Claims
- 1. A stable pharmaceutical formulation comprising a GLP-1 compound selected from the group consisting of: GLP-1, GLP-1 analogs, and GLP-1 derivatives wherein the GLP-1 compound can bind to the GLP-1 receptor, complexed with an anionic surfactant selected from the group consisting of docusate sodium, docusate calcium, docusate potassium, sodium dodecyl sulfate, sodium caprylate, sodium cholate, sodium deoxycholate, sodium taurocholate, and sodium glycocholate and a preservative wherein the stable formulation is a solution and has a pH between about 6.5 and about 9.0.
- 2. The formulation of claim 1, wherein the GLP-1 compound is a GLP-1 derivative.
- 3. The formulation of claim 2, wherein the GLP-1 derivative is a GLP-1 analog having an acylated lysine ε-amino group.
- 4. The formulation of claim 1, wherein the GLP-1 compound has an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:4, and SEQ ID NO:5, or pharmaceutically acceptable salts thereof.
- 5. The formulation of claim 1 further comprising an isotonicity agent.
- 6. The formulation of claim 1 wherein the anionic surfactant is docusate sodium.
- 7. The formulation of claim 6 wherein the GLP-1 compound is complexed with docusate sodium and has an altered secondary structure compared to the uncomplexed GLP-1 compound.
- 8. The formulation of claim 7 wherein the GLP-1 compound comprises the sequence of SEQ ID NO:5.
- 9. The formulation of claim 1 wherein the molar ratio of anionic surfactant to GLP-1 compound is between about 0.1:1 and about 50:1.
- 10. The formulation of claim 9 wherein the molar ratio is about 2:1.
- 11. A method of treating a person having a condition for which administration of a GLP-1 compound is indicated, said method comprising administering a pharmacologically effective amount of a formulation of claim 1.
RELATED APPLICATIONS
This application is a continuation of International Application Serial No. PCT/US98/25515, filed Dec. 2, 1998, which claims the benefit of U.S. Provisional Application No. 60/067,600, filed Dec. 5, 1997. The entire teachings of these prior applications are incorporated herein by reference.
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Provisional Applications (1)
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Number |
Date |
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|
60/067600 |
Dec 1997 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
PCT/US98/25515 |
Dec 1998 |
US |
Child |
09/585181 |
|
US |