Claims
- 1. A compound of the formula ##STR3## wherein R is methyl and X is Cl, or Br, or R is ethyl and X is Cl, Br, N.sub.3 or CN.
- 2. The compound of claim 1 which is 17.alpha.-azidomethyl-17.beta.-hydroxy-13.beta.-ethyl-gona-4,9(10)-diene-3-one.
- 3. The compound of claim 1 which is 17.alpha.-bromomethyl-17.beta.-hydroxy-13.beta.-methyl-gona-4,9(10)-diene-3-one.
- 4. A process for producing gona-4,9(10)-dienes comprising
- (a) opening up a 3-methoxy-13.beta.-R-gona-2,5(10)-diene-17.beta.-spiro-1',2'-oxirane of the formula ##STR4## by reaction with a nucleophilic agent selected from the group consisting of hydrobromic acid, hydrochloric acid, sodium azide, alkali cyanides, ammonia and primary or secondary amines in an organic solvent so as to form the corresponding 3-methoxy-17.alpha.-CH.sub.2 X-13.beta.-R-gona-2,5(10)-diene-17.beta.-ol of the formula ##STR5## then (b) hydrolyzing the latter compound with a slightly acidic catalyst constituted by a weak organic carboxylic acid in dilute aqueous solution or by a dilute mineral acid whereby the 17.beta.-hydroxy-17.alpha.-CH.sub.2 X-13.beta.-R-gona-5(10)-ene-3-ol of the formula ##STR6## is formed, thereafter (c) converting the latter compound by reaction with a halogenating agent into the 5,10-dihalogenated compound, and
- (d) subjecting the dihalogenated compound to dehydrohalogenation, thereby forming a 17.beta.-hydroxy-17.alpha.-CH.sub.2 X-13.beta.-R-gona-4,9(10)-diene-3-one, wherein R is methyl or ethyl and X is Br, Cl, N.sub.3 or CN.
- 5. The process of claim 4 wherein the reaction is performed under neutral or alkaline conditions.
- 6. The process of claim 4 wherein the organic solvent is a lower alcohol, ethylene glycol, ether, ethylene glycol ether, dimethylsulphoxide, or dimethylformamide.
- 7. The process of claim 4 wherein the reaction with the nucleophilic agent is carried out in a slightly acid medium and the hydrolysis of the enol ether group in the 3-position is simultaneously carried out with the opening up of the epoxide group and introduction of the 17.alpha.-CH.sub.2 X group.
- 8. The process of claim 4 wherein the hydrolysis is performed in the presence of the slightly acidic medium in an organic solvent that is miscible with water or in a solvent mixture between water, a water-miscible solvent and a nonwater-miscible solvent.
- 9. The process of claim 8 wherein the hydrolysis reaction is carried out in an alcohol, dioxane, acetone, a mixture of water with methanol and benzene or a mixture of water with tertiary butanol and methylene chloride.
- 10. The process of claim 4 wherein the catalyst for the hydrolysis is acetic acid, oxalic acid, citric acid, succinic acid, dilute hydrobromic acid or dilute perchloric acid.
- 11. The process of claim 4 wherein the halogenating reaction is carried out by reaction with bromine or a perbromide in a chlorinated aliphatic hydrocarbon solvent or a tertiary organic nitrogen containing base.
- 12. The process of claim 4 wherein the halogenating reaction is carried out in the presence of phenyltrimethylammoniumperbromide or pyridiniumperbromide at a temperature between -5.degree. and +10.degree. C. in an inert solvent.
- 13. The process of claim 12 wherein the solvent is a chlorinated aliphatic hydrocarbon or a tertiary organic nitrogenous base.
- 14. The process of claim 14 wherein the dehydrohalogenation is carried out by reaction with a tertiary organic base at room temperature or a slightly elevated temperature.
- 15. The process of claim 14 wherein the tertiary organic base is pyridine, a picoline, collidine or ethyl pyridine.
- 16. A process as defined in claim 4, wherein in the reaction at (a) the solution is formed in dimethylformamide, methylene chloride, ether or dimethylsulfide as solvent, whereupon the solution is subjected to the action of hydrochloric acid or hydrobromic acid before adding the acid catalyst for the hydrolysis reaction.
- 17. A process as defined in claim 4, wherein the reaction with the nucleophilic agent is carried out at a temperature of between about 20.degree. and 100.degree. C. in the presence of a weak acid as catalyst.
Priority Claims (1)
Number |
Date |
Country |
Kind |
193348 |
Jun 1976 |
DEX |
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Parent Case Info
This is a continuation, of application Ser. No. 816,871, filed July 18, 1978, which in turn is a continuation-in-part of application Ser. No. 806,471, filed June 14, 1977, both now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3502699 |
Hughes et al. |
Mar 1970 |
|
3931154 |
Phillippson et al. |
Jan 1976 |
|
4029648 |
Ponsold et al. |
Jun 1977 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
816871 |
Jul 1978 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
806471 |
Jun 1977 |
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