Herbicidal sulfonamides

BACKGROUND OF THE INVENTION
This invention relates to a herbicidally active sulfonamide, agriculturally suitable compositions thereof and a method of using it to control the growth of undesired vegetation.
New compounds effective for controlling the growth of undesired vegetation are in constant demand. In the most common situation, such compounds are sought to selectively control the growth of weeds in useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides are desired which will control all plant growth. Examples of areas in which complete control of all vegetation is desired are areas around fuel storage tanks, ammunition depots and industrial storage areas. There are many products commercially available for these purposes, but the search continues for products which are more effective, less costly and environmentally safe.
The "sulfonylurea" herbicides are an extremely potent class of herbicides discovered within the last few years. A multitude of structural variations exist within this class of herbicides, but they generally consist of a sulfonylurea bridge, --SO.sub.2 NHCONH--, linking two aromatic or heteroaromatic rings.
U.S. Pat. No. 4,394,506 discloses herbicidal orthoalkoxycarbonylbenzenesulfonamides such as ##STR1## wherein
R.sub.2 is H, F, Cl, Br, C.sub.2 -C.sub.3 alkyl, NO.sub.2, SO.sub.2 CH.sub.3, OCH.sub.3, SCH.sub.3, CF.sub.3, N(CH.sub.3).sub.2, NH.sub.2 or CN;
X is H, Cl, CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3 or OCH.sub.2 CH.sub.2 OCH.sub.3 ; and
X is H, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 substituted alkyl, C.sub.1 -C.sub.4 alkoxy, alkylamino, dialkylamino, etc.
South African patent application No. 81/4874 discloses herbicidal sulfonamides of formula ##STR2## wherein
A is a C.sub.1 -C.sub.6 alkyl radical which is substituted by halogen or various other organic substituents of a C.sub.2 -C.sub.6 alkenyl radical which is substituted or unsubstituted.
X is O, S, SO or SO.sub.2 ;
R.sub.1 is H, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl or YR.sub.5 ;
R.sub.2 is H, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.1 -C.sub.4 haloalkyl, CO.sub.2 R.sub.6, YR.sub.5, NO.sub.2 or CONR.sub.7 R.sub.8 ; and
R.sub.3 and R.sub.4, each independently of the other, are hydrogen, C.sub.1 -C.sub.4 arkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkyl, halogen or alkoxyalkyl of at most 4 carbon atoms.
South African patent application No. 85/5042 discloses herbicidal sulfonamides of formula ##STR3## wherein
A is C.sub.3 -C.sub.6 alkynyl;
X is O, S, SO or SO.sub.2 ;
R.sub.1 is H, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl or YR.sub.5 ;
R.sub.2 is H, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkenyl, C.sub.1 -C.sub.4 haloalkyl, CO.sub.2 R.sub.6, YR.sub.5, NO.sub.2 or CONR.sub.7 R.sub.8 ; and
R.sub.3 and R.sub.4, independently of one another, are hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy, halogen or alkoxyalkyl or at most 4 carbon atoms.
South African patent application No. 82/5671 discloses herbicidal sulfonamides of formula ##STR4## wherein
A is a C.sub.1 -C.sub.6 alkyl radical or a C.sub.2 -C.sub.6 alkenyl radical which is substituted by halogen or various other organic substituents;
X is O, S, SO or SO.sub.2 ;
R.sub.1 is H, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl or YR.sub.5 ;
R.sub.2 is H, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.1 -C.sub.4 haloalkyl, CO.sub.2 R.sub.6, YR.sub.5, NO.sub.2 or CONR.sub.7 R.sub.8 ;
R.sub.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy, halogen or alkoxyalkyl or at most 4 carbon atoms; and
R.sub.4 is C.sub.1 -C.sub.4 haloalkoxy or C.sub.1 -C.sub.4 haloalkylthio.
South African patent application No. 82/7439 discloses herbicidal sulfonamides of formula ##STR5## wherein
A is a C.sub.3 -C.sub.6 alkynyl group, a C.sub.1 -C.sub.6 alkyl group which is substituted by halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 haloalkylsulfinyl or C.sub.1 -C.sub.4 haloalkylsulfonyl, or it is a C.sub.2 -C.sub.6 or alkenyl group substituted by one of the above substituents;
X is O, S, SO or SO.sub.2 ;
R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl or a YR.sub.6 group;
R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.1 -C.sub.4 haloalkyl, YR.sub.6, CO.sub.2 R.sub.7, NO.sub.2 of CONR.sub.8 R.sub.9 ;
R.sub.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy, halogen, or alkoxyalkyl having at most 4 carbon atoms;
R.sub.4 is hydrogen, methyl or ethyl;
R.sub.5 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy, methoxymethyl, cyanomethyl or cyanoethyl;
R.sub.6 and R.sub.7 are each C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl or C.sub.2 -C.sub.6 alkynyl;
South African patent application No. 83/0441 (Swiss priority 1/25/82) discloses herbicidal benzenesulfonamides of formula ##STR6## wherein
R.sub.1 is H, halogen, NO.sub.2, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.5 alkenyl or C.sub.1 -C.sub.4 alkoxycarbonyl;
R.sub.2 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, each unsubstituted or substituted by 1 to 3 halogen atoms;
R.sub.3 is halogen, H, NR.sub.4 R.sub.5, C.sub.1 -C.sub.3 alkyl, unsubstituted or substituted by 1 to 3 halogen atoms or C.sub.1 -C.sub.4 alkoxy, or is C.sub.1 -C.sub.3 alkoxy, unsubstituted or substituted by methoxy, ethoxy, or 1 to 3 halogen atoms;
A is C.sub.1 -C.sub.4 alkylene or C.sub.2 -C.sub.4 alkenylene, each unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl;
m is 0 or 1;
E is N or CH;
X is oxygen, sulfur, SO or SO.sub.2 ; and
Q is, in part, OH, CN, NR.sub.6 R.sub.7, SO.sub.2 R.sub.8, cycloalkyl or COC.sub.1 -C.sub.6 alkyl.
South African patent application No. 83/3779 (Swiss priority 5/26/82) discloses herbicidal benzenesulfonamides of formula ##STR7## wherein
A is C.tbd.CR;
m is 1 or 2;
E is CH or N;
Z is oxygen or sulfur,
R is, in part, H, C.sub.1 -C.sub.9 alkyl or C.sub.1 -C.sub.9 haloalkyl;
R.sub.1 is H, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl or YR.sub.5 ;
R.sub.2 is H, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.1 -C.sub.4 haloalkyl, YR.sub.5, CO.sub.2 R.sub.6, NO.sub.2 or CONR.sub.7 R.sub.8 ;
R.sub.3 and R.sub.4, each independently of the other, are H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkylthio, halogen C.sub.2 -C.sub.5 alkoxy alkyl, NR.sub.9 R.sub.10 or OCH.sub.2 CH.sub.2 NR.sub.9 R.sub.10.
South African patent application No. 83/6449 (Swiss priority 9/1/82) discloses herbicidal benzenesulfonamides of formula ##STR8## wherein
R.sub.1 is H, halogen, NO.sub.2, amino, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.4 haloalkyl or a QR.sub.7, CO.sub.2 R.sub.8 or (CO).sub.n NR.sub.9 R.sub.10 radical;
R.sub.2 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkxoy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy, halogen or alkoxyalkyl containing not more than 4 carbon atoms;
R.sub.3 is C.sub.2 -C.sub.10 alkenyl which is substituted by one or more fluorine or bromine atoms or by one or more hydroxyl, cyano, nitro, (Y).sub.m CO(Z).sub.n R.sub.8, SO.sub.2 NR.sub.11 R.sub.12, S(O).sub.p C.sub.1 -C.sub.3 haloalkyl or S(O).sub.n C.sub.1 -C.sub.3 alkyl groups and which may additionally be substituted by one or more chlorine atoms;
R.sub.4 is C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 haloalkoxy;
R.sub.5 is H, halogen, NR.sub.13 R.sub.14, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.2 haloalkoxy; and
E is CH or N.
South African patent application No. 84/2245 (Swiss priority 3/28/83) discloses herbicidal sulfonamides of formula ##STR9## wherein
A is C.sub.1 -C.sub.6 haloalkyl;
R.sub.1 is hydrogen, halogen, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, COR.sub.6, NR.sub.7 R.sub.8, CONR.sub.9 R.sub.10 or SO.sub.2 NR.sub.11 R.sub.12 ;
R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl or C.sub.1 -C.sub.4 alkylsulfonyl; and
R.sub.3 and R.sub.4, independently of one another, are each hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.1 -C.sub.4 alkoxy or NR.sub.12 R.sub.13.
South African patent application No. 84/2722 (Swiss priority 4/13/83) discloses herbicidal benzenesulfonamides of formula ##STR10## wherein
A is a radical of the formula CR.sub.6 R.sub.7 XR.sub.8, CR.sub.9 R.sub.10 R.sub.11 or CHR.sub.7 SCQR.sub.21 ;
R.sub.1 is hydrogen, halogen, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, YR.sub.14, CONR.sub.12 R.sub.13, NR.sub.12 R.sub.13, SONR.sub.15 R.sub.16, OSO.sub.2 R.sub.17 or COR.sub.18 ;
R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl or C.sub.1 -C.sub.4 alkylsulfonyl;
R.sub.3 and R.sub.4, independently of one another, are each hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.2 -C.sub.5 alkoxyalkyl or NR.sub.19 R.sub.20 ;
R.sub.9 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl or C.sub.1 -C.sub.4 alkylsulfonyl;
R.sub.10 is hydrogen, halogen or methyl;
R.sub.11 is a radical COR.sub.24 or a C.sub.1 -C.sub.4 alkyl group that is mono- or polysubstituted by substituents selected from the group: cyano, nitro, hydroxyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, etc.
R.sub.18 is H, C.sub.1 -C.sub.4 alkoxy and various other organic radicals.
There is a continuing need for new herbicidal compounds which have safety to selective crops and which control both grassy and broadleaf weeds.
SUMMARY OF THE INVENTION
This invention relates to certain compounds of the structural formula: ##STR11## wherein
R is H or CH.sub.3 ;
R.sub.1 is C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.4 alkoxyalkyl, C.sub.2 -C.sub.4 haloalkyl, C.sub.3 -C.sub.4 alkenyl or C.sub.3 -C.sub.4 alkynyl;
R.sub.2 is C.sub.2 -C.sub.6 alkoxy, C.sub.3 -C.sub.6 cycloalkoxy, C.sub.4 -C.sub.6 cycloalkylalkoxy, C.sub.1 -C.sub.6 haloalkoxy, C.sub.2 -C.sub.6 alkenyloxy, C.sub.2 -C.sub.6 haloalkenyloxy, C.sub.3 -C.sub.6 alkynyloxy, C.sub.3 -C.sub.6 haloalkynyloxy, C.sub.2 -C.sub.4 alkoxyalkoxy, C.sub.2 -C.sub.4 haloalkoxyalkoxy, C.sub.2 -C.sub.4 alkylthioalkoxy, C.sub.2 -C.sub.4 halaolkylthioalkoxy, C.sub.2 -C.sub.4 alkylsulfinylalkoxy, C.sub.2 -C.sub.4 haloalkylsulfinylalkoxy, C.sub.2 -C.sub.4 alkylsulfonylalkoxy, C.sub.2 -C.sub.4 halaolkylsulfonylalkoxy, C.sub.2 -C.sub.4 cyanoalkoxy, OCH.sub.2 C(O)CH.sub.3, OCH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkoxy, C.sub.1 -C.sub.8 alkylthio, C.sub.3 -C.sub.6 cycloalkylthio, C.sub.4 -C.sub.6 cycloalkylalkylthio, C.sub.1 -C.sub.8 haloalkylthio, C.sub.2 -C.sub.6 alkenylthio, C.sub.2 -C.sub.6 haloalkenylthio, C.sub.3 -C.sub.6 alkynylthio, C.sub.3 -C.sub.6 haloalknynlthio, C.sub. 2 -C.sub.4 alkoxyalkylthio, C.sub.2 -C.sub.4 haloalkoxyalkylthio, C.sub.2 -C.sub.4 alkylthioalkylthio, C.sub.2 -C.sub.4 haloalkylthioalkylthio, C.sub.2 -C.sub.4 cyanoalkylthio, SCH.sub.2 C(O)CH.sub.3, SCH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkylthio, SC.sub.6 H.sub.5, SCH.sub.2 C.sub.6 H.sub.5, C.sub.1 -C.sub.8 alkylsulfinyl, C.sub.3 -C.sub.6 cycloalkylsulfinyl, C.sub.4 -C.sub.6 cycloalkylalkylsulfinyl, C.sub.1 -C.sub.8 haloalkylsulfinyl, C.sub.2 -C.sub.6 alkenylsulfinyl, C.sub.2 -C.sub.6 haloalkenylsulfinyl, C.sub.3 -C.sub.6 alkynylsulfinyl, C.sub.3 -C.sub.6 haloalkynylsulfinyl, C.sub.2 -C.sub.4 alkoxyalkylsulfinyl, C.sub.2 -C.sub.4 haloalkoxyalkylsulfinyl, C.sub.2 -C.sub.4 cyanoalkylsulfinyl, S(O)CH.sub.2 C(O)CH.sub.3, S(O)CH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkylsulfinyl, C.sub.2 -C.sub.8 alkylsulfonyl, C.sub.3 -C.sub.6 cycloalkylsulfonyl, C.sub.4 -C.sub.6 cycloalkylalkylsulfonyl, C.sub.1 -C.sub.8 haloalkylsulfonyl, C.sub.2 -C.sub.6 alkenylsulfonyl, C.sub.2 -C.sub.6 haloalkenylsulfonyl, C.sub.3 -C.sub.6 alkynylsulfonyl, C.sub.3 -C.sub.6 haloalkynylsulfonyl, C.sub.2 -C.sub.4 alkoxyalkylsulfonyl, C.sub.2 -C.sub.4 haloalkoxyalkylsulfonyl, C.sub.2 -C.sub.4 cyanoalkylsulfonyl, SO.sub.2 CH.sub.2 C(O)CH.sub.3, SO.sub.2 CH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkylsulfonyl, CH.sub.2 F, CHF.sub.2, CH.sub.2 Cl, CHCl.sub.2, CH.sub.2 Br, CHBr.sub.2, C.sub.2 -C.sub.6 alkyl substituted with 1-3 atoms of F, Cl or Br, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 haloalkenyl, C.tbd.CH, C.sub.2 -C.sub. 6 haloalkynyl, OC(O)C.sub.1 -C.sub.4 alkyl, CH.sub.2 C(O)NR.sub.a R.sub.b, NHCH.sub.3, NR.sub.b R.sub.c or C.sub.1 -C.sub.4 alkyl substituted with C.sub.1 -C.sub.4 alkoxy, C.sub.3 -C.sub.4 cycloalkoxy, cyclopropylmethoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.2 -C.sub.4 alkenyloxy, C.sub.2 -C.sub.4 haloalkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, C.sub.3 -C.sub.4 haloalkynyloxy, C.sub.2 -C.sub.4 alkoxyalkoxy, C.sub.2 -C.sub.4 aminoalkoxy, C.sub.1 -C.sub.4 alkylcarbonyloxy, C.sub.1 -C.sub.4 haloalkylcarbonyloxy, C.sub.1 -C.sub.4 carbamoyloxy, C.sub.1 -C.sub.4 alkoxycarbonyloxy, OH, OP(O)(OC.sub.1 -C.sub.2 alkyl).sub.2, C.sub.1 -C.sub.4 alkylsulfonyloxy, C.sub.1 -C.sub.2 haloalkylsulfonyloxy, OSi(CH.sub.3).sub.3, OSi(CH.sub.3).sub.2 C(CH.sub.3).sub.3, C.sub.1 -C.sub.4 alkylthio, C.sub.3 -C.sub.4 cycloalkylthio, cyclopropylmethylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.2 -C.sub.4 alkenylthio, C.sub.2 -C.sub.4 haloalkenylthio, C.sub.3 -C.sub.4 alkynylthio, C.sub.3 -C.sub.4 haloalkynylthio, C.sub.2 -C.sub.4 alkoxyalkylthio, C.sub.2 -C.sub.4 aminoalkylthio, SH, SP(O)(OC.sub.1 -C.sub.2 alkyl).sub.2, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.3 -C.sub.4 cycloalkylsulfonyl, cyclopropylmethylsulfinyl, C.sub.1 -C.sub.4 haloalkylsulfinyl, C.sub.2 -C.sub.4 alkenylsulfinyl, C.sub.2 -C.sub.4 haloalkenylsulfinyl, C.sub.3 -C.sub.4 alkynylsulfinyl, C.sub.3 -C.sub.4 haloalkynylsulfinyl, C.sub.2 -C.sub.4 alkoxyalkylsulfinyl, C.sub.2 -C.sub.4 aminoalkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.3 -C.sub.4 cycloalkylsulfonyl, cyclopropylmethylsulfonyl, C.sub.1 -C.sub.4 haloalkylsulfonyl, C.sub.2 -C.sub.4 alkenylsulfonyl, C.sub.2 -C.sub.4 haloalkenylsulfonyl, C.sub.3 -C.sub.4 alkynylsulfonyl, C.sub.3 -C.sub.4 haloalkynylsulfonyl, C.sub.2 -C.sub.4 alkoxyalkylsulfonyl or C.sub.2 -C.sub.4 aminoalkylsulfonyl;
R.sub.a and R.sub.b are independently H or C.sub.1 -C.sub.3 alkyl;
R.sub.c is C.sub.2 -C.sub.4 alkyl, cyclopropylmethyl, C.sub.2 -C.sub.4 cyanoalkyl, CH.sub.2 C(O)CH.sub.3, CH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 haloalkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.4 haloalkynyl, C.sub.1 -C.sub.4 alkyl substituted with C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, OH, NH.sub.2, NHCH.sub.3 or N(CH.sub.3).sub.2 ;
X is CH.sub.3, OCH.sub.3, OC.sub.2 H.sub.5, Cl or Br;
Y is C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, OCH.sub.2 CH.sub.2 F, OCH.sub.2 CHF.sub.2, OCH.sub.2 CF.sub.3, NHCH.sub.3 or N(CH.sub.3).sub.2 ; and
Z is CH or N; and their agriculturally suitable salts; provided that
(1) when X is Cl or Br, then Z is CH and Y is C.sub.1 -C.sub.2 alkoxy, NHCH.sub.3 or N(VCH.sub.3).sub.2 ; and
(2) when R.sub.2 is SCH.sub.3, then R is H, R.sub.1 is CH.sub.3, X is OCH.sub.3, Y is OCH.sub.3 and Z is CH.
In the above definitions, theterm "alkyl", used either alone or in compound words such as "alkylthio" or haloalkyl", denotes straight chain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or the different butyl, pentyl, hexyl, heptyl and octyl isomers.
Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the different butoxy, pentoxy or hexoxy isomers.
Alkenyl denotes straight chain or branched alkenes, e.g., vinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl, pentenyl and hexenyl isomers.
Alkynyl denotes straight chain or branched alkynes, e.g., ethynyl, 1-propynyl, 2-propynyl and the different butynyl, pentynyl and hexynyl isomers.
Cycloalkyl denotes cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
C.sub.4 -C.sub.6 cycloalkylalkyl means cyclopropylmethyl through cyclopropylpropyl or cyclopentylmethyl.
The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl" said alkyl may be partially or fully substituted with halogen atoms, which may be the same or different. Examples of haloalkyl include CH.sub.2 CH.sub.2 F, CF.sub.2 CF.sub.3 and CH.sub.2 CHFCl.
The total number of carbon atoms in a substituent group is indicated by the C.sub.i -C.sub.j prefix where i and j are numbers from 1 to 8. For example, C.sub.1 -C.sub.3 alkylsulfonyl would designate methylsulfonyl through propylsulfonyl, C.sub.2 alkoxyalkoxy would designate OCH.sub.2 OCH.sub.3 ; C.sub.4 alkoxyalkoxy would designate the various isomers of an alkoxy group substituted with a second alkoxy group containing a total of 4 carbon atoms, examples including OCH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 and OCH.sub.2 CH.sub.2 OCH.sub.2 CH; C.sub.2 cyanoalkyl would designate CH.sub.2 CN and C.sub.3 cyanoalkyl would designate CH.sub.2 CH.sub.2 CN and CH(CN)CH.sub.3 ; C.sub.4 aminoalkoxy would designate the various isomers of an alkoxy group substituted by an amino, alkylamino or dialkylamino group containing a total of 4 carbon atoms, examples including OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2 and OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 ; as further example, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.1 - C.sub.2 alkyl would designate the various isomers of a methyl group substituted by a C.sub.1 -C.sub.2 alkoxy group and optionally substituted by a C.sub.1 -C.sub.3 alkyl group, examples including CH.sub.2 OCH.sub.3 and CH(CH.sub.2 CH.sub.2 CH.sub.3)OCH.sub.2 CH.sub.3.
