GENETICALLY IDENTICAL RABBITS

Information

• Research Project
• 3421506

• ApplicationId

  3421506

• Core Project Number

  R01RR005269

• Full Project Number

  5R01RR005269-03

• Serial Number

  5269

• FOA Number

• Sub Project Id

• Project Start Date

  9/30/1991 - 33 years ago

• Project End Date

  12/31/1993 - 31 years ago

• Program Officer Name

• Budget Start Date

  9/30/1992 - 32 years ago

• Budget End Date

  12/31/1993 - 31 years ago

• Fiscal Year

  1992

• Support Year

  3

• Suffix

• Award Notice Date

  9/30/1992 - 32 years ago

Organizations

• TSI CORPORATION

The objective of this Phase II proposal is to optimize a procedure for producing a large number of genetically identical rabbits by serial nuclear transplantation. The use of genetically identical rabbits would decrease the number of animals needed for experimentation. Development of a highly efficient nuclear cloning strategy will make it commercially feasible to develop and produce rabbit models for specific human disorders. Over the coming decade, these animals could capture a share of the potentially lucrative market in genetically engineered animal disease models. The optimized protocol will be applied to Watanabe heritable hyperlipidemic (WHHL) rabbits, the only genetic animal model for familial hypercholesterolemia. Reproductive problems currently limited the availability of WHHL rabbits for basic and therapeutic research.

IC Name

• Activity

  R01

• Administering IC

  RR

• Application Type

  5

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  306

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  REN

• Study Section Name

  Reproductive Endocrinology Study Section

• Organization Name

  TSI CORPORATION

• Organization Department

• Organization DUNS

• Organization City

  MILFORD

• Organization State

  MA

• Organization Country

  UNITED STATES

• Organization Zip Code

  01757

• Organization District

  UNITED STATES