TREA

Herbicidal pyridine N-oxide sulfonylureas

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Information

  • Patent Grant
  • 4789465
  • Patent Number
    4,789,465
  • Date Filed
    Monday, August 31, 1987
    37 years ago
  • Date Issued
    Tuesday, December 6, 1988
    36 years ago
Information
Abstract
This invention relates to pyridine N-oxide sulfonylurea herbicides, agriculturally suitable compositions containing them and their method-of-use as preemergent and/or postemergent herbicides or plant growth regulants.
Description

BACKGROUND OF THE INVENTION
EP-A-No. 13,480 discloses herbicidal sulfonamides of the formula ##STR1## wherein R.sub.1 is H, Cl, Br, F, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, NO.sub.2 or CO.sub.2 R.sub.5.
U.S. Pat. No. 4,339,267 discloses herbicidal sulfonamides of the formula ##STR2## wherein R.sub.4 is H, Cl, Br, F, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, NO.sub.2, CO.sub.2 R.sub.6 or SR.sub.13.
U.S. Pat. No. 4,342,587 discloses herbicidal sulfonamides of the formula ##STR3## wherein B is Cl or Br.
U.S. Pat. No. 4,456,469 discloses herbicidal sulfonamides of the formula ##STR4## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.5 -C.sub.6 cycloalkyl, R'OCH.sub.2 CH.sub.2 OCH.sub.2, R'OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2, ##STR5## CF.sub.3, CF.sub.3 CH.sub.2, HGLCCF.sub.2 or HCF.sub.2 ; and Z is H, F, Cl, Br, CH.sub.3, OCH.sub.3 or SCH.sub.3.
U.S. Pat. No. 4,487,626 discloses herbicidal sulfonamides of the formula ##STR6## wherein A is ##STR7## and R.sub.2 is H, F, Cl, Br, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, NO.sub.2, CO.sub.2 R.sub.15, S(O).sub.m R.sub.16, SO.sub.2 NR.sub.18 R.sub.19 or SO.sub.2 N(OCH.sub.3)CH.sub.3.
U.S. Pat. No. 4,421,550 discloses herbicidal sulfonamides of the formula ##STR8## wherein Z is ##STR9## and R.sub.16 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, F, Cl, Br, CF.sub.3, CO.sub.2 R.sub.20, SO.sub.2 NR.sub.10 R.sub.11, SO.sub.2 N(OCH.sub.3)CH.sub.3 or S(O).sub.n R.sub.13.
U.S. Pat. No. 4,496,392 discloses herbicidal sulfonamides of the formula ##STR10## wherein R.sub.3 is Cl, SO.sub.2 CH.sub.3 or SO.sub.2 N(CH.sub.3).sub.2.
EP-A-No. 84,224 discloses herbicidal sulfonamides of the formula ##STR11## wherein A is ##STR12## and R.sub.16 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, F, Cl, Br, CF.sub.3, CO.sub.2 R.sub.9, SO.sub.2 NR.sub.10 R.sub.11, SO.sub.2 N(OCH.sub.3)CH.sub.3 or S(O).sub.n R.sub.13.
EP-A-No. 125,846 discloses herbicidal sulfonamides of the formula ##STR13## wherein J is ##STR14## and R is Cl, SO.sub.2 CH.sub.3, SO.sub.2 N(CH.sub.3).sub.2, OCH.sub.3, NO.sub.2 or N(CH.sub.3).sub.2.
EP-A-No. 155,767 discloses herbicidal sulfonamides of the formula ##STR15## wherein J is ##STR16## and R.sub.5 is H, CH.sub.3, Cl, Br, CO.sub.2 R.sub.15, C(O)NR.sub.16 R.sub.17, SO.sub.2 NR.sub.16 R.sub.17, SO.sub.2 N(OCH.sub.3)CH.sub.3, SO.sub.2 R.sub.18 or NO.sub.2.
EP-A-No. 161,905 discloses herbicidal sulfonamides of the formula ##STR17## wherein R.sub.4 is CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, F, Cl, Br, SO.sub.2 NR.sub.16 R.sub.17, SO.sub.2 N(OCH.sub.3)CH.sub.3, S(O).sub.n R.sub.19, C.sub.3 -C.sub.4 alkenyloxy or C.sub.3 -C.sub.4 alkynyloxy.
EP-A-No. 164,269 discloses herbicidal sulfonamides of the formula ##STR18## wherein R.sub.4 is CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, F, Cl, Br, SO.sub.2 NR.sub.11 R.sub.12, SO.sub.2 N(OCH.sub.3)CH.sub.3 or S(O).sub.n R.sub.13.
EP-A-No. 171,286 discloses herbicidal sulfonamides of the formula ##STR19## wherein R.sub.4 is CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, F, Cl, Br, SO.sub.2 NR.sub.18 R.sub.19, SO.sub.2 N(OCH.sub.3)CH.sub.3, S(O).sub.n R.sub.21, C.sub.3 -C.sub.4 alkenyloxy, CH.sub.2 OCH.sub.3 or CH.sub.2 OCH.sub.2 CH.sub.3.
EP-A-No. 187,489 discloses herbicidal sulfonamides of the formula ##STR20## wherein L is ##STR21## Q is an optionally substituted 3- or 4-membered ring; and W is substituted alkenyl or alkynyl.
SUMMARY OF THE INVENTION
This application pertains to novel compounds of Formula I, agriculturally suitable compositions containing them and their method-of-use as preemergent and/or postemergent herbicides or plant growth regulants. ##STR22## wherein J is ##STR23## wherein R is H or CH.sub.3 ;
E is a single bond or CH.sub.2 ;
W is O, S or NR.sub.x ;
R.sub.x is H, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy;
R.sub.1 is H, F, Cl, Br, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkoxy or C.sub.1 -C.sub.3 thioalkyl;
R.sub.2 is H, Cl, Br, F, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, cyclopropyl optionally substituted by 1-4 halogen, cyclobutyl optionally substituted by 1-4 halogen, C.sub.2 -C.sub.4 alkenyl optionally substituted by halogen, C.sub.2 -C.sub.4 alkynyl optionally substituted by halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, NO.sub.2, CO.sub.2 R.sub.3, NR.sub.4 R.sub.5, S(O).sub.n R.sub.6, SO.sub.2 NR.sub.7 R.sub.8, C(O)NR.sub.9 R.sub.10, ##STR24## n is 0, 1 or 2; R.sub.3 is C.sub.1 -C.sub.3 alkyl, C.sub.2 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.3 -C.sub.4 alkenyl, CH.sub.2 (C.sub.3 -C.sub.5 cycloalkyl) or C.sub.3 -C.sub.4 alkynyl;
R.sub.4 is H or C.sub.1 -C.sub.2 alkyl;
R.sub.5 is C.sub.1 -C.sub.2 alkyl;
R.sub.6 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkoxyalkyl or C.sub.1 -C.sub.3 haloalkyl;
R.sub.7 is H or C.sub.1 -C.sub.2 alkyl;
R.sub.8 is C.sub.1 -C.sub.2 alkyl or C.sub.1 -C.sub.2 alkoxy;
R.sub.9 is H or C.sub.1 -C.sub.3 alkyl;
R.sub.10 is C.sub.1 -C.sub.3 alkyl;
R.sub.11 is H or CH.sub.3 ;
R.sub.12 is H or CH.sub.3 ;
R.sub.13 is H, C.sub.1 -C.sub.3 alkyl, allyl, C.sub.1 -C.sub.3 haloalkyl or C.sub.1 -C.sub.3 alkyl substituted with C.sub.1 -C.sub.2 alkoxy;
R.sub.13 ' is H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, allyl, C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 haloalkoxy or C.sub.1 -C.sub.2 alkylthio;
R.sub.13 " is H, C.sub.1 -C.sub.3 alkyl, allyl or C.sub.1 -C.sub.3 haloalkyl;
R.sub.14 is C.sub.1 -C.sub.3 alkyl, CH.sub.2 OCH.sub.3 or CH.sub.2 CN;
A is ##STR25## X is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, halogen, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy, amino, C.sub.1 -C.sub.3 alkylamino or di(C.sub.1 -C.sub.3 alkyl)amino;
Y is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy, amino, C.sub.1 -C.sub.3 alkylamino, di(C.sub.1 -C.sub.3 alkyl)amino, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, C.sub.2 -C.sub.5 alkylthioalkyl, C.sub.2 -C.sub.5 alkylsulfinylalkyl, C.sub.2 -C.sub.5 alkylsulfonylalkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.4 alkynyl, C.sub.3 -C.sub.5 cycloalkyl, azido, cyano, ##STR26## or N(OCH.sub.3)CH.sub.3 ; m is 2 or 3;
Q.sub.1 and Q.sub.2 are independently O or S;
R.sub.a is H or C.sub.1 -C.sub.3 alkyl;
R.sub.b and R.sub.c are independently C.sub.1 -C.sub.3 alkyl;
Z is CH, N, CCH.sub.3, CC.sub.2 H.sub.5, CCl or CBr;
Y.sub.1 is O or CH.sub.2 ;
X.sub.1 is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5 or OCF.sub.2 H;
X.sub.2 is CH.sub.3, C.sub.2 H.sub.5 or CH.sub.2 CF.sub.3 ;
Y.sub.2 is OCH.sub.3, OC.sub.2 H.sub.5, SCH.sub.3, SC.sub.2 H.sub.5, CH.sub.3 or CH.sub.2 CH.sub.3 ;
X.sub.3 is CH.sub.3 or OCH.sub.3 ;
Y.sub.3 is H or CH.sub.3 ;
X.sub.4 is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5, CH.sub.2 OCH.sub.3 or Cl;
Y.sub.4 is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5 or Cl;
and their agriculturally suitable salts; provided that
(1) when X is halogen, then Z is CH and Y is OCH.sub.3, OC.sub.2 H.sub.5, NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2, OCF.sub.2 H, OCF.sub.2 Br or N(OCH.sub.3)CH.sub.3 ;
(2) when X or Y is C.sub.1 haloalkoxy, then Z is CH;
(3) when W is S, then R is H, E is a single bond, A is A-1, Z is CH or N, and Y is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5, CH.sub.2 OCH.sub.3, C.sub.2 H.sub.5, CF.sub.3, SCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2, OCH.sub.2 C.tbd.CH, OCH.sub.2 CH.sub.2 OCH.sub.3, CH(OCH.sub.3).sub.2 or ##STR27## (4) when the total number of carbon atoms of X and Y is greater than four, then the combined number of carbons of R.sub.1 and R.sub.2 is less than or equal to six; and
(5) X.sub.4 and Y.sub.4 are not simultaneously Cl.
In the above definitions, the term "alkyl", used either alone or in compound words such as "alkylthio" or "haloalkyl", denotes straight chain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or the different butyl isomers.
Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the different butoxy isomers.
Alkenyl denotes straight chain or branched alkenes, e.g., vinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.
Alkynyl denotes straight chain or branched alkynes, e.g., ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers.
The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl" said alkyl may be monohalogenated or fully substituted with halogen atoms, which may be the same or different. Examples of haloalkyl include CH.sub.2 CH.sub.2 F, CF.sub.2 CF.sub.3 and CH.sub.2 CHFCl.
Similarly, the terms haloalkoxy and haloalkylthio would include groups which are mono- or poly-substituted with halogen atoms, which may be the same or different.
The total number of carbon atoms in a substituent group is indicated by the C.sub.i -C.sub.j prefix where i and j are numbers from 1 to 5. For example, C.sub.2 -C.sub.4 alkenyl would designate ethenyl through butenyl.
Preferred for reasons of increased ease of synthesis and/or greater herbicidal efficacy are:
1. Compounds of Formula I where
X is C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, Cl, F, Br, I, OCF.sub.2 H, CH.sub.2 F, CF.sub.3, OCH.sub.2 CH.sub.2 F, OCH.sub.2 CHF.sub.2, OCH.sub.2 CF.sub.3, CH.sub.2 Cl or CH.sub.2 Br; and
Y is H, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, CH.sub.2 OCH.sub.3, CH.sub.2 OCH.sub.2 CH.sub.3, NHCH.sub.3, N(OCH.sub.3)CH.sub.3, N(CH.sub.3).sub.2, CF.sub.3, SCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2, OCH.sub.2 C.tbd.CH, OCH.sub.2 CH.sub.2 OCH.sub.3, CH.sub.2 SCH.sub.3, C(O)R.sub.a, ##STR28## OCF.sub.2 H, SCF.sub.2 H, OCF.sub.2 Br, cyclopropyl, C.tbd.CH or C.tbd.CCH.sub.3 ;
Z is CH or N; and
R.sub.a is H or CH.sub.3.
2. Compounds of Preferred 1 where
E is a single bond;
W is O; and
R.sub.1 is H, F, Cl, Br, CH.sub.3, C.sub.1 haloalkyl or OCH.sub.3.
3. Compounds of Preferred 1 where
E is CH.sub.2 ;
W is O; and
R.sub.1 is H, F, Cl, Br, CH.sub.3 or OCH.sub.3.
4. Compounds of Preferred 2 where
R.sub.2 is H, Cl, Br, F, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 haloalkyl, cyclopropyl, C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 haloalkoxy, CF.dbd.CFCl, CF.dbd.CFCF.sub.3, NO.sub.2, CO.sub.2 R.sub.3, NR.sub.4 R.sub.5, S(O).sub.n R.sub.6, SO.sub.2 NR.sub.7 R.sub.8, SO.sub.2 N(OCH.sub.3)CH.sub.3, C(O)NR.sub.9 R.sub.10, R.sub.2 -A, R.sub.2 -B, R.sub.2 -E, R.sub.2 -J, R.sub.2 -N, R.sub.2 -Q, R.sub.2 -R, R.sub.2 -X, R.sub.2 -Y, R.sub.2 -AB, R.sub.2 -AC or R.sub.2 -AD;
R.sub.3 is CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 OCH.sub.3 or CH.sub.2 CH.sub.2 Cl;
R.sub.4 is H or CH.sub.3 ;
R.sub.6 is C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl or allyl;
R.sub.7 is H or CH.sub.3 ;
R.sub.8 is C.sub.1 -C.sub.2 alkyl
R.sub.9 is H or CH.sub.3 ;
R.sub.10 is CH.sub.3 or CH.sub.2 CH.sub.3 ;
R.sub.13 is H, CH.sub.3, CH.sub.2 CH.sub.3 or CH.sub.2 CH.sub.2 OCH.sub.3 ; and
R.sub.13 " is H, CH.sub.3 or CH.sub.2 CH.sub.3.
5. Compounds of Preferred 4 where
X is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, Cl, OCF.sub.2 H or OCH.sub.2 CF.sub.3 ;
Y is CH.sub.3, OCH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 OCH.sub.3, NHCH.sub.3 or CH(OCH.sub.3).sub.2.
6. Compounds of Preferred 5 where
J is J.sub.1 ; and
A is A-1.
7. Compounds of Preferred 5 where
J is J.sub.2 ; and
A is A-1.
8. Compounds of Preferred 5 where
J is J.sub.3 ; and
A is A-1.
9. Compounds of Preferred 5 where
J is J.sub.4 ; and
A is A-1.
Specifically preferred for reasons of greatest ease of synthesis and/or greatest herbicidal efficacy are:
N[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide, m.p. 155.degree.-157.degree. C.; and
N[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-pyridinesulfonamide-1-oxide, m.p. 172.degree.-176.degree. C.