Compounds of the invention which are preferred for their higher herbicidal activity, greater plant growth regulant activity and/or more favorable ease of synthesis are:
(1) Compounds of Formula I wherein
R.sub.2 is a C.sub.2 -C.sub.6 alkoxy, C.sub.1 -C.sub.8 alkylthio, C.sub.1 -C.sub.8 alkylsulfinyl, C.sub.2 -C.sub.8 alkylsulfonyl, C.sub.3 -C.sub.6 alkenyloxy, C.sub.3 -C.sub.6 alkynyloxy, C.sub.3 -C.sub.6 alkenylthio, C.sub.3 -C.sub.6 alkenylsulfinyl, C.sub.3 -C.sub.6 alkenylsulfonyl, C.sub.3 -C.sub.6 alkynylthio, C.sub.3 -C.sub.6 alkynylsulfinyl, C.sub.3 -C.sub.6 alkynylsulfonyl, OCH.sub.2 CH.sub.2 OCH.sub.3, OCH.sub.2 CH.sub.2 SCH.sub.3, OCH.sub.2 CH.sub.2 S(O)CH.sub.3, OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3, C.sub.2 -C.sub.6 alkyl substituted with 1-3 atoms of F, Cl or Br, CH.sub.2 F, CHF.sub.2, C.sub.1 -C.sub.4 alkyl substituted with C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 alkylthio, C.sub.1 -C.sub.2 alkylsulfinyl or C.sub.1 -C.sub.2 alkylsulfonyl, OCF.sub.2 H, OCH.sub.2 CH.sub.2 F, OCH.sub.2 CHF.sub.2, OCH.sub.2 CF.sub. 3, OCH.sub.2 CH.sub.2 Cl, S-cyclohexyl, SC.sub.6 H.sub.5 or SCH.sub.2 C.sub.6 H.sub.5 ;
(2) Compounds of Preferred (1) where
R.sub.2 is CH.sub.3 S, C.sub.3 -C.sub.6 alkenyloxy, C.sub.3 -C.sub.6 alkynyloxy, C.sub.3 -C.sub.6 alkenylthio, C.sub.3 -C.sub.6 alkenylsulfinyl, C.sub.3 ;14 C.sub.6 alkenylsulfonyl, C.sub.3 -C.sub.6 alkynylthio, C.sub.3 -C.sub.6 alkynylsulfinyl, C.sub.3 -C.sub.6 alkynylsulfonyl, C.sub.2 -C.sub.6 alkyl substituted with 1-3 atoms of F, Cl or Br, CH.sub.2 F, CHF.sub.2, C.sub.1 -C.sub.4 alkyl substituted in a nonbenzylic position with C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 alkylthio, C.sub.1 -C.sub.2 alkylsulfinyl or C.sub.1 -C.sub.2 alkylsulfonyl, OCH.sub.2 CH.sub.2 OCH.sub.3, OCH.sub.2 CH.sub.2 SCH.sub.3, OCH.sub.2 CH.sub.2 S(O)CH.sub.3, OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3, OCF.sub.2 H, OCH.sub.2 CH.sub.2 F, OCH.sub.2 CHF.sub.2, OCH.sub.2 CF.sub.3, OCH.sub.2 CH.sub.2 Cl, S-cyclohexyl, SC.sub.6 H.sub.5 or SCH.sub.2 C.sub.6 H.sub.5.
(3) Compounds of Preferred (2) wherein R is H;
(4) Compounds of Preferred (3) wherein R.sub.2 is CH.sub.3 S, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkenylthio, C.sub.3 -C.sub.4 alkenylsulfinyl, C.sub.3 -C.sub.4 alkenylsulfonyl, C.sub.2 -C.sub.3 alkyl substituted with 1-3 atoms of F or Cl, CH.sub.2 F, CHF.sub.2, OCHF.sub.2, OCH.sub.2 CH.sub.2 F, OCH.sub.2 CF.sub.3 or OCH.sub.2 CH.sub.2 Cl.
(5) Compounds of Preferred (4) wherein
R.sub.1 is CH.sub.3 or CH.sub.2 CH.sub.3 ;
X is CH.sub.3, OCH.sub.3 or Cl; and
Y is CH.sub.3, OCH.sub.3, C.sub.2 H.sub.5 or OC.sub.2 H.sub.5.
(6) Compounds of Preferred (5) wherein
R.sub.2 is allyloxy, allythio, propargyloxy, propargylthio, CH.sub.2 F, OCHF.sub.2, OCH.sub.2 CH.sub.2 F or CH.sub.3 S.
(7) Compounds of Preferred (1) wherein
R.sub.2 is C.sub.2 -C.sub.6 alkoxy, C.sub.2 -C.sub.8 alkylthio, C.sub.2 -C.sub.8 alkylsulfonyl, C.sub.1 -C.sub.8 alkylsulfinyl, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.1 -C.sub.2 alkyl, CH(H, C.sub.1 -C.sub.3 alkyl)SC.sub.1 -C.sub.2 alkyl, CH(H, C.sub.1 -C.sub.3 alkyl)S(O)C.sub.1 -C.sub.2 alkyl or CH(H, C.sub.1 -C.sub.3 alkyl)SO.sub.2 C.sub.1 -C.sub.2 alkyl.
(8) Compounds of Preferred (7) wherein R is H.
(9) Compounds of Preferred (8) wherein
R.sub.2 is C.sub.2 -C.sub.4 alkxoy, C.sub.2 -C.sub.4 alkylthio, C.sub.2 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkylsulfinyl, CH.sub.2 OC.sub.1 -C.sub.2 alkyl, CH.sub.2 SC.sub.1 -C.sub.2 alkyl, CH.sub.2 S(O)C.sub.1 -C.sub.2 alkyl or CH.sub.2 SO.sub.2 C.sub.1 -C.sub.2 alkyl.
(10) Compounds of Preferred (9) wherein
R.sub.1 is CH.sub.3 or C.sub.2 H.sub.5
X is CH.sub.3, OCH.sub.3 or Cl; and
Y is CH.sub.3, OCH.sub.3, C.sub.2 H.sub.5 or OC.sub.2 H.sub.5.
(11) Compounds of Preferred (10) wherein
R.sub.2 is C.sub.2 -C.sub.3 alkoxy, C.sub.2 -C.sub.3 alkylthio, C.sub.1 -C.sub.3 alkylsulfinyl, CH.sub.2 OCH.sub.3, CH.sub.2 SCH.sub.3, CH.sub.2 S(O)CH.sub.3 or CH.sub.2 SO.sub.2 CH.sub.3.
(12) Compounds of Formula I wherein
R.sub.2 is C.sub.3 -C.sub.6 cycloalkoxy, C.sub.4 -C.sub.6 cycloalkylalkoxy, OCF.sub.2 Cl, OCF.sub.2 Br, OCF.sub.3, OCF.sub.2 CF.sub.2 H, OCF.sub.2 CHFCl, OCF.sub.2 CHFBr, OCF.sub.2 CF.sub.3, OCH.sub.2 CH.sub.2 Br, OCH.sub.2 CCl.sub.3, C.sub.3 -C.sub.6 haloalkoxy, vinyloxy, C.sub.2 -C.sub.6 haloalkenyloxy, C.sub.3 -C.sub.6 haloalkynyloxy, OCH.sub.2 OCH.sub.3, OCH.sub.2 OCH.sub.2 CH.sub.3, OCH(CH.sub.3)OCH.sub.3, C.sub.4 alkoxyalkoxy, C.sub.2 -C.sub.4 haloalkoxyalkoxy, OCH.sub.2 SCH.sub.3, OCH.sub.2 SCH.sub.2 CH.sub.3, OCH(CH.sub.3)SCH.sub.3, C.sub.4 alkylthioalkoxy, C.sub.2 -C.sub.4 haloalkylthioalkoxy, OCH.sub.2 S(O)CH.sub.3, OCH.sub.2 S(O)CH.sub.2 CH.sub.3, OCH(CH.sub.3)S(O)CH.sub.3, C.sub.4 alkylsulfinylalkoxy, C.sub.2 -C.sub.4 haloalkylsulfinylalkoxy, OCH.sub.2 SO.sub.2 CH, OCH.sub.2 SO.sub.2 CH.sub.2 CH.sub.3, OCH(CH.sub.3)SO.sub.2 CH.sub.3, C.sub.4 alkylsulfonylalkoxy, C.sub.2 -C.sub.4 haloalkylsulfonylalkoxy, C.sub.2 -C.sub.4 cyanoalkoxy, OCH.sub.2 C(O)CH.sub.3, OCH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkoxy, C.sub.2 -C.sub.5 cycloalkylthio, C.sub.4 -C.sub.6 cycloalkylalkylthio, SCF.sub.2 H, SCF.sub.2 Cl, SCF.sub.2 Br, SCF.sub.3, C.sub.2 -C.sub.8 haloalkylthio, vinylthio, C.sub.2 -C.sub.6 haloalkenylthio, C.sub.3 -C.sub.6 haloalkynylthio, C.sub. 2 -C.sub.4 alkoxyalkylthio, C.sub.2 -C.sub.4 haloalkoxyalkylthio, C.sub.2 -C.sub.4 alkylthioalkythio, C.sub.2 -C.sub.4 haloalkylthioalkylthio, C.sub.2 -C.sub.4 cyanoalkylthio, SCH.sub.2 C(O)CH.sub.3, SCH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalklthio, C.sub.3 -C.sub.6 cycloalkylsulfinyl, C.sub.4 -C.sub.6 cycloalkylalkylsulfinyl, C.sub.1 -C.sub.8 haloalkylsulfinyl, vinylsulfinyl, C.sub.2 -C.sub.6 haloalkenylsulfinyl, C.sub.3 -C.sub.6 haloalkynylsulfinyl, C.sub.2 -C.sub.4 alkoxyalkylsulfinyl, C.sub.2 -C.sub.4 haloalkoxyalkylsulfinyl, C.sub.2 -C.sub.4 cyanoalkylsulfinyl, S(O)CH.sub.2 C(O)CH.sub.3, S(O)CH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkylsulfinyl, C.sub.3 -C.sub.6 cycloalkylsulfonyl, C.sub.4 -C.sub.6 cycloalkylalkylsulfonyl, C.sub.1 -C.sub.8 haloalkylsulfonyl, vinylsulfonyl, C.sub.2 -C.sub.6 haloalkenylsulfonyl, C.sub.3 -C.sub.6 haloalkynylsulfonyl, C.sub.2 -C.sub.4 alkoxyalkylsulfonyl, C.sub.2 -C.sub.4 haloalkoxysulfonyl, C.sub.2 -C.sub.4 cyanoalkylsulfonyl, SO.sub.2 CH.sub.2 C(O)CH.sub.3, SO.sub.2 CH.sub.2 CH.sub.2 C(O)CH.sub. 3, C.sub.2 -C.sub.4 aminoalkylsulfonyl, CH.sub.2 Cl, CHCl.sub.2, CH.sub.2 Br, CHBr.sub.2, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 haloalkenyl, C.tbd.CH, C.sub.2 -C.sub.6 haloalkynyl, OC(O)C.sub.1 -C.sub.4 alkyl, CH.sub.2 C(O)NR.sub.a R.sub.b, NHCH.sub.3, NR.sub.b R.sub.c or C.sub.1 -C.sub.4 alkyl substituted with C.sub.3 -C.sub.4 alkoxy, C.sub.3 -C.sub.4 cycloalkoxy, cyclopropylmethoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.2 -C.sub.4 alkenyloxy, C.sub.2 -C.sub.4 haloalkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, C.sub.3 -C.sub.4 haloalkynyloxy, C.sub.2 -C.sub.4 alkoxyalkoxy, C.sub.2 -C.sub.4 aminoalkoxy, C.sub.1 -C.sub.4 alkylcarbonyloxy, C.sub.1 -C.sub.4 haloalkylcarbonyloxy, C.sub.1 -C.sub.4 carbamoyloxy, C.sub.1 -C.sub.4 alkoxycarbonyloxy, OH, OP(O)(OC.sub.1 -C.sub.2 alkyl).sub.2, C.sub.1 -C.sub.4 alkylsulfonyloxy, C.sub.1 -C.sub.2 haloalkylsulfonyloxy, OSi(CH.sub.3).sub.3, OSi(CH.sub.3).sub.2 C(CH.sub.3).sub.3, C.sub.3 -C.sub.4 alkylthio, C.sub.3 -C.sub.4 cycloalkylthio, cyclopropylmethylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.2 -C.sub.4 alkenylthio, C.sub.2 -C.sub.4 haloalkenylthio, C.sub.3 -C.sub.4 alkynylthio, C.sub.3 -C.sub.4 haloalkynylthio, C.sub.2 -C.sub.4 alkoxyalkylthio, C.sub.2 -C.sub.4 aminoalkylthio, SH, SP(O)(OC.sub.1 -C.sub.2 alkyl).sub.2, C.sub.3 -C.sub.4 alkylsulfinyl, C.sub.3 - C.sub.4 cycloalkylsulfinyl, cyclopropylmethylsulfinyl, C.sub.1 -C.sub.4 haloalkylsulfinyl, C.sub.2 -C.sub.4 alkenylsulfinyl, C.sub.2 -C.sub.4 haloalkenylsulfinyl, C.sub.3 -C.sub.4 alkynylsulfinyl, C.sub.3 -C.sub.4 haloalkynylsulfinyl, C.sub.2 -C.sub.4 alkoxyalkylsulfinyl, C.sub.2 -C.sub.4 aminoalkylsulfinyl, C.sub.3 -C.sub.4 alkylsulfonyl, C.sub.3 -C.sub.4 cycloalkylsulfonyl, cyclopropylmethylsulfonyl, C.sub.1 -C.sub.4 haloalkylsulfonyl, C.sub.2 -C.sub.4 alkenylsulfonyl, C.sub.2 -C.sub.4 haloalkenylsulfonyl, C.sub.3 -C.sub.4 alkynylsulfonyl, C.sub.3 -C.sub.4 haloalkynylsulfonyl, C.sub.2 -C.sub.4 alkoxyalkylsulfonyl or C.sub.2 -C.sub.4 aminoalkylsulfonyl.
(13) Compounds of Preferred (12) wherein
R.sub.2 is C.sub.3 -C.sub.6 cycloalkoxy, C.sub.4 -C.sub.6 cycloalkylalkoxy, OCF.sub.2 Cl, OCF.sub.2 Br, OCF.sub.3, OCF.sub.2 CF.sub.2 H, OCF.sub.2 CHFCl, OCF.sub.2 CHFBr, OCF.sub.2 CF.sub.3, OCH.sub.2 CH.sub.2 Br, OCH.sub.2 CCl.sub.3, C.sub.3 -C.sub.6 haloalkoxy, vinyloxy, C.sub.2 -C.sub.6 haloalkenyloxy, OCH.sub.2 OCH.sub.3, OCH.sub.2 OCH.sub.2 CH.sub.3, OCH(CH.sub.3)OCH.sub.3, C.sub.4 alkoxyalkoxy, C.sub.2 -C.sub.4 haloalkoxyalkoxy, OCH.sub.2 SCH.sub.3, OCH.sub.2 SCH.sub.2 CH.sub.3, OCH(CH.sub.2)SCH.sub.3, C.sub.4 alkylthioalkoxy, C.sub.2 -C.sub.4 haloalkylthioalkoxy, OCH.sub.2 S(O)CH.sub.3, OCH.sub.2 S(O)CH.sub.2 CH.sub.3, OCH(CH.sub.3)S(O)CH.sub.3, C.sub.4 alkylsulfinylalkoxy, C.sub.2 -C.sub.4 haloalkylsulfinylalkoxy, OCH.sub.2 SO.sub.2 CH.sub.3, OCH.sub.2 SO.sub.2 CH.sub.2 CH.sub.3, OCH(CH.sub.3)SO.sub.2 CH.sub.3, C.sub.4 alkylsulfonylalkoxy, C.sub.2 -C.sub.4 haloalkylsulfonylalkoxy, C.sub.2 -C.sub.4 cyanoalkoxy, OCH.sub.2 C(O)CH.sub.3, OCH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkoxy, C.sub.3 -C.sub.5 cycloalkylthio, SCF.sub.3, SCF.sub.2 Cl, SCF.sub.2 Br, C.sub.4 -C.sub.6 cycloalkylalkylthio, SCF.sub.2 H, C.sub.2 -C.sub.6 haloalkylthio, vinylthio, C.sub.2 -C.sub.6 haloalkenylthio, C.sub.2 -C.sub.4 alkoxyalkylthio, C.sub.2 -C.sub.4 haloalkoxyalkylthio, C.sub.2 -C.sub.4 alkylthioalkylthio, C.sub.2 -C.sub.4 haloalkylthioalkylthio, C.sub.2 -C.sub.4 cyanoalkylthio, SCH.sub.2 C(O)CH.sub.3, SCH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkylthio, C.sub.3 -C.sub.6 cycloalkylsulfinyl, C.sub.4 -C.sub.6 cycloalkylalkylsulfinyl, C.sub.1 -C.sub.6 haloalkylsulfinyl, vinylsulfinyl, C.sub.2 -C.sub.6 haloalkenylsulfinyl, C.sub.2 -C.sub.4 alkoxyalkylsulfinyl, C.sub.2 -C.sub.4 halolkoxyalkylsulfinyl, C.sub.2 -C.sub.4 cyanoalkylsulfinyl, S(O)CH.sub.2 C(O)CH.sub.3, S(O)CH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkylsulfinyl, C.sub.3 -C.sub.6 cycloalkylsulfonyl, C.sub.4 -C.sub.6 cycloalkylalkylsulfonyl, C.sub.1 -C.sub.6 haloalkylsulfonyl, vinylsulfonyl, C.sub.2 -C.sub.6 haloalkenylsulfonyl, C.sub.2 -C.sub.4 alkoxyalkylsulfonyl, C.sub.2 -C.sub.4 haloalkoxysulfonyl, C.sub.2 -C.sub.4 cyanoalkylsulfonyl, SO.sub.2 CH.sub.2 C(O)CH.sub.3, SO.sub.2 CH.sub.2 CH.sub.2 (O)CH.sub.3, C.sub.2 -C.sub.4 aminoalkylsulfonyl, CHBr.sub.2, C.sub.2 -C.sub.6 alkenyl substituted by one or more fluorine or bromine atoms, C.tbd.CH, C.sub.3 -C.sub.6 haloalkynyl, NR.sub.b R.sub.c, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.1 -C.sub.4 haloalkyl having 1 or 2 halogen atoms, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.2 -C.sub.4 haloalkenyl, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.3 -C.sub.5 alkynyl, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.2 -C.sub.4 alkoxyalkyl, CH(H, C.sub.1 -C.sub.3 alkyl)SC.sub.1 -C.sub.4 haloalkyl having 1 or 2 halogen atoms, CH(H, C.sub.1 -C.sub.3 alkyl)SC.sub.2 -C.sub.4 haloalkenyl, CH(H, C.sub.1 -C.sub.3 alkyl)SC.sub.3 -C.sub.4 alkynyl, CH(H, C.sub.1 -C.sub.3 alkyl)SC.sub.2 -C.sub.4 alkoxyalkyl, CH(H, C.sub.1 -C.sub.3 alkyl)S(O)C.sub.1 -C.sub.4 haloalkyl having 1 or 2 halogen atoms, CH(H, C.sub.1 -C.sub.3 alkyl)S(O)C.sub.2 -C.sub.4 haloalkenyl, CH(H, C.sub.1 -C.sub.3 alkyl)S(O)C.sub.3 -C.sub.4 alkynyl, CH(H, C.sub.1 -C.sub.3 alkyl)S(O)C.sub.2 -C.sub.4 alkoxyalkyl, CH(H, C.sub.1 -C.sub.3 alkyl)SO.sub.2 C.sub.1 -C.sub.4 haloalkyl having 1 or 2 halogen atoms. CH(H, C.sub.1 -C.sub.3 alkyl)SO.sub.2 C.sub.2 -C.sub.4 haloalkenyl, CH(H, C.sub.1 -C.sub.3 alkyl)SO.sub.2 C.sub.3 -C.sub.4 alkynyl, CH(H, C.sub.1 -C.sub.3 alkyl)SO.sub.2 C.sub.2 -C.sub.4 alkoxyalkyl, or C.sub.1 -C.sub.4 alkyl substituted in a nonbenzylic position with C.sub.3 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylcarbonyloxy, C.sub.1 -C.sub.4 haloalkylcarbonyloxy, C.sub.1 -C.sub.4 carbamoyloxy, alkoxycarbonyloxy, C.sub.1 -C.sub.4 alkylsulfonyloxy, C.sub.1 -C.sub.2 haloalkylsulfonyloxy, C.sub.3 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.3 -C.sub.4 alkylsulfinyl or C.sub.3 -C.sub.4 alkylsulfonyl; and
R.sub.c is C.sub.2 -C.sub.4 cyanoalkyl, CH.sub.2 C(O)CH.sub.3, CH.sub.2 CH.sub.2 C(O)CH.sub.3, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 haloalkenyl, C.sub.3 -C.sub.4 alkynyl or C.sub.3 -C.sub.4 haloalkynyl; (14) Compounds of Preferred (13) wherein R is H. (15) Compounds of Preferred (14) wheren
R.sub.2 is OCF.sub.3, OCF.sub.2 CF.sub.3, OCH.sub.2 CH.sub.2 Br, C.sub.3 haloalkoxy, OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3, SCF.sub.2 H, SCF.sub.3, C.sub.2 haloalkylthio, C.sub.2 -C.sub.3 alkoxyalkylthio, C.sub.1 -C.sub.2 haloalkylsulfinyl, C.sub.1 -C.sub.2 haloalkylsulfonyl, C.tbd.CH, CH.sub.2 OC.sub.1 -C.sub.2 haloalkyl having 1 or 2 halogen atoms, CH.sub.2 SC.sub.1 -C.sub.2 haloalkyl having 1 or 2 halogen atoms, CH.sub.2 S(O)C.sub.1 -C.sub.2 haloalkyl having 1 or 2 halogen atoms, or CH.sub.2 SO.sub.2 C.sub.1 -C.sub.2 haloalkyl having 1 or 2 halogen atoms. (16) Compounds of Preferred (15) wherein
R.sub.1 is CH.sub.3 or CH.sub.2 CH.sub.3 ;
X is CH.sub.3, OCH.sub.3 or Cl; and
Y is CH.sub.3, OCH.sub.3, C.sub.2 H.sub.5 or OC.sub.2 H.sub.5. (17) Compounds of Preferred (16) wherein
R.sub.2 is OCF.sub.2 CF.sub.3, SCF.sub.2 H, SCH.sub.2 CH.sub.2 OCH.sub.3, S(O)CF.sub.2 H, SO.sub.2 CF.sub.2 H, C.tbd.CH, CH.sub.2 OCH.sub.2 CH.sub.2 F or CH.sub.2 OCH.sub.2 CHF.sub.2 ; (18) Compounds of Preferred (12) wherein
