GROWTH-ASSOSCIATED PROTEINS

Information

  • Research Project
  • 3504676
  • ApplicationId
    3504676
  • Core Project Number
    R43NS031073
  • Full Project Number
    1R43NS031073-01
  • Serial Number
    31073
  • FOA Number
  • Sub Project Id
  • Project Start Date
    8/20/1992 - 32 years ago
  • Project End Date
    8/19/1993 - 31 years ago
  • Program Officer Name
  • Budget Start Date
    8/20/1992 - 32 years ago
  • Budget End Date
    8/19/1993 - 31 years ago
  • Fiscal Year
    1992
  • Support Year
    1
  • Suffix
  • Award Notice Date
    8/19/1992 - 32 years ago

GROWTH-ASSOSCIATED PROTEINS

The objective of this project is to examine the molecular changes that underlie spinal cord regeneration in the lamprey. We will identify and isolate novel growth-associated proteins (GAPS) derived from the central nervous system that are expressed during the course of normal development and subsequent to CNS injury. In higher vertebrates, GAPs are known to be expressed in greater than normal quantities during periods of axonal outgrowth and in response to injury. The search for GAPs derived from the CNS of the sea lamprey represents a potentially valuable avenue of research as lampreys are the only vertebrates to demonstrate functional recovery following complete spinal cord transection. Therefore, the GAPs expressed in this species could provide unique tools for the investigation of the mechanisms of both normal axonal outgrowth and nerve regeneration. During Phase I we will develop a novel in vitro isolated neuraxis preparation that takes advantage of the unique features of lamprey CNS physiology. This preparation will be used in conjunction with two-dimension (2-D) gel electrophoresis of radiolabeled proteins, as it has been employed successfully in the past in the identification and isolation of GAPs found in many other vertebrate species.

IC Name
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
  • Activity
    R43
  • Administering IC
    NS
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    853
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    BPO
  • Study Section Name
    Biopsychology Study Section
  • Organization Name
    CAMBRIDGE NEUROSCIENCE
  • Organization Department
  • Organization DUNS
  • Organization City
    NORWOOD
  • Organization State
    MA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    02062
  • Organization District
    UNITED STATES