Claims
- 1. An isolated mutant hepatitis B virus, wherein the virus has a modified "a" determinant comprising an insertion of the amino acids Ash and Thr between positions 122 and 123 of the HBsAg sequence.
- 2. A tissue culture grown cell infected with the mutant virus of claim 1.
- 3. An immunogenic composition comprising the virus of claim 1, wherein the virus is inactivated.
Parent Case Info
This is a division of U.S. patent application Ser. No. 08/059,031 filed on May 7, 1993.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5279944 |
Fabrizi et al. |
Jan 1994 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0511855 |
Nov 1992 |
EPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
59031 |
May 1993 |
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