Herbicidal mixture containing a 3-heterocyclyl-substituted benzoyl derivative

Information

  • Patent Grant
  • 6479437
  • Patent Number
    6,479,437
  • Date Filed
    Tuesday, December 5, 2000
    23 years ago
  • Date Issued
    Tuesday, November 12, 2002
    21 years ago
Abstract
A herbicidal mixture comprisinga) a herbicidally active amount of a 3-heterocyclyl-substituted benzoyl derivative of the formula I  in which the variables have the following meanings:R1,R2 are hydrogen, halogen, C1-C6-alkyl, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy;R3 is hydrogen, halogen, C1-C6-alkyl;X is a heterocycle from amongst the group consisting of isoxazolyl, 4,5-dihydroisoxazolyl and thiazolyl, it being possible for the heterocycle to be optionally monosubstituted or polysubstituted by halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-alkylthio;R5 is hydrogen or C1-C6-alkyl,R6 is C1-C6-alkyl,or their environmentally compatible salts;b) a nitrogenous fertilizer in a synergistically effective amount andc) an adjuvant in a synergistically effective amount.
Description




This application is a 371 of PCT/EP99/03676 filed May 27, 1999.




The present invention relates to a synergistically acting herbicidal mixture of a 3-heterocyclyl-substituted benzoyl derivative, a nitrogenous fertilizer and an adjuvant.




3-Heterocyclyl-substituted benzoyl derivatives are known and are described, for example, in WO 96/26206, WO 97/41116, WO 97/41117 and WO 97/41118.




Herbicidal compositions of substituted cyclohexanediones and nitrogen fertilizers are disclosed in EP-B-0584 227.




It is an object of the present invention to provide a herbicidal mixture which comprises 3-heterocyclyl-substituted benzoyl derivatives and whose herbicidal action exceeds the action of the pure active ingredient.




We have found that this object is achieved by a herbicidal mixture which comprises




a) a herbicidally active amount of a 3-heterocyclyl-substituted benzoyl derivative of the formula I











 in which the variables have the following meanings:




R


1


,R


2


are hydrogen, halogen, C


1


-C


6


-alkyl, C


1


-C


6


-alkylthio, C


1


-C


6


-alkylsulfinyl, C


1


-C


6


-alkylsulfonyl, C


1


-C


6


-haloalkyl, C


1


-C


6


-alkoxy, C


1


-C


6


-haloalkoxy;




R


3


is hydrogen, halogen, C


1


-C


6


-alkyl;




X is a heterocycle from amongst the group consisting of isoxazolyl, 4,5-dihydroisoxazolyl and thiazolyl, it being possible for the heterocycle to be optionally monosubstituted or polysubstituted by halogen, C


1


-C


6


-alkyl, C


1


-C


4


-alkoxy, C


1


-C


4


-haloalkyl, C


1


-C


4


-haloalkoxy, C


1


-C


4


-alkylthio;




R


4


is a pyrazole of the formula II











 which is linked in the 4-position and where




R


5


is hydrogen or C


1


-C


6


-alkyl,




R


6


is C


1


-C


6


-alkyl or their environmentally compatible salts;




b) a nitrogenous fertilizer in a synergistically effective amount and




c) an adjuvant in a synergistically effective amount.




The herbicidal mixture according to the invention exhibits a synergistic effect and is selective for those crop plants which also tolerate the individual compounds themselves.




3-Heterocyclyl-substituted benzoyl derivatives of the formula Ib which are especially preferred with a view to the synergistic herbicidal action are those in which











R


1


, R


2


are chlorine, methyl, ethyl, SCH


3


, SOCH


3


, SO


2


CH


3


;




R


3


is hydrogen and methyl;




R


5


is hydrogen, methyl, trifluoromethyl;




R


6


is methyl, ethyl, isopropyl;




X is a heterocycle from amongst the group: isoxazolyl, 4,5-dihydroisoxazolyl and thiazolyl, it being possible for the heterocycle to be optionally monosubstituted or polysubstituted by halogen, C


1


-C


6


-alkyl, C


1


-C


4


-alkoxy, C


1


-C


4


-haloalkyl, C


1


-C


4


-haloalkoxy, C


1


-C


4


-alkylthio,




or their environmentally compatible salts.




Preferred compounds of the formula Ib are compiled in the table which follows:





