R.sub.2 is C.sub.3 -C.sub.6 haloalkynyloxy, C.sub.7 -C.sub.8 haloalkylthio, C.sub.3 -C.sub.6 haloalkynylthio, C.sub.7 -C.sub.8 haloalkylsulfinyl, C.sub.3 -C.sub.6 haloalkynylsulfinyl, C.sub.7 -C.sub.8 haloalkylsulfonyl, C.sub.3 -C.sub.6 haloalkynylsulfonyl, CH.sub.2 Cl, CHCl.sub.2, CH.sub.2 Br, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkenyl substituted with one or more chlorine atoms, C.sub.2 haloalkynyl, OC(O)C.sub.1 -C.sub.4 alkyl, CH.sub.2 C(O)NR.sub.a R.sub.b, NHCH.sub.3, NR.sub.b R.sub.c, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.3 -C.sub.4 alkyl, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.1 -C.sub.4 haloalkyl having 3 or more halogen atoms, CH(H, C.sub.1 -C.sub.3 alkyl)OC(O)C.sub.1 -C.sub.3 alkyl, CH(H, C.sub.1 .varies.C.sub.3 alkyl)OC(O)C.sub.1 -C.sub.3 haloalkyl, CH(H, C.sub.1 -C.sub.3 alkyl)OC.sub.1 -C.sub.4 carbamoyl, CH(H, C.sub.1 -C.sub.3 alkyl)OC(O)OC.sub.1 -C.sub.3 alkyl, CH(H, C.sub.1 -C.sub.3 alkyl)OSO.sub.2 C.sub.1 -C.sub.4 alkyl, CH(H, C.sub.1 -C.sub.3 alkyl)OSO.sub.2 C.sub.1 -C.sub.2 haloalkyl, CH(H, C.sub.1 -C.sub.3 alkyl)SC.sub.3 -C.sub.4 alkyl, CH(H, C.sub.1 -C.sub.3 alkyl)SC.sub.1 -C.sub.4 haloalkyl having 3 or more halogen atoms, CH(H, C.sub.1 -C.sub.3 alkyl)S(O)C.sub.3 -C.sub.4 alkyl, CH(H, C.sub.1 -C.sub.3 alkyl)S(O)C.sub.1 -C.sub.4 haloalkyl having 3 or more halogen atoms, CH(H, C.sub.1 -C.sub.3 alkyl)SO.sub.2 C.sub.3 -C.sub.4 alkyl, CH(H, C.sub.1 -C.sub.3 alkyl)SO.sub.2 C.sub.1 -C.sub.4 haloalkyl having 3 or more halogen atoms, C.sub.1 -C.sub.4 alkyl substituted in a nonbenzylic position by C.sub.2 -C.sub.4 haloalkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, C.sub.2 -C.sub.4 alkoxyalkoxy, C.sub.2 -C.sub.4 haloalkenylthio, C.sub.3 -C.sub.4 alkynylthio, C.sub.2 -C.sub.4 alkoxyalkylthio, C.sub.1 -C.sub.4 haloalkylsulfinyl, C.sub.2 -C.sub.4 haloalkenylsulfinyl, C.sub.3 -C.sub.4 alkynylsulfinyl, C.sub.2 -C.sub.4 alkoxyalkylsulfinyl, C.sub.1 -C.sub.4 haloalkylsulfonyl, C.sub.2 -C.sub.4 haloalkenylsulfonyl, C.sub.3 -C.sub.4 alkynylsulfonyl, or C.sub.2 -C.sub.4 alkoxyalkylsulfonyl, or C.sub.1 -C.sub.4 alkyl substituted by C.sub.3 -C.sub.4 cycloalkoxy, cyclopropylmethoxy, C.sub.2 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 haloalkynyloxy, C.sub.2 -C.sub.4 aminoalkoxy, OH, OP(O)(OC.sub.1 -C.sub.2 alkyl).sub.2, OSi(CH.sub.3).sub.3, OSi(CH.sub.3).sub.2 C(CH.sub.3).sub.3, cycloalkylthio, cyclopropylmethylthio, C.sub.2 -C.sub.4 alkenylthio, C.sub.3 -C.sub.4 haloalkynylthio, C.sub.2 -C.sub.4 aminoalkylthio, SH, SP(O)(OC.sub.1 -C.sub.2 alkyl).sub.2, C.sub.3 -C.sub.4 cycloalkylsulfinyl, cyclopropylmethylsulfinyl, C.sub.2 -C.sub.4 alkenylsulfinyl, C.sub.3 -C.sub.4 haloalkynylsulfinyl, C.sub.2 -C.sub.4 aminoalkylsulfinyl, C.sub.3 -C.sub.4 cycloalkylsulfonyl, cyclopropylmethylsulfonyl, C.sub.2 -C.sub.4 alkenylsulfonyl, C.sub.3 -C.sub.4 haloalkynylsulfonyl, or C.sub.2 -C.sub.4 aminoalkylsulfonyl; and R.sub.c is C.sub.2 -C.sub.4 alkyl, cyclopropylmethyl, or C.sub.1 -C.sub.4 alkyl substituted with C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, OH, NH.sub.2, NHCH.sub.3 or N(CH.sub.3 ).sub.2. (19) Compounds of Preferred (18) wherein R is H. (20) Compounds of Preferred (19) wherein
R.sub.2 is OCF.sub.2 CF.sub.2 H, C.sub.2 -C.sub.3 cyanoalkoxy, C.sub.2 -C.sub.3 aminoalkoxy, C.sub.2 -C.sub.4 cyanoalkylthio, C.sub.2 -C.sub.3 alkenyl, CH.sub.2 C(O)NR.sub.a R.sub.b, NHCH.sub.3, NR.sub.b R.sub.c, CH.sub.2 OC.sub.1 -C.sub.2 haloalkyl having 3 or more halogen atoms, CH.sub.2 OC(O)C.sub.1 -C.sub.2 alkyl, CH.sub.2 OSO.sub.2 C.sub.1 -C.sub.2 alkyl, CH.sub.2 SC.sub.1 -C.sub.2 haloalkyl having 3 or more halogen atoms, CH.sub.2 S(O)C.sub.1 -C.sub.2 haloalkyl having 3 or more halogen atoms or CH.sub.2 SO.sub.2 C.sub.1 -C.sub.2 haloalkyl having 3 or more halogen atoms. (21) Compounds of Preferred (20) wherein
R.sub.1 is CH.sub.3 or C.sub.2 H.sub.5 ;
X is CH.sub.3, OCH.sub.3 or Cl; and
Y is CH.sub.3, OCH.sub.3, C.sub.2 H.sub.5 or OC.sub.2 H.sub.5. (22) Compounds of Preferred (21) wherein
R.sub.2 is OCF.sub.2 CF.sub.2 H, OCH.sub.2 CH.sub.2 CN, SCH.sub.2 CH.sub.2 CN, CH.dbd.CH.sub.2, CH.sub.2 C(O)NH.sub.2, NHCH.sub.3, CH.sub.2 OCH.sub.2 CF.sub.3, CH.sub.2 OC(O)CH.sub.3 or CH.sub.2 OSO.sub.2 CH.sub.3.
A compound of the invention which is specifically preferred for its highest herbicidal activity, greatest plant growth regulant activity and/or most favorable ease of synthesis is:
2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminoaminosulfonyl]-4-(methylthio)benzoic acid, methyl ester, m.p. 201.degree.-202.degree. C.
DETAILED DESCRIPTION OF THE INVENTION
Synthesis
The compounds of Formula I can be prepared by one or more of the following methods described in Equations 1 to 3 and 14.
As shown in Equation 1, compounds of Formula I can be prepared by reacting an appropriately substituted sulfonyl isocyanate of Formula (1) with an appropriate amino or methylamino heterocycle of Formula (2).
A is ##STR12## and R, R.sub.1, R.sub.2, X, Y and Z are as previously defined. ##STR13##
The reaction is best carried out in inert aprotic organic solvents such as dichloromethane, 1,2-dichloroethane, tetrahydrofuran, or acetonitrile, at a temperature between 20.degree. and 85.degree. C. The order of addition is not critical; however, it is often convenient to add the sulfonyl isocyanate or a solution of it in the reaction solvent to a stirred suspension of the amine.
In some cases, the desired product is insoluble in the reaction solvent at ambient temperature and crystallizes from it in pure form. Products soluble in the reaction solvent are isolated by evaporation of the solvent. Compounds of Formula I then may be purified by trituration of the evaporation residue with solvents such as 1-chlorobutane or ethyl ether and filtration, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane, and heptane, or by chromatography on silica gel.
Many of the compounds of Formula I can be prepared by the procedure shown in Equation 2, where A, R, R.sub.1, and R.sub.2 are as previously defined. ##STR14##
The reaction shown in Equation 2 is carried out by contacting phenyl carbamates of Formula (3) with aminoheterocycles of Formula (2) in an inert organic solvent such as dioxane or tetrahydrofuran at temperatures of about 20.degree.-100.degree. C. for a period of about one-half to twenty-four hours. The product can be isolated by evaporation of the reaction solvent and purified by methods previously described.
Phenyl carbamates of Formula (3) can be prepared by the methods described, or modifications thereof known to those skilled in the art, in European Patent Application 81810282.4 (Publication No. 44,808), published Jan. 27, 1982; or South African Patent Application 825042.
Alternatively, many of the compounds of Formula I can be prepared by the method described in Equation 3, wherein A, R.sub.1, and R.sub.2 are as previously defined and R is H. ##STR15##
The reaction of Equation 3 can be carried out by contacting equimolar amounts of a sulfonamide of Formula (4) with a heterocyclic phenyl carbamate of Formula (5) in the presence of an equimolar amount of 1,8-diazabicyclo-[5.4.0]undec-7-ene (DBU), by methods analogous to those described in South African Patent Application 830441. The phenyl carbamate of Formula (5) can be prepared by methods, or modifications thereof known to those skilled in the art, described in South African Patent Application 825671 and South African Patent Application 825045.
Some of the compounds of Formula I may be prepared from compounds of Formula I where R.sub.2 is OH, NR.sub.b H or SH. See Equation 14 for a discussion of this method.
The unsubstituted and substituted alkoxy, alkenyloxy, and alkynyloxy benzenesulfonamide intermediates of Formula (4a) can be prepared by one or more of the following general methods.
As shown in Equation 4, one highly useful general route starts from the phenol (6). ##STR16## where R.sub.1 is as previously defined, and R.sub.3 is C.sub.2 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.4 -C.sub.6 cycloalkylalkyl, C.sub.1 -C.sub.6 haloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 haloalkenyl, C.sub.3 -C.sub.6 haloalkynyl, C.sub.3 -C.sub.6 alkynyl, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.2 -C.sub.4 haloalkoxyalkyl, C.sub.2 -C.sub.4 alkylthioalkyl, C.sub.2 -C.sub.4 haloalkylthioalkyl, CH.sub.2 C(O)CH.sub.3, CH.sub.2 CH.sub.2 C(O)CH.sub.3, or benzyl. M.sub.1 is Na or K. X.sub.1 is Cl, Br, I, ##STR17## or O.sup..sym. (R.sub.3).sub.2 BF.sub.4.sup..crclbar., or ##STR18##
A solution or suspension of 4-hydroxy-2-nitrobenzoic acid (6) in a suitable polar aprotic solvent, such as dichloromethane or N,N-dimethylformamide (DMF), is treated with at least two equivalents of R.sub.3 X.sub.1 (7) in the presence of at least two equivalents of a suitable base such as N,N-diisopropylethylamine or potassium carbonate and at a temperature between 20.degree. and 155.degree. C. for four to sixteen hours (Equation 4a). If the solvent is miscible with water, it is then evaporated, and the residue is taken up in dichloromethane. The product solution is washed with aqueous sodium or potassium carbonate solution and aqueous hydrochloric acid, and then is dried over a suitable desiccant such as magnesium sulfate. Filtration and evaporation of the solvent leaves (8) in semipurified form. It may be further purified through recrystallization or chromatography on a column of silica gel. The requisite alkylating, alkenylating, and alkynylating agents R.sub.3 X.sub.1 (7) are either known or may be made by a wide variety of methods known in the art.
In cases where R.sub.3 is not the same as R.sub.1, the ester (8) is treated with at least one equivalent of sodium or potassium hydroxide in a mixture of water and a suitable organic cosolvent such as ethanol or p-dioxane at a temperature between 20.degree. and 100.degree. C. for four to sixteen hours (Equation 4b). The reaction mixture is then acidified with concentrated hydrochloric acid. If the product separates out in crystalline form, it is collected. Otherwise the aqueous solution is extracted with ether. The ether solution is dried over sodium sulfate and filtered, and the solvent is evaporated to afford the carboxylic acid (10).
To convert carboxylic acid (10) to ester (12), a solution of it in pyridine is treated sequentially with p-toluenesulfonyl chloride and R.sub.1 OH (11) according to the general procedure of J. H. Brewster and C. J. Ciotti, Jr., J. Am. Chem. Soc. 1955, 77, 6214.
Alternatively, the carboxylic acid (10) may be converted to ester (12) through the use of excess R.sub.1 OH (11) and a strong acid catalyst such as hydrogen chloride as reviewed by C. A. Buehler and D. E. Pearson, Survey of Organic Syntheses, Wiley-Interscience, New York, 1970, pp 802-807 (Equation 4c).
The nitrobenzene (12) is reduced to the aniline (13) either by use of iron in acetic acid as reviewed by C. A. Buehler and D. E. Pearson (ibid, pp 413-414) or by hydrogenation using platinum sulfide as catalyst and the conditions of F. S. Dovel and H. Greenfield, J. Am. Chem. Soc., 87, 2767 (1965) (Equation 4d). When the other substituents present are not potentially susceptible to hydrogenation or hydrogenolysis, palladium may replace platinum sulfide as catalyst.
The aniline (13) is converted to the sulfonyl chloride (14) using the general procedures of H. Meerwein, G. Dittmar, R. Gollner, K. Hafner, F. Mensch, O. Steinfort, Chem. Ber., 90, 841 (1957) (Equation 4e). To limit the hydrolysis of the product during the coupling step, the use of dichloromethane as a cosolvent is advantageous.
Finally, the sulfonyl chloride (14) is aminated to give (4a) using two equivalents of ammonia in dichloromethane solution at a temperature between -30.degree. and -10.degree. C. (Equation 4f).
Alternatively, many of the sulfonamides of Formula (4a) or (4c') can be prepared via the route shown in Equation 5. ##STR19## where M.sub.1, R.sub.1, R.sub.a, R.sub.b, and X.sub.1 are as previously defined; R.sub.5 is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 haloalkyl or CH.sub.2 C(O)NR.sub.a R.sub.b ; and R.sub.3 is as previously defined or C.sub.2 -C.sub.4 aminoalkyl but not C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 haloalkenyl, C.sub.3 -C.sub.6 alkynyl or C.sub.3 -C.sub.6 haloalkynyl.
Phenol (15) is added to a solution of two equivalents of sodium in anhydrous methanol, ethanol, or amyl alcohol. A little more than one equivalent of R.sub.3 X.sub.1 (7) is added and the mixture is heated at reflux for 4 to 24 hours. The solvent is removed in vacuo and the residue is partitioned between 1N hydrochloric acid and ether. The ether phase is dried over sodium sulfate, and filtered. Evaporation of the ether leaves the phenol (16) (Equation 5a).
In Equations 5b, c, d, e and f compounds 17a, 18a, 19a, 21a and 14a have the same structure as 17, 18, 19, 21, and 14 respectively except that the OR.sub.3 substituent is replaced by R.sub.5.
The carboxylic acid (16/16a) is converted to ester (17/17a) through the use of excess R.sub.1 OH and a strong acid catalyst such as hydrogen chloride as reviewed by C. A. Buehler and D. E. Pearson (op.cit., pp 802-807) (Equation 5b).
The phenol (17/17a) is converted to the thiocarbamate (18/18a) through the use of dimethylthiocarbamoyl chloride and 1,4-diazabicyclo[2.2.2]octane (DABCO) in N,N-dimethylformamide according to the general procedure of M. S. Newman and H. A. Karnes, J. Org. Chem. 1966, 31, 3980 (Equation 5c). Alternatively a mixture of the phenol (17/17a), at least one equivalent of dimethylthiocarbamoyl chloride, at least one equivalent of triethylamine (Et.sub.3 N), and a catalytic amount of 4-dimethylaminopyridine (DMAP) in dichloromethane is heated at reflux for one to seven days. The reaction mixture is washed with 1N hydrochloric acid and 10% aqueous sodium hydroxide solution, then dried over magnesium sulfate and filtered. Evaporation of the solvent leaves crude (18/18a) which may be purified by chromatography on silica gel or by recrystallization if it is crystalline.
The thiocarbamate (18/18a) is converted to its isomer (19/19a) by heating according to the general procedure of M. S. Newman and H. A. Karnes (op.cit.) (Equation 5d).
To a solution of (19/19a) in anhydrous R.sub.1 OH (11) is added little more than one equivalent of NaOR.sub.1 (20). The mixture is heated at 60.degree.-70.degree. C. for 0.5-1 hour. The solvent is removed in vacuo, and the residue is partitioned between dichloromethane and water. The aqueous phase is washed with dichloromethane, acidified with 12N hydrochloric acid, and extracted with dichloromethane. The dichloromethane extracts are dried over sodium sulfate and filtered. Evaporation of the solvent leaves thiol (21/21a) (Equation 5e).
To a mixture of the thiol (21/21a) and at least one equivalent of sodium formate in formic acid is added at least three equivalents of hydrogen peroxide at such a rate as to keep the temperature between 40.degree. and 50.degree. C. The reaction mixture is then heated at 45.degree.-55.degree. C. for 1 to 5 hours. The excess peroxide is destroyed with sodium sulfite, and the solvent is evaporated. The residue is added to excess thionyl chloride, and a catalytic amount of N,N-dimethylformamide (DMF) is added. The mixture is heated at reflux for 8 to 24 hours, and then the solvent is evaporated. The residue is partitioned between water and ether. The ether solution is washed with aqueous sodium bicarbonate solution, dried over magnesium sulfate and filtered. Evaporation of the solvent leaves the sulfonyl chloride (14/14a) (Equation 5f).
Finally the sulfonyl chloride (14) is aminated giving the sulfonamide (4a) and likewise (14a) gives (4c') as already described for Equation 4f (Equation 5g).
Most of the sulfonamides (4a) can be prepared via the route shown in Equation 6 starting from 6-hydroxysaccharin (22). ##STR20## where R.sub.1 and X.sub.1 are as previously defined and R.sub.3 is as defined for Equation 4 or C.sub.2 -C.sub.4 cyanoalkyl.
6-Hydroxysaccharin (22) can be prepared as described by C. Finzi and M. Colonna, Atti. accad. Lincei, Classe, sci. fis., mat. mat., 1937, 26, 19 (Chem. Abst. 1938, 32, 3762). Alternatively, (4a), where R.sub.1 =CH.sub.3, R.sub.3 =C.sub.6 H.sub.5 CH.sub.2 may be prepared via the route described by Equation 5. A solution of this sulfonamide in dichloromethane is treated with one equivalent of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The solvent is evaporated, and the residue is dissolved in minimal water and acidified with concentrated hydrochloric acid to precipitate 6-benzyloxysaccharin. This is dissolved in ethanol containing palladium catalyst. The mixture is hydrogenated at 20.degree.-40.degree. C. and 1-10 psi until hydrogen uptake ceases. Filtration and evaporation of the solvent affords 6-hydroxysaccharin (22).