DETAILED DESCRIPTION OF THE INVENTION
Synthesis
Compounds of Formula I can be prepared by one or more of the procedures shown in Equations 1, 4, and 5. J, R, and A are as previously defined. ##STR29##
The reaction of Equation 1 is best carried out in an inert aprotic organic solvent such as dichloromethane, 1,2-dichloroethane, tetrahydrofuran, or acetonitrile, at a temperature between 20.degree. and 85.degree. C. The order of addition is not critical; however, it is often convenient to add the sulfonyl isocyanate or a solution of it in the reaction solvent, to a stirred suspension of the amine.
In some cases, the desired product is insoluble in the reaction solvent at ambient temperature and crystallizes from it in pure form. Products soluble in the reaction solvent are isolated by evaporation of the solvent. Compounds of Formula I then may be purified by trituration of the evaporation residue with solvents such as 1-chlorobutane or ethyl ether and filtration, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane and heptane or by chromatography on silica gel.
Sulfonyl isocyanates (II, W is O) are known in the art and are prepared from the corresponding sulfonamides (IV) by one of the following two general methods. ##STR30##
The sulfonamide IV is reacted with an alkyl isocyanate (e.g., n-butyl isocyanate) in a solvent whose boiling point is above 135.degree. C., such as xylene. The reaction can optionally be carried out in the presence of a catalytic amount of 1,4-diaza[2.2.2]bicyclooctane (DABCO). The reaction mixture is heated to 135.degree.-140.degree. C. and held at that temperature for 5-60 minutes, after which phosgene is slowly added at such a rate that the temperature remains between 133 and 135.degree. C. When the consumption of phosgene has ceased, the mixture is cooled and filtered to remove insoluble material. Finally, the solvent, alkyl isocyanate, and excess phosgene are evaporated, leaving the sulfonyl isocyanate (II).
If desired, the alkyl isocyanate-sulfonamide adduct can be made and isolated before reaction with the phosgene. In this case the sulfonamide (IV), alkyl isocyanate, and anhydrous base (e.g, K.sub.2 CO.sub.3) in a polar, aprotic solvent (e.g. acetone, butanone, or acetonitrile) are mixed and heated under reflux for 1 to 6 hours. The reaction mixture is then diluted with water, and the pH is adjusted to about 3 with acid (e.g. HCl, H.sub.2 SO.sub.4). The adduct is filtered out and dried, and then reacted with phosgene as described above. This procedure modification is especially useful when sulfonamide (IV) is high melting and has low solubility in the phosgenation solvent.
Sulfonyl isocyanates (II, W is O) can also be prepared by the following method. ##STR31##
The sulfonamide (IV) is heated at reflux in an excess of thionyl chloride. The reaction is continued until the sulfonamide protons are no longer detectable in the proton magnetic resonance spectrum. From 16 hours to 5 days is typically sufficient for complete conversion to the thionylamide (V) (Equation 3a).
The thionyl chloride is evaporated and the residue is treated with an inert solvent (e.g. toluene) containing at least one equivalent (typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine (typically 0.1 equivalent ) is added, and the mixture is heated to about 60.degree.-140.degree. C., with 80.degree.-100.degree. C. preferred. Conversion to the isocyanate (II, W is O) is usually substantially complete within 15 minutes to 3 hours (Equation 3b). The mixture is then cooled and filtered, and the solvent is evaporated, leaving the sulfonyl isocyanate (II, W is O).
Sulfonyl isothiocyanates (II, W is S) are known in the art and are prepared from the corresponding sulfonamides (IV) by reaction with carbon disulfide and potassium hydroxide followed by treatment of the resulting dipotassium salt VI with phosgene. Such a procedure is described in Arch. Pharm. 299, 174 (1966).
Many of the compounds of Formula I can be prepared by the procedure shown in Equation 4. ##STR32##
The reaction of Equation 4 is carried out by contacting phenylcarbamates or phenylthiocarbamates of Formula VI with aminoheterocycles of Formula III in an inert organic solvent such as dioxane or tetrahydrofuran at temperatures of about 20.degree.-100.degree. C. for a period of about one-half to twenty-four hours. The product can be isolated by evaporation of the reaction solvent and purified by methods previously described.
Phenylcarbamates and phenylthiocarbamates of Formula VI can be prepared by the methods described, or modifications thereof known to those skilled in the art, in U.S. Pat. No. 4,443,243.
Alternatively, many of the compounds of Formula I can be prepared by the method described in Equation 5. ##STR33##
The reaction of Equation 5 can be carried out by contacting equimolar amounts of a sulfonamide of Formula IV with a heterocyclic phenylcarbamate or phenylthiocarbamate of Formula VII in the presence of a base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), by methods analogous to those described in South African Patent Application 83/0441. The phenylcarbamates and phenylthiocarbamates of Formula VII can be prepared by methods, or modifications thereof known to those skilled in the art, described in South African Patent Application No. 82/5671 and South African Patent Application No. 82/5045.
The sulfonamides IV of this invention may be prepared in a variety of ways, some of which are described in Equations 6 through 13.
For example, pyridine sulfonamides such as 1 may be oxidized directly to the corresponding N-oxide 2, using a variety of oxidants. Some of the oxidants of choice are m-chloroperoxybenzoic acid, CF.sub.3 CO.sub.3 H, H.sub.2 O.sub.2, etc. This is outlined in Equation 6. ##STR34##
In Equation 6, R.sub.1 and R.sub.2 are as previously defined, with the exception that R.sub.2 cannot be a group which will react with a strong oxidant (i.e., thioalkyl, alkenyl, etc.). In addition, isomers of sulfonamide 2, that is sulfonamides such as 3, 4 and 5 may also be prepared in the same manner as outlined in Equation 6. ##STR35##
Preparation of pyridine sulfonamides such as 1 (and its isomers) is well known to one skilled in the art. For further details pertaining to the preparation of pyridine sulfonamides see, U.S. Pat No. 4,544,401 (3-pyridine sulfonamides), U.S. Pat. No. 4,435,206 (2-pyridine sulfonamides), U.S. Pat. Nos. 4,456,469, 4,342,587 and EP-A-No. 165,753.
Preparation of sulfonamides such as 2, 3, 4 and 5 may also be accomplished utilizing organo lithium chemistry as outlined in Equations 7 through 10. ##STR36##
The methodology outlined in Equations 7-10 is applicable to a wide variety of derivatives where R.sub.1 and R.sub.2 are compatible with organo metallic conditions. For example, sulfonamide 2a where R.sub.1 is H and R.sub.2 is CO.sub.2 CH.sub.3 may be prepared as outlined in Equation 11. ##STR37##
An alternate synthesis of sulfonamides such as 2, (also applicable to other isomers) is to introduce the n-oxide functionality into the pyridine ring at the beginning of the synthetic scheme rather than the end of the synthesis. This is outlined in Equation 12. ##STR38##
Preparation of sulfonamides such as 2 where R.sub.2 is incompatible with reagents such as BuLi or LDA may be carried out in a variety of ways. For example, preparation of sulfonamides 10 and 12 utilizing fluoride 11 is outlined in Equation 13. ##STR39##
In Equation 13, introduction of the N-oxide functionality may be strategically done at any point of the synthesis. This then allows for the introduction of a functionality in R.sub.2 which is sensitive to strong oxidants (i.e., thioalkyl, alkenyl, etc.) as discussed in Equation 6.
For further details pertaining to lithiations of pyridine ring systems see, Epsztarjn et al., Tetrahedron Lett., 4739 (1980); Snieckus et al., J. Am. Chem. Soc., 102, 1457 (1980); Kuraishi et al., Tet. Lett., 2049 (1983); Meyers et al., J. Org. Chem., 47, 2633 (1982); Taylor et al., J. Org. Chem., 48, 4156 (1983) and Breant et al., Synthesis, 822 (1983).
For further details pertaining to the oxidation of pyridines to pyridine N-oxides see, Evans et al., Rec. Trav., 78, 408 (1959).
For a general treatment of pyridines and pyridine N-oxides see, Katritzky, A. R., and Rees, C. W., "Comprehensive Heterocyclic Chemistry", Vol. 2, Pergamon Press, Oxford, New York, Part 2A, 1984.
The synthesis of heterocyclic amines such as those represented by Formula III has been reviewed in "The Chemistry of Heterocyclic Compounds," a series published by Interscience Publ., New York and London. Aminopyrimidines are described by D. J. Brown in "The Pyrimidines," Vol. XVI of the series mentioned above which is herein incorporated by reference. The 2-amino-1,3,5-triazines of Formula III, where A is A-1 and Z is N, can be prepared according to methods described by E. M. Smolin and L. Rapaport in "s-Triazines and Derivatives," Vol. XIII.
Pyrimidines of Formula III, where A is A-1 and Y is an acetal or thioacetal substituent, can be prepared by methods taught in European Patent Application No. 84,224 (published July 27, 1983).
Pyrimidines of Formula III, where A is A-1 and Y is cyclopropyl or OCF.sub.2 H can be synthesized according to the methods taught in U.S. Pat. No. 4,515,626 and U.S. Pat. No. 4,540,782, respectively.
Compounds of Formula III, where A is A-2 or A-3, can be prepared by procedures disclosed in U.S. Pat. No. 4,339,267.
Compounds of Formula III, where A is A-4, can be prepared by methods taught in U.S. Pat. No. 4,487,626.
Additional references dealing with the synthesis of bicyclic pyrimidines of Formula III, where A is A-2, A-3, or A-4 are Braker, Sheehan, Spitzmiller and Lott, J. Am. Chem. Soc., 69, 3072 (1947); Mitler and Bhattachanya, Quart. J. Indian Chem. Soc., 4, 152 (1927); Shrage and Hitchings, J. Org. Chem., 16, 1153 (1951); Caldwell, Kornfeld and Donnell, J. Am. Chem. Soc., 63, 2188 (1941); and Fissekis, Myles and Brown, J. Org. Chem., 29, 2670 (1964).
Compounds of Formula III, where A is A-5, can be prepared by methods taught in U.S. Pat. No. 4,421,550.
Compounds of Formula III, where A is A-6, can be prepared by methods taught in the U.S. Pat. No. 4,496,392.
Compounds of Formula III, where A is A-7 can be prepared by methods taught in EP-A-No. 125,864.
Agriculturally suitable salts of compounds of Formula I are also useful herbicides and can be prepared in a number of ways known to the art. For example, metal salts can be made by contacting compounds of Formula I with a solution of an alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide, carbonate or hydroxide). Quaternary amine salts can be made by simlar techniques.
Salts of compounds of Formula I can also be prepared by exchange of one cation for another. Cationic exchange can be effected by direct contact of an aqueous solution of a salt of a compound of Formula I (e.g., alkali or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water and can be separated by filtration.
Exchange may also beeffected by passing an aqueous solution of a salt of a compound of Formula I (e.g., an alkali metal or quaternary amine salt) through a column packed with a cation exchange resin containing the cation to be exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water-soluble, e.g., a potassium sodium or calcium salt.
Acid addition salts, useful in this invention, can be obtained by reacting a compound of Formula I with a suitable acid, e.g., p-toluenesulfonic acid, trichloroacetic acid or the like.





The preparation of the compounds of this invention is further illustrated by the following specific examples. Unless otherwise indicated, temperatures are in degrees centigrade.
EXAMPLE 1
Preparation of 3-Methyl-2-(phenylmethylthio)pyridine
To a solution of NaH (2.4 g, 99 mmol) in 100 mL of DMF cooled to 0.degree. C. is added benzylmercaptan (12.3 g, 99 mmol). The solution was allowed to warm to room temperature then recooled to 0.degree. C. 2-Fluoro-3-methylpyridine in 10 mL DMF was added dropwise and stirred at room temperature overnight. The solution was diluted with H.sub.2 O, extracted twice with Et.sub.2 O, twice with EtOAc, and the combined organics washed twice with saturated NaHCO.sub.3, dried and concentrated. The resulting oil was flash chromatographed (10% Et.sub.2 O/hexane (v/v)) to yield 16.3 g of the desired product. NMR (200 MHz, CDCl.sub.3) .delta. 2.24 (s, 3H), 4.50 (s, 2H), 6.9 (dd, 1H), 7.2 (m, 5H), 7.4 (d, 1H) and 8.3 (d, 1H).
EXAMPLE 2
Preparation of N-(1,1-Dimethylethyl)-3-methyl-2-pyridinesulfonamide
To a vigorously stirring mixture of 3-methyl-2-(phenylmethylthio)pyridine (25 g, 116 mmol) CH.sub.2 Cl.sub.2 (500 mL) and H.sub.2 O (260 mL) cooled to 0.degree. C. was added 45 mL concentrated HCl. Chlorox.RTM. (500 mL) was then added dropwise between 0.degree. to -5.degree. C. The reaction was stirred 1 hour at 0.degree. C. and then extracted with CH.sub.2 Cl.sub.2. The organic extracts were cooled to -70.degree. C. and tert-butylamine (50 mL) was added dropwise. The solution was allowed to slowly warm to room temperature, diluted with H.sub.2 O and extracted with CH.sub.2 Cl.sub.2. The organics were dried and concentrated to an oil. The oil was triturated with Et.sub.2 O/hexane to afford 10 g of the desired product, m.p. 107.degree.-110.degree. C.; NMR (200 MHz, CDCl.sub.3) .delta. 1.27 (s, 9H), 2.68 (s, 3H), 5.138 (br s, 1H), 7.35 (dd, 1H), 7.62 (d, 1H) and 8.4 (d, 1H).
EXAMPLE 3
Preparation of N-(1,1-Dimethylethyl)-3-methyl-2-pyridinesulfonamide-1-oxide
To a stirring solution of 3-methyl-2-tert-butylpyridinesulfonamide (3.2 g, 14.0 mmol) in 100 mL of CH.sub.2 Cl.sub.2 was added m-chloroperoxybenzoic acid (2.8 g, 14.0 mmol). The solution was stirred overnight at room temperature, washed once with brine, twice with saturated NaHCO.sub.3, dried and concentrated. The resulting oil was flash chromatographed (25% EtOAc/hexane (v/v)) to yield 3.0 g of the desired product, m.p. 124.degree.-126.degree. C. NMR (200 MHz, CDCl.sub.3) .delta. 1.25 (s, 9H), 2.7 (s, 3H), 7.1 (br s, 1H), 7.26 (m, 2H) and 8.2 (d, 1H).
EXAMPLE 4
Preparation of 3-Methyl-2-pyridinesulfonamide-1-oxide
A mixture of the N-oxide of N-(1,1-dimethylethyl)-3-methyl-2-pyridinesulfonamide (2.5 g, 8.2 mmol) and 50 mL of CF.sub.3 CO.sub.2 H were stirred for 6 hours. The CF.sub.3 CO.sub.2 H was removed under vacuum and the resulting solids were washed with butyl chloride to afford 1 g of the desired product, m.p. 233.degree.-235.degree. C., (M.sup.+ =188, expected, 188).
EXAMPLE 5
Preparation of N-[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide
To a stirring solution of the N-oxide of 3-methyl-2-pyridinesulfonamide (150 mg, 0.79 mmol) and the phenylcarbamate of 4,6-dimethyl-2-aminopyridine (194 mg, 0.79 mmol) in 3 mL of CH.sub.3 CN was added DBU (121 mg, 0.79 mmol). The solution was stirred for 15 minutes. Three mL of H.sub.2 O, then 3 mL of 5% HCl was added to the reaction and the resulting solid was collected, m.p. 161.degree.-163.degree. C. NMR (200 MHz, d.sub.6 -DMSO) .delta. 2.36 (s, 6H), 2.59 (s, 3H), 6.97 (s, 1H), 7.4 (d, 1H), 7.5 (d, 1H), 8.3 (d, 1H), 10.6 (br s, 1H) and 13.3 (br s, 1H).
