Claims
- 1. A compound comprising a β-substituted calix[n]pyrrole macrocycle having structure I:
- 2. The compound of claim 1 wherein n is 4 and p=q=r=s=0.
- 3. The compound of claim 1 wherein at least two R substituents are coupled to form a bridged structure, the two R substituents selected from the group consisting of an odd numbered R substituent and a pyrrole R substituent, and when coupled to form a bridged structure, nonbridged substituents are as defined.
- 4. A compound comprising a β-substituted calix[n]pyrrole macrocycle having structure I:
- 5. A composition comprising the compound of claim 1 incorporated into a polymer matrix.
- 6. A composition comprising the compound of claim 1 incorporated into a membrane.
- 7. A composition comprising the compound of claim 1 incorporated into a liposome.
- 8. A compound comprising a fluorinated calix[n]pyrrole where n is 9, 10, 11, or 12.
- 9. The compound of claim 1 wherein n is 5.
- 10. The compound of claim 1 wherein n is 6 or 7.
- 11. The compound of claim 1 wherein n is 8.
- 12. A method of making a halogenated calix[n]pyrrole where n is 4, 5, 6, 7, 8, 9, 10, 11, or 12 comprising
reacting 3,4-dihalopyrrole and a ketone molecule for a time sufficient to produce the halogenated calix[n]pyrrole.
- 13. The method of claim 12 wherein the halogenated calix[n]pyrrole is a fluorinated calix[n]pyrrole and the 3,4-dihalopyrrole is a 3,4-difluoropyrrole.
- 14. A method of removing an anion from an environment containing the anion comprising contacting the environment with a halogenated calix[n]pyrrole where n is 4, 5, 6, 7, or 8 wherein the halogenated calix[n]pyrrole binds the anion thereby removing the anion from the environment.
- 15. The method of claim 14 wherein the anion is an environmental pollutant.
- 16. The method of claim 14 wherein the anion is fluoride, chloride, or phosphate.
- 17. The method of claim 14 wherein the anion is pertechnetate.
- 18. A method for extracting an ion pair having a cation associated with an anion from an environment containing said ion pair, the method comprising contacting the environment with an anion coextractant and a cation coextractant, wherein the anion coextractant is a calix[n]pyrrole where n is 4, 5, 6, 7, or 8, and wherein the calix[n]pyrrole binds the anion and the cation coextractant binds the cation thereby allowing for removal of the ion pair from the environment.
- 19. The method of claim 18 wherein the calix[n]pyrrole is a halogenated calix[n]pyrrole.
- 20. The method of claim 18 wherein the calix[n]pyrrole is a fluorinated calix[n]pyrrole.
- 21. The method of claim 18 wherein the ion pair is an environmental pollutant.
- 22. The method of claim 18 wherein the cation coextractant is a crown ether, a cryptand, a calixarene, a calixarene-crown ether cryptand, or a calixarene-crown ether conjugate.
- 23. The method of claim 18 wherein the cation coextractant is a cation exchanger.
- 24. A method for reducing or preventing corrosion on a substrate susceptible to corrosion in the presence of a corrosion-promoting anion, comprising contacting the substrate with a calix[n]pyrrole where n is 4, 5, 6, 7, or 8 wherein the calix[n]pyrrole binds the corrosion-promoting anion, thereby reducing or preventing corrosion of the substrate.
- 25. The method of claim 24 wherein the calix[n]pyrrole is a halogenated calix[n]pyrrole.
- 26. The method of claim 24 wherein the calix[n]pyrrole is a fluorinated calix[n]pyrrole.
- 27. The method of claim 24 wherein the substrate is gasoline or jet fuel and the anion is a chloride anion.
- 28. A method for producing a naked cation in a solution containing said cation paired with an anion, the method comprising contacting a calix[n]pyrrole where n is 4, 5, 6, 7, or 8 with the solution, wherein the calix[n]pyrrole binds the anion thereby providing the naked cation.
- 29. The method of claim 18 wherein the cation is cesium.
- 30. A compound selected from the group consisting of compounds 44, 46, 48, 50, and 52.
Parent Case Info
[0001] The present application is a continuation-in-part application of copending U.S. Ser. No. 09/838,998 filed Apr. 20, 2001, which is a divisional of U.S. Ser. No. 08/833,379 filed Apr. 4, 1997, now U.S. Pat. No. 6,262,257 B1, which claims priority to U.S. Ser. No. 60/014,890 filed Apr. 5, 1996; U.S. Ser. No. 60/024,203 filed Aug. 27, 1996; U.S. Ser. No. 60/026,694 filed Sep. 25, 1996; U.S. Ser. No. 60/033,395 filed Dec. 17, 1996; and U.S. Ser. No. 60/033,396 filed Dec. 17, 1996.
Government Interests
[0002] The government owns certain rights in the present invention pursuant to grant number CHE9725399 from The National Science Foundation and GM58907 from The National Institutes of Health.
Provisional Applications (5)
|
Number |
Date |
Country |
|
60014890 |
Apr 1996 |
US |
|
60024203 |
Aug 1996 |
US |
|
60026694 |
Sep 1996 |
US |
|
60033395 |
Dec 1996 |
US |
|
60033396 |
Dec 1996 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
08833379 |
Apr 1997 |
US |
Child |
09838998 |
Apr 2001 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09838998 |
Apr 2001 |
US |
Child |
09939514 |
Aug 2001 |
US |