyr Tyr Gln Glu Ile Gly Arg Al - #a Gly Arg Asp Gly Leu810 8 - #15 8 - #20 8 -#25- CAG AGT TCC TGT CAC TTG CTC TGG GCT CCA GC - #A GAC TTT AAC ACA TCC2667Gln Ser Ser Cys His Leu Leu Trp Ala Pro Al - #a Asp Phe Asn Thr Ser# 840- AGG AAT CTC CTT ATT GAG ATT CAC GAT GAA AA - #G TTC CGG TTA TAT AAA2715Arg Asn Leu Leu Ile Glu Ile His Asp Glu Ly - #s Phe Arg Leu Tyr Lys# 855- TTA AAG ATG ATG GTA AAG ATG GAA AAA TAC CT - #T CAC TCC AGT CAG TGT2763Leu Lys Met Met Val Lys Met Glu Lys Tyr Le - #u His Ser Ser Gln Cys# 870- AGG CGA CGA ATC ATC TTG TCC CAT TTT GAG GA - #C AAA TGT CTG CAG AAG2811Arg Arg Arg Ile Ile Leu Ser His Phe Glu As - #p Lys Cys Leu Gln Lys# 885- GCC TCC TTG GAC ATT ATG GGA ACT GAA AAA TG - #C TGT GAT AAT TGC AGG2859Ala Ser Leu Asp Ile Met Gly Thr Glu Lys Cy - #s Cys Asp Asn Cys Arg890 8 - #95 9 - #00 9 -#05- CCC AGG CTG AAT CAT TGC ATT ACT GCT AAC AA - #C TCA GAG GAC GCA TCC2907Pro Arg Leu Asn His Cys Ile Thr Ala Asn As - #n Ser Glu Asp Ala Ser# 920- CAA GAC TTT GGG CCA CAA GCA TTC CAG CTA CT - #G TCT GCT GTG GAC ATC2955Gln Asp Phe Gly Pro Gln Ala Phe Gln Leu Le - #u Ser Ala Val Asp Ile# 935- CTG CAG GAG AAA TTT GGA ATT GGG ATT CCG AT - #C TTA TTT CTC CGA GGA3003Leu Gln Glu Lys Phe Gly Ile Gly Ile Pro Il - #e Leu Phe Leu Arg Gly# 950- TCT AAT TCT CAG CGT CTT CCT GAT AAA TAT CG - #G GGT CAC AGG CTC TTT3051Ser Asn Ser Gln Arg Leu Pro Asp Lys Tyr Ar - #g Gly His Arg Leu Phe# 965- GGT GCT GGA AAG GAG CAA GCA GAA AGT TGG TG - #G AAG ACC CTT TCT CAC3099Gly Ala Gly Lys Glu Gln Ala Glu Ser Trp Tr - #p Lys Thr Leu Ser His970 9 - #75 9 - #80 9 -#85- CAT CTC ATA GCT GAA GGA TTC TTG GTA GAA GT - #T CCC AAG GAA AAC AAA3147His Leu Ile Ala Glu Gly Phe Leu Val Glu Va - #l Pro Lys Glu Asn Lys# 1000- TAT ATA AAG ACA TGT TCC CTC ACA AAA AAG GG - #T AGA AAG TGG CTT GGA3195Tyr Ile Lys Thr Cys Ser Leu Thr Lys Lys Gl - #y Arg Lys Trp Leu Gly# 10150- GAA GCC AGT TCG CAG TCT CCT CCG AGC CTT CT - #C CTT CAA GCT AAT GAA3243Glu Ala Ser Ser Gln Ser Pro Pro Ser Leu Le - #u Leu Gln Ala Asn Glu# 10305- GAG ATG TTT CCA AGG AAA GTT CTG CTA CCA AG - #T TCT AAT CCT GTA TCT3291Glu Met Phe Pro Arg Lys Val Leu Leu Pro Se - #r Ser Asn Pro Val Ser# 10450- CCA GAA ACG ACG CAA CAT TCC TCT AAT CAA AA - #C CCA GCT GGA TTA ACT3339Pro Glu Thr Thr Gln His Ser Ser Asn Gln As - #n Pro Ala Gly Leu Thr# 10651055 - # 1060- ACC AAG CAG TCT AAT TTG GAG AGA ACG CAT TC - #T TAC AAA GTG CCT GAG3387Thr Lys Gln Ser Asn Leu Glu Arg Thr His Se - #r Tyr Lys Val Pro Glu# 10805- AAA GTT TCT TCT GGG ACT AAC ATT CCT AAA AA - #A AGT GCC GTG ATG CCG3435Lys Val Ser Ser Gly Thr Asn Ile Pro Lys Ly - #s Ser Ala Val Met Pro# 10950- TCA CCA GGA ACA TCT TCC AGC CCC TTA GAA CC - #T GCC ATC TCA GCC CAA3483Ser Pro Gly Thr Ser Ser Ser Pro Leu Glu Pr - #o Ala Ile Ser Ala Gln# 11105- GAG CTG GAC GCT CGG ACT GGG CTA TAT GCC AG - #G CTG GTG GAA GCA AGG3531Glu Leu Asp Ala Arg Thr Gly Leu Tyr Ala Ar - #g Leu Val Glu Ala Arg# 11250- CAG AAA CAC GCT AAT AAG ATG GAT GTA CCT CC - #A GCT ATT TTA GCA ACA3579Gln Lys His Ala Asn Lys Met Asp Val Pro Pr - #o Ala Ile Leu Ala Thr# 11451135 - # 1140- AAC AAG GTT CTG CTG GAC ATG GCT AAA ATG AG - #A CCG ACT ACT GTT GAA3627Asn Lys Val Leu Leu Asp Met Ala Lys Met Ar - #g Pro Thr Thr Val Glu# 11605- AAC ATG AAA CAG ATC GAC GGT GTC TCT GAA GG - #C AAA GCT GCT CTG TTG3675Asn Met Lys Gln Ile Asp Gly Val Ser Glu Gl - #y Lys Ala Ala Leu Leu# 11750- GCC CCT CTG TTG GAA GTC ATC AAA CAT TTC TG - #T CAA GTA ACT AGT GTT3723Ala Pro Leu Leu Glu Val Ile Lys His Phe Cy - #s Gln Val Thr Ser Val# 11905- CAG ACA GAC CTC CTT TCC AGT GCC AAA CCT CA - #C AAG GAA CAG GAG AAA3771Gln Thr Asp Leu Leu Ser Ser Ala Lys Pro Hi - #s Lys Glu Gln Glu Lys# 12050- AGT CAG GAG ATG GAA AAG AAA GAC TGC TCA CT - #C CCC CAG TCT GTG GCC3819Ser Gln Glu Met Glu Lys Lys Asp Cys Ser Le - #u Pro Gln Ser Val Ala# 12251215 - # 1220- GTC ACA TAC ACT CTA TTC CAG GAA AAG AAA AT - #G CCC TTA CAC AGC ATA3867Val Thr Tyr Thr Leu Phe Gln Glu Lys Lys Me - #t Pro Leu His Ser Ile# 12405- GCT GAG AAC AGG CTC CTG CCT CTC ACA GCA GC - #C GGC ATG CAC TTA GCC3915Ala Glu Asn Arg Leu Leu Pro Leu Thr Ala Al - #a Gly Met His Leu Ala# 12550- CAG GCG GTG AAA GCC GGC TAC CCC CTG GAT AT - #G GAG CGA GCT GGC CTG3963Gln Ala Val Lys Ala Gly Tyr Pro Leu Asp Me - #t Glu Arg Ala Gly Leu# 12705- ACC CCA GAG ACT TGG AAG ATT ATT ATG GAT GT - #C ATC CGA AAC CCT CCC4011Thr Pro Glu Thr Trp Lys Ile Ile Met Asp Va - #l Ile Arg Asn Pro Pro# 12850- ATC AAC TCA GAT ATG TAT AAA GTT AAA CTC AT - #C AGA ATG TTA GTT CCT4059Ile Asn Ser Asp Met Tyr Lys Val Lys Leu Il - #e Arg Met Leu Val Pro# 13051295 - # 1300- GAA AAC TTA GAC ACG TAC CTC ATC CAC ATG GC - #G ATT GAG ATT CTT CAG4107Glu Asn Leu Asp Thr Tyr Leu Ile His Met Al - #a Ile Glu Ile Leu Gln# 13205- AGT GGT TCC GAC AGC AGA ACC CAG CCT CCT TG - #T GAT TCC AGC AGG AAG4155Ser Gly Ser Asp Ser Arg Thr Gln Pro Pro Cy - #s Asp Ser Ser Arg Lys# 13350- AGG CGT TTC CCC AGC TCT GCA GAG AGT TGT GA - #G AGC TGT AAG GAG AGC4203Arg Arg Phe Pro Ser Ser Ala Glu Ser Cys Gl - #u Ser Cys Lys Glu Ser# 13505- AAA GAG GCG GTC ACC GAG ACC AAG GCA TCA TC - #T TCA GAG TCA AAG AGA4251Lys Glu Ala Val Thr Glu Thr Lys Ala Ser Se - #r Ser Glu Ser Lys Arg# 13650- AAA TTA CCC GAG TGG TTT GCC AAA GGA AAT GT - #G CCC TCA GCT GAT ACC4299Lys Leu Pro Glu Trp Phe Ala Lys Gly Asn Va - #l Pro Ser Ala Asp Thr# 13851375 - # 1380- GGC AGC TCA TCA TCA ATG GCC AAG ACC AAA AA - #G AAA GGT CTC TTT AGT4347Gly Ser Ser Ser Ser Met Ala Lys Thr Lys Ly - #s Lys Gly Leu Phe Ser# 14005- TAANATGACN ACGATGGAAC AGTTTGTGTG TCCTACATCT TCATTCCTAT AA - #AGAATGAA4407- NAGAAATATT TTAACCTCAA AATTATTTAA AGTCCAAAGT GAAGCTCACC TA - #AACGTCGA4467- GCCATAGAGT CTTTAATTGN CCGTTGGCAG TTGAGCTACA GTATCTGAAC CT - #TCTGAGAC4527- CCGGAGTGCA GCATAGACTG TGAAGTCGGC TTCCTTTCCG ATTGCCTTCC GA - #ACCCGTGT4587- CACTGTCAGG TTGCAGTCTT TCTCTTCTTG CAGCAGTGTG TGTTGGAAAT GG - #AGGCTGTG4647- TCGCTTTGAC ATATAGAACA GATCAGTANT TGCATAGGGA CAGATATGAA GA - #TNCAGCCG4707- GTCTTTGCTT TCTTATGCAG ATGCCTGTAT GACAGTATCA GTGCACCAGC CC - #AGCCAGGG4767# 4792 TTAA AAAGG- (2) INFORMATION FOR SEQ ID NO:206:- (i) SEQUENCE CHARACTERISTICS:#acids (A) LENGTH: 1401 amino (B) TYPE: amino acid (D) TOPOLOGY: linear- (ii) MOLECULE TYPE: protein- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:206:- Met Glu Thr Thr Ser Leu Gln Arg Lys Phe Pr - #o Glu Trp Met Ser Met# 15- Gln Ser Gln Arg Cys Ala Thr Glu Glu Lys Al - #a Cys Val Gln Lys Ser# 30- Val Leu Glu Asp Asn Leu Pro Phe Leu Glu Ph - #e Pro Gly Ser Ile Val# 45- Tyr Ser Tyr Glu Ala Ser Asp Cys Ser Phe Le - #u Ser Glu Asp Ile Ser# 60- Met Arg Leu Ser Asp Gly Asp Val Val Gly Ph - #e Asp Met Glu Trp Pro# 80- Pro Ile Tyr Lys Pro Gly Lys Arg Ser Arg Va - #l Ala Val Ile Gln Leu# 95- Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe Hi - #s Ile Ser Ser Met Ser# 110- Val Phe Pro Gln Gly Leu Lys Met Leu Leu Gl - #u Asn Lys Ser Ile Lys# 125- Lys Ala Gly Val Gly Ile Glu Gly Asp Gln Tr - #p Lys Leu Leu Arg Asp# 140- Phe Asp Val Lys Leu Glu Ser Phe Val Glu Le - #u Thr Asp Val Ala Asn145 1 - #50 1 - #55 1 -#60- Glu Lys Leu Lys Cys Ala Glu Thr Trp Ser Le - #u Asn Gly Leu Val Lys# 175- His Val Leu Gly Lys Gln Leu Leu Lys Asp Ly - #s Ser Ile Arg Cys Ser# 190- Asn Trp Ser Asn Phe Pro Leu Thr Glu Asp Gl - #n Lys Leu Tyr Ala Ala# 205- Thr Asp Ala Tyr Ala Gly Leu Ile Ile Tyr Gl - #n Lys Leu Gly Asn Leu# 220- Gly Asp Thr Ala Gln Val Phe Ala Leu Asn Ly - #s Ala Glu Glu Asn Leu225 2 - #30 2 - #35 2 -#40- Pro Leu Glu Met Lys Lys Gln Leu Asn Ser Il - #e Ser Glu Glu Met Arg# 255- Asp Leu Ala Asn Arg Phe Pro Val Thr Cys Ar - #g Asn Leu Glu Thr Leu# 270- Gln Arg Val Pro Val Ile Leu Lys Ser Ile Se - #r Glu Asn Leu Cys Ser# 285- Leu Arg Lys Val Ile Cys Gly Pro Thr Asn Th - #r Glu Thr Arg Leu Lys# 300- Pro Gly Ser Ser Phe Asn Leu Leu Ser Ser Gl - #u Asp Ser Ala Ala Ala305 3 - #10 3 - #15 3 -#20- Gly Glu Lys Glu Lys Gln Ile Gly Lys His Se - #r Thr Phe Ala Lys Ile# 335- Lys Glu Glu Pro Trp Asp Pro Glu Leu Asp Se - #r Leu Val Lys Gln Glu# 350- Glu Val Asp Val Phe Arg Asn Gln Val Lys Gl - #n Glu Lys Gly Glu Ser# 365- Glu Asn Glu Ile Glu Asp Asn Leu Leu Arg Gl - #u Asp Met Glu Arg Thr# 380- Cys Val Ile Pro Ser Ile Ser Glu Asn Glu Le - #u Gln Asp Leu Glu Gln385 3 - #90 3 - #95 4 -#00- Gln Ala Lys Glu Glu Lys Tyr Asn Asp Val Se - #r His Gln Leu Ser Glu# 415- His Leu Ser Pro Asn Asp Asp Glu Asn Asp Se - #r Ser Tyr Ile Ile Glu# 430- Ser Asp Glu Asp Leu Glu Met Glu Met Leu Ly - #s Ser Leu Glu Asn Leu# 445- Asn Ser Asp Val Val Glu Pro Thr His Ser Th - #r Trp Leu Glu Met Gly# 460- Thr Asn Gly Arg Leu Pro Pro Glu Glu Glu As - #p Gly His Gly Asn Glu465 4 - #70 4 - #75 4 -#80- Ala Ile Lys Glu Glu Gln Glu Glu Glu Asp Hi - #s Leu Leu Pro Glu Pro# 495- Asn Ala Lys Gln Ile Asn Cys Leu Lys Thr Ty - #r Phe Gly His Ser Ser# 510- Phe Lys Pro Val Gln Trp Lys Val Ile His Se - #r Val Leu Glu Glu Arg# 525- Arg Asp Asn Val Val Val Met Ala Thr Gly Ty - #r Gly Lys Ser Leu Cys# 540- Phe Gln Tyr Pro Pro Val Tyr Thr Gly Lys Il - #e Gly Ile Val Ile Ser545 5 - #50 5 - #55 5 -#60- Pro Leu Ile Ser Leu Met Glu Asp Gln Val Le - #u Gln Leu Glu Leu Ser# 575- Asn Val Pro Ala Cys Leu Leu Gly Ser Ala Gl - #n Ser Lys Asn Ile Leu# 590- Gly Asp Val Lys Leu Gly Lys Tyr Arg Val Il - #e Tyr Ile Thr Pro Glu# 605- Phe Cys Ser Gly Asn Leu Asp Leu Leu Gln Gl - #n Leu Asp Ser Ser Ile# 620- Gly Ile Thr Leu Ile Ala Val Asp Glu Ala Hi - #s Cys Ile Ser Glu Trp625 6 - #30 6 - #35 6 -#40- Gly His Asp Phe Arg Ser Ser Phe Arg Met Le - #u Gly Ser Leu Lys Thr# 655- Ala Leu Pro Leu Val Pro Val Ile Ala Leu Se - #r Ala Thr Ala Ser Ser# 670- Ser Ile Arg Glu Asp Ile Ile Ser Cys Leu As - #n Leu Lys Asp Pro Gln# 685- Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Le - #u Tyr Leu Glu Val Gly# 700- Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Ly - #s Pro Phe Leu Val Arg705 7 - #10 7 - #15 7 -#20- Lys Ala Ser Ser Ala Trp Glu Phe Glu Gly Pr - #o Thr Ile Ile Tyr Cys# 735- Pro Ser Arg Lys Met Thr Glu Gln Val Thr Al - #a Glu Leu Gly Lys Leu# 750- Asn Leu Ala Cys Arg Thr Tyr His Ala Gly Me - #t Lys Ile Ser Glu Arg# 765- Lys Asp Val His His Arg Phe Leu Arg Asp Gl - #u Ile Gln Cys Val Val# 780- Ala Thr Val Ala Phe Gly Met Gly Ile Asn Ly - #s Ala Asp Ile Arg Lys785 7 - #90 7 - #95 8 -#00- Val Ile His Tyr Gly Ala Pro Lys Glu Met Gl - #u Ser Tyr Tyr Gln Glu# 815- Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Se - #r Ser Cys His Leu Leu# 830- Trp Ala Pro Ala Asp Phe Asn Thr Ser Arg As - #n Leu Leu Ile Glu Ile# 845- His Asp Glu Lys Phe Arg Leu Tyr Lys Leu Ly - #s Met Met Val Lys Met# 860- Glu Lys Tyr Leu His Ser Ser Gln Cys Arg Ar - #g Arg Ile Ile Leu Ser865 8 - #70 8 - #75 8 -#80- His Phe Glu Asp Lys Cys Leu Gln Lys Ala Se - #r Leu Asp Ile Met Gly# 895- Thr Glu Lys Cys Cys Asp Asn Cys Arg Pro Ar - #g Leu Asn His Cys Ile# 910- Thr Ala Asn Asn Ser Glu Asp Ala Ser Gln As - #p Phe Gly Pro Gln Ala# 925- Phe Gln Leu Leu Ser Ala Val Asp Ile Leu Gl - #n Glu Lys Phe Gly Ile# 940- Gly Ile Pro Ile Leu Phe Leu Arg Gly Ser As - #n Ser Gln Arg Leu Pro945 9 - #50 9 - #55 9 -#60- Asp Lys Tyr Arg Gly His Arg Leu Phe Gly Al - #a Gly Lys Glu Gln Ala# 975- Glu Ser Trp Trp Lys Thr Leu Ser His His Le - #u Ile Ala Glu Gly Phe# 990- Leu Val Glu Val Pro Lys Glu Asn Lys Tyr Il - #e Lys Thr Cys Ser Leu# 10050- Thr Lys Lys Gly Arg Lys Trp Leu Gly Glu Al - #a Ser Ser Gln Ser Pro# 10205- Pro Ser Leu Leu Leu Gln Ala Asn Glu Glu Me - #t Phe Pro Arg Lys Val# 10401030 - # 1035- Leu Leu Pro Ser Ser Asn Pro Val Ser Pro Gl - #u Thr Thr Gln His Ser# 10550- Ser Asn Gln Asn Pro Ala Gly Leu Thr Thr Ly - #s Gln Ser Asn Leu Glu# 10705- Arg Thr His Ser Tyr Lys Val Pro Glu Lys Va - #l Ser Ser Gly Thr Asn# 10850- Ile Pro Lys Lys Ser Ala Val Met Pro Ser Pr - #o Gly Thr Ser Ser Ser# 11005- Pro Leu Glu Pro Ala Ile Ser Ala Gln Glu Le - #u Asp Ala Arg Thr Gly# 11201110 - # 1115- Leu Tyr Ala Arg Leu Val Glu Ala Arg Gln Ly - #s His Ala Asn Lys Met# 11350- Asp Val Pro Pro Ala Ile Leu Ala Thr Asn Ly - #s Val Leu Leu Asp Met# 11505- Ala Lys Met Arg Pro Thr Thr Val Glu Asn Me - #t Lys Gln Ile Asp Gly# 11650- Val Ser Glu Gly Lys Ala Ala Leu Leu Ala Pr - #o Leu Leu Glu Val Ile# 11805- Lys His Phe Cys Gln Val Thr Ser Val Gln Th - #r Asp Leu Leu Ser Ser# 12001190 - # 1195- Ala Lys Pro His Lys Glu Gln Glu Lys Ser Gl - #n Glu Met Glu Lys Lys# 12150- Asp Cys Ser Leu Pro Gln Ser Val Ala Val Th - #r Tyr Thr Leu Phe Gln# 12305- Glu Lys Lys Met Pro Leu His Ser Ile Ala Gl - #u Asn Arg Leu Leu Pro# 12450- Leu Thr Ala Ala Gly Met His Leu Ala Gln Al - #a Val Lys Ala Gly Tyr# 12605- Pro Leu Asp Met Glu Arg Ala Gly Leu Thr Pr - #o Glu Thr Trp Lys Ile# 12801270 - # 1275- Ile Met Asp Val Ile Arg Asn Pro Pro Ile As - #n Ser Asp Met Tyr Lys# 12950- Val Lys Leu Ile Arg Met Leu Val Pro Glu As - #n Leu Asp Thr Tyr Leu# 13105- Ile His Met Ala Ile Glu Ile Leu Gln Ser Gl - #y Ser Asp Ser Arg Thr# 13250- Gln Pro Pro Cys Asp Ser Ser Arg Lys Arg Ar - #g Phe Pro Ser Ser Ala# 13405- Glu Ser Cys Glu Ser Cys Lys Glu Ser Lys Gl - #u Ala Val Thr Glu Thr# 13601350 - # 1355- Lys Ala Ser Ser Ser Glu Ser Lys Arg Lys Le - #u Pro Glu Trp Phe Ala# 13750- Lys Gly Asn Val Pro Ser Ala Asp Thr Gly Se - #r Ser Ser Ser Met Ala# 13905- Lys Thr Lys Lys Lys Gly Leu Phe Ser# 1400- (2) INFORMATION FOR SEQ ID NO:207:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 29604 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207:- TGAGGTTATT CTTTGAAGGG GACAGAATCC CATTTCACTT TTACTAGATA AG - #AATTTAGA 60- ACCTAACATC TGCCACCGTA GACTCTGAGT TATTAAATTG AGAGGAAATG GC - #CAAAGTGT 120- ATCCTGTAAT GAAATAATCC TCATATGAAA TTGTTCTTAT ATGACATTGG AA - #GACCTGTC 180- TTGCTCTGTC TTTTCAGTTT TGGATACATT TTCTTGACAC AAACCGGTAT CA - #GAGCCAGA 240- CTCTTTTCTG CTCTAACATC TTGCTTCTGT ACGTTATAAT CCTCAGTCCT CA - #AGCGGTCT 300- CTAACATCTT GCTTCTGTAC GTTATAATCC TCAGTCCTCA AGCGGTCTTC GG - #CGACGTCA 360- GCTACTCTTT TTTTGTACAG AGTGATGGTT ATAAAGTCTT CTTGTTGAAA AT - #CACTGTGA 420- ACTTAGTAGC TATAGTAAAA TTTTCATAAA GATCCGTAGA AATTAAAATT AT - #AGCATAAA 480- TATACAACTA GCTTTTTCTA ACATTTTGTT ATCAGATTTC AGAATAATCA TA - #CATTTTTT 540- ACATTTTTAC TAAAAAATGA GTATTTACAT ATTTGACCAA AATAAAATTG AA - #CCATTTTA 600- GATAATTATT GAAACAATTT CCACATTAAG CAGTATAACT GCCAATTAGT TA - #ATTGCTGA 660- ATGATTACAT ATTAGTTATT AATATTGTCT AGCAACAACT TTATCTTATA CT - #CAAAATGA 720- TTATATTGGC CATTTAACTT AATTAAGTTT CTCGCTTTTT TAATGCTTTT AG - #AAAAGATT 780- GGGATGCCTT ATTTAGTTTA GCCCTCAAGC AATTAGGTGA GGCAATTACC AT - #GGTAACAG 840- AAGGTATTCA TTTCCTTACC TTAGCTAAAG GTTTTGGGAA CAAAGAAACC TC - #TCAGCTCA 900- TCCATTGAAA CCCAACTTTC TCCTGAGCCT GGCATTAAGT GTTTGTTCTC TA - #AAAGAGGA 960- CTTAATTTTA AGTGGGGAAA ACATGCCCCT GAGCTGAGTC TCTTTGTCAT AG - #GGCGATTA1020- AAAAGCTACC TCTTCTTAAT AGGAAGTGTG GTCTTAACTT TTATATTTCA CA - #TTTTATAT1080- TGAGAATTTC TACACTCATA TAATGTTTTG ATCAAACTTT CCCTTTAAAT CC - #TTGCCTTC1140- CCTATCCTCT TTCTTCCTTT GTTTCCTTCT TTGTTTGTTT CTCTCTCTCT CT - #CTCTCTCT1200- CTCTCTCTCT CTCTCTCTCT CTCTTTCTTT CTTTCCTTCA AATGCCCTGA AC - #GTCCTTAC1260- GCTGCTTCTC GCTGCATGAG TACAGGATCA CCTGAGATAC CTACCTAGCT GT - #CAGGAACC1320- ACATCCTGAA GAAGACAGAC CCTTGCTTCC CCAGTGGCTG GCTATCTGTT GC - #CAATACTG1380- TAGGCTTCAT GAGCTTCCCC TCAGTGCACG CTGAGATTTG GCTGGCTTGA TT - #TTTTTGCA1440- TGCAGACATA GCCTCTGAGA TGGACAATAA TCCTGCCAAC AGTCTTCCTG CC - #CCTCTTCT1500- GCAATGATTC CCAAGCCTTG TGACATGGGA GTCACATTTA GAGCTGGTCA GT - #TTTTGTTC1560- TTTTTTCTTT TGTTTTGAAT TAAACTCGAA ATCTCATTGG TATGCTCTCT TT - #TGACAAAA1620- GGATACCAGA CCACCTCTCC TAACGGTCTA ATTGCTGTCA AATAAAATCA CT - #TAAGGTGT1680- ATTTTTCAAC ACATAATTTA TAGTTTTTGA CAGGTAATTT ATTAATATTT AT - #TTGGCTAG1740- TTCTACCATT CCCAAGCAGA AAGTCTACTT ACTAAATTAG CTATCATGAG GC - #AAATTTTG1800- TAACTAATTT ATCAAAAATT CTGGTCATGG TGGTGCATAT CTATAATCCT AT - #CACCCAGG1860- ATTGTGGTTC AAGGCCAATC TCAAAGGAAA CTTTGTCTCA AAACAAACAA AC - #AAACAAAC1920- AAACAAATTA ACATGAAACA GAACACATTA AAAAAACCCA GGGTTTTTAC CA - #GAAATTTA1980- ATTATTAAAT ATATCTTGGA AATTAAAACC AGACAACAAC AACAACAACA TC - #AACCCACC2040- CTGAGTATGC TGTTAAAAAT ACCAGTACTA GAGGCCTGGA GACATTGCTC AT - #GCTTGAGA2100- CTATTAAGCA TTCTTACAGA AGAATGGGTT CTGTTTCTTG CAACCTCATG GT - #GGCTCACA2160- GCTCCCAGTA TATGGACATC TGAGACTGGA AATGATAGGA AGAATTAAGG CT - #TTACACAA2220- ATATCTGTCT AAAAACACGC ATGCGCCAGG CTGTCTATAT ACAGCGACTC CT - #GAATATTC2280- ACACTTGCAT TTAATTTGAA TTCTGCATTG TGATGCCATA TAAACTGTTA AG - #TGCAGTGG2340- AATTCAGGAA CTTGTGGTAC TTTCTGTTTA GTTTAAGATT AAAAGTGCAG TT - #ACTATGTA2400- GTGGGTAAAG GTGCTTGCTT TGCAAGCCTG ACAGCCTGGC TCAGGGTTCA GC - #CTCTGTGT2460- GATGTAGGAG AGAAGCACAC CAGAGCATCA GTAACACTGT CAGGCATTGG TG - #CCTCTCAT2520- GAGCTGGATC CCAAGTTGGG CCTGTCATTC CTGTTCCCCA GGCTCTTCTC CA - #TATTTTTC2580- CCTGCAGTTC CTTTAGACAG GAACAATTCT GAGTCAGAGT TTTTGACTGT GG - #GATGACAA2640- CCCCATCCCT CCACTTGGTG CCCTGTCTTT CTATTGGAGG TGGACTCTAC AA - #GTTCCCTC2700- TCCCCACTTT TGAGCATTTC GTCTAAGGTC CCTTGCTTTG AGTCCTGAGA GT - #CTCTCACC2760- TCCGAGGTCT CTGGTACTTT CTAGAGGGTC CCCCCATTTG AGGGCAACTG AC - #AGTGCATT2820- GAGCTTACCA AATATTTTGT AAACTTCTTG TTGTTCAGAT TTAATTACAT CT - #TTAAAGAG2880- TTTTGTCCCT AGCTATCGTT CTCGCCGGCA AGAACACACG CGGACAACCG GA - #TTCTTCTG2940- CGGCAAGCTT TATTGCTTCT TAAGGAGGGA AGACCCAGAC CCTGGAAAAT GG - #TGCTGCTT3000- ATATAGCCCT CAGCGTGGCG TTTCAGCACC TGATGTGGCA TGTCACCTCC TG - #ATTTGTTG3060- CTCGCCCATC ACTTCATTAC TATGCCCCGA GATGGGCAGT GACTAGGCGT GA - #GTTCACTC3120- TTGCACTTGC GCACAAGGCT