EXAMPLE 6
Preparation of 3-Chloro-2-pyridinesulfonamide-1-oxide
To a stirring solution of 3-chloro-2-pyridinesulfonamide (2.5 g, 13.0 mmol) in 35 mL of trifluoroacetic acid was added 30% H.sub.2 O.sub.2 (1.2 g, 35.1 mmol). The solution was concentrated to .about.15 mL, diluted with ethyl acetate, washed twice with brine, dried and concentrated. The resulting solid was flash chromatographed with EtOAc to afford the desired product, m.p. 195.degree.-197.degree. C.
EXAMPLE 7
Preparation of 3-Chloro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-pyridinesulfonamide-1-oxide
To a stirring solution of the N-oxide of 3-chloro-2-pyridinesulfonamide (85 mg, 0.4 mmol) and the phenyl carbamate of 4,6-dimethoxy-2-aminopyrimidine (114 mg, 0.40 mmol) in acetonitrile was added DBU (62 mg, 0.40 mmol). Addition of H.sub.2 O followed by 5% HCl caused a precipitate to form which was collected, m.p. 144.degree.-147.degree. C. NMR (200 MHz, d.sub.6 -DMSO) .delta. 3.91 (s, 6H), 5.998 (s, 1H), 7.7 (m, 2H), 8.4 (d, 1H), 10.8 (br s, 1H) and 13.1 (br s, 1H); IR (nujol) 1710 (s) cm.sup.-1 ; mass spectrum m/e 390 (M.sup.+, calc. for C.sub.12 H.sub.12 ClN.sub.5 O.sub.6 S 389+1).
EXAMPLE 8
Preparation of 6-methylthio-3-carboxy-2-pyridinesulfonamide-1-oxide methyl ester
To a stirring solution of n-butyllithium in 150 ml of tetrahydrofuran cooled to -78.degree. C. was added 6-methylthio-2-pyridine-t-butylsulfonamide-1-oxide (30 g, 10.9 mmol) dropwise. The solution was stirred for one hour at -78.degree. C. followed by dropwise addition of methylchloroformate (5.1 g, 53.4 mmol). The solution was warmed to 0.degree. C. and quenched with brine. The organic layer was separated, dryed and concentrated to an oil. The resulting oil was subjected to MPLC with a 25% EtOAc-hexane (v/v) to afford 710 mg of product. This was then submitted to trifluroacetic acid (25 ml) for 24 hours. Removal of the acid and triteration with BuCl afforded 400 mg of the desired sulfonamide: m.p. 199.degree.-202; NMR (200 MHz, DMSO) .delta. 2.48 (s, 3H), 3.78 (s, 3H), 7.60 (br s, 2H); mass spectrum m/e 279 (M.sup.+, calc. for C.sub.8 H.sub. 10 NO.sub.5 S.sub.2 278+1).
COMPOUND TABLES______________________________________Structure of J Substituentin Tables I-IV______________________________________Table IJ is J-1 ##STR40##Table IIJ is J-2 ##STR41##Table IIIJ is J-3 ##STR42##Table IVJ is J-4 ##STR43##______________________________________
TABLE I__________________________________________________________________________R A E W R.sub.1 R.sub.2 X Y Z m.p.(.degree.C.)__________________________________________________________________________H A-1 -- O H H CH.sub.3 CH.sub.3 CH 169-172H A-1 -- O H H CH.sub.3 OCH.sub.3 CH 173-175H A-1 -- O H H OCH.sub.3 OCH.sub.3 CH 179-183H A-1 -- O H H CH.sub.3 CH.sub.3 N 149-166H A-1 -- O H H CH.sub.3 OCH.sub.3 N 172-176H A-1 -- O H H OCH.sub.3 OCH.sub.3 N 167-170H A-1 -- O H H Cl OCH.sub.3 CHH A-1 -- O H Cl CH.sub.3 CH.sub.3 CH 147-149H A-1 -- O H Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H Cl OCH.sub.3 OCH.sub.3 CH 144-147H A-1 -- O H Cl CH.sub.3 CH.sub.3 NH A-1 -- O H Cl CH.sub.3 OCH.sub.3 N 130-132H A-1 -- O H Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H Cl Cl OCH.sub.3 CH 162-164H A-1 -- O H Br CH.sub.3 CH.sub.3 CHH A-1 -- O H Br CH.sub.3 OCH.sub.3 CHH A-1 -- O H Br OCH.sub.3 OCH.sub.3 CHH A-1 -- O H Br CH.sub.3 CH.sub.3 NH A-1 -- O H Br CH.sub.3 OCH.sub.3 NH A-1 -- O H Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H Br Cl OCH.sub.3 CHH A-1 -- O H F CH.sub.3 CH.sub.3 CHH A-1 -- O H F CH.sub.3 OCH.sub.3 CHH A-1 -- O H F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H F CH.sub.3 CH.sub.3 NH A-1 -- O H F CH.sub.3 OCH.sub.3 NH A-1 -- O H F OCH.sub.3 OCH.sub.3 NH A-1 -- O H F Cl OCH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 CH 161-163H A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 CH 150-152H A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 CH 155-157H A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 N 130-132H A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 N 156-158H A-1 -- O H CH.sub.3 Cl OCH.sub.3 CH 160-162H A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CH 147-150H A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CH 158-160H A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CH 175-178H A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 N 179-181H A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 N 183-185H A-1 -- O H CH.sub.2 CH.sub.3 Cl OCH.sub.3 CH 181-183H A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CH 143-147H A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CH 189-191H A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub. 3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H (CH.sub.2).sub.4 CH.sub.3 OCH.sub.3 OCH.sub.3 CH 178-180H A-1 -- O H CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H CF.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H CCl.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H CCl.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H CCl.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 CH 167-169H A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 CH 146-148H A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 CH 178-180H A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 NH A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 NH A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 N 182-184H A-1 -- O H cyclopropyl Cl OCH.sub.3 CHH A-1 -- O H ##STR44## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR45## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR46## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR47## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR48## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR49## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR50## Cl OCH.sub.3 CHH A-1 -- O H ##STR51## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR52## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR53## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR54## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR55## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR56## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR57## Cl OCH.sub.3 CHH A-1 -- O H ##STR58## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR59## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR60## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR61## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR62## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR63## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR64## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR65## Cl OCH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 CH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclobutyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 CH.sub.3 NH A-1 -- O H cyclobutyl CH.sub.3 OCH.sub.3 NH A-1 -- O H cyclobutyl OCH.sub.3 OCH.sub.3 NH A-1 -- O H cyclobutyl Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CFCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CFCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CHFCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CHFCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CHFCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CHFCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CCCH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CCCH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H CCCH.sub.2 F CH.sub.3 OCH.sub. 3 CHH A-1 -- O H CCCH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCCH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H OCF.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Br CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CCH CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H NO.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2C CH CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 CH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) OCH.sub.3 OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 CH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 OCH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) OCH.sub.3 OCH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 OCH.sub. 3 OCH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SONHCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.2)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 Cl OCH.sub. 3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CONHCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CONHCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CONHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CONHCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H ##STR66## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR67## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR68## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR69## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR70## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR71## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR72## Cl OCH.sub.3 CHH A-1 -- O H ##STR73## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR74## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR75## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR76## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR77## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR78## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR79## Cl OCH.sub.3 CHH A-1 -- O H ##STR80## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR81## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR82## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR83## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR84## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR85## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR86## Cl OCH.sub.3 CHH A-1 -- O H ##STR87## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR88## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR89## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR90## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR91## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR92## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR93## Cl OCH.sub.3 CHH A-1 -- O H ##STR94## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR95## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR96## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR97## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR98## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR99## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR100## Cl OCH.sub.3 CHH A-1 -- O H ##STR101## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR102## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR103## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR104## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR105## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR106## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR107## Cl OCH.sub.3 CHH A-1 -- O H ##STR108## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR109## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR110## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR111## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR112## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR113## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR114## Cl OCH.sub.3 CHH A-1 -- O H ##STR115## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR116## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR117## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR118## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR119## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR120## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR121## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 Cl OCH.sub.3 CHCH.sub. 3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub. 2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR122## CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H ##STR123## CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR124## OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR125## CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H ##STR126## CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR127## OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR128## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR129## CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H ##STR130## CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR131## OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR132## CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H ##STR133## CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR134## OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR135## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR136## CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H ##STR137## CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR138## OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR139## CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H ##STR140## CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR141## OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR142## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub. 2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub. 3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub. 2 CH.sub.2CCH Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 6-F CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-F CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-F CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-F CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-F CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-F CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-F CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-F CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-F CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-F CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-F CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-F CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-F CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-F CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-F CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-F CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-F CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-F CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 6-F CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-F CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-F CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 6-F CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-F CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-F CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-F CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-F CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-F CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-F CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 6-Cl cyclopropyl CH.sub.3 CH.sub.3 CHH A-1 -- O 6-Cl cyclopropyl CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-Cl cyclopropyl CH.sub.3 CH.sub.3 NH A-1 -- O 6-Cl cyclopropyl CH.sub.3 OCH.sub.3 NH A-1 -- O 6-Cl cyclopropyl OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-Cl cyclopropyl Cl OCH.sub.3 CHH A-1 -- O 6-Cl ##STR143## CH.sub.3 CH.sub.3 CHH A-1 -- O 6-Cl ##STR144## CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-Cl ##STR145## OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-Cl ##STR146## CH.sub.3 CH.sub.3 NH A-1 -- O 6-Cl ##STR147## CH.sub.3 OCH.sub.3 NH A-1 -- O 6-Cl ##STR148## OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-Cl ##STR149## Cl OCH.sub.3 CHH A-1 -- O 6-Cl ##STR150## CH.sub.3 CH.sub.3 CHH A-1 -- O 6-Cl ##STR151## CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-Cl ##STR152## OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-Cl ##STR153## CH.sub.3 CH.sub.3 NH A-1 -- O 6-Cl ##STR154## CH.sub.3 OCH.sub.3 NH A-1 -- O 6-Cl ##STR155## OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-Cl ##STR156## Cl OCH.sub.3 CHH A-1 -- O 6-Cl ##STR157## CH.sub.3 CH.sub.3 CHH A-1 -- O 6-Cl ##STR158## CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-Cl ##STR159## OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-Cl ##STR160## CH.sub.3 CH.sub.3 NH A-1 -- O 6-Cl ##STR161## CH.sub.3 OCH.sub.3 NH A-1 -- O 6-Cl ##STR162## OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-Cl ##STR163## Cl OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.2 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Br CH.sub.3 CH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 NO.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.3 NO.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 NO.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 NO.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.3 NO.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 NO.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 NO.sub.2 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub. 3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub. 3 CH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-SOCH.sub.3 H CH.sub.3 CH.sub.3 CH 175-178H A-1 -- O 6-SOCH.sub.3 H CH.sub.3 OCH.sub.3 CH 163-166H A-1 -- O 6-SOCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 214-217H A-1 -- O 6-SOCH.sub.3 H OCH.sub.3 CH.sub.3 N 170-172H A-1 -- O 6-SOCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CCH CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SOCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 6-F SOCH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SOCH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SOCH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 6-F SOCH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SOCH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SOCH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-SCH.sub.3 SCH.sub.3 CH.sub.3 CH.sub.3 CH 174-176H A-1 -- O 6-SCH.sub.3 SCH.sub.3 CH.sub.3 OCH.sub.3 CH 169-171H A-1 -- O 6-SCH.sub.3 H CH.sub.3 CH.sub.3 CH 203-205H A-1 -- O 6-SCH.sub.3 H CH.sub.3 OCH.sub.3 CH 150-154H A-1 -- O 6-SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 189-192H A-1 -- O 6-SCH.sub.3 H CH.sub.3 OCH.sub.3 N 185-187H A-1 -- O 6-SCH.sub.3 H OCH.sub.3 OCH.sub.3 N 180-182H A-1 -- O 6-SCH.sub.3 H Cl OCH.sub.3 CH 186-188__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 Y.sub.1 m.p.(.degree.C.)__________________________________________________________________________H A-2 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2H A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2H A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2H A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OH A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OH A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCF.sub.2 H CH.sub.2H A-3 -- O H CO.sub.2 CH.sub.3 CH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 HH A-3 -- O H Cl CH.sub.3H A-3 -- O H Cl OCH.sub.3H A-3 -- O H SO.sub.2 CH.sub.3 CH.sub.3H A-3 -- O H SO.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 Y.sub.3 m.p.(.degree.C.)__________________________________________________________________________H A-4 -- O H CO.sub.2 CH.sub.3 CH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H HH A-4 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-4 -- O H CO.sub.2 CH.sub. 3 OCH.sub.3 CH.sub.3H A-4 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.2 Y.sub.2 m.p.(.degree.C.)__________________________________________________________________________H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 SCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CF.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.3 m.p(.degree.C.)__________________________________________________________________________H A-6 -- O H CO.sub.2 CH.sub.3 CH.sub.3H A-6 -- O H CO.sub.2 CH.sub.3 OCH.sub.3H A-6 -- O H NO.sub.2 CH.sub.3H A-6 -- O H NO.sub.2 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.4 Y.sub.4 m.p.(.degree.C.)__________________________________________________________________________H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 ClH A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X Y Z m.p.(.degree.C.)__________________________________________________________________________H A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CCH CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 cyclopropyl CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CN CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CN CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 Cl CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 Br CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub. 3).sub.2 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 cyclopropyl CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 CCH OCH.sub.2 CH.sub.3 CH__________________________________________________________________________
TABLE II__________________________________________________________________________ m.p.R A E W R.sub.1 R.sub.2 X Y Z (.degree.C.)__________________________________________________________________________H A-1 -- O H H CH.sub.3 CH.sub.3 CHH A-1 -- O H H CH.sub.3 OCH.sub.3 CHH A-1 -- O H H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H H CH.sub.3 CH.sub.3 NH A-1 -- O H H CH.sub.3 OCH.sub.3 NH A-1 -- O H H OCH.sub.3 OCH.sub.3 NH A-1 -- O H H Cl OCH.sub.3 CHH A-1 -- O H Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H Cl CH.sub.3 CH.sub.3 NH A-1 -- O H Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H Cl Cl OCH.sub.3 CHH A-1 -- O H Br CH.sub.3 CH.sub.3 CHH A-1 -- O H Br CH.sub.3 OCH.sub.3 CHH A-1 -- O H Br OCH.sub.3 OCH.sub.3 CHH A-1 -- O H Br CH.sub.3 CH.sub.3 NH A-1 -- O H Br CH.sub.3 OCH.sub.3 NH A-1 -- O H Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H Br Cl OCH.sub.3 CHH A-1 -- O H F CH.sub.3 CH.sub.3 CHH A-1 -- O H F CH.sub.3 OCH.sub.3 CHH A-1 -- O H F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H F CH.sub.3 CH.sub.3 NH A-1 -- O H F CH.sub.3 OCH.sub.3 NH A-1 -- O H F OCH.sub.3 OCH.sub.3 NH A-1 -- O H F Cl OCH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub. 3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H CF.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H CCl.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H CCl.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H CCl.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 NH A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 NH A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 NH A-1 -- O H cyclopropyl Cl OCH.sub.3 CH H A-1 -- O H ##STR164## CH.sub.3 CH.sub.3 CH H A-1 -- O H ##STR165## CH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR166## OCH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR167## CH.sub.3 CH.sub.3 N H A-1 -- O H ##STR168## CH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR169## OCH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR170## Cl OCH.sub.3 CH H A-1 -- O H ##STR171## CH.sub.3 CH.sub.3 CH H A-1 -- O H ##STR172## CH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR173## OCH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR174## CH.sub.3 CH.sub.3 N H A-1 -- O H ##STR175## CH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR176## OCH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR177## Cl OCH.sub.3 CH H A-1 -- O H ##STR178## CH.sub.3 CH.sub.3 CH H A-1 -- O H ##STR179## CH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR180## OCH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR181## CH.sub.3 CH.sub.3 N H A-1 -- O H ##STR182## CH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR183## OCH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR184## Cl OCH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 CH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclobutyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 CH.sub.3 NH A-1 -- O H cyclobutyl CH.sub.3 OCH.sub.3 NH A-1 -- O H cyclobutyl OCH.sub.3 OCH.sub.3 NH A-1 -- O H cyclobutyl Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CFCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CFCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CHFCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CHFCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CHFCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CHFCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CHCHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CCH CH.sub.3 OCH.sub. 3 NH A-1 -- O H CH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CCCH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CCCH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H CCCH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCCH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCCH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub. 2CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H OCF.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub. 3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Br CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H NO.