No




R


1






R


2






R


3






R


5






R


6






X











 1




Cl




SO


2


CH


3






H




CH


3






CH


3






2-thiazolyl






 2




Cl




SO


2


CH


3






H




H




CH


3






2-thiazolyl






 3




Cl




SO


2


CH


3






H




CH


3






CH


3






4,5-dihydroisoxazol-3-yl






 4




Cl




Cl




H




CH


3






CH


3






4,5-dihydroisoxazol-3-yl






 5




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydroisoxazol-3-yl






 6




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-methylisoxa-












zol-3-yl






 7




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5,5-dimethyl-












isoxazol-3-yl






 8




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-ethyl-












isoxazol-3-yl






 9




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5,5-diethyl-












isoxazol-3-yl






10




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-chloro-












methylisoxazol-3-yl






11




Cl




SCH


3






H




H




CH


3






4,5-dihydroisoxazol-3-yl






12




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-ethoxy-












isoxazol-3-yl






13




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-methoxy-












isoxazol-3-yl






14




CH


3






SO


2


CH


3






H




H




CH


3






4,5-dihydroisoxazol-3-yl






15




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-4,5-dimethyl-












isoxazol-3-yl






16




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-thioethyl-












isoxazol-3-yl






17




Cl




SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-trifluoro-












methylisoxazol-3-yl






18




SCH


3






SCH


3






H




H




CH


3






4,5-dihydroisoxazol-3-yl






19




Cl




SO


2


CH


3






H




H




C


2


H


5






2-thiazolyl






20




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydroisoxazol-3-yl






21




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5-methyl-












isoxazol-3-yl






22




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5,5-dimethyl-












isoxazol-3-yl






23




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5-ethyl-












isoxazol-3-yl






24




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5,5-diethyl-












isoxazol-3-yl






25




Cl




SCH


3






H




H




C


2


H


5






4,5-dihydroisoxazol-3-yl






26




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5-chloro-












methylisoxazol-3-yl






27




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5-ethoxy-












isoxazol-3-yl






28




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-4,5-dimethyl-












isoxazol-3-yl






29




CH


3






SO


2


CH


3






H




H




C


2


H


5






4,5-dihydroisoxazol-3-yl






30




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5-thioethyl-












isoxazol-3-yl






31




Cl




SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5-trifluoro-












methylisoxazol-3-yl






32




SCH


3






SCH


3






H




H




C


2


H


5






4,5-dihydroisoxazol-3-yl






33




Cl




SO


2


CH


3






H




H




i-C


4


H


9






4,5-dihydroisoxazol-3-yl






34




Cl




SO


2


CH


3






H




H




CH


3






3-methylisoxazol-5-yl






35




Cl




SO


2


CH


3






H




H




C


2


H


5






3-methylisoxazol-5-yl






36




CH


3






SO


2


CH


3






H




H




C


2


H


5






3-methylisoxazol-5-yl






37




CH


3






SO


2


CH


3






H




CH


3






CH


3






4,5-dihydroisoxazol-3-yl






38




CH


3






Cl




H




CH


3






CH


3






4,5-dihydroisoxazol-3-yl






39




CH


3






SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-methyl-












isoxazol-3-yl






40




CH


3






SO


2


CH


3






H




H




CH


3






4,5-dihydro-5,5-dimethyl-












isoxazol-3-yl






41




CH


3






SO


2


CH


3






H




H




CH


3






4,5-dihydro-5-ethyl-












isoxazol-3-yl






42




CH


3






SO


2


CH


3






H




H




CH


3






4,5-dihydro-5,5-ethyl-












isoxazol-3-yl






43




CH


3






SO


2


CH


3






H




H




CH


3






4,5-dihydroisoxazol-3-yl






44




CH


3






SO


2


CH


3






H




H




CH


3






4,5-dihydro-4,5-dimethyl-












isoxazol-3-yl






45




CH


3






Cl




H




H




C


2


H


5






4,5-dihydroisoxazol-3-yl






46




CH


3






SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5-methyl-












isoxazol-3-yl






47




CH


3






SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5,5-dimethyl-












isoxazol-3-yl






48




CH


3






SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-5-ethyl-












isoxazol-3-yl






49




CH


3






SO


2


CH


3






H




H




C


2


H


5






4,5-dihydro-4,5-dimethyl-












isoxazol-3-yl






50




CH


3






SO


2


CH


3






H




H




i-C


4


H


9






4,5-dihydroisoxazol-3-yl














Very especially preferred are the compounds




4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole,




4-[2-methyl-3-(4,5-dihydroisoxazol-3-yl) -4-methylsulfonylbenzoyl ]-1-methyl-5-hydroxy-1H-pyrazole,




4-[2-chloro-3-(3-methylisoxazol-5-yl)-4-methylsulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole,




or their environmentally compatible salts.




Suitable environmentally compatible salts are salts of, for example, alkali metals, alkaline earth metals, ammonia or amines.




Suitable nitrogenous fertilizers b) are ammonia and ammonium salts, urea, thiourea and mixtures of these.




Examples of suitable fertilizers are aqueous ammonia solution, ammonium nitrate, ammonium sulfate, ammonium hydrogen sulfate, ammonium chloride, ammonium acetate, ammonium formate, ammonium oxalate, ammonium carbonate, ammonium hydrogen carbonate, ammonium nitrate, ammonium thiosulfate, ammonium phosphate, ammonium hydrogen diphosphate, ammonium dihydrogen monophosphate, ammonium sodium hydrogen phosphate, ammonium thiocyanate, urea and thiourea, and mixtures of these, and also ammonium nitrate/urea solutions (UAN or AHL solutions).




Preferred nitrogenous fertilizers are urea, ammonium nitrate, ammonium nitrate/urea solutions, ammonium sulfate, ammonium phosphate, ammonium hydrogen diphosphate, ammonium dihydrogen monophosphate and ammonium sodium hydrogen phosphate.




Very especially preferred are urea, ammonium nitrate and ammonium nitrate/urea solutions. The ammonium nitrate/urea solutions preferably have a total nitrogen content of 28-33% (w/w) and are commercially available from BASF, for example under the brand name Ensol® 28.




