Claims
- 1. An external circulation apparatus for in vivo improvement of the granulocyte to lymphocyte ratio in a flow of blood continuously removed from a subject and continuously returned to the subject after improvement of the granulocyte to lymphocyte ratio, said apparatus having a device for contacting the blood with a career for decreasing the granulocyte to lymphocyte ratio in blood, comprising:
- a) a granulocyte-adsorbing portion enclosing therein cellulose acetate beads having higher affinity for granulocytes than for lymphocytes;
- b) a blood inflow port for causing blood to flow into the adsorbing portion;
- c) a blood outflow port for allowing the blood, which has flowed into the adsorbing portion, to flow out of the adsorbing portion,
- d) a circulation loop, downstream of said blood outflow port, for the blood exiting from said blood outflow port, including arterial and venous pressure gauges; and
- e) blood pumping means.
- 2. The apparatus of claim 1, wherein the beads have a diameter of from 0.1 to 10 mm.
- 3. The apparatus of claim 1, wherein said blood inflow portion allows blood to be continuously supplied to the adsorbing portion.
- 4. The apparatus of claim 1, wherein said blood inflow portion allows blood to be supplied to the adsorbing portion in every batch.
- 5. The apparatus of claim 1, wherein the beads have a diameter of from 0.5 mm to 7 mm.
Priority Claims (2)
Number |
Date |
Country |
Kind |
62-313027 |
Dec 1987 |
JPX |
|
63-267947 |
Oct 1988 |
JPX |
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Parent Case Info
This is a Division, of application Ser. No. 08/257,572, filed on JUN. 9, 1994, now U.S. Pat. No. 5,403,719, which is a continuation of application Ser. No. 07/829,525, filed on FEB. 3, 1992, abandoned, which is a continuation of application Ser. No. 07/609,120, filed on NOV. 2, 1990, abandoned, which is a continuation of application Ser. No. 07/282,216, fled on DEC. 9, 1988, abandoned.
US Referenced Citations (8)
Divisions (1)
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257572 |
Jun 1994 |
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Continuations (3)
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829525 |
Feb 1992 |
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609120 |
Nov 1990 |
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282216 |
Dec 1988 |
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