TGTTTATTAG GCACAGCGGA AGCCAGCGCC AT - #CTTATAAT3180- GGTGATTACT CGCGGCACGG CTCTCCACAG AGTTTACCAG AAAATGTATT CA - #TAAAATGA3240- GTGTTATATT ACTTTCCTGT TATATTTATT CCCAATAATA TTGTTTATTT TA - #TTGTATAG3300- CTTTTTGCTA TTGTAAATAT AATTTTGACT CTGCCCTAAT TTCTGAGGAT GC - #ATTGTCAT3360- ATCAGAAAAA GTTTTATTAT AGTTTCTATT GTGTTTCTAT AGTTTTTATT AT - #AGTTTCTA3420- GTTCAAACCA TATTACTGTT TTCTTTATCA ATTGAAAAAG AGCTACTTTT TA - #AATTATAG3480- GCTCCTTGGT TCTCTGGTTA TAAACAATGG TATGCAAAAT AAAACCATTT AC - #CACTGTGT3540- CTCTTAAAAA GAAAGTAGGA GATAACTGAC TTCACAAAGT TGCTCTGTGA TC - #CCCCACGC3600- ATGTGTCATG GTGGGAGCTT GCTGGCATTC AAACATAAAC ATATCACAAA CG - #CACACACA3660- TGCACACATA CTCTCTCTCT CTCACACATG CACACACACA CAATTTGTTA TT - #TCACTATT3720- GAAGTCTTGA GAGACCAAAA GAAGGTTTTA CACTAAAAGG AACATTTTTA AT - #TATCCCCT3780- CTGTTTCCTT TTTGAAGACT TGTAATATAA TTACATTATA GTTAAAACTG TA - #GCAATCAC3840- AGATCACAGG GAAGATGCCC TGATAGCCCA GAAGTAGTAG CATGAAACAA TG - #TTTAATTA3900- ATGCTGTCTG ACTCTCAAAT AATAACTAAT AGTACTAACA GAGCAGATGA GA - #GCTTTTAA3960- TAGTATTTTG AAAATATTTT ATATAAAATT TAGTCATATT CAAAGCTGTC TA - #TATGATTG4020- GAAGGAATTA ACATGTCTCC TCTTTAAGGA AACAGAGACT CTCTTAGCTT TA - #AGGGCTTT4080- GTGCCCTTGG TAATCCATGT AAGGGGCCTG AACTGCTGCA CAGCAGTTGG TT - #GTAAAGAA4140- GTTTTTAGAC TGCCAAGCGA GACACTCCTC CTGCTGTTTG CTACCACTTG AT - #TAGAAAAT4200- AGTTTGTGTG GTGGTTGTTA AATAAAATTC AAGTCATGAT CAAAAGTAAG CA - #TAAAGTCC4260- AATATATAGT AACCTTAATA ATGGGGGGAG GAGAGTGAGT ACTTGTCGAG TG - #TTCAAGAA4320- GTCTCAGGTT CCGTCCACAG TCCCACATAC ACCAGGCACA GGGGCACAGA CC - #TGTCATCT4380- CATCTCAGTA CGCGGGCAAG AAAATCAGGA GTTCAAAGCC ATCCTTGGCT AC - #ATAGCAAG4440- TTTGAGGCCA GCGTAGACGT CATGACATTC TGTCTCAATA AAACAAGCAA CA - #ACAAGAAC4500- ACTCCCCAAA CAACAACCTT CCCTCAAGTC CAAAGAAGAC TGAGACATGC GA - #GATGCACA4560- GTAAACTAAG GTCATCAGGA GTGTGAGGGG CTTAGAGAGG ATGGGTGGGG GG - #GACTACAC4620- TGTATGAAGC TGTCACAAAG ATGCACACTA GACAAGGGAA AATGTCTTTA AA - #ATGCAGAC4680- ATATAATCTT ATTTATTATT GTGTGTGAGT GTGGGTAGAC ACATGCCATG GC - #ATGCATGT4740- CAACTTTGTG GAGTTGCTTC TCTTTTTCTA CCTTTCCATG GATTCTGAGT CT - #CCAATTCA4800- GGTCACCACA CCTGTGGAGT TAATACCCTT ATCTGCTGGG CTGTCTCATC AG - #CGCCAAAG4860- AACTTGTTTT TAATACTGCC TGTGAATGAG ATGAATGGCA CTACTGAAAA AC - #TGTAAATT4920- AATATAAATT ATGCTGATCC CTGCTTAGCC TCAAATGAAT GAGACCCAAA CT - #ATAATTTA4980- TTTATTGGGC TCTGCTCAAT TACCTCGGGA TGACCCCAAA TCTATTCTCT AA - #TGCTAGTC5040- TGGCTACTTC CCCAACTGTG CTCCCCAAAT ACTTGCCGTC TGAATCTTCC TG - #GGTGATTC5100- CTGCTCTAGC AGCCTGGTGT CCCAGGAAGG CATTTCACTC AGGCAGTGCT GC - #TGGTCCAT5160- CAGGACTAAT GGAGATCTCC TCTTTTCTAT GTCTTCTTCC CCATTCCCAC CC - #CACCCTTG5220- TAATTGGTTG TTGCCAGTTT TACTTAACTA ATAGTTTTAA ATTGGATAAG TT - #TGCACAAC5280- AAAGGTGGGT TGTAACTAGG GATTTGCTTG TCTTGGCGCA ACCAGATCAT GG - #AGTACAGA5340- ATTTAACATA TGGATACAAG TAGCACCAGA CCAACCCACA ATAAAAAACA GA - #CAAAAAAA5400- AAAAAAAAAA AAAAAACCAG CAAAAAAAAC CCCCATAGAC AGTCTTTAAA TG - #ATAAGAGC5460- GGAAAAGTTG TAGGTGGTAA TAGATGGTTA GACAGGATAA TTTCAGGGAA GA - #TTTAAGTT5520- ATTTAAAAAA AATCTATTTA TATATGCATG CAATTGTGTG TGAGTGTGTG TG - #TGCGCACG5580- TGATTGTATG AGTATGTGAT GGCCAGTGCT CTTGGAGGTC AGGGTGTCAG AT - #CTGGTAGC5640- TGGAGTCTCA ACTTGGGTAG AAACTTTTAA CCTCTGAGCC ATCTTTCTAG CC - #CCAAGATA5700- CTGGTTTTGT AAATAAATTT ACCTTTAAAT TCTCTTCCTG GGGGGTATCT AG - #ATCCAATT5760- TTGTACGTAA GCAGATATTT CAAATTAAAA TGATGCTGGT GTCACACAGC TG - #CCGATTAG5820- TTACTGAGAT TTACGTTTGC TTCAACATTG TGCTGAACTA CATGCATAGC TT - #TTGTAAAA5880- GGTTATTTGC TGAAACTAGC TTTCTGGTAT TTCACCAGTA ATATACTCTG GG - #CACAGAAC5940- AAACTTGTTT TCTGACTCAA TATAAATATA TTGCGTGTGT GTGTGTGTGT GT - #GTGTGTGT6000- GTGTGTGTGT GTGTGTGTGC ATGTTATAAA ATCCTGTCTT CTGCTCATGA CA - #TAGCTGTT6060- TCATTAACTC ACAGCAGTTT GTATTTGCCT GCATGAGACC TATATAAGAT CA - #AGCCAGTC6120- TGAATCCCAG CATGCAAAGG GGAGATGCTA TCTGGGACCC ACCCTTCATG GG - #AGATACAG6180- GAATTGGTGG CTCCTGGGGG AGGGAAGAGT AATTTTTCTT TGGGAGTGTG GC - #CATTGTCA6240- TCTTGTCCAT GTTCCAGTGG ATAGCCCTAC ACTCATACAC AGAAGCAACA GT - #AACTGGAC6300- TTAGTGGGTT ATAAAAAATA TTAGAAATGG AATTTGTATA CAACCGAGCC GT - #ATCACTCC6360- TGATCATATA CCCAAAGGAC TTTACCATAC AATAGAAGTA TTTGCTTAGC CA - #TGTTTATT6420- GCTAATCTTT TCATAATAGT GAGTATGTGA ATAAGTGGAT GAGTGGATAG AG - #AGTCTGGA6480- ACTAGGTAGG AGACCATGAA CGGGAACAGT AGGTGTTGAG AAGGGGCAGG AG - #CAGAAAGC6540- AAAAGGTCAC ATTGGGCATT GTCTTAGTTA GGCTTACTAT CGTTGTGACA AA - #ACACAAAA6600- TAAAATCTCC AAAAGCAACT TGGGGAGGAA AAGATTAGAA TTTACGACTC TT - #GAGTTCAT6660- ACTCCATCAC TGTGGGAAGT CAGAGCAGGA ACTCTAGGCA GGAACTGAAG GA - #GAGGCCAA6720- GGAGGAACAC TGCTTACTGG CTTTCTCTTC ATGGCTTGCT CAGCCTGTTT TC - #TTAGACAC6780- CAAGAACAAC CTGCCCTGGG GTGACATCAC TTACTGTAGA CCAGGCCCTC CC - #ACATTAAT6840- CATGTGTCAA GAAAATGTCC CACATGCTTT CTTTAAGGCC AATCTTATAG AG - #CTGTGGGA6900- AGCCACATGT GCCGTTGCAG AGTGGCACCG GCTACTGCTG GCTACCACGC AT - #AAGTTTGG6960- ACAAACAACC AATGTGTACA TATGCAGTAA AGCTTTTTGC CAAGTCACTG CC - #TGGCCCCG7020- GCATGTTAAT GAGGTACTGA GAATATAACC AATCAGATGT GAGACATGCA AA - #TGAGGTAT7080- GATAATGAGG TTCTGTGAGG TACTGAGAGA GAGTAGCCAA TCAGATGAGG AA - #CATGCAAA7140- TGAGGCATAG TGCATAACCA ATCCGTGTGT GAGACACGCC TCTCCTAGGC CT - #ATATAAGC7200- AGCACCAGTT CTGGGCTCAG GGTCTCTTTG CCTCTGCAAT CAAGCTCTCC CA - #GAAGGATC7260- CTGTTGCAGC GTCGTTCTTG CTGGTCAAGT CGGGCGAGCA CAAAATAGAG CC - #TTTTTTTT7320- TTTTTAAATT GAGAGTCCCT CCTCCCAAAT GACTCCCGCT TGTGTCAGGT GG - #ACAGTAAA7380- CTAGCCAGGA CAGATGACCC CCTTGTCAAC TTGGCACACC AGTACTTATT AT - #GAAAACAT7440- AACCTTTCCC TTTTTGTTCA TTTTTAAGGT CTCATATTAA TATTATAATA TA - #AGCTATAA7500- ATAACTTTAA AAGTTTCATA TTCTTTAAAA ATTCAAAAAA TTTACAAGTT AA - #GTCTCTTT7560- AAAATATCCA AAATTTCTCT AAAATTACCA AGTTTCTTTG AAATATCCAA GG - #CCTCATAA7620- ATGGATGTTT CTGTAAAATT AAAATAAATT ACTTTCTTAT TCCAAGAGAG AA - #GAAGCAGG7680- GCACAGCCAC AGAAAATTCT GAGTGCACAT TAATAACTAA GTAAGATAAT GC - #CCCATAGG7740- GTTGTCTTCT GTCGGCCTGT CTTACAGAGG CAATTTCTCA ATTATGCTTC CC - #TTTTCTCA7800- GACAACACAT ACTTGTGTCA CATTGGCAAA AATCTAGCCA ACAAAGGCTT GA - #AAGCAGAA7860- GGCTACTGGG GATGGCAGGG CTCAAGGACT GGGGACTTGG TGATTAGGGA GA - #AATAGGGC7920- ATAGGAAGAG AAACCGCAAA AACAAAAATT TCTTGTAAAA ATGCTACAAT GA - #AACCTAAT7980- CATCTGTATA TAATAAAAAG TGAATAGAAC AGATTGTACA TCTGTAATTT GC - #TATCATCT8040- TTTGACTTCT GTTAGTGGTT TTGAAATCTT GGCAAAAAGC AACTTAACCA TT - #AACAGTTC8100- TAAATTGCTT TAGGGTTTAT AAAACCTGCA TTTTCACATG AGATTGTCTT AT - #TACATTAA8160- AGTTGGGTGG ATCTGGGAAG AGTTACACTA TGTATGCAAT TCTCAAAGAA CC - #GAGGAAAG8220- GAAGATAAAA TTTCTTTATA TTATTTAATA GTGCTGAGTG TAGTAGGCTG TT - #CCTCCATC8280- TTAAATGCGT GCTCTGATTT CTTCATGGTA ACAGAGGTTT CATCAGGAGA CT - #CTTCCAAA8340- ACATATTTAA AACTTTACTC CCCACAAGAC ATTTGGGTAA CAGGAACTTT CC - #GGANGTGT8400- GAGGAGTTTA TTACTTGGCT TTAGTATAAA TCATGTAGGA GCATGGATGC AT - #TTCATTAT8460- TGAAAAAATA ATATATTTGG AGTCTCATAC TTGAAGTCTG GGTTATATTC CA - #GAGAGCCC8520- TCAAAACTAG TAACAGCTTA AGAGAAAGAT CATCCAAGAA ACCCTTTCTT TT - #TAGGGAAG8580- TGTCTCTTAC TCAGCCAAGA GCACAGTGAA AGGGCTTAGT ATTGGACAGC TA - #TTATATCT8640- TCAAAACTAG GTCTTTATTT TATTTTACGA ATAAATCCAG TAGTTGCTCT GA - #GTCAGCTT8700- ATACCTTATG AGAGATGATA ATTATACAGA AAATCAAAGA TGCTGAAAAT GT - #AATACCTC8760- ACATACTGAG GGATCCTGTT CATTAAGGAG ATAAAAATTA TTCTTTTGAA GG - #AGCAAAGC8820- TATACACATA ACATATTAGA ATTTTGAAAC AGCCACAATC ATAGAACTTA AT - #TTGTTATA8880- AAAGGAAGAA GTAATGTATA GTTAATAAGT GGTTTAAGCC TTGTCCTTGA GG - #CTAGATGT8940- TATAACTCAT ACTAAATATG TATGTTTGTT TCAGGCTAGG TATCATATCC TA - #CACGAAAT9000- ATGTATGTAT GTTTCAGGTT AGATGCTATA TCCTACACTA ATTATATATG TT - #TGTTTCAT9060- TTTCAGTCCT ATCTATGGAG CTGTCTCTGA GCTTTCTATC AAATATTTGT CA - #TATTTATT9120- CATAGATATT GTTTATTGGA ATTTGCAAAC AGGGCATTTT AAAGACAAAT GA - #AAATAAAA9180- TGGAAACCAC TTCACTACAG CGGAAATTTC CAGAATGGAT GTCTATGCAG AG - #TCAAAGAT9240- GTGCTACAGA AGAAAAGGTA ATTGTTCATT GATTATTTGT CTAAATGGGC AA - #TCTTGTTT9300- GAGTTTGACT ATGCAGTGAG TCACATCATT GCTTGTGAGC TTTGGGTCAT TG - #TTGAGGTA9360- AAACTTTCTG TTGTGTGAAT GAACCAGAAC TAAGTTGTTC AAAGGTAAAT GA - #GACTCAAT9420- TTTATACATG TTTTATAAAA TGAGATTCCC TAGAGTATAT TCTTTCTTTT TA - #TAGTTAGC9480- ATTCTTAGTT GAAGTTATTG GTTTGTTCAA ATTCAAGTAA TAATTTATAC AA - #TATTAATG9540- TTGGCATTTT TTGGTTAAAA TAGTTTGAGT CCTTAGAGGC TTAAGATCTG AT - #AATTAGCC9600- ACCAACATTT TTTTGTTTTC TTTTTCAATA TTTTATTAGA TATTTTCTTC AT - #TTACGTTT9660- CAAATGCTAT CCCGAAAGTC CCTTATACTC CCTCACTCCA CCCACTCCCC TA - #CCCACCCA9720- CTCCCACTTC TTGGCCCTGG CGTTTCCCTG TACTGGGGCA TATAAAGTTT GC - #AAGACCAA9780- GGGGCCTCTC TTCCCAATGA TGGCTGACTA GGACATCTTC TGCTACATAT GC - #ATCTAGAG9840- ACATGAGCTC TGGGGGGTAC TGGTTAGTTC ATATTGTTGT TCTACCTATA GG - #GTTGCAGA9900- TCCCCCCAGC TCCTTGGGTA CTTTCTCTAG CTCCTCCATT GGGGGCCCTG TG - #ATCCATCC9960- TATAGATGAC TGTGAGCATC CACGTCTGTG TTTGCCAGGC ACTGGCATAG CC - #TCACACGA10020- GACAGCTATA TCAGGGTCCT TTCAGCAAAA TCTTGCTGGC ATGTGCAATA GT - #GTCTGCGT10080- TTGGTAGCCA CCAACATTTT AAGGTTACAT TATTGCATCT AGCATGCTAA TA - #TAATTATG10140- AGGAAAAAAC AAGTAAATTA AGTGACTTCA CAAAAGAAAG ATTGGATGTT TG - #AAAATAGA10200- ATTGTGTGGA AAAATAACTT TATGTTTACC CTTGTTAATC TGACCTTATG AA - #TTCTTACT10260- CTATAATATA AAATGTAGTG CTATAAATTT CTTCAGTGAA CTTTATTATT TC - #AGTTAACA10320- CTACAACTTA CTGTGATATT TATTTGTGCC TGTTTTGAAT TTTGCTCAAC TC - #AAGGCCTG10380- CGTTCAGAAG AGTGTTCTTG AAGATAATCT CCCATTCTTA GAATTCCCTG GA - #TCCATTGT10440- TTACAGTTAT GAAGCTAGTG ATTGCTCCTT CCTGTCTGAA GACATTAGGT AA - #GGGATTGG10500- AAGTTCTTAC CATTAAGTTT GTACCCGTAA GAAATAGCGA TATTTATGAG TG - #CCTAGTTT10560- TACAATGGAA GTATATCTCA GAAGTATATT TACATACATC ATATCACAGT TG - #TATTCTAC10620- TTTTTAAAAT ATAAAATAAA CTCACTAAAT TAAATTAGTA AGGTTCCTAT TT - #GTTAATTA10680- GTAACCTTTT CTACTTTATT AGATACTTTT TTTTTCTTTT AGTGCTTTAG AT - #GTAAATAC10740- AGGTAAAACT ATTGAAGACA ACTGTTTACC AATTTAGGAA AAAATGGAAA AT - #GTTATTTA10800- ATGTCGAACT ATTTTCATAT CTTAAAACAT CAATGTATTA AGTAATGTTT AT - #GATTCTCT10860- GTTTTATTTT TTTTAATTTA TTTTTAGCTT TTAAAATTGT GTTAGGATGC CT - #CCTCTGCG10920- TGTATGTTTG TATACCACAT GGTTACGGTG TCCACAGAGG CCAGGAGAGG GC - #TTTGGATC10980- CCCTTGAACT GGAGTTGTGA GCGATCTTAT GGGTGCCGGG AATCAAGCCT AG - #GTTCTCTG11040- GAAGAGCAGC CAGTGCATTC AGCTGCTGAA CCATTTTAAA AGATAGTGAT AG - #TTCCTGCA11100- AATGGTCCAT GAAAAGAGCT TTAGCAATGA CTGTTGGTAC TTTAAGAGTT GC - #CTGTCTTT11160- GTTTTTCTAA GGCTATAACA AAATCCATGG CCTGAGTAAA TTATAAAAAA AT - #ACATATAA11220- GTAAATTCAT AAATAAATTT ATTCCTTACA GTTTTGGAGG CTATAGAGCC CC - #CAGAGAAT11280- GGGATTGGCA TTTGTAAGGG GACCATTTTT TTTTTTAAAT TGGATATTTT CT - #TTATTTAC11340- ATTTCAAATG TTATCATCTT TTCTGGTTTC CTTCCCTCCT GGAAACCCCC TA - #TCACATCC11400- TCCGTCTCTC TGCTTCTGTA AGAGTGTTCC TCTACCCACC CACCCACCCA CC - #CACCCACT11460- CCCACCTTCC TGCCCTTGAT TCACCTACAC TGATGCATCT ATTGAGCCTT CA - #TAGGACCA11520- CGGACATCTC CTCCCACTGA TGAATGACAA GGCCATCCTC TGCAACATAT GC - #AGCTGGAG11580- CTATGTGTAC TCCTTGGTTG ATGGCTTAGT CCCTAGTTTT CTGGGGGTGG GG - #GAGGTGTG11640- ATCTGGTTGG TTTATGTTGT TGTTCTTCCT ATGGGATTTC AAACCCTTTC AA - #CTCTTTCA11700- GTCCCTTCTC TAACTCCTCT ATTAAGGACC CTGCGCTCAG TCCAATGGTT GG - #CTGTTAAC11760- ATCCACCTCT GTATTTGTAA GGCTCTGGCA GGGCCTCTCA GGAGCAGGCT CC - #TTTCAGCA11820- TGCACTTCTT GGCATCCACA ATAGTGTCTG GGTTTGGTAA CTGTATATGG AA - #TGAATCCC11880- CAGGTGAGAC AGTTTCTGGG TGGTCTTTCC TTCAGTCTCT GCTCTTCACT TT - #ATCTCCAT11940- ATTTGCTCCT GTGAGTATTT TGTTCTCCTT CTAAGAAGGA CCGAAGCACC CC - #CACTTTGG12000- TCTTCTTTCT TATTGACCTT CATGTAGTCT GTGAATTGTA TCCTGGTCAT TT - #GGAGCTTT12060- TGGGCTAATA TCCACTTATC AATGAGTGTA TAATATTTGT GTTCTTCTGC GA - #TTGGGTTA12120- CCTCACTCAG GATGATATTT TCTGTCCATT TGCCTAAGAA TTTCATGAAT TC - #ATCATTTT12180- TAATAGCTGA GTAGTAAGTA CTCCATTGTG TAAATGTACC ACATTTTCTG TA - #TCTATTCC12240- TCTTTTGAAG GACATCTGGC TTCCTTCCAG CTCCTGGCTA TTATAAATAA AT - #ATATAAAC12300- ATAGTGGAGC ATGTGTTCTT ATTACATATT GGAACAGAAA GAGCAATTTG CA - #AATTCATT12360- TGGAATAACA AAAAAAAAAA AAAAAAAAAC CCAGGATAGC GAAAACTATT CT - #CAACAATA12420- GAAGAACTTC TGGGGGAATC ACCATCCTGA CCTCAAGTTG TATTACAGAG CA - #ATAGTGAT12480- AAAGACTGCT TGGTAATGGT TCAGAGACAG GCAGGAAGAT CAATGGAATA GA - #ATTGAAGA12540- CCCAGAAATG AACCCACACT CATATGGTCA CTTAATCTTT GACAAAGGAG CT - #AAAACCAT12600- CCAGTGGAAA AATGACAGCA TTTTTAACAA ATGGTGTTAG TTTAACTGGT AG - #TCAGCATG12660- TAGAAGAATG CAAATCGACC CATTTTTTTC TTTTCTTTTC TTTATTTACA TT - #TCAAATGT12720- TATTCCCTTT CCTGGTTTCC CCTCTAACCC CCCCCCCCCC CCACACACAC AC - #ACACACAC12780- ACCAACCCAC TGGCTTCCTC TTCCTGGCCC TGGCATTCCT CTATACTGGG GC - #ATAGAGCC12840- TTCAAAAGAC CAAGGGCCTC TCCTCCCATT GATGACCAAC TAGGCCATCC TC - #AGCTACAT12900- ATGTAGCTGA AGCCATGAGT GTGCTCTTTG GTTAGTGGTT TAGTCTCTGA GA - #GCTCTGGT12960- GGTACTGGTT AGTTCATATT GTTGTTCCTC CAATGGGGCT GCAAACCTCT GC - #TACTCCTT13020- GGTTACTTTC TCTAACTCCT TCACTGGGGA TCCTGTGCTC AGTCCAATGG AT - #GGCTGTGA13080- GCATCCATTT CTGTATTTGA AGTTGACCCA TTCTTACCTC CTTGTACAAA GC - #TCAAGTCC13140- AAGTGGATCA AGGACCTTCA CATAAAACCA GATACACTGA AACTTATAGA GA - #AGAAAGTG13200- GGGAAGAGCC CCAAACATAT GGGCACAGGG GAAAAATTCC TGAACAGAAC AC - #CAATGGCT13260- TATGCTGTAA GATAAAGAAT CAACAAATGG GACCTCATAA AATTGCAAAG CT - #TCTGTAAG13320- GCAAAGCACA TTGTCAATAA GAAAAAAAGG CCACCAACAG ATTGGGAAAA GA - #TCTTTACC13380- AATCCTACAT CTGATAGAGG GCTAATATCC AATATATTCA AAGAACTCAA GA - #AGTTAGAC13440- TTCAGAGAAC CAAATAACCC TATTAAAAAT GGGGTTCAGA GCTGTCTTAG TC - #AGGGTTTC13500- TATTCCTGCA CAAACATCAT GACCAAGAAG CAAGTTGGGG AGGAAAGGGT TT - #ATTCGGCT13560- TACATTTCCA TATTGCTGTT GATCACCAAA GGATGCAGGA CTGGAACTCA AG - #CAGGTCAG13620- AAAGCAGGAG CTGATGCAGA GACCATGGAG GGATGTTCTT TACTGGCTTG CT - #TCCCCTGG13680- CTTGCTCAGC CTGCTCTCTT ATAGAACCCA AGACTACCAG CCCAGAGATG GT - #TCCACCTA13740- CAAGGGGCCT TTCCCCCTTT ATCACTAATT GAGAAAATGC CTTAGAGTTG GA - #TCTCATGG13800- AGGCATTTCC TCAACTGAAG CTCCTTTCTC TGTGATAACC CCAGCTGTGT CA - #AGTTGACA13860- CAAAACCAGC CAGTACAAGA GCTAAACAAA GAATTTTCAA CTGAGGAATA CT - #GAATGGCT13920- GAGAAGCACC TAAAGAAATG TTCAACATCC TTAATGATCA GGGAAATGCA AA - #TCAAAACA13980- ACCATGAGAT TCCACCTCAC ACCAGTCAGA ATGGCTAAGA TCAAAAACTC AG - #GTGACAGC14040- AGATGCTGGC AAGGATGTGG AGAAAGAGGA ACACTCCTCC ATTGCTGGTG GG - #ATTGCAGG14100- CTTGTACAAC CACTCTGGAA ATCAGTCTGG CGGTTCCTCA GAAAACTGAA CA - #TAGTACCT14160- ACTACCTGAG GACCCAGCTA TACCACTCCT GGGCATATAT CCAGAAGATG CT - #GCAACATC14220- TAAGGGAACT TTGTACTGCG TCTGTATCAG GGTAGAGGCT AAGATGGGTT GG - #GATTAAGC14280- CAGTTCTCTG GATACCTGTT CTGGGAGTGG AGCCCTGATG AGCCAAACAC TT - #GTGTTTAG14340- GCCCCACCTC CACGCCCTGC TCCATTAAGG ATTCCATTTT AACAGGGACT AT - #GAATAGGA14400- TATTCATGAC CCAGCACCTT GTGTAATTCG GGTTCTGGAG TAATGCAATC TA - #AGCCTCTT14460- GATGCAACTT ACACTGAGAA GTAGTAAATC AATTCAGATC ATTGAAATGA CT - #GCGTGTGT14520- CCTTTTGGTT TTTAACTATT TTCATGAAAA GCAGAAGTGA ATAAAGTTGT TC - #ATCAGTGC14580- CCTCCTGGTG GTTGGTAAAT GTGATCTAGA AGTGGCATTT AGGTATCTTT AC - #TTCCACTG14640- CATTTACTGG TTATGTGTGG GCTTCATTTT GCTGAACTAA AATTAGACTT AC - #AGAATAAG14700- TAAATCTATT ACACACGGTT ATATATTGTC CTCACCATGT TACCTTTGTC TT - #CCTACGGT14760- ATGACATGTG TTTTATTAGT CAGAGGGTTT TTTTTTTTTG GTTTGTTTGT TT - #ATCTTTTG14820- TTTTTAAAGG AATAGAACTG GCAGAATGAA CGTATATATA TATCAAACAG GG - #ATTTATTA14880- GTGTGGCTTT GCAGACTGAG GTCTCTTGTC CAACAATGGC TGTGCCTCAT CA - #AAGCCAAG14940- AATCCTTTTT TCTCGTAGTT GTTCATTCGA GGAGCCTGGG TGTCTAAGTC AG - #TCTTCAGT15000- CTGCATGGGC TTCCTGAAGA AGGAATTTCT AACACCAGCT AAGTAGTGCC TT - #AGTAGCAA15060- GACAGACGAA CTTGCCAGCC AGACTGAGGA CAGGCTGACA AAAAGCCAAA GC - #TTCCCTCT15120- TCCGTGCCCC TTCAGAAGTG GGCCGCCATC AGAAAGCGTA ACCTAGATTT AG - #GATGCTCT15180- TCTCCTGTCA CATAATCTAA TCAAGAAAAG CCCTCATAGG TGAGCCCAGG GC - #TTATATTT15240- TAGATGATTC CAAATGGAGT CAGGTTGCCA GCCAAGATCA GCTCAGCACA GT - #AAGTTGAA15300- GTGGTCTGAA TGAAGCTCTG TGTTCATTTT GAAGTGCAAG ACGGGCTTGG TT - #TGCTTTGC15360- ATTACTTTTC ATATGGCCAC TTTGGAGATC CTCGCATCAG GGGCTGGAAA CA - #TGGCCCCC15420- CATTAAGAGC AGGAAGCGCT ATTGCAGAGG ACCCCAGTCT GGTTCCCAGT AC - #CCATAATG15480- GTGGCTCACA GACCTCTGTT TTCTATGACT CCAGCTCCAG GGTGCTGAGT CC - #CTCTTCTG15540- CCCTCTACAG GCACCTGTGC TTATGTGCAC ATATGTACCC CTCTTCCCAT AC - #ACACCTGG15600- TTAGAAAAAT AAAAATCTTA AAGAATATTT TTACACCAGG GCCAGTGACA TG - #GCTCAGCG15660- GGTAACAGGG CCTGCCACCA AGACTGGAGA TCTGAGTTCT AATCCCATTT CA - #ACCTCAGA15720- GGCTCATGGT GGAAGCCAAG AGCTGATCCT GAATTCAACA TGCATGGGGC CA - #CCAAAAAA15780- GAAAGAAAGA AAGAAAGCAA TTTAAAAAGA TGTTTACCCC ATGGGGTTTC AA - #CAGTTTGA15840- TATGACATAC CTTTGTGTGC TGAAGTTTGT GCTGATCCTG CTTGGGGACC AT - #CGACCTTT15900- TTTTTTTTTT TTTTTAAATT TGTGGGTTTA ATAGTTTTTG TCCAATTTGA AA - #ATCATCTT15960- CAGTTTTTAT TTTTTTCAGT ACTGTGCTTT TCTGGGACTC TGATATACAT AC - #ACTAGGTT16020- GCTGGATACT ATGTCTTAAC TTCTTTTCTC TTTTTGTTTA TGCTTTGGTT TG - #AATGTTTC16080- TTCTGCTGTG TCTTTAAGTT AATCACCTAT ATTTCTTCTG TAGTGGCTGA TC - #TACTGTAT16140- ATCCTCCCTG TGTATTTTTA ATTTTCATTG TGTTTTTCTC TTTTTTGTTA TT - #GAAAATGA16200- TTTTTTTAAA AATACAACAC ATTTGGACTG TGGTTTCCCT TTCCACAACT CA - #CCCCAAAT16260- CCTCTCCACC TCAACAGAAA AAGAAAGGGC CAGAGAAGAA GCACAGGAAA CA - #CATACAGA16320- TGCAGGCCAC ACACGTGTAC ACACAGGAAT CTCATAAGTA CACAAAATCA GA - #AACCAGAT16380- ATATAAAAAT TATATAAGCA AAAGACTTGC TAGATTAACA AAATAAAGGT TC - #ATTCTCTG16440- TTGGCCATTT ACTGCTGGGC CTAGGGCCTG CTGGTGAGTG TGGTTTGTAT AC - #CCAGTGAG16500- TCTGGTGGAG AAACTAGTTT TTCCTTTGTG AGTGGTTATA AATAGGAGAT AA - #TTTCTGGG16560- TGAGGGATAG GATCGGCGCT GGGACTTTAT CTGGTTAGAC CTGGGTAGAC CC - #TGTGTGTG16620- CTCCCACATG AAAGCTCTTC TGTGCTTTAT CAGCCCTGCT GTGTCTTGAA GG - #GCTTCTTG16680- CCTTGGTGTC TTCCATCCCA CTGGGTCTTA CAACCTCTCT GCCCCCTCTT TT - #GCAAAGTT16740- CCCTGAGCCA TGCGGGGAGG GGTCTGTCAT TGTTCCCATC