Suitable adjuvants c) are vegetable oils which can be partially hydrogenated and hydrogenated, modified vegetable oils, mineral oils, alcohol alkoxylates, alcohol ethoxylates, alkylated EO/PO block copolymers, alkylphenol ethoxylates, polyols, EO/PO block copolymers, organosilicon compounds, alkylglycosides, alkyl polyglycosides, alkyl sulfates, sulfated alcohol alkoxylates, alkylarylsulfonates, alkylsulfonates, dialkylsulfosuccinates, phosphated alcohol alkoxylates, fatty amine alkoxylates, esters, carboxylates, ester ethoxylates, dialkyl adipates, dicarboxylic acid derivatives, such as alkenylsuccinic anhydride condensates with polyalkylene oxides or polyhydroxyamines; dialkyl phthalates, ethoxylated sorbitan esters of natural fatty acids and ethoxylated glycerides of natural fatty acids.




Preferred adjuvants are alcohol alkoxylates, such as alkyl ethers of EO/PO copolymers, for example Plurafac® (BASF AG), Synperionic® LF (ICI), alcohol ethoxylates, the alcohol being a C


8


-C


18


-alcohol of synthetic or natural origin which may be either linear or branched. The ethoxylate moiety contains on average 3-20 moles of ethylene oxide, depending on the alcohol used. Products used are, for example, Lutensol® ON, TO, AO and A by BASF, alkylarylsulfonates, such as nonylphenyl ethoxylates with 5-15 moles of EO, polyols such as polyethylene glycol or polypropylene glycol, EO/PO block copolymers such as, for example, Pluronic® PE (BASF AG) or Synperionic® PE (ICI), organosilicon compounds, alkyl polyglycosides, such as, for example, Agrimul® (Henkel KGA), AG 6202 (Akzo-Nobel), Atplus® 450 (ICI) or Lutensol® GD 70 (BASF AG), fatty amine alkoxylates, such as, for example, Ethomeen® and Armobleem® by Akzo Nobel, esters of natural and synthetic fatty acids, such as, for example, methyl oleates or methyl cocoates, dialkyl adipates, ethoxylated sorbitan esters of natural fatty acids, such as, for example, Tween® by ICI Surfactants (Tween® 20, Tween® 85, Tween® 80), ethoxylated glycerides of natural fatty acids, such as, for example, Glycerox® by Croda.




Other examples are found in:




McCutcheon's; Emulsifiers and Detergents, Volume 1: Emulsifiers and Detergents 1994 North American Edition;




McCutcheon's Division, Glen Rock N.J., USA,




McCutcheon's; Emulsifiers and Detergents, Volume 2: Emulsifiers and Detergents 1994 International Edition;




McCutcheon Division, Glen Rock N.J., USA,




Surfactants in Europe;




A Directory of surface active agents available in Europe 2nd Ed. 1989;




Terg Data, Darlington, England,




Ash, Michael;




Handbook of cosmetic and personal care additives 1994;




Gower Publishing Ltd, Aldershot, England




Ash, Michael;




Handbook of industrial Surfactants 1993;




Gower Publishing Ltd. Aldershot, England.




The herbicidal mixture according to the invention comprises the following amounts of the components a) to c):




0.5 to 90% by weight of the 3-heterocyclyl-substituted benzoyl derivative a);




5 to 94.5% by weight of the nitrogenous fertilizer b);




5 to 50% by weight of the adjuvant c).




Preferred weight ratios are:




0.5 to 50% by weight of the 3-heterocyclyl-substituted benzoyl derivative a);




5 to 90% by weight of the nitrogenous fertilizer b);




5 to 50% by weight of the adjuvant c).




The components together add up to 100% by weight.




The individual components a) to c) of the herbicidal mixture according to the invention can be formulated and packaged jointly or individually. Furthermore, it is possible to formulate and pack the components a) together with b), or a) together with c).




The practitioner uses the herbicidal mixture or its individual components for use in the spray tank.




For this purpose, the herbicidal mixture is diluted with water, adding, if appropriate, other auxiliaries and additives. However, the practitioner may also mix the individual components a) to c) of the herbicidal mixture according to the invention himself in the spray tank and, if appropriate, add further auxiliaries and additives (tank mix method).




For the tank mix method, the components a) to c) are mixed in the spray tank and made up to the desired use concentration with water.




The following adjuvants have proved advantageous for the tank mix method:




mineral oils, liquid paraffins, vegetable oils, hydrogenated or methylated vegetable oils, such as, for example, soya oil, rapeseed oil, sunflower oil, esters and salts of natural carboxylic acids, such as, for example, methyl oleate, methylated seed oils, nonionic surfactants, such as ethoxylated alcohols, ethoxylated phenols, fatty amine ethoxylates, and mixtures of these.




Further auxiliaries and additives may be added for better processing. The following components have proved themselves as auxiliaries and additives:




solvents, antifoams, buffers, thickeners, spreading agents, compatibility-enhancing agents.




Examples and brands of adjuvants, auxiliaries and additives are described in Farm Chemicals Handbook 1997; Meister Publishing 1997 p. C10 “adjuvant” or 1998 Weed Control Manual p. 86.




