Genomics of Antibiotic Resistance in Bacterial Pathogens

Information

  • Research Project
  • 9032438
  • ApplicationId
    9032438
  • Core Project Number
    U19AI110819
  • Full Project Number
    5U19AI110819-03
  • Serial Number
    110819
  • FOA Number
    RFA-AI-13-009
  • Sub Project Id
    6908
  • Project Start Date
    -
  • Project End Date
    -
  • Program Officer Name
  • Budget Start Date
    4/1/2016 - 8 years ago
  • Budget End Date
    3/31/2017 - 7 years ago
  • Fiscal Year
    2016
  • Support Year
    03
  • Suffix
  • Award Notice Date
    3/9/2016 - 8 years ago

Genomics of Antibiotic Resistance in Bacterial Pathogens

Emerging antibiotic resistance is making treatment of infections caused by Acinetobacter baumannii, Klebsiella pneumoniae and other Enterobacteriaceae increasingly ineffective. Many resistance genes are carried on mobile genetic elements and can readily be exchanged between strains and species. This project will use comprehensive genome analysis to improve our understanding of the genetic context of resistance genes, their chromosomal background, and lateral gene transfer. Properties of the drug resistance element transmission process in populations will be analyzed using historical and ongoing collections of isolates from several hospitals. Additional studies are designed to explore the role of mixed infections in genetic exchange and the relationship of pathogens to commensal bacteria in the microbiome. The scope and extent of DNA methylation in A. baumannii and K. pneumoniae will be analyzed using single molecule real time sequencing and the effect on gene expression will be determined. The results should be of value in development of molecular assays to facilitate diagnosis and selection of appropriate therapies for clinical infections.

IC Name
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
  • Activity
    U19
  • Administering IC
    AI
  • Application Type
    5
  • Direct Cost Amount
    739017
  • Indirect Cost Amount
    690520
  • Total Cost
  • Sub Project Total Cost
    1429537
  • ARRA Funded
    False
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
    NIAID:1429537\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    ZAI1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    J. CRAIG VENTER INSTITUTE, INC.
  • Organization Department
  • Organization DUNS
    076364392
  • Organization City
    ROCKVILLE
  • Organization State
    MD
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    208503343
  • Organization District
    UNITED STATES