Claims
- 1. In a method of purifying the blood of a patient, wherein said blood contains desirable proteins along with impurities including .beta..sub.2 -microglobulins and wherein said blood is subjected to the action of a dialysis membrane which removes impurities from the blood, the steps which comprise:
- (a) subjecting said blood to a dialysis procedure controlled to remove impurities but to retain desirable proteins in the blood,
- (b) controlling the dialysis to cause removal from the blood of .beta..sub.2 -microglobulin at a reduction rate of 5% or more while impeding significant losses of said desirable proteins, and
- (c) said membrane having a total protein permeability of 0.2% or less, a .beta..sub.2 -microglobulin reduction rate of 5% or more, a total volume porosity of 35 to 75% and a pore volume porosity of 25% or more, said membrane including an active layer portion having pore radii of 4-15 nm.
- 2. The method defined in claim 1, wherein said membrane is porous and the pore radius of the pores in its active layer is 4 nm to 10 nm.
- 3. The method defined in claim 1, wherein said membrane is porous and the pore radius of the pores in its active layer is 5.5 nm to 0.5 nm.
- 4. The method defined in claim 1, wherein said reduction rate is about 5-50%.
- 5. The method defined in claim 1, wherein said reduction rate is about 10-50%.
- 6. The method defined in claim 1, wherein said reduction rate is about 15-50%.
- 7. The method of claim 1 wherein the material constituting the dialysis membrane is selected from the group consisting of polymethylmethacrylate, polyacrylonitrile, cellulose, cellulose acetate, polysulfone, polyvinyl alcohol and a copolymer of vinyl alcohol and ethylene.
- 8. The method of claim 7, wherein the material constituting the dialysis membrane is polymethylmethacrylate.
- 9. The method of claim 7, wherein the material constituting the dialysis membrane is cellulose acetate.
Priority Claims (2)
Number |
Date |
Country |
Kind |
61-136125 |
Jun 1986 |
JPX |
|
61-151679 |
Jun 1986 |
JPX |
|
Parent Case Info
This is a division of application Ser. No. 059,548 filed June 8, 1987, now Pat. No. 4,834,882.
US Referenced Citations (2)
Foreign Referenced Citations (1)
Number |
Date |
Country |
57-56039 |
Apr 1982 |
JPX |
Non-Patent Literature Citations (1)
Entry |
EP-A-0012630, published 06/25/80, Masahiro et al. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
59548 |
Jun 1987 |
|