GSH RECEPTOR PROBES TO STUDY CNS DEVELOPMENT/DYSFUNCTION

Information

• Research Project
• 2270259

• ApplicationId

  2270259

• Core Project Number

  R44NS032234

• Full Project Number

  2R44NS032234-02

• Serial Number

  32234

• FOA Number

• Sub Project Id

• Project Start Date

  3/1/1994 - 30 years ago

• Project End Date

  1/31/1997 - 27 years ago

• Program Officer Name

• Budget Start Date

  3/1/1995 - 29 years ago

• Budget End Date

  2/29/1996 - 28 years ago

• Fiscal Year

  1995

• Support Year

  2

• Suffix

• Award Notice Date

  2/27/1995 - 29 years ago

Organizations

• COVALENT ASSOCIATES, INC.

During the Phase I project, the PI has prepared florescent glutathione probes for the study of glutathione (GSH) receptors in the CNS. One of these probes shows promise as a potential replacement for radiolabelled GSH for the study of these receptors. In the Phase II portion of the project, the PI plans to continue preparation of such fluorescent probes with an ultimate aim toward not only maximizing the binding parameters for the GSH receptor but also with the aim of identifying that portion of the molecule which contributes to the binding to the receptor. In addition, the probes prepared by the PI will be used for comparison with radiolabelled GSH as a probe for studying the GSH receptor in astrocytes and/or human spinal cord.

IC Name

• Activity

  R44

• Administering IC

  NS

• Application Type

  2

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  853

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ZRG1

• Study Section Name

• Organization Name

  COVALENT ASSOCIATES, INC.

• Organization Department

• Organization DUNS

• Organization City

  WOBURN

• Organization State

  MA

• Organization Country

  UNITED STATES

• Organization Zip Code

  01801

• Organization District

  UNITED STATES