TCCTGCAGGA GG - #CAGTGTCT16800- CTGACATTGG CTGGGCAAGA CACTGAGCCA TGAGCATAAA AAAACCCTGC CA - #ATTTGCTA16860- TTCATTGTGT GCATGCTTTC CTTTAAATTC CTGAACATAT TTACAATTTA TA - #ATAGTTTT16920- CGTTTGTCTT GTTTTGAGCA GGGGCTTATG TAGCCTAGGC TGGCCTTGAA TG - #TACTCTGT16980- CGCCAAGGCT GATCTTAGTT CCTGATCCTA TTGCCTATGC CACCAAGTGC TG - #GGATCACT17040- GACTTGTGCC AGCAGGCCCT GCTGTGACCA TAATGCAAAT TTCAGTGATA TT - #TTAGCTCT17100- ATTTTTGCCT CTATTGAGTG ATCACCCCGC CAACTGATTA TGTTTATGTT TG - #ATATGTGT17160- CAGGGCTGTT GAGGTTTTTT TTCTTTTTCT TTTTTTTTTT TTTTTTTTGG TC - #TGCTGTTG17220- TGATTTTACC TTGCTCAATA TATATATATA TATATATATA TATATATATT TT - #TTTTTTTT17280- TAGTTTGCTT TCTAAGAAAA GAGGTTTTGC CAGAGGGCTC ACCCAGAGAT GG - #GTTTTGTA17340- TTCGGAGGCT TGCTTTTAGA CCTCATTAGG CCGGCAATTG CTTTTCCTCC AA - #AGGTAATT17400- TAGTTCTCTC AGGTGCGATC ATAAGGGAGG CTGCTGCATG TTCCTAGAGT TC - #AGCAAGAA17460- TGTCTGCTGG GACTTGGGAA CTTACGCTCT TACCTCTGTC TGTGTCCCCA CC - #TCAGGGCT17520- GTCCTTTCTC TGTTGTCTGT AAGGCATTCT AGGAGAACCA GGGACAACGA CA - #GAGACTGT17580- CCTCTTGTTC AGAGAACAGT AAATTTAGAC GTGTTTGTAC AATTTATTGT TT - #CTTTTTAG17640- TGGAAAAAGA AGTACTTGTA AATTTTATCT TAGCCTGAGG TATTAGTTGA TA - #TTCTTTTA17700- TGTTTGTAAT AAATTTTTAA TCAAAACTTG TGAACTAGGC ATAGAAACAA TA - #GTAAACAA17760- AACCGTATCT TCTTATTTAA TTATATCAAA TCTTTATTAT TTAGTGTGTA TG - #TGTGTGTG17820- CTCATGTATG TAGATATATA CTTGGTCAGA GGACAACTTT CAGGAGTAGT TT - #TCTTCTAT17880- TATTTATGTC TAAAATTAAA TAGAAAATAA AAGCTCATGT ATACCCTTTT TA - #ATTTATTT17940- TCTTCCAACC CCCGTGCTAC TTTAAATAAC ATGTCATGAA TTTAGTATTT AT - #CATTTCTT18000- TATATTGTGT TATTTGCCAA CTTAGAAACT ATATGGTTTT CCTGAAGCTT GT - #CTTTTTCA18060- CTCAAGTTTT GAGAATTTTT CATTTTGATA TATGTAGTTC CATTATTTTA TA - #TGCTATAT18120- TATGTTTTGG CATGCCACAA TTTCTTTATT TTTTTGTTTT ATGGAAACAT AG - #TTTTTCCA18180- ATTCCCCCGT CTGCAAAAGG ATCAGGGTTG TAGTGAACAT TCTTTCTTTG CT - #GTGTTGGT18240- TAGTGTTTCT TGTCCATTTG GCACAGCCTA GAGTCGTCTG AGGCTAAGGA AC - #CCAACTGA18300- GAGAATGCCC CATCAGATTG GTGTATAGGC AAGCGTGGGA ATAGGGTTTT CT - #TGACTGAT18360- GATTGATGTG GGAGGGACCA GCTCACCTTG GGCAATGTCA TCCCTTGGGA GT - #TGGTCCTA18420- CCTTGTATAA GAAAGCAAAC CTAGCAAGCC AGTTAGCAGT GTTTCTCCAT GG - #CCTCTACT18480- TCCGCTCCTG CTTCTAGGGA CCTGCCTTGA GTTCCTGCCC TGACTTCCTT TT - #CTTCCCAA18540- ATTGCTTTTG GACATGGTGA TGATCACAGC AATAGATGGC AAACTAAGAC AT - #TAATCAAT18600- TGAGCTGTCT CACCTTTTAG AGTGGTTTGA ATAAGCATGG CCCTCAAAGG CT - #CATATATA18660- GAATGGCTAA TCACCGAGGA GTGGAACTCT TTGATAGGAT TGGAACAGTG GT - #TCTCAACT18720- TGAGAGTCTT GATGTCTTTG GACATTAAGC GACCCTTTCA CAGATATCCT GA - #ATATCAGG18780- TATTTACATC GTGATTCATA GCAGTAACAA AATTACAGTT ATGAAGTACC AA - #TGAAATCA18840- TTTTATGGTT GGCGTCATTA GGAAGGTTGA CAACCACTGG ATTAGAAGAA TT - #AGGACTTA18900- TGACCTTGTT GGGGGAAGTG TGTCACTTGG GGTGGGCTTT GAGGCTTCAA AA - #GCCTAGAC18960- TTTGAACAGA CCTTTTGCAC AAGAACAGGC CTCTTGTTCT CTCTACTGCT GC - #TCAGGGTA19020- TAGCTCTCAG CTGCTGCCGC AGTGCCGTGC TTTACACCAT GATAATGGAC TA - #AGCCTCTG19080- AGCTGTAAGC CAGCCACCAA TTACATGCTT TCTTTTATGA GAGTTGCCAT GG - #TCATGGTG19140- TCTCTGCAGC AGTACAACAG TGACTAAGAC AGAAGGAAAC ATAGAAACAT TC - #ACGCAGTT19200- AATCCACACA ATTTTTCCTT TGATAGCATG CGTCTGTCTG ATGGCGATGT GG - #TGGGATTT19260- GACATGGAAT GGCCGCCCAT ATACAAGCCA GGGAAACGAA GCAGAGTCGC AG - #TGATCCAG19320- TTGTGTGTGT CTGAGAACAA ATGTTACTTG TTTCACATTT CTTCCATGTC AG - #GTTGGTAT19380- CTCTGCTTCA TTGTCATATG GCCATCAATA ATACCATATC AACTTTCTTC CT - #GCAAAGTT19440- AAGTTCTTTC ATTAGCAGGC CTTCTTTCAT GATCTTGTAT TTGTTTAAGT AT - #TTATATTT19500- TTACTTGATT TTTATACCTT TTCCCTTGGT TAGAGAATAG AGAACTGAAG TT - #TAGAGGTG19560- TAAATGACTA GGAATAATAC CCTATTACTG TTACTACAGG TGGCGTTCGA AC - #TCATTCTA19620- TCTAGTCAAA TTTCAGTCTG GACTCTGCAT TAGCTAAGAA AAGAGATAGT TA - #AGGTGAAT19680- GTGATTCTAA ATTTAAGCTT AATATAAACA GTTTACCACA CATTCCGTGT GC - #ATTAAAAT19740- AGTAAATCCA TTATATTAAA GAGTTTTATG GAAATAATAA TGAAATGTTT TA - #GTTTTCCC19800- CCAGGGATTA AAAATGTTAC TAGAAAACAA ATCAATTAAG AAGGCAGGGG TT - #GGGATTGA19860- AGGGGACCAG TGGAAACTTC TGCGTGATTT TGACGTCAAG TTGGAGAGTT TT - #GTGGAGCT19920- GACGGATGTT GCCAATGAAA AGGTAGGCGT AATAAATGCA GTATTTTAAT AA - #ACATGATA19980- ACCTGAGTTT CATAGAATGT GCATTTTCAT CTAAATGTTA AGTTTCTTTT TT - #TTTCCATT20040- TTTTATTAGG TATTTAGCTC ATTTACATTT CCAATGCTAT ACCAAAAGTC CC - #CCATACCC20100- ACCCACCCCC ACTCCCCTGC CCACCCACTC CCCCTTTTTG GCCCTGGCGT TA - #CCCTGTAC20160- TGGGGCATAT AAAGTTTGCA AGTCCAATGG GCCTCTCTTT CCAGTGATGG CC - #GACTAGGC20220- CATCTTTTGA TATATATGCA GCTAGAGTCA AGAGCTCCGG GGTACTGGTT AG - #TTCATAAT20280- GTTGTTCCAC CTATAGGGTT GCAGATCCCT TTAGCTCCTT GGCTACTTTC TC - #TAGCTCCT20340- CCATTGGGAG CCCTATGATC CATCCATTAG CTGACTGTGA GCATCCACTT CT - #GTGTTTGC20400- TAGGCCCCGG CATAGTCTCA CAAGAGACAG CTACATCTGG GTCCTTTCAA TA - #AAATCTTG20460- CTAGTGTATG CAATGGTGTC AGCGTTTGGA TGCTGATTAT GGGGTGGATC CC - #TGGATATG20520- GCAGTCTCTA CATGGTCCAT CCTTTCATCT CAGCTCCAAA CTTTGTCTCT GT - #AACTCCTT20580- CCATGGGTGT TTTGTTCCCA AATCTAAGGA AGGGCATAGT GTTCACACTT CA - #GTCTTCAT20640- TCTTCTTGAG TTTCATGTGT TTAGCAAATT ATATCTTATA TCTTGGGTAT CC - #TAGGTTTG20700- GGGCTAATAT CCACTTATCA GTGAGTACAT ATTGTGTGAG TTTCTTTGTG AA - #TGTGTTAC20760- CTCACTCAGG ATGATGCCCT CCAGGTCCAT CCATTTGGCT AGGAATTTCA TA - #AATTCATT20820- CTTTTTAATA GCTGAGTAGT ACTCCATTGT GTAGATGTAC CACATTTTCT GT - #ATCCATTC20880- CTCTGTTGAG GGGCATCTAG GTTCTTTCCA GCTTCTGGCT ATTATAAATA AG - #GCTGCTAT20940- GAACATAGTG GAGCATGTGT CCTTCTTACC AGTTGGGGCA TCTTCTGGAT AT - #ATGCCCAG21000- GAGAGGTATT GCTGGATCCT CCGGTAGTAA ATATGTCCAA TTTTCTGAGG AA - #CCGCCAGA21060- CTGATTTCCA GAGTGGTTGT ACAAGCCTGC AATCCCACCA ACAATGGAGG AG - #TGTTCCTC21120- TTTCTCCACA TCCACGCCAG CATCTGCTGT CACCTGAATT TTTGATCTTA GC - #CATTCTGA21180- CTGGTGTGAG GTGGAATCTC AGGGTTGTTT TGATTTGCAT TTCCCTGATG AT - #TAAGGATG21240- TTGAACATTT TTTCAGGTGT TTCTCTGCCA TTCGGTATTC CTCAGGTGAG AA - #TTCTTTGT21300- TCAGTTCTGA GCCCCATTTT TTAATGGGGT TATTTGATTT TCTGAAGTCC AC - #CTTCTTGA21360- GTTCTTTATA TATGTTGGAT ATTAGTCCCC TATCTGATTT AGGATAGGTA AA - #GATCCTTT21420- CCCAATCTGT TGGTGGTCTT TTTGTCTTAT TGACGGTGTC TTTTGCCTTG CA - #GAAACTTT21480- GGAGTTTCAT TAGGTCCCAT TTGTCAATTC TCGATCTTAC AGCACAAGCC AT - #TGCTGTTC21540- TGTTCAGGAA TTTTTCCCCT GTGCCCATAT CTTCAAGGCT TTTCCCCACT TT - #CTCCTCTA21600- TAAGTTTCAG TGTCTCTGGT TTTATGTGAA GATCCTTGAT CCACTTAGAT TT - #GACCTTAG21660- TACAAGGAGA TAAGTATGGA TCGATTCGCA TTCTTCTACA CGATAACAAC CA - #GTTGTGCC21720- AGCACCAATT GTTGAAAATG CTGTCTTTCT TCCACTGGAT GGTTTTAGCT CC - #CTTGTCGA21780- AGATCAAGTG ACCATAGGTG TGTGGGTTCA TTTCTGGGTC TTCAATTCTA TT - #CCATTGGT21840- CTACTTGTCT GTCTCTATAC CAGTACCATG CAGTTTTTAT CACAATTGCT CT - #GTAGTAAA21900- GCTTTAGGTC TGGCATGGTG ATTCCGCCAG AAGTTCTTTT ATCCTTGAGA AG - #ACTTTTTG21960- CTATCCTAGG TTTTTTGTTA TTCCAGACAA ATTTGCAAAT TGCTCCTTCC AA - #TTCGTTGA22020- AGAATTGAGT TGGAATTTTG ATGGGGATTG CATTGAATCT GTAGATTGCT TT - #TGGCAAGA22080- TAGCCATTTT TACAATGTTA ATCCTGCCAA TCCATGAGCA TGGGAGATCT TT - #CCATCTTC22140- TGAGATCTTC CTTAATTTCT TTCTTCAGAG ATTTGAAGTT TTTATCATAC AG - #ATCTTTCA22200- CTTCCTTAGT TAGAGTCACG CCAAGATATT TTATATTATT TGTGACTATT GA - #GAAGGGTG22260- TTGTTTCCCT AATTTCTTTC TCAGCCTGTT TATTCTTTGT ATAGAGAAAG GC - #CATTGACT22320- TGTTTGAGTT TATTTTATAT CCAGCTACTT CACCGAAGCT GTTTATCAGG TT - #TAGGAGTT22380- CTCTGGTAGA ATTTTTAGGG TCACTTATAT ATACTATCAT ATCATCTGCA AA - #AAGTGATA22440- TTTTGACTTC CTCTTTTCCA ATTTGTATCC CCTTGATCTC CTTTTCTTGT CG - #AATTGCTC22500- TGGCTAATAC TTCAAGTACT ATGTTGAAAA GGTAGGGAGA AAGTGGGCAG CC - #TTGTCTAG22560- TCCCTGATTT TAGTGGGATT GCTTCCAGCT TCTCTCCATT TACTTTGATG TT - #GGCTACTG22620- GTTTGCTGTA GATTGCTTTT ATCATGTTTA GGTATGGGCC TTGAATTCCT GA - #TCTTTCCA22680- ACACTTTTAT CATGAATGGG TGTTGGATCT TGTCAAATGC TTTTTCTGCA TC - #TAACGAGA22740- TGATCATGTG GTTTTTGTCT TTGAGTTTGT TTATATAATG GATTACATTG AT - #GGATTTTC22800- GTATATTAAA CCATCCCTGC ATCCCTGGAA TAAAACCTAC TTGGTCAGGA TG - #GATGATTG22860- CTTTAATGTG TTCTTGGATT CGGTTAGCGA GAATTTTATT GAGGATTTTT GC - #ATCGATAT22920- TCATAAGAGA AATTGGTCTG AAGTTCTCTA TCTTTGTTGG GTCTTTCTGT GG - #TTTAGGTA22980- TCAGAGTAAT AGTGGCTTCA TAAAATGAGT TGGGTAGAGT ACCTTCTACT TC - #TATTTTGT23040- GAAATAGTTT GTGCAGAAGT GGAATTAGAT CTTCTTTGAA GGTCTGATAG AA - #CTCTGCAC23100- TAAACCCATC TGGTCCTGGG CTTTTTTTGG TTGGGAGACT ATTAATAACT GC - #TTCTATTT23160- CTTTAGGTGA TATGGGACTG TTTAGATAGT CAACTTGATC CTGATTCAAC TT - #TGGTACCT23220- GGTATCTTTC CAGAAATTTG TCCATTTCGT CCAGGTTTAC CAGTTTTGTT GA - #GTATAGCC23280- TTTTGTAGAA GGATCTGATG GTGTTTTGGA TTTCTTCAGG ATCTGTTGTT AT - #GTCTCCCT23340- TTTCATTTCT GATTTTGTTA ATTAGGATTT TGTCCCTGTG CCCTCTAGTG AG - #TCTAGCTA23400- AGGGTTTATC TATCTTGTTG ATTTTCTCAA AGAACCAGCT CCTCGTTTGG TT - #AATTCTTT23460- GAATAGTTCT TCTTGTTTCC ACTTGGTTGA TTTCACCCCT GAGTTTGATT AT - #TTCCTGCC23520- GTCTACTCCT CTTGGGTGAA TTTGCTTCCT TTTTTTCTAG AGCTTTTAGA TG - #TGTTGTCA23580- AGCTGCTAGT ATGTGCTCTC TCCCGTTTCT TCTTGGAGGC ACTCAGAGAT AT - #GAGTTTTC23640- CTCTTAGAAA TGCTTTCATT GTGTCCCATA GATTTGGGTA CGTTGTGGCT TC - #ATTTTCAT23700- TAAACTCTAA AAAGTCTTTA ATTTCTTTCT TTATTCCTTC CTTGACCAAG GT - #ATCATTGA23760- GAAGAGTGTT ATTCAGTTTC CACGTGAATG TTGGCTTTCC ATTATTTATG TT - #GTTATTGA23820- AGATCAGCCT TAGGCCATGG TGGTCTGATA GGATACATGG GACAATTTCA AT - #ATTTTTGT23880- ATCTATTGAG GCCTGTTTTG TGACCAATTA TATGGTCAAT TTTGGAGAAG GT - #CCCGTGAG23940- GTGCTGAGAA GAAGGTATAT CCTTTTGTTT TAGGATAAAA TGTTCTGTAG AT - #ATCTGTCA24000- GGTCCATTTG TTTCATAACT TCTGTTAGTT TCACTGTGTC CCTGTTTAGT TT - #CTGTTTCC24060- ACGATCTGTC CTTTGAAGAA AGTGGTGTGT TGAAGTCTCC CACTATTATT GT - #GTGAGGTG24120- CAATGTATGC TTTGAGCTTT ACTAAAGTGT CTCTAATGAA TGTGGCTGCC CT - #TGCATTTG24180- GTGCGTAGAT ATTCAGAATT GAGTGTTCCT CTTGGAGGAT TTTACCTTTG AT - #GAGTATGA24240- AGTGTCCCTC CTTGTCTTTT TTGATAACTT TGGGTTGGAA GTCGATTTTA TC - #CGATACTA24300- AAATGGCTAC TCCAGCTTGT TTCTTCAGTC CATTTGCTTG GAAAATTGTT TT - #CCAGCCTT24360- TTACTCTGAG GTAGTGTCTG TCTTTTTCCC TGAGATGGGT TTCCTGTAAG CA - #GCAGAATG24420- TTGGGTCCTG TTTGTGTAGC CAGTCTGTTA GTCTATGTCT TTTTATTGGG GA - #ATTGAGTC24480- CATTGATATT AAGAGATATT AAGGAAAAGT AATTGTTGCT TCCTTTTATT TT - #TGTTGTTA24540- GAGTTGGCAT TCTGTTCTTG TGGCTTTCTT CTTTTTGGTT TGTTGAATGA TT - #ACTTTCTT24600- GGTTGTTCTA GGGCGTGATT TCCGTTCTTG TATTGCTTCT TTTCTGTTAT TA - #TCCTTTGA24660- AGGGCTGGAT TCGTGGAAAG ATATTGTGTG AATTTGTTTT TGTCGTGGAA TA - #CTTTGGTT24720- TCTCCATCTA TGGTAATTGA GAGTTTGGCC TGGTATAGTA GCCTGGGCTG GC - #ATTTGTGT24780- TCTCTTAGTT TCTGTATAAC ATCTGTCCAG GCTCTTCTGG CTTTCATAGT CT - #CTGGTGAA24840- AAGTCTGGTG TAATTCTGAT AGGCCTTCCT TTATATGTTA CTTGACCTTT CT - #CCCTTACT24900- GCTTTTAATA TTCTATCTTT ATTTAGTGCA TTTGTTGTTC TGATTATTAT GT - #GTCGGGAG24960- GAATTTCTTT TCTGGTCCAG TCTATTTGGA GTTCTGTAGG CTTCTTGTAT GA - #TCATGGGC25020- ATCTCTTTTT TTATGTTTGG GAAGTTTTCT TCTATTATTT TGTTGAAGAT AT - #TAGCTGGC25080- CCTTTAAGTT GAAAATCTTC ATTCTCATCA ATTCCTATTA TCCGTAGGTT TG - #GTCTTCTC25140- ATTGTGTCCT GGATTACCTG GATGTTTTGA GTTAGGATCC TTTTGCATTT TG - #TATTTTCT25200- TTGACTGTTG TGTCGATGTT CTCTATGGAA TCTTCTGCAC CTGAGATTCT CT - #CTTCCATT25260- TCTTGTATTC TGTTGCTGAT GCTCGCATCT ATGGTTCCAG ATCTCTTTCC TA - #GGATTTCT25320- ATCTCCAGCG TTGCCTCGCT TTGGGTTTTC TTTATTGTGT CTACTTCCCC TT - #TTAGTTCT25380- AGTATGGTTT TGTTCATTTC CATCACCTGT TTGGATGTGT TTTCCTGTTT TT - #CTTTAATG25440- ATTTCTACCT GTTTGGCTGT GTTTTCCTGC TTTTCTTTAA GGGCCTGTAA CT - #CTTTAGCA25500- GTGCTCTCCT GTAATTCTTT AAGTGACTTA TGAAAGTCCT TCTTGATGTC CT - #CTATCATC25560- ATCATGAGAA ATGTTTTTAA ATCTGGGTCT AGATTTTCGG TTGTGTTGGG GT - #GCCCAGGA25620- CTAGGTGGGG TGGGAGTGCT GCGTTCTGAT GATGGTGAGT GGTCTTGATT TC - #TGTTAGTA25680- GGATTCTTAC GTTTGCCTTT CGCCATCTGG TAATCTCTGA AGCTAGCTGT TT - #TAGTTGTC25740- ACTGTTAAGA GCTTGTTCTT CAGGTGACTC TGTTAGCCTC TATAAGCAGA CC - #TGGAGGGC25800- AGCACTCTCC TTAGTTTCAG TGAGCAGAGT ATTCTCTGCA GGCAAGCTCT CT - #TCTTGCAG25860- GGCAGGTACC CAGATATCTG GTGTTCGAAC CAGACTCCTG GCAGAAGTTG TG - #TTCCACTC25920- ACTAGAGGTC TTAGGATCTT GTGTGGAATC CTGTGTGGGC CCTTGCAGGT GT - #CAGGCGAC25980- TCTGCTGGCA AGGTAGCCCG GGGCTCGAGT CGAGTGGAAG GGACTTGTGC CC - #CAGATCAG26040- GCCCGGGTAG CCTGCTTCCC TATGTACTGC AGTCTCAGGT TCCGCGCGAT TG - #GATTGGGG26100- CAGGCACTGT GTTCCACTCA TCAGAGGTCT TAGGATCCTG TGGGGGGTCC CG - #TGTGGGCC26160- CTTGCGGGTG TTGGGCAAAC TCTGCTGGCA AGGTAGCCCT GGGCTCGAGT CG - #AGCGGAAG26220- GGACTTGTGC CCCAGATCAG GCCAGGGTAG CCTGCTTCCC TATGTACTGC AG - #TCTCAGGT26280- TCCGCGCGAT TGGATTGGGG CAGGCGCTGT GTTCCACTCA CCAGAGGTCT TA - #GGATCCCG26340- TGGGGGGTCC CGTGTGGGCC CTTTCGGGTG TTGGGCAAGA CTCTGCTGGC AA - #GGTAGCCC26400- GGGGCTCGAG CTCTTTTTTT TTCTTTAAAA AAAAATTTTT TTTATTAGGT AT - #TTTCCTCA26460- TTTACATTTC CAATGCTATC CCAAAAGTCC CCCATACCCT CCCCCTGACT CC - #CCTACCCA26520- CCCACTGCCA CTTCTTGGCC CTGGCGTTCC CCTGTACTGA GGCAGATAAA GT - #TTGCACGA26580- CCAATGGGCC TCTCTTTCCA CTGATGGCCT GCTAGGCCAT CTTCTGCTAC AT - #ATGCAGCT26640- AGAGACAAGA GCTCCAGGGG GTACTGGTTA GTTCATATTG TTGTTCCACT TA - #TAGGGTTG26700- CAGATCCCTT TAGCTCCTTG GATACTTTCT CTAGCTCCTC CATTGGTGCC CT - #GTGATCCA26760- TCCAATAGCT GACTGTGATC ATCCACTTCT GTGTTTGCTA GGCCCCGGCA TA - #GTCTCACA26820- AGAGACAGCT ATATCAGGGT CCTTTCAGCA AAATCTTGCT AGTGTATGCA AT - #GGTATCTG26880- TGTTTGGCGG CTGATTATGG GATGGATCCC CGGATATGGT AGTCTCTAGA TG - #GTCCATCC26940- TATTGTCTCA GCTCCAAACT TTGTCTCTGT AACTTCTTCC ATGGGTGTTT TG - #TTCCCAAT27000- TCTAAGAAGG GGCAAACTGT CCACACTTTG GTCTTCATTC TTCTTGAGTT TC - #ATGTGCAT27060- TGTATCTTGT ATCTTGGGTA TTCTAAGTTT CTGGGCTAAT ATCCACTTAT CA - #GTGAGTAC27120- ATATCATGTG AGTTCTTTTG TGATTGGGTT ACCTCACTCA GGATGATGCC CT - #CCAGGACA27180- ATCCATTTGC CTAGGAATTT CATAAATTCA TTCTTTTTAA TAGGTGAGTA GT - #ACTCTGTT27240- GTGTAAATGT ACCACATTTT CTGTATCCAT TCCTCTGTTG AGGGGCATCT GG - #GTTCTTTC27300- CATCTTCTGG CTATTATAAA TAAGGCTGCT ATGAACATGG TGGGGCATGT GT - #CTTTCTTA27360- CCAGTTGGAA CATCTTCTGG ATATATGCCC AGGAGAGGTA TGTCGGGATC CT - #CTGGTAGT27420- ACTATGTCCA TTTTTCTGAG GAACCGCCAG ACTGATTTCC AGAGTGGTTG TA - #CAGCTTTC27480- AATCTGACCA GCAATGGAGG AGTGTTCCTC TTTCTCCACA TCCTCACCAG CA - #TCTGCTGT27540- CACCTGAATT TTTGATCTTA GCCATTCTGA CTGGTGTGAG ATGGAATCTC AG - #GGTTGTTT27600- TGATTTGCAT TTCCCTGATG ATTAAGGATG CTGAACATTT TTTCAGGTGC TT - #CTCGGCCA27660- TTCGGTATTC CTCAGGTGAG AATTCTTTGT TTAGCTCTGA GCCCCATTTT TA - #ATGGGGTT27720- ATCTGATTTT CTGGAGTCCA CCTTCTTCAG TTCTTTATAT ATATTAGATA TT - #AGTTCACT27780- ATCTGATTTA GGATAGGTAA AGATCCTTTC CCAGTCTGTT GGTGGCCTTT TT - #GTCTTATT27840- GACGGTGTCC TTTGCTTTAC AGAAGCTTTG CAATTTTATG AGGTTCCATT GG - #TCAATTCT27900- AGATCTTACA GCACAAGCCA TTGCTCTTCT ATTCAGGAAT TTTTCCCCTG TG - #CCCATATC27960- TTCAAGGCTT TTCCCCACTT TCTCCTCTAT AAGTTTAAGT GTCTCTGGTT TT - #ATGTGGAG28020- TTCCTTGATC CTATTAGATT TAACCTTAGA ACAAGGAGAT AGGAATGGAT TA - #ATTCGTAT28080- TCTTCTATAT GTTAACCACC AGTTGTGCCA GCACCATTTG TTGAAAATGC TG - #TCATTTTT28140- CCACTGGATG GTTTTAGCTC CCTTGTCAAA GATCAAGTGA CCATAGGTGT GT - #GGGCTCAT28200- TTTTGGGTCT TCAATTCTAT TCTACTGGTC TACTTGTCTG TCACTATACC AG - #TACCATGC28260- AGTTTTTATC ACAATTTAGG TCAGGCATGG TGATTCCACC AGAGGTTCTT TT - #ATCCTTGA28320- GAAGAGTTTT TGCTAACCTA GGGTTTTTGT TATTCCAGAT GAATTTGCAG AT - #TGCTCTAA28380- TTCATTGAAG AATTGAGTTG AAATTTTGAT AGGGATTGCA TTGAATCTAT AG - #ATTGCTTT28440- TGGGAAGATA GCCATTTTTA CTATATTGAT CCTGCCAATC CATGAGCATG GG - #AGATCTTT28500- CCATCTTCTG AGATCTTCTT TAATTTCTTT CTTCAGAGAC TTGAAGTTTT TT - #TTCATACA28560- GATCTTTCAC TTAGTTAGAG TCACACCAAG GTATTTTATA TTATTTGTGA CT - #ATTGAGAA28620- GGGTGTTGTA TCCCTAATTT CTTTCTCAGC CTTTTTATTC TTTGTGTAGA GA - #AAGGCCAT28680- TGACTTGTTT GAGTTAATAT CCAGCCACTT CACCGAAGCT GTTTATCAGG TT - #TAGGAGTT28740- CTCTGGTGGA ATTTTTAGGG TCACTTATAT ATACTATCAT ATTATCATCT GC - #AAAAAGTG28800- ATATTTTGAC TTCTTCTTTC CAATTTGTAT CCCCTTGATC TCCTTTTCTT GT - #CGAATTGC28860- TCTGGCTAGG ACTTCAAGTA CAATGTTGAA TAGGTAGGGA GAAAGTGGGC AG - #CCTTGTCT28920- AGTCCCTAAT TTTAGTGGGA TTGCTTCCAG CTTCTCACCA TTTACTTTGA TG - #TTGGCTAC28980- TGGTTTGCTG TAGATTGCTT TTATCATGTT TACGTATGGG TCTTGAATTC CT - #GATCTTTC29040- CAAGACTTTT ATCATGAATG GGTGTTGGAT TTTGTCAAAT GCTTTCTCCT CT - #TCTAACAA29100- GATGATCATG TGGTTTTTGT CTTTGAGTTT GTTTATATAA TGGATTACGT TG - #CTGGATTT29160- CCATATATTA AACCATCCCT GCATCCCTGA AATAAAATCT ACTTGGTAAG GA - #TGGATGAT29220- TGTTTTAATG TGTTCTTGGG TTCGGGTAGC GAGAATTTTA TTGCTTATTT TT - #GCATCAAT29280- ATTCATAAGG GAAATTGGTC TGAAGTTCTC TATCTTTGTT GGATCTTTCT TT - #GTTTTAGG29340- TATCAGAGTA TTGTGTCTTC ATAGAATGAA TTGGGTAGAG TACCTTCTGC TT - #CTATTTTG29400- TGGAATAGTT TGTGCAGAAC TGGAATTAGA TATTCTTTGA AGGTCTGATA GA - #ACTCTGCA29460- TTAAACCCAT CTGTCCCTGG GCTTTTTTTG GTTGGCAGAC TATTAACGAC TG - #CTTCTATT29520- TCTTTAGGGG ATATAGGATT GTTTAGATCA TTAACCTGAT CTTGATTTAA TT - #TTGGTACC29580# 29604ACTT GTCC- (2) INFORMATION FOR SEQ ID NO:208:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 16442 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear#ID NO:208:xi) SEQUENCE DESCRIPTION: SEQ- TGTTCTTGTG GCTGTCTTTT TGGTTTGTTG AAGGATTACT TTCTTATTTT TT - #CTAGGGCG 60- TGGTTTCTAT CCTTGTATTG GGTTTTTTTT TTTTTTCTGT TATTATCCTT TG - #AAGGGCTG 120- GATTCGTGGA GAGATAATGT GTGAATTTGG TATTGTCATG GAATACTTTG TT - #TTCTCCAT 180- CTATGGCAAT TGAGAGTTTG GTTGGGTATA GTAGCCTGGG CTGGCGTTTG TG - #TTCTCTTA 240- GGGTCTTTAT AACATCTGTC TAGGATCTTC TGGCTTTCAT AGTCTCTGGT GC - #AAAGGTCT 300- GGTATAATTC TGATAGGCCT GCCTTTATAT GTTACTTGAC TTTTTTCCCT TA - #CTGCTTTT 360- AATATTCTAT CTTTATTTAG TGCACTTGTT GTTCTGATTA TTATGTGTGG GG - #AGGAATTT 420- CTTTTCTGGT CCTGTCTATT TGGAGTTCTG TAGGCTTCTT GTATGTTCAT GT - #GCATCTCT 480- TTAAGTTTGG GAAGGTTTCT TCTATTATTT TGTTGAAGAT ATTTGTTGGC CC - #TTTAAGTT 540- GAAAATCTTC ATTTTCATCT ACTCCTATTA TCCGTANGTT TGGACTTCTC AT - #TGTGTCCT 600- GAATTTCCTG GATGTTTTAA GTTAGGATCT TTTTGCATTT TGCATTTTCT TT - #GATTGTTG 660- TGCCTATGTT CTCTATGGAA TCTTCTGCAC CTGAGATTCT CTCTTCCATG TC - #TTGTATTC 720- TGCTGCTGAT GCTTGCATCT ATGGTTCCAG ATTTCTTTCC TAGGGTTTCT AT - #CTCTAGCG 780- TTGCCTCATT TTGGGTTTTC TTTATTGTGT CTACTTCGCT TTTTAGGTCT AC - #TATGGTTT 840- TGTTCATTTC CATCACCTAT TTGGATGTGT TTTCCTGTTT TTCTTTAAGG AC - #TTCTACCT 900- GTTTGGTTAT TTTTTCGTGT TTTTCTTTAA GGACTTGTAA CTCTTTAGCA GT - #GTTCTCCT 960- GTATTTCTTT GAGTTATTAA AGTCCTTCTT GATGTCCTCT ACTATCATCA TG - #AGATATGC1020- TTTTAAATCC GGGTCTAGCT TTTCGGGTGT GTTTGGGTGC CCAGGACTGG GT - #GAGGTGGG1080- AATGCTGCAT TCTGATGATG GTGAGTGGTC TTGGCTTCTG TTACTAAGAT TC - #TTACGTTT1140- GCCTCTCACC ATCCAGTAAT CTCTGGAGTC AGTTGTTATA GTTGTCTCTG GT - #TAGAGCTT1200- GTTCCTCTTG TGATTCTGTT AGTGTCTATC AGCAGACCTG GGAGACTAGC CT - #TCTCCTGA1260- GTTTCAGTAG TCAGAGCACT CTCTGCAGAT AAGCTCTCCT CTTGTAGGGA CG - #GTGCCCAG1320- ATATCTGGCA TTTGAACCTG CCTCCTGGCA GATTTTGTGT TCCACTCACC AG - #AGGTCCTA1380- AGATCTCGTG GAGAGTGTTC TGGGTACCTT GGGGGTGTCC GACAACTCCG TG - #TCCGACAA1440- TTCTAGTGCT GGGGCCGACT GGAAGGGACC TCTTTTTCTT TTATAAAGTA AT - #GAAAGCTA1500- TGTGTTGATT TTGGTGGCAA AAGAGAAGTT CAAAGTGCAA TAATGAAACC CT - #CCATTTCT1560- GAAACTCCAT CTCAGCGTCC AGTTGCCTGA ACTAACGCCC GTTCATCTTT CC - #TGCCAACC1620- TTAGTATTTT GTATATTGCA CACTTGAATG TTTATTGTAT CTAACGGATT TA - #TTCCAATA1680- GCACGTCTTT GGAAAAGATG ACTACAGGGC AACTCTCAAT ATAGAATGTT GA - #GTGTCTGT1740- TTGACCTTTA ACATCATCAC CTATGTTTCC ATCATTTTAT TGATGAGATG AT - #TACATCCT1800- TATATTCAGC CACGTATTCA TTTGGTTTTG AGATCAAAAC CATTCTTGCC TA - #TTCCGCTG1860- CCTTCTAGGA ACAGCATCTT TAACGTTTCA GCCCTTTGAT ACCCACATTA TG - #GAACCTCG1920- GAGTTAAATT CCTACTGTCC ACTATGAATG AGGTCTCAGA TGGGAGGCTT GT - #TTTTTTTG1980- TGGTCCCTGG GGACAGCTGA CTATGACTGT GAATGTTTGC TCTGTCCCCC TT - #TCACTCCT2040- TCCAGTTGAA GTGCGCAGAG ACCTGGAGCC TCAATGGTCT GGTTAAACAC GT - #CTTAGGGA2100- AACAACTTTT GAAAGACAAG TCCATCCGCT GCAGCAATTG GAGTAATTTC CC - #CCTCACTG2160- AGGACCAGAA ACTGTATGCA GCCACTGATG CTTATGTATG TATTTAAAGA CC - #TTTAATAT2220- GACATCATTC TCATTTCTCG GACCAAATCA CTTTAGTAAA AATGTATTGG GG - #TTATGTCC2280- TTAGCTGAAA TATTTTATTA TAGTTTGGCA TTAAAATTTG CTTAGGAATA CA - #TCAAGTGA2340- AATTCTTCAT GTTAATTAGA AAATACCAAT TAATAGGTTG TTTAGCAGTA GT - #TATTTCTA2400- CTATTACGAT GTAAAGTGAT GTCCAATTCC TGTGTAAAAG AATGTGAACT TA - #CTGAAAAC2460- ATGAAAGGCT TTGAGCTTAG CAGGCACAAA TAGTTTGATG ATGTATTTTG TA - #TATAAGCA2520- ACTCAGAATC AGAAAAATCA CAGGCTTTCC ATATTTAAAC TAGCCTTATT CC - #CTACATTT2580- ATATTTAAAA TGTGGAAATT TAGATAAATT GCCTCCAAAT TTAGTTGCTG CT - #GTTCTTAG2640- ATGTATTTTC ATATGTGTAA TCTGTACATA CTGGCATCTA GGCTTGTCTT TA - #TATATAGT2700- ACTGTGGTCT GTGTGTGCTT TACCTTAAGA AATGTTTCTT TTGTAAATTT CT - #TTGCCCTA2760- GATCATACTT ATTGCTCATA TTTAAATAGT ATTTATTGAT AAATATCTTG TT - #AATTTTCC2820- ACCTTACATT TATTTTTAAG ACATCGATAC TCTAACTTTT AGCCAGAAAA AC - #AAAGGAAA2880- ACCAACTGTC TTAGTCAGGG TTTCTATTCC TGCACAAACA TCATGACCAA GA - #AGCAAGTT2940- GGGGAGGAAA GGGTTTATTC AGCTTACACT TCCATACTGC TGTTCATCAC CA - #AGGAAGTC3000- AGGGCTGGAA CTCAAGCAGG TCAGAAAGCA GGAGCTGATG CAGAAGCCAT GG - #AGGGATGT3060- TCTTTACTGG CTTGCTTCCC CTGGCTTGCT CAGCCTTCTC TCTTATAGAA CC - #CAAGACTA3120- CCAGCCCAGA GATGGTCCCA CCCACAAGGT GTCTTTCCCC CTTGATCACT AA - #TTGAGAAA3180- ATACCCCACA GCTGGATCGC ATGTAGGCAC TTCCTCAACT GAAGCTCCTT TC - #TCTGTGAT3240- AACTCCAGCC TGTGTCAAGT TGACACAAAA CTAGCCAGTA CAGCAACAGA TG - #CTTTTTGT3300- CAGGAGAACA GCTGGATGAG TTGGGATGTG CTGTTGTTCC TTTGGCTTCC TT - #TGCTTCCT3360- TGCTTACTTG CTTTAAAAAA AATAACAGAC TCTCTTGCAG CTTATTCCAC TC - #TTGAACTG3420- TTCATGCAGC CGAGGCTGCC CTTAATGTCC AGATCCTCTT GCCCCTGTTT CC - #TTGCTATG3480- GAGATTACAG GCTGTAGTGT CTATATTCTT GACAGTTTGT ATGACTTGAT CA - #AGTCTGTG3540- AAAAATACCC AGCATGCATT GTTGTTCATA CACTGACCAG CATTCTCAGT TG - #GTTTAATG3600- AAATCTCAAG AATTGGATAG GATCTGTCAC CAAAACAGAT GTTTCTTACT AG - #ATGGTAGT3660- TATTAGATTT TGTTTACAGA TCATTTCATT TGGATACCTA TTTACAATAC TG - #AAAATTAG3720- TAAGTGAAAA TTTAAAGCTG TATTTTATAG CCTAGGCAGC TTTTGTTTCC CC - #ATTGGGTA3780- GTGCTTACAT GAAGACCCGA GTCTTTGCAT ACTGAAATAG TTTTACTTCA TT - #TTTGGAGA3840- GTATTTTGGA AATCATTCTT GTAGATGTTG CTTGAGATAT CACATATATA TA - #TTTATTTT3900- GGTAATCTTT AACTTGCACT TTGTTTTTCT TTTGTCTTTT TATAGGCTGG TC - #TTATCATC3960- TATCAAAAAT TAGGAAATTT GGGTGATACT GTGCAAGTGT TTGCTCTAAA TA - #AAGGTATG4020- TTGTGGCCTA AAATAAAAGA TAAAAATATG AATTTGCTAT TTTGTGAGAT TC - #ATTTAAAA4080- AAGTCAAAGT ATTATGTATC TTTGCAAAGT ATTATGGTAC TTCTTAAATG TC - #TGAGCAGT4140- GTTGCTGTAA AGGTGACATC CATCAGGATC AGAAATTAGA GTTGTAGATC TT - #CCCTTGTG4200- AAAAGCAGGG ATTCCATTGC TAGTTTGATA GTGTTGCTGC TCTTCTTGTC CA - #TGGAGTGG4260- CCATGTTATT GTCCTTGATA ACATCAGTTA GCCAGCCAGC TGCCTCTTGG CT - #GGTAACAT4320- CCACATTCTT TCTACACTTG TTTAAAACGG ATTTGCCTCG ACTATTCCTG TG - #TATATGGT4380- GCACTGTAGT GTTCTGCCTT TCTGTGTTCG GTTGCTGTTT TCTTCACTCA GC - #TTCATTGA4440- CCTTGTCAGA TGCTTTGATC TGTTAGTGAT TACAGGCAGA GTCAGCCAGT AG - #GTGGATAA4500- GCACCAGCTT TTGTGCTGCA GAACCTCTGT GGTGGAGCCT TAGCCATCTG AC - #CTGTAAGA4560- TGTCCCTTTC CCCATGCTTG TAATGTGGAC AATAGATAAG TGTCTATCTC AT - #GGATTGGT4620- TGTGACCACT AAAGGGACAG ATGTTCAAAG TAAGATGGTC AGAGAAAATT GT - #TAAATAGA4680- TTGAACAGTC CTATAATACA TGATCTGAAA TGCTTTGAAA TCGGAAACTT TT - #TGGTGATA4740- ACATGATTTA CGTATTCATT AGTATATTTC ATTGAAAATA TTTCCTGGAA GA - #AGCAATAC4800- TTGAGAAGCC TGAAATAGGA ACAGAAATTT GCCAGCCAAA GCCAGAGGGA AA - #GTGATAGA4860- CAGGTACAAA GCCTCAGAGG GCAGCTCTCT GGAACTTATG CAGTGTAAGG AA - #ACTGTTGA4920- CTGTGACAGT GTAATGTAGG AGAAGCAGAA AAATGAGACA GGCCTCACTA AA - #GAGGTTAC4980- ATGTAGCCTT CCAAAGAGCA AATTGAAGCT GTTATTGACG GTTCTAAATG TG - #GAAGTGAA5040- ATGCGCTGGA TTGAAAACAA GCTAACAAAA CAAGCTGTAG AATAAAACAC AC - #TAACTAAG5100- CGAGCCACAG AGAAAGAAAG TGGATCTTAG GATTACAAAA GAATGGTGGG AA - #AGGCTTTT5160- TGGAGGCTAT GATGGTAAGC CAAGAAAGAG GAATTGGTAC CTTGAATTGG TT - #ATTTGTGT5220- CAAGGGTCGG CACAGTGGGT AGCGTCANCC TACATTTAAT GGAGGCAACA GA - #ATCTGCTG5280- TAATGACAGG CACACGCCAA GGATCCTCCT GGCTTTTGGC TGCACGACAG AT - #TAAAATCC5340- AGGGTAAAGA CTCACTTTAT ATAGACCAGG CTGGCCTAGA ACTCAGAGAC CT - #ACCTGCCT5400- CTGCCTCCTG AGTGCTGGGA TTAAAGGTGT GCACCACCAC CACTCAGCTG GA - #AGTAAAGT5460- TTTATAGTTG TTTTTTTAGA CATGTTCAAG GAGAGTAACA TCTCAGGTAG CA - #AGAGGGTT5520- GTAGCCTGTG GACACCTAGA TATGTAGGTT GTATCTCAGA AGACAGTTTG TC - #TGAGATAA5580- AATGTAAGCA CTAAGTGTCC TAAGAAACTG CTGGCGTCTA ATCTTTGTGT GG - #GGGAGGGG5640- ACCCTATAGG AGTTGCCCTG GGTGTGGAAG GAGATGAGAA AGTGCTGGAC AA - #TTCAAGTA5700- CCAGTGTGCT GAAAGTCAAG GGAGGGCTAG GTTTGAGGGA GGAGGATGTT AT - #CAACTGCT5760- TTGAATTCTG CTGAGATTTT GGCAAAGTGA AGGCTTGTAG GCAATCATCA GA - #TTTGGCAC5820- AATGGCCACT ATCATTTGTA ACCTTCTACA CCAGTGGTTC TCAACCTTCC TG - #TACTGTGA5880- CCCTTTAATA CAGTTCCTCG TGCTGTGATG GCACCAACCA TGACATTATT TC - #CTTTGCTA5940- CTTCTTGACT GTAATTTTGC CACCGTTATG AATTGTGATG TAACTATCTG AT - #ATACAGGA6000- TGTTTGATTT GTAAACCCTG TGAAAGAGCC ATTTGATCAA TCATTGTTCT GT - #GCTCTACT6060- TCTGGTGTCC TGGGTGTTGA CAAAAGAGTA TTGCAATCAG AGGGTGAACT TC - #TAGAGCAG6120- ACAGGGTCCA GAGGCTTTGG TAGTATAAAA ATATTATAGG CATAGCAAGA AT - #AAAGTAGT6180- TTAATGAGGT AGGTAGAAAC CAGTACTAAA ATTATATCAA TCATATTACT GC - #AAATAGTG6240- GAGAAAGATG TAAGGAATTG ATTTTAAGTG TATATAAATA ATATTTTTTA AA - #GACTTAAT6300- TTAGAAAGGG AACGTTCATA AAACACAGGT TTGTCTAGTG TTTGCTATAT TT - #TAGTGTTC6360- ATTATGTATT GATTTTATTT GACAAGCAAG GTAACATGCT ATTTGGCTCT CT - #GAAGGAAG6420- AGAGCCAAAT GCTTAGAGCT GAGAAAGTAC AAAGCCACTG AGGGCAACTG CT - #TCCCTAGT6480- GTAAGGAACA GAAATATAAC CAAAGAGAAA CGAGTGTGAG GGAGACTTGT AG - #GAAACAAG6540- GCTGGAAAAG AGGCTTGGGG CCAGTCAGTT AGGGCATCAG ATTGTGTGAA TT - #GGACTTGA6600- TGTTTTAATA CTCAAAACCA TCAACAACCA CGGTACAACG ATGGCCAATA GG - #AAACCCTT6660- AGTTTGGGTG TGTGGAGCAG CAGAGTAAAA TGATCCAGAT TTTGTCTTAA AG - #TGTTTTTT6720- TTTTCTCACT GCTGTAAGAA GGTCAGGAAG TTAGATAGGA GGCTTTTTCA AT - #TGTCCAGA6780- AATAGAAGAT AGTTGTACTG GGCCAGTGGA GGTAGCAAGA AATGTAAATG CA - #GTAGGTAT6840- TCTGAAGGCA TACACTGAAG AATTCTAGGT GAATTCCTTA TAAAGGGTGA GG - #AAAAGACT6900- GCTAGGATGG CCAAGGTATT TTTCTTTTCT TTTCTTTTTC AGTTTTTCGA GA - #CAGGGTTT6960- CTCTGTGTAG CCCTGGCTGT CCTGGAGCTC ACTCTGTAGA CCAGGCTGGC CT - #TGAACTCA7020- GAAATCTGCC TATCTGCGCC TCTCAAGTGT TGGGATTAAA GGCGCCCGGC TT - #AAGGTATT7080- TTTCTTGAAT GACCTGATGA CTGGCAGTGC AGGATGATAT GAAGAGTATG TT - #TTGGTTGG7140- AAAAAATCCA CCAAAGTTGC AACGTGGACA TGAAAAAAAA CTAGAGGTGG AT - #TTTGATAT7200- CCACGAACGG CTCCATACTA GTTATTTTCT GTTACTGTGA TAAAACACCG TG - #ACCAGAGA7260- GGTCTTTAAG GAAAGGAGTT TCTTTTTGCT CACAGTCCCA GAGGGAAGTC TT - #CAGTGGCT7320- CTGCGGGAGC ATGGCAGAAA GCAGCCGGCT TGGCAGTGGG GCAGGAAACT GT - #TAGGTCAC7380- ATCTTGAACA GCAGTCTTGA AGCAGAGAGA GCAAACAGGA AGTAGGGTGA AG - #CTGTGCAC7440- TCTCAAAGCC ACCCCCAGTG TCAAACTTAC TCCCGGAAGG TTGCACCACC TA - #AACCTCTC7500- CAAATGGAGT CACCAACTGA GCATCCAGTG TTCCACTGCC CGCGAGCCTG TG - #GGAAATAT7560- TTCCCACCTA ACCACCACTG CACTGTGAGA AATGGAATTC CAGAGTACAC GG - #CGGAAGTT7620- GGGGTTAGAA ATATAGATTG TCCAGTGGTG AAACTGGAGA TAAAACTGGG AG - #TGAATAAA7680- CTGAAGAATA TAGGTGGTGT CAGCTTCAAG GTCACACTGA CATTTAGAAA AT - #GAGAGTGG7740- CTTGAGGGCG GAGACGGGGC ATCAGTGAAT GAGGAGGGGG GCGAAGGACA TG - #CTTTAAAT7800- AGGAAGGAGA CATCAGCCCC TTAAACCTCG GAGGAGTTGA ACGATGCACA GA - #TCGTGGAT7860- TAACTATTAG GGTTGATAAT GTGGTAGCCT TCCCAGAGGA AGCTGTGCTG CT - #GAGGGCAA7920- AACTCTTGAG TTGGAGTTAG TTTAGGAGAA AATAAGAGCA GAACATTCGA GG - #ATGAGCAG7980- CAGGCGTTGG AAACGTAAAA GAGAAAGAAG AGGTGTAAAA TTGTCATCTT AA - #GATAAGCG8040- GGGTCTGCGT CATGAGTTTA AAACTAAACC GGCCATTATC ATTTTGTTTT AA - #TTTCAAGA8100- ATGTCCAGCT ACTTAGGCAC CGATTAGCTA AAGAAGTTGA GTATGATTAG AG - #TAGATTTT8160- GCCCCGTGAG TTCCACGGAG TTGGGTAAAG AAGGCAGAAG TGGAGAGTCT GT - #ATCAAATG8220- AATGGCTAAG AAAGGAAAGG AGACCAGGTA GGGAGAGTAG GAGTGGGTGC TG - #GAGGGGGC8280- GGATTCAACA GGTTTCATTC TGAAGTGTTA ACTCACTGAG CTGGGGTAAG CA - #AGCCAGAA8340- AGAGCGGTGG GATGGCTCTA TTTATGGTGG AAAGTGTTTG TAATAGAAGG TT - #TGGGTGCA8400- GTGGAGGTTT TATTGGGCAG TTTTAAGGTC GAGAGTCTGA TTGTGGGAAT GA - #GTAGCTCA8460- GATTAGATGA GGAAGATTGT TGGAATGAAG GGTGACCCTT GGGCAAGGGT TC - #CAAACGGT8520- GTTAAGTTTG AACGTGCCTG GATTGGGGCT TACTGACTTC CAAGTCAGAA AC - #AGTGTCGG8580- GTGAGTTTAG AGTCCCAGGC TTGTCCTCTG GCCCAGGTCA GTAACATTTA GA - #TTGGATAA8640- TGTATACATT TGGAATTCAC TCTAAATTTC AAATAGCAAA AATTTGAAAG GA - #ACATTAAA8700- ACAAGGGAGT AAAGAGGAAA GTGATTTAGA GATCCGAGAG GGAAGTGTTC TG - #TTAGAATT8760- CATTGTGCGA ATAGATGAAA ATCTGGATAC TAATACTATG CTGTGATGTG GT - #TAAATAAA8820- ATCTCTGCTT TCTAATTTTA ATATTAATCT TTTCTCTCTC TCTCTCTCTC TC - #TCTCTTTC8880- TCTCTCTCTC TCTCTCTTCT TTTATTTAGC AGAGGAAAAC CTACCTCTGG AG - #ATGAAGAA8940- ACAGTTGAAT TTAATCTCCG AAGAAATGAG GGATCTAGCC AATCGTTTTC CT - #GTCACTTG9000- CAGAAATTTG GAAACTCTCC AGAGGTTAAA TATTGTGCTT TTTAAAATAT TT - #ATTTTATT9060- TTTAATTGTA TGTGTATGCG CGTTCAGTCA CCTTTTATGC TATTTTCTTA AA - #CATGGAAT9120- TCTGATTTTT ACAGAATGCC TGCTTGTTAT AAATTACATA TACCTACAGC TT - #GGCTTTAT9180- AACAGCAAGT TAAGTAGGAT TTATTAGCAT CAAGAACTCA CAACAGAGTG GT - #TTGAAGTT9240- TATTGTAGGA AGGAACAGTT GTTTTTGTCT CAGAGGACCC TAATAGAATC GA - #TGTGATTT9300- AGTATTGTTT AGTCATTTAT TTACATTCAG TGTGCTGCGG TGTTGCTGCA GT - #GTGATTAG9360- CACTCTACTG GCTGTTGAGC TTGTCTGCTG CTAACTAATG AGCAGGATAG AA - #ATCTTAAG9420- GAAGGAAATG TGCATGCCAC CATGTATGCC TTCCTAGTCC AGCCTTTAAC GT - #TAGAGTAA9480- GTGGTTATGT CTTACTCTGA TGTGAGTGCT TGGTAAATAA GATATTATAA TA - #GTATCACT9540- GTTGCTATAG CAACACATTT ATTTCACAAT TAAATTGAAT CATAACTTCT CA - #TACCATAT9600- TATTTATACA CAGTTGTTAT ATATAAGCAG TATATGTATA TACATATAAT TA - #TATACTGT9660- GTATGTAGTA AAATTTACAA AATTGCCAGG CACCACGGTA CATACCTGTA AT - #CTGTGCAT9720- TCAGGAGGCA GAGGCAGGAG AATTCCAAGC TCAAGGCCAG CCTGACTAAT AA - #AAAGCTTT9780- ATAAATTTTT ATTATTTTAA AATAACTTGT TATTAGATTT TGAATTTAGT TA - #ATAGTTTT9840- AAAAGTTTTT TTTTTGTATC ATTTTATGTG TATGGCTGTC TTTGCCTGCA TG - #TATGTCTC9900- TGTACAACTT ATGTGATGTA TTCCTGAGAG GTGCAGAGGA GGGTATTGGA TC - #TTCTGGAA9960- CTGGTGTTAC ACACAGTTGA AAGCTGCCAT GTGGGTGCTG GGAATCAAAC CT - #GGGTCCTC10020- TAGAAGAGCA GCCAATGCTC TTAACTGCTG AGCTATCTTT CCAGCCCTGA AT - #TTAATTTT10080- GATCTTGATT TTTGCTTATG TTAATATAGA CTTTGACAGT TTAAGGTTGA GC - #TAAAGTTG10140- GGAGAGTTGA TAATTGTGTA GTTTTGTTTT TTTGAGTATT TTTGTACATT TT - #ATTATGAT10200- CATAATTACT TTCCATTACA CTCTCTTATC CCCCTGATTC CTGCTGACTC CC - #TCTTACTT10260- AAGTAGCTCC TTTCCTTCTT TCACGTCTCA TGTGTGTTTG TGTATTTGTG TG - #TGCATGTG10320- TGTGCATGTG TGTGTGTGTG TGTGTGAGTG TGTGTGAGTG GCACTGTGTT TA - #TTTAGGAG10380- TATTTGTATG AGCATGGTTA AGAGGCTGCT GACTAAGCAC TGGCAACTTT AC - #CAGTGACT10440- ACTGAAGAGA ATGATGACTG TTTGCCTAGA AGCCAAGCAA AAGCTCCCTA GG - #GAAGGATG10500- GGGTGGGTCA CTTTTGAGCT TCACCATCCA CGTGGGAGCG GCAGAAGGCC CT - #GTGTTTTG10560- TGGGTTTTAT GCAGATATCC ATAGCTGCTG CGTGTTTATG ATTTCAGTAG CC - #ATGCAATG10620- TCTACATGGC AATGTTTCAC AGCACTCCCC CACATCGTCT GACTCTTACG GT - #TTGTCCAT10680- CCATCCTGTT ATGTCCACTG GGCCATTGAA GGAGTTTTAT GTACAGGCTG GT - #CCCAATTC10740- AGGCAGAGCA CCCAGTATTC ATTTATGCTC AACACTTTGA TCATTGTGAG TC - #TTCTTTAG10800- CCAAAAGCTT CTTTGACCAA GACTGAGAGT AGCACTCTGG ATAAGAACAA GA - #GTTCGAAG10860- GCAATATGAT ATGTGTCTAT CTAGCAATGT GTCAGCAGTT GGTACCCCTC TG - #CTATGGCC10920- TGTGATCTCC CCAGCCAAAG GCTTCTGACC AGATTTATAC TTCCAGTCAC GT - #ATTCCCTC10980- CTGAAGGTCC AGGCTTCAAA TGCCTCGATT GCTGATTGAT GTGACCCACC CC - #CAGTCATG11040- TCATTGGTTC TCCAGCAGAC ATACCTTGCC TGGCAGGTTG GTACTGTAGC AT - #GCAGGGTA11100- CAGAGTTGGG TAAGACCCTT GATGACCATC GCCACCCCTC CCCCCTGGCA GG - #TGGCATAG11160- TACCTTTTCC AAGTATGAAT GCTGACTGGC AGGATGAAAC TGAAGCATCC GG - #TCAGTTCC11220- AGTTTGATTT TTCTGTGTCT TGTAAGAATG AGCTCCCAGT GTAGGACCAA CC - #CCTGGACA11280- AACTCAGACT TTGATGGTTT ATTCTCATAG AAGAGCAGAG TTTCATCTGA AC - #CATTAAAA11340- TAAAAATTAG CTGGAACTAC CTGAACATTT CTGGTTTTAT AAATCATTGA GT - #TAAATATT11400- GGAAAATTAG AATACATAGT CCAAAGCACT TATTACATAA CAACATACGT CT - #CTTTGTTT11460- ATTACCATCT TTTGTCTTTC TCTAATTTCC TCACTTATTT AGGTAATTTT TC - #TTTCTTTA11520- GTGCTGAGGA TTGAGCTTGA AGCCTTGTGC ACTCCAGGCA AGCATCACAG AG - #TTGTCTTT11580- AAAGTAGTCC TGTTGTTTGG TGTTCTGCAC AGTGTTTCTT ATTTACACTA CG - #TTCAGAAT11640- GTATTACCTA CAATTTCTAC TTTTAGTTTC TTTAAAGTGG AATGATAATT CA - #ATATACTT11700- GAAGTCATGT GACTACAAAG TCCTAAGAAT TTTTAAGTTT TTTTCTTATG AG - #CTTTTGCA11760- GTTATTTTGA CTATGGGGCA TAATTTTTTG ATTATAATTT TTATGTAATA GA - #TAATTATA11820- TTTTTCCTAT CCCCCAACCC TTTCCAGATC CTAACCACCT CCCTATCCAC CC - #AAGGTTTG11880- AGCCCCTTTC TATCAACAAT GAACAATCTA ACAAAGAAAA ATCAGAACAA AA - #AACCAGTA11940- AGGAAAAACA GATACCTCAA CAAAATGAAA TTAAAAGCCT ACAAAAAAAA AA - #AAAAAAAA12000- AAAAACCAAA ACAAAACAAG GCGTTCATTT TGTGTTGGTT ATCTTCTCCT GG - #GCATGGGG12060- CCTGCCCTGG ACTGTTGCCA ATACATCCAG TGACACGTAA TTAGAGAAAG CA - #GATTTTTT12120- TTCTTTCCCA GCTTTTGCAA AGAAGTTTTT AGTTAGGAGT GCTGGGATTT TG - #TCTAGATT12180- GAACCTTTGC TATTCATGTG CAAGCTACCA CAGTCTCTGG GAGTTCATAT GT - #GCATCAGT12240- CTTGTGTCTG GAAGACAGTG TTTCTGTGTC ATTTTATTGT AAAATTTACT AC - #TTAACTGA12300- GAGTTATCAA TAATTTTTTT TTCTTTTTTA GTTTTGTTTT TTGACTTTGT TA - #TTTTGTGG12360- TTAAAGTGTG GCTTGCTTCC TCCTCTTCTG ATTTACTGGT CTGGGATTGT TC - #CTTCTGTT12420- TTCTTGGATG TGATTAACTG CTTCAGACTA AAGTTTTCCT TCTAATGCCT TC - #AGTAGTGT12480- TGGTTTAGTA GACTGATATG CTTAAAATTG GTTTAATCAC AGAATGTCCC CC - #TCGCCCCC12540- AAGCTACTGT GATTGATAGT TTTGCTGGGT ATAGTAGTCT GGGCAGGGAT TT - #GTGATCTT12600- TCAGAGCTTG TAGACTATTT GCCCAGGTCC TTTATGGGTT TTTAAAATCT CC - #ATTTAAAA12660- GCCAGAAGAT ATTTTAATAG CTCTGCCTTT ATATGTTATA TGGTCTTTAA AC - #CTTGTAGC12720- CTTTAATATT CTTTCTTTCC TCTGTATGTT TAGTATTTTG ATTATGTGGC GA - #GGGATTTC12780- TATTCCTATC TATTTTGTTT TCTGTATACT TCTTGTACCT TAAAACGCAT TT - #CCTGCTTT12840- AGATTGGGAG AAATTTCTTG TATGGTTTTG TTAATAATAT TTTCTGTGAC TT - #TACATGGA12900- TTTCTTCTCC TTCCTTTATA TCTACTTTTT ATAAGTTTGA TCCTTTCATT GT - #ATTACAGG12960- ATTTCCAAAT GGCTTGTGCC TGCGTCTTTT TAGATTTAAC ATTTTTTGAC TG - #AACTGTAC13020- ATTTTTTTCT ACCTTGTTTT TAAGACTTGA ACTTCATTCT TCCATGTTGT GT - #GATATGTT13080- GATGACACTT ACCTCTCAAG TTTTTCTTTA ACACCCTGAG TTTTTCATTT TA - #GAAAATTT13140- ATTAACAAAT AACAAATTTA CGAACAGAAC TTTATTGGCT TTTCCCATGT GT - #TTAGTCCA13200- GAATAGAATG AAATAGTTTT TGCTTTGTTT TTTGTCATAT CTTATTGCTG CA - #GTTTACAT13260- TTCATTAAAT TAATTATCAA AAAGGGCCAT CTGGCATAAA GGGGATGGGG AC - #TCAGAGTT13320- AGTAAACTCT GAGTGAGTAT GCAAGGCTAC TTCTACAATG AGAAGCACCT GA - #TCACACAG13380- GCAAGTTGGC TGTTACTCAT ATTCACGTGT GGCCACATGG AAATAAGGAA CA - #GTTTTAGT13440- CCCAATGGGT CTCCTCAGTA AGCCTTCGTT CAGTAAGAAC TTTTAAAGCT CA - #TCTTTACA13500- ATGAATAAAA TTAGAGCTGA ATAATGCTTA TTGAATTTTT TTTAGGGTTC CT - #GTAATATT13560- GAAGAGTATT TCAGAAAATC TCTGTTCATT GAGAAAAGTG ATCTGTGGTC CT - #ACAAACAC13620- TGAGACTAGA CTGAAGCCGG GCAGTAGTTT TAATTTACTG TCATCAGAGG AT - #TCAGCTGC13680- TGCTGGAGAA AAAGAGAAAC AGATTGGAAA ACATAGTACT TTTGCTAAAA TT - #AAAGAAGA13740- ACCATGGGAC CCAGAACTTG ACAGTTTAGT GAAGCAAGAG GAGGTTGATG TA - #TTTAGAAA13800- TCAAGTGAAG CAAGAAAAAG GTGAATCTGA AAATGAAATA GAAGATAATC TG - #TTGAGAGA13860- AGATATGGAA AGAACTTGTG TGATTCCTAG TATTTCAGAA AATGAACTCC AA - #GATTTGGA13920- ACAGCAAGCT AAAGAAGAAA AATATAATGA TGTTTCTCAC CAACTTTCTG AG - #GTACTGAA13980- TCAAGAGGGA ATAATATATT CATCAGTGGT TGGTTTACTT TGTTGTATAA AT - #GCACAAAG14040- AACAAATATT TTAGTTTTTG TGGGATGCAT GGTCTCTGTT GTACCTATCC AG - #TTCATCCG14100- TTGTAAAGCT GCCATAGACA CATGCAAGCA GTGGTACCTG TGTGCTTCAG TA - #AAACTTTA14160- TTTAAAAATA CAAACAGAGG GCCATGTTAA CTTGTGAGAT CCACTTAATA CA - #ATAAGTAG14220- AATTGTATAA GTGAAAAATT TTGCTGCTTT ACTATTTATG