Claims
- 1. A compound having the following structure:
- 2. The compound of claim 1 wherein R4 is substituted arylalkyl or substituted heteroarylalkyl.
- 3. The compound of claim 1 wherein R5 is substituted aryl or substituted heteroaryl.
- 4. The compound of claim 1 wherein n is 2 or 3.
- 5. The compound of claim 4 wherein R4 is substituted arylalkyl or substituted heteroarylalkyl.
- 6. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or diluent.
- 7. A method for antagonizing gonadotropin-releasing hormone in a subject in need thereof, comprising administering to the subject an effective amount of a compound of claim 1.
- 8. A method for treating a sex-hormone related condition of a subject in need thereof, comprising administering to the subject an effective amount of the pharmaceutical composition of claim 6.
- 9. The method of claim 8 wherein the sex-hormone related condition is cancer, benign prostatic hypertrophy or myoma of the uterus.
- 10. The method of claim 9 wherein the cancer is prostatic cancer, uterine cancer, breast cancer or pituitary gonadotroph adenomas.
- 11. The method of claim 8 wherein the sex-hormone related condition is endometriosis, polycystic ovarian disease, uterine fibroids or precocious puberty.
- 12. A method for preventing pregnancy of a subject in need thereof, comprising administering an effective amount of the pharmaceutical composition of claim 6.
- 13. A method for treating lupus erythematosis, irritable bowel syndrome, premenstrual syndrome, hirsutism, short stature or sleep disorders of a subject in need thereof, comprising administering to the subject an effective amount of the pharmaceutical composition of claim 6.
CROSS-REFERENCES TO RELATED APPLICATIONS
[0001] This application is a continuation of U.S. application Ser. No. 10/211,955 filed Aug. 2, 2002, which claims the benefit of U.S. Provisional Patent Application No. 60/310,018 filed Aug. 2, 2001, which applications are incorporated herein by reference in their entirety.
STATEMENT OF GOVERNMENT INTEREST
[0002] Partial funding of the work described herein was provided by the U.S. Government under Grant No. R43-HD38625 provided by the National Institutes of Health. The U.S. Government may have certain rights in this invention.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60310018 |
Aug 2001 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
10211955 |
Aug 2002 |
US |
Child |
10705723 |
Nov 2003 |
US |