In the method described by Equation 6a, 6-hydroxysaccharin (22) is added to a solution of two equivalents sodium in anhydrous methanol, ethanol, or amyl alcohol. A little more than one equivalent of R.sub.3 X.sub.1 (7) is added and the mixture is heated at reflux for 4 to 24 hours. The solvent is removed in vacuo and the residue is dissolved in minimal water. It is acidified with concentrated hydrochloric acid. If the product crystallizes, it is collected, washed with dilute hydrochloric acid, and dried. If it does not crystallize, the aqueous mixture is extracted with dichloromethane. The dichloromethane phase is dried over sodium sulfate and filtered. Evaporation of the solvent leaves the saccharin (23) (Equation 6a).
A solution or suspension of the saccharin (23) in R.sub.1 OH (11) is saturated with hydrogen chloride. The mixture is heated at 65.degree.-80.degree. C. for 1-6 hours. The solvent and hydrogen chloride are evaporated. The residue is dissolved in dichloromethane, washed with aqueous sodium bicarbonate solution, dried over sodium sulfate, and filtered. Evaporation of the solvent affords the sulfonamide (4a) (Equation 6b).
Alternatively, saccharin (22) may be opened to the sulfonamide (24) using the conditions already described for the conversion of (23) to (4a) in Equation 6b (Equation 6c). To a solution of the sulfonamide (24) in anhydrous methanol, ethanol, amyl alcohol, or a suitable aprotic solvent such as N,N-dimethylformamide is added one equivalent of sodium or potassium methoxide, ethoxide, or tert-butoxide followed by the alkylating agent R.sub.3 X.sub.1 (7). The mixture is held at 20.degree.-80.degree. C. for 1-8 hours. The solvent is removed in vacuo, and the residue is dissolved in dichloromethane, washed with aqueous sodium bicarbonate solution, dried over Na.sub.2 SO.sub.4, and filtered. Evaporation of the solvent affords the sulfonamide (4a) (Equation 6d).
Many sulfonamides of Formulae (4a), (4b) and (4e) can be prepared by the methods shown in Equation 7. ##STR21## wherein M.sub.1, R.sub.1 and X.sub.1 are as previously defined, X.sub.2 is F, Cl, Br or I, W is O, S, or NR.sub.b ; R.sub.b is as previously defined; and R.sub.4 is R.sub.3 as defined for Equation 6 or H, CH.sub.3, cyclohexyl, or phenyl.
The hydroxysaccharin (22) is converted to the thiocarbamate (25) through the use of dimethylthiocarbamoyl chloride and 1,4-diazabicyclo[2.2.2]octane (DABCO) in N,N-dimethylformamide according to the general procedure, or modification thereof known to those skilled in the art, of M. S. Newman and H. A. Karnes (op.cit.) (Equation 7a).
The thiocarbamate (25) is converted to its isomer (26) by heating according to the general procedure, or modifications thereof known to those skilled in the art, of M. S. Newman and H. A. Karnes (ibid.) (Equation 7b).
To a solution of (26) in anhydrous methanol is added a little more than two equivalents of sodium methoxide. The mixture is heated at 60.degree.-70.degree. C. for 0.5-1 hour. The solvent is removed in vacuo, and the residue is partitioned between dichloromethane and water. The aqueous phase is washed with dichloromethane and acidified with concentrated hydrochloric acid. If the saccharin (27) crystallizes, it is collected, rinsed with dilute cold hydrochloric acid, and dried. If it does not crystallize, the aqueous phase is extracted with dichloromethane. The dichloromethane extracts are dried over sodium sulfate and filtered. Evaporation of the solvent leaves saccharin (27) (Equation 7c).
The mercaptan (27) is added to a solution of two equivalents sodium in anhydrous methanol, ethanol, or amyl alcohol. A little more than one equivalent of R.sub.4 X.sub.1 (28) is added, and the mixture is heated at reflux for 1 to 8 hours. The requisite alkylating, alkenylating, and alkynylating agents R.sub.4 X.sub.1 (28) are either known in the art or may be made by a wide variety of methods known in the art.
The solvent is removed in vacuo, and the residue is dissolved in minimal water. It is acidified with concentrated hydrochloric acid. If the saccharin (29) crystallizes, it is collected, washed with cold dilute hydrochloric acid, and dried. If it does not crystallize, the aqueous mixture is extracted with dichloromethane. The dichloromethane phase is dried over sodium sulfate and filtered. Evaporation of the solvent leaves the saccharin (29) (Equation 7d).
Alternatively, in many cases, the saccharins of Formula (29) or (29b) may be prepared by treating a halosaccharin (30) in a polar aprotic solvent such as N-N-dimethylformamide at 20.degree.-100.degree. C. with at least two equivalents of the corresponding thiolate or alkoxide of Formula (31) for 4-24 hours. The reaction is worked up by extraction of the solvent. The residue is dissolved in minimal water and acidified with concentrated hydrochloric acid. If the saccharin (29/29b) crystallizes, it is filtered. Otherwise the aqueous solution is extracted with dichloromethane, and evaporation of the solvent leaves the saccharin (29/29b) (Equation 7e).
Many 5-aminosaccharins (29a) can be prepared by heating the halosaccharin (30) in N,N-dimethylformamide under pressure at 125.degree.-190.degree. C. in the presence of amines for 8-16 hours. The reaction is worked up as described in the preceeding paragraph.
In addition, aminosaccharins (29a) wherein R.sub.4 is H can be alkylated in the same fashion as described previously for alkoxy and mercapto saccharins in Equations (6a) and (7d). The conversion of aminosaccharins (29a) into aminosulfonamides (4e) or (32a) can be effected using conditions described previously in Equations (6b and c) (Equation 7f).
The requisite precursor halosaccharins of Formula (30) may be prepared by conversion of the corresponding 4-halo-2-nitrobenzoic acids to esters of 2-(aminosulfonyl)-4-halobenzoic acids by use of methods analogous to those described in Equation 4. These esters are closed to the corresponding saccharins of Formula (30) by treatment with DBU according to the general method already described for the preparation of 6-benzyloxysaccharin.
Saccharins (29/29b) are similarly opened to the corresponding sulfonamides (4b/4a) using the conditions already described for the conversion of (23) to (4a) in Equation 6b (Equation 7f).
Alternatively, saccharin (27/29a) may be opened to the sulfonamide (32/32a) using the conditions already described for the conversion of (23) to (4a) in Equation 6b (Equation 7g). The thiol (32) or aniline (32a) is then converted to (4b/4e) using the method already described for the conversion of (24) to (4a) in Equation 6d (Equation 7h).
Most sulfonamides of Formula (4b) (R.sub.1 and R.sub.4 as previously defined) can also be prepared by synthetic routes analogous to that described for R.sub.1 .dbd.R.sub.4 .dbd.CH.sub.3 in Examples 9 through 16.
Sulfonamides of Formula (4c) can be prepared by the method shown in Equation 8. ##STR22## where R.sub.1 is as previously defined; R.sub.5 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or CH.sub.2 C(O)NR.sub.a R.sub.b ; R.sub.a and R.sub.b are as previously defined; W.sub.1 is O or S; M.sub.2 is Na or K; R.sub.6 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.3 -C.sub.4 cycloalkyl, cyclopropylmethyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 haloalkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.4 haloalkynyl, C.sub.2 -C.sub.4 alkoxyalkyl, or C.sub.2 -C.sub.4 aminoalkyl; and R.sub.7 is C.sub.1 -C.sub.4 alkyl substituted with W.sub.1 R.sub.6.
The starting nitrobenzenes (33) are either known in the art or may be made by a wide variety of methods known in the art. Some of these methods include the nitration (for a review, see G. Lehmann, H. Eichmann "Formation of Carbon-Nitrogen Bonds" in Preparative Organic Chemistry, G. Hilgetag, A. Martini ed., Wiley-Interscience, New York, 1972) of the coupling product obtained from reaction of the appropriate halide with diphenylcuprate (for a review, see G. H. Posner "Substitution Reactions Using Organo-copper Reagents" in Organic Reactions, Vol. 22, W. G. Dauben ed., Wiley, New York, 1975).
Another method is the Friedel-Crafts acylation of benzene with the appropriate acid halide or anhydride (for a review, see G. A. Olah, Friedel-Crafts and Related Reactions, Volumes I-IV, Wiley-Interscience, New York, 1963-1965), followed by reductive removal of the carbonyl oxidation (for a review, see C. Bischoff, P.-G. Dietrich, E. Hoft, D. Murowski, "Formation of Carbon-Hydrogen Bonds" in Preparative Organic Chemistry, G. Hilgetag, A. Martini ed., Wiley-Interscience, New York, 1972) and then nitration.
Still another method involves conversion of the appropriate 4-nitrobenzyl alcohols, aldehydes, or ketones to their mono or difluoro alkyl homologues using the conditions reviewed by G. A. Boswell, Jr., W. C. Ripka, R. M. Scribner, C. W. Tullock, "Fluorination by Sulfur Tetrafluoride" and C. M. Sharts, W. A. Sheppard "Modern Methods to Prepare Monofluoroaliphatic Compounds" in Organic Reactions, Vol. 21, W. G. Dauben ed., Wiley, New York, 1974).
The nitrobenzene (33) is reduced to the aniline (34) using the conditions already described for the conversion of (12) to (13) in Equation 4d (Equation 8a).
The aniline (34) in a suitable solvent such as benzene is treated with at least one equivalent of acetic anhydride and heated at reflux for 8-24 hours. The reaction mixture is cooled, and if the acetanilide (35) crystallizes, it is collected and dried. If it does not crystallize, the benzene solution is washed with 1N hydrochloric acid and aqueous sodium bicarbonate solution, dried over magnesium sulfate, and filtered. Evaporation of the solvent leaves the acetanilide (35) (Equation 8b).
The acetanilide (35) is then nitrated using the general conditions reviewed by G. Lehmann and H. Teichmann (op.cit.) to give nitroacetanilide (36) (Equation 8c).
A slurry of acetanilide (36) in 1N hydrochloric acid is heated at reflux until all of the solid dissolves. The solution is then made slightly basic with sodium bicarbonate and is extracted with dichloromethane. The dichloromethane extracts are dried over sodium sulfate and filtered. Evaporation of the solvent leaves the aniline (37) (Equation 8d).
Many of the substituents described within R.sub.7 are prepared from aniline (37) having an R.sub.5 substituent containing a displaceable halogen atom at the position where the substituents W.sub.1 R.sub.6 is to be placed. Thus the halide (37) in a suitable solvent such as N,N-dimethylformamide is treated with a little more than one equivalent of the appropriate sodium or potassium salt (38).
The mixture is held at 20.degree.-100.degree. C. for 1-8 hours. The solvent is then evaporated, and the residue is partitioned between water and dichloromethane. The dichloromethane solution is dried over sodium sulfate and filtered. Evaporation leaves the desired compound (39) (Equation 8e).
The aniline (39/37) is then diazotized and subjected to the Sandmeyer reaction according to the general experimental procedure of G. T. Morgan and E. A. Coulson, J. Chem. Soc. 1929, 2551 to give nitrile (40/40a) (Equation 8f).
A suspension of the nitrile (40/40a) in 75-80% aqueous sulfuric acid is heated at 95.degree.-100.degree. C. for 2-5 hours. Then over 1-2 hours and at a temperature of 80.degree.-100.degree. C. 1.5-2.5 equivalents of sodium nitrite is added in small portions. The heating is continued 0.5-1 hour longer, then the mixture is cooled and poured onto excess ice. If the carboxylic acid (41/41a) crystallizes, it is collected, rinsed with ice water and dried. If it does not crystallize, the aqueous mixture is extracted with dichloromethane. The dichloromethane solution is extracted with aqueous 10% sodium bicarbonate solution. The aqueous extract is made acidic with concentrated hydrochloric acid. If the carboxylic acid (41/41a) then crystallizes, it is collected, rinsed with ice water and dried. If it does not crystallize, the aqueous solution is extracted with ether. The ether extracts are dried over magnesium sulfate and filtered. Evaporation of the solvent leaves carboxylic acid (41/41a) (Equation 8g).
By use of the methods previously described, carboxylic acid (41) can be converted to sulfonamide (4c) and likewise (41a) gives (4c') (Equation 8h).
In the case where R.sub.7 substituents of sulfonamide (4c) are incompatible with the strongly acidic conditions described in Equation 8g, an alternative scheme is used.
Sulfonamide of Formula (4c') wherein R.sub.5 is C.sub.1 -C.sub.4 alkyl substituted with Cl, Br or I in a suitable solvent such as acetonitrile is treated with one equivalent of tert-butyldimethylsilyl chloride in the presence of a mild base such as pyridine at 15.degree.-25.degree. C. for 1-8 hours. When the reaction is judged complete by thin layer chromatography the mixture is poured onto ice water. If the silylsulfonamide crystallizes, it is collected, rinsed with water and dried. If not, the aqueous solution is extracted with ether. The ether extracts are dried and concentrated to furnish the silylsulfonamide of (4c') (Equation 8i).
A stirred solution of the silylsulfonamide of (4c') in a solvent such as DMF is treated at 0.degree.-80.degree. C. with at least one equivalent of (38) for 1-8 hours. When the reaction is judged complete by thin layer chromatography the mixture is poured onto ice water and the reaction is worked up as described in the previous paragraph (Equation 8j).
The silylsulfonamide of (4c) can then be converted directly into sulfonylurea (I) using the same conditions described in Equation 3, with the exception that tetra-n-butyl ammonium fluoride is used as base in lieu of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).
Sulfonamides of Formula (4) where R.sub.2 contains sulfinyl or sulfonyl groups can be prepared by peracid oxidation of the corresponding mercapto sulfonamides using methods analogous to those described for the preparation of sulfinyl sulfonamides of Formula (4d, n=1) and sulfonyl sulfonamides of Formula (4d, n=2) in Equation 9 (vide infra).
For example, the sulfinyl sulfonamides of Formula (4d, n=1) and sulfonyl sulfonamides of Formula (4d, n=2) can be prepared from the corresponding thio sulfonamides of Formula (4b) as shown in Equation 9. ##STR23## where R.sub.1 and R.sub.4 are as previously defined, except that R.sub.4 cannot be alkylthioalkyl or haloalkylthioalkyl, and n is 1 or 2.
To prepare the sulfinyl sulfonamides of Formula (4d, n=1) a solution of one equivalent of a peracid, such as 3-chloroperoxybenzoic acid, in an inert solvent, such as dichloromethane, is added to a stirred solution of the appropriate thio sulfonamide (4b) in an inert solvent, such as a mixture of dichloromethane and tetrahydrofuran, at 0.degree.-5.degree. C. The mixture is then warmed to 20.degree.-40.degree. C. When thin layer chromatography has revealed the sulfonamide (4b) to have been oxidized, the mixture is washed in turn with 5% aqueous sodium sulfite solution, saturated aqueous sodium bicarbonate solution, water, and brine, and then dried (MgSO.sub.4). Evaporation of the solvent then leaves the sulfinyl sulfonamide of Formula (4d, n=1).
To prepare sulfonyl sulfonamides of Formula (4d, n=2) a solution of more than two equivalents (only two equivalents when R.sub.4 is alkenyl or alkynyl) of a peracid, such as 3-chloroperoxybenzoic acid, in an inert solvent, such as 1,2-dichloroethane, is added to a stirred mixture of the appropriate thio sulfonamide (4b) in an inert solvent, such as 1,2-dichloroethane, containing 1-5 mol% of a free radical inhibitor, such as 4,4-thiobis(6-tert-butyl-m-cresol). The mixture is heated to 50.degree.-80.degree. C. When thin layer chromatography shows the thio sulfonamide (4b) and intermediate sulfinyl sulfonamide (4d, n=1) to have been consumed, the mixture is cooled and diluted with tetrahydrofuran to maintain sulfonamide solubility. Using the same work up method as already described for the preparation of sulfinyl sulfonamides (4d, n=1), one obtains the sulfonyl sulfonamides of Formula (4d, n=2).
Sulfonamides of Formula (4d) where R.sub.4 is alkylthioalkyl or haloalkylthioalkyl and n is 1 or 2 can be prepared from the homologous sulfonamides of Formula (4d) having a R.sub.4 monohaloalkyl substituent with a displaceable halogen atom at the position where the alkylthioalkyl or haloalkylthioalkyl group is to be placed. These monohaloalkyl sulfonamides are first closed to the corresponding saccharins by use of DBU as previously described for the preparation of 6-benzyloxysaccharin. The halogen atom is then replaced with the appropriate alkylthio or haloalkylthio group using the displacement conditions previously described for the conversion of halide (37) to thioether (39) in Equation 8. When the appropriate haloalkylthiolate reagent is unstable to self-condensation, the corresponding hydroxy-, carbonyl-, and/or carboxy-containing alkylthiolate can be used. After formation of the thioether bridge, these oxygen-containing groups can be converted to the desired halogen substitution pattern by use of a wide variety of methods known in the art. Finally, the saccharins are opened to the desired sulfonamides of Formula (4d) where R.sub.4 is alkylthioalkyl or haloalkylthioalkyl and n is 1 or 2 by the method already described for the conversion of (23) to (4a) in Equation 6b.
Sulfonyl isocyanates (1) are prepared from the corresponding sulfonamides (4) with compatible R.sub.2 substituents by one of the following two general methods. ##STR24## where R.sub.1 and R.sub.2 are as previously defined.
The sulfonamide (4) and an alkyl isocyanate (e.g., n-butyl isocyanate) in xylene or other solvent boiling above 135.degree. C. are mixed in the presence or absence of a catalytic amount of 1,4-diaza[2.2.2]bicyclooctane (DABCO) and heated to 135.degree.-140.degree. C. After 5-60 minutes phosgene is slowly added to the heated mixture at such a rate that the temperature remains between 133.degree.-135.degree. C. When the consumption of phosgene has ceased, the mixture is cooled and filtered to remove insoluble material. Finally, the solvent, alkyl isocyanate, and excess phosgene are evaporated, leaving the sulfonyl isocyanate (1).
If desired, the alkyl isocyanate-sulfonamide adduct can be made and isolated before reaction with the phosgene. In this case, the sulfonamide (4), alkyl isocyanate, and anhydrous base (e.g., K.sub.2 CO.sub.3) in a polar, aprotic solvent (e.g., acetone, butanone, or acetonitile) are mixed and heated under reflux for 1 to 6 hours. The reaction mixture is then diluted with water, and the pH is adjusted to about 3 with acid (e.g. HCl, H.sub.2 SO.sub.4). The adduct is filtered out and dried, and then reacted with phosgene as described above. This procedure modification is especially useful when sulfonamide (4) is high melting and has low solubility in the phosgenation solvent.
Sulfonyl isocyanates (1) can also be prepared by the following method. ##STR25## where R.sub.1 and R.sub.2 are as previously defined.
The sulfonamide (4) is heated at reflux in an excess of thionyl chloride. The reaction is continued until the sulfonamide protons are no longer detectable in the proton magnetic resonance spectrum. From 16 hours to 5 days is typically sufficient for complete conversion to the thionylamide (42) (Equation 11a).
The thionyl chloride is evaporated and the residue is treated with an inert solvent (e.g. toluene) containing at least one equivalent (typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine (typically 0.1 equivalent) is added, and the mixture is heated to about 60.degree.-140.degree. C. with 80.degree.-100.degree. preferred. Conversion to the isocyanate (1) is usually substantially complete within 15 minutes to 3 hours (Equation 11b). The mixture is then cooled and filtered, and the solvent is evaporated, leaving the sulfonyl isocyanate (1).
The heterocyclic amines of Formula (2) below are either known, disclosed in this application, or can be prepared by obvious methods by one skilled in the art. ##STR26##
For a review of the synthesis and reactions of 2-amino and 2-methylaminopyrimidines (2, Z.dbd.CH) see The Chemistry of Heterocyclic Compounds, Vol. 16, Wiley-Interscience, New York (1962). For a review of the synthesis and reactions 2-amino- and 2-methylamino-s-triazines (2, Z.dbd.N) see The Chemistry of Heterocyclic Compounds, Vol. 13, Wiley-Interscience, New York (1959), F. C. Schaefer, U.S. Pat. No. 3,154,537 and F. C. Schaefer and K. R. Huffman, J. Org. Chem., 28, 1812 (1963).
In some cases, heterocycles of Formula (2) may be more easily prepared with R being H than with R being CH.sub.3. Many heterocycles (2, R.dbd.CH.sub.3) can be prepared from the corresponding heterocycles (2, R.dbd.H) by one or more of the following two methods. ##STR27## where A is as previously defined.