TTTTTTATAT GA - #TAGGTAAT14280- AGTTTTTTGG TGGATTCTTC CTAAGTATTT ACTCATTCAA ACTTGATTTG GG - #GGGTGGGT14340- GGGTTTTATT CCTTCAAATA GAAATTATTT GTTAGGGTGA AAGGGTCCTT TG - #ATTTACAG14400- GCATCCATAC TGTGACCTGG AGAGCCAGGA AGCTCTTGTC TCCTTCCTAA TT - #CTTATTAG14460- CTTGCAAATT ACTGAAGACA TTTATCATTT CTGGGAGGTT TTTCTTTTTC TT - #TTCTTTTC14520- TTTTCTTTTC TTTTTTTTTC TTTTCTCTTC TCTCTTTTTT TTTGCAATAA CA - #AATTTCAT14580- TTTAGATTTT GAAAAGATTG TATAGGTTTA AACCTCTCAA TTTCATTACA GA - #AGTGGAAA14640- CCCAGTCTTA TATACAATTC TTTGATTTTT TTTTTACAGG AGTTTTTCAA TT - #GTTTCTAT14700- TGAGTATATA AATGTAAATT GTTTTAAAAA TTTCAAAATA TTCTCATTCT AA - #TTTTTTGT14760- GAACCAGATT CCCTCTCTAG AAAATGCTGT CTTTCACTTA CATGTGCATC AT - #TCTAATTC14820- TGTAGAAATT TCTAATTAGA TCTGCACTTT CATATTTTTA TATATTAGAG AA - #TTATGCTC14880- ATGAGTTTGA TTTGACTGAT ATCTTTTATA TCAATTATTG CCATTTTATT AT - #GTAATGAT14940- TAGCATCATT TTTATTATTT AAGACTGCGT TTAGAAGTCA AGAAAACCTT AC - #TCAGTTAA15000- AAGTGTACTT TAATACATTT TAATAGCTTT AAATTAGCAT GTTAATTAAG GC - #TATTTTCA15060- TTTTCCCATT AACAAATTAA ATATGAAGCA TTTGGGGAGA TATTCCTTCA AG - #TTTCTTCT15120- TGATTTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGAAGGG TA - #GATTTGCA15180- GCTTGTTAGG CACCCGGTTC CTTGGGATTG CCAAATTATT GTAAAGATTC TT - #CATATCCA15240- AACATCAACA ACAGATCAAG AAAATAATAT ATTTAGTATT TTTTCAAATA GA - #TGGTCTTT15300- GTAAAACACT AATTTATTGA AAGATTATTA TGTATTAGTC TTTGGTATTT TT - #AAGTCAGT15360- GTATGTAAGA AAACCATTGA TTTTCTTGGT TTGTACAGAC TTTTTTCAAC AT - #TGATTAGA15420- ATGCCATCTA TTGGAAAGTT GGGGAGACCC AGGTTGACCT GGTTGACCTT CA - #ACTTGCAC15480- TTTCTCTTCT TTTGCATGTA GATTCTACTT GACGTCTGTT TATCTAACTT GC - #CTGTCTTT15540- TTAATTACGC TCTCTCTCTC TCTCTCATTA TTTGAAGATT AAAACACTCA TT - #CTCCTTTC15600- TCTCCCGTCC TCTCTGTGCT CATGCTGTGA ACATATAAAT ATGCTTTAAA CA - #TCTGCCTA15660- TTAAAGAAGA GGAAGATGTC TAAATACTTC AGTGAAAGCA GCTGAGAGCA TA - #GTGTCACT15720- CTCGCAGAAC GTTAATCTTT GAAATCCTTT TCTTTAAAGC ATTTATCTCC CA - #ATGATGAT15780- GAGAATGACT CCTCCTATAT AATTGAAAGT GATGAAGATT TGGAAATGGA GA - #TGCTGAAG15840- GTATGTTTGA ACACAAGAGA AAGTTACTTC AAGTTTTTAA AAGAACACTT TA - #ATAATTAA15900- AATATTATCC ACTTCCAAAT CAGATGCCAC CACAATGATA TTCATACCCA TT - #ATTTAATG15960- TTAGACTTTA AGTTTTCAAT TTACATGTCC TCATCTGTAA GTAGTCTTAG GT - #GTAACGTT16020- GGGAGTTCTC ACGGGAGTTC TGTGTCCTCA TACGTCTCTC TCTCTGGAAA CT - #GGGCAGTA16080- ACTAAGCACT TGAGCAGGAA ACTCATTATT TCTTCTTCTT CTTCTTCTTC TT - #CTTCTTCT16140- TCTTCTTCTT CTTCTTCTTC TTCTTCTTCT TCTTCTTCTT CTTCTTCTTC TT - #CTCCTTCT16200- ACTCCTCCTC CTCCTCCTCC TCCTCCTGCT CCTGCTCCTC CTCCTCCTGC TC - #CTCCTGCT16260- CCTCCTCCTC CTGCTCCTGC TCCTCCTCCT GCTCCTCCTC CTCCTCCTGC TC - #CTCCTGCT16320- CCTCCTCCTC CTCCTGCTCC TCCTGCTCCT GCTCCTCCTC CTGCTCCTGC TC - #CTGCTCCT16380- CCTCCTCCTC CTGCTCCTGC TCCTCCTCCT CCTCCTCCTG CTCCTGCTCC TC - #CTCCTGCT16440# 16442- (2) INFORMATION FOR SEQ ID NO:209:- (i) SEQUENCE CHARACTERISTICS:#pairs (A) LENGTH: 51259 base (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear#ID NO:209:xi) SEQUENCE DESCRIPTION: SEQ- GCTCCTCCTC CTCCTGCTCC TCCTGCTCCT GCTCCTGCTC CTCCTCCTCC TC - #CTGCTCCT 60- GTTCCTGCTC CTGCTCCTCC TCCTCCTCCT CCTCCTCCTC CTGCCCCTCC TT - #CTCCTCCT 120- TCTCCTTCTC CTCCTTCTCC TCCTCCTCCT GCTCCTCCTC CTCCTCCTGC TC - #CTCCTTCT 180- TCTCCTCCTC CTCCTCTTCC TCCTCCTCCT CCTGCTCCTC CTCCTCCTCC TC - #CTCCTCCT 240- CCTCCTCCTC CTCCTCCTCC TTCTTCATGT ATTTGTTGTG TTTTAGACAT TC - #TGTGTTTT 300- ACTCATTCAA TCATTTACAG GGTCTGGATT TTCTTATTGT GTGTTTTTTT TT - #TTTTAAAT 360- ACTGATTATA TATAATGGCT GTTTACTCTG TTATCAAAGC TGAAGTATGG AT - #CTGTGCAT 420- TTCTATCCTG TCACTCATCC TCCAGCTTAT CAAGTGTCGT AAGCCATGTG CA - #GACAGAAA 480- AATCCAGACT GAGAGAGTAA GGGAAAGCAC AGTTTAGTTA AATCAAATGA AA - #AATAAAAA 540- GAAATAGAAG TATGCTTTTG TGTCTGCCTT TTAAGCTGCC ACCTGTAGGT TA - #GTGTGCTT 600- TTTCTTTTCA TTAAATGAGA GTAATTTTCT AGTTCTTTAG TTTTGAGTTT TA - #GATAAATA 660- AGGATAAATA AAGATGTGGA TTCCTAATTG AATGTAGACC TGAGTCCTCC CT - #TCCCCATT 720- GGTGTCCATT GCTAACATCA CAGTTTACCA GGGAGCCTGT CTCCTATTTA AG - #AAATATGA 780- GCTAAATCAC AATCTATTCA CTAGGTATCC ATTTTTCTAG TGCATTCAGT TC - #AAGTGGTA 840- CCAAGTGTAG GATGCTTGTA GACATCTGTA CCATATATTA TACACTGGAC AT - #CTCTGTTC 900- TCTGGATATG TTGGTAGAGT TAAAGAAATA TCATCACCTC TTTTTTCCCC TC - #ATTTTTCT 960- TTTATAGGAC GGAAATATTA TACTTTAAAG GACATTCTTA AAACCAAACT AA - #AAAATAGA1020- ACGCCTCATA AAAAGTGAAG ATAACTTGTG TTAAATGAAT AGTCTATGTA AC - #TCCTTAGT1080- AAAAAGTTTT ATAGATACAG CGATTTGAAA TATACTAATA TTTTTGAAAT AG - #TGGAGAAA1140- ATACATATCA AAACACCTTT TTTTCACATC AGTAATATTT CTTTCCTAAA AT - #TATTTGAA1200- TCCTTTTTTA CAATTCCAAA ACACATTTAT TGCTTGCTCA TAATTTAAGC AT - #CATCTTTA1260- CTCAAGAAAA ATGCAATTGA CATGTAACAT AGAGAAATCT ATGATAAAAA TA - #GCATTAAA1320- ATGTTTCATT TTACCACTTA GAATTCTAAA ACGTTGAAGT CCAATAAGAA AA - #ACTGGTTA1380- AATTATGCAA ATTTTAAATT TACGATACGT TTCCCAGAGG CCGTTCATTA TG - #TGCTATTA1440- CTGAACCTTG TTTATGCTGG CCATGCTCCA TCCTGGCCTC GTGCCTTGGA GC - #ATCTTCAG1500- CACGTATTTA TAGAGGAGCA CACATGTTCT TTTGTGCTGT TGTTTGCACA TC - #TGCCGGTT1560- TTCAACCAAA TTGTAGGCTT TGTTAATAAC CCTCCTTTTG TACTCAGTAA AA - #AGATACTG1620- TATTGTCAGT GTTCTGCCTC AAATTTCTTT TAAACTTCCA GTCTTTAGAA AA - #CCTAAATA1680- GTGACATGGT GGAACCCACT CACTCTAAAT GGTTGGAAAT GGGAACCAAT GG - #GTGTCTTC1740- CTCCTGAGGA GGAAGATGGA CACGGAAATG AAGCCATCAA AGAGGAGCAG GA - #AGAAGAGG1800- GTAAGAATCA GGGTGGAAAC AAACTCACCT TTCATGGATT TCGTGTCAGT TT - #TCCCGTGT1860- TTGGAAGTTT AACAAGTTGG TGGCACGTAG TTACTTATCC AGTCTATAAA CC - #AACCACTT1920- AAGTCCTTAG TGCTCCTGTC TCTCGGGAAC TGTGGATGAT GAAACCTTTA AT - #CCTGAAGT1980- GAAAGATTTG GTTTGGGTCC CAATGACAGT GGTGAAATAG TTTACTAATT GT - #TCATATTG2040- AATGCCCTTG TTGGTGATAC AAATACATGC AGTCTGCTAC CCACCAGGAG CT - #TATGGTTT2100- AAACAAGTGC CACACCATAT GTTCAATTAA ATGTATAGAA TAGTAAATGA GT - #GTGCAAGT2160- GATAGAACTG TCATCTACGT GTAACCAATC ATGGTCATTC GGTCAACTTT GT - #AGTACTAT2220- CACTATACTT ACAATATATT GTGGTGGGAA AATGTGGGCA TTTCAAAATC AT - #TTTGTAGG2280- TAGAAGGTAC TTATAAATGT ATTGATGAGT TATTCTCCTT TGTTTCCTTT TA - #TTAAGTGT2340- AGCCATCTGT TTGTTAAGAT GTGCCATAGC ACTTATTTTT CATGTTTAAT GA - #TAGCTTAT2400- CTAGAATCTG TGTTTTATCC TTTCTTGGCT GCTTGTGAAT CTTTGCATCA AT - #GGACAGAC2460- AGTGGTGGGA CTTAGGGAGA GCTAACATAG TCCACCATGT GGTACCATTA AA - #ATTTTTGG2520- CTAAAGATTT AAGTAGCTAT ATTAACCTAA CTAAATAGGA TAGGTAGCTA AA - #TTAGATCC2580- AGGTAACTTA ATTTATATAA CTAGATTTAG TTTTAAACAG CTAAATGAAA AT - #TTTATTTT2640- TTTTCTGTAC ACTTAATTTG GGATACTAAT ATAATTCATG TTTATCATTA AT - #TGAAAATT2700- ACTTCTAATA TAAAATTTTT ATCGGCATTT CTATTGTTTG CTTGGTTCGC TT - #CATTCTGG2760- ATTGTAGATC CTGCAAGTTT CCCAATTACA GGATGTTGGG CCTCTTCTTA CC - #ACTATTGC2820- TAAAGCGGGC CACAAGGATA GGTCTAGTTT GTAAGTAGTG ATCAGAGGAT TT - #GCCTGGTG2880- TCATGCTAGA TATCTGTAGA GTCAAGTGTG ACTGGGATGG AAACAGTGGA TG - #TCACCCAT2940- CACTCTGTTC TTTATCACAG CAATGGAATG AACATTTTCC TCTTCTTGCA TA - #GCATATTT3000- GCTTTTGAAC ATAAATGTCA ATTTTATTAT TTTATTTATT TTTAAGACCA TT - #TATTGCCG3060- GAACCCAACG CAAAGCAAAT TAATTGCCTC AAGACCTATT TCGGACACAG CA - #GTTTTAAA3120- CCGTGAGTAT GATCTCAATT AACTATATTA TGTACATATT TTTTTTTCAC AA - #AGAGAAAG3180- AGTAAATAAT CCATCCCCAT ATCCTAACAG CAGCAGCCTA ATTTTATTGT AG - #GCATATAT3240- GTCAGGTATA GATTATATAC AACTGTAAAA TTATTGGAAA TATTAATTAC AT - #AAGTTTCT3300- TTGTCCTTTT AATAGGAAAG GAAGCGGTTC TATTTTTCTT TAACTGAGTG CT - #TCTATGCA3360- AAAACTATAT AATAATAAAA AAAGAATTTT TCTCACTGCT GAGTTATCTT TT - #ATTGAGTA3420- TGAATTCAGA GGAAAGGCAC ATTGCTTACT GCTTTCTGCA GGTGTTGCAA GG - #CACACTGT3480- TGTGAGTCTC TGAGAGAACA GTTTGAGAAG CTGAAGGTTT ATTGTTTTAA CA - #TTTCAAAA3540- TATATTTCCA TCTAAAGGGC TGTCTTAGTC CATGTCCCAT TGTCGTGAAG GG - #ACACCATG3600- ACTACAGCAA CTCCGATAAA GGAAAACATT TGATCAGGGC TGGCTTACCA GT - #TCAGAGGT3660- TTAGTCCATT ATCATGGAAG GCATGGCAGT GTACAGGCAG ACATGGTGCT GG - #AGAAGGAG3720- CTGAGAGTTC TACATCCCAA TTGGCGGGCA GGAGGAAGAG AGAGTGAGAC AC - #TGGTTGTG3780- GCTTGAGCTT TTGACACCTC AAAGCTCACA TCTGGTGACA TACTTCCTCC AA - #CAAGGCCA3840- CACCTGGTCC AACAAGGCCA CACCTCCTAA TCTGTTCAGA TACTGCCAAT CC - #CTGTGAGC3900- CTTAGGGGAG TGTTTTCATT CCAACCATCA CAAGGGCACA CTAATAACTA GA - #AACAATGA3960- GATGAACACA AACGAGATTA GGAACAAGTG CATTTGAATA AGACCAGTAA GT - #AACTAACA4020- ATCTAGACAG GGTTTTTTCA ATTTTTTTTA TAACTTTTTT TTGGGGGGGG GT - #GCGTGTTT4080- CGAGACAGGG TTTCTCTGTG TAGCCCTGGC TGTCCTGGAA CTCACTCTGT AG - #ACCAGGCT4140- GACTTTGAAC TCAGAAATCT GCCTGCCTCT GCCTCCCAAG TCCTGGGATT AA - #AGGCGTGC4200- ATCACCACTG CCCGTTTTTT GTTTTTTTTT TTAAATAACT TTAAAAAGAA TT - #CATCGGAA4260- CATTTTTCCT TCTTTTAATA AACTATCACC TCCAGTTGAT TTCACCTTAG TC - #CATCACTT4320- TACACAGGTC TCATTTCAAA CCTATAGCAG TCCTCTTATT TATTCTAAAA TA - #TTAACTTT4380- TCGGTCTATA GTACAAAGCT GGGTATTTGT TTTATACTTT AGATATATGT AA - #TAAAATTA4440- CATATACATA CTATATGGCA ACTCATGGTT ATTCAGTCAG TCTGAATGAA AA - #GTTAATCA4500- AATGATCAAA TTTTTTCTCT CAAATTTCTA GGATTTGAAT ATATTTTTAT AG - #GTAGCTCC4560- AAAAAAAAAT CTGAGTTTAT TGGAGAGAAG TTAAATAGAT TTGAACTTGT GC - #TTTGGATG4620- CTATTGATAA AACATTTTAC TTTGTACCTT CAAGGGTTCA GTGGAAAGTC AT - #CCATTCTG4680- TATTAGAAGA GAGAAGAGAT AATGTTGTTG TCATGGCAAC TGGTAAGCTA TA - #CTTAAAGT4740- AAATAATTTA ATCATCTAAA AGTCATAAAG GGTCTAAAGT GCTTAATCTT TC - #AGAAACTT4800- ATAAAATATA GGAAGGAATG ATTGGGGGAA AAGCCTTCAA ACTTATGCAT GA - #ATTACCAT4860- GTCAGTCCAC TTATTCTGCT ATATAAGCAC ACTGTAAGAA GAAAGTAAAG CA - #TCAAGAGT4920- TTCTTTTTAT TTTTTTGTGT TATTTTTTTT TTATTCAAGG ATATGGGAAG AG - #TCTGTGCT4980- TCCAGTATCC GCCTGTTTAT ACAGGCAAGA TTGGCATTGT CATTTCACCT CT - #CATTTCCT5040- TAATGGAAGA CCAAGTCCTC CAGCTTGAGT AAGTAATGCT TGCACTGCTG CA - #GCGTCGCC5100- TTGGATAAGC AAGTGGAAAG AACATGGCAA GGCAGGATCT TACTACACAG GC - #TTAGCTAG5160- GCTCTTCTCT CAGTGCAGTG GCCCTTTGCC CAGTTGTCCC TCTCTGTTCT AT - #CGATGAAA5220- TATCAGAAGA TGAACGTGAA TCTAGGTCAC AGGATTACGT TTTGGGAAGT AA - #CTTGATCT5280- TCTTTATTTC TATTTTTAAT TTTTGAGATA GGGTCTTGAT ATATATATAG TC - #CAGGGTGG5340- TGTCGCTCTG GCCTCTTGCC TTGCCCTTCA TGCCTTGGGC TCACAGAGCA TG - #CACTAGCA5400- CCCCTGGCTG CATTCATTAG TAGCAAACGA AGTGTTAGTG GAAGAGTTTA CA - #TTCATTCT5460- TGAGGTCTCC AATGCAAGGC TACCTGTTTT CTCTGATCAG GGTTTAAAAG GA - #CTGATTGC5520- TTTATGCTAG TTAGCTGTCT CAAATTCTTT TTTTTTTGTT CTGCTCTCTG GG - #CTCCCAAG5580- CTTGCAATGA GATATATATA AAAGTTTACT TTTTAAGATA TGTTTTTATT AG - #TTCTTTGA5640- AAATCTCCTA CATGTTTTGA TTATAGTCAC CCCTCTTCTA ACCCTAAGTT CA - #CCTTTCTA5700- TTCCTTCTTG AAAGATCCAC ATTAAAGACT TGCCTCCTCA TCAGGCTTTT GA - #AGGAATAT5760- ATCAAGTTAT ATAGACACAA AAAGGAAGAA CATTAGAAAG ATGAGGAACA TA - #GGAGGTTC5820- ATGTTTATGT GTGTATTCAT CAGAGCGTTT GTCTCTTGTA GGCTATCCAA TG - #TTCCAGCC5880- TGTTTACTTG GATCTGCACA ATCAAAAAAT ATTCTAGGAG ATGTTAAATT GT - #GAGTAACT5940- TATATCATGT CACATAATAT TGTAAGATGT ATATAGAGTA AGAGAATTTT GT - #ATATATGT6000- TTACTTATAT GAGTAAATTG CCCATATTTG AAAACATACT TTAAAAAGCC TT - #ATTTCTGA6060- AATAATAACA TAGTTCCATT TCTTCCTTTC CTTTCTTCCT TCCAAACTCT GC - #CAAACATC6120- CTTCCTTGTT CTCTTTCAGA TTGATGGATT TTTTTCCCAT TAGTTGTCAT TA - #CATGGATC6180- CATGTTTATA CATATGTATT ACCAAATGCC CCGTTTTTTC TCAGCAGAAG TC - #ATGTAAAA6240- CTCCTTTATC CTTAAGATAA ATATTCACTT TTGGGGGGCT GGTAAGATGG CT - #CAGTGGTT6300- GAGAGCATAC TGAGTGCTTT TCTGGAGGTT ATGAGTTCAA ATCCCAGCAA CC - #ACATGGTG6360- GCTCACAACC ATCTGTAATG AGAAACAAAT AAAAAAAATC CCTATGGGCC AG - #AACGAGTG6420- GGGCCCCGGA GTGAGTGGGG TCAGAGCAAG AGGGAGAGAA AGGGAAGTGG AT - #TTTTATTC6480- ACTTTTTGTT TAAATTATTA TTGTATTTGT ATTATTAACT TGTCTTCCAT TA - #TCTTATTG6540- TATCATATCT AGTATTATAT GTTATACATA TATATCGTAT ATATGTATTT AT - #ATGTATCA6600- TACTTTATAT TATATGGTTA ATTTGCTATT ATGATAATTT TTATAAAAGA AG - #GCTAGAAA6660- TTACTTATGG CATGTCTCTA CCATATAAAA GCAGATAAAA TTAAATTAAA AA - #TTTTAATA6720- TAAAAGTTCT TTAAGTTTTT AATTTATCTA TTCCACTAGT ATTTTAGTGT CT - #ATTACATG6780- CTAAACATTA TGTTTTCACT AGTAATTTAT TAGGCATGTA ATAAATTTTA TC - #GTATCTCC6840- AGGAAATTGA TGCAGTTTTC TAATTACTGT AAGAAACAAT AAAAATAATG AA - #GGCTAACA6900- TCACTGTACC CAGGTTTGGA ATCAGTTCTC CGTCCGACTA GGAAACTGAT CT - #GAGATGAG6960- CCAGTCAACT CCAGTGTATC CCAGTTTCTT GAAAATTAGC TGTTTACTTA CA - #GAGACAGA7020- CTTAGGACAT CTCAGTTAAG AAACGGACAC TGGAACCTTC ATGGAACCAA AG - #AGCAGCCA7080- GGAAAACTAA CACACCCCTG AAAACAAAGA GCATAACTGG GGGCTTGTCA TC - #GAGACTTG7140- CAGGCTTTTA CTGTAGCTAC AGCAGCCAAC ACAGGCAGAC GGAGCCACAG AA - #GCAGATCT7200- CAGCAAGGAA TCTGCACATG CCTACAAAGC TCATCATCTG AGAAAGGCTC AA - #AGGTGATC7260- CAGTGGAAAA GAGACAATCC AGAATAATGG CTTATATGAA AACAATGGCC TT - #ATAAGAAA7320- AACAAACCAA ACAAACCAAA CCAAAACAAA CAAAACCCCC CAAACTAATA CA - #CCACACAA7380- TATAAACATT TTTTGCTAAA AGCGAATTAT GCGTCCAAGC ATAAAATTGT GA - #AATGTTTA7440- AGGAAAAGCA TGCCATCTTT ATAACCTTCA GTTAGGGAGA CTTCTTAAAT AC - #CCAAAGCA7500- AAATCTATAG GAACAAACTA GCAGCTGGAC TTTTACAAAC TGAAAACCTA CT - #TCTCTTCA7560- AAAGAATTAT TGAAAAAGGA AGAAAGGCCA TAAACTAGCA AAGTATATGC AA - #AGTACATA7620- TCCATACAAG ATTTCTACCT ATAATATAGA AATTACCACC AAAAGAGAAT TA - #AAAAAAAT7680- TAAAGTGTCA AAAGATTGGA ACAGACACTA GCACAAAGAT ATACAAACAG CA - #ATAAGTAT7740- AAGATGCTTA TATAATTGGT CACCAGGCAA AAACAAATTC AAGGTACAGT GA - #GATTCTTT7800- CCAAGTGGCT AAAGCCAATG ACTGGCTAAG AAATGTCAGG GGTAGTGAGC AA - #CAAGACTT7860- TTCACACACC ACTTCTAGGG ATGAGAGATG GTAGAATGTT TGTTTGGGGA GT - #AGACTGTT7920- AGAAACCATA ATTTGGCTTA TAATTCCAGC TTAGTGGTGA ATCCTACACA TC - #AAGAATTG7980- TTATATTTTA TTTTGGTGAA TTGAAGATAA ATGAAAGGAC TAACATCTGA AT - #TATGTATA8040- TATATAAAAT ATTCCTTTGG ATTTTAATAA TCAGCATGAT GCATTACTTA AA - #AACCTATT8100- GAATGCTTCT TTCCAGTCTA GGGCAGGGAC CTTAGCTGAC CTTGGGTGCT AA - #CTCTGCAC8160- CCAGCCCCAC AATACCCAAA GGAAGCTCCA CTTCTAGGCG CTCTAACACG CC - #AAGTCCGC8220- AGGATTCCAG GATCCCAGGA ACTTGGTCAC ACCAGGATCT CAGGGTTTTA GA - #GGAACCTT8280- GGCTCCCAGG AGCTCTGACA CACCCAGGAT CTCAGGATCA CAGGATCACA GA - #GACAGCTG8340- AACTCTGAGA AGGTCTGACA CGACCAGGAT CACAGGAAGG ACAGGCTCCA GT - #CAGATATA8400- GTGAAGGCAG GTAGCACTAT AGATAACCAG ATGGTGGGAG GCAAGGGGAA GA - #ACATAAGC8460- AACAGAAACC AAGGTTACTT GGCATCATCA GAACCCAGTT CTCTCACCAT AG - #CAAGTCCT8520- GGATACCCCA ACACACTGGA AAAGCAAGAT TCAGATCTAA AAATCACTTC TC - #AGGATGAT8580- GATAGAGGAC ATTAAGAAGG ACATCAACAA CTCCCTTAAA GAATACAGGA GA - #ACACAAGT8640- AAACAACTAG AAGCCCTTAA AGAGGAAACA CAAAAATCTT TTAAAGAACT AC - #AGGAGAAC8700- AAAATCAAAC AGGTGAAGGA AATGAACAAA ACCATCCAGG ATCTAAAAAT GG - #AACTAGAA8760- ACAATAAAGA AATCACAAAG GGAGACAACG CTGGAGACAG AAAACCTAGG AA - #AGAGATCA8820- GCAGTCATAT ATACAAGCAT CACCAACAGA ATACAAGAGA TAGAAGAGAG AA - #TCTCAGGT8880- GCAGAAGATA CCATAGAAAA CATTGACACA ACAGTCAAAG AAAATACAAA AT - #GCAAAAAG8940- CTCCTAACCC AAAACATCCA GGAAATATAG GACACAATGA GAAAATGAAA CC - #TAAGGATA9000- ATAGGTATAG AAGAAAGTGA AGATTCCCAA CTCAAAGGGC CAGTAAATAT CT - #TCAACAAA9060- ATTATAGAAG AAAACTTCCA TAACCTAAAG AAAGCGATGT CCATGAACAT AC - #AAGAAACC9120- TCCAGAACTC CAAATAGACT GGACAAGAAA AGAATTCCTC CTGTCACATA AT - #AATTGAAA9180- CATCAAATGC ATTAAACAAA GAAAGAATAA TGAAAGCAGT AAGGGAAAGA AG - #TCAAGTAA9240- CATATAAAGG CAGACCTATC AGATATAGGA CTAGACTTCT CACCAGAGAC TA - #TGAAAGCT9300- AGAAGATCCT AGGCAGATGT CATACAGACC CAAAGAGAAC ACAAATGCCA GC - #CCAGGCTA9360- CTATACCCAG CAAAACTCTG AATTATCATA GATGGAGAAA CCAAGATATT CC - #ATGACAAA9420- ACCAAATTTA CACAATATCA TTCCACAAAT CCAGCTCTAA AAAGGATAAT AG - #ATGGAAAA9480- CACCAACACA AGGAGGGAAA CTACACCCTA GAAGAAGCAA GAAAGTAATC TT - #TCAACAAA9540- CCCAAAAGAA GATAGCCACA CAAACATAAT TCCACCTCTA ACAACAACAA AA - #ATAACAGG9600- AAGTAACAAT CACTTTTCCT TAATATCTCT TAACATCAAT GGACTCAATT CC - #TCAAAAAA9660- GGACATAGAC TAACAGACTG GATGTGTAAG CAGGACCCAG CATTTTGCTG CA - #TACAGGAA9720- ATGCACCTCA GTGACAAAGG CAGACACTAC CTCAGAGTTC AAGGTTGGAA AA - #CAATTTTC9780- CAAGCAAATG GTTGTTTCCC AAGAAACAAG CTGGAGTAGC CATTCTAATA TG - #GAATAAAT9840- TCAACTCTCA ACCAAGTTAT CAAAAAAAAA AAAAGATAAG GAAGGACACT TC - #ATACTGGT9900- CAAAGGAAAC ATCTGCCAAG ATGAACTCTC AATTCTGAAC ATGTATGCTA CA - #AATGCAAG9960- GGCACCCACA TTCATAAAAG AAACTTTACT AAATCTCAAA GCACACATCA CA - #CCCGATAC10020- AATAATAGTG GGAGATTTCA GCACCCCACT CTCAGCAATG GACAGGATCA CG - #GAAACAGA10080- AACTAATCAG AGACACAGTG AAACTAACAG ATGTTATGAA CCAAATGGAT CT - #AACAGATA10140- TTTATAGAAC ATGTCATCCA AAAGCAATAA ATATACCTTC TTCTCAGCAC CT - #CATGGAAC10200- CTTCTCCAAA ACTGACCATA TAGCTGGTCA CAAAACAGAC TTCTACAGAT TC - #AAGATGAT10260- GGAAATCATC CCATGCACCC TATCATCAGA CCACCACGGC CTAAGATTGG TC - #TTAAATAC10320- CAACACAAAC AACGGAAAGC ACACATACAT ATGGAAGCTG AACAGCGCTC TA - #CTCAATGA10380- TACCTTGGTC AAGGCAGAAA TGAAAATGAA GACACATCAT ACCAAAACTT CC - #GGGACACA10440- GTGAAAGCAG TGGTAGGAGG AAAACTCATA GCTCTAAGTG CTTCCAAAAA GA - #AACTGAAG10500- AGAGCTTACA CTAGCAGCTT GACAGCTCAC CTGAAAACTC TAGAACTAAA AG - #AAGCAAAA10560- ACACTCAAGA GGAGTAGACT GCAGGAAATG ATCAAACTCA GGGCTGAAAT CA - #ACCAAATA10620- GAAGCAAAAA GAACTATACA AAGAATCAAC AAAACCAGGA GCTCGTTCTT TC - #AAGAAATC10680- AACAAGATAG ATAAATCCTT AGCCAGAGTA ACCAGAGGGT ACAGAAACAG TA - #TCCAAATT10740- AATAAAATCA GAAAGGAAAA AGGAAACATA ACAACAAAGT ATATCTTAAA AT - #AACTATTC10800- TGTTTGTTGA ATATCAATAG TTGAAAATAT TAAAATCATG TTCTACAAAC AT - #CATGGAAA10860- TATTATTGAT AATTTTTCTC ACTGTGCTTG AAATTAGCAT TTTCTTAATG TT - #TATGTCAA10920- AGTGTTTTTG CTATTTTGAA ATGTTTAAAA TATACTTACT GATAAAATAA TT - #TCTCTCCT10980- AGAAACACTG ATAATCTTTT TTCTGTAAAC TGATTTTTGG ACAATGTACA CA - #GATATAAA11040- ATGTGTTTTA AATACTCTCT CACTATGTCA GGTGTTATTA TATAAAGGCT TT - #CAAATATA11100- TTTCTTAGTG ATTCTTTTTA AATATTTTAT GCTCTTTTAC TATGCCTAGC TC - #CCAAAGAA11160- TATTCTGTAT GTTTTGAAAC AATTTAGTAT TCAATATTAG GTACAGGATC CT - #CAGTTATG11220- GATAGTATTA AATATTAATT AATGATATTT TTAGGATATG AAAGGATATG AA - #TATAAAAG11280- TTGGACAAAA TTTTAAAGTA TTATCTGATA TCAAAATACT CAATATTATT GA - #TATGTTTG11340- ATGTATAAAA TACATTTAAA TAATAAGTTT TAAAAAATGT CTATTGAACA TT - #TTGATTTT11400- GTTATCATTC ATTGACTGCC TTTTTTTCCT ATTAGAGTGT TTCAATTTAT GT - #TTCTATTT11460- TTGTTTGTCT TTACAGAGGC AAATATAGGG TCATCTACAT AACTCCAGAG TT - #CTGTTCTG11520- GTAACTTGGA TCTACTCCAG AAACTTGACT CTAGTATTGG TAAGTAATGA AG - #TAGGACTT11580- CGGTGAATAC AAAGTAACCC ATTTATGGTT GAAGACCAGA TTCCAGTTTT GT - #TAAAGGCT11640- TATTTCAAAC ATTTGCTCCT CTAGGAAATT TCTAATCAGT TTTACATTTG TC - #CCATTTTA11700- CAATGCTGTA TAATTCCTCA TTCCATAGAG GTGGTACTCC TGGGTGGGTG TC - #ATATTTGT11760- ATATAAGCAT GTATGTATCC CTGTCACACT CAACCCTTTT GAGGCTTCTC TG - #CTCTTACT11820- GGCCTCCCAA CTCCTTCATG CAGGATGTGG CACACAGTTG TCTATCCTGT GC - #ATTGCTGC11880- ATGAACGCTG AGTCTTGTTT CATATTCTGA GTCTAAATGA AATCAGTGTG TG - #GTTCCTCA11940- TTCTTGCTCG TCAGAATCGC CCTTCAAGCT CTAGAACAAT GCTGTTAAAT GG - #CGTATTTC12000- TTAGAAAATA TAAATATAAA ATAGGTTAAA TGCTGTGATA TTGTTTATGC TG - #AAACTTTT12060- GTTTTTTGGT GGTGGAAGTG TGGTCAGGTT TAGCTAAGAG CTCCAAAGGA AA - #CAAACATT12120- ATCCATATTC AAAACTTTCA TTTAAATTTT ATCCAACTTA TCAGATAAAA TT - #GTTTTCCC12180- AATTTGTGGG ATTTTCGTTT TTGAAGAATT AGGTATTAAG TAATTTCATA TA - #GGTTAAGT12240- TTTCAGTATT GTACTGGACT AGCTAGTGGA GTGTCAACTT GATTTAAGCT AT - #GGTCTTCA12300- AAGAGGAGGA AACTCAGTTA AGAAAATGTC TCCTTAAGTC AAGATGAAGG CA - #ATCCTGTA12360- GAACATTTTC TCAATTACGG ATTGATGGTA GAGGGCCATT GTGGATGGTA CT - #ATCTCTGG12420- CCTGGTGGTC TTGGGTGCTA TAAGAAAACA GGCTGAACAT GCCATGGAGA GC - #AAGCCTGT12480- AAGCAGCATC CCTCCGTGGG CTCTGCATCA GCTTGTATTG ATTGGTGTTG CT - #TGTTGGTG12540- CCACAGTAGA GAGAGGAGCT CACCAAGTTC CTAAGCCATC CTTTTTGGAA GG - #AGCAGAGG12600- GGTTCAGCCT TCCTGGGAAG GCTCACTCCA GTTACTTTAT TCAAGCATTG TT - #CAAGGTTA12660- ATTGGGGCTG GGAAAGGTTT CAACCACCAC AGTTGTTATC TTGTGTTTGC TG - #CTCAAGAG12720- ACAACATGAC CCACACAGAT CTTAGTCCCT TTTGACCATG GCTAGGCATA AT - #CAAAGGTA12780- AGAACTCCAG GTTTGCCAGG AGTGTCTTAG GACCAAGGTT GATGCAGCTG CA - #GGCCTTCA12840- GGTAGTACTG AGTGCAGACT TTGCAGGGAG ACAACATTTC TTCAAATAAT CT - #CAAAACAA12900- TTTCTCAGCC TCTACTCATT AACCCAAACA CAGCAGAGGC TTCGCTGAAA CA - #TTTCACTC12960- AAAGCTAGGC ACAAAGGCTT CACTGAACAT TTCACTTCAG GCTCCTGCCT CC - #AGGTCGCT13020- TCCCTGCTTG AGTTCCCACA TTGGCTTCCA TCAATAATGA GGATGATGTG GA - #AGTGTAAG13080- CCAAATAAAC CCTTCCTCCA CAAATCGCTT TGGTCATGGT AACAAAGACA TG - #TACCCTAT13140- CACTTAATAG TATTTCTCTT ATCAGGCATC CATGGGAGGA GGGGCCCTTG GT - #CCTGTGAA13200- GGCTCCATGC CCCAGTGTAG GGGAATTCGA GGCTAGGGAG GCAGGAGTCG GG - #GGTGGGGG13260- GAACACCCTT ATGGAGGCAG GGGGATGGAG AATGGGACAG GGGATAACAT TT - #GAAATGTA13320- AATAATGAAA ATATCCAATA AAAATAAATA AATAAATAAA TAAATAAATA AG - #GAAATTGA13380- AAAAAAAAAC AAAACAAAAA GAGAGTAGAC TTTTATATTT CAGTATGTGT TG - #AAAGCAGC13440- AAAGAATGAG GACCTACATT AATATTTATG GAAATATATT ATCACAGTGT AC - #CTATGCTC13500- TCTCTCTGTT AGCTCTCATT GCCATGTTTT TGCCTGTAAT GGAAAACAAG TT - #TGATGTCC13560- AGTCTGTAAT AGCTGGAAGG TGTTCCTTCA AGCATCTCTC TATGGGTTTA GC - #CTTATAGA13620- TTTACCTTAT AGATCTATAG CCTTATAGAT CTACCTTATA GGTCAATTTC AT - #GGTTGGAT13680- CTAAAAACCT GGTTATCAGT AACTCTGTAT TCTGAGTATA TTTTTTTCCA CT - #TTCAGTGT13740- TTATTTGTTT TAATTTATAA TGATGTTAAA TTAATAACTC CTGTAAGTAA AT - #AAACATTA13800- AGAGCCTTTG ACAAGTAGTT ATAACTTTTT ATGAGGTAAA TGGTCATTGC TG - #CCGAGCTG13860- AGGACACTGT TCAATGATTC TGTTTGCCTA GCATGTTCCA GGCCTGGCTT CA - #AACCTCAT13920- TCAGTTTCAC TTATTTTTGT TTTTACTCCA TGTGTTGGTG TTTGTGGTCA CA - #GGGTAACT13980- TGAAGGAGAA GGGGAGATGG TCCTCTCCGT CAACCATGTG GGTTCTGGGC AT - #TTGCTGTT14040- ATGCCAAAGG GAAGTGGTTT TACCCACTCC CTCTTGCTCA CCTTAGACAC TG - #TATGTTTT14100- GTTTATTGTG CTTTTCTCCC CCCCCCCCCG TGAATCAGTT TAGGAGAATG AT - #ACAGGAGG14160- ATCAGATAGT CTGACCTCCC TTCTGTTTTA AAAACATACA CACAAGTGAG CA - #AACAAAAC14220- CAGATAACAC GTGTAAGTTT TTCATCACTA GAGCAGAATT GTTTGCTTTT AA - #TAGATAAA14280- AATATTTCCC TGGGTGATTT AGAAAAAGGG ATAAGGAAAA TGAAAATTAT TT - #TTTTTAAA14340- TATTTCCACT GGCTTTTGTT TGCAGGAAAC AGTAAAAAGT CTACAAAAAT GA - #ATATACTT14400- GGGATGTTAT TTGTACAGTA GTCTGACATT TAACTAATCA GATTTGTCAT TT - #TTAGGTAA14460- ATGTTACATT TTTTTTTAAA GTAGTCCGGG TCTATAACAG AAATAGCAAG CA - #TACTTCAT14520- GGGGTGCCTT CCCAGGCGTA CTTGTGATTG TCTTTTAACT TTGGGAATGA GA - #CTTGAATG14580- GCAGATGCCT AAATGAAATC TCTACAGGAC CTTGGAAGAC CCTTGAACTT TT - #GCATTCAG14640- AGTGAATTTT GCCAAAGCTT GTCTGAACTA ACTGTGTAGG TGAAAGTTCA AC - #TCTATTAA14700- CTGCTTGTCA GATCTCTTTT AACTTAAAGT CTAGCCATGT TAATTTCTAC AT - #TCAGAATA14760- AGTGTATGAG TGACACTGGA ATTTCCGCAG TCACTCAGTG GTATAAAGTC AG - #CGTTTGCC14820- TCTTCGCTTC CTTCCTTCTC GCAGTCTGAG GACATTGGTG TAATCTCAAT GA - #GTTGCTCT14880- TGTTTCTTTT GTTTCCTCTC TGGATTGTGA GACCCTTGAG GTCAAGTATA CT - #TTGGTTAC14940- CAAGAAAAGG GTTAATTCAG TTTTCTTATT TAGATAGAGC CTCCAGCAGC TC - #AGGCCGGT15000- CTTGAACTTT CTATGTGGCT GAAGAGAGCC TTGAATTCCT GATCCTGAAT TA - #CATGCGTG15060- TGGCTCTTAA AAGGGCTTTA AATCATAATG ACCATGTAGT AATAACCGCT GA - #AGTATATT15120- TTTATTAAGC TCTTTTTGGG CCCATCCTTA TCTGAGTGTT TTATGTGAAT GT - #TCTAATTT15180- AACCTTAGAG GAGTAAGAAG TATTAGGTGC TGTTACTACC TACCGTGTTT TA - #TTTTTGCT15240- TACGATGCTG TTTGTGCTGC TGGTGCTGCT GGGGGTGATG GTGGTGATGG TG - #ATGGTGAT15300- GGTGGTAGTG GTGGTGATGA TGTTTGTGGT GGTAGTGGTC AGTGTGTGTG TG - #TGTGTGTG15360- TGTGAAATAC CACAGTGTGT TTGTAGAGGT CAGAGAACAC CTGTGTAAGT GG - #GAGACAGT15420- TCTCTCTGTG GTTTCTGAGG GTTGAACTCA AGTTCTCAGA CTTTTACCCA CT - #GAGCCTTC15480- TCAGCAGGTC CACGATGTAG TTTTGAGGAA ACTGAGAACT GAAAAGATTT GT - #AGCTTGCT15540- CAAGGCTTTG TGTACAGCTA ATCTAATTCT AAAGCACATG TTTTAAATCA TC - #TCACTGAT15600- AGGGTATATC AGCAAATAAC AGAAGGTTAT TTTTCTCTTA AAAGTACTAA TT - #TGATAAGG15660- GTAAAGGCAT TACTAGTCAG TTCTTTGAAA TGTCTGAAGA TGTCATGATG AT - #TACATAAT15720- GAAGCCCTTT CAGATGCATT AAGACACCAT TGATCTTGTA TTAGTGTGTG GT - #GTGGGGCC15780- CCGTGGAGGG TTATGTTCTT TTTCACTACT TACTTTGCAC ACGGTGGGAA TT - #AGTTCTCC15840- CCAAGCCGTT TTATGTTAGC CAATGTGGAT GTCATCTCGT CTTCAGTTAT TG - #GCATTTCA15900- GAGGAACTTC CTGTAATATG ATATGTGCCG GATTGCAGAT AACGATGTAC TT - #AATCTCAG15960- TAGAAATGTG CTGACTATTT GTCTCCGTTG ATAGCTAATC TATGAGATAA GA - #TTAACATT16020- ATTGCCAAAA AGAAATGGAA CAATTCTTTT GAAAGGATAT TGTTGTAGAT GT - #TATAAGTG16080- ATAATTTTGG GACACAGTAA TAATAAGCAA TTTATGTCTT TGAGGAATAG TA - #ATGAAAAC16140- TGAAAGATAG TGTGTTGTTT CAATTACGAC GTAAATATTT CCTGTATGCG AA - #CCTCTTTT16200- ATTCATTTCT CCTCTTACCT CCTATTCTGC CTTCGGAAGT TTGATGTTAT CT - #GGTATTAT16260- TTATGCTTCT TATATGTGTG TGTGTTTGAG CCCAATACTT TGATTTGACT TA - #TACTTTCT16320- GTGAGGTATA TGTTCTAATA GGAACAGACA ATATTGACTT AGCTAGCATT TT - #CCTTCTGA16380- GCCTTATTTC TCCTGTATAT TTTCTTCTGT GTAGGCATCA CTCTCATTGC TG - #TGGATGAG16440- GCTCACTGCA TTTCAGAGTG GGGCCATGAT TTCAGAAGTT CATTCAGGAT GC - #TGGGCTCT16500- CTTAAAACAG CGCTCCCATT GGTAAGCCTT GCCAGATCTC ATGCCCCCAC CC - #CACCCATC16560- TCAGCTGAGG ACTGACCCCA GGGCTCCTAC CACCAGGCTA GACCCTCAAT CC - #CGAATTTA16620- CTGAAGTGAC ATTTTCATCA AGGCCTTTCC AGGACTGGGT AATGTCCACC CA - #TCTCAAGA16680- CTTCTCTATA AAAGGGATCA GATGTGAGCA ATGGGGCATA TTTAGTTTTA AA - #ATTTTTTA16740- AATTCTCACG CTGGCTTCCT TTTGAGGTTG ACGTGTAGCT TACTAAGGAA TA - #CTCTTAAC16800- AGGAGTGTCC AGGCTGTGAC ATTGAGCTAC TCCAGTGTCA TCTTCAAGGT TC - #TCCCTCAA16860- GAACCACAAA ATTGTGTTAT TCAAAGACAT CACAAAGATG CCTCTGTTTT AG - #TTCACGTG16920- TGACTTTGTG TTGTGCCACA TTCCTACTGT CAGGGCACGG GCTGGATGCT CT - #TCACTAGG16980- ACAAGAGCTG GAAAACAAGT TTTGAACATG GCAGATAAAA ATGGCAGTTA CT - #ATTCCTTA17040- GTGAAAGGGG ATACAGTTTC AAGAATCCGT GGATGCCTGG AAACACCCCC TC - #AGTGTAAA17100- TTATGCACAG TAGAAGAATT TTTAAAATGA CTATCTGTGA CAATATACTA TA - #GCAAAAAT17160- GACCACAGTC ATTATTCTTG ACCGCGTGGC TCATGATTAA GTAGAGTAGG TA - #GCACCCAA17220- CCACAAGCAC TTCCTAGTCT CCTAACTGAG ATGGTTAGTC AGTAGGTAAT GG - #GGGAGGCT17280- GTGGATTGTG TGGAAACTTT GGACCAAGGG GAGAATGGGG TGATATCTTT GA - #GAGTACAG17340- TGCAGAATTT CATCATGTTA CTCAGCACGC CTTTAATCCC AGCACTCGGG AG - #ACAGAAGC17400- AGGTGGATCT CTGAGTTTGA GGCAGCCTAC TTTAGTCCTG TCTTAGGAGA AA - #GATAAAGG17460- AAAATGTAAG TTGGGTTTTA GGTTTTTTTG GTTTTTTTTT TTTTCTATTT GT - #TTGTTTTT17520- GTTTTGTTTT TTGTTTTTTG GTATAACTTT TCATTTAGTA TATTCAGATT TG - #GTTGTTCA17580- CAAGAATCTG AAATCAGAAA ACGCCATTGT GGATAGAGAA GGTGGGTGTG AA - #GTGGATGA17640- GAGGGCGGGT GTGTGGTGGA TAGAGATGGG AGTGTAGTAG ATGGAGGGGG CG - #GGTGTGTG17700- GTAAATGGAA AGGGCGGTGC GTAGTATAGT ATGGCTTTCA CATACAGTTC TC - #TTTTCTTA17760- AATAGTCCAT AAAAAATGTA GTTACCTGGT GTTCCTCACT AATGGCCTCT GT - #AAAATGGG17820- CTGGGGACTG CGATAGTTCT ACTTATCACA GTTTGTAGAA ACTTTTAGGT TG - #TTTGTTGG17880- AGTTAGGATA TTATGAATGG GGATACTGTA AACATTTGTC TATAGTCCCA GG - #GTCCAGGT17940- CAGCGGTTAC AAAGTTTGTG AACATAAGTT TTAGTTTTCT GGGATAAATG AT - #GTTCTGGG18000- TTCTATGGGA AGTGCTGGTT TCACTTTTAG GAAGACCCCA GTGCTACTCT CT - #AGACTGGC18060- TGCTCTGTTT TGTATCGTCC CCTCCCCAGC AGCTTAGGAA CAATAGCTTC TT - #CTCTTTTT18120- TGCCACTGTT TAGTCTTATT ACTATGTAGT ATTTTAGCAA TTATGATACG AG - #TGGAGTGG18180- TAGCTTGTGT TTTCAATTTG CATTTCTCTA ATAGCTAGTG GTGTTGAACA TC - #TTTTGTGA18240- GCTTCTTATT TGGTTAAATG CCTAGTTTAA TTGGGTTGTA TTTTTTCTGT TA - #AGCACATG18300- GGGGAGGTGG AGGGAGAGAA AGGGAGGGAG AGGGATAAGG AAGGAGAGGA GA - #GAGAAGGA18360- AGGAGAGAGG GAGGGGGAGG GTTGTGCTTA TGCACATATA CCTCTGCGGT GT - #GCTCTACA18420- GTGCAGCCCC TGCAGGCGCC AGATGTTGAC GCTGCTGTCC TCCTCTGTTA CT - #CTCTACCC18480- CATTTTATTT GAAACACAGT CTCAGTAGCC AGGGAGCTCC TCATTTGTGC TA - #GACTAGCA18540- GGCCACCAAG CCCCTGGGCT CTTCCTACTT TGGAACATTG GGCTCCTAGG TG - #TGCACGCT18600- GTGCCTGGCT TTTCTGTTGG TTCTGGGAAT CCTTGCTCAT GTCCTGATAC TC - #ACTGAGCC18660- ATCTCTTCAG TCCCTCTGTT AACTGCTAAG AATTAAATGT TTATAAGTGT GA - #GTTATTGG18720- TTGGATATTG AGCTTGTAAA TATTTCTTTG TAAATTTTAT TTTTTTCTCC TA - #TTTTCACA18780- ATCTTTTATA AAAAATATTA TAAGTTGGGT AAAATTCAGA ATATTTTTTT TC - #CTTTATGG18840- GCTTTCTTTC TCAGTCTCAG ATCTTGAAAG TTTGTCCCTG TAGTTTTTCC TA - #AAATGTAA18900- ATGATGTAAA TTTAGGTCCG ACAGGGTACA GAGATGTCAT GGCAGGTAAA GA - #GCTTGCCG18960- TGCAAGTGTG AAGACATGAG CTTGAGTCTG TGAAGTACAG TGACATGTGC CC - #CATCCCAC19020- ACTATATGGC AGAGGAGACC CAAGGGCCCA CTCCTCCCCT AACTGGGTAA AA - #AGAGGGCT19080- TTTTATCTAC TTAATTGCTT TTGCCTCTTT GTTGAGAATC TTTTGAGTGT GT - #TTTGTCAG19140- CCTGTTTCTC TGGGCTGTAG TCATTTGGAT TGAATTAACG AAGCGGCCTA TA - #TTTAGGTC19200- CTGGTGCTAG AGAGACGGTG TGCACAAGCC TCACAGTTAA ATGGGTCAAA CC - #AAGAGGAG19260- CATTCAAAGT TCTTATCCTT TTGGCGAGAT TGTCTGACTT AGTTCCCTTA AT - #CATCAATC19320- TTACACATTA ATAGCAAATT GCTATGTTTA AAATGACTTC TTTCTGTTCG GG - #TTTTCTCG19380- TCAAGATTTG ATTGAGCAGT GATTAAGTAA GTCAAAAACA GTAGGAGACA GG - #TAATGCTA19440- CAGCTAGCAG ATACTACATC AAAGGAAAAG AAACTAATGT ATTTGGGGTC TA - #AGTATGCG19500- TCTGGCCTTG GGTCAGACAC TCTTGTCTCA GTCTTCAGGA CTGTTAATTA AG - #TTAGCTTT19560- AATGCCATCA TATTTCATCA TTTGTCAAAG GACAGCTCAT TCCCCTTGCT TT - #CTTTCCCA19620- GCATAACCTT CTCCTCAAGT CTCTTCTGTT CCTTTGTACC TTCTTGTTTT AT - #TAGGGTTG19680- GTGTCCTGGT CCCTGTTTTA GACTTACTCT CTCTCTCTTC TGTGCTCTCT TT - #TCTGTGCA19740- TAATTGGATA CCATCCATCC CATTATGGAG AACCCTCAAA TCTACAACTT GG - #ATTAGTAC19800- CAGATGTGAC TGAGTTCCTC CGCCTACTTA CCGGCACTTG CTGTTGTACT AC - #ATTTTGTT19860- TTAGCAATTT TATTGCATAT AAATCACACA TATTATAGGG GATTTATAGG AT - #ATGTATAT19920- ATACACAATT GTCAACTTGA GGGTTTGCTC TTTGGGTTCC TAATAGGTAT CT - #CAAACTTA19980- ACCCCTCCAA AACTGGCTCC TGATGTTCTT CGCACTCTGA GTGCTTTTCC CG - #CAGACTCC20040- ATCACCTTGT TTAATAGCAG CACCAGAGTG TTTTGCTATG CAGCCCGGAC TA - #AACAAGAG20100- ATCCTCCTGC CTCAGTGTAC CCAGTTGCCT GGAATGCAAG TGTGTACTAC TC - #TGCCTGGG20160- AGCTTGATTA TTGTTACCAC TCTGCAGCAT ACATTTCACC AGTAAGGAAA GC - #CTGTGAGT20220- GATCTTCCGA GCCTATACAG CTGCTAATCG CTTCCCTCTT GATCCCTGCC GT - #AGCCCCGG20280- TGCTGGCTTA CATCTTCCTT CATGTAGGCT GTTACAATAA TCGCCTGGTT TC - #CACCTTTA20340- GTCTATTTCT ATACAGCGTT CAAAGTGATA CTTCTGAATC TGTCCCCTAG TT - #CTGTGTCT20400- TCTGTGCAGG ATGTGATGGC ATCGCCCCTC ACTGAGGTTA TGCTATGTCG TC - #TTTCACTT20460- TCATGCCCGA ATGGTGATGT TAGCTTCTTA ATGCAATCCA TCAGTGAATT AA - #GTCTTTGG20520- GTCAGGTTAC AGCCATCGTT ATCTAATCAC CTCTCCGTGG TTGGGTCTGT GA - #CTTGGGGA20580- TTTTCACCCT TCTACACACA GAGAGGGCAG TTTGTATCTA AACCATAACA AG - #AGGGAGTT20640- TTTCTTTTTC TTTTTGTTTA TATAAGCAGG GGTACTATCT GACTCATAGC AG - #TTGCTTAA20700- TAATTACACG AATCAATTAA TTCTGGTCAG AAAGCTGGGA ATTAGCGAAG TA - #ACTTTCCT20760- ATATAGGTAG TTATAAAAGA GTTGGGTAAT AAATAGCTAT ACCATAATAT AC - #TGTGCCGA20820- TTTCAACACA AATGATTTGA AAGAGACAAG CTATATTTTC TACCCTTAGG TA - #GTTCATAG20880- CCCCGAGAGG GAGTTGAGAT CCACATCCAG GAAAGTAGAG GCAATAGAAA CA - #AACTGTGC20940- ACCATGCATG GAAAGATGAG TAGTGCCCAT AGCACAGTCG CACATGGGAG GG - #CAAGTGAA21000- GGTGTCCCAC AGTGCAGTCA CTGAGCGCTG CTCTGAAGGA CTGGTTCCCA CT - #GACTTAGG21060- AAGATTTAAT GAGACAGAGC GAGCTGTGGA ATTGAAAAGC AAGAGGATGC TT - #GTGTAAGC21120- CTTTCTTAGG CCTTTGATTC TAGGATTGCG TTAAAGGAGT TTTAAATAAT TT - #AAGTGGTT21180- CTCAAATATT CTTCAGGTGG AAAAAAAAAG AATTAAATCT TTTATTATAT CT - #AACTCTGG21240- ACATAATGAG ATCGCTTTCA GTTCTTGCAG TGATGAAACA GCGTATTCCT TC - #AGCTGAGA21300- GTCTTGGCAG GTTGTTCCTC CTGCAGAGGC CGAGGATCCT TAGCCCCTGT GC - #TTTTAAAG21360- ATGGACTCTG TTGGGGGTGG TAAGAAACGC CACCTGGTGG ATATTCCTTT TC - #TTATTGAC21420- CTTGATCTTA CTGTTTTAAC CCTGTTATGC TGGGATTACT GTTGGGTTCA TT - #ACACCAAA21480- TTAGTATAGC AAATCTAAAA GTGCTGGAAA CCACCAAACA ATTAACACAG AG - #GACCCATT21540- TGGAAGGAAT CACAAAAGTG AGCCCAGAGA GGTGAAAGCC AGGTGAAAGT TC - #TGCATAGC21600- CGTCAAAGTT TATATCTAAC CAGGAGGACG GACTTTTGAA GACTATGAGG TA - #TATTGACT21660- CTTCCCACTA ATTTGTCGTA AGGACCCATT AAAAAGATCA GAATAGTAGA CA - #CTAAATAA21720- CTGGAAGAAG AGATTAACTA AAATCTGTGT GCAGAGTGTG AAGTAGTTAT GT - #CATCCAAT21780- TTAGAAAAAA GATTGTTATG TTTTCTTTCA ACCGTTGTTT CATGGAGCAT GT - #AGTTAAGA21840- TTCATCTCAA TGTACAGTGT CATAAGATTA ATCTGCATTA TATATTCATT GG - #GTTTTGTT21900- GCTTACTTTG TCAACAACTG GTGTCTCTTA CCAAGGAAAT CAAGGCAGGC AA - #ACTTAAAG21960- AACAAATTCC TGGTGCTAAG TGCTTGATAT ATGTAGACAC CAGTATAATT CA - #GCACATGA22020- CCAGCTTTCT TCTCAAACAG GTTACACTAT TTATAATTGT GCTGTAGCCA CA - #AAAACGAC22080- CTGGAAATAG CCCATCCAAC AAGGGCATAT GGTCCCATTT CTCAGTACTG AC - #CCATGTGC22140- TATTTGTAAG CATTGTCCTT GACTAAAATT TTCACATTAT AAAATGCTGC AG - #ACTTCTGA22200- GGGATCCGTT CTAGTCACAT TCATTTTCAT GAAGACTGTT ATTTTTTATT CT - #ACTTTTTA22260- GTTGGAAGAG CAGTATTCCT CTCTGTGTCT TTGGAATGTT GTAGTGAGTT TA - #CAATATTT22320- TCCCTGCTAG CAGTCTGCTT GACTTTTTGA GGACCTTATA AGAAAAATGA AA - #ATTTTTAC22380- TAAAAGATCT ATCAATCTTG TAGCTCTGTG TCTCTCACTT CACTTTTCCT TA - #AGTTGAGC22440- CCTTGCTGGA GTCAGTGGGG AATGCGCTAG CATTTGAAAT TCTCCACCAT TG - #ACATTTCC22500- ATGCAGAAAG AAATGTCTTC TGTTGTTTTG TGACTGCACT AGTTATAAGG AA - #CATTTTAG22560- GTGCTGGCTC TAATACCCTG AATAGAATTA AGCACTTAGC ATGCTTTTGT AG - #ATATGTTT22620- ATGTGTTTTG TGTGGAGTCC AGGTGTGTAT AAAGACTACA GGTCATTCTT GG - #GTGTTGTT22680- CCTCAGGTAC AATCCACATT GTCTTTGAGA AACAGGATCT TTCACTGGCC TG - #GAGCTAGC22740- CAAGTAGGAT GGAGTGACTG GCCCTAGAGT CCTGGGAACC TCCATATTTC TT - #TTATATTT22800- GGCATAAGAC CGCTGTCCTT TTTCTTTGAT TCTTAAAATA TTGTTCAGCC TC - #TTTGCTTA22860- TGCAAAGGCG ATCTATCAAT CAGTAAAGTT CTGGCCTGAG AAGTCTGTTC AG - #GAAGACAG22920- GCCATTGGCT GAGATCATCT ACCCAGTGCC GGTATTACAA ACTGGAATTT CA - #AGTGTGTG22980- TCACAACATC TAGGTGTGTG TGTGTGTGTG TGTGTACACA TATATATGTA TA - #TATGGTGA23040- TGCCCAGCGT CCTGAAGGCG CTGTTTGACA AAGTTCCAGT TCTTGGACCA AG - #CCTTCACT23100- GCCCTTGGTG GATATTCGCT GCACACCTCT TGCTAGTCTT ATGTTTCTCA CT - #GTTAAAGG23160- CCTCTCTCTG AAAGCTAGAG GTGGGATAAC AAGAAGCTAG TGTAAACAAG AA - #TCAAGTTA23220- ATTAAAGTTC CCTGGGGGGG GGGAAGTTAT GCAGAAAATT GAGTCTCTTC TA - #AGAAGTTA23280- TTTCTTAAAT AAACATTTAG ATCATTAATG AATGTTGTTA GTAAGCATGA GA - #TAGAAGAT23340- TTGAGAAGAA TTATTAAAGA AGTAAAACTT AGGGAGAACT TAGAAGTTGA GA - #AGTTGTAT23400- TTGGATTGCT AGGTTTTTAA GGTTCAACTT GAGAAACGAG CAGTTTGTAT GT - #ATAGGACG23460- GGATTTGGAT CATGCAGGTT TATGACAAGC CTCGGTGCCT TCCTGAAGGC AA - #AAGTAAGC23520- AGGTTTAGGA ACCCTGATGT TCTTCTGTTC TTCACAGAAT TGTTGTAAAG AT - #AGGGATTG23580- TATTGAAACA AGGGTTCAAG ACAGAGACAC AGAAGAAGGC ACTCTGGCTC AG - #TGAACTAC23640- CTGCCTTCCT GAACATGTAA GGTTAAAAAT GTAAATTCCT AGGAAACTGT TA - #TATTTCTT23700- TTTAAAATGT TAGGTTTTGT TTGTTTGTTT GTTTGTTTTG TTTTTTAGTT TT - #AGTTTTAC23760- TTTTTTTTAG ACAGGGTCTC ACTGTGTAGC TGGGGACAAG CTCCACCCCT GT - #TCCCCTTT23820- TCCTCACCCT CCTGAGTGCT GGGATCACAG GCGTGTGCCA CCACCCCTGT CA - #GGGTCCTC23880- TACACACCCA GGAGTCCTTA CTGTCAGGCT GTGTCTGTTA TCGTATCTTA TA - #TCAACCAC23940- TAATCAACCA TTGTAATGCT TGATTAGAGA ATCTGATTTC TTCAAAACAA AC - #AAGGCTCT24000- GCATGACTTA ATCACTACAT ATACATTCCT AACGCAGAGA GCAGTCGGAT TA - #TTGGCCTG24060- AAGATTAATG TGGGGTTACA TTTTAAAGTG GTTTCACAAA TTTAAAAATA GA - #CAATACAA24120- AAAATTATCC TAATTACTTG GTTTCATTGA GTTTATTTTT GTATGACTTT GG - #ATAGGTTT24180- TAATCTAATT AAGTTATTTT AATCGTAAGA GTAGCTGTTT CTTAATTAAT TT - #ACTGCTGA24240- AGACCAAACC CAAGGCCTTG ACAGGCTCGT ACATTCCCAA TGAGCCATGC CT - #TCAGCCAC24300- TTAACTATTC CTTTCTGTGT GTGACTGAAA ATAAGCTTTA TTTTTCTAAG CC - #AACAAAAA24360- TGAAATAATG CTTGAAGCTT TGTCCAAGTC TATATTATTT TATGGGTAAT AT - #TTATTTTA24420- TATTGAACAC TTTTATTTTT TAACTATGAA GGTCTTTTAT TTTCATAGAT AT - #CTATTGCG24480- GTAAAAATTT AAAGGTAATA AACTATGATA AATTGAGCTA AAGATGTGGC TC - #AGTGGTTA24540- GATGTTCATA TTGCTCTTAC ATGAGAGGAG AGTTCAATTC CGATCACCCA CA - #TTAGGTGG24600- CTCACACCTA ACCATAACCC CAGCTCCAGG GGTGTCTGAA AGCTCTGGCC TT - #TGAGGAGG24660- ACTTCACACA CACACACACA CACACACACA CACACACACA CACACACAAA GT - #AATAAATA24720- AAAATGATCC CTAAGTACAT AAATCATAAT TGAAGTAACA TTCAATGTTG TT - #ATGGAGGA24780- TCAGCTTATT GGGAGGTTAT GTAACTATAA TATTTACATT TTTAAAGAAT AG - #AAAAAATC24840- TATTTCTATA ACAAAGCTAA CTGAAACAGT AGAATATAAA AGGCAAAAAC