Claims
- 1. A compound of formula (I) Wherein: A1 and A2 are independently Z—(CH2)k—(NR′)m—; Z is pyridyl, and wherein the ring is substituted or unsubstituted by one or two C1-4alkyl, F, Cl, Br, I, C1-4 alkoxy, (CH2)mR4, oxo, oxime, O—C1-4alkyloxime, hydroxy, N(R3)2, acylamino or aminoacyl groups; R′ and R″ are independently hydrogen, C1-4alkylC(O)R4, C1-4alkyl or R′ and R″ are benzyl which is optionally substituted by one or two C1-4alkyl, C1-4alkoxy, F, Cl, I, Br, OH, or N(R3)2; k is independently an integer from 0 to 4; m is independently zero or one; Q is bicyclo[3.3.0]octanyl, xyleyl, benzophenonyl or 1,2,3,4-tetrahydronapthalyl; all of which are unsubstituted or substituted by one or more C1-4alkyl, C1-4alkoxy, halogen, mono or di C1-4alkylamino, (C1-4alkyl)2—NC(O)—, —(CH2)n—R2, —(CH2)n—R3, —(CH2)n—COR2 or —(CH2)n—COR3; R2 is independently —OR3, —NR32, —SR3; R3 is independently hydrogen, C1-4alkyl or benzyl; R4 is independently —OR3, —N(R3)2, —SR3; an n is independently an integer from 0 to 4; or a pharmaceutically acceptable salt thereof.
- 2. A compound according to claim 1 chosen from the group consisting of:1,7-bis(picolinoylamino)-1,2,3,4-tetrahydronaphthalene; N,N′-bis(picolinoyl)-3,7-diaminobicyclo[3.3.0.]octane; N,N′-bis(picolinoyl)-1,3-xylylenediamine; N,N′-bis(picolinoyl)-4,4′-diaminobenzophenone; N,N′-bis(picolinoyl)-1,2-phenylenediamine; or N,N′-bis(picolinoyl)-1,3-phenylenediamine.
- 3. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier.
- 4. A method of stimulating myelopoiesis in an animal in need thereof by administering a compound of claim 1.
- 5. A method of preventing or treating viral, fungal and bacterial infections which comprises administering to a subject in need thereof, an effective amount of a compound of claim 1.
- 6. A method of preventing or treating sepsis which comprises administering to an animal in need thereof, an effective amount of a compound of claim 1.
Parent Case Info
This application is a 371 of PCT/US 96/18248 filed Nov. 12, 1996, and also claims the benefit of U.S. Provisional No. 60/006,456 filed Nov. 13, 1995.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US96/18248 |
|
WO |
00 |
4/1/1999 |
4/1/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/17958 |
5/22/1997 |
WO |
A |
US Referenced Citations (4)
Non-Patent Literature Citations (1)
Entry |
Witkowski et al., “Structure-activity relationships of antiviral bis-basic fluorenone base-pair analog”, Chemical Abstracts, 92(7), p. 21 (1980) XP002088883. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/006456 |
Nov 1995 |
US |