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub. 2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub. 3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 CH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) OCH.sub.3 OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 CH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 OCH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) OCH.sub.3 OCH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub. 2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub. 2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub. 2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CONHCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CONHCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CONHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CONHCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H ##STR185## CH.sub. 3 CH.sub.3 CHH A-1 -- O H ##STR186## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR187## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR188## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR189## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR190## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR191## Cl OCH.sub.3 CHH A-1 -- O H ##STR192## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR193## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR194## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR195## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR196## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR197## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR198## Cl CHH A-1 -- O H ##STR199## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR200## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR201## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR202## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR203## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR204## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR205## Cl OCH.sub.3 CHH A-1 -- O H ##STR206## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR207## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR208## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR209## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR210## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR211## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR212## Cl OCH.sub.3 CHH A-1 -- O H ##STR213## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR214## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR215## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR216## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR217## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR218## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR219## Cl OCH.sub.3 CHH A-1 -- O H ##STR220## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR221## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR222## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR223## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR224## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR225## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR226## Cl OCH.sub.3 CHH A-1 -- O H ##STR227## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR228## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR229## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR230## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR231## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR232## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR233## Cl OCH.sub.3 CHH A-1 -- O H ##STR234## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR235## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR236## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR237## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR238## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR239## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR240## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 CH.sub. 3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl Cl OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR241## CH.sub.3 CH.sub.3 CH CH.sub.3 A-1 -- O H ##STR242## CH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR243## OCH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR244## CH.sub.3 CH.sub.3 N CH.sub.3 A-1 -- O H ##STR245## CH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR246## OCH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR247## Cl OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR248## CH.sub.3 CH.sub.3 CH CH.sub.3 A-1 -- O H ##STR249## CH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR250## OCH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR251## CH.sub.3 CH.sub.3 N CH.sub.3 A-1 -- O H ##STR252## CH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR253## OCH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR254## Cl OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR255## CH.sub.3 CH.sub.3 CH CH.sub.3 A-1 -- O H ##STR256## CH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR257## OCH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR258## CH.sub.3 CH.sub.3 N CH.sub.3 A-1 -- O H ##STR259## CH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR260## OCH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR261## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub. 2 CH.sub.2 F CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub. 3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub. 2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2C CH Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-F CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-F CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-F CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 5-F CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH(CH.sub.3 ).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-Cl cyclopropyl CH.sub.3 CH.sub.3 CHH A-1 -- O 5-Cl cyclopropyl CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl cyclopropyl CH.sub.3 CH.sub.3 NH A-1 -- O 5-Cl cyclopropyl CH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl cyclopropyl OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl cyclopropyl Cl OCH.sub.3 CH H A-1 -- O 5-Cl ##STR262## CH.sub.3 CH.sub.3 CH H A-1 -- O 5-Cl ##STR263## CH.sub.3 OCH.sub.3 CH H A-1 -- O 5-Cl ##STR264## OCH.sub.3 OCH.sub.3 CH H A-1 -- O 5-Cl ##STR265## CH.sub.3 CH.sub.3 N H A-1 -- O 5-Cl ##STR266## CH.sub.3 OCH.sub.3 N H A-1 -- O 5-Cl ##STR267## OCH.sub.3 OCH.sub.3 N H A-1 -- O 5-Cl ##STR268## Cl OCH.sub.3 CH H A-1 -- O 5-Cl ##STR269## CH.sub.3 CH.sub.3 CH H A-1 -- O 5-Cl ##STR270## CH.sub.3 OCH.sub.3 CH H A-1 -- O 5-Cl ##STR271## OCH.sub.3 OCH.sub.3 CH H A-1 -- O 5-Cl ##STR272## CH.sub.3 CH.sub.3 N H A-1 -- O 5-Cl ##STR273## CH.sub.3 OCH.sub.3 N H A-1 -- O 5-Cl ##STR274## OCH.sub.3 OCH.sub.3 N H A-1 -- O 5-Cl ##STR275## Cl OCH.sub.3 CH H A-1 -- O 5-Cl ##STR276## CH.sub.3 CH.sub.3 CH H A-1 -- O 5-Cl ##STR277## CH.sub.3 OCH.sub.3 CH H A-1 -- O 5-Cl ##STR278## OCH.sub.3 OCH.sub.3 CH H A-1 -- O 5-Cl ##STR279## CH.sub.3 CH.sub.3 N H A-1 -- O 5-Cl ##STR280## CH.sub.3 OCH.sub.3 N H A-1 -- O 5-Cl ##STR281## OCH.sub.3 OCH.sub.3 N H A-1 -- O 5-Cl ##STR282## Cl OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub. 2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Br CH.sub.3 CH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2C CH CH.sub.3 CH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2CHCH.sub.2 Cl OCH.sub. 3 CHH A-1 -- O 5-OCH.sub.3 NO.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 NO.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 NO.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 NO.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 NO.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 NO.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 NO.sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub. 3 CO.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 4-OCH.sub.3 SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 5-F SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NCH.sub. 3 A-1 -- O 5-F SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH.sub.2CCH CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 5-F SCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 5-F SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 5-F SCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SOCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 5-F SOCH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SOCH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SOCH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 5-F SOCH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 5-F SOCH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 5-F SOCH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 5-F SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 5-F SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 5-F SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 5-F SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 5-F SO.sub.2 CH.sub.3 Cl OCH.sub.3 CH__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 Y.sub.1 m.p. (.degree.C.)__________________________________________________________________________H A-2 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2H A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2H A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2H A-2 -- O H CO.sub.2 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OH A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OH A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCF.sub.2 H CH.sub.2H A-3 -- O H CO.sub.2 CH.sub.3 CH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 HH A-3 -- O H Cl CH.sub.3H A-3 -- O H Cl OCH.sub.3H A-3 -- O H SO.sub.2 CH.sub.3 CH.sub.3H A-3 -- O H SO.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 Y.sub.3 m.p. (.degree.C.)__________________________________________________________________________H A-4 -- O H CO.sub.2 CH.sub.3 CH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H HH A-4 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3H A-4 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.2 Y.sub.2 m.p. (.degree.C.)__________________________________________________________________________H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 SCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CF.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.3 m.p. (.degree.C.)__________________________________________________________________________H A-6 -- O H CO.sub.2 CH.sub.3 CH.sub.3H A-6 -- O H CO.sub.2 CH.sub.3 OCH.sub.3H A-6 -- O H NO.sub.2 CH.sub.3H A-6 -- O H NO.sub.2 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.4 Y.sub.4 m.p. (.degree.C.)__________________________________________________________________________H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub. 3 CH.sub.3 OCH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 ClH A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________ m.p.R A E W R.sub.1 R.sub.2 X Y Z (.degree.C.)__________________________________________________________________________H A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 CHH A-1 -- O H CO.sub. 2 CH.sub.3 CH.sub.3 NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CCH CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 cyclopropyl CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CN CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub. 3 OCH.sub.3 NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CN CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H N(CH.sub.3).sub.2 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H NHCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 Cl CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 Br CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 OCH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 F NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 cyclopropyl NH A-1 -- O H CO.sub.2 CH.sub.3 CCH CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH N(CH.sub.3).sub.2 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH OCH.sub.2 CH.sub.3 N__________________________________________________________________________
TABLE III__________________________________________________________________________R A E W R.sub.1 R.sub.2 X Y Z m.p.(.degree.C.)__________________________________________________________________________H A-1 -- O H H CH.sub.3 CH.sub.3 CHH A-1 -- O H H CH.sub.3 OCH.sub.3 CHH A-1 -- O H H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H H CH.sub.3 CH.sub.3 NH A-1 -- O H H CH.sub.3 OCH.sub.3 NH A-1 -- O H H OCH.sub.3 OCH.sub.3 NH A-1 -- O H H Cl OCH.sub.3 CHH A-1 -- O H Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H Cl CH.sub.3 CH.sub.3 NH A-1 -- O H Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H Cl Cl OCH.sub.3 CHH A-1 -- O H Br CH.sub.3 CH.sub.3 CHH A-1 -- O H Br CH.sub.3 OCH.sub.3 CHH A-1 -- O H Br OCH.sub.3 OCH.sub.3 CHH A-1 -- O H Br CH.sub.3 CH.sub.3 NH A-1 -- O H Br CH.sub.3 OCH.sub.3 NH A-1 -- O H Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H Br Cl OCH.sub.3 CHH A-1 -- O H F CH.sub.3 CH.sub.3 CHH A-1 -- O H F CH.sub.3 OCH.sub.3 CHH A-1 -- O H F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H F CH.sub.3 CH.sub.3 NH A-1 -- O H F CH.sub.3 OCH.sub.3 NH A-1 -- O H F OCH.sub.3 OCH.sub.3 NH A-1 -- O H F Cl OCH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H CF.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H CCl.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H CCl.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H CCl.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 NH A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 NH A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 NH A-1 -- O H cyclopropyl Cl OCH.sub.3 CH H A-1 -- O H ##STR283## CH.sub.3 CH.sub.3 CH H A-1 -- O H ##STR284## CH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR285## OCH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR286## CH.sub.3 CH.sub.3 N H A-1 -- O H ##STR287## CH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR288## OCH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR289## Cl OCH.sub.3 CH H A-1 -- O H ##STR290## CH.sub.3 CH.sub.3 CH H A-1 -- O H ##STR291## CH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR292## OCH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR293## CH.sub.3 CH.sub.3 N H A-1 -- O H ##STR294## CH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR295## OCH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR296## Cl OCH.sub.3 CH H A-1 -- O H ##STR297## CH.sub.3 CH.sub.3 CH H A-1 -- O H ##STR298## CH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR299## OCH.sub.3 OCH.sub.3 CH H A-1 -- O H ##STR300## CH.sub.3 CH.sub.3 N H A-1 -- O H ##STR301## CH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR302## OCH.sub.3 OCH.sub.3 N H A-1 -- O H ##STR303## Cl OCH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 CH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclobutyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 CH.sub.3 NH A-1 -- O H cyclobutyl CH.sub.3 OCH.sub.3 NH A-1 -- O H cyclobutyl OCH.sub.3 OCH.sub.3 NH A-1 -- O H cyclobutyl Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CFCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CFCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CHFCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CHFCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CHFCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CHFCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H C CH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CCCH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CCCH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H CCCH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCCH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCCH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H OCF.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Br CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2C CH CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H NO.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2C CH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 CH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) OCH.sub.3 OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 CH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 OCH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) OCH.sub.3 OCH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 OCH.sub. 3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 Cl OCH.sub. 3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub. 3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub. 3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub. 3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CONHCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CONHCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CONHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CONHCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H ##STR304## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR305## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR306## OCH.sub. 3 OCH.sub.3 CHH A-1 -- O H ##STR307## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR308## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR309## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR310## Cl OCH.sub.3 CHH A-1 -- O H ##STR311## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR312## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR313## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR314## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR315## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR316## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR317## Cl OCH.sub.3 CHH A-1 -- O H ##STR318## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR319## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR320## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR321## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR322## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR323## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR324## Cl OCH.sub.3 CHH A-1 -- O H ##STR325## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR326## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR327## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR328## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR329## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR330## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR331## Cl OCH.sub.3 CHH A-1 -- O H ##STR332## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR333## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR334## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR335## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR336## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR337## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR338## Cl OCH.sub.3 CHH A-1 -- O H ##STR339## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR340## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR341## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR342## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR343## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR344## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR345## Cl OCH.sub.3 CHH A-1 -- O H ##STR346## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR347## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR348## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR349## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR350## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR351## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR352## Cl OCH.sub.3 CHH A-1 -- O H ##STR353## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR354## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR355## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR356## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR357## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR358## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR359## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub. 3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub. 3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl Cl OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR360## CH.sub.3 CH.sub.3 CH CH.sub.3 A-1 -- O H ##STR361## CH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR362## OCH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR363## CH.sub.3 CH.sub.3 N CH.sub.3 A-1 -- O H ##STR364## CH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR365## OCH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR366## Cl OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR367## CH.sub.3 CH.sub.3 CH CH.sub.3 A-1 -- O H ##STR368## CH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR369## OCH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR370## CH.sub.3 CH.sub.3 N CH.sub.3 A-1 -- O H ##STR371## CH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR372## OCH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR373## Cl OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR374## CH.sub.3 CH.sub.3 CH CH.sub.3 A-1 -- O H ##STR375## CH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR376## OCH.sub.3 OCH.sub.3 CH CH.sub.3 A-1 -- O H ##STR377## CH.sub.3 CH.sub.3 N CH.sub.3 A-1 -- O H ##STR378## CH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR379## OCH.sub.3 OCH.sub.3 N CH.sub.3 A-1 -- O H ##STR380## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub. 3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2C CH OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 2-F CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-F CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-F CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-F CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 2-F CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-F CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-F CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 2-F CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-F CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-F CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-F CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 2-F CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-F CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-F CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 2-F CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-F CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-F CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-F CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 2-F CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-F CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-F CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 2-F CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-F CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-F CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-F CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 2-F CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-F CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-F CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 2-Cl cyclopropyl CH.sub.3 CH.sub.3 CHH A-1 -- O 2-Cl cyclopropyl CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-Cl cyclopropyl CH.sub.3 CH.sub.3 NH A-1 -- O 2-Cl cyclopropyl CH.sub.3 OCH.sub.3 NH A-1 -- O 2-Cl cyclopropyl OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-Cl cyclopropyl Cl OCH.sub.3 CH H A-1 -- O 2-Cl ##STR381## CH.sub.3 CH.sub.3 CH H A-1 -- O 2-Cl ##STR382## CH.sub.3 OCH.sub.3 CH H A-1 -- O 2-Cl ##STR383## OCH.sub.3 OCH.sub.3 CH H A-1 -- O 2-Cl ##STR384## CH.sub.3 CH.sub.3 N H A-1 -- O 2-Cl ##STR385## CH.sub.3 OCH.sub.3 N H A-1 -- O 2-Cl ##STR386## OCH.sub.3 OCH.sub.3 N H A-1 -- O 2-Cl ##STR387## Cl OCH.sub.3 CH H A-1 -- O 2-Cl ##STR388## CH.sub.3 CH.sub.3 CH H A-1 -- O 2-Cl ##STR389## CH.sub.3 OCH.sub.3 CH H A-1 -- O 2-Cl ##STR390## OCH.sub.3 OCH.sub.3 CH H A-1 -- O 2-Cl ##STR391## CH.sub.3 CH.sub.3 N H A-1 -- O 2-Cl ##STR392## CH.sub.3 OCH.sub.3 N H A-1 -- O 2-Cl ##STR393## OCH.sub.3 OCH.sub.3 N H A-1 -- O 2-Cl ##STR394## Cl OCH.sub.3 CH H A-1 -- O 2-Cl ##STR395## CH.sub.3 CH.sub.3 CH H A-1 -- O 2-Cl ##STR396## CH.sub.3 OCH.sub.3 CH H A-1 -- O 2-Cl ##STR397## OCH.sub.3 OCH.sub.3 CH H A-1 -- O 2-Cl ##STR398## CH.sub.3 CH.sub.3 N H A-1 -- O 2-Cl ##STR399## CH.sub.3 OCH.sub.3 N H A-1 -- O 2-Cl ##STR400## OCH.sub.3 OCH.sub.3 N H A-1 -- O 2-Cl ##STR401## Cl OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub. 2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Br CH.sub.3 CH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2 CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-CH.sub.3 OCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 NO.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-OCH.sub.3 NO.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 NO.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 NO.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 2-OCH.sub.3 NO.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.3 NO.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.3 NO.sub.2 Cl OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 2-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 2-F SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 2-F SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 2-F SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 2-F SCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 2-F SCH.sub.2CCH CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SCH(CH.sub.3).sub.2 OCH.sub. 3 OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 2-F SCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 2-F SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 2-F SCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SOCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 2-F SOCH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SOCH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SOCH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 2-F SOCH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 2-F SOCH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 2-F SOCH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 2-F SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 2-F SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 2-F SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 2-F SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 2-F SO.sub.2 CH.sub.3 Cl OCH.sub.3 CH__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 Y.sub.1 m.p.(.degree.C.)__________________________________________________________________________H A-2 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2H A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2H A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2H A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OH A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OH A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCF.sub.2 H CH.sub.2__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 m.p.(.degree.C.)__________________________________________________________________________H A-3 -- O H CO.sub.2 CH.sub.3 CH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 HH A-3 -- O H Cl CH.sub.3H A-3 -- O H Cl OCH.sub.3H A-3 -- O H SO.sub.2 CH.sub.3 CH.sub.3H A-3 -- O H SO.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 Y.sub.3 m.p.(.degree.C.)__________________________________________________________________________H A-4 -- O H CO.sub.2 CH.sub.3 CH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H HH A-4 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3H A-4 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.2 Y.sub.2 m.p.(.degree.C.)__________________________________________________________________________H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 SCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CF.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.3 m.p.(.degree.C.)__________________________________________________________________________H A-6 -- O H CO.sub.2 CH.sub.3 CH.sub.3H A-6 -- O H CO.sub.2 CH.sub.3 OCH.sub.3H A-6 -- O H NO.sub.2 CH.sub.3H A-6 -- O H NO.sub.2 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.4 Y.sub.4 m.p.(.degree.C.)__________________________________________________________________________H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 ClH A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X Y Z m.p.(.degree.C.)__________________________________________________________________________H A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CCH CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 cyclopropyl CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CN CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 SCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CN CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub. 2 H CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2 F NH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H N(CH.sub.3).sub.2 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 Cl CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 Br NH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 OCH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 cyclopropyl CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH N(CH.sub.3).sub.2 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH OCH.sub.2 CH.sub.3 CH__________________________________________________________________________