In this method, a solution or slurry of the appropriate heterocycle (2, R.dbd.H) in a suitable aprotic solvent (e.g., tetrahydrofuran, dioxane, glyme) at 0.degree.-30.degree. C. is treated with two equivalents of sodium hydride. After gas evolution ceases, the reaction mixture is treated with one equivalent of dimethyl carbonate and stirred at 20.degree.-30.degree. C. for 8 to 24 hours to provide a suspension of the sodium salt (43) (Equation 12a).
The reaction mixture containing (43) is treated with at least two equivalents of iodomethane and then heated at 60.degree.-80.degree. C. for 8 to 24 hours. The mixture is cooled and filtered, and the solvent is evaporated. The residue is taken up in dichloromethane, washed with water, and the solvent is evaporated, leaving the N-methyl carbamate (44, R.dbd.CH.sub.3) (Equation 12b).
The carbamate (44, R.dbd.CH.sub.3) is dissolved in anhydrous, alcohol-free chloroform saturated with propylene gas. Slightly more than one equivalent (typically 1.1-1.2 equivalents) of iodotrimethylsilane) is added and the stirred solution is heated at 50.degree.-60.degree. C. for 2 to 4 hours. The mixture is cooled and two equivalents of methanol is added. The solvent is evaporated and the residue is taken up in methanol. The mixture is carefully neutralized with 10% sodium methoxide in methanol, and then the solvent is evaporated. The residue is triturated with ice water. If a precipitate forms, it is filtered out, rinsed with ice water and dried to provide (2, R.dbd.CH.sub.3). If no precipitate forms, the solution is saturated with sodium chloride and extracted with ethyl acetate. Evaporation of the solvent leaves heterocycle (2, R.dbd.CH.sub.3) (Equation 12c).
Alternatively, the following two-step procedure is useful in many cases. ##STR28## where A is as previously defined.
A solution of the amine (2, R.dbd.H) in concentrated hydrochloric acid is treated with sodium nitrite solution and the chloro compound (45) is isolated in the usual manner by filtration of the acidic solution (Equation 13a). A representative procedure is described by Bee and Rose in J. Chem. Soc. C. 1966, 2031, for the case in which Z.dbd.CH, and X.dbd.Y.dbd.OCH.sub.3.
The heterocycle (45) is then treated with at least two equivalents of methylamine in a suitable inert solvent (e.g. tetrahydrofuran, glyme, or diglyme) at a temperature between 20.degree. and 80.degree. C. for 1-18 hours (Equation 13b). The reaction mixture is then cooled and filtered. Evaporation of the solvent leaves (2, R.dbd.CH.sub.3) contaminated with a little CH.sub.3 NH.sub.3.sup.+ Cl.sup.- salt. The product may be purified by trituration with ice water or by dissolution in dichloromethane, followed by washing with a small amount of water, drying, and evaporation of solvent. Further purification may be accomplished by recrystallization or column chromatography on silica gel.
As an alternative to the methods already described in which the sulfonamides of Formulae (4a), (4b), and (4e) are fully elaborated prior to construction of the urea bridge of compounds of Formula I, many compounds of Formula Ia may be prepared by the method described in Equation 14. ##STR29## where R.sub.1, X, X.sub.1, Y and Z are as previously defined; W is S, O or NR.sub.b ; R.sub.b is as previously defined; R.sub.8 is C.sub.4 -C.sub.6 cycloalkylalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 haloalkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 haloalkynyl, C.sub.2 -C.sub.8 alkoxyalkyl, C.sub.2 -C.sub.4 haloalkoxyalkyl, C.sub.2 -C.sub.8 alkylthioalkyl, C.sub.2 -C.sub.4 haloalkylthioalkyl, C.sub.2 -C.sub.4 cyanoalkyl, CH.sub.2 C(O)CH.sub.3, CH.sub.2 CH.sub.2 C(O)CH.sub.3 or C.sub.1 -C.sub.6 alkyl.
In this method a solution of the appropriate compound of Formula (46) in a polar solvent such as a mixture of acetonitrile and N,N-dimethylformamide is treated with two equivalents of a strong base such as sodium methoxide or sodium hydride with catalytic methanol followed by a little more than one equivalent of the appropriate alkylating, alkenylating, or alkynylating agent (47). The mixture is held at 20.degree.-60.degree. C. for 2-24 hours. Then the mixture is poured into excess hydrochloric acid. If the compound of Formula Ia mixture is extracted with dichloromethane, and evaporation of the solvent leaves the compound of Formula Ia. The compounds of Formula (46) are in turn prepared by coupling the appropriate sulfonamides of Formulae (4a, 4b or 4e) with the appropriate heterocyclic phenyl carbamates of Formula (5, R.dbd.H) according to the general method described for Equation 3.
Many of the compounds of Formula Ia where R.sub.8 is alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxyalkyl, haloalkoxyalkyl, cyanoalkyl, --CH.sub.2 C(O)CH.sub.3, or --CH.sub.2 CH.sub.2 C(O)CH.sub.3 and W is S(O) or S(O).sub.2 can be made by oxidation of the corresponding compounds of Formula Ia where W is S using methods similar to those already described for the conversion of (4b) to (4d) in Equation 9.
Compounds of Formula I where R.sub.2 contains a carbonyloxy, carbamoyloxy, phosphoryloxy, sulfonyloxy, silyloxy, or phosphorylthio group are prepared from the corresponding compounds of Formula I where R.sub.2 contains a hydroxyl or thiol group by use of a wide variety of methods known in the art.
The following examples further illustrate the synthesis of this invention.

EXAMPLE 1
Methyl 4-ethoxy-2-hydroxybenzoate
Hydrogen chloride was bubbled into a stirred solution of 4-ethoxy-2-hydroxybenzoic acid (10.10 g, 0.554 mol) in methanol (2000 mL) until the solution was saturated. The solution was heated under reflux for 3 days and then cooled to 15.degree. C. This caused the product to crystallize out. The crystals were collected, rinsed with methanol and hexanes, and dried. Methyl 4-ethoxy-2-hydroxybenzoate was obtained as a pale amber solid (49.3 g) melting at 77.degree.-78.degree. C.
PMR (CDCl.sub.3, 90 MHz): .delta.11.90 (slightly broadened s, 1H, OH); 7.76 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 6.35-6.55 (m, 2H, other aryl H's); 4.06 (q, 2H, OCH.sub.2 CH.sub.3); 3.89 (s, 3H, OCH.sub.3): 1.41 (t, 3H, OCH.sub.2 CH.sub.3). IR (Nujol); 3130 (broad, w, OH): 1668 (s, C.dbd.O) cm.sup.-1. More product was obtained by reworking the mother liquor.
EXAMPLE 2
Methyl 2-[(dimethylamino)thioxomethoxy]-4-ethoxybenzoate
Triethylamine (76.6 mL, 0.550 mol) was added via syringe to a stirred solution of methyl 4-ethoxy-2-hydroxybenzoate (49.3 g, 0.251 mol), 4-dimethylaminopyridine (3.06 g, 0.025 mol), and dimethylthiocarbamoyl chloride (54.4 g, 0.440 mol) in dry dichloromethane (411 mL). The reaction solution was heated at reflux three days and then allowed to stand at room temperature overnight. It was washed with hydrochloric acid (1N, 3.times.300 mL) and then dried (MgSO.sub.4) and filtered. Rotary evaporation of the solvent left crude product (95.2 g) as a brown oil. This was applied to a column of silica gel an eluted with 2:1 followed by 1:1 hexanes-ether. Fractions containing product (R.sub.f =0.43, 1:1 hexanes-ether, UV) were rotary evaporated to give partially purified product (60.2 g) as a yellowish solid. Further purification was achieved by additional column chromatography employing a greater silica gel to sample ratio. Finally, the doubly chromatographed product (48.7 g including 7.4 g from another similar run) was recrystallized from boiling methanol (3 mL/g). After cooling in an ice bath, the crystals were collected, rinsed with ice-cold methanol and dried. Methyl 2-[(dimethylamino)thioxomethoxy]-4-ethoxybenzoate was obtained as large white prisms (46.1 g) melting at 77.degree.-79.degree. C.
PMR (CDCl.sub.3, 200 MHz): .delta.7.96 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 7.81 (dd, 1H, H para to OCSN); 6.62 (d, 1H, H ortho to OCSN); 4.08 (q, 2H, OCH.sub.2 CH.sub.3); 3.81 (s, 3H, CO.sub.2 CH.sub.3); 3.47 (s, 3H, NCH.sub.3); 3.40 (s, 3H, NCH.sub.3); 1.42 (t, 3H, OCH.sub.2 CH.sub.3). IR (Nujol): 1715 cm.sup.-1 (vs, C.dbd.O).
EXAMPLE 3
Methyl 2-[(dimethylamino)carbonylthio]-4-ethoxybenzoate
Methyl 2-[(dimethylamino)thioxomethoxy]-4-ethoxybenzoate (28.3 g, 0.100 mol) was heated under nitrogen at 220.degree. C. for 1.5 hours. Thin layer chromatography (6:3:1 CH.sub.3 Cl.sub.2 -hexanes-ether, UV) showed a very faint spot at a R.sub.f of 0.63 (starting material) and a very intense spot at a R.sub.f of 0.35 (product). In this case the crude product was used in the next reaction step without further characterization or purification.
Crude product from a similar but smaller scale run was chromatographed on a column of silica gel using 4:1 ether-hexanes as eluant. Fractions containing product (R.sub.f =0.40, same solvent, UV) were rotary evaporated to give an oil that slowly crystallized. This was dissolved in a little dichloromethane, diluted with 1-chlorobutane, seeded, and rotary evaporated. The residue was collected, rinsed with hexanes, and dried. Methyl 2-[(dimethylamino)carbonylthio]-4-ethoxybenzoate was obtained as white prisms melting at 65.degree.-67.degree. C. PMR (CDCl.sub.3, 200 MHz): .delta.7.93 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 7.16 (d, 1H, H ortho to SCON); 6.89 (dd, 1H, H para to SCON); 4.08 (q, 2H, OCH.sub.2 CH.sub.3); 3.84 (s, 3H, CO.sub.2 CH.sub.3); 3.09 (broad s, 6H, N(CH.sub.3).sub.2); 1.42 (t, 3H, OCH.sub.2 CH.sub.3). IR (Nujol): 1730 (s, ester C.dbd.O); 1680 (s, carbonyl C.dbd.O) cm.sup.-1.
EXAMPLE 4
Methyl 4-ethoxy-2-mercaptobenzoate
Methanolic sodium methoxide (4.9M, 22.4 mL, 0.11 mol) was added via syringe to a solution of methyl 2-[(dimethylamino)carbonylthio]-4-ethoxybenzoate (crude, ca. 28.3 g, 0.10 mol) in methanol (100 mL) under nitrogen. The reaction mixture was heated at reflux for 30 minutes, then cooled with the aid of a water bath. Rotary evaporation yielded a solid. This was partitioned between dichloromethane (100 mL) and water (100 mL). The aqueous layer was washed with dichloromethane (3.times.40 mL), acidified to pH <1 with concentrated hydrochloric acid, and then extracted with dichloromethane (3.times.40 mL). These dichloromethane extracts were combined, dried (Na.sub.2 SO.sub.4), and filtered. Rotary evaporation yielded methyl 4-ethoxy-2-mercaptobenzoate as an oil (18.4 g) that on standing formed a crystalline solid melting at 42.degree.-44.degree. C. PMR (CDCl.sub.3, 200 MHz): .delta.7.97 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 6.78 (d, 1H, H ortho to SH); 6.64 (dd, 1H, H para to SH); 5.06 (s, 1H, SH); 4.05 (q, 2H, OCH.sub.2 CH.sub.3); 3.88 (s, 3H, CO.sub.2 CH.sub.3); 1.42 (t, 3H, OCH.sub.2 CH.sub.3). IR (Nujol): 1686 (vs, C.dbd.O) cm.sup.-1.
EXAMPLE 5
Methyl 2-(chlorosulfonyl)-4-ethoxybenzoate
Hydrogen peroxide (30%, 9.79M, 30.7 mL, 300 mmol) was added dropwise to a stirred solution of methyl 4-ethoxy-2-mercaptobenzoate (18.2 g, 85.7 mmol) and sodium formate (11.7 g, 172 mmol) in formic acid (171.4 mL). Through the use of an ice bath, the internal temperature was held to 40.degree.-50.degree. C. during the first half of the hydrogen peroxide addition and 45.degree.-50.degree. C. during the second half of the addition. After completion of the addition and cessation of the exothermic reaction, the mixture was heated at 45.degree.-55.degree. C. for two hours. The excess hydrogen peroxide was destroyed with sodium sulfite, the solution was filtered, and the solvent was rotary evaporated. The residue was slurried in toluene and rotary evaporated. The process was repeated to give the sodium sulfonate salt as a moist white crystalline solid (21.7 g).
Without further purification or characterization, the sodium sulfonate salt was added portionwise to stirred thionyl chloride (150 mL, 2.1 mmol). Anhydrous N,N-dimethylformamide (1.0 mL, 13 mmol) was added slowly, and the reaction mixture was heated at reflux overnight. The reaction mixture was then rotary evaporated. Dichloromethane (150 mL) was added, and the solvent was again evaporated. The residue was partitioned between ether (100 mL) and ice water (100 mL). The aqueous layer was extracted with ether (2.times.50 mL). The combined ether solutions were washed with water (50 mL), saturated aqueous sodium bicarbonate solution (2.times.50 mL), dried (MgSO.sub.4), and filtered. Rotary evaporation of the solvent left methyl 2-(chlorosulfonyl)-4-ethoxy-benzoate as pale orange oil (22.5 g) that crystallized on scratching. The crystalline solid melted at 45.degree.-48.degree. C. PMR (CDCl.sub.3, 200 MHz): .delta.7.76 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 7.65 (d, 1H, H ortho to SO.sub.2 Cl); 7.21 (dd, 1H, H para to SO.sub.2 Cl); 4.16 (q, 2H, OCH.sub.2 CH.sub.2); 3.96 (s, 3H, CO.sub.2 CH.sub.3); 1.48 (t, 3H, OCH.sub.2 CH.sub.3). IR (Nujol0: 1722 (vs, C.dbd.O) cm.sup.-1.
EXAMPLE 6
Methyl 2-(aminosulfonyl)-4-ethoxybenzoate
Liquified ammonia (4.4 mL, 180 mmol) was added to a stirred solution of methyl 2-(chlorosulfonyl)-4-ethoxybenzoate (22.1 g, 79.3 mmol) in dichloromethane (221 mL) at -70.degree. C. The reaction mixture was allowed to warm to -10.degree. C. and was held at this temperature for 30 minutes. The mixture was then poured into water (221 mL). More water and dichloromethane were used for rinsing, and tetrahydrofuran (ca. 40 mL) was also added. The layers were shaken and separated, and the aqueous layer was extracted with dichloromethane (2.times.221 mL). The combined dichloromethane solutions were washed with water (221 mL), and the aqueous wash was back-extracted with dichloromethane (ca. 120 mL). The combined dichloromethane solutions were dried (Na.sub.2 SO.sub.4), and filtered. Rotary evaporation of the solvent left crude product as an off-white crystalline solid (18.1 g). This was dissolved in hot methanol (ca. 200 mL) and hot filtered. The solution was boiled down to a volume corresponding to 3 mL/g methanol. After seeding and cooling with the aid of an ice bath, the crystals were collected, rinsed with ice-cold methanol and hexanes, and dried. Methyl 2-(aminosulfonyl)-4-ethoxybenzoate (15.3 g) was obtained as white crystalline needles melting at 146.degree.-148.degree. C. PMR (CDCl.sub.3, 200 mHz): .delta.7.91 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 7.68 (d, 1H, H ortho to SO.sub.2 NH.sub.2); 7.04 (dd, 1H, H para to SO.sub.2 NH.sub.2); 5.91 (broad s, 2H, NH.sub.2); 4.14 (q, 2H, OCH.sub.2 CH.sub.3); 3.95 (s, 3H, CO.sub.2 CH.sub.3); 1.45 (t, 3H, OCH.sub.2 CH.sub.3). IR (Nujol): 3348 (m, NH); 3241 (m, NH); 1692 (s, C.dbd.O) cm.sup.-1.
EXAMPLE 7
Methyl 4-ethoxy-2-(isocyanatosulfonyl)benzoate
A solution of methyl 2-(aminosulfonyl)-4-ethoxybenzoate (7.56 g, 29.2 mmol), n-butyl isocyanate (3.29 mL, 29.2 mmol), and 1,4-diaza[2.2.2]bicyclooctane (0.13 g, 1.2 mmol) in mixed xylenes was heated at reflux for 10 minutes. Phosgene was then added at such a rate that the internal temperature stayed at 133.degree. C. or above. When consumption of phosgene ceased, the solution was cooled to room temperature and then filtered under nitrogen. Rotary evaporation gave methyl 4-ethoxy-2-(isocyanatosulfonyl)benzoate as a cloudy yellow oil (8.2 g). This was used immediately without further purification or characterization.
EXAMPLE 8
Methyl 2-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-4-ethoxybenzoate
To a slurry of 4,6-dimethoxy-1,3,5-triazin-2-amine (0.46 g, 2.9 mmol) in dry dichloromethane (5 mL) was added a solution of methyl 4-ethoxy-2-(isocyanatosulfonyl)benzoate (crude, ca. 1.2 g, 4.2 mmol) in dichloromethane (5 mL). The reaction mixture was heated at reflux for 1.5 hours, during which time the solid dissolved. On stirring at room temperature overnight a new solid formed. The solvent was rotary evaporated, leaving the crude product as a white solid (1.5 g). This was dissolved in warm 1,2-dichloroethane and chromatographed on a column of silica gel using as eluant 15:1, 10:1, and finally 7:1 dichloromethane-ether, all containing 2 mL/L acetic acid. The appropriate fractions were diluted with toluene and rotary evaporated to give a solid. This was dissolved in minimal warm dichloromethane, diluted with 1-chlorobutane, and rotary evaporated to give a crystalline solid. This was slurried in hexanes, collected, rinsed with 1:1 1-chlorobutane-hexanes and hexanes, and dried. The product was obtained as a white crystalline powder (0.98 g) melting at 181.degree.-183.degree. C. PMR (CDCl.sub.3, 200 MHz): .delta.12.15 (slightly broadened s, 1H, SO.sub.2 NHCO); 7.89 (d, 1H, H ortho to SO.sub.2 NH); 7.77 (d, 1 H, H ortho to CO.sub.2 CH.sub.3); 7.45 (slightly broadened s, 1H, CONH-Het); 7.11 (dd, 1H, H para to SO.sub.2 NH); 4.17 (q, 2H, OCH.sub.2 CH.sub.3); 4.12 (s, 6H, Het-OCH.sub.3); 3.90 (s, 3H, CO.sub.2 CH.sub.3); 1.46 (t, 3H, OCH.sub.2 CH.sub.3). IR (Nujol): 1730 (vs, ester C.dbd.O); 1715 (s, urea C.dbd.O) cm.sup.-1.
EXAMPLE 9
4-(Methylthio)-2-nitrobenzoic acid
4-Amino-2-nitrobenzoic acid (20.0 g, 110 mmol) was added to aqueous sulfuric acid (32.8 mL H.sub.2 O+24.0 mL conc. H.sub.2 SO.sub.4). The stirred mixture was heated until all of the aniline dissolved, and then was plunged into an ice bath to precipitate the anilinium salt as suspension of very small crystals. Portions of aqueous sodium nitrite (8.8 g, 128 mmol in 18.4 mL H.sub.2 O) were then added over one hour to the stirred reaction mixture maintained at -50.degree. to 0.degree. C.
The diazotization mixture was then poured portionwise into a mixture of sodium hydroxide (24.4 g, 610 mmol), methanethiol (33.6 mL, 605 mmol); cupric sulfate (17.6 g, 110 mmol), and sodium acetate (55.2 g, 673 mmol) in 140 mL of water cooled with the aid of an ice bath. The addition was exothermic and accompanied by copious gas evolution. A suspension of tan-yellow solid formed. The mixture was heated to 60.degree. C., and then was allowed to cool to room temperature.
Dichloromethane (200 mL) and tetrahydrofuran (20 mL) were stirred in. Concentrated hydrochloric acid was added to bring the pH below 1. The mixture was suction filtered through Celite.RTM., with additional dichloromethane used for rinsing. The layers were separated, and the aqueous layer was extracted with dichloromethane (2.times.50 mL). The combined dichloromethane solutions were dried (Na.sub.2 SO.sub.4) and suction filtered through Celite.RTM.. The solvent was rotary evaporated. The residue was dissolved in minimal acetone, diluted with toluene, and evaporated. The residue was dissolved in minimal acetone, diluted with toluene, and evaporated. The process was repeated to leave crude 4-(methylthio)-2-nitrobenzoic acid as an orange solid (20.4 g) melting at 165.degree.-168.degree. C. This was used in the next step without further purification.
PMR (DMSO-d.sub.6, 200 MHz): .delta.13.6 (very broad s, 1H, CO.sub.2 H); 7.83 (d, 1H, H ortho to CO.sub.2 H); 7.76 (d, 1H, H ortho to NO.sub.2); 7.58 (dd, 1H, H para to NO.sub.3); 2.58 (s, 3H, SCH.sub.3). IR (Nujol): 2800 (very broad, m, OH); 1675 (s, C.dbd.O) cm.sup.-1.