AT - #TGATATTA24900- ATATTTTGTG AAATTTAAAT AAAAACCAGC AATCAACTGA AACTGAAAAT AC - #CATAAATG24960- ACAATGCTCT TTCTTAGGTA TTTCTTAGTA GTTTTGTTTC GCATTCTTAA TT - #TACATTGT25020- TGTATAAAGA AGAATAAACC GAGTTACTGA ACAGAGCAGC AAAGCTTGTA AT - #CTAAAATT25080- TAAAGATGTT TATGTTTTAG TTTTCGAATT AACAATTTAT AATTCTGAAG AT - #AATTTTTT25140- CTTAATTTGT TTATTATCTA AATGCATTTT ATACATCAAC CATATTAATA AT - #ATTGAACA25200- TTTTGAGACT CAAATAATAC ATAAAAAATT TGTTCAACTT TTATTTTCAT AT - #CCTGAAAG25260- TATCATTAAT GAATATTTAA TACTATCCAT AACTGAGGAT CCTATATCTA AT - #GTTAAATA25320- CTAAATTGTT TCAAAACATA CAGAATATGC TTAGGGAGTT AAGCATAGTA AA - #AGAGCATA25380- GAATATTAAA AATGAATCAT TAAAAAATAC ATTAAAAAGC CCTTATATGA TA - #CCACATGA25440- CATAGTGAGA GAGTATTTAA AACGCATTAT ATATCTGTGT GCATTGTCTA AC - #AATCAGTT25500- TACTTAAAAA AGATTATCAG TGTTTCTAGG AGAGAAATTA TTTTATCAGT AA - #GTATATTT25560- TAAAAATTAC AAAATAGCAA AAACTCTTTG AAGTTAACAG TAAGAAAATG CT - #AATTTCAA25620- GCACAGTGAG AAAAATTATC AATAATATTT CCATGATGTT TGTAGAACAT GA - #TTTTAATA25680- TTTTCAAATG TTGATATTCA ATAAACAGAA AAGTTATTTG AAGATATATT TC - #ATTGTTAT25740- GTCTCCCTTT TAATTTTTGA TTTTATTAAT TTGGATACTG TCTCTATGCC CT - #CTGGTTAC25800- TCTGGCTTAG GGTTTATCTA TCTTGTTGAT TTTTTTTTCA AAGAACCAGC TC - #CTAGTTTT25860- GTTGATTCTT TGTATAGTTC TTTTTGCTTC TATTTGGTTG ATTTCAGCCC TG - #AGTTTGAT25920- TATTTCCTGC AGTCTACTCC TCTTGAGTGT TTTTGCTTCT TTTAGTTCTA GA - #GTTTTCAG25980- GTGAGCTGTC AAGCTGCTAG TGTAAGCTCT CTTCAGTTTC TTTTTGGAAG CA - #CTTAGAGC26040- TATGAGTTTT CCTCCTACCA CTGCTTTCAC TGTGTCCCGG AAGTTTTGGT AT - #GATGTGTC26100- TTCATTTTCA TTTCTGCCTT GACCAAGTTA TCATTGAGTA GAGCGCTGTT CA - #GCTTCCAT26160- ATGTATGTGT GCTTTCCGTT GTTTGTGTTG GTATTTAAGA CCAACCTTAG TC - #CGTGGTGG26220- TCTGATGATA GGGTGCATGG GATGATTTCC ATCATCTTGA ATCTGTAGAA GT - #CTGTTTTG26280- TGACCAGCTA TATGGTCAGT TTTGGAGAAG GTTCCATGAG GTGCTGAGAA GA - #AGGTATAT26340- TTTTTGCTTT TGGATGACAT GTTCTATAAA TATCTGTTAG ATCCATTTGG TT - #CATAACAT26400- CTGTTAGTTT CACTGTGTCT CTGCTTAGTT TCTGTTTCCG TGATCCTGTC CA - #TTGCTGAG26460- AGTGGGGTGC TGAAATCTCC CACTATTATT GTATCAGGTA TGATGTGTGC TT - #TGAGATTT26520- AGTAAAGTTT TTTTATGAAT GTGGGTGCCC TTGCATTTGG AGCATACATG TT - #CAGAATTG26580- AGAGTTCATC TTGGCAGATG TTTCCTTTGA CCAATATGAA GTGTCCTTCC TT - #ATCTTTTT26640- TTTGATAACT TGGTTGAGAG TTGAATTTAT TCCATATTAG AATGGCTACT CC - #AGCTTGTT26700- TCTTGGGAAA CAACCATTTG CTTGGAAAAT TGTTTTCCAA CCTTGAACTC TG - #AGGTAGTG26760- TCTGCCTTTG TCACTGAGGT GCATTTCCTG TATGCAGCAA AATGCTGGGT CC - #TGTTTACA26820- CACCCAGTCT GTTAGTCTAT GTCTTTTTTT GAGGAATTGA GTCCATTGAT GT - #TAAGAGAT26880- ATTAAGGAAA AGTGATTGTT ACTTCCTGTT ATTTTTGTTG TTGTTAGAGG TG - #GAATTATG26940- TTTGTGTGGC TATCTTCTTT TGGGTTTGTT GAAAGATTGC TTTCTTGCTT TT - #TCTAGGGT27000- GTAGTTTCCC TCCTTGTGTT GGTGTTTTCC ATCTATTATC CTTTTTAGAG CT - #GGAAAGAT27060- ATTGTGTAAA TTTGGTTTTG TCATGAAATA CCTAGCAGCT TGACAGCACA CC - #TGAACACT27120- CTAGAACTAA AAGAAGCAAA TACACCCAAG AGGAGTAGAC TGAGATTGGG AG - #TTTTGCCT27180- GGGCTGGCAT TTGTGTTCTC TTAGGGTCTG TATGACATCT GCCTAGGATC TT - #TTAGCTTT27240- CATAGTTTCT GGTGAGAAGT CTGGTGTAAT TCTGATAGGC CTGCCTTTAT AT - #GTTACTTG27300- ACCTTTTCCA TTGCTGCTTT TAATATTCTT TCTTTGTTTA GTGCATTTGG TG - #TTTTGATT27360- ATTATGTGAC AGGAGGAATT TCTTTTCTGG TCCAGTCTAT TTGGAGTTCT GG - #AGGCTTCT27420- TGCATGTTCA TGGGCATCGC TTTTTTTAGG TTAGGGAAGT TTTCTTCTAT AA - #TTTTGTTG27480- AAGATATTTA CTGGCCCTTT GAGTTGGGAA TCTTCACTCT CTTCTATACA TA - #TTATCCTT27540- AGGTTTGGTC TTCTCATTGT GTCCTGGATT TCCTGGATGT TTTGGGTTAG GA - #GCTTTTTG27600- CATTTTGTAT TTTCTTTGAC TGTTGTGTCA ATATTTTCTA TGGTATCTTC TG - #CACCTGAG27660- ATTCTCTCTT CTATCTCTTG TATTCTGTTT GGTGATGCTT GCATCTCTGA CT - #CCTGATCT27720- CTTTCCTAGA TTTTCTAACT CCAGGGTTGT CTCCCTTTGT GATTTCTTTA TT - #GTTTCTAG27780- TTCCATTTTT AGACTCTGGA TGGTTTTGTT CATTTCCTTT GCCTGTTTTA AA - #GTGTTTTC27840- TGGTAATTCT GTAAGGAATT TTTGTGTTTC CTCTTTAAGG GCTTCTAGCT GT - #TTACCTGT27900- GTTCTCCTGT ATTTCTTTAA GGGAATTATT TGTGTCCTTC CTAACGTCCT CT - #ATCATCAT27960- CATGAGAAGT GATTTTCGAT CTGAATCTTG CTTTTCCAGT GTGTTGGGGT AT - #CCAGGACT28020- TGCTATGGTG GGAGAATTGG GTTCTGATGA TGCCAAGTAA CTTTTGTTTC TA - #TTGTTTAT28080- GTTCTTCAGC TTGCCTCCCG CTATCTGATT ATCTCTAGTG CTACTTGCCC TC - #GCTCTGTC28140- TGACTGGAGC CTGTCCTTCC CGTGATCCTG GTTGTGTCAG AACTCCTCAG AG - #TTCAGCTG28200- TCTCTGGGAT CCTGTGATTC TGGAATCCTG TGATCCTGAG ATCCTGGGTG TG - #TCAGAGCT28260- CCTGGGACTC AAGCTGCCTC TAGGAACCTG AGATCCTGGT GTGACCAAGC TC - #CTGGGATC28320- CTGGGATCCT GGGATCCTGT GGACCTGGGT GTGTTAGAGC TCCTGGGAGT AG - #AGCTTCCT28380- TTGGGTGTTG TGCTACTGGC TGTGGAGTTT GCTCTCAAGA TCTGCTCTGG GC - #AACGGCTC28440- AGAGTGGATG GGACCTGTGC CGCTGGTCAG GTGGAGTTCC TGGGTGCCTG GG - #TTCCACTG28500- CTCCCAGTTA CTCCCGGTGT TGGGGCAGAT GTTGTGCCCT CCTCACCTCT GA - #TCCTATGA28560- TCCTGGGAAT GTTTAGGGCA CTTGGGAGTG AGCTTCCTCT GGGTGTTGTG GG - #ACTGGCTG28620- CGGAGTTAAT GCCCAAGGTC TCTGCTCAGG GCACTGGCCC TGACTGGAAG GA - #ACCTGTGC28680- CAGTGGTGGG GCGGATTTCC TGGGCACCAG CCCAGACTGG AACAGAACAC TT - #TTATTTTT28740- ATTCATTTAT ATTGTTCAAA ATAATGAGTT TCGTTTCATT TCCATAACAT AT - #TTAATGTA28800- CTTTGGTCAT ACTTATTCCC TAAGAGATCG TATTTTGTTT TAATTTTAAG TC - #AAATTATA28860- TACATATTTC TTTGTAAATT AGCAAACTGC ATACACATTT ATACTTAGAT AC - #AAGATAAA28920- TGCTTAAATT ATTTTATGAG GTATTTACCG TTATGTTTGA ATAATTTTAT TA - #GGATGTTG28980- TTTCCTCTAT CTGTAACAGG TAATAAAATA AAAAATTGAA TTCTTAGCAA TA - #GAATAGCT29040- AATGATTTAG AAATAAATTT TAAGACAGCC TTTTTCTTTT CTGATAATGA AA - #TGGTTGAG29100- TACCCTGGTT GAGTGTGTCC CCATTGTAAT AGTTATAAAA CATGAGCCAT CT - #ACATGGAA29160- GATACCTTGC TCACCTACAT GTGAATTTCT GAACGAAATA TTCATGGTCT TC - #CTGCCTCC29220- TATTGTGCCT CTTGATTTTG ATGCTCACCC TATGGAGAAA TGCTAGAAAA TA - #GCCTATGA29280- GTCAGTTGCT TAAAGAATCG GGTAGTCATA CATGTCTCAC TTTCTACATA TT - #GATTACAT29340- CCAGAATGGC ACTGAGAACT CAGTAAGACA GGAGAGAGGT TGTAATGGCT GT - #TGGGAGAC29400- TTGCTTCCAC AGCTGGAAAG CCACATGCCA ATATAATTTT GAAGAACGCT TC - #TCACAAAA29460- TAAAAGATAA ATTGTTTTAT GTAGCTAGGC TATTAATTTA TAACCCTGCC AG - #GGCTTATG29520- TATTGCAAGT TACAGATTAT TAAAAAAGAA CGAGATGTAT TAATCCCCAC TT - #CTATTAGC29580- ACTAAAGTAT AAATGGCTAA TAAGTAGTTT TAATTTAGTG GGACAAGATA AA - #TTGCATTG29640- AAATCTCATG ATTTAGTGTT TGATTTATTA AGTAGGAGAT AACTTTTCTC GT - #TTAAAAAC29700- ATTTTTTTTT CTCTTTACGT AGGGCTCGTA GCTTGGTGGT AGAGCACCCA CT - #AAGCATGC29760- CCAAGGTCCT GGGTACCATC CCCAACATGA CAAAAAGAAA TAAATATTCT AA - #TAAACCAA29820- AACGTTAGCA TGTGTGTCTT GGCCATGGTT CCTGTATGGT TGTGACTGTG GA - #TGTGTCAG29880- AAGACAGTGA GAAGTCAATG CGCCTTTTAA ACGTCCGTTT GTATTGGATT TC - #CCCCCAGG29940- TTCCAGTCAT TGCACTCTCC GCTACTGCAA GCTCTTCCAT CCGGGAAGAC AT - #TATAAGCT30000- GCTTAAACCT GAAAGACCCT CAGATCACCT GCACTGGATT TGATCGGCCA AA - #TCTGTACT30060- TAGAAGTTGG ACGGAAAACA GGGAACATCC TTCAGGATCT AAAGCCGTTT CT - #CGTCCGAA30120- AGGCAAGGTA AAGATAGGAC GCTAGACGAA AGGATCTTTT AAAGAAGTTA TT - #TTATTTTT30180- TTCTATTTCT TTTTTTGATA TATATTTAAT GTCTCAAATT TTATGTAGCC TT - #GGCTCAAA30240- TGAGTGTAAT ACTACATAAT CAATTCAGTG ACCAATATGA AACCACTAAA AG - #AAATATTT30300- CCATTCATTC TTTTAGAATT TCATATAGTA TACTTTGATC ATATCCACCC CT - #TATTACTT30360- TCCCAACTTC TCAACGGAAA CTAGCTCTCC CTCTCCCAGA AGCTATCAGC TG - #TCTACAGT30420- CTACTGCTTG GTTAGGGGTA GGGGCTTGGT CTAGTGTAGA CAAGGGTTCA TG - #AGCGCAGT30480- GGTCCTGCCA TGACCAGGAC ACATGGCTTT GCTTCAGTTT TCTCTGACCA TT - #GGCCTTTG30540- TGTTCTATTT GTCCACTCTC CCATGGTGTT CAAAGCATTT GTATTTTGCA AG - #GGCAGAGG30600- AGATGTGGCC AGGAACTAAT TTGTCTAATA TTATTTTTCT TTTATATTGT TA - #TTCAAATA30660- AGAGATATTC TTTTAATAAT TTACAACTAA ATGAACAAAT ATGACATGAG CA - #TTTCTTAT30720- GAGTTCTGTC TGCTTTCATA TTTAGATGAT CTACCTCTGC TGGAGGGGCT TT - #TTAATAGT30780- CAGTATAGAG TCTGTCCATG TTCCAAGGAC TGTCCTAGAT GCTTTATACA AG - #TGATCTTG30840- TTAAATCCTC TAGCATAAGG AAGTTCCTGT GTACATCTAT ATTTTACTGA TG - #AAACTGTC30900- CATTACACTT CTAAGATTTG TATTTTAAAA TATACTTTAT GCTTTATTTT GT - #ATGCGAAG30960- AACCTTTGTA ATGCCATTAT TCTCTGTCCT GCCTGCTGAG TTAAAAGTTG AT - #ATTTTCCT31020- TATATTAAGT ATTCTGAATA ATGAAAAATA ATTTTCTCCT ACCAATACCA AT - #GCAAACCA31080- AGTCCAAGCA AGAAAGAGCT GAGAGCATTG TTAGTGTTTT CCTCGTCCAG AA - #AGGATGTA31140- AATGGGAAGA GAGATCCTAG GTTAAGGAAG TGATAGTGTT TGTTGTAGAT AC - #TAGGAAGT31200- AGTTTAAGTA CCACCTGAGA AGTGCTCGCT ATTCCGAGTA GAATAGGAAG AT - #GGGGAATG31260- TATTGATAGG GTTTTGCTGC TCAAGCTGCC TCCTTGAACC TGCTGTTCCA TG - #GTCCTTTC31320- CAGTAAAGGA AAAGTTCTCT TGTCAAAGGC TTCTTCTAAA CTGGATGTTT CT - #ACACTCAT31380- GTCATTACTA ACCCCTGATC TTTTAGTTCT TGTCAATGCA CATTATTTTT AA - #TATCTATG31440- GCTAATTTTT ATAGTGACCC TCTTCTTTCA TATGTATATG TGTGTGTGTG TG - #TGAGTGTG31500- TGTGTGTGTA TGTATATATG TGTGAGTGTG TGTGTATGTA TGTATATGTG TG - #TGTGTACG31560- TGAGTGTGTG TGTGAGTGTG TATCTGTGTG TGTGTGTGTG TATGTGTGTA CA - #CACACGTT31620- AAAGTGCCTT CCCCCATCTT TTCTTGTGAT GTTTTGTTTT CCCATTTTTG GC - #ATCATTTG31680- CCTTACAATA TCTTATGCAA ATGCCTTCTT CCCAATTTAT ATTGATATTC TG - #GTAACGAT31740- GATTAATTTA ATTTTTAGCC CAGATTTTTC TGATCACTCA TAACACATCT AT - #ATCCTCGG31800- TGCTACTTGA TATATTCCAC AGATAACTTT CAGGTTTATC ATCTGCAGAC AC - #GTCCTTAA31860- ACCTTGGAGT AAAATTTTAT TTTTAAACCT TGTATAATAT TTTATGCAAC AG - #TGAAATTA31920- TTCTCTCACC TCTTAAATAA GAATAGATTA ATCTATTGTG CTGCCTTTCT AG - #ACTCATTT31980- TTATCCATAC CTTGTAAGTT TTAGAATCAT TTTTTTCCTA AAACAAAGTG AT - #TCCTGGTT32040- TTAACTTTAA TTTGGGCCAA TGTTGAGTGC CAGAGTTTTG CTTTCACACA AT - #ACGTTTCT32100- ACGTTTGTCT TTCCAGAATG TTCTGGAGTT TCAGGGAGTT GAAGTGTTTT TC - #AGTCTGCT32160- GACTTCTTTA AGACTTTTGC TTAGTGAAAG CAAAGATTAT GAAAGATGAA TC - #CCAAACTG32220- CGATGAAACA TACATGTAAC AGGCGTGTTT GCTTTCTCTG TCTCCCTACC TC - #TTCCCCAC32280- CCTTCCACAG TTCTGCCTGG GAATTTGAAG GTCCAACCAT CATCTATTGT CC - #TTCGAGAA32340- AAATGACAGA ACAAGTTACT GCTGAACTTG GGAAACTGAA CTTAGCCTGC AG - #AACATACC32400- ACGCTGGCAT GAAAATTAGC GAAAGGAAGG ACGTTCATCA TAGGTTCCTG AG - #AGATGAAA32460- TTCAGGTGTG CAGAGCAACC ATCTTTCTCT GAATTCTTCA CAGGAAGTAT AC - #GTATCTGT32520- CAAACATTTA TGTCACCAAT TTTTTTTTTA AAATTGTTGT ATTAAGCACA GT - #TTCACCAC32580- TCTGATAAAG GTAATGACTG TATAGTGAAA TTGGATTAAA TAAACCCTAC AG - #CTTAGTGT32640- AAATAGCAAA GACTGTCATC TGTTACTGGG CTACACAGAG AATCAACACC AG - #TTCTGTCA32700- GAGTAGGTTA TGTAATGAGA GTGGTCATCA GGAAGCTGAA ATCTGAGAAG AG - #TCTTAAGT32760- ATGTCAAGTT TACCAGGTCA GTAGGTAACG AGGGCTGTAG AGTCCCAGGA AG - #CAGCAGCA32820- GGTGCAGAGA CACACGTTGA GTGCATCCTG GGCTCAGAGA GGAAGAGCCT GA - #GGTGATCG32880- GAGGAGAAGA TGAGCGGTAG GAATGGCACA GTCAGGGGAC ACAATGAGAA GG - #TTAGACAC32940- TCTCAGGAAG GCTGCGTTGG ATGGTTGGCC AGCTTAAAGA TGAGAAGGAT CC - #CTGGTTAA33000- TGGTGCTCGC CCCCTACCAG AAAGCATCTA TTGTCACTCT TCCTGTAGGA AC - #GGCACTAA33060- TGCTTATGAG AGGTTGTTGT GCACACTTAT TAATACTTTT ATTACTTTAG CG - #ACTGGGTC33120- CTTTGGATGC ATCTGGCATA CTGCCTGTCT TAGGTACTTT TCTGTTCTAC TA - #CTGACTGA33180- GGCAACTTAC AGAAGAAATA GTTTATTGGG GCCTACAGTT TCAGAGAGGG GG - #TCTGTGGT33240- CACTGTGGAG AGTGTGCAGC AAGCAGATAG GCATGGTGCT GGCGCAGCGG GT - #AGGCAAGG33300- TGCTGGAGCA GCGGGTAGGC AAGGTGCTGG AGCAGCGGGT AGGCAAGGTG CT - #GGAGCAGC33360- GGGTAGGCGT GGTGCTGGAG CAGCGGGTAG GCGTGGTGCT GGAGCAGCGG GT - #AGGCGTGG33420- TGCTGGAGCA GGAGCTGGCA GCTTGAGCAC CAAGAGAGAG AGCTAGCTGG AA - #TGGCACGG33480- ACCTTTGAAA TTTCAAGGCC AGCCTTTAAA GCCTGCTCTT CCCCACAAGG AC - #ACACGTCC33540- TAACTCTTCC CAAACAGTTC TCTCACCTAT GGATCAGCGT CCAAACATAT GA - #ACCTATCA33600- GGGCCATTCT TGTTCAAACC ACCACACTGC CAATGTATAA CTTGATTGAA GC - #ATTAAATT33660- TATATATATT AGTTTTTTGA GACAGGGTTT CTCTGTATAG CCCTAGCTGT TC - #TGTGGAAG33720- TATTAATATT TTAAAAGAAG GCTTAAAAAT CTTTAGTGAT CTTTCATTAC AG - #TTAATTTT33780- GAAGGTTATC TATCTACCTA CCTACCTACC TACCTACCTA CCTACCTACC TA - #CCTACTTA33840- TCTACCTACC TACCTACCTA CCTACTTACC TACCTATCTA TATTTTGCAT GC - #CCTGCTGA33900- ATTTTCTCTT TCTAGTACAG GAAGTCATCA ATTCGAATCC ATATTATAAA AA - #TTAAAGTT33960- TAGATGAATA GTTGCATTCT AGGTAGCCCG AGGTAGTGTT TTGTCTAACA GC - #TGAACCGA34020- TAGACTCCTT CCTGGTCACA ATTCAGAAGC CTGGCATATG CTTCGAACCT TC - #CCCTTTCT34080- TAGCACAGTG AAAGGCATGT TGTCATCAGT GTAGACTTAT CTGGACTCTT AG - #AGCTGATT34140- ACTTTTTGTT GGGTGTTCGT TGAGTGCCGA CTGAATTCAT AAATGTAATG AC - #TTCTAGAT34200- AGCTACTTCC TGACCATTTT ACAGTGGATT TTTACTGTAT GGCAGGCACA GA - #GGCTGACC34260- TCTGTAGCTC TTCATATGTT AGACTGATGC ATAAAGCCAT TTTCTGTTTT AC - #AATTTTAG34320- AAACAAAGGG AATTTCCTTT ATGTCATATA TACTCAAATC CCATGCACAT TA - #GCTTTCCA34380- TGATTTGTTT ATAACTGTCT GTTCTCAAAT TTTATCCCAA CCCTTAGTTT CG - #TCCTTCCT34440- ACATTTGCCA TTTTAAGGTG GCTTTTTAAA AAATGAAATG ATGAATAACT TA - #TTTGGTAG34500- AATAGTTTTC ATTTATATCT AAAAGTTTAT AGGGACAGTG TGAAAATCTG GT - #TAATAGAA34560- TAGTTAACAT CAAATGAAAG AATAATCCGG TGAAGCTTAG AATTCCATTG GT - #TATTGACT34620- GCTAGCTGGA CTGAGCTGTT AGAATTCCAT TGGTTATTGA CTGCTCGCTG GA - #CTGAGCTG34680- TTAGAATTCC ATTGGTTATT GATTGCTCGC TGGACTGAGC TGTTAGAATT CC - #ATTGGTTA34740- TTGACTGCTA GCTGGACTGA GCTGTTAGAA TTCCATTGGT TATTGACTGC TA - #GCTGGACT34800- GAGCTGTTAG AATTCCATTG GTTATTGACT GCTCGCTGGA CTGAGCTGGC TT - #CTTGCACC34860- AAAGCTTTTG CTTCCCACGT CTGTGCCGTT ATCCCCGCTC CCTCACCCCT CA - #CCCATCCT34920- TTGCGTGTTT CCTATGCTCT TCCTTTCTCC TTTCTGTCAA TCTCCTGGGC CA - #TCCTAGAA34980- CATACCCTAT GAGCTTATTT TACTGTTGTC TCTTCAATGA GGCGTCTTCT CC - #CCTCCCCT35040- CTCCTAAGCC TTCGATCTGA CTTTGGAGGT GTTTATTGCT CTACCCTGAC AC - #AATTTACT35100- TATACTGCTA TCTTAATTTA TTGTCAGTTT TTATGATTCT CTATTGATTC CC - #CACTAAAA35160- ATGCCGGAAA TTCACCAGCC TTTCCTCTGT GTTCCTGCAG CCCTGGACCC CT - #TTCCCTTT35220- GCCTGTTGGT TTATATCTTA ATTCTGCTTA AATGTCATAT GGTTATCAAC TT - #AAGCATCT35280- TACCTTTAAT TTTTATAATA TATGGTTATA GTTCTCACAT ATATTTTTGT AT - #TCTTGTTA35340- TTAAAGGATT TTTTTTCTGA GTATTTGTCC CTAATTCTCC TGTGAGTTTT TT - #CCAACCAT35400- ATGAACTTTA TTTTGTTAGG TTCATTCACA TTAGGTCATT TGACAGTTTT AT - #CCTCTTGG35460- TATTATACCC GTCTTTTTTG TTTTTGTTTC TGTTTTTGTT TTGTTTTGTT TT - #GTTGTTTT35520- CTATTGTACC CATCTTAATG ATGCTTCATT AGCTGTATTT CTCTTTGCAG TA - #GTGAATGG35580- TATTATACTT AGATTCTGTC ATCAGGAGAG GACATTCGAA ACTTGATAAT AA - #TACAATAG35640- TTTTATTCAC TACAGTAACT GTTTCTCATA GCTTCGGGTC TCCAGAGAAA CT - #CCTTTATT35700- TGCTCCTTTT TATAGAGATG AAGAGAAGTC ACATTTTTTT TTTTAAAGAC AG - #GGTTTCTC35760- TGTATAGCCT TAGCTGTCCT GGAACTCACT CTGTAGATCA GGCTGGCCTC AA - #ACTCAGAA35820- ATCCGCCTGT CTCTGCCTCC CAAGTGCTGT GATTAAAGGC GTGCACCACC AC - #TGCCCGGC35880- CAGAAATCAC ATTTTTATAG CCACTATTTA TCCAAATCTG TATTTGGATA GA - #TTATCTTT35940- TAGTCTGTAA GTAAAGTTAT ATTTAATTTA GTTTTACACT GGCGGGCAAG CT - #GCTGTTTT36000- ATTTTGTAAG TTTTAGTTAA GTTGAAATGT GATTCTTACT CTGCGTTGTT GT - #TCATTCTC36060- AGTGTGTTGT AGCTACTGTA GCTTTTGGAA TGGGCATTAA TAAAGCTGAC AT - #TCGCAAAG36120- TTATTCATTA TGGTGCGCCT AAGGAAATGG AATCCTATTA CCAGGAAATT GG - #TAGAGCTG36180- GCCGGGATGG ACTTCAGAGT TCCTGTCACT TGCTCTGGGC TCCAGCAGAC TT - #TAACACAT36240- CCAGGTATAA ATGCTTATTG TTTTCACCTT ACAAATTCCT TTTTCCTTTC CA - #AGAAAGTA36300- TTTGAGGGAG TATCCAAAAT ATCAAGTGAC CCCTGAGTAT ATTTAAAGGG GT - #CGCCACCG36360- GAAAGTGAGC AAAATGAACA GAATATCCCT GAAGAGTGTT TTTGGTAAGT CT - #TCCCACAT36420- AGCAGGTGAT CCAGTTGGAG TTAACAAGAT CGGGACTGCA CTTGGACGTA TA - #ACATAGGT36480- CTTATGGCAT CCTGTCCTAT TGTGCAGCAG TAAGCAGTTC CCACATTTTA AA - #TCCTCCAG36540- TCATATGGCT CTAGGTTTAA GTAAGTACCA TGTGTCCAGT GCTATAATGG TG - #GTTATTCT36600- AAAAGATGTA TCCAATTCTT GTTTAACTCT CTTTACTATT GTTTCTGTGA TT - #AGTTCCGT36660- AAGTGCATGC CACTGCTCAT AGACTGAAAA CTCACCTGGT TGATAGTGCC TA - #AATAATGT36720- AACAGCGTAG TGTTAGAGTG CTGTCATAAA ATAGTATATG TTCGTGGTTT AA - #ATTCAAGG36780- AAAGGGAAAC TGCCTACTTA AATGCTAACT AAATTGTAAC TTACATCCTG CC - #AGATTATA36840- TTAGAAGCAA CAGCTTCAAT TTCCAAAATC ATAGGGACAT TATTTACCAG TT - #ATCTATCT36900- ATAGGGAACC AGGAAAAGAA GCCAGTGCAG CCCAGCCAGT GAACGTGCCA AC - #ATAAAGGA36960- CCTTTCAGTG CTCCTCCAGG CTGATGAGTA AGCTAGACAC TGGTAGCTAA AA - #GAGTAGGA37020- TTAGATAAGT AAAAAGGGTT GTTACAAAAT CTAAGATCTT GCTAGGAATA GT - #CAGTATAT37080- TTTACTTTGT AATAAGTAGA GCTGAACTCT GATCCCCTGA AAGCAAGCAT TC - #TTAGCCAC37140- TGAGCCATCT CTCCAGACCA GGCGCCAGAG TCTTTACCCA GCCTTTTAAA AA - #CCAATTTA37200- AAGTAAGTTG GATAGAACAC ATCTCTGCAA GCTACTATTA AATTTGGAAT AT - #ATCAAATA37260- TCACTTGGTT AAGACCAGAT CTTATTTTAT TTGTGTATTA TGCTAACATG CT - #GGAAACAT37320- TATAGGCCTG AGTTGTATAA TGCAATCTCA CCCGTGGATA TAGTGTTGAT TT - #ATGTGGGT37380- TTTGAAAGAT ATGCTGAGTG GTTTATCTCA TTAAGATTGA TCAGGAAATA AT - #AGTTGTGC37440- CAGAATACCC GTGCAATTGT TACTTAGTAT CCATGGTGAC TGGTTCTGAG TT - #CCTTAAGA37500- TAGAAATAAA TAAATAATCT CCCTATACAT GAGGCTCTTA TACAACATAG TA - #TTTGTATA37560- CAGGCTGTGT ACTCTTCTAC ATACTATCTT CCTAGCTCAC ATATAACATC TA - #TTATAAAG37620- TAATTGATGT GTAAGCATTT AGTTTTACAC TGTAATCTTT AGAGAATAAC AA - #TAAGAAGA37680- ATGTCTCAAT GTGTTTAGTA CAGATGCAAC TACTGTAAGC CTAATTGGGG TT - #TAACTTGG37740- GGTTGACCGA CTCTCAAGTG CTGAACTAGT GGGTGCAGAG CTGAACCACT CG - #CTCTTTTA37800- GTACAGATAG GCTACTCTGT GTATCAGAGA CAAAGGAGAA AAACTGTAAA AG - #GATAAACA37860- GGAGAGAGCC AAGGATTAAG GGTGAGTTTG TACCATCGAG ATCTTGAAGC AG - #AAGAAAGC37920- AGTGAGATTC TGGGTCTCAG CTCTAAGGGT CATTGTAACT TATAAAGTTG TA - #GTCTCGCG37980- TATGCTAAAA TTCTGTGACA AGGGAAGAGT CTTGTTTGAG GGATCATGCC GT - #GATTTTAA38040- CTAACTAATG TTTATTTGTT AGTTTTGTGA TGCTGGGTAT CAAATCTGGG CC - #ACCCTCAT38100- GCTAGACAGC CTATGTAAGC CACATCCTCA GAGACGATTA TGTAGTTTTA TG - #TTCCCTTA38160- TTGTGTGATT TTTGTGTTTC TTACTGCCGA GCCGTAACAA GGCAGTGTCC CA - #GTGATTAT38220- GTTTATTATA TTTGTAGTCA TACCCAGTAG TTACTGCCAT CTTTTGTTTC AA - #AGTGAAGA38280- ACTTAGAGAA TAATCTCTAA TAAATCTTTG AATTCTCTTA AAGTTAATGA AT - #TGTTAGAA38340- TTTATGGTTT TTTTGGTGAA ATAAGTTGTA TTGCGCATTT AATAGTAGCA AA - #AGAAGAAT38400- AAACTAATAA ATATTTAATT GAGTTTCTTT