TABLE IV__________________________________________________________________________R A E W R.sub.1 R.sub.2 X Y Z m.p. (.degree.C.)__________________________________________________________________________H A-1 -- O H H CH.sub.3 CH.sub.3 CHH A-1 -- O H H CH.sub.3 OCH.sub.3 CHH A-1 -- O H H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H H CH.sub.3 CH.sub.3 NH A-1 -- O H H CH.sub.3 OCH.sub.3 NH A-1 -- O H H OCH.sub.3 OCH.sub.3 NH A-1 -- O H H Cl OCH.sub.3 CHH A-1 -- O H Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H Cl CH.sub.3 CH.sub.3 NH A-1 -- O H Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H Cl Cl OCH.sub.3 CHH A-1 -- O H Br CH.sub.3 CH.sub.3 CHH A-1 -- O H Br CH.sub.3 OCH.sub.3 CHH A-1 -- O H Br OCH.sub.3 OCH.sub.3 CHH A-1 -- O H Br CH.sub.3 CH.sub.3 NH A-1 -- O H Br CH.sub.3 OCH.sub.3 NH A-1 -- O H Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H Br Cl OCH.sub.3 CHH A-1 -- O H F CH.sub.3 CH.sub.3 CHH A-1 -- O H F CH.sub.3 OCH.sub.3 CHH A-1 -- O H F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H F CH.sub.3 CH.sub.3 NH A-1 -- O H F CH.sub.3 OCH.sub.3 NH A-1 -- O H F OCH.sub.3 OCH.sub.3 NH A-1 -- O H F Cl OCH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub. 3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(Cl)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.3 OCH.sub.3 OCH.sub. 3 CHH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(F)CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub. 3 CHH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CF.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H CF.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H CF.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CCl.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H CCl.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H CCl.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H CCl.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2 CH(F)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH(CH.sub.3)CH(Cl)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH(Cl)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH(CH.sub.3)CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 NH A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 NH A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 NH A-1 -- O H cyclopropyl Cl OCH.sub.3 CHH A-1 -- O H ##STR402## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR403## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR404## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR405## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR406## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR407## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR408## Cl OCH.sub.3 CHH A-1 -- O H ##STR409## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR410## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR411## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR412## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR413## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR414## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR415## Cl OCH.sub.3 CHH A-1 -- O H ##STR416## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR417## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR418## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR419## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR420## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR421## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR422## Cl OCH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 CH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclobutyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H cyclobutyl CH.sub.3 CH.sub.3 NH A-1 -- O H cyclobutyl CH.sub.3 OCH.sub.3 NH A-1 -- O H cyclobutyl OCH.sub. 3 OCH.sub.3 NH A-1 -- O H cyclobutyl Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CFCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CFCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CHFCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CHFCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CHFCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CHFCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CCH CH.sub. 3 OCH.sub.3 NH A-1 -- O H CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CCCH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CCCH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H CCCH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H CCCH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CH.sub.2CCCH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H CH.sub.2CCCH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 CH.sub. 3 CH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 CH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 H CH.sub.3 CH.sub.3 NH A-1 -- O H OCF.sub.2 H CH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 H OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 H Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CF.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2 CH.sub.2 Br CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br OCH.sub.3 OCH.sub. 3 NH A-1 -- O H OCH.sub.2 CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CCH Cl OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H OCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H NO.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub. 2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH(CH.sub.3 ).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub. 2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2C CH CH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 CH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 OCH.sub. 3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) OCH.sub.3 OCH.sub.3 CHH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 CH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) CH.sub.3 OCH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) OCH.sub.3 OCH.sub.3 NH A-1 -- O H NCH.sub.2 CH.sub.3 (CH.sub.3) Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHH A-1 -- O H SCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SOCH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub. 3 CHH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 NHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H SO.sub.2 N(OCH.sub.3)CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CONHCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O H CONHCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O H CONHCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CONHCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O H CON(CH.sub.2 CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O H ##STR423## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR424## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR425## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR426## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR427## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR428## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR429## Cl OCH.sub.3 CHH A-1 -- O H ##STR430## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR431## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR432## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR433## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR434## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR435## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR436## Cl OCH.sub.3 CHH A-1 -- O H ##STR437## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR438## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR439## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR440## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR441## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR442## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR443## Cl OCH.sub.3 CHH A-1 -- O H ##STR444## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR445## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR446## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR447## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR448## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR449## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR450## Cl OCH.sub.3 CHH A-1 -- O H ##STR451## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR452## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR453## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR454## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR455## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR456## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR457## Cl OCH.sub.3 CHH A-1 -- O H ##STR458## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR459## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR460## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR461## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR462## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR463## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR464## Cl OCH.sub.3 CHH A-1 -- O H ##STR465## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR466## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR467## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR468## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR469## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR470## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR471## Cl OCH.sub.3 CHH A-1 -- O H ##STR472## CH.sub.3 CH.sub.3 CHH A-1 -- O H ##STR473## CH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR474## OCH.sub.3 OCH.sub.3 CHH A-1 -- O H ##STR475## CH.sub.3 CH.sub.3 NH A-1 -- O H ##STR476## CH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR477## OCH.sub.3 OCH.sub.3 NH A-1 -- O H ##STR478## Cl OCH.sub.3 CHCH.sub. 3 A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub. 2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub. 3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CH.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H cyclopropyl Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR479## CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H ##STR480## CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR481## OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR482## CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H ##STR483## CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR484## OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR485## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR486## CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H ##STR487## CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR488## OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR489## CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H ##STR490## CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR491## OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR492## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR493## CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H ##STR494## CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR495## OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H ##STR496## CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H ##STR497## CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR498## OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H ##STR499## Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCH.sub.2 CF.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H OCF.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H NO.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub. 3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub. 2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2 CHCH.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2C CH CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H CO.sub.2 CH.sub.2CCH Cl OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O H N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-F CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-F CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-F CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 5-F CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-F CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-F CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-F CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-F CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub. 3 NH A-1 -- O 5-F CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-Cl cyclopropyl CH.sub.3 CH.sub.3 CHH A-1 -- O 5-Cl cyclopropyl CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl cyclopropyl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl cyclopropyl CH.sub.3 CH.sub.3 NH A-1 -- O 5-Cl cyclopropyl CH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl cyclopropyl OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl cyclopropyl Cl OCH.sub.3 CHH A-1 -- O 5-Cl ##STR500## CH.sub.3 CH.sub.3 CHH A-1 -- O 5-Cl ##STR501## CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl ##STR502## OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl ##STR503## CH.sub.3 CH.sub.3 NH A-1 -- O 5-Cl ##STR504## CH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl ##STR505## OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl ##STR506## Cl OCH.sub.3 CHH A-1 -- O 5-Cl ##STR507## CH.sub.3 CH.sub.3 CHH A-1 -- O 5-Cl ##STR508## CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl ##STR509## OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl ##STR510## CH.sub.3 CH.sub.3 NH A-1 -- O 5-Cl ##STR511## CH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl ##STR512## OCH.sub. 3 OCH.sub.3 NH A-1 -- O 5-Cl ##STR513## Cl OCH.sub.3 CHH A-1 -- O 5-Cl ##STR514## CH.sub.3 CH.sub.3 CHH A-1 -- O 5-Cl ##STR515## CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl ##STR516## OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-Cl ##STR517## CH.sub.3 CH.sub.3 NH A-1 -- O 5-Cl ##STR518## CH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl ##STR519## OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-Cl ##STR520## Cl OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Br CH.sub.3 CH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Br CH.sub. 3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Br OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2 CH.sub.2 Br Cl OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH CH.sub.3 CH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH CH.sub.3 CH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH CH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2CCH OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-CH.sub.3 OCH.sub.2C CH Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 NO.sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 NO.sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 NO.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 NO.sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 NO.sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 NO.sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 NO.sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub. 3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub. 3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 Cl CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 CH.sub.2 F Cl OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 5-OCH.sub. 2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 5-OCH.sub.2 CF.sub.3 CO.sub.2 CH.sub.2 OCH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 CO.sub.2 CH.sub.2 CH.sub.3 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2 Cl OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHH A-1 -- O 6-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHH A-1 -- O 6-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NH A-1 -- O 6-OCH.sub.3 SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NH A-1 -- O 6-OCH.sub.3 SO.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH.sub.2CHCH.sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH.sub.2CCH CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SCH(CH.sub.3).sub.2 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SOCH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 6-F SOCH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SOCH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SOCH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 6-F SOCH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SOCH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SOCH.sub.3 Cl OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CHCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 NCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 A-1 -- O 6-F SO.sub.2 CH.sub.3 Cl OCH.sub.3 CH__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 Y.sub.1 m.p. (.degree.C.)__________________________________________________________________________H A-2 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2H A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2H A-2 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 OH A-2 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2H A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 CH.sub.3 OH A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCH.sub.3 OH A-2 -- O H SO.sub.2 N(CH.sub.3).sub.2 OCF.sub.2 H CH.sub.2__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 m.p. (.degree.C.)__________________________________________________________________________H A-3 -- O H CO.sub.2 CH.sub.3 CH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3H A-3 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 HH A-3 -- O H Cl CH.sub.3H A-3 -- O H Cl OCH.sub.3H A-3 -- O H SO.sub.2 CH.sub.3 CH.sub.3H A-3 -- O H SO.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.1 Y.sub.3 m.p. (.degree.C.)__________________________________________________________________________H A-4 -- O H CO.sub.2 CH.sub.3 CH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 HH A-4 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H HH A-4 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-4 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3H A-4 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.2 Y.sub.2 m.p. (.degree.C.)__________________________________________________________________________H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub. 3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 SCH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3H A-5 -- O H CO.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.3 m.p. (.degree.C.)__________________________________________________________________________H A-6 -- O H CO.sub.2 CH.sub.3 CH.sub.3H A-6 -- O H CO.sub.2 CH.sub.3 OCH.sub.3H A-6 -- O H NO.sub.2 CH.sub.3H A-6 -- O H NO.sub.2 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X.sub.4 Y.sub.4 m.p. (.degree.C.)__________________________________________________________________________H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 CH.sub.3 ClH A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3H A-7 -- O H CO.sub.2 CH.sub.3 OCH.sub.2 CH.sub.3 OCH.sub.3__________________________________________________________________________R A E W R.sub.1 R.sub.2 X Y Z m.p. (.degree.C.)__________________________________________________________________________H A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 OCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CCH CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 cyclopropyl NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.3 CN CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 SCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 OCF.sub.2 H CHH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub. 2 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCH.sub.3 CN NH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H SCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H N(CH.sub.3).sub.2 NH A-1 -- O H CO.sub.2 CH.sub.3 OCF.sub.2 H NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 Cl CHH A-1 -- O H CO.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.2 Br CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H OCH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H CH.sub.2 CH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H CH.sub.2 F CHH A-1 -- O H CO.sub.2 CH.sub.3 SCF.sub.2 H NHCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 OCH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 F NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 N(CH.sub.3).sub.2 cyclopropyl NH A-1 -- O H CO.sub.2 CH.sub.3 CCH CH.sub.2 CH.sub.3 NH A-1 -- O H CO.sub.2 CH.sub.3 CCH OCH.sub.3 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH N(CH.sub.3).sub.2 CHH A-1 -- O H CO.sub.2 CH.sub.3 CCH OCH.sub.2 CH.sub.3 N__________________________________________________________________________
Formulations
Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid inert diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:
______________________________________ Active Weight Percent* Ingredient Diluent(s) Surfactant(s)______________________________________Wettable Powders 20-90 0-74 1-10Oil Suspensions, 3-50 40-95 0-15Emulsions, Solutions,(including EmulsifiableConcentrates)Aqueous Suspension 10-50 40-84 1-20Dusts 1-25 70-99 0-5Granules and Pellets 0.1-95 5-99.9 0-15High Strength 90-99 0-10 0-2Compositions______________________________________ *Active ingredient plus at least one of a Surfactant or a Diluent equals 100 weight percent.
Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.
Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, New Jersey, but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0.degree. C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, New Jersey, as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.
The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff.
For further information regarding the art of formulation, see for example: H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;
R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;
H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;
G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pp. 81-96; and
J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.
In the following Examples, all parts are by weight unless otherwise indicated.
EXAMPLE 9
______________________________________Wettable Powder______________________________________N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino- 80%carbonyl]-2-pyridinesulfonamide-1-oxidesodium alkylnaphthalenesulfonate 2%sodium ligninsulfonate 2%synthetic amorphous silica 3%kaolinite 13%______________________________________
The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged.
EXAMPLE 10
______________________________________Wettable Powder______________________________________N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3- 50%methyl-2-pyridinesulfonamide-1-oxidesodium alkylnaphthalenesulfonate 2%low viscosity methyl cellulose 2%diatomaceous earth 46%______________________________________
The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.
EXAMPLE 11
______________________________________Granule______________________________________Wettable powder of Example 10 5%attapulgite granules 95%(U.S.S. 20 to 40 mesh; 0.84-0.42 mm)______________________________________
A slurry of wettable powder containing 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.
EXAMPLE 12
______________________________________Extruded Pellet______________________________________N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino- 25%carbonyl]-2-pyridinesulfonamide-1-oxideanhydrous sodium sulfate 10%crude calcium ligninsulfonate 5%sodium alkylnaphthalenesulfonate 1%calcium/magnesium bentonite 59%______________________________________
The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.
EXAMPLE 13
______________________________________Low Strength Granule______________________________________N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3- 0.1%methyl-2-pyridinesulfonamide-1-oxideattapulgite granules 99.9%(U.S.S. 20 to 40 mesh)______________________________________
The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.
EXAMPLE 14
______________________________________Granule______________________________________N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino- 80%carbonyl]-2-pyridinesulfonamide-1-oxidewetting agent 1%crude ligninsulfonate salt (containing 10%5 to 20% of the natural sugars)attapulgite clay 9%______________________________________
The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14 to 100 mesh (1410 to 149 microns), and packaged for use.
EXAMPLE 15
______________________________________Low Strength Granule______________________________________N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3- 1%methyl-2-pyridinesulfonamide-1-oxideN,N--dimethylformamide 9%attapulgite granules 90%(U.S.S. 20 to 40 sieve)______________________________________
The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged.
EXAMPLE 16
______________________________________Aqueous Suspension______________________________________N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino- 40%carbonyl]-2-pyridinesulfonamide-1-oxidepolyacrylic acid thickener 0.3%dodecylphenol polyethylene glycol ether 0.5%disodium phosphate 1%monosodium phosphate 0.5%polyvinyl alcohol 1.0%water 56.7%______________________________________
The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size.
EXAMPLE 17
______________________________________Solution______________________________________N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3- 5%methyl-2-pyridinesulfonamide-1-oxide, ammoniumsaltwater 95%______________________________________
The salt is added directly to the water with stirring to produce the solution, which may then be packaged for use.
EXAMPLE 18
______________________________________High Strength Concentrate______________________________________N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino- 99%carbonyl]-2-pyridinesulfonamide-1-oxidesilica aerogel 0.5%synthetic amorphous silica 0.5%______________________________________
The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary.
EXAMPLE 19
______________________________________Wettable Powder______________________________________N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3- 90%methyl-2-pyridinesulfonamide-1-oxidedioctyl sodium sulfosuccinate 0.1%synthetic fine silica 9.9%______________________________________
The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged.
EXAMPLE 20
______________________________________Wettable Powder______________________________________N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino- 40%carbonyl]-2-pyridinesulfonamide-1-oxidesodium ligninsulfonate 20%montmorillonite clay 40%______________________________________
The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged.
EXAMPLE 21
______________________________________Oil Suspension______________________________________N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3- 35%methyl-2-pyridinesulfonamide-1-oxideblend of polyalcohol carboxylic 6%esters and oil soluble petroleumsulfonatesxylene 59%______________________________________
The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.
EXAMPLE 22
______________________________________Dust______________________________________N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino- 10%carbonyl]-2-pyridinesulfonamide-1-oxideattapulgite 10%Pyrophyllite 80%______________________________________
The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.
EXAMPLE 23
______________________________________Oil Suspension______________________________________N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3- 25%methyl-2-pyridinesulfonamide-1-oxidepolyoxyethylene sorbitol hexaoleate 5%highly aliphatic hydrocarbon oil 70%______________________________________
The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.
EXAMPLE 24
______________________________________Wettable Powder______________________________________N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino- 20%carbonyl]-2-pyridinesulfonamide-1-oxidesodium alkylnaphthalenesulfonate 4%sodium ligninsulfonate 4%low viscosity methyl cellulose 3%attapulgite 69%______________________________________
The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve 0.3 mm opening) and packaged.
Utility
Test results indicate that the compounds of the present invention are highly active preemergent or postemergent herbicides or plant growth regulants. Many of them have utility for broad-spectrum pre- and/or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Some of the compounds have utility for selective weed control in crops such as wheat, barley and corn. Alternatively, the subject compounds are useful to modify plant growth.
The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.01 to 10 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required.
The compounds of the invention may be used in combination with any other commercial herbicide, examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate and bipyridylium, imidazolinone types.
The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow.
______________________________________CompoundsCompound R.sub.1 R.sub.2 X Y Z______________________________________ ##STR521##1 H CH.sub.3 CH.sub.3 CH2 H CH.sub.3 OCH.sub.3 CH3 H OCH.sub.3 OCH.sub.3 CH4 H CH.sub.3 CH.sub.3 N5 H CH.sub.3 OCH.sub.3 N6 H OCH.sub.3 OCH.sub.3 N7 CH.sub.3 CH.sub.3 CH.sub.3 CH8 CH.sub.3 CH.sub.3 OCH.sub.3 CH9 CH.sub.3 OCH.sub.3 OCH.sub.3 CH10 CH.sub.3 CH.sub.3 OCH.sub.3 N11 CH.sub.3 OCH.sub.3 OCH.sub.3 N12 CH.sub.3 Cl OCH.sub.3 CH13 cyclopropyl CH.sub.3 CH.sub.3 CH14 cyclopropyl CH.sub.3 OCH.sub.3 CH15 cyclopropyl OCH.sub.3 OCH.sub.3 CH16 cyclopropyl OCH.sub.3 OCH.sub.3 N17 CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CH18 CH(CH.sub.3).sub.2 OCH.sub.3 OCH.sub.3 CH ##STR522##19 SCH.sub.3 H CH.sub.3 CH.sub.3 CH20 SCH.sub.3 H CH.sub.3 OCH.sub.3 CH21 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH22 SCH.sub.3 H CH.sub.3 OCH.sub.3 N23 SCH.sub.3 H OCH.sub.3 OCH.sub.3 N24 SCH.sub.3 H Cl OCH.sub.3 CH25 H OC.sub.2 H.sub.5 OCH.sub.3 OCH.sub.3 CH26 H OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 N27 H OC.sub.2 H.sub.5 Cl OCH.sub. 3 CH28 SCH.sub.3 SCH.sub.3 CH.sub.3 OCH.sub.3 CH ##STR523##29 CH.sub.3 OCH.sub.3 OCH.sub.3 CH30 CH.sub.3 CH.sub.3 OCH.sub.3 CH31 CH.sub.3 CH.sub.3 OCH.sub.3 N______________________________________
Test A
Seeds of crabgrass (Digitaria spp.), barnyardgrass (Echinochloa crusgalli), giant foxtail (Setaria faberi), wild oats (Avena fatua), cheatgrass (Bromus secalinus), velvetleaf (Abutilon theophrasti), morningglory (Ipomoea spp.), cocklebur (Xanthium pensylvanicum), sorghum, corn, soybean, sugarbeet, cotton, rice, wheat, barley and purple nutsedge (Cyperus rotundus) tubers were planted and treated preemergence with the test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were treated with a soil-foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table A, are based on a numerical scale extending from 0=no injury, to 10=complete kill. The accompanying descriptive symbols gave the following meanings:
C=chlorosis/necrosis;
B=burn;
D=defoliation;
E=emergence inhibition;
G=growth retardation;
H=formative effect;
U=unusual pigmentation;
X=axillary stimulation;
S=albinism; and
6Y=abscised buds or flowers.
A dash (-) response means no test. Response ratings are contained in Table A.