EXAMPLE 10
Methyl-4-(methylthio)-2-nitrobenzoate
To a stirred solution of 4-(methylthio)-2-nitrobenzoic acid (24.4 g, 114 mmol) in dry pyridine (265 mL) maintained at 5.degree. C. under nitrogen was added p-toluenesulfonyl chloride (43.6 g, 229 mmol). After one hour and with continued cooling with the aid of an ice bath, dry methanol (6.2 mL, 153 mmol) was added. After the exothermicity subsided, another portion of methanol (4.1 mL, 101 mmol) was added, and the ice bath was removed.
The reaction solution was stirred at room temperature for one hour and then poured into ice water (1060 mL). Ether (530 mL) was stirred in, and the layers were separated. The aqueous layer was extracted with ether (2.times.530 mL). The combined ether solutions were washed with 10% aqueous sodium hydroxide solution (2.times.530 mL), dried (MgSO.sub.4), and filtered. The solvent was rotary evaporated. The residue was taken up in toluene, which was subsequently rotary evaporated. This process was repeated once more to give a thick brown oil.
This oil was chromatographed on a column of silica gel using mixtures of hexanes and ether (first 2:1 then 3:2) as eluting solvents. Fractions containing product (R.sub.f =0.38, UV 2:1 hexanes-ether) were evaporated to leave a yellow solid. This was dissolved in minimal warm 1-chlorobutane, diluted with hexanes to saturation, and seeded. After crystallization was complete, the mixture was evaporated. The residue was slurried in hexanes, collected, rinsed with hexanes, and dried. Methyl 4-(methylthio)-2-nitrobenzoate was obtained as pale yellow needles (11.6 g) melting at 57.degree.-59.degree. C.
PMR(CDCl.sub.3, 200 MHz): .delta.7.71 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 7.55 (d, 1H, H ortho to NO.sub.2); 7.41 (dd, 1H, H para to NO.sub.2); 3.90 (s, 3H, CO.sub.2 CH.sub.3); 2.56 (s, 3H, SCH.sub.3). IR (Nujol): 1709 (vs, C.dbd.O) cm.sup.-1.
EXAMPLE 11
Methyl 2-amino-4-(methylthio)benzoate
A mixture of methyl 4-(methylthio)-2-nitrobenzoate (11.3 g, 49.7 mmol) and 5% platinum sulfide on carbon catalyst (0.7 g) in methyl acetate (40 mL) was hydrogenated at 750 psi and 75.degree. C. until hydrogen uptake ceased. The mixture was filtered through Celite.RTM., and the filtrate solvent was rotary evaporated, leaving methyl 2-amino-4-(methylthio)benzoate as a slightly tan crystalline solid (8.7 g) melting at 57.degree.-59.degree. C.
PMR (CDCl.sub.3, 200 MHz): .delta.7.74 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 6.50 (dd, 1H, H para to NH.sub.2); 6.44 (dd, 1H, H ortho to NH.sub.2); 5.75 (broad s, 2H, NH.sub.2); 3.85 (s, 3H, CO.sub.2 CH.sub.3); 2.46 (s, 3H, SCH.sub.3). IR (Nujol): 3422 (m, NH); 3312 (m, NH); 1650 (s, C.dbd.O) cm.sup.-1.
EXAMPLE 12
Methyl 2-(chlorosulfonyl)-4-(methylthio)benzoate
To a stirred aqueous sulfuric acid solution (7.2 mL concentrated H.sub.2 SO.sub.4 +51.6 mL H.sub.2 O) maintained at -5.degree. to 0.degree. C. was added alternately portions of a solution of methyl 2-amino-4-(methylthio)benzoate (12.8 g, 64.9 mL) in glacial acetic acid (6.4 mL) and portions of aqueous sodium nitrate (4.9 g, 71 mmol in 7.8 mL H.sub.2 O).
The diazotization mixture was then poured portionwise into a mixture of cupric chloride dihydrate (5.5 g, 32 mmol), concentrated hydrochloric acid (13.0 mL) and liquified sulfur dioxide (5.5 mL, 129 mmol) in glacial acetic acid (51.6 mL) and dichloromethane (64.6 mL) at 0.degree. C. Using dry ice-filled Dewar condensers, the coupling mixture was heated at reflux for 45 minutes.
The reaction mixture was then poured into water (ca. 400 mL) with additional dichloromethane (ca. 60 mL) used for rinsing. The layers were shaken and separated, and the aqueous layer was extracted with dichloromethane (3.times.50 mL). The combined dichloromethane solutions were washed with water (ca. 100 mL). Water (25 mL) was added to the dichloromethane solution, and with vigorous stirring sodium bicarbonate was added until foaming ceased. The mixture was diluted with water (ca. 40 mL), and the layers were separated. The dichloromethane layer was washed with water (ca. 2.times.60 mL) and dried (MgSO.sub.4). Rotary evaporation of the solvent afforded crude methyl 2-(chlorosulfonyl)-4-(methylthio)benzoate as a yellow semisolid (10.0 g). This was immediately used in the next reaction step without further purification or characterization.
EXAMPLE 13
Methyl 2-(aminosulfonyl)-4-(methylthio)benzoate
Liquified ammonia (1.7 mL, 68 mmol) was added to a stirred solution of methyl 2-(chlorosulfonyl)-4-(methylthio)benzoate (10 g, 36 mmol) in dichloromethane (100 mL) at -70.degree. C. The reaction mixture was allowed to warm to -10.degree. C. and was held at this temperature for 10 minutes. The mixture was then poured into water (100 mL). More water and dichloromethane were used for rinsing. The layers were shaken and separated, an the aqueous layer was extracted with dichloromethane (2.times.50 mL). The combined dichloromethane solutions were washed with water (100 mL), dried (Na.sub.2 SO.sub.4), and filtered through Celite.RTM.. Rotary evaporation of the solvent left crude product as a solid (9.0 g).
This was dissolved in dichloromethane and suspended on silica gel (27 g). The material was chromatographed on a column of silica gel using dichloromethane-hexanes-ether (6:3:1 then 6:2:2) as eluant. Rotary evaporation of the appropriate fractions left a solid. This was dissolved in dichloromethane, diluted with hexanes, and rotary evaporated to give a crystalline solid. This was slurried in hexanes, collected, rinsed with 1:1 1-chlorobutane-hexanes and hexanes, and dried. Methyl 2-(aminosulfonyl)-4-(methylthio)benzoate was obtained as a white crystalline powder (6.7 g) melting at 123.degree.-125.degree. C.
PMR (CDCl.sub.3, 200 MHz): .delta.7.97 (d, 1H, H ortho to SO.sub.2 NH.sub.2); 7.82 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 7.39 (dd, 1H, H para to SO.sub.2 NH.sub.2); 5.86 (s, 2H, NH.sub.2); 3.97 (s, 3H, CO.sub.2 CH.sub.3); 2.56 (s, 3H, SCH.sub.3). IR (Nujol): 3322 (m, NH.sub.2); 3245 (m, NH.sub.2); 1700 (s, C.dbd.O) cm.sup.-1.
EXAMPLE 14
Methyl 2-(isocyanatosulfonyl)-4-(methylthio)benzoate
A solution of methyl 2-(aminosulfonyl)-4-(methylthio)benzoate (5.23 g, 20.0 mmol), n-butyl isocyanate (2.25 mL, 20.0 mmol), and 1,4-diaza[2.2.2]bicyclooctane (0.09 g, 0.8 mmol) in mixed xylenes (50 mL) was heated at reflux for 10 minutes. Phosgene was then added at such a rate that the internal temperature stayed at 133.degree. C. or above. When consumption of phosgene ceased, the solution was cooled to room temperature and then filtered under nitrogen. Rotary evaporation gave methyl 2-(isocyanatosulfonyl)-4-(methylthio)benzoate as a yellow oil (6.4 g). This was used immediately without further purification or characterization.
EXAMPLE 15
Methyl 2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoate
To a slurry of 4,6-dimethoxy-1,3-pyridimin-2-amine (0.36 g, 2.32 mmol) in dry dichloromethane (4 mL) was added a solution of methyl 2-(isocyanatosulfonyl)-4-(methylthio)benzoate (crude, ca. 0.95 g, 3.3 mL) in dichloromethane (5 mL). The reaction mixture was heated at reflux for 2.5 hours, during which time a new solid formed.
On stirring at room temperature overnight a new solid formed. The mixture was diluted with a solution of 1:1 1-chlorobutane-hexanes (9 mL), and the solid was collected, rinsed with 1-chlorobutane and hexanes, and dried. The product was obtained as a white crystalline powder (0.92 g) melting at 201.degree.-202.degree. C.
PMR (CDCl.sub.3, 200 MHz): .delta.12.57 (slightly broadened s, 1H, SO.sub.2 NHCO); 8.20 (d, 1H, H ortho to SO.sub.2 NH); 7.66 (d, 1H, H ortho to CO.sub.2 CH.sub.3); 7.43 (dd, 1H, H para to SO.sub.2 NH); 7.18 (slightly broadened s, 1H, CONH-Het); 5.79 (s, 1H, Het 5-H); 4.01 (s, 6H, Het-OCH.sub.3); 3.87 (s, 3H, CO.sub.2 CH.sub.3); 2.58 (s, 3H, SCH.sub.3). IR (Nujol): 1721 (vs, ester C.dbd.O); 1698 (s, urea, C.dbd.O) cm.sup.-1.
EXAMPLE 16
1,2-Benzisothiazol-3(2H)-one-6-(methylthio)-1,1-dioxide
A solution of 1,2-benzoisothiazol-3(2H)-one-6-chloro-1,1-dioxide (10 g, 46 mmol) and potassium-tert-butoxide (13 g, 115 mmol) in N,N-dimethylformamide (100 mL) maintained at 0.degree. C. was treated with excess of methyl mercaptan for 15 minutes. The mixture was then allowed to warm to 25.degree. C. and after 2 hours at this temperature the reaction was heated to 110.degree. C. for 1 hour. After this time the mixture was allowed to cool and then was poured onto ice water. The pH was adjusted to 2 and the solid was collected by filtration. The product was obtained as a white solid (10.2 g) melting at 232.degree.-234.degree. C.
PMR (D.sub.6 -Acetone, 90 MHz): .delta.8.2-8.0 (m, 3H, aryl-H) and 3.2 (s, 3H, SCH.sub.3).
EXAMPLE 16a
1,2-Benzisothiazol-3(2H)-one-6-(methoxy)-1,1-dioxide
To a solution of 1,2-benzisothiazol-3-(2H)-one-6-chloro-1,1-dioxide (1.0 g, 4.6 mmol) in N,N-dimethylformamide (15 mL) was added in one portion 3.5 mL of 25% sodium methoxide in methanol. The mixture was warmed to 85.degree. C. and allowed to stir for 12 hours. The mixture was cooled and diluted with water (20 mL). The product was collected by filtration and washed with water. The product was obtained as light brown solid (0.88 g) melting at 266.degree.-268.degree. C.
PMR (D.sub.6 -Acetone, 90 MHz) .delta.8.0 (d, 1H), 7.8 (d, 1H), 7.6 (dd, 1H), 4.1 (s, 3H).
EXAMPLE 16b
1,2-Benzisothiazol-3(2H)-one-6-(hydroxy)-1,1-dioxide
A mixture of 1,2-benzisothiazol-3(2H)-one-6-(methoxy)-1,1-dioxide (0.66 g, 3.1 mmol) and potassium t-butoxide (0.87 g, 7.7 mmol) in N,N-dimethylformamide (8 mL) and treated with propyl mercaptan (0.42 mL, 4.65 mmol). The brown mixture was heated to 110.degree. C. for 3 hours. After cooling, the mixture was poured onto ice-water (50 mL) and acidified to pH=1 with concentrated HCl. The homogeneous solution was extracted with ethyl acetate (3.times.50 mL) and the organics were washed with water (3.times.25 mL), then brine (2.times.25 mL). The organics were dried (MgSO.sub.4) and concentrated to give a white solid (0.44 g) melting at 148.degree.-150.degree. C.
PMR (D.sub.6 -Acetone, 90 MHz) .delta.9.8 (bs, 1H+H.sub.2 O), 8.0 (d, 1H), 7.5 (m, 2H).
EXAMPLE 16c
1,2-Benzisothiazol-3(2H)-one-6-(difluoromethoxy)-1,1-dioxide
A mixture of 1,2-benzisothiazol-3-(2H)-one-6-(hydroxy)-1,1-dioxide (4.0 g, 20.0 mmol) in aqueous potassium hydroxide (3.4 g KOH in 60 mL H.sub.2 O) was added to a solution of tetra-n-butylammonium bromide (0.2 g) in methylene chloride (25 mL). The mixture was charged with Freon 22 gas and then heated at reflux for 6 hours. After cooling, the reaction was filtered and the layers were separated. The aqueous layer was acidified to pH=1 with concentrated HCl and 1.7 g of a white solid was obtained, m.p. 179.degree.-181.degree. C. The organics were concentrated and taken up in ethyl acetate (20 mL). This solution was filtered through a small pad of silica gel and the filtrate was concentrated to furnish an additional 0.7 g of product.
PMR (D.sub.6 -Acetone, 90 MHz) .delta.8.2 (d, 1H), 7.9 (d, 1H), 7.7 (dd, 1H), 7.3 (t, 1H).
EXAMPLE 16d
Ethyl 2-(aminosulfonyl)-4-(difluoromethoxy)benzoate
A solution of 1,2-benzisothiazol-3(2H)-one-6-(difluoromethoxy)-1,1-dioxide (0.8 g, 3.2 mmol) in ethanol (100 mL) was cooled to 0.degree. C. and hydrogen chloride gas bubbled into the solution for 15 minutes. The mixture was heated at reflux for 1 hour and then cooled and diluted with water (200 mL). The ethanol was evaporated and the aqueous solution was allowed to stir until the product precipitated from solution. Filtration of the precipitate furnished 0.57 g of a white solid, m.p. 96.degree.-97.degree. C.
PMR (D.sub.6 -Acetone, 90 MHz) .delta.7.9 (d, 1H), 7.8 (d, 1H), 7.4 (dd, 1H), 7.15 (t, 1H), 4.4 (q, 2H), 1.4 (t, 3H).
EXAMPLE 16e
2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-4-(difluoromethoxy)benzoic acid, ethyl ester
A mixture of ethyl 2-(aminosulfonyl)-4-(difluoromethoxy)benzoate (0.15 g, 0.51 mmol) and phenyl (4,6-dimethoxy-2-pyrimidinyl)carbamate (0.14 g, 0.51 mmol) was treated with 1,8-diazabicyclo[5.4.0]undec-7-ene (76 .mu.L, 0.6 mmol). The mixture was stirred at 25.degree. C. for 1 hour and then diluted with ice water (10 mL) and acidified with aqueous HCl (1N). Filtration of the precipitate provided 0.19 g of product, m.p. 146.degree.-149.degree. C.
PMR (D.sub.6 -Acetone, 90 MHz) .delta.9.4 (bs, 1H), 8.1 (d, 1H), 7.9 (d, 1H), 7.6 (dd, 1H), 7.3 (t, 1H), 5.9 (s, 1H), 4.4 (q, 2H), 4.0 (s, 6H), 1.4 (t, 3H).
Using the procedures and examples shown above, the compounds in Tables I and Ia can be prepared.
