Patent Application
20070196359
The present invention relates to biocides. More particularly, the present invention relates to a halide substituted N-succinimide solution in an acidic pH range that is an effective high level disinfectant.
A biocide is a chemical substance capable of killing different forms of living organisms. Examples of biocides include pesticides, fungicides, herbicides, insecticides, miticides, or rodenticides. In particular, biocides can be used to prevent or protect against biological infestation and growth and to disinfect surfaces, instruments, etc. For example, certain types of materials can be added to pool water or industrial water systems to act as an algicide. In other cases, articles, such as medical devices, can be disinfected. For disinfection, desirable characteristics may include rapid effectiveness against bacterial spores, mycobacteria, vegetative bacteria, viruses, in addition to other undesirable organisms, such as fungi.
Known biocides used to disinfect medical devices may include aldehydes or dialdehydes such as formaldehyde, glutaraldehyde, or o-phthaldehyde (also known as OPA) and peroxy acid compounds such as peracetic acid. Unfortunately, many of these materials have undesirable properties. Formaldehyde is potentially carcinogenic and has an objectionable odor. Glutaraldehyde also has an objectionable odor and may be volatile and chemically unstable during storage. OPA may undesirably stain certain surfaces black, such as skin, hair, clothing, gloves and other materials.
Typically, many solid compounds having biocidal activity are used in solution by dissolving them into suitable liquids, for example, glycols, glycol ethers, aprotic polar solvents, water, or a mixture of these solvents with water. Liquidizing biocidal solid compounds in this manner provides these compounds with excellent workability at the time of use. However, when certain biocides are prepared as liquid solutions a volume of irritant corrosive gas may be generated. Further, the biocidal active ingredients may be deactivated within a very short period of time.
There is therefore a continual need for effective agents with biocidal properties.
One embodiment of the present invention includes an aqueous biocide composition wherein the composition includes an N-halosuccinimide or derivative thereof, a succinimide or a derivative thereof, an anticorrosive agent, and an aqueous carrier, wherein the aqueous composition has a pH in the range of less than about 6.
In one embodiment of the present invention the biocide may be an N-halosuccinimide of the formula:
wherein:
In a further embodiment of the present invention the N-halosuccinimide may be a substituted or unsubstituted aromatic ring structure that forms the structure:
wherein:
The biocide composition may be an N-chlorosuccinimide or the N-bromosuccinimide compound or a derivative thereof.
In still further embodiments the biocide composition may include 0.1 to 3% of the N-halosuccinimide composition.
The biocide composition may further include a stabilizer of succinimide or a derivative thereof wherein the stabilizer comprises approximately 0.2 -10% of the overall composition.
In further embodiments the biocide composition may include an anticorrosive selected from the group consisting of triazoles, alkylamines, and ethoxylates.
In further embodiments the anticorrosive agent may be 0.01-1% of the composition.
In still further embodiments the pH may be in the range of about 2 to about 6.
In still further embodiments the biocide composition may include one or more of the group consisting of surfactants, cosolvents, colorants, odorants, and buffers.
Still further embodiments of the present invention include a method of sterilizing a surface by contacting a surface with a biocide composition for a time to sufficient to kill 106 mycobacteria and/or 106 bacterial endospores and rinsing the surface to remove residual biocide composition.
While multiple embodiments are disclosed, still other embodiments of the present invention will become apparent to those skilled in the art from the following detailed description, which shows and describes illustrative embodiments of the invention. The present invention is capable of modifications in various obvious aspects, all without departing from the spirit and scope of the present invention. Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not restrictive.
The present invention relates generally to a novel biocide that can be used to formulate a high level disinfection (HLD) material. The biocide may be provided as a solution that is generally odorless and non-staining. The biocide may be utilized to sterilize or disinfect surfaces, medical devices, fermentors and clean rooms. Medical devices that may be sterilized or disinfected may include endoscopes, hemodialysis equipment, dental equipment, and inhalation equipment. The present composition may also be useful in other sterilization and disinfection solutions and methods and may be used to sterilize other surfaces and medical devices.
One embodiment of the present invention biocide composition generally includes a halide substituted N-succinimide (also described in this specification as an N-halosuccinimide) in addition to a stabilizer, an anticorrosive agent, and an aqueous carrier.
The N-succinimide may be of the following general formula:
wherein:
Another example of the halide substituted N-succinimide may be, for example:
wherein:
The halide substituted N-succinimide may be used as a liquid biocide, and, in particular, as a microbicide. In one embodiment, the N-halosuccinimide of the biocide may be N-bromosuccinimide (NBS) and may be provided in an aqueous solution wherein the NBS is in the range of about 0.1% to about 2.8% by weight (all percentages herein being by weight unless otherwise specified). In further embodiments the NBS may be in the range of about 0.5 to 1.5% and up to about 3%, if acetic acid buffer is used due to an increase in the solubility of NBS in the buffered solution. In another embodiment the N-halosuccinimide may be N-chlorosuccinimide (NCS) and may be provided in an aqueous solution in the range of about 0.1% to about 1.8%. In further embodiments the NCS may be in the range of about 0.5 to about 1.5%. The aqueous biocide solution that results from the addition of the halide substituted N-succinimide may have a pH between approximately 2 and 6. In further embodiments the pH may be adjusted as desired. In addition, the percent of the N-succinimide in the biocide solution may also be increased or decreased as desired.
In one embodiment the stabilizer may be added to push the equilibrium of the N-succinimide in the biocide solution towards the bound oxy-halide. The stabilizer may include succinimide added to the biocide solution at approximately 1% to 10.0%. In other embodiments the stabilizer may be added in a greater or lesser amount depending on the stabilization needs and the stabilizer material. Other stabilizers may include, for example, hydantoins, alkyl or aryl sulfamides such as toluenesulfamide, benzamide, methanesulfamide and urea, thiophenes, indoles or sodium diacetate.
In one embodiment the anticorrosive agent may be added to the biocide solution such that it represents about 0.01 to about 1% of the biocide solution. One useful anticorrosive agent may be benzotriazole, which may be added to the biocide solution at about 0.01% to about 0.5%. Another class of useful anticorrosive agents may be the Mazon RI corrosion inhibitors (BASF), such as Mazon RI 246, which may be added to the biocide solution at about 0.04% to 0.5%. Another useful anticorrosive agent may be sodium ethoxylate, which may be added to the biocide solution at about 0.1% to 0.5%.
In still further embodiments a buffer may be added to the biocide solution. Suitable buffers include acetate, phosphate, citrate and Good Buffers such as MOPS, MES, HEPES, PIPES, and EPPS. See N. E. GOOD et al., Biochemistry 5 467-477 (1966) and W. J. Ferguson et al., Analytical Biochemistry 104 300-310 (1980).
One embodiment of the aqueous biocide solution of the present invention biocide may include:
The resultant pH of this biocide solution is approximately 3. The mixture is prepared by preparing an acetate buffer at pH 3 and then dissolving each of the other components to the specified concentrations.
As illustrated in
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As illustrated in
Further testing on the corrosion rate of brass was also performed with the addition of succinimide as a stabilizer. The succinimide stabilizer was added in different amounts between 0.0% and 9.5% and the tests were again run at 25° C. according to ASTM standard G31-72 (04) guidelines. The results are shown in
Additional testing was performed on the corrosion rate of embodiments of the present invention with the addition of anticorrosive agents. As illustrated in
As is also shown in
Various modifications and additions can be made to the exemplary embodiments discussed without departing from the scope of the present invention. Accordingly, the scope of the present invention is intended to embrace all such alternatives, modifications, and variations as fall within the scope of the claims, together with all equivalents thereof.