TTCTCAAATG AACATGTAAA TG - #AGCATGGA38460- TGAAATCAAA TAAATATATT TCATCTCAAT CCAATATACT AAGATATAGT TC - #TGAGTATT38520- GTTGACTTTA TCTCTGAAGG ACAAGGGAAC TAAATGAAAC TGATTTTTTT AC - #AAATCTAT38580- GATCCATTAA GTATGGGCTT GGATAATAGC TCAGGTTAGT ATTTTTAGTT CA - #GGGTATTT38640- GGAGGAGAAA ATTCATGTGA AGGGTGTTAT CCATTGAGAA CATATCTTTG AA - #TAATGGAT38700- CATTTGTACA TTCAAATTTT CTAGAATAGA GATTGTATAC AGATATTTTG AT - #TAATCAGA38760- AGGCTGGATG TTACAAACAT TAGTGAGCAA AGTCCCTAAT GATGAAGTTC AG - #TATTATCA38820- TTTAGTTCTT GTATATTAAA TCAGAATGTT ATATTGCAAT ATCTAAAATT CA - #TTTCATGC38880- AGGTTTTTTT TTATTATTAT TCTTGGAAAG ATGTGGAACA CTGCCTGGAA GA - #TTTCATGG38940- CCTAATGCAA TAGCACTGAT GTTTAAAGAT AAAAACAAAC ATACTGGTAC TG - #TTATTTCA39000- CAATTATAAA CAACTTCATT ATTGTGACCA AAAAAATTCA TTACAACTCA CC - #AAGGAAAA39060- CACTCAATTC TAATACTTTA CTCCTGTCCT CAAGGGCTTC GCAATACAGA GG - #GACAGCTT39120- TGGAGCTGAG CTGTCCTCTG AAAAGCCAGT AGGAGTAGAT GAAGGTTCAG AC - #TGGAGTGA39180- CGGGGATGGA GACTAGAGCG ATGGGGATGA AGGGTCATAC AGACTAATGA GC - #CTCTTTCA39240- GTTTTCCTTA CATAGATATT TTAACTTTCT CAGAGAACAT TTATTAAAAT AA - #AAGATGAA39300- TTTCCAGTGA AAGGTCCAGG ATCCATGTGC TAGAAGGCTT ACTAGAAACT GT - #GATGAATG39360- AGGTCTGTAA ATCAAAAGGA AACCTTGAAA GTTATCAGTG GAACTCTCTT GT - #CCAGGGCA39420- TGATTAGGAA GAATGCAGGC ATTTGGGGGA GCAAAATAAT AAAATTAACA GT - #ATAATTTT39480- AGATATTCTT GTGATTTTTC CATTGGCAGG AATCACCTTA TTGAGATTCA TG - #ATGAAAAG39540- TTCCGGTTAT ATAAATTAAA GATGATGGTA AAGATGGAAA AATACCTTCA CT - #CCAGTCAG39600- TGTAGGCGAC GGTATGTATT ACCTGCTTTT TCCAATTGGA AGCATAGGTC TT - #TAGCTGGT39660- ACTTTTTTTG TTGTTTGTTT TTTTGAGACA GGGTTTCTCT GTGTAGCCCT GG - #CTGTCCTG39720- GAACTCACTC TGTAGACCAG GCTGGCCTCG AACTCAGAAA TCTGCCTACC TC - #TGCCTCCT39780- GAGTGCTGGG ATTAAAGGCG TGTGCCACCA CTGCCCGGCT AGATGGTACT TT - #TTTTTTTT39840- TAAAGTTAAT TAAAAGTGTT TTTAAAGAAT GTTTGCTGTA TACATGCTGA AC - #TTTAGGGC39900- AGGCTTATTT CTGTTTAAAT AAATTAATAT GAAATAATGC TGAGACAAGT AA - #ATACAGTA39960- GTGGTACTAT CGTGTCATTT TGGGTGGTGG GTGTAGTATG TCTATATTTG TT - #CTTTAATT40020- TAAGATTTTC CCTTCATCAG AATCATCTTG TCCCATTTTG AGGACAAATG TC - #TGCAGAAG40080- GCCTCCTTGG ACATTATGGG AACTGAAAAA TGCTGTGATA ATTGCAGGCC CA - #GGTAAAAA40140- TATCTTCCTG ACGAACCTTC TAGAAACTGT CGATTCTCTT TCTGTTCAAC TC - #CTGCTTCA40200- TTAAATTTTT GTTTAATATA AGTATTTTAG GTTTTGTTTT GTTTTGTTTT GT - #TTTGTTTT40260- TTTCGAGACA GGGTTTCTCT GTATAGCCCT GGCTGTCCTG GAACTCATTT TG - #TAGACCAG40320- GCTGGCCTCG AACTCAGAAA TCCACCTGCC TCTGCCTCCC GAGTGCTGGG AT - #TAAAGACA40380- TGCTATTTTA GTTTTTTTAA ATGACATAGT TACTTTATTT AAAATAAAAC AA - #AGTGAAGA40440- GGTTTACTTT TATACAATAA AGTCTTAAAA CGGTAGGCCT AGTTAGTCAA TA - #GTTGCGTT40500- TCAATATGAT TAGCCTAAAA ATACTCATTA AAGGCATAAT TTATCAAAAT TG - #ATTTGAAA40560- GGCATTCTAC TTGATGTTTA CCATAAGGGC AAGTACAATT ATGTAGATAG TT - #TTAAAAAA40620- TGAAATAGAA AACACTGCAA AAACACTAGC CAAAAGAAAC CGTACGTTAC TG - #TTTTAGTA40680- TTTAGTGGTA TGGACTTTGG AGCAAAGCAT GCTATCAGGG ATGAATCAAG AC - #ACCGACCA40740- GTGTGAAGTA TCAGCGTTCT GCAGAGAAGT GGCACCAAGG AGAGAGCAAG AG - #GGGCAGGA40800- GAGGTGTGGG ATGGAAAGAA CAGGACAGAG GTGACAGGCA TCAGTGAGGT GG - #CAAATCTT40860- AAAACTTGTA GCCAAGTTTT GGTCTGAACC CTGCGTCAGG CACACGCTAA TG - #TTAGTGTT40920- GAAACAAAGT TTATTGCCCA GCAAGCTTGT TTGTATTAAG GCTTTCAACC CA - #AAGAGGGT40980- AGTTATTGGG CATGATTTCC ATTGTTGAAG TCGTCTCATC ATAAGTAATA TT - #CACATCTA41040- CAAAATACAT TTGCTGTGGC ATCTAAATTA TTTTCTGATC AAACAACAGC CC - #CACTTTGA41100- CATGCAAGCT ATACAGCCCA GAAGACATAA TCCCAAGTGG GCACATAAGA AC - #CTGCACAT41160- AAGAACCTGC ACATAAGTAC CACAGAAGCA GAAGGCGGGG GGATCAGAAA CC - #CACGTGTA41220- TTAGGTGACG TCGGCGTCTG CTTACAAGGC AGTGGAATTA ATGGACAAGA AT - #GAGTAGGG41280- CTGCGGGGAG CGATGGGCGT GTCTGCAATG GCAAATTCAG AGGTTCAGAC GG - #GAGATCAA41340- GAGACTGAGA CCAGCCTGTG ATGCAAGTGA TCTCAAAAAG AACCCAGGTC CC - #ATAGTGAG41400- ACTGTGTCTC AAGATCCCGA GAACAAAAGC AAGCGTAAGA CTCAACAGCA AG - #CATGACCC41460- ACCCCAAAGC CCCCAAACAG CCCCCTACCC CCACCCCACT GACTCTATGA GG - #AGATGAAG41520- GAATGAAGAG GGTGTCAGCA AACCAGTTCT AATTAATTTC TTGAAAGCAT TT - #CAGCCACT41580- TGTTCCAATG GCGGCTTATA CACACATGTT TACATAAAGC TAACCTTGAC AA - #ATGAGGAA41640- CTATTCGATT TGGATCAAGT ATGCTTTTTG CTTTAATGGC ATCAATCTAG AA - #AGCAGCAG41700- TGGGAAGAAA AGAGAAATCT CCAAACCCTT AGAAACCGTA CCTCCAAATA AT - #CTTACAGC41760- CACTCAGAAA ATGATCTGAA CCGACGAAGA AGAATATGAA GTACCTGGGA TA - #CAGCTAGA41820- ATGACTCTGC AAAGATAATT TATAGTGTTA ATACAACATG GAAGAGCACA GG - #CTTCAGAC41880- ACATAACTAG CATTCACTTT AAGAAACGGG CAGAGCCGGG CGTGGTGGCA CA - #AAACAAAC41940- AAACAAACAA ACAAACAAAA AACAAAAAAC AAAAACAAAA AAGAAATGGG CA - #AATATGAG42000- GAAGATGAAC AGGAAGGGAG TTAAAAAGAG AAGTGCGTAG ATCAATGCCG TA - #GACGACAA42060- AGCCAATAGA GGGGAGTCGG CGAGCTCACA GGCTTCATAT TTTCCAAGAC TG - #GTGGGGAA42120- AGGGGAGGAC AGTACCAATA TCAAAATGAA GGAATTTCAC TGCAGACCCC AT - #GAATGCTC42180- TGAACAAGCC AGGTTACTGG AAATGCAGTA AAACTGATCT AATAGACCAG TT - #TCTTAGTG42240- GGCTCTAATT GACAGTGCTC AGGCATGGTG AAACTTAGGA AGAATACTCC TC - #TAACTGTT42300- ATAAGGATTG AGTTCTTCCT TAAAAAACCT CTGAAAAGAG AACTCTCTAG CC - #CACCTGGC42360- TTTAGTGACA AATTCCAGCA CCAGAAGAGG ACATCAAACT CATTACAGAT GG - #TTGTGAGT42420- CACCATGTGG TTGCTGGGAT TTGAACTCAG GACCTTCAGA AGAGCTGTCA GT - #GCTGAACC42480- ACTGAGCCAT CTCGCCAGCC CTCCAGCAAA CATTTAAATG AGGAGATATC CC - #TGCTTCTG42540- TAGTGTGGCT GCACATGCAC ACTCTCTGAA AGGCAGAGCT GTAGGGAAGA TC - #AGCCGCTG42600- GCAGAGGTTA AAGGCAGGCA GAATAGATCT GAGAGCAGGG CATTCAGTGG GT - #CTTGAGTG42660- TGACGAAGGT TCGATGGGTC TGCTTATAGG GATATGTACG CTTTATTATA CT - #GTAAATAA42720- AATAAGTATA AGTGGTGCCT CTTTGAGTTA ATCGTGTCTC TAGGTACAGT AG - #CTGTATGC42780- CAGAAGCAGC GCTGTTAGAG ATAGAAATCT AAAGATGTTT GGAAATTAGT GA - #TAACCACA42840- ATAACATATA TTTAAGGTGG TAAGATAATA TGTATAGGTC ATACTTCATG GG - #AACTTGAT42900- AACTTTAAAT TCTCTGAAGA AAGTCACCTG AGCATCCTAC TAAAGAGGTA AA - #TGGGAGAA42960- TAAACCTAAG GCAGGGGATT TCTTCTTTAA ATCAAAACAT AATGGCTTTA AC - #TGGAATAC43020- TGACTGCATT CTTATTGCTA CTTTAAAGAT ATATGTGATG TGGAAAGTAG TT - #GAATTTCG43080- TAATTGAATA TATTAGTTGA TAGTCTCTAA GGACTTCTTT TGTTCTCAAG CT - #AAAAAAAA43140- AATCCTCATT TACACCAATG ATAATTTTAC ATCTACTTGG AGGATGACTA AG - #GAATTTAA43200- CTGCTGAATG TACCAGCAGG ACAAGCTTAT AGGCTCGGTG CTCTGTTGTA AA - #ATTATTAG43260- GGTTCAAGCT AACATGTTAC TGCATAGCAG CTTTTTACTT AAAACCAATT TT - #ACCCTTCC43320- TGGTGTAACG TAGCACAAGC TTCCGTATTT ATATAACTGA TCGTGTGGAG CT - #GCCCTAGC43380- CGGGATGCTT TCCTTGAGCC TGGCATCTTC CCAGCGCCTC CATAACATTT AG - #CTTCTGGG43440- TGCCACAAGA AAGCGCTGTC TGTAGTGCCG TATTTGTTAT TTGTGTCTCA TA - #CGCATAGA43500- TCACACACAT GCCCTTGATT GTAATAAGCT TTATGTGTAG AGTTGGAAGT GT - #CAGACACA43560- TTTGAGAATT TTTTTTTTTA CGTGGTCTAT GTTTGTATCT TTCTATTTCT AA - #GGGAGCAT43620- GCTTTTGTCA GTGTTTTCTT AGGCTGTTCT TACTTTCCTT CAGGCTGAAT CA - #TTGCCTTA43680- CTGCTAACAA CTCAGAGGAC GCATCCCAAG ACTTTGGGCC ACAAGCATTC CA - #GCTACTGT43740- CTGCTGTGGA CATCCTGCAG GAGAAATTTG GAATTGGGAT TCCGATCTTA TT - #TCTCCGAG43800- GATCTGTGAG TGTATCTGTG ATAGCTCCTG GGACTGTTTC TGACAGTGCT TT - #CCACTGTG43860- TGGCTATGGC TTTGGCTTTC TTTAGATGGC TAACTAGCAA CCCGTGTTAG CA - #ACACCTTG43920- AGTTCCATCC TAACCCTGCA TTCATTGTCT TGGACAAATC TTGTCTCACG TC - #AGACGCTG43980- TTTTGCTATG TTGGATGCTG GCGGTCAGCT GTGTGCTGCA GTCTGAAAAT AG - #CCTATTCG44040- TTTACCACAC TGCAATTGCA TTAATCCCTA GACTGGTTTT TCTTAGGATA AT - #TAGGGAAA44100- GTTAACTCCC AGTGTGTCAA GGGACTGGTA GAACAAAGTT GCAGCTTCTG GT - #GCCCAGAT44160- ACGATTATGT TCTTTGCGCA AAACTTGAAT TTCAGGGATT ATGTTGTCAG AG - #GCTGGGTT44220- CAGCAACAGT GTACAGCAAC ATAGTCTCCC TCCGATGGTG TTTTATGTCA GA - #AGTACTTA44280- ACATGCTAAG AAAGGGCTTT TGCTTGTTTT AGTGGTTTAC CAGTGAATAC CT - #GATTTAAC44340- TGGACTCCTT TCTGTTTTGA GTGATTCATG TGGCCTCATT ATGCTGCCAA AT - #GTCACTTA44400- CAAAGTGACA ATAATAAGGT ACAAATACAC ATACAGAGCT GGTTTTCTGT AG - #TCCTTCTG44460- CTTTTATGAT AATTTTATTT CTGAATTAAG AGTCTGTAAA TTTAAGAATT GT - #ATATTAAT44520- ATCACTTAAA TAAACCAAGA GTAGAAGAAG GCAGAGTACT TTGTAGATGG AT - #CTATCTGC44580- TTATTTAAAA CATGCTTTAG AGTAGAGGCT AAATGTTCAT TTTGTATATA GA - #ATTTTAAA44640- ATAATTTAGG TAAGCTTTTG CTGCTTAAAT ACTCAAGAGC TTCATGTAAA TG - #CATTTGCT44700- TGTGCTTGCT TGTGCTTAGA AAGTAATCTA TGGAGTTAGT TATGAAATAT TT - #TTAATGAA44760- ACACATTGAA AACTTGTACT ATCCTTTCAA GTGTCAGTGC TTTCAAGATA AT - #AGAGTTTA44820- AATTTTTGGT TTTAAATGGC AAAAAAGCAT ATAAATGTAA CAATAGAAGT GT - #TACTTAAG44880- CAGTTTTTAT TTCTATCAGC TCTGCAAGAA ATCTCAAATG CCACTGAAAT CC - #GTACATTC44940- GTTTTCTATC TTTGTCACCT TTAAAATCCC TGTAGCCAGT GTGAGTATTT AA - #TTTATGAA45000- AAGTGTCCTT GTTTTGGTTT GGTGCGATCT AGCTGTATCC AATATCAATA AA - #TAAGTTTG45060- TTTCTCGTCA AACTTTCAGT GGTCACAGGA GGGATCAGGT TTCACTTATT AT - #TTGAAAAC45120- CAAGTCAGAC GTCCTCTACC GGCAGTGTCT TCTGGGAGTC CTCAAATTAA GC - #AGTTCATC45180- CTTAGTGAAA CTTTATACTA CCCTTGCTAG CGCAACGTGT AAAGCTTTTA AA - #AAGTATCA45240- CTTAATGAAA ATGTGTAGAT GCTAACAATA GTGAAAATAA GACAGGCTTC CT - #TTCTCTGC45300- TTTCAGTGAC TTTGATATCT ATTGGGATAT CGGTGAAAAA GTATGACTGT AA - #TTCTCTTG45360- AGAACTGAGC AAGTTGTTCC CCTTAACCAA TTTAGGACAA GCTAATACCT TT - #GTAATTTT45420- AATTTGTAAG ATGATATATC AAACTGTCTT GGAGTTATTT TGAAGAGATA AT - #TTTTATAA45480- GCATAAATTC GGTTTTGGTA GTGCTTGATT CTCTCCTACA TGTTTTTTTA AT - #ATTATAAA45540- CACTTAATTT ATCCATAAAT TTGTTAAATT TAGTTTAAAA ATTTGTTTTA AT - #GTGTCTAA45600- TTAGAAAGTA ACCAAGATTG TCTAGAGAAC TTTGTTTTAA CTGACTAAAC AG - #TTCACCAT45660- GTTCAGCAAT CTTTGACATT GCTCAAACGT GTCATAACAT AATCAATAGC CA - #TAATTTAA45720- GGGAAAAAAA CCACATTGAT CATTTGCATA CCAAGATTAG CATCTTCCCA AA - #TGCCTTAT45780- CCAAGTGCTA ATCTTTATCA TGGCCTCAGG AGTAGGTACC ACTTAATATT TT - #AGGATGTG45840- TGTATATGCA CGTGTTCAGG TGCTCTCACA TCTGTGTGTG CATATGAACA CC - #AGAGGTGG45900- ACATTGGATG TCTCCCTCTG GTACCCTCCA TTTCATTCGT ACTCTTTTGA CC - #CAGTTTGT45960- CACCGAACCA GGAGCTCAGT GTCTTGGTTA GACTGGCTTG CCATTAGTCC CT - #GACATTCT46020- CCTGCCTCCG TTTCCTGCCA GCCAGCTGAC ACTGTAGTAA CAGCACCCAG CT - #TGTCTTCT46080- TAAATTATAG TTTACTGGCG TTTCAAGAAC ATCATAACGG ATGCAGTGTA TT - #TTGGTTAT46140- AATCAACCTC AGTATTCTCC CAGCTCTTCC CAGACTGATC CCACTGCCTC TT - #CACCAATC46200- CCAACTTTAT GACCTCCCCC GCCCAACTTC CCCAGCCATG GGTATGGGCA TC - #TGTTAGAA46260- TGTGGTCAAC CTATCAGGAG CTATGCCCGT AAAGAATGAC GATCTCCCTG AA - #GAGCCGTC46320- AGCTGTGAAT AGTTGTTCCC CAGGAGCTCC TGAACCCTTT TCTCCATCCC TT - #GATGAAAA46380- TTTTGCTAAC TTGGTTCTGT GCAGGCAGCC ACAGATGCTG TGGGTTAACG GG - #TGCAGTGG46440- TCTGTCATGC CCAAAAGACA CTGTTTGGTT CTGGTTCTAC ATGACCTCTG GC - #TCTAACAA46500- TCTCCTTTTG GGACGAACCC TGAGCCTTGA GGGAAAGGAG TGTGACCCAG AT - #CTCCCATT46560- TGTAGATGAA CACTCTATAT AGACAATATC CTCTGTGCTG TGCTTTGACC AG - #ATGTGAGA46620- TTCTGCGTTA ACCGCCATCC ACTGCACAAA GAACCTTCTC TGATGAGGCT TG - #AGAGTGGG46680- ACCAATCTAT GGCTATAGGA ACAGGAACTT AGAGACAAGT ATAATTCTAT GT - #CAGTTTAG46740- CAAAATAATA GTAAGAAATA TACTGCTGGG GCCGTGAGCT CCTTGACCAA AT - #GTTCTGGC46800- CAGATTTACA GCATCCTGTA TGGAATGGGT GTGGGAACGG TAGGGAGAGG AT - #GGTACTTC46860- TTAAATCCTG TCAGAAAGTG CTATGATATT GAGGCCACTT TTGCACCCAT GG - #GCATATCT46920- GCCATGCTGG TTGTCATTTT AGTGTACAGG GTTAATAACT GGAGGAGAAA TT - #GACTTTTT46980- CTTCCCCAGT AGCCTGCATA GCACCTTCTG GTATTGTGAA AGCTAGCCAG CA - #GAAAGGAA47040- ACTTCTGGGC CAGGACCAGC GTGATTTCTC CATGTTCTAT GGCCAAAGCA GG - #TGGTGTCT47100- TCAGCAATAC AGCCTTACCA CTAAGTTCTG ATGAGAAACC AAGAACAGTA GC - #GGTGACCT47160- GTATTATTTG AGGTGGGGCA TCTGTAGGAA AAACTGAGCA ACAGTTTGAG AG - #GAGGTATC47220- TCACACTGGA CTATTTGTTT GGTGACCTGT GGCTTCCTTG AGTAACATTA GC - #TTTTATGT47280- AGCCTGATTC CAATTAAACT CTTATATAAG TGTGTGTGAG TTTAGGAAGC TT - #ATAAATAG47340- TAAGTTTCCA TATGGGTTTT AATTTTTTTT TAATTTTATT TTGTGATTTT AC - #TAATTCGC47400- TTTACATCCC GCTCACTGCC CTACTCCTGG TCACTCCCTC CCACAATCCT TT - #CCTTATCC47460- CTCCTCCCCC CTTCTCCTCT GAGAAGTTGG GCCCCCCTGG GTATCCCTCC AC - #CCTGGCAC47520- TTCAAGTCTA TGCGAGGATA GGGTCTTCCT CTCCAATTGA GGCCAGACAA GG - #TAGCCCAG47580- CTAGTAGAAC ATATCCCACG TACGGGCAAC AGCTTTGGGA TAGCCCCCAC TC - #CAGTTGTT47640- TGGGACCCAC ATGAAGACCA AGCTGGACAC CTGCTACATA TGTGTAAGGA AA - #CCTAGCTC47700- CATATGTTCT TTGGTTCGTG GTACAGTTTC TGAGAGCTCC AAGGGTCAGG TT - #AGTTGGCT47760- CTGTTGGTTT TCCTGTGGAG TTCTATCCCT TTCTGGGCTG CAATCCGTCT TC - #CTAGTTTT47820- CCAAGAGTCC CCAAGCTCCA TTCACTGTTT GGCTGTGGGT GTCTGCATCT GT - #CTAAGTCA47880- GCTGCTGTGT GGAGCCTCTC AAAAGACAAC ATGCTCCTGT CTGCAAGCAT AA - #CAGAATAT47940- CATTAATAGT GTCAAGGATT GGTGCTTGCC CATGGGATGG GTCTCAAGTT GG - #ACCGGTTA48000- TTGGTTGGCC ATTCCCTCAG TCTCTGCTCC CTCCCCTGTG CCTATATTAC TT - #GTAGACAG48060- GATAAATTTT GGGTTGATAA TTTTGTGGGT GGGTCAGTGT CTTTATTGCT CT - #ACTTGGGT48120- TGCTGCCTGG CTACAGGAGG TGGCCTCTTC AAGTTCCATA TCCCCAGTGT AG - #TAAGTCAC48180- AGCTAAGGTC ACACCTATTA ATCCTTGGAT GCCTCCCTTA TCCCAGGTTT CT - #GTCTCATC48240- CTGTAAATGC CACCCACTTC CCCACTTTTC CTCTGCAGAT TTCCATTCAT TC - #TCATTACA48300- TCTAGCTCTC TCCCTGCCCT TCCCTACACC CAATCCTGAA CTCCCATCTC CC - #TCCGCATC48360- CCCCGTCCTA GTTCCCTCTT TCCATGTGCC TCTTATAACT ATTTTATTCC CA - #CTTCTAAA48420- TGAGATTCAA GCATCCTTCT GCCTTCCTTC TTGTTTAGCT TCTTTGGGTC TA - #TGGAGTGT48480- ACCATGGTAC TTGTATGTTT TGGCTAATGT CCGCTTATAA GTAAGTACAT AT - #CATGCATC48540- TCCTTTTGGG GTTGGGTCAC CTCACTCAGG ATGATATTCT CAAGTTCCAG CC - #ATTGGCTT48600- GCAAAATTCA TGATGTCTTT CTTTTTAATA GCGGAATGGT ATTCCATTCT GT - #AGATGTAT48660- CACATTTTAT CCATTCTTCA GTTGAGGGAC AGCTAGGTTG TTTCCAGCTT CT - #GGCTATTA48720- TGAATAAAGC TTTAGGAACA TAGTTGGGTA TGTGTCTTTA TGGGATGTTG GA - #GCATCTTT48780- TGGGTATGTG CCCAGGAATG GTATAGCTGG GTCTTGAGGT AGGACTATTC CC - #AGTTTTCT48840- GAGAAACTGC CAAAGTTTCA AGTGGTTGTA TAAGTTCCCC TCACTCCACA CC - #CTTGCCAG48900- CCTGTGTTAT CTTTTGAGTT TTTGATCTTA GCTATTCTGA TGGGTATAAG AT - #GGAACATC48960- AATGTTGTTT TGATTTGCAT TTCCCTCATG ACTAAGGACT TTGAACATTT CT - #CTAAGTGC49020- CTTTCAGCCA TTTGAGAGTC CTCTTTTGAG AATTCTCTGT TTAGCTCTGT TT - #CCCATTTT49080- TAAATTGGGT TATTTGGGTC ATTGTTGTCC AACTTCTTGA ATTCTTCGTA AA - #TTTTAGAT49140- ATTTGCCTTC TGTCCGATGT AGGATTGGTG AAGATTCTTT TCCAATCTGA AG - #ATTGCCTT49200- CTTGTCCTAT TGACAGTGTC CTTTGCCTTA CAGAAGCTTT GCAATTTCTT GG - #GGTCCTAT49260- TTATCAGTTG TTGATCTTAG AGCCTGAGCC ATTGGTGTTC TGTTCAGGAA CT - #TGTCTTCT49320- GTACCAATGC ATTCAAGGTA TTTCCCTCTT TCTCTTCTAT GATATTTAGT GT - #ATATAGTT49380- TTAAGTCGAG GTCTTTCATC CACTTGGACT TGACTCTTTT AATAAATGTG TG - #TGTGTGTG49440- TATGTGTGTG TTTAGGAAGC TTATAAATAG TAAATTTCCA TGTGTTTTTT TT - #AAACTTTT49500- TTTTTTACCT CTCTCTCTCT CCCTACCTCT CCACTCTGCC CTCGCATCCC AC - #TCTACACC49560- TTAAACCTCT TCCCCCTTTA TATCACATAT TGTTCCAGTA TCCCCGTCAT AA - #TGTTTTTT49620- TCTTTCACCT ACCTCTACCA ATAAATGGTC CCTTTCTAGT TTCTTGGATT CT - #TCAGGCAC49680- TCCAAGTTAA ACACACTATG TGAAACATTC AATGGTAGGA TCACATGTGC GA - #ACATGTGA49740- TGATGTTTGT CCTTCTGGGT CTGGGTTCCC TGAATCACTA TTGTTCCCCA GC - #TCCATCAG49800- TTTCCCTGCA AATTGTTATG ATTGTAGTTT TCTTTATAGC CAAATAAAAC GG - #CATTGTGT49860- ATAGGTGGTC CCACACTTTC GTGATCTATT TTGTAATTTA ATGGCTGTTT TC - #ATGTCCTA49920- GCAGTCATGA ACATAGCAGC TAGACCATGG CTGAGCATGC ATCTCTCTGG TA - #GGAAATAG49980- AGGCCTTTGG TTATATACCC AGGGGTGATT TATGTGGGCC ATCGGATTCA TC - #ATTTTAGC50040- TGTTTGAGGA TTCTCTTTAC TGATTTCGAA GGAGCTGCAC CAGCTTTCTG TC - #TCACCAAC50100- GGTGCACAGG GGTTCCCCAG ATCATCACCT GCATTTCTTG TCTTTTATGT TT - #TTTAATCT50160- TATCCTCGAA GTAGTTTCAA CTTGAGTTAA GGATGGTAAA CTCTCCTGAA AG - #CATTTCAT50220- TTCCTAGGCA CCTGCATTTC TTCTTCTGCA ACTTCTGTTT CATTCTATAA CT - #CACTTTTT50280- GTTTTTAGTT TTTTCAACTC TTTTTTGTAT TCTGTAGACT AACCCTCTGT CA - #GATGTGTA50340- GCTGGAATTA TACTCTAGGC TGCTCCTTTG GTCATGTAAT GGTTTCTTTC TT - #AGTAGCAC50400- CTTTTCATTT ATAAAATTCT ATTTGTTGAT TAGTGGTCAT ATTTTGTAGA TG - #ACAGGGCT50460- CCTTTTCAGA GTCCTTACCT GAGCTGGTAT ACTGAGGCAT ACTTCACATT CT - #TCTGGGAG50520- TTTCAGATCT AGCATTGAAA CCTTTGATTT CATTTGGAAT TTATTTGCCA TA - #TCTTACAG50580- GTCCTGGGGA TCCAATCTCA GGTGCTTATA TTTAGACATA GAGCCCTTTG TC - #TCATGAGC50640- TATCTCCCCA ACCCAGATAA TGCTTTTAAG AAAAGATTGG ACCTATTCAG CT - #GTTAGAAC50700- TGTTGATAGA TTTGTGTGTG TATGTGTGTG TGTGTGTGTG TGTGTGTGTG TG - #TACATGTG50760- TGTACCTATA TGCACACATC TGTATGTATC TATTTTAAAG ACAAGATCAT GC - #CTAGGTTG50820- ACTCTCACTC AACTGGAAAT TCTCCTGTCT AAGCCTCCTG ATTACAGCAG TA - #GGATTACA50880- GGCATGTACT ACTATAGTCA ACGGCAATTG CTGTAGTTCT AATCACTCTC CA - #AAGTTATA50940- AGAACATGTA GCTGGGGTGG GCTATTTCGT TTAATTTTCT AGACAAATAT TG - #AGTCTGAT51000- AGAAATATAT TACTATGGGT TAGGTCTGCT TTTCAGGACT AAAGAACTTG GC - #TAAATGCA51060- CAAGGCACTT GGTTCATGAA GAATTACCTA TTGAACCCCT GAAATGGCAG CT - #GGGACTAT51120- CTCTGGACTA TAGGAGCTGG AAAGGGGCAG GGCTGGTGGG AGGAGAAGGT GG - #AGAGGGTA51180- GCTAGGAACT TAAATGTCTT TGAGCTATTG AGCATCTGTT TTTATGTAAG GC - #ATGACATT51240# 51259__________________________________________________________________________

	Number	Date
Parent	632175	Apr 1996
Parent	594242	Jan 1996
Parent	580539	Dec 1995

Genes and gene products related to Werner's syndrome

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CROSS-REFERENCES TO RELATED APPLICATIONS

Non-Patent Literature Citations (7)

Continuation in Parts (3)

Entry
Wall, Theriogenology, vol. 45, pp. 57-68, 1996.
Kappel et al., Current Opinion in Biotechnology, vol. 3, pp. 548-553, 1992.
Srojek & Wagner, Genetic Engineering: Principles and Methods, vol. 10, pp. 221-246, 1988.
Houdebine, Journal of Biotechnology, vol. 34, pp. 269-287, 1994.
Bradley et al., Biotechnology, vol. 10, pp. 534-539, May 1992.
Seki et al., Nucleic Acids Research, vol. 22, pp. 4566-4573, Abstract only, Nov. 11, 1994.
Umezu et al., Proceedings of the National Academy of Sciences, USA, vol. 87, pp. 5363-5367, Abstract only, Jul. 1990.