TABLE I__________________________________________________________________________ ##STR30##R.sub.1 R.sub.2 R X Y Z m.p. (.degree.C.)__________________________________________________________________________CH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CH 192-194 (d)CH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CH 185-187CH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CH 192-195CH.sub.3 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CH 181-183CH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CH 176-177CH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 N 118-120CH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 N 162-164CH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 N 181-183CH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 N 164-165CH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 N 172-174CH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH.sub.3 N 117-120CH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 N 130-131CH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CH 147-148CH.sub.3 OC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 N 179-180CH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub. 3 CHCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CHF.sub.3 CHCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 Cl OCH.sub.3 CHCH.sub. 3 OC.sub.2 H.sub.5 H Cl N(CH.sub.3).sub.2 CHCH.sub.3 OC.sub.2 H.sub.5 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H Br OCH.sub.3 CHC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub. 5 OC.sub.2 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(d)CH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 176-179 (d)CH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 CH.sub. 3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H Br OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 NHCH.sub.3 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N(CH.sub.3).sub.2 CHCH.sub.3 O(CH.sub.2).sub.2 CH.sub.3 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 CH 154-159 (d)C.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 173-176 (d)C.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H Cl OCH.sub.3 CH 140-142 (d)C.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 N 131-135 (d)C.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 145-150 (d)C.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H Br OCH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 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N(CH.sub.3).sub. 2 CHCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 H Br OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 O(CH.sub.2).sub.4 CH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.4 CH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 O(CH.sub.2).sub.4 CH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 O(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H Br OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 O(CH.sub.2).sub. 5 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 O(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.5 CH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 O(CH.sub.2).sub.5 CH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 O(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2)CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 NCH.sub.3 OCH(CH.sub.3)(C.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH(CH.sub.3)(C.sub.2 H.sub.5) H CH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.2 CH(CH.sub.3)(C.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 201-202CH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CH 193-196 (d)CH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CH 198-200 (d)CH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CH 193-195 (d)CH.sub.3 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CH 205-208 (d)CH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 N 185-187 (d)CH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 N 201-204 (d)CH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 SC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 SC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub. 3 SC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 SC.sub.2 H.sub.5 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 SC.sub.2 H.sub.5 H Cl N(CH.sub.3).sub.2 CHCH.sub.3 SC.sub.2 H.sub.5 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CH 158-160 (d)C.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CH 105-107 (d)C.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CH 198-200 (d)C.sub.2 H.sub.5 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CH 97-103 (d)C.sub.2 H.sub.5 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 N 170-172 (d)C.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 N 155-157 (d)C.sub.2 H.sub.5 SC.sub.2 H.sub.5 H Br OCH.sub.3 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 SC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH 122-125 (d)CH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 CH 128-130 (d)CH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 101-104 (d)CH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H Cl OCH.sub.3 CH 137-139 (d)CH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 N 138-140 (d)CH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 111-114 (d)CH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H Br OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub. 3 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H Cl N(CH.sub.3 ).sub.2 CHCH.sub.3 S(CH.sub.2).sub.2 CH.sub.3 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH 142-143 (d)C.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 CH 109-114 (d)C.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 130-133 (d)C.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H Cl OCH.sub.3 CH 98-100 (d)C.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 N 100-103 (d)C.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 108-110 (d)C.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H Br OCH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 S(CH.sub.2).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 S(CH.sub.2).sub.2 CH.sub. 3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.2 CH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 S(CH.sub.2).sub.2 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 SCH(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH 147-149 (d)CH.sub.3 SCH(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CH 107-109 (d)CH.sub.3 SCH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH 114-117 (d)CH.sub.3 SCH(CH.sub.3).sub.2 H Cl OCH.sub.3 CH 144-145 (d)CH.sub.3 SCH(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 N 124-126 (d)CH.sub.3 SCH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N 134-136 (d)C.sub.2 H.sub.5 SCH(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CH 162-163 (d)C.sub.2 H.sub.5 SCH(CH.sub.3 ).sub.2 H OCH.sub.3 OCH.sub.3 CH 87-90 (d)C.sub.2 H.sub.5 SCH(CH.sub.3).sub.2 H OCH.sub.3 Cl CH 152-154 (d)C.sub.2 H.sub.5 SCH(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SCH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N 110-113 (d)CH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H Br OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.3 CH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.3 CH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.3 CH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 S(CH.sub.2).sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SC(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 N 160-162 (d)CH.sub.3 SC(CH.sub.3).sub.3 H OCH.sub.3 CH.sub.3 N 158-159 (d)CH.sub.3 SC(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH 157-158 (d)CH.sub.3 SC(CH.sub.3).sub.3 H OCH.sub.3 CH.sub.3 CH 113-115CH.sub.3 SC(CH.sub.3).sub.3 H Cl OCH.sub.3 CH 105-107 (d)CH.sub.3 SC(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CH 170- 173 (d)C.sub.2 H.sub.5 SC(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 SC(CH.sub.3).sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SC(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 SC(CH.sub.3).sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 SC(CH.sub.3).sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 SC(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H Br OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.4 CH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub. 5 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.4 CH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.4 CH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 S(CH.sub.2).sub.4 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 CH.sub.3 CH 160-167CH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 CH 190-195 (d)CH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 185-191 (d)CH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H Cl OCH.sub.3 CH 108-113 (d)CH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 N 89-95 (d)CH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 90-95 (d)CH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H Br OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.5 CH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.5 CH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(CH.sub.2).sub.5 CH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3 ).sub.2 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 S(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.3 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 NCH.sub.3 SCH(CH.sub.3)(C.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CH(CH.sub.3)(C.sub.2 H.sub.5) H CH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CH(CH.sub.3)(C.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.7 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.7 CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH(CH.sub.3)(n-C.sub.6 H.sub.13) H OCH.sub.3 CH.sub.3 CHCH.sub.3 scyclohexyl H CH.sub.3 CH.sub.3 CHCH.sub.3 scyclohexyl H CH.sub.3 OCH.sub.3 CHCH.sub.3 scyclohexyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 scyclohexyl H Cl OCH.sub.3 CHCH.sub.3 scyclohexyl H CH.sub.3 CH.sub.3 NCH.sub.3 scyclohexyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 SC.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CHCH.sub.3 SC.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SC.sub.6 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 SC.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 NCH.sub.3 SC.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CH 187-189CH.sub.3 SCH.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH 186- 188CH.sub.3 SCH.sub.2 C.sub.6 H.sub.5 H Cl OCH.sub.3 CH 183-185CH.sub.3 SCH.sub.2 C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 N 157-159CH.sub.3 SCH.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 N 145-147CH.sub.3 SCH.sub.2 C.sub.6 H.sub.5 H CH.sub.3 CH.sub.3 CH 196-198CH.sub.3 S(O)(CH.sub.3) H CH.sub.3 CH.sub.3 CH 119-120 (d)CH.sub.3 S(O)(CH.sub. 3) H OCH.sub.3 CH.sub.3 CH 160-161 (d)CH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 CH 190-191 (d)CH.sub.3 S(O)(CH.sub.3) H Cl OCH.sub.3 CH 206-209 (d)CH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 N 198-200 (d)CH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 N 194-196 (d)CH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.3) CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.3) H Br OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 NHCH.sub.3 NCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 S(O)(CH.sub.3) CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.3) H Cl N(CH.sub.3).sub.2 CHCH.sub.3 S(O)(CH.sub.3) H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H Br OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub. 2 CHF.sub.2 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.3) CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.3) H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CH 115-119 (d)CH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CH 105-106 (d)CH.sub.3 S(O)(CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CH 150-155 (d)CH.sub.3 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H Br OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.2 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)((CH(CH.sub.3).sub.2) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH(CH.sub.3).sub.2) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH(CH.sub.3).sub.2) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH(CH.sub.3).sub.2) H Cl OCH.sub.3 CHCH.sub.3 S(O)(CH(CH.sub.3).sub. 2) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH(CH.sub.3).sub.2) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH(CH.sub.3).sub.2) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.3 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.3 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.3 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.3 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.3 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.4 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.4 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.4 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.4 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.4 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.5 CH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)((CH.sub. 2).sub.6 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.7 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.2 CH(CH.sub.3).sub.2) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.5 CH(CH.sub.3).sub.2) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)((CH.sub.2 CH(CH.sub.3)(CH.sub.2 CH.sub.3)) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.3) CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H Br OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.3) H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(O).sub.2 (CH.sub.3) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(O).sub.2 (CH.sub.3) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH(CH.sub.3).sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O).sub.2 (CH.sub.3) H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 (CH(CH.sub.3).sub.2) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH(CH.sub.3).sub.2) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH(CH.sub.3).sub.2) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH(CH.sub.3).sub.2) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH(CH.sub.3).sub.2) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.3 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.3 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.3 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.3 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.3 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.4 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.5 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.6 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.7 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CH(CH.sub.3).sub.2) H CH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 CH.sub.3 CH 167-169 (d)CH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH 190-192 (d)CH.sub.3 OCH.sub.2 CHCH.sub.2 H Cl OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH CH.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 CH.sub.3 N 133-135 (d)CH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 N 174-177CH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CHCH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H Br OCH.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub. 2 CH.sub.2 F CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 OCH.sub.2 CHCH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 OCH.sub.2 CHCH.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H Cl N(CH.sub.3).sub.2 CHCH.sub.3 OCH.sub.2 CHCH.sub.2 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CHCH.sub.2 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CHCH.sub.2 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CHCH.sub.2 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 NC.sub. 2 H.sub.5 OCH.sub.2 CHCH.sub.2 H Br OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 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CHCHCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CHCHCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CHCHCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 SCH.sub.2 CHCHCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CHCHCH.sub.3 H OCH.sub.3 POCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CHCHCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CHCHCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 SCH.sub.2 CHCHCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CHCHC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CHCHC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 SCH.sub.2 CHCHC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 SCH.sub.2 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CHC.sub.2 H.sub.5 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CHCHC.sub.2 H.sub.5 H ICH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CHCHC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 SCH.sub.2 CHCHC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub. 3 NCH.sub.3 S(CH.sub.2).sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H Cl OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H Br OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.2 CHCH.sub.2) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CHCH.sub.2) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 N(CH.sub.3).sub.2 NCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CHCH.sub.2) H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCHCH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCHCH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCHCH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCHCH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHCHCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2).sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCHCH.sub.2 CH.sub.3) H OCH.sub.3 POCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CHCH(CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.2 CHCHCH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CHC(CH.sub.3).sub.2) H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CCH H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH H Cl OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 SCH.sub.2 CCH H CH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 C CH H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 SCH.sub.2 CCH CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CCH CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CCH CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH H Br OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH CH.sub.3 OCH.sub.3 N(CH.sub.3).sub. 2 NCH.sub.3 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 NHCH.sub.3 NCH.sub.3 SCH.sub.2 CCH H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 SCH.sub.2 CCH H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 SCH.sub. 2 CCH H OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 SCH.sub.2 CCH CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH H Cl N(CH.sub.3).sub.2 CHCH.sub.3 SCH.sub.2 CCH H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H Cl OCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 C CH H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCH H Br OCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 SCH.sub.2 CCH H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CF.sub.2 CHC.sub.2 H.sub.5 SCH.sub.2 C CH H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 SCH.sub.2 CCH H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 SCH.sub.2 CCH CH.sub.3 OCH.sub.3 PCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCH CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCH CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 SCH.sub.2 C CH H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 SCH.sub.2 CCH H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCH H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCH H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 SCH.sub.2 CCH H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 SCH.sub.2 CCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 (N(CH.sub.3).sub.2 NCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 SCH.sub.2 CCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 SCH.sub.2 CCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 SCH.sub.2 CCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 SCH.sub.2 C CCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 SCH.sub.2 C CC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 SCH.sub.2 CCC.sub. 2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCC.sub.2 H.sub.5 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 (N(CH.sub.3).sub.2 CHCH(CH.sub.3 us,5 2 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 SCH.sub.2 CCC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(CH.sub.2).sub.2 CCH H CH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CCH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.2 CCH H CH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CCH) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) H Cl OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O)(CH.sub.2 C CH) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CCH) CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CCH) CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) H Br OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 S(O)(CH.sub.2 CCH) H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCH) H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.2 CCH) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CCH) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CCH) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CCH) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 S(O)(CH.sub.2 CCH) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 S(O)(CH.sub.2 CCH) H OCH.sub.3 N(CH.sub.3).sub.2 NCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CCH) H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CCH) H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CCH) H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 S(O)(CH.sub.2 CCH) H OCH.sub.3 CH.sub.3 NCH(CH.sub. 3).sub.2 S(O)(CH.sub.2 CCH) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.2 CCCH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.2 CCCH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.2 CCCH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CH.sub.2 CCCH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)(CH.sub.2 CH.sub.2 CCCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)((CH.sub.2).sub.2 CCH) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2 CCCH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.2 CCCH.sub. 2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)((CH.sub.2).sub.4 CCH) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CHCH.sub.2) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHCH.sub.2) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHCH.sub.2) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CHCH.sub.2) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CHCHCH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHCHCH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHCHCH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHCHCH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CHCHCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CHCH.sub.2) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHCHCH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CHCH(CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CHCH(CH.sub.2).sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CHC(CH.sub.3).sub.2) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CCH) H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CCH) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CCH) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CCH) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CCH) H CH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CCH) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CCH) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CCCH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CCCH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CCCH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2 CCCH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2 CCCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 C CH) H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CCCH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CCCH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.2 CCCH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 ((CH.sub.2).sub.4 CCH) H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 NCH.sub. 3 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub. 3 CH.sub.2 CH.sub.2 F H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 NHCH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 F CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 F H Cl N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 CH.sub.2 F H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H Br OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub. 2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 F CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub. 3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 OC.sub. 2 H.sub.5 NCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CHF.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 CHF.sub.2 H Cl N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H Br OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CHF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 CH.sub.2 CHF.sub.2 H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CHF.sub.2 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CF.sub. 3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CF.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CF.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CF.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 CF.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 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OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CHF.sub.2 H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 CHF.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 CHF.sub.2 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 CHF.sub.2 H Cl N(CH.sub.3).sub.2 CHCH.sub.3 CHF.sub.2 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CHF.sub.2 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CHF.sub.2 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CHF.sub.2 H Br OCH.sub.3 CHC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CHF.sub.2 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 CHF.sub.2 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub. 2 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CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CHF.sub.2 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CHF.sub.2 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CH 147-148 (d)CH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 151-153 (d)CH.sub.3 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 N 110-112 (d)CH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 N 105-106 (d)CH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.3 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.3 H Cl N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 OCH.sub.3 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H Br OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub. 2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub. 2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub. 3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub. 5 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H Cl N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H Br OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub. 3 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 Cl CHCH.sub.3 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 Cl CHC.sub.2 H.sub.5 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H CH.sub.3 CH.sub. 3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub. 3 H Br OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.3 OCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 OCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub. 2 (CH.sub.2).sub.3 OCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 CH.sub.3 OCH.sub. 3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.4 OCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.4 OCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 OCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub. 3 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 n(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3 ).sub.2 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H CL OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 OC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 OC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH(CH.sub.3)(OCH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 CH(CH.sub.3)(OCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH(CH.sub.3)(OC.sub.2 H.sub.5) H CH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 CH(CH.sub.3)(OC.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH(C.sub.2 H.sub.5)(OCH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 CH(C.sub.2 H.sub.5)(OC.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH(C.sub.2 H.sub.5)(OCH.sub.3) H CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH(C.sub.2 H.sub.5)(OC.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 CHCH.sub. 3 CH(CH.sub.3)(CH.sub.2 OCH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH(CH.sub.3)(CH.sub.2 OCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CH 163-165CH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CH 152-154CH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 146-148CH.sub.3 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CH 140-142CH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 N 131-135CH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 N 123-125CH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 CH.sub.2 SCH.sub.3 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.3 H Cl N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 SCH.sub.3 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub. 3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H Br OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 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CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 SCH.sub.3 H 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CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H Br OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 CH.sub.2 SCH.sub.3 H 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OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCHphd 3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 SCH.sub. 3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH(CH.sub.3)(SCH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH(CH.sub.3)(SCH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH(CH.sub.3)(SCH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 CH(CH.sub.3)(SCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH(CH.sub.3)(SCH.sub.3) H OCH.sub.3 Cl CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub. 2 NCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.3 SCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 SCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H CH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub. 4 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.4 SCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.4 SCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 SCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.4 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHCH.sub. 3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub. 3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H Br OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCHp.sub.2 CF.sub.3 CHCH.sub.3 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub. 2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.3 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SC.sub.2 H.sub.5 H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 SC.sub.2 H.sub.5 H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.4 SC.sub.2 H.sub.5 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH(CH.sub.3)(SCH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 CH(CH.sub.3)(SCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH(CH.sub.3)(SC.sub.2 H.sub.5) H CH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 CH(CH.sub.3)(SC.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH(C.sub.2 H.sub.5)(SCH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 CH(C.sub.2 H.sub.5)(SC.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH(C.sub.2 H.sub.5)(SCH.sub.3) H CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CH(C.sub.2 H.sub.5)(SC.sub.2 H.sub.5) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH(CH.sub.3)(CH.sub.2 SCH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 CH(CH.sub.3)(CH.sub.2 SCH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 NHCH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 CH.sub. 2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 CH.sub.2 S(O)(CH.sub.3) CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H Cl N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.3) H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H Br OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H OCH.sub. 3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.3) H OCH.sub.3 NHCH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3 ) CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub. 3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 S(O)(CH.sub.3) H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 (CH.sub.2).sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 (CH.sub.2).sub.2 S(O)(CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 (CH.sub.2).sub.2 S(O)(CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 (CH.sub.2).sub.2 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 S(O)(CH.sub. 2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O)(CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 S(O)(CH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 S(O)(CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 S(O)(CH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 S(O)(CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH(CH.sub.3)(S(O)(CH.sub.3)) H CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub. 3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H Br OCH.sub. 3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.34 NHCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H Cl N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.3) H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H Br OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 CH.sub.2 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.3 NCH(CH.sub.3 ).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.3) H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub. 3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H Br OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.2 CF.sub. 3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 POCH.sub.2 CF.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 N(CH.sub.3).sub.2 NCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub. 2 CH.sub.3) H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 CH.sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H Cl OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 (CH.sub.2).sub.2 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 (CH.sub.2).sub.3 S(O).sub.2 (CH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 (CH.sub.2).sub.4 S(O).sub.2 (CH.sub.3) H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2).sub.3 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2).sub.4 S(O).sub.2 (CH.sub.2 CH.sub.3) H OCH.sub.3 CH.sub.3 NCH.sub.3 CH(CH.sub.3)(S(O).sub.2 (CH.sub.3)) H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 OCF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCF.sub.2 H H Cl OCH.sub.3 CHCH.sub.3 OCF.sub.2 H H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 OCF.sub.2 H H CH.sub.3 CH.sub.3 NCH.sub.3 OCF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 OCF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCF.sub.2 H H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCF.sub.2 H H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCF.sub.2 H CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 OCF.sub.2 H CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 OCF.sub.2 H CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 OCF.sub.2 H CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCF.sub.2 H H Br OCH.sub.3 CHCH.sub.3 OCF.sub.2 H CH.sub.3 OCH.sub.3 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OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 175-177 (d)CH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CH 98-100 (d)CH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 N 117-120 (d)CH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 N 75-80 (d)CH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 N 154-156 (d)CH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCH.sub.2 CH.sub. 2 OCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub. 3 H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H Cl N(CH.sub.3).sub.2 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H Cl OC.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3 H Cl 0C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H Br OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 C.sub.2 H.sub. 5 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub. 3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub. 3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H Br OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub. 3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H Cl N(CH.sub.3).sub.2 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.3 H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 OCH.sub. 2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H Br OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub. 2 CF.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 OCH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.3 OCH.sub.3 OCH.sub.3 N -n-C.sub.3 H.sub.7 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH -n-C.sub.3 H.sub.7 OCH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 OCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCH.sub.2 CH.sub.3 H OCH.sub.2 CH.sub.3 NHCH.sub.3 NCH.sub.3 CH.sub.2 CH.sub.3 H OCH.sub.2 CH.sub.3 NHCH.sub.3 NCH.sub.3 SC(CH.sub.3).sub.3 H OCH.sub.2 CH.sub.3 NHCH.sub.3 NCH.sub.3 S(O)CH.sub.2 CH.sub.3 H OCH.sub.2 CH.sub.3 NHCH.sub.3 NCH.sub.3 S(O)CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.2 CH.sub.3 NHCH.sub.3 N__________________________________________________________________________
