Claims
- 1. A hard gelatin capsule which comprises gelatin and titanium oxide having a secondary particle size of less than 10 μm and a median diameter of 0.5 μm or less being dispersed in the gelatin.
- 2. The capsule according to claim 1, wherein the amount of the titanium oxide is 10% by weight or less based on the amount of the gelatin.
- 3. The capsule according to claim 1, wherein the amount of the titanium oxide is 7.5% by weight or less based on the amount of the gelatin.
- 4. The capsule according to claim 1, wherein the secondary particle size of the titanium oxide is 0.1 to 9 μm and the median diameter of the same is within the range of 0.1 to 0.5 μm.
- 5. The capsule according to claim 1, wherein the secondary particle size of the titanium oxide is 0.1 to 7 μm and the median diameter of the same is within the range of 0.2 to 0.45 μm.
- 6. The capsule according to claim 1, wherein the capsule further comprises 3% by weight or less of polyethylene glycol based on the amount of the gelatin.
- 7. The capsule according to claim 6, wherein the molecular weight of the polyethylene glycol is 200 to 20,000.
- 8. The capsule according to claim 6, wherein the molecular weight of the polyethylene glycol is 1,000 to 6,000.
- 9. The capsule according to claim 6, wherein the molecular weight of the polyethylene glycol is 2,000 to 5,000.
- 10. The capsule according to claim 6, wherein the molecular weight of the polyethylene glycol is 2,600 to 3,800.
- 11. The capsule according to claim 6, wherein the capsule comprises 89.6 to 96.99% by weight of gelatin, 3 to 7.5% by weight of titanium oxide and 0.01 to 2.9% by weight of polyethylene glycol.
- 12. A process for producing a hard gelatin capsule which comprises the steps of preparing a gelatin solution, dispersing titanium oxide in the gelatin solution so that a secondary particle size of the titanium oxide becomes less than 10 μm and a median diameter of the same becomes 0.5 μm or less, and molding the dispersion to prepare a capsule.
- 13. The process according to claim 12, wherein dispersing step of the titanium oxide is carried out at 7,000 rpm or more for 20 minutes to 5 hours.
- 14. The process according to claim 12, wherein dispersing step of the titanium oxide is carried out after mixing a previously prepared polyethylene glycol solution with the gelatin solution.
CROSS-REFERENCE TO RELATED PATENT APPLICATIONS
[0001] The present application claims the benefit of priority under 35 U.S.C. §119 (e) from U.S. Provisional Patent Application No. 60/471,583 (“HARD GELATIN CAPSULE AND PROCESS FOR PRODUCING THE SAME”) filed May 19, 2003 (the entirety of which is incorporated by reference).
Provisional Applications (1)
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Number |
Date |
Country |
|
60471583 |
May 2003 |
US |