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GENES THAT CONTROL STEM CELL FREQUENCIES

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Information

  • Research Project
  • 2391524
  • ApplicationId
    2391524
  • Core Project Number
    R01DK052177
  • Full Project Number
    1R01DK052177-01A1
  • Serial Number
    52177
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/1/1997 - 27 years ago
  • Project End Date
    8/31/1998 - 26 years ago
  • Program Officer Name
    BADMAN, DAVID G.
  • Budget Start Date
    9/1/1997 - 27 years ago
  • Budget End Date
    8/31/1998 - 26 years ago
  • Fiscal Year
    1997
  • Support Year
    1
  • Suffix
    A1
  • Award Notice Date
    8/13/1997 - 27 years ago
Organizations
Information

GENES THAT CONTROL STEM CELL FREQUENCIES

DESCRIPTION: The investigators have determined that the LTC-IC assays differ significantly between C57/BL-6, DBA-2 and BALB-c mice. Loci termed Scfr-1 and Scfr-2 are proposed and investigators will focus on positionally cloning these genes and their human homologs. They will do this by generating mouse backcrosses to localize the Scfr genes within 1 Mb fragments. These regions will then be used to evaluate overlapping arrays of yeast and bacterial artificial chromosomes. Definition of the Scfr genes will be based on several criteria such as cDNA selection and expression polymorphisms. In addition, the investigators will analyze which cells in the stem cell hierarchy and at which stages of development strain specific differences are seen and whether or not these are also identified in localized peripheral blood samples.

IC Name
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • Activity
    R01
  • Administering IC
    DK
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    849
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    HEM
  • Study Section Name
    Hematology Subcommittee 2
  • Organization Name
    MEDICAL BIOLOGY INSTITUTE
  • Organization Department
  • Organization DUNS
  • Organization City
    LA JOLLA
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    920371007
  • Organization District
    UNITED STATES