TABLE Ia__________________________________________________________________________ ##STR31##R.sub.1 R.sub.2 R X Y Z m.p. (.degree.C.)__________________________________________________________________________CH.sub.3 Ocyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 Ocyclopropyl H Cl OCH.sub.3 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 N(CH.sub.3).sub.2 CHCH.sub.3 Ocyclopropyl H CH.sub.3 CH.sub.3 NCH.sub.3 Ocyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 Ocyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 Ocyclopropyl H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 Ocyclopropyl CH.sub.3 OCH.sub.3 CH.sub.3 NCH.sub.3 Ocyclopropyl CH.sub.3 OCH.sub.3 OCH.sub.3 NCH.sub.3 Ocyclopropyl CH.sub.3 CH.sub.3 OCH.sub.3 NCH.sub.3 Ocyclopropyl CH.sub.3 OCH.sub.3 OCH.sub.3 CHCH.sub.3 Ocyclopropyl H Br OCH.sub.3 CHCH.sub.3 Ocyclopropyl CH.sub.3 OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 Ocyclopropyl H CH.sub.3 OCH.sub.2 CF.sub.3 NCH.sub.3 Ocyclopropyl H CH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CF.sub.3 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 C.sub.2 H.sub.5 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 C.sub.2 H.sub.5 NCH.sub.3 Ocyclopropyl H OCH.sub.3 NHCH.sub.3 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 NHCH.sub.3 NCH.sub.3 Ocyclopropyl H CH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 OC.sub.2 H.sub.5 CHCH.sub.3 Ocyclopropyl H CH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 Ocyclopropyl H OCH.sub.3 OC.sub.2 H.sub.5 NCH.sub.3 Ocyclopropyl H CH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHCH.sub.3 Ocyclopropyl H CH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CHF.sub.2 NCH.sub.3 Ocyclopropyl H CH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHCH.sub.3 Ocyclopropyl H CH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 Ocyclopropyl CH.sub.3 OCH.sub.3 OCH.sub.2 CH.sub.2 F NCH.sub.3 Ocyclopropyl CH.sub.3 Cl OCH.sub.3 CHCH.sub.3 Ocyclopropyl H Cl N(CH.sub.3).sub.2 CHCH.sub.3 Ocyclopropyl H Cl OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 Ocyclopropyl H CH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 CH.sub.3 CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 Ocyclopropyl H Cl OCH.sub.3 CHC.sub.2 H.sub.5 Ocyclopropyl H CH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 CH.sub.3 NC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OCH.sub. 3 NC.sub.2 H.sub.5 Ocyclopropyl H Br OCH.sub.3 CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 N(CH.sub.3).sub.2 CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 N(CH.sub.3).sub.2 NC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 NHCH.sub.3 NC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 C.sub.2 H.sub.5 CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 C.sub.2 H.sub.5 NC.sub.2 H.sub.5 Ocyclopropyl H CH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 Ocyclopropyl H CH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OC.sub.2 H.sub.5 CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OC.sub.2 H.sub.5 NC.sub.2 H.sub.5 Ocyclopropyl H CH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 Ocyclopropyl H CH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CF.sub.3 CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CF.sub.3 NC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CHF.sub.2 CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 Ocyclopropyl H CH.sub.3 OCH.sub.2 CHF.sub.2 NC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CH.sub.2 F CHC.sub.2 H.sub.5 Ocyclopropyl H OCH.sub.3 OCH.sub.2 CH.sub.2 F NC.sub.2 H.sub.5 Ocyclopropyl CH.sub.3 OCH.sub.3 OCH.sub.3 CHC.sub.2 H.sub.5 Ocyclopropyl CH.sub.3 CH.sub.3 OCH.sub.3 NC.sub.2 H.sub.5 Ocyclopropyl CH.sub.3 OCH.sub.3 OCH.sub.3 Nn-C.sub.3 H.sub.7 Ocyclopropyl H OCH.sub.3 OCH.sub.3 CHn-C.sub.3 H.sub.7 Ocyclopropyl H CH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 Ocyclopropyl H OCH.sub.3 CH.sub.3 CHCH(CH.sub.3).sub.2 Ocyclopropyl H OCH.sub.3 OCH.sub.3 CHCH(CH.sub.3).sub.2 Ocyclopropyl H Cl OCH.sub.3 CHCH(CH.sub.3).sub.2 Ocyclopropyl H OCH.sub.3 CH.sub.3 NCH(CH.sub.3).sub.2 Ocyclopropyl H OCH.sub.3 OCH.sub.3 NCH(CH.sub.3).sub.2 Ocyclopropyl H OCH.sub.3 N(CH.sub.3).sub.2 NCH.sub.3 OCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 Ocyclobutyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 Ocyclobutyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 Ocyclobutyl H OCH.sub.3 Cl CHCH.sub.3 Ocyclobutyl H CH.sub.3 CH.sub.3 CHCH.sub.3 Ocyclobutyl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 Ocyclobutyl H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH(CF.sub.3)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 Cl CHCH.sub.3 OCH(CH.sub.2 F).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH(CH.sub.2 F)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 O(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 O(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 O(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 OC(Cl)CHCl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OC(Cl)CHCl H OCH.sub.3 CH.sub.3 CHCH.sub.3 OC(Cl)CHCl H OCH.sub.3 Cl CHCH.sub.3 OC(Cl)CHCl H CH.sub.3 CH.sub.3 CHCH.sub.3 OC(Cl)CHCl H OCH.sub.3 OCH.sub.3 NCH.sub.3 OC(Cl)CHCl H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CCCH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 SCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 OCH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 C(O)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub. 2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 OCF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 OCF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 OCF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 OCH.sub.2 CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 OCH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 Scyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 Scyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 Scyclopropyl H OCH.sub.3 Cl CHCH.sub.3 Scyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 Scyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 Scyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 Scyclobutyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 Scyclobutyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 Scyclobutyl H OCH.sub.3 Cl CHCH.sub.3 Scyclobutyl H CH.sub.3 CH.sub.3 CHCH.sub.3 Scyclobutyl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 Scyclobutyl H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 SCH(CF.sub.3)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 Cl CHCH.sub.3 SCH(CH.sub.2 F).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH(CH.sub.3 F).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 SCH(CH.sub.2 F)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 OCH.sub. 3 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 SC(Cl)CHCl H OCH.sub.3 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SCH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 OCH.sub.2 CF.sub. 3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 SCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 SCH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CN H OCH.sub.3 Cl 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CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 SCH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CHF.sub.2 H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 SCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 SCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 SCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 SCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 S(O)cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)cyclobutyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)cyclobutyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)cyclobutyl H OCH.sub.3 Cl CHCH.sub.3 S(O)cyclobutyl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)cyclobutyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)cyclobutyl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CF.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH(CF.sub.3)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH(CF.sub.3)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CF.sub.2 CF.sub.2 H H 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CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 S(O)(CH.sub.2).sub.5 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O)(CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)C(Cl)CHCl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)C(Cl)CHCl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)C(Cl)CHCl H OCH.sub.3 Cl CHCH.sub.3 S(O)C(Cl)CHCl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)C(Cl)CHCl H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)C(Cl)CHCl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CCCH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 C(O)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 OCH.sub. 2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 S(O)CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O)CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub. 3 S(O)CH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O)CH.sub.2 CF.sub. 3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2cyclobutyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2cyclobutyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub. 2cyclobutyl H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2cyclobutyl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2cyclobutyl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O).sub.2cyclobutyl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH(CH.sub.2 F).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 (CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 (CH.sub.2).sub.5 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 (CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O).sub.2 (CH.sub.2).sub.5 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 C(Cl)CHCl H OCH.sub.3 OCH.sub. 3 CHCH.sub.3 S(O).sub.2 C(Cl)CHCl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 C(Cl)CHCl H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 C(Cl)CHCl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 C(Cl)CHCl H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 C(Cl)CHCl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 C(O)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub. 3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub. 3 S(O).sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O).sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 S(O).sub.2 CH.sub.2 CF.sub. 3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH(CF.sub.3)CH.sub. 3 H OCH.sub.3 Cl CHCH.sub.3 NHCH(CF.sub.3)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NHCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH(CH.sub.2 F).sub.2 H OCH.sub.3 Cl CHCH.sub.3 NHCH(CH.sub.2 F).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH(CH.sub.2 F).sub.2 H OCH.sub. 3 CH.sub.3 NCH.sub.3 NHCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH(CH.sub.2 F)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NH(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NH(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 NH(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 NH(CH.sub.2).sub.3 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 NH(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NH(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 NHC(Cl)CHCl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHC(Cl)CHCl H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHC(Cl)CHCl H OCH.sub.3 Cl CHCH.sub.3 NHC(Cl)CHCl H CH.sub.3 CH.sub.3 CHCH.sub.3 NHC(Cl)CHCl H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHC(Cl)CHCl H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CCCH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NHCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 SCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NHCH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 CH.sub. 3 CHCH.sub.3 NHCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 C(O)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub. 3 NHCH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CHF.sub.2 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NHCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 OH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 OH H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 OH H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 OH H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 OH H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub. 2 OH H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 NH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 NH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 NH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 NH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 NH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 NH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NHCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 SCH.sub. 3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 S(O)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 NHCH.sub.2 CH.sub.2 S(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 NHCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 NHCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2 S(O).sub.2 CH.sub.3 H OCH.sub. 3 CH.sub.3 NCH.sub.3 CH.sub.2 Ocyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 Ocyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 Ocyclopropyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 Ocyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 Ocyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 Ocyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 Ocyclobutyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 Ocyclobutyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 Ocyclobutyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 Ocyclobutyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 Ocyclobutyl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub. 2 Ocyclobutyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH(CF.sub.3)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH(CH.sub.2 F).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH(CH.sub.2 F)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 O(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 O(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 O(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 O(CH.sub.2).sub.3 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 O(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 O(CH.sub.3).sub.3 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub. 3 NCH.sub.3 CH.sub.2 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 CCCH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 SCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 SCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH 92-95CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CH 115-117CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 N 150-152CH.sub.3 CH.sub. 2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 N 100-103CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH 81-83CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CH 100-101CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 N 125-127CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 N 142-144CH.sub.3 CH.sub.2 OCH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CHF.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CH 118-120CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CH 139-141CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CH 124-125CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CH 159-161CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 N 128-130CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 N 106-109CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub. 3 CH 85-89CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CH 110-113CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CH 106-110CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CH 134-136CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 N >250CH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 CF.sub. 3 H OCH.sub.3 CH.sub.3 N 126-128CH.sub.3 CH.sub.2 OCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CCH H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CCH H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 CCH H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CCH H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 100-103CH.sub.3 CH.sub.2 OC(O)CH.sub.3 H OCH.sub.3 CH.sub.3 CH 165-167CH.sub.3 CH.sub.2 OC(O)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OC(O)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OC(O)CH.sub.3 H OCH.sub.3 CH.sub.3 N 127-130CH.sub.3 CH.sub.2 OC(O)CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OC(O)CH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 OC(O)CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OC(O)OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OC(O)OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OC(O)OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OH H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OH H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OH H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OH H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OH H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OP(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OP(O)(OCH.sub.2).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OP(O)(OCH.sub.2).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OP(O)(OCH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OP(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 OP(O)(OCH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OSO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OSO.sub. CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OSO.sub.2 CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OSO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OSO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OSO.sub.2 CH.sub.3 H OCH.sub.2 CH.sub.3 NCH.sub.3 CH.sub.2 OC(O)NHCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)NHCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)NHCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OC(O)NHCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)NHCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OC(O)NHCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OC(O)N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OC(O)N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OC(O)N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 OC(O)N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OSi(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OSi(CH.sub.3).sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OSi(CH.sub.3).sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OSi(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OSi(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OSi(CH.sub.3).sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 168-170CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CH 90-91CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CH 109-111CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CH 120-122CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 N 135-137CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.3 OCH.sub.3 H OCH.sub.3 CH.sub.3 N 139-141CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 168-170CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CH 91-92CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CH 109-111CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CH 120-122CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 N 135-137CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 N 139-141CH.sub. 3 CH.sub.2 OCH.sub.2 C(H)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(H)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(H)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 C(H)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(H)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 C(H)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 Scyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 Scyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 Scyclopropyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 Scyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 Scyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 Scyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 Scyclobutyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 Scyclobutyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 Scyclobutyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 Scyclobutyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 Scyclobutyl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 Scyclobutyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub. 3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH(CF.sub.3)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH(CH.sub.2 F).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH(CH.sub.2 F)CH.sub. 3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(CH.sub.2).sub.3 CH.sub.3 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(CH.sub.2).sub.3 CH.sub.3 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 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CHCH.sub.3 CH.sub.2 SCH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CHF.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CCH H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CCH H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CCH H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CCH H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CCH H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SH H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SH H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SH H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SH H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 SH H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SP(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SP(O)(OCH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SP(O)(OCH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SP(O)(OCH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SP(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 SP(O)(OCH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 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CHCH.sub.3 CH.sub.2 S(O)cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)cyclobutyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)cyclobutyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)cyclobutyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)cyclobutyl H CH.sub.3 CH.sub.3 CHCH.sub. 3 CH.sub.2 S(O)cyclobutyl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O)cyclobutyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 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C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 CH.sub. 2 S(O)CH.sub.2 CCCH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O)CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CHF.sub.2 H OCH.sub. 3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O)CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCH H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCH H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCH H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CCH H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(H)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O)CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2cyclopropyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2cyclopropyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub. 2 S(O).sub.2cyclobutyl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2cyclobutyl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2cyclobutyl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2cyclobutyl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2cyclobutyl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O).sub.2cyclobutyl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub. 3 CH.sub.2 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH(CF.sub.3)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.2 CF.sub.2 H H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub. 2 F).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub. 3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH(CH.sub.2 F)CH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2).sub.3 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O).sub.2 (CH.sub.2).sub.3 CH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub. 3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O)CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCH H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCH H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCH H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CCH H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub. 2 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CN H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CN H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CHF.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub. 2 C(H)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(H)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(H)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.2 CH.sub.3 CH.sub.2 S(O).sub.2 CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 C(H)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 C(H)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 C(H)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 C(H)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 C(H)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 C(H)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CCH H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CCH H OCH.sub.3 CH.sub.3 CHCH.sub.3 CCH H OCH.sub.3 Cl CHCH.sub.3 CCH H CH.sub.3 CH.sub.3 CHCH.sub.3 CCH H OCH.sub.3 OCH.sub.3 NCH.sub.3 CCH H OCH.sub.3 CH.sub.3 NCH.sub.3 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 C(Cl)CH.sub.2 H OCH.sub.3 Cl CHCH.sub.3 C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 C(Cl)CH.sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 C(O)NHCH.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 C(O)NHCH.sub.3 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 C(O)NHCH.sub.3 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 C(O)NHCH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 C(O)NHCH.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub. 3 CH.sub.2 C(O)NHCH.sub.3 H OCH.sub.3 CH.sub.3 NCH.sub.3 CH.sub.2 C(O)N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 C(O)N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 C(O)N(CH.sub.3).sub.2 H OCH.sub.3 Cl CHCH.sub.3 CH.sub.2 C(O)N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CHCH.sub.3 CH.sub.2 C(O)N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 C(O)N(CH.sub.3).sub.2 H OCH.sub.3 CH.sub.3 NCH.sub.3 OCF.sub.3 H CH.sub.3 OCH.sub.3 CHCH.sub.3 OCF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OCF.sub.3 H Cl OCH.sub.3 CHCH.sub.3 OCF.sub.3 H CH.sub.3 OCH.sub.3 NCH.sub.3 OCF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 SCF.sub.3 H CH.sub.3 OCH.sub.3 CHCH.sub.3 SCF.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 SCF.sub.3 H Cl OCH.sub.3 CHCH.sub.3 SCF.sub.3 H CH.sub.3 OCH.sub.3 NCH.sub.3 SCF.sub.3 H OCH.sub.3 OCH.sub.3 NCH.sub.3 OCH.sub.2 CH.sub.2 Br H CH.sub.3 OCH.sub.3 CHCH.sub.3 OCH.sub.2 CH.sub.2 I H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CCI H CH.sub.3 OCH.sub.3 NCH.sub.3 CH.sub.2 CBr.sub.3 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 N(CH.sub.3)(CH.sub.2 CH.sub.3) H CH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CH 176-180(d)CH.sub.3 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 CH 167-170CH.sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH 149-153(d)CH.sub.3 CH.sub.2 Cl H Cl OCH.sub.3 CH 164-166CH.sub.3 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 N 148-150CH.sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 N 161-162CH.sub.2 CH.sub.3 CH.sub.2 Cl H CH.sub.3 CH.sub.3 CH 158-162CH.sub.2 CH.sub.3 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 CHCH.sub.2 CH.sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH 141-144CH.sub.2 CH.sub.3 CH.sub.2 Cl H Cl OCH.sub.3 CH 158-162CH.sub.2 CH.sub.3 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 N 134-142CH.sub.3 CH.sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 N GumCH.sub.2 CH.sub.3 CHBr.sub.2 H OCH.sub.3 OCH.sub.3 CH 181-182CH.sub.3 CHBr.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CH.sub.2 Br H OCH.sub.3 OCH.sub.3 CHCH.sub.3 CHCl.sub.2 H OCH.sub.3 OCH.sub.3 CHCH.sub.3 OC(O)CH.sub.3 H CH.sub.3 CH.sub.3 CHCH.sub.3 OC(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CHCH.sub.3 OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 188-190CH.sub.3 OC(O)CH.sub.3 H Cl OCH.sub.3 CHCH.sub.3 OC(O)CH.sub.3 H CH.sub.3 OCH.sub.3 NCH.sub.3 OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 N__________________________________________________________________________
Formulations
Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid inert diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:
TABLE II______________________________________ Active Weight Percent* Ingredient Diluent(s) Surfactant(s)______________________________________Wettable Powders 20-90 0-74 1-l0Oil Suspensions, 3-50 40-95 0-15Emulsions, Solutions,(including EmulsifiableConcentrates)Aqueous Suspension 10-50 40-84 1-20Dusts l-25 70-99 0-5Granules and Pellets 0.1-95 5-99.9 0-15High Strength 90-99 0-10 0-2Compositions______________________________________ *Active ingredient plus at least one of a Surfactant or a Diluent equals 100 weight percent.
Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.
Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, N.J., but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0.degree. C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.
The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff.
For further information regarding the art of formulation, see for example:
H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;
R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;
H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;
G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pp. 81-96; and
J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.
In the following examples, all parts are by weight unless otherwise indicated.
EXAMPLE 16
Wettable Powder
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 80%sodium alkylnaphthalenesulfonate 2%sodium ligninsulfonate 2%synthetic amorphous silica 3%kaolinite 13%______________________________________
The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged.
EXAMPLE 17
Wettable Powder
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 50%sodium alkylnaphthalenesulfonate 2%low viscosity methyl cellulose 2%diatomaceous earth 46%______________________________________
The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.
EXAMPLE 18
Granule
______________________________________Wettable Powder of Example 17 5%attapulgite granules 95%(U.S.S. 20-40 mesh; 0.84-0.42 mm)______________________________________
A slurry of wettable powder containing 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.
EXAMPLE 19
Extruded Pellet
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 25%anhydrous sodium sulfate 10%crude calcium ligninsulfonate 5%sodium alkylnaphthalenesulfonate 1%calcium/magnesium bentonite 59%______________________________________
The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.
EXAMPLE 20
Oil Suspension
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 25%polyoxyethylene sorbitol hexaoleate 5%highly aliphatic hydrocarbon oil 70%______________________________________
The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.
EXAMPLE 21
Wettable Powder
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 20%sodium alkylnaphthalenesulfonate 4%sodium ligninsulfonate 4%low viscosity methyl cellulose 3%attapulgite 69%______________________________________
The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) and packaged.
EXAMPLE 22
Low Strength Granule
______________________________________2-[[(4,6-dimethoxpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 1%N,N--dimethylformamide 9%attapulgite granules 90%(U.S.S. 20-40 sieve)______________________________________
The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged.
EXAMPLE 23
Aqueous Suspension
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 40%polyacrylic acid thickener 0.3%dodecylphenol polyethlene glycol ether 0.5%disodium phoshate 1%monosodium phosphate 0.5%polyvinyl alcohol 1.0%water 56.7%______________________________________
The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size.
EXAMPLE 24
Solution
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 5%water 95%______________________________________
The salt is added directly to the water with stirring to produce the solution, which may then be packaged for use.
EXAMPLE 25
Low Strength Granule
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 0.1%attapulgite granules 99.9%(U.S.S. 20-40 mesh)______________________________________
The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.
EXAMPLE 26
Granule
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acidmethyl ester 80%wetting agent 1%crude ligninsulfonat salt (containing 10%5-20% of the natural sugars)attapulgite clay 9%______________________________________
The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use.
EXAMPLE 27
High Strength Concentrate
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 99%silica aerogel 0.5%synthetic amorphous silica 0.5%______________________________________
The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary.
EXAMPLE 28
Wettable Powder
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 90%dioctyl sodium sulfosuccinate 0.1%synthetic fine silica 9.9%______________________________________
The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged.
EXAMPLE 29
Wettable Powder
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 40%sodium ligninsulfonate 20%montmorillonite clay 40%______________________________________
The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged.
EXAMPLE 30
Oil Suspension
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 35%blend of polyalcohol carboxylic 6%esters and oil soluble petroleumsulfonatesxylene 59%______________________________________
The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.
EXAMPLE 31
Dust
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 10%attapulgite 10%pyrophyllite 80%______________________________________
The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.
EXAMPLE 32
Emulsifiable Concentrate
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(methylthio)benzoic acid,methyl ester 20%chlorobenzene 74%sorbitan monostearate and polyoxyethylenecondensates thereof 6%______________________________________
The ingredients are combined and stirred to produce a solution which can be emulsified in water for application.
EXAMPLE 33
Granule
______________________________________2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-4-(difluoromethoxy)benzoic acid,ethyl ester 80%wetting agent 1%crude ligninsulfonate salt (containing 10%5-20% of the natural sugars)attapulgite clay 9%______________________________________
The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use.
Utility
Test results indicate that the compounds of the present invention are highly active preemergent or postemergent herbicides or plant growth regulants. Many of them have utility for broad-spectrum pre and/or postemergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, ammunition depots, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Some of the compounds have utility for selective weed control in crops such as wheat, barley, cotton, soybean, sugar beets and corn. Alternatively, the subject compounds are useful to modify plant growth.
The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.05 to 10 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required.
The compounds of this invention may be used in combination with other commercial herbicides. They are particularly useful in combination with the following herbicides.
______________________________________Common Name Chemical Name______________________________________acifluorfen 5-[2-chloro-4-(trifluoromethyl)phenoxy]- 2-nitrobenzoic acidacrolein acroleinalachlor 2-chloro-2',6'-diethyl-N--(methoxymethyl)- acetanilideametryn 2-(ethylamino)-4-(isopropylamino)-6- methylthio)- .sub.-s-triazineamitrole 3-amino- .sub.-s-triazoleAMS ammonium sulfamateasulam methyl sulfanilylcarbamateatrazine 2-chloro-4-(ethylamino)-6-(isopropyl- amino)- .sub.-s-triazinebarban 4-chloro-2-butynyl .sub.--m-chlorocarbanilatebenefin N--butyl-N--ethyl-.alpha.,.alpha.,.alpha.-trifluoro-2,6- dinitro- -p-toluidinebensulide O,O--diisopropyl phosphorodithioate S--ester with N--(2-mercaptoethyl)- benzenesulfonamidebentazon 3-isopropyl-lH--2,1,3-benzothiadiazin- 4(3H)--one 2,2-dioxidebenzipram 3,5-dimethyl-N--(1-methylethyl)-N-- (phenylmethyl)benzamidebenzoylprop N--benzoyl-N--(3,4-dichlorophenyl)-DL- alainebifenox methyl 5-(2,4-dichlorophenoxy)-2- nitrobenzoatebromacil 5-bromo-3-sec-butyl-6-methyluracilbromoxynil 3,5-dibromo-4-hydroxybenzonitrilebutachlor N--(butoxymethyl)-2-chloro-2',6'- diethylacetanilidebutam 2,2-dimethyl-N--(1-methylethyl)-N-- (phenylmethyl)propanamidebuthidazole 3-[5-(1,1-dimethylethyl)-1,3,4-thiadia- zol-2-yl]-4-hydroxy-1-methyl-2-imida- zolidinonebutralin 4-(1,1-dimethylethyl)-N--(1-methyl- propyl)-2,6-dinitrobenzenaminebutylate S--ethyl-diisobutylthiocarbamatecacodylic hydroxydimethylarsine oxideacidcarbetamide D-N--ethyllactamide carbanilate (ester)CDAA N--N--diallyl-2-chloroacetamideCDEC 2-chloroallyl diethyldithiocarbamatechlorbromuron 3-(4-bromo-3-chlorophenyl)-1-methoxy-1- methylureachloroxuron 3-[p-(p-chlorophenoxy)phenyl]-1,1- dimethylureachlorpropham isopropyl .sub.--m-chlorocarbanilatechlorsulfuron 2-chloro-N--(4-methoxy-6-methyl-1,3,5- triazin-2-yl)aminocarbonyl] benzene- sulfonamidechlortoluron N'-(3-chloro-4-methylphenyl-N',N'- dimethylureacisanilide cis-2,5-dimethyl-N-- phenyl-1-pyrrolidine- carboxamideCMA calcium methanearsonatecyanazine 2-[[4-chloro-6-(ethylamino)- .sub.-s-triazin-2- yl]amino]-2-methylpropionitrilecycloate S--ethyl N--ethylthiocyclohexanecarbamatecycluron 3-cyclooctyl-1,1-dimethylureacyperquat 1-methyl-4-phenylpyridiniumcyprazine 2-chloro-4-(cyclopropylamino)-6-(iso- propylamino- .sub.-s-triazinecyprazole N--[5-(2-chloro-1,1-dimethylethyl)-1,3,4- thiadiazol-2-yl]cyclopropanecarbox- amidecypromid 3',4'-dichlorocyclopropanecarboxanilidedalapon 2,2-dichloropropionic aciddazomet tetrahydro-3,5-dimethyl-2H--1,3,5-thia- diazine-2-thioneDCPA dimethyl tetrachloroterephthalatedesmetryn 2-(isopropylamino)-4-(methylamino)-6- methylthio)- .sub.-s-triazinediallate S--(2,3-dichloroallyl)diisopropylthio- carbamatedicamba 3,6-dichloro- -o-anisic aciddichlobenil 2,6-dichlorobenzonitriledichlorprop 2-(2,4-dichlorophenoxy)propionic aciddiclofop 2-[4-(2,4-dichlorophenoxy)phenoxy]- propanoic aciddiethatyl N--(chloroacetyl)-N--(2,6-diethylphenyl)- glycinedifenzoquat 1,2-dimethyl-3,5-diphenyl-1H--pyrazoliