Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60

Information

  • Research Project
  • 9969287
  • ApplicationId
    9969287
  • Core Project Number
    R01AG052519
  • Full Project Number
    5R01AG052519-04
  • Serial Number
    052519
  • FOA Number
    PA-13-302
  • Sub Project Id
  • Project Start Date
    9/15/2017 - 7 years ago
  • Project End Date
    5/31/2022 - 2 years ago
  • Program Officer Name
    PHILLIPS, JOHN
  • Budget Start Date
    6/1/2020 - 4 years ago
  • Budget End Date
    5/31/2021 - 3 years ago
  • Fiscal Year
    2020
  • Support Year
    04
  • Suffix
  • Award Notice Date
    9/3/2020 - 4 years ago

Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60

7. Project Summary/Abstract The unrivalled increase in human life expectancy over the last century has been one of the greatest achievements of public health medicine. However, it also poses new and unique challenges in health and social care, in particular the increased burden of chronic diseases and associated ageing states, including cognitive impairment and frailty. Understanding the occurrence and determinants of these ageing outcomes has become a global research priority with considerable policy implications. Several studies have been established in middle- and older-aged populations in the US (HRS, MIDUS) with the capacity to offer much- needed insights into these issues. However, it has recently become evident that the processes that underlie ageing states begin much sooner in the life course than originally thought, in some cases as early as birth or preconception. It is in such life course-orientated studies that the USA is surprisingly bereft. The 1958 British Birth Cohort Study in the UK is the largest long-running study of this genre. With the study members approaching 60 years of age, when problems of ageing begin to emerge with frequency, we will carry out a detailed phenotypic and genotypic survey which covers an array of areas including biological, psychological, socioeconomic and behavioural characteristics. Uniquely, these new data will allow us to answer a series of important research questions of public health importance, ranging from identifying the policy-modifiable behaviours and biological mechanisms in mid-life that successfully reverse the effects of earlier life exposures and adversities on ageing outcomes, through to examining the long term influence of early life educational interventions on social, health, and ageing outcomes in older age, on to running a series of cross-country, and cross-cohort comparisons, to enable us to highlight where such processes are changing across generations, or between countries. These data will become publically available to bone fide population scientists soon after collection, so providing an unrivalled resource for the scientific community to investigate a range of policy- relevant issues.

IC Name
NATIONAL INSTITUTE ON AGING
  • Activity
    R01
  • Administering IC
    AG
  • Application Type
    5
  • Direct Cost Amount
    300406
  • Indirect Cost Amount
    22848
  • Total Cost
    323254
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    866
  • Ed Inst. Type
  • Funding ICs
    NIA:323254\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    SSPA
  • Study Section Name
    Social Sciences and Population Studies A Study Section
  • Organization Name
    UNIVERSITY COLLEGE LONDON
  • Organization Department
  • Organization DUNS
    225410919
  • Organization City
    LONDON
  • Organization State
  • Organization Country
    UNITED KINGDOM
  • Organization Zip Code
    WC1E 6BT
  • Organization District
    UNITED KINGDOM