TABLE A CMPD 1 CMPD 2 CMPD 3 CMPD 4 CMPD 5 CMPD 6 CMPD 7 CMPD 8 CMPD 9 CMPD 10 CMPD 11 RATE = KG/HA 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 POSTEMERGENCE COTTON 0 -- 4C,9G -- 4C,9G -- 0 -- 0 -- 0 -- 3C,7H 2C 9H 2 C,8G 3C,9G 2C,9H 9H 1C 4C,9H 3C,6G MORNING GLORY 2H -- 5C,9G -- 10C -- 0 -- 0 -- 1H -- 4C,8H 2C,2H 4C,9G 2C,7G 10C 9C 5C,9G 3C,8H 5C,9G 3C,8H COCKLEBUR 0 -- 4C,9G -- 9C -- 0 -- 3C,5H -- 0 -- 4C,8G 2C,4G 8G 2C,7G 10C 7G 4C,9H 6G 6H 3G NUTSEDGE 0 -- 2C,9G -- 5C,9G -- 0 -- 0 -- 0 -- 4C,8G 0 9G 8G 4C,9G 9G 2G 0 0 0 CRABGRASS 0 -- 2G -- 2C,8G -- 0 -- 0 -- 2G -- 7G 0 8G 5G 4C,9G 3C,7G 2C,8G 3G 0 0 BARNYARD GRASS 0 -- 4C,9H -- 9C -- 0 -- 3C,8H -- 2C,8H -- 3C,9H 3C,6H 5C,9G 4C,9H 10C 4C,9H 9C 3C,7H 5C,9G 3C,7H WILD OATS -- -- -- -- -- -- -- -- -- -- -- -- 2G 0 6G 3C,6G 2C,8G 5G 3G 0 1C 0 WHEAT 0 -- 2C,3G -- 4C,9G -- 0 -- 0 -- 2G -- 7G 4G 7G 5G 4C,9G 4C,9G 9G 0 7G -- CORN 0 -- 9C -- 4C,9G -- 0 -- 3C,9H -- 4H -- 3C,7G 1C,3G 4C,9G 2C,9G 9C 3C,9G 9C 4C,9G 5C,9G 4C,9G SOYBEAN 0 -- 5C,9G -- 5C,9G -- 0 -- 2C,7G -- 2C,4G -- 3C,9H 3C,3H 5C,9G 3C,8G 5C,9G 3C,9G 5C,9G 2C,4G 5C,9G 2C,2H RICE 6G -- 9C -- 9C -- 0 -- 5C,9G -- 5C,9G -- 5C,9G 3C,8G 5C,9G 3C,9G 5C,9G 5C,9G 6C,9G 4C,9G 5C,9G 4C,9G SORGHUM 2G -- 9G -- 4C,9G -- 0 -- 3C,9H -- 3C,8H -- 4C,9G 2C,5G 3C,9G 3C,8G 3C,9G 5C,9G 5C,9G 4C,9H 4C,9G 3C,9G CHEATGRASS 0 -- 4C,8G -- 5C,9G -- 0 -- 2C,4G -- 2C,4G -- 9G 5G 9G 7G 9C 4C,9G 3C,7G 2C,5G 8G 0 SUGAR BEETS 1H -- 9C -- 9C -- 2H -- 2H -- 4H -- 4C,9G 3C,7H 10C 5C,9G 9C 9C 5C,9H 3C,5H 9C 4C,9G VELVETLEAF 0 -- 5C,9G -- 9C -- 0 -- 1C -- 1C -- 4C,9H 3C,3H 9C 4C,9G 9C 9C 4C,9H 3C,7H 4C,9H 3C,6H GIANT FOXTAIL -- -- -- -- -- -- -- -- -- -- -- -- 3C,7G 2G 4C,9G 3C,7H 5C,9G 4C,9G 3C,7G 2C,3G 0 0 BARLEY -- -- -- -- -- -- -- -- -- -- -- -- -- 5G 8G -- 9C 3C,8G 9C 2G 3G -- DOWNY BROME PREEMERGENCE COTTON -- -- -- -- -- -- -- -- -- -- -- -- 0 0 2G 0 7G 3G 2G 0 0 0 MORNING GLORY -- -- -- -- -- -- -- -- -- -- -- -- 0 0 0 0 7G 3C,3H 1H 0 0 0 COCKLEBUR -- -- -- -- -- -- -- -- -- -- -- -- 0 0 1C 0 3C,3G 2C,2H 3G 0 2G 0 NUTSEDGE -- -- -- -- -- -- -- -- -- -- -- -- -- 0 0 0 2C,3G 3G0 0 0 0 CRABGRASS -- -- -- -- -- -- -- -- -- -- -- -- 0 0 3G 0 4G 2G 0 0 0 0 BARNYARD GRASS -- -- -- -- -- -- -- -- -- -- -- -- 0 0 2G 0 3C,8H 2G 2C,3G 0 0 0 WILD OATS -- -- -- -- -- -- -- -- -- -- -- -- 0 0 0 0 3G 0 0 0 0 0 WHEAT -- -- -- -- -- -- -- -- -- -- -- -- 0 0 0 0 0 0 0 0 0 0 CORN -- -- -- -- -- -- -- -- -- -- -- -- 0 0 0 0 3C,5G 4G 0 0 0 0 SOYBEAN -- -- -- -- -- -- -- -- -- -- -- -- 2G 0 2C 0 2C,6G 2H 0 0 1C 0 RICE -- -- -- -- -- -- -- -- -- -- -- -- 2G 0 0 0 3C,8G 3G 0 0 0 0 SORGHUM -- -- -- -- -- -- -- -- -- -- -- -- 3C 0 3C 0 3C,8G 3C,5G 3G 0 3C,3G 0 CHEATGRASS -- -- -- -- -- -- -- -- -- -- -- -- 0 0 0 0 8G 5G 0 0 0 0 SUGAR BEETS -- -- -- -- -- -- -- -- -- -- -- -- 5H 0 1H 0 2C,6H 2H 5G 3G 3H 0 VELVETLEAF -- -- -- -- -- -- -- -- -- -- -- -- 2C 0 2C 0 7G 7H 2C 0 2C 0 GIANT FOXTAIL -- -- -- -- -- -- -- -- -- -- -- -- 0 0 6G 0 3C,6G 0 0 0 0 0 BARLEY -- -- -- -- -- -- -- -- -- -- -- -- 0 0 0 0 2G 0 0 0 0 0 DOWNY BROME CMPD 12 CMPD 13 CMPD 14 CMPD 15 CMPD 16 CMPD 17 CMPD 18 CMPD 19 CMPD 20 CMPD 21 RATE = KG/HA 0.05 0.01 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 POSTEMERGENCE COTTON 3C,8G 3G 2C,4G 3C,7G 6G 9G 2C,6G 3C,9H 2C,5G 4C,9G 2C,4G 2C,7H 3C,9G 5C,9G 0 0 6G 2G 2C,2G 3C,6G MORNING GLORY 4C,8G 2C,6G 1H 2C,7G 3C,6G 4C,9G 3C,8G 9C 4C,9G 9C 3C,7G 2C,8G 1C 10C 0 0 2C,3H 2C,4G 1C 3C,7G COCKLEBUR 7G 1C 2C,5G 9C 10C 4C,8H 10C 10C 9C 10C 2C,7G 3C,9H 5C,9H 10C 0 0 3C,5G 4C,9G 3C,8H 3C,9H NUTSEDGE 4C,8G -- 6G 3C,5G 7G 3C,8G 10C 9C 7G 8G 0 7G 9G 3C,9G 0 0 0 2C,8G 5G 5C,9G CRABGRASS 0 0 6G 6G 4G 6G 5G 9C 3C,7G 10C 0 2G 5G 8G 0 0 0 5G 0 4C,8G BARNYARD GRASS 3C,9H 5H 10C 5C,9H 9H 9C 10C 9C 5C,9H 10C 4C,8H 5C,9H 4C,9H 9C 0 0 0 0 0 3C,5G WILD OATS 0 0 3C,7G 4C,9G 3C,7G 2C,9G 2C,9G 5C,9G 5C,9G 9C 9G 4C,9G 3C,9G 5C,9G 0 0 0 0 0 0 WHEAT 0 0 8G 9G 8G 3C,9G 2C,9G 5C,9G 5C,9G 9C 9G 3C,9G 9G 5C,9G 0 0 0 8G 0 3G CORN 3C,7G 2G 3C,9G 3C,9G 2C,9G 9C 3C,9G 10C 9C 9C 3C,8H 8G 3C,9G 6U,9G 0 0 0 4C,9H 3C,7G 3C,9G SOYBEAN 3H 0 4C,8G 5C,9G 4C,9G 9C 5C,9G 9C 5C,9G 9C 3C,8G 5C,9G 5C,9G 5C,9G 0 0 2H 3C,8G 2C,4H 4C,9H RICE 5C,9G 3C,6G 5C,9G 9C 9G 9C 9C 9C 9C 9C 8G 5C,9G 4C,9G 5C,9G 0 0 0 3C,5G 2G 5C,9G SORGHUM 4C,9H 3C,7H 2C,9G 4C,9G 3C,9G 3C,9G 9C 9C 3C,9G 9C 3C,8H 3C,9G 3C,9G 6C,9G 0 0 3G 4C,9H 7G 3C,9H CHEATGRASS 2C,5G 0 8G 9C 3C,7G 5C,9G 9C 9C 5C,9G 9C 9G 9G 4C,9G 9C 0 0 0 2C,8G 3G 2C,9G SUGAR BEETS 9C 4C,8G 5C,9G 5C,9G 9C 5C,9G 5C,9G 10C 9C 10C 3C,8H 3C,8H 3C,8G 10C 0 0 3C,6H 10C 5C,9G 9C VELVETLEAF 8H 2C,5G 3C,9G 10C 10C 4C,9G 10C 10C 5C,9H 5C,9H 3C,8H 5C,9G 5C,9H 4C,9G 0 0 3C,5G 4C,9G 3C,7H 5C,9G GIANT FOXTAIL 2C,5G 3G 3C,5G 9G 3C,6G 2C,8G 4C,8G 9C 3C,7G 9C 0 0 3C,9G 9C 0 0 0 3C,6G 0 3C,5G BARLEY 0 0 3C,7G 2C,9G 3C,7G 3C,8G 2C,9G 5C,9G 9G 9C 7G 9G 2C,8G 3C,8G 0 0 0 0 0 0 DOWNY BROME PREEMERGENCE COTTON 5G 0 0 3G 0 3G 3G 2G 6G 0 3G 4G 9G 0 0 0 0 0 0 MORNING GLORY 3G 0 0 0 0 2G 0 2G 2C,2G 8G 0 0 0 9G 0 0 0 0 0 0 COCKLEBUR 3G -- 0 0 0 0 3G 2C,5H 1C 2C,2H 0 0 8G 9H 0 0 0 1C 0 3C NUTSEDGE 0 0 0 0 0 0 9G 10E 0 0 0 0 5G 10E 0 0 0 0 0 0 CRABGRASS 0 0 0 0 0 0 2G 3C,6G 0 3C,5G 0 0 7G 8G 0 0 0 0 0 0 BARNYARD GRASS 3G 0 0 2G 0 2G 3G 9H 0 3C,8G 0 0 3C,8H 9H 0 0 0 0 0 0 WILD OATS 0 0 0 3G 0 2G 7G 3C,8G 0 3C,6G 0 0 3G 8G 0 0 0 0 0 0 WHEAT 0 0 0 5G 0 3G 8G 2C,8H 3G 8G 0 0 8G 9G 0 0 0 0 0 0 CORN 3G 0 0 2C,4G 0 3C,4G 3C,6G 3C,9G 3C,5G 3C,7G 0 2C,3G 3C,8H 9G 0 0 0 0 0 2C,3G SOYBEAN 2G 0 0 3C,4H 0 1C 3C,7G 3C,8G 2C,4G 4C,8G 0 1C 1C,3G 4C,8H 0 0 0 0 0 2C RICE 6G 0 0 3C,7G 0 0 9H 10H 3G 4C,9G 0 2C 2C,8G 10H 0 0 0 0 0 0 SORGHUM 3C,6G 0 0 3C,5G 0 2C,3G 3C,9H 9H 3C,5G 3C,9G 0 1C,2G 9G 5C,9H 0 0 0 0 2C 2C,4G CHEATGRASS 0 0 0 6G 0 3G 7G 9H 0 3C,8G 0 0 7G 4C,9H 0 0 0 0 0 0 SUGAR BEETS 0 0 0 2H 0 4G 8G 9G 5G 3C,6G 0 1C,3G 2G 9G 0 0 0 2G 2H 3H VELVETLEAF 2G 0 0 7H 4G 3H 8G 4C,9G 0 2C,5H 0 2C,3H 8G 4C,9G 0 0 0 0 0 0 GIANT FOXTAIL 0 0 0 0 0 0 7G 9H 0 2C,2G 0 0 2C,8G 3C,9G 0 0 0 0 0 0 BARLEY 0 0 0 2G 0 0 6G 3C,8G 2C,2G 8G 0 3G 9G 9G 0 0 0 0 0 0 DOWNY BROME CMPD 22 CMPD 23 CMPD 24 CMPD 25 CMPD 26 CMPD 27 CMPD 28 CMPD 29 CMPD 30 CMPD 31 RATE = KG/HA 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 POSTEMERGENCE COTTON 0 0 0 3C,4G 0 0 2G 5C,9G 0 3C,5G 4G 3C,6G 0 0 0 0 0 0 0 0 MORNING GLORY 0 3C,6G 0 1H 0 0 9C 10C 3C,6G 4C,8G 3C,5G 5C,9G 2C,5G 3C,8H 0 0 0 0 2H 3H COCKLEBUR 3H 3C,8G 2H 3C,8H 0 3G 3C,9G 10C 7G 4C,8H 4G 4C,9G 3C,8H 5C,9G 0 0 0 0 0 0 NUTSEDGE 0 0 0 0 0 0 10C 10C 0 0 4G 5C,9G 3G 0 0 0 0 0 0 CRABGRASS 0 0 0 2G 0 0 3C,7G 0 4C,8G 3G 3C,6G 0 3G 0 0 0 0 0 0 BARNYARD GRASS 0 3G 0 2G 0 0 5C,9G 10C 3C,9H 10C 3C,7H 5C,9G 0 3C,7H 0 0 0 0 0 0 WILD OATS 0 0 0 0 0 0 3C,9G 5C,9G 3C,5G 5C,9G 0 5 0 3G 0 0 0 0 0 0 WHEAT 0 0 0 0 0 0 8G 5C,9G 3C,6G 4C,9G 0 5G 0 3G 0 0 0 0 0 0 CORN 0 4G 0 0 0 3G 9C 10C 9C 9C 9G 9C 0 3C,9G 0 0 0 0 0 0 SOYBEAN 0 3C,3H 0 3C,4H 0 0 9C 5C,9G 3C,8G 5C,9G 5G 4C,9G 1H 3C,7H 0 0 0 0 0 0 RICE 0 3C,4G 0 4G 0 0 4C,9G 5C,9G 9C 5C,9G 4C,9G 5C,9G 0 8G 0 0 0 0 0 0 SORGHUM 0 3C,7G 0 2G 0 4G 9C 10C 5C,9G 9C 4C,9G 5C,9G 2G 3C,9G 0 2G 0 0 0 0 CHEATGRASS 0 0 0 0 0 0 3G 2G SUGAR BEETS 3C,4G 9C 0 5C,9G 0 3C,8H 9C 5C,9G 4C,9H 4C,8H 3C,8G 9C 3C,5G 9C 0 9C 0 0 0 0 VELVETLEAF 0 3C,6G 0 3C,8G 0 0 5C,9G 9C 0 3C,6G 3C,7G 9C 2G 4C,9G 2G 10C 0 0 0 0 GIANT FOXTAIL 0 0 0 3G 0 0 9C 9C 0 0 0 0 0 2G 0 0 0 0 0 0 BARLEY 0 0 0 0 0 0 4C,9G 9C 7G 4C,9G 3G 5G 0 3G 0 0 0 0 0 0 DOWNY BROME 4C,9G 3C,9G 7G 3C,5G 0 7G 0 5G 0 0 0 0 PREEMERGENCE COTTON 0 0 0 0 0 0 0 7G 0 0 5G 5G 0 0 0 0 0 0 0 0 MORNING GLORY 0 0 0 0 0 0 7G 9G 0 0 3G 8G 0 0 0 0 0 0 0 0 COCKLEBUR 0 0 0 0 0 0 6G 3C,8H 0 0 1H 3C,7G 0 0 0 0 0 0 0 0 NUTSEDGE 0 0 0 0 0 0 10E 10E 0 0 0 9G 0 0 0 0 0 0 0 0 CRABGRASS 0 0 0 0 0 0 3C,6G 3C,9G 0 2G 2G 3C,7G 0 0 0 0 0 0 0 0 BARNYARD GRASS 0 0 0 0 0 0 3C,5G 9H 0 3C,7H 2C 7G 0 0 0 0 0 0 0 0 WILD OATS 0 0 0 0 0 0 3C,3G 3C,8H 0 0 0 0 0 0 0 0 0 0 0 0 WHEAT 0 0 0 0 0 0 2C,6G 9H 0 0 0 0 0 0 0 0 0 0 0 0 CORN 0 0 0 0 0 0 3C,7H 3C,9G 0 0 2G 3C,8G 0 0 0 0 0 0 0 0 SOYBEAN 0 0 0 0 0 0 3C,8G 3C,8H 0 0 2G 3C,6H 0 0 0 0 0 0 0 0 RICE 0 0 0 0 0 0 8H 9H 0 0 3G 9H 0 0 0 0 0 0 0 0 SORGHUM 0 0 0 0 0 0 3C,8H 10H 0 3C,8H 5G 3C,9G 0 0 0 0 0 0 0 0 CHEATGRASS 0 0 0 0 0 0 0 0 SUGAR BEETS 0 0 0 0 0 0 8G 7G 0 2H 4G 5G 0 0 0 0 0 0 0 0 VELVETLEAF 0 0 0 0 0 0 6H 3C,9G 0 0 0 2C,4H 0 0 0 0 0 0 0 0 GIANT FOXTAIL 0 0 0 0 0 0 3C,5G 3C,9H 0 0 0 2G 0 0 0 0 0 0 0 0 BARLEY 0 0 0 0 0 0 3C,6G 2C,8G 0 0 0 2G 0 0 0 0 0 0 0 0 DOWNY BROME 8G 3C,8H 0 0 2G 5G 0 0 0 0 0 0
Test B
Postemergence
Three round pans (25 cm diameter by 12.5 cm deep) were filled with Sassafras sandy loam soil. One pan was planted with nutsedge (Cyperus rotundus) tubers, crabgrass (Digitaria sanguinalis), sicklepod (Cassia obtusifolia), jimsonweed (Datura stramonium), velvetleaf (Abutilon theophrasti), lambsquarters (Chenopodium album), rice (Oryza sativa) and teaweed (Sida spinosa). The second pot was planted with green foxtail (Setaria viridis), cocklebur (Xanthium pensylvanicum), morningglory (Ipomoea hederacea), cotton (Gossypium hirsutum), johnsongrass (Sorghum halepense), barnyardgrass (Echinochloa crusgalli), corn (Zea mays), soybean (Glycine max) and giant foxtail (Setaria faberia). The third pot was planted with wheat (Triticum aestivum), barley (Hordeum vulgare), wild buckwheat (Polgonum convolvulus L.), cheatgrass (Bromus secalinus L.), sugarbeet (Beta vulgaris), wild oat (Avena fatua), viola (Viola arvensis), blackgrass (Alpercurus myosuroides), and rape (Brassica napus). The plants were grown for approximately fourteen days, then sprayed postemergence with the chemicals dissolved in a non-phytotoxic solvent.
Preemergence
Three round pans (25 cm diameter by 12.5 cm deep) were filled with Sassafras sandy loam soil. One pan was planted with nutsedge tubers, crabgrass, sicklepod, jimsonweed, velvetleaf, lambsquarters, rice and teaweed. The second pot was planted with green foxtail, cocklebur, morningglory, cotton, johnsongrass, barnyardgrass, corn, soybean and giant foxtail. The third pot was planted with wheat, barley, wild buckwheat, cheatgrass, sugarbeet, wild oat, viola, blackgrass and rape. The three pans were sprayed preemergence with the chemicals dissolved in a non-phytotoxic solvent.
Treated plants and controls were maintained in the greenhouse for 24 days, then all rated plants were compared to controls and visually rated for plant response.
Response ratings are based on a scale of 0 to 100 where 0=no effect and 100=complete control. A dash (-) response means no test.
Response ratings are contained in Table B.