The mixture according to the invention is suitable as herbicide. The herbicidal mixture effects very good control of vegetation on non-crop areas, especially at high rates of application. In crops such as wheat, rice, maize, soybeans and cotton it acts against broad-leaved weeds and grass weeds without damaging the crop plants substantially. This effect is observed especially at low rates of application.




Depending on the application method in question the herbicidal mixture can additionally be employed in a further number of crop plants for eliminating undesirable plants. Examples of suitable crops are the following:






Allium cepa, Ananas comosus, Arachis hypogaea, Asparagus officinalis, Beta vulgaris


spec.


altissima, Beta vulgaris


spec.


rapa, Brassica napus


var.


napus, Brassica napus


var.


napobrassica, Brassica rapa


var.


silvestris, Camellia sinensis, Carthamus tinctorius, Carya illinoinensis, Citrus limon, Citrus sinensis, Coffea arabica


(


Coffea canephora, Coffea liberica


),


Cucumis sativus, Cynodon dactylon, Daucus carota, Elaeis guineensis, Fragaria vesca, Glycine max, Gossypium hirsutum


, (


Gossypium arboreum, Gossypium herbaceum, Gossypium vitifolium


),


Helianthus annuus, Hevea brasiliensis, Hordeum vulgare, Humulus lupulus, Ipomoea batatas, Juglans regia, Lens culinaris, Linum usitatissimum, Lycopersicon lycopersicum


, Malus spec.,


Manihot esculenta, Medicago sativa


, Musa spec.,


Nicotiana tabacum


(


N.rustica


),


Olea europaea, Oryza sativa, Phaseolus lunatus, Phaseolus vulgaris, Picea abies


, Pinus spec.,


Pisum sativum, Prunus avium, Prunus persica, Pyrus communis, Ribes sylvestre, Ricinus communis, Saccharum officinarum, Secale cereale, Solanum tuberosum, Sorghum bicolor


(


s. vulgare


),


Theobroma cacao, Trifolium pratense, Triticum aestivum, Triticum durum, Vicia faba, Vitis vinifera


and


Zea mays.






Moreover, the herbicidal mixture can also be used in crops which tolerate the action of herbicides due to breeding including genetic engineering methods.




The herbicidal mixture can be applied pre- or post-emergence. If the herbicidal mixture is less well tolerated by certain crop plants, application techniques may be used in which the herbidical mixture is sprayed, with the aid of the spray apparatus, in such a way that it comes into little contact, if any, with the leaves of the sensitive crop plants while reaching the leaves of undesirable plants which grow underneath, or the bare soil (post-directed, lay-by).




The herbicidal mixture can be employed, for example, in the form of directly sprayable aqueous solutions, powders, suspensions, also highly-concentrated aqueous, oily or other suspensions or dispersions, emulsions, oil dispersions, pastes, dusts, materials for spreading or granules, by means of spraying, atomizing, dusting, spreading or pouring. The use forms depend on the intended purposes; in any case, they should guarantee the finest possible distribution of the herbicidal mixture according to the invention.




Suitable inert auxiliaries are essentially: mineral oil fractions of medium to high boiling point such as kerosene and diesel oil, furthermore coal tar oils and oils of vegetable or animal origin, aliphatic, cyclic and aromatic hydrocarbons, e.g. paraffin, tetrahydronaphthalene, alkylated naphthalenes and their derivatives, alkylated benzenes and their derivatives, alcohols such as methanol, ethanol, propanol, butanol and cyclohexanol, ketones such as cyclohexanone, or strongly polar solvents, e.g. amines such as N-methylpyrrolidone and water.




Aqueous use forms can be prepared from emulsion concentrates, suspensions, pastes, wettable powders or water-dispersible granules by adding water. To prepare emulsions, pastes or oil dispersions, the herbicidal mixture, as such or dissolved in an oil or solvent, can be homogenized in water by means of wetting agent, tackifier, dispersant or emulsifier. However, it is also possible to prepare concentrates composed of active substance, wetting agent, tackifier, dispersant or emulsifier and, if appropriate, solvent or oil, and these concentrates are suitable for dilution with water.




Suitable surfactants are the alkali metal, alkaline earth metal and ammonium salts of aromatic sulfonic acids, e.g. lignosulfonic acid, phenolsulfonic acid, naphthalenesulfonic acid and dibutylnaphthalenesulfonic acid, and of fatty acids, of alkyl- and alkylarylsulfonates, of alkyl sulfates, lauryl ether sulfates and fatty alcohol sulfates, and salts of sulfated hexa-, hepta- and octadecanols, and of fatty alcohol glycol ether, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene, or of the naphthalenesulfonic acids, with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxylated isooctyl-, octyl- or nonylphenol, alkylphenyl and tributylphenyl polyglycol ethers, alkylaryl polyether alcohols, isotridecyl alcohol, fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers or polyoxypropylene alkyl ethers, lauryl alcohol polyglycol ether acetate, sorbitol esters, lignin-sulfite waste liquors or methylcellulose.




Powders, materials for spreading and dusts can be prepared by mixing or concomitantly grinding the herbicidal mixture with a solid carrier.