TABLE B CMPD 2 CMPD 3 CMPD 9 CMPD 10 CMPD 15 CMPD 16 CMPD 18 RATE = G/HA 1. 4. 16. 62. 250. 0250 0062 0016 0004 0016 0016 0004 0004 0016 0062 0004 0016 0062 0001 0004 0016 0062 PREEMERGENCE GIANT FOXTAIL -- -- 50 90 100 90 80 0 0 0 0 0 50 80 0 30 VELVETLEAF -- -- 30 90 90 90 90 80 0 40 0 0 60 90 100 30 50 70 20 80 100 100 SUGAR BEETS -- -- 0 70 90 90 -- 50 30 70 0 0 90 100 30 70 30 70 100 100 CRABGRASS -- -- 20 50 90 50 70 80 0 30 60 0 20 70 80 TEAWEED -- -- 0 40 90 90 0 0 0 0 0 0 50 70 80 0 30 60 50 60 80 100 JIMSONWEED -- -- 0 40 80 90 0 0 0 0 0 0 30 50 90 0 30 50 0 20 40 80 RICE -- -- 60 90 100 100 70 50 30 40 0 0 90 100 100 30 50 80 40 80 80 100 COCKLEBUR -- -- 0 0 20 80 40 40 0 30 20 0 30 60 70 0 30 50 0 30 50 80 COTTON -- -- 0 20 60 90 70 20 0 0 0 0 0 20 30 0 0 30 20 30 50 100 SOYBEAN -- -- 0 10 80 80 50 30 0 20 0 0 30 50 0 0 0 20 40 70 BARNYARD -- -- 20 50 90 90 40 20 0 0 0 0 0 30 70 0 30 60 30 40 100 100GRASS WILD OATS -- -- 0 0 40 50 40 0 0 0 0 0 30 50 0 30 20 40 70 90 MORNINGGLORY -- -- 0 0 50 80 50 20 20 20 20 0 0 30 50 0 0 30 0 0 20 50 WHEAT -- -- 0 0 0 30 0 0 0 0 0 0 30 60 0 30 20 40 80 90 CASSIA -- -- 0 80 90 80 90 100 50 100 30 70 100 JOHNSONGRASS -- -- 20 80 90 80 70 30 0 0 0 0 60 90 100 50 70 80 30 50 70 80 NUTSEDGE -- -- 20 70 90 90 60 0 0 0 0 0 30 50 100 0 0 30 0 0 30 90 CORN -- -- 0 10 80 50 20 0 0 0 0 0 0 60 0 30 0 20 100 100 WILD -- -- -- -- -- 50 70 30 50 20 80 90 100 BUCKWHEAT BLACK GRASS -- -- 30 80 90 80 50 0 0 0 0 0 80 90 50 70 40 60 80 80 RAPESEED -- -- 0 0 80 90 70 30 0 0 0 0 50 70 30 50 30 70 100 100 BARLEY -- -- -- -- -- 30 0 0 0 0 0 0 30 60 0 30 20 40 70 80 GREEN FOXTAIL -- -- -- -- -- 90 70 30 0 0 0 0 30 70 100 0 30 50 30 50 100 100 CHEAT GRASS -- -- -- -- -- 80 70 0 0 20 0 0 70 90 50 70 70 80 90 90 BUCKWHEAT -- -- -- -- -- VIOLA -- -- -- -- -- 90 80 0 0 20 0 0 LAMBSQUARTER -- -- -- -- -- 100 70 60 0 70 0 0 100 100 100 50 80 90 20 60 70 100 CHICK WEED 70 80 50 70 90 90 RATE = G/HA 1. 4. 16. 62. 250. 1. 4. 16. 62. 250. 0250 0062 0016 0004 0062 0016 0004 0001 0004 0016 0062 0001 0004 0016 00620001 00040016 0062 POSTEMERGENCE GIANT FOXTAIL -- 0 0 0.0 50 0 0 0 40 -- 100 80 70 50 90 30 20 20 40 60 90 0 0 50 90 20 30 80 100 VELVETLEAF -- 20 70 100.30 90 0 30 90 100 -- 100 100 100 80 90 70 40 60 80 90 100 30 80 90 100 30 60 100 100 SUGAR BEETS -- 50 100 100.0 50 50 90 100 100 -- 100 100 100 60 80 80 70 0 70 100 100 0 50 100 100 20 40 70 80 CRABGRASS -- 0 0 30.20 40 0 0 0 30 -- 0 20 40 60 20 40 80 100 20 40 70 80 TEAWEED -- 0 40 80.20 50 0 0 40 70 -- 90 80 50 50 70 60 40 20 40 60 90 0 40 80 90 20 40 80 100 JIMSONWEED -- 20 70 80.0 60 0 0 30 70 -- 100 90 70 60 100 70 50 30 40 60 100 0 30 50 70 20 40 70 90 RICE -- 20 80 100.50 90 20 50 100 100 -- 100 100 100 50 100 90 90 60 90 90 100 80 90 100 100 50 80 100 100 COCKLEBUR -- 0 0 0.0 0 0 0 20 90 -- 100 50 30 20 70 30 0 30 50 100 100 30 80 100 100 0 50 100 100 COTTON -- 30 40 100.0 0 0 20 60 100 -- 80 70 70 20 50 20 0 0 0 20 30 0 30 40 90 20 50 SOYBEAN -- 30 90 100.0 40 0 50 100 100 -- 100 90 80 50 90 50 50 40 90 100 100 50 80 100 100 40 100 100 100 BARNYARD -- 0 0 30.0 0 0 0 30 60 -- 100 90 80 60 100 70 30 70 90 100 100 40 90 100 100 60 90 100 100 GRASS WILD OATS -- 0 0 0.0 0 0 0 0 30 -- 90 70 40 30 40 30 0 40 90 90 100 30 90 100 100 70 90 90 MORNINGGLORY -- 0 50 100.0 50 0 20 60 80 -- 100 100 90 30 80 30 30 0 40 90 90 0 60 90 100 0 20 80 100 WHEAT -- 0 0 0.0 0 0 0 0 0 -- 60 40 10 0 10 0 0 40 50 70 100 40 50 90 100 50 80 100 100 CASSIA -- 20 80 100.50 80 0 30 80 100 -- 50 90 100 100 30 85 90 100 40 90 100 100 JOHNSONGRASS -- 0 0 40.40 80 0 30 80 100 -- 100 80 50 30 60 50 20 50 85 100 100 30 60 90 100 30 90 100 100 NUTSEDGE -- 0 0 20.20 50 0 0 40 100 -- 100 80 60 30 0 0 0 40 90 100 100 0 0 20 40 20 100 100 100 CORN -- 50 100 100.0 30 30 90 100 100 -- 100 90 80 60 80 60 20 80 90 100 100 90 100 100 100 80 90 100 100 WILD -- -- -- -- -- -- -- -- -- -- 30 50 90 100 30 80 100 100 30 40 100 100 BUCKWHEAT BLACK GRASS -- 0 0 0.50 80 0 0 0 40 -- 80 70 40 40 30 0 0 40 90 100 100 40 70 100 100 60 100 100 RAPESEED -- 50 90 100.0 80 50 70 100 100 -- 100 100 100 100 100 100 70 60 100 100 100 60 100 100 100 100 100 100 BARLEY -- -- -- -- -- -- -- -- -- -- 70 60 10 0 10 10 0 50 60 80 100 40 90 100 100 40 80 90 100 GREEN FOXTAIL -- -- -- -- -- -- -- -- -- -- 100 100 80 70 90 80 40 40 60 80 90 0 40 80 90 30 50 100 100 CHEAT GRASS -- -- -- -- -- -- -- -- -- -- 90 80 70 60 60 50 40 30 50 90 100 0 40 90 100 50 70 100 100 BUCKWHEAT -- -- -- -- -- -- -- -- -- -- VIOLA -- -- -- -- -- -- -- -- -- -- -- -- -- 0 -- -- 70 LAMBSQUARTER -- -- -- -- -- -- -- -- -- -- 100 100 100 100 100 90 80 40 100 100 0 50 70 90 30 60 80 100 CHICK WEED 0 30 80 100 30 70 90 100 50 70 80
Claims
  • 1. A compound of the formula: ##STR524## wherein J is ##STR525## wherein R is H or CH.sub.3 ;
  • E is a single bond or CH.sub.2 ;
  • W is O, S or NR.sub.x ;
  • R.sub.x is H, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy;
  • R.sub.1 is H, F, Cl, Br, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkoxy or C.sub.1 -C.sub.3 thioalkyl;
  • R.sub.2 is H, Cl, Br, F, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, cyclopropyl optionally substituted by 1-4 halogen, cyclobutyl optionally substituted by 1-4 halogen, C.sub.2 -C.sub.4 alkenyl optionally substituted by halogen, C.sub.2 -C.sub.4 alkynyl optionally substituted by halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, NO.sub.2, CO.sub.2 R.sub.3, NR.sub.4 R.sub.5, S(O).sub.n R.sub.6, SO.sub.2 NR.sub.7 R.sub.8, C(O)NR.sub.9 R.sub.10, ##STR526## n is 0, 1 or 2; R.sub.3 is C.sub.1 -C.sub.3 alkyl, C.sub.2 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.3 -C.sub.4 alkenyl, CH.sub.2 (C.sub.3 -C.sub.5 cycloalkyl) or C.sub.3 -C.sub.4 alkynyl;
  • R.sub.4 is H or C.sub.1 -C.sub.2 alkyl;
  • R.sub.5 is C.sub.1 -C.sub.2 alkyl;
  • R.sub.6 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkoxyalkyl or C.sub.1 -C.sub.3 haloalkyl;
  • R.sub.7 is H or C.sub.1 -C.sub.2 alkyl;
  • R.sub.8 is C.sub.1 -C.sub.2 alkyl or C.sub.1 -C.sub.2 alkoxy;
  • R.sub.9 is H or C.sub.1 -C.sub.3 alkyl;
  • R.sub.10 is C.sub.1 -C.sub.3 alkyl;
  • R.sub.11 is H or CH.sub.3 ;
  • R.sub.12 is H or CH.sub.3 ;
  • R.sub.13 is H, C.sub.1 -C.sub.3 alkyl, allyl, C.sub.1 -C.sub.3 haloalkyl or C.sub.1 -C.sub.3 alkyl substituted with C.sub.1 -C.sub.2 alkoxy;
  • R.sub.13 ' is H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, allyl, C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 haloalkoxy or C.sub.1 -C.sub.2 alkylthio;
  • R.sub.13 " is H, C.sub.1 -C.sub.3 alkyl, allyl or C.sub.1 -C.sub.3 haloalkyl;
  • R.sub.14 is C.sub.1 -C.sub.3 alkyl, CH.sub.2 OCH.sub.3 or CH.sub.2 CN; ##STR527## X is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, halogen, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy, amino, C.sub.1 -C.sub.3 alkylamino or di(C.sub.1 -C.sub.3 alkyl)amino;
  • Y is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylthio, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkoxyalkoxy, amino, C.sub.1 -C.sub.3 alkylamino, di(C.sub.1 -C.sub.3 alkyl)amino, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, C.sub.2 -C.sub.5 alkylthioalkyl, C.sub.2 -C.sub.5 alkylsulfinylalkyl, C.sub.2 -C.sub.5 alkylsulfonylalkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.4 alkynyl, C.sub.3 -C.sub.5 cycloalkyl, azido, cyano, ##STR528## or N(OCH.sub.3)CH.sub.3 ;
  • m is 2 or 3;
  • Q.sub.1 and Q.sub.2 are independently O or S;
  • R.sub.a is H or C.sub.1 -C.sub.3 alkyl;
  • R.sub.b and R.sub.c are independently C.sub.1 -C.sub.3 alkyl; and
  • Z is CH, CCH.sub.3, CC.sub.2 H.sub.5, CCl or CBr;
  • and their agriculturally suitable salts; provided that
  • (1) when X is halogen, then Z is CH and Y is OCH.sub.3, OC.sub.2 H.sub.5, NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2, OCF.sub.2 H, OCF.sub.2 Br or N(OCH.sub.3)CH.sub.3 ;
  • (2) when W is S, then R is H, E is a single bond, Z is CH and Y is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5, CHHd 2OCH.sub.3, C.sub.2 H.sub.5, CF.sub.3, SCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2, OCH.sub.2 .tbd.CH, OCH.sub.2 CH.sub.2 OCH.sub.3, CH(OCH.sub.3).sub.2 or ##STR529## nd (3) when the total number of carbon atoms of X and Y is greater than four, then the combined number of carbons of R.sub.1 and R.sub.2 is less than or equal to six and
  • (4) when X or Y is C.sub.1 haloalkoxy, then Z is CH.
  • 2. A compound of claim 1 where
  • X is C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, Cl, F, Br, I, OCF.sub.2 H, CH.sub.2 F, CF.sub.3, OCH.sub.2 CH.sub.2 F, OCH.sub.2 CHF.sub.2, OCH.sub.2 CF.sub.3, CH.sub.2 Cl or CH.sub.2 Br; and
  • Y is H, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, CH.sub.2 OCH.sub.3, CH.sub.2 OCH.sub.2 CH.sub.3, NHCH.sub.3, N(OCH.sub.3)CH.sub.3, N(CH.sub.3).sub.2, CF.sub.3, SCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2, OCH.sub.2 C.tbd.CH, OCH.sub.2 CH.sub.2 OCH.sub.3, CH.sub.2 SCH.sub.3, C(O)R.sub.a, ##STR530## OCF.sub.2 H, SCF.sub.2 H, OCF.sub.2 Br, cyclopropyl, C.tbd.CH or C.tbd.CCH.sub.3 ;
  • Z is CH; and
  • R.sub.a is H or CH.sub.3.
  • 3. A compound of claim 2 where
  • E is a single bond;
  • W is O; and
  • R.sub.1 is H, F, Cl, Br, CH.sub.3, C.sub.1 haloalkyl or OCH.sub.3.
  • 4. A compound of claim 2 where
  • E is CH.sub.2 ;
  • W is O; and
  • R.sub.1 is H, F, Cl, Br, CH.sub.3 or OCH.sub.3.
  • 5. A compound of claim 3 where
  • R.sub.2 is H, Cl, Br, F, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 haloalkyl, cyclopropyl, C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 haloalkoxy, CF.dbd.CFCl, CF.dbd.CFCF.sub.3, NO.sub.2, CO.sub.2 R.sub.3, NR.sub.4 R.sub.5, S(O).sub.n R.sub.6, SO.sub.2 NR.sub.7 R.sub.8, SO.sub.2 N(OCH.sub.3)CH.sub.3, C(O)NR.sub.9 R.sub.10, R.sub.2 -A, R.sub.2 -B, R.sub.2 -E, R.sub.2 -J, R.sub.2 -N, R.sub.2 -Q, R.sub.2 -R, R.sub.2 -X, R.sub.2 -Y, R.sub.2 -AB, R.sub.2 -AC or R.sub.2 -AD;
  • R.sub.3 is CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 OCH.sub.3 or CH.sub.2 CH.sub.2 Cl;
  • R.sub.4 is H or CH.sub.3 ;
  • R.sub.6 is C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl or allyl;
  • R.sub.7 is H or CH.sub.3 ;
  • R.sub.8 is C.sub.1 -C.sub.2 alkyl
  • R.sub.9 is H or CH.sub.3 ;
  • R.sub.10 is CH.sub.3 or CH.sub.2 CH.sub.3 ;
  • R.sub.13 is H, CH.sub.3, CH.sub.2 CH.sub.3 or CH.sub.2 CH.sub.2 OCH.sub.3 ; and
  • R.sub.13 " is H, CH.sub.3 or CH.sub.2 CH.sub.3.
  • 6. A compound of claim 5 where
  • X is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, Cl, OCF.sub.2 H or OCH.sub.2 CF.sub.3 ;
  • Y is CH.sub.3, OCH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 OCH.sub.3, NHCH.sub.3 or CH(OCH.sub.3).sub.2.
  • 7. A compound of claim 6 where J is J-1.
  • 8. A compound of claim 6 where J is J-2.
  • 9. A compound of claim 6 where J is J-3.
  • 10. A compound of claim 6 where J is J-4.
  • 11. The compound of claim 1 which is N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide.
  • 12. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 1 and at least one of the following: surfactant, solid or liquid diluent.
  • 13. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 2 and at least one of the following: surfactant, solid or liquid diluent.
  • 14. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 3 and at least one of the following: surfactant, solid or liquid diluent.
  • 15. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 4 and at least one of the following: surfactant, solid or liquid diluent.
  • 16. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 5 and at least one of the following: surfactant, solid or liquid diluent.
  • 17. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 6 and at least one of the following: surfactant, solid or liquid diluent.
  • 18. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 11 and at least one of the following: surfactant, solid or liquid diluent.
  • 19. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim 1.
  • 20. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim 2.
  • 21. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim 3.
  • 22. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim 4.
  • 23. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim 5.
  • 24. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim 6.
  • 25. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim 11.
RELATED APPLICATION

This application is a continuation-in-part of copending application U.S. Ser. No. 929,980, filed Nov. 12, 1986, abandoned.

US Referenced Citations (9)
Number Name Date Kind
4339267 Levitt Jul 1982
4342587 Levitt Aug 1982
4421550 Selby et al. Dec 1983
4425155 Dumas Jan 1984
4435206 Levitt Mar 1984
4456469 Adams, Jr. Jun 1984
4487626 Zimmerman Dec 1984
4496392 Levitt Jan 1985
4579583 Fory et al. Apr 1986
Foreign Referenced Citations (10)
Number Date Country
13480 Jul 1980 EPX
84224 Jul 1983 EPX
125864 Nov 1984 EPX
155767 Sep 1985 EPX
161905 Nov 1985 EPX
164269 Dec 1985 EPX
171286 Feb 1986 EPX
187489 Jul 1986 EPX
201345 Nov 1986 EPX
870436 Jul 1987 ZAX
Continuations (1)
Number Date Country
Parent 929980 Nov 1986