Granules, e.g. coated granules, impregnated granules and homogeneous granules, can be prepared by binding the active ingredients to solid carriers. Solid carriers are mineral earths such as silicas, silica gels, silicates, talc, kaolin, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas and products of vegetable origin such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powder or other solid carriers.




The concentrations of the herbicidal mixture in the ready-to-use products can be varied within wide ranges. In general, the formulations comprise approximately from 0.001 to 98% by weight, preferably 0.01 to 95% by weight, of the herbicidal mixture. The components of the mixture are employed in a purity of from 90% to 100%, preferably 95% to 100% (according to NMR spectrum).











The herbicidal mixture according to the invention can be formulated, for example, as follows:




A) Concentrates for Preparing the Mixture According to the Invention




1) Suspension Concentrate




108 g of 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methyl-sulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole (technical grade 92%), 20 g/l of Wettol® D1 by BASF, 30 g of Pluronic® PE 10500 by BASF AG, 3 g of Kelzan®, 1.4 g of Kathon® MK, 70 g of 1,2-propylene glycol and 5 g of silicone emulsion by Wacker were made up to 1 liter with water and the mixture was subsequently ground in a ball mill to a particle size of 60% <2 microns.




2) Suspension Concentrate




503 g of 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methyl-sulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole (technical grade 99%), 20 g/l of Wettol® DI by BASF, 30 g of Pluronic® PE 10500 by BASF AG, 3 g of Kelzan®, 1.4 g of Kathon® MK, 70 g of 1,2-propylene glycol and 5 g of silicone emulsion by Wacker were made up to 1 liter with water and the mixture was subsequently ground in a ball mill to a particle size of 60%<2 microns.




3) Water-soluble Concentrate of Component a)




100 g of the active ingredient 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole (99% technical grade) are dispersed in approx. 800 ml of water. The active ingredient is neutralized with dilute potassium hydroxide solution (KOH), and the formulation brought to pH 8.5. The product is then made up to 1 liter.




B) Herbicidal Mixtures According to the Invention




4) Suspension Concentrate




100 ml of the concentrate prepared as described under 2) were mixed with 220 ml of water and 360 ml of ammonium nitrate/urea solution (ENSOL® 28, BASF AG). Using a high-speed stirrer, a solution of 14 g of a calcium dodecylbenzenesulfonate (Wettol® EM 1, BASF AG), 14 g of a castor oil ethoxylate with 40 moles of EO (Wettol® EM 31, BASF AG) and 250 ml of a dioctyl adipate (Plastomoll® DOA, BASF AG) were incorporated into this mixture to give an emulsion. This gave a stable suspension of the 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-benzoyl]-1-methyl-5-hydroxy-1H-pyrazole with an active ingredient content of 50 g/l.




5) Suspension Concentrate




100 ml of the concentrate prepared as described under 2) were mixed with 220 ml of water and 360 ml of ammonium nitrate/urea solution (ENSOL® 28, BASF AG). Using a high-speed stirrer, 250 ml of methyl oleate were incorporated into this mixture to give an emulsion. This gave a stable suspension of the 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-benzoyl]-1-methyl-5-hydroxy-1H-pyrazole with an active ingredient content of 50 g/l.




6) Water-dispersible Granules




50 g of the active ingredient 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole (99%, technical grade), 50 g of naphthalenesulfonic acid/formaldehyde condensate, 10 g of sodium ligninsulfonate and 600 g of ammonium sulfate are mixed intimately and ground in an air-jet mill. In a mixer, the resulting powder is mixed with 31 g of ethylhexyl glucoside (65% strength aqueous solution). The mixture is extruded in an extruder (DGL-1 by Fitzpatrick, Belgium, aperture diameter 0.8 mm). If appropriate, more liquid is added to achieve extrudability. The granules are dried, and water-dispersible granules with an active ingredient content of 5% are obtained.




7) Water-soluble Concentrate




50 g of the active ingredient 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole (99%, technical grade) are dispersed in 200 ml of water and the mixture is neutralized with dilute potassium hydroxide solution (KOH). This mixture is treated with 360 g of ammonium nitrate/urea solution (ENSOL® 28, BASF AG) and 250 g of Lutensol® ON 80 (BASF AG). The product is brought to pH 8.5 using KOH and made up to 1 liter with water.




8) Water-soluble Concentrate




100 g of the active ingredient 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole (99% technical grade) are dispersed in approx. 300 ml of water. The active ingredient is neutralized with dilute potassium hydroxide solution (KOH) and the formulation is brought to pH 8.5. 500 g of AG 6202 are incorporated into the formulation by stirring. After homogenization, the pH is rechecked and, if necessary, corrected. The product is then made up to 1 liter.




To widen the spectrum of action and to achieve synergistic effects, the herbicidal mixture can be mixed and applied jointly with a large number of representatives of other groups of herbicidally or growth-regulatory active ingredients. Suitable components in mixtures are, for example, 1,2,4-thiadiazoles, 1,3,4-thiadiazoles, amides, aminophosphoric acid and its derivatives, aminotriazoles, anilides, (het)-aryloxyalkanoic acids and their derivatives, benzoic acid and its derivatives, benzothiadiazinones, 2-aroyl-1,3-cyclohexandiones, hetaryl aryl ketones, benzylisoxazolidinones, meta-CF


3


-phenyl derivates, carbamates, quinolinecarboxylic acid and its derivatives, dihydrobenzofurans, dihydrofuran-3-ones, dinitroanilines, dinitrophenols, diphenyl ethers, dipyridyls, halocarboxylic acids and their derivatives, ureas, 3-phenyluracils, imidazoles, imidazolinones, N-phenyl-3,4,5,6-tetrahydrophthalimides, oxadiazoles, oxiranes, phenols, aryloxy- or heteroaryloxyphenoxypropionic esters, phenylacetic acid and its derivatives, phenylpropionic acid and its derivatives, pyrazoles, phenylpyrazoles, pyridazines, pyridinecarboxylic acid and its derivatives, pyrimidyl ethers, sulfonylureas, triazines, triazinones, triazolinones, triazolecarboxamides and uracils.




Moreover, it may be advantageous to apply the herbicidal mixture, alone or in combination with other herbicides, in the form of a mixture with additional other crop protection agents, for example with pesticides or agents for controlling phytophathogenic fungi or bacteria. Also of interest is the miscibility with mineral salt solutions which are employed for treating nutritional and trace element deficiencies.




The application rate of herbicidal mixture amounts to 0.001 to 1.0, preferably 0.01 to 0.5, kg/ha active substance (a. s.), based on the pure components of the herbicidal mixture, depending on the intended aim, the season, the target plants and the growth stage.




Use example




The herbicidal action of the compositions according to the invention was demonstrated by greenhouse experiments:




The culture containers used were plastic pots containing loamy sand with approximately 3.0% of humus as substrate. The seeds of the test plants were sown separately for each species.




For the pre-emergence treatment, the herbicidal mixture, suspended or emulsified in water, was applied directly after sowing by means of finely distributing nozzles. The containers were irrigated gently to promote germination and growth and subsequently covered with translucent plastic hoods until the plants had rooted. This cover caused uniform germination of the test plants unless this was adversely affected by the herbicidal mixture.




For the post-emergence treatment, the test plants were grown to a plant height of from 3 to 15 cm, depending on the plant habit, and only then treated with the herbicidal mixture which had been suspended or emulsified in water. To this end, the test plants were either sown directly and grown in the same containers, or they were first grown separately as seedlings and transplanted into the test containers a few days prior to treatment.




Depending on the species, the plants were kept at 10-25° C. or 20-35° C. The test period extended over 2 to 4 weeks. During this time, the plants were tended, and their response to the individual treatments was evaluated.




Evaluation was carried out using a scale of from 0 to 100. 100 means no emergence of the plants, or complete destruction of at least the aerial parts, and 0 means no damage or normal course of growth.




The plants used in the greenhouse experiments belonged to the following species:




















Abbreviation




Scientific name




Common name













ABUTH






Abutilon theophrasti






velvetleaf







CHEAL






Chenopodium album






lambsquarters (goosefoot)







ECHCG






Echinochloa crus-galli






barnyardgrass







POLPE






Polygonum persicaria






lady's thumb







SETVI






Setaria viridis






green foxtail







ZEAMX






Zea mays






corn















Example 1



















TABLE 1











Selective herbicidal activity post-emergence in the greenhouse
















Active




Rate of a.s. in




Phytotoxicity

















ingredient




kg/ha




ZEAMX




CHEAL











EX. 1




0.0078




0




20







EX. 1




0.0078




0




90







+




+







Pluronic ® PE 6400




0.25 







EX. 1




0.0078




0




95







+




+







Pluronic ® PE 6400




0.25 







+




+







ENSOL ® 28




0.375 























TABLE 2











Selective herbicidal activity post-emergence in the greenhouse
















Active




Rate of a.s. in




Phytotoxicity

















ingredient




kg/ha




ZEAMX




CHEAL











EX. 1




0.0625




0




50







EX. 1




0.0625




0




75







+




+







Pluronic ® PE 6800




0.25 







EX. 1




0.0625




0




80







+




+







Pluronic ® PE 6800




0.25 







+




+







ENSOL ® 28




0.375 























TABLE 3











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




ECHCG









EX. 1




0.0625




50






EX. 1




0.0625




75






+




+






Agrimul ® PG 2067




0.25 






EX. 1




0.0625




80






+




+






Agrimul ® PG 2067




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 4











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




ABUTH









EX. 1




0.0156




20






EX. 1




0.0156




70






+




+






Agrimul ® PG 2067




0.25 






EX. 1




0.0156




80






+




+






Agrimul ® PG 2067




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 5











Selective herbicidal activity post-emergence in the greenhouse
















Active




Rate of a.s. in




Phytotoxicity

















ingredient




kg/ha




ECHCG




ABUTH











EX. 1




0.0312




030




75







EX. 1




0.0312




 40




80







+




+







Agrimul ® PG 600




0.25 







EX. 1




0.0312




 70




85







+




+







Agrimul ® PG 600




0.25 







+




+







ENSOL ® 28




0.375 























TABLE 6











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




CHEAL









EX. 1




0.0078




20






EX. 1




0.0078




70






+




+






Agrimul ® PG 600




0.25 






EX. 1




0.0078




98






+




+






Agrimul ® PG 600




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 7











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




CHEAL









EX. 1




0.0156




20






EX. 1




0.0156




90






+




+






Lutensol ® GD 70




0.25 






EX. 1




0.0156




95






+




+






Lutensol ® PG 600




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 8











Selective herbicidal activity post-emergence in the greenhouse
















Active




Rate of a.s. in




Phytotoxicity

















ingredient




kg/ha




ZEAMX




ECHCG











EX. 1




0.0625




0




50







EX. 1




0.0625




0




60







+




+







AG ® 6202




0.25 







EX. 1




0.0625




0




80







+




+







AG ® 6202




0.25 







+




+







ENSOL ® 28




0.375 























TABLE 9











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




ECHCG









EX. 1




0.0625




50






EX. 1




0.0625




90






+




+






Lutensol ® ON 30




0.25 






EX. 1




0.0625




100 






+




+






Lutensol ® ON 30




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 10











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




CHEAL









EX. 1




0.0078




20






EX. 1




0.0078




80






+




+






Lutensol ® ON 80




0.25 






EX. 1




0.0078




98






+




+






Lutensol ® ON 80




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 11











Selective herbicidal activity post-emergence in the greenhouse














Active




Rate of a.s. in




Phytotoxicity















ingredient




kg/ha




SETVI




CHEAL









EX. 1




0.0078




30




20






EX. 1




0.0078




40




60






+




+






Lutensol ® ON 110




0.25 






EX. 1




0.0078




95




95






+




+






Lutensol ® ON 110




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 12











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




CHEAL









EX. 1




0.0156




20






EX. 1




0.0156




50






+




+






Lutensol ® TO 8




0.25 






EX. 1




0.0156




80






+




+






Lutensol ® TO 8




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 13











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




CHEAL









EX. 1




0.0156




20






EX. 1




0.0156




60






+




+






Pluriol ® E 600




0.25 






EX. 1




0.0156




98






+




+






Pluriol ® E 600




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 14











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




CHEAL









EX. 1




0.0156




20






EX. 1




0.0156




90






+




+






Pluriol ® E 4000




0.25 






EX. 1




0.0156




98






+




+






Pluriol ® E 4000




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 15











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




ECHCG









EX. 1




0.0625




50






EX. 1




0.0625




85






+




+






Glycerox ® L 8




0.25 






EX. 1




0.0625




90






+




+






Glycerox ® L 8




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 16











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




ABUTH









EX. 1




0.0156




20






EX. 1




0.0156




70






+




+






Glycerox ® L 8




0.25 






EX. 1




0.0156




80






+




+






Glycerox ® L 8




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 17











Selective herbicidal activity post-emergence in the greenhouse
















Active




Rate of a.s. in




Phytotoxicity

















ingredient




kg/ha




SETVI




POLPE











EX. 1




0.0078




30




20







EX. 1




0.0078




20




40







+




+







Glycerox ® HE




0.25 







EX. 1




0.0078




95




95







+




+







Glycerox ® HE




0.25 







+




+







ENSOL ® 28




0.375 























TABLE 18











Selective herbicidal activity post-emergence in the greenhouse













Active




Rate of a.s. in




Phytotoxicity






ingredient




kg/ha




POLPE









EX. 1




0.0078




70






EX. 1




0.0078




80






+




+






Plastomoll ® DOA




0.25 






EX. 1




0.0078




95






+




+






Plastomoll ® DOA




0.25 






+




+






ENSOL ® 28




0.375 






















TABLE 19











Selective herbicidal activity post-emergence in the greenhouse
















Active




Rate of a.s. in




Phytotoxicity

















ingredient




kg/ha




SETVI




POLPE











EX. 1




0.0078




40




70







EX. 1




0.0078




60




80







+




+







Lutensol ® TO 15




0.25 







EX. 1




0.0078




95




90







+




+







Lutensol ® TO 15




0.25 







+




+







ENSOL ® 28




0.375 























TABLE 20











Selective herbicidal activity post-emergence in the greenhouse
















Active




Rate of a.s. in




Phytotoxicity

















ingredient




kg/ha




ZEAMX




SETVI











EX. 1




0.0078




0




40







EX. 1




0.0078




0




55







+




+







Lutensol ® AT 11




0.25 







EX. 1




0.0078




0




95







+




+







Lutensol ® AT 11




0.25 







+




+







ENSOL ® 28




0.375 























TABLE 21











Selective herbicidal activity post-emergence in the greenhouse
















Active




Rate of a.s. in




Phytotoxicity

















ingredient




kg/ha




SETVI




POLPE











EX. 1




0.0078




40




70







EX. 1




0.0078




45




90







+




+







Lutensol ® AT 25




0.25 







EX. 1




0.0078




90




95







+




+







Lutensol ® AT 25




0.25 







+




+







ENSOL ® 28




0.375 















Legend to the adjuvants employed:















Name

























Pluronic ® PE 6400




BASF AG




EO/PO block copolymer






Pluronic ® PE 6800




BASF AG




EO/PO block copolymer






Agrimul ® PG 2067




Henkel




alkyl glycoside APG






Agrimul ® PG 600




Henkel




alkyl glycoside APG






AG ® 6202




Akzo




alkyl glycoside APG






Lutensol ® GD 70




BASF AG




alkyl glycoside APG






Lutensol ® ON 30




BASF AG




alkyl ethoxylate






Lutensol ® ON 80




BASF AG




alkyl ethoxylate






Lutensol ® ON 110




BASF AG




alkyl ethoxylate






Lutensol ® TO 8




BASF AG




alkyl ethoxylate






Lutensol ® TO 15




BASF AG




alkyl ethoxylate






Lutensol ® AT 11




BASF AG




alkyl ethoxylate






Lutensol ® AT 25




BASF AG




alkyl ethoxylate






Pluriol ® E 600




BASF AG




polyethylene glycol






Pluriol ® E 4000




BASF AG




polyethylene glycol






Plastomoll ® DOA




BASF AG




dioctyl adipate






Glycerox ® L 8




Croda




ethoxylated monoglyceride






Glycerox ® HE




Croda




ethoxylated monoglyceride






ENSOL ® 28




BASF AG




ammonium nitrate/urea solution








(total nitrogen 28%)














The values in Tables 1 to 21 demonstrate clearly the synergistic effect of the herbicidal mixture according to the invention in comparison with the corresponding two-way mixtures and in comparison with the pure active ingredient while simultaneously being highly selective in the crop plant maize.



Claims
  • 1. A herbicidal mixture comprisinga) a herbicidally active amount of a 3-heterocyclyl-substituted benzoyl derivative of the formula I  in which the variables have the following meanings: R1,R2 are hydrogen, halogen, C1-C6-alkyl, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy; R3 is hydrogen, halogen, C1-C6-alkyl; X is a heterocycle from amongst the group consisting of isoxazolyl, 4,5-dihydroisoxazolyl and thiazolyl, it being possible for the heterocycle to be optionally monosubstituted or polysubstituted by halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-alkylthio; R4 is a pyrazole of the formula II  which is linked in the 4-position and where R5 is hydrogen or C1-C6-alkyl, R6 is C1-C6-alkyl, or their environmentally compatible salts;b) a nitrogenous fertilizer in a synergistically effective amount and c) an adjuvant in a synergistically effective amount.
  • 2. A herbicidal mixture as claimed in claim 1, comprising a 3-heterocyclyl-substituted benzoyl derivative of the formula I as claimed in claim 1 where R3 is hydrogen.
  • 3. A herbicidal mixture as claimed in claim 1, comprising a 3-heterocyclyl-substituted benzoyl derivative of the formula I as claimed in claim 1, whereR1,R2 are halogen, C1-C6-alkyl, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl.
  • 4. A herbicidal mixture as claimed in claim 1, comprising a 3-heterocyclyl-substituted benzoyl derivative of the formula I as claimed in claim 1 where X is isoxazolyl and 4,5-dihydroisoxazolyl, each of which can optionally be substituted by C1-C6-alkyl.
  • 5. A herbicidal mixture as claimed in claim 1, comprising a 3-heterocyclyl-substituited benzoyl derivative of the formula I as claimed in claim 1 where X is isoxazol-5-yl, 3-methylisoxazol-5-yl, 4,5-dihydroisoxazol-3-yl, 4,5-dihydro-5-methylisoxazol-3-yl, 4,5-dihydro-5-ethylisoxazol-3-yl, 4,5-dihydro-4,5-dimethylisoxazol-3-yl.
  • 6. A herbicidal mixture as claimed in claim 1, comprising 4-[2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole.
  • 7. A herbicidal mixture as claimed in claim 1, comprising 4-[2-methyl-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoyl]-1-methyl-5-hydroxy-1H-pyrazole.
  • 8. A herbicidal mixture as claimed in claim 1, comprising a nitrogenous fertilizer b) selected from the series consisting of ammonia, ammonium salts, urea, thiourea and mixtures of these.
  • 9. A herbicidal mixture as claimed in claim 1, comprising0.5-90% by weight of the 3-heterocyclyl-substituted benzoyl derivative a); 5-94.5% by weight of the nitrogenous fertilizer b); 5-50% by weight of the adjuvant c).
  • 10. A process for the preparation of a herbicidal mixture as claimed in claim 1, which comprises mixing the components a) to c) of the herbicidal mixture with each other.
  • 11. A method of controlling undesirable vegetation, which comprises mixing a herbicidally active amount of the components a) to c) of the herbicidal mixture as claimed in claim 1 with each other and allowing the mixture to act on the plants or their environment.
Priority Claims (1)
Number Date Country Kind
198 25 588 Jun 1998 DE
PCT Information
Filing Document Filing Date Country Kind
PCT/EP99/03676 WO 00
Publishing Document Publishing Date Country Kind
WO99/63823 12/16/1999 WO A
US Referenced Citations (1)
Number Name Date Kind
5658855 Nalewaja et al. Aug 1997 A
Foreign Referenced Citations (7)
Number Date Country
584 227 Mar 1994 EP
701626 Dec 1979 SU
WO 9219107 Nov 1992 WO
WO 9626206 Aug 1996 WO
WO 9741116 Nov 1997 WO
WO 9741117 Nov 1997 WO
WO 9741118 Nov 1997 WO
Non-Patent Literature Citations (1)
Entry
Klingman et al. Weed Science: Principles and Practices. 2nd ed. NY:John Wiley & Sons. p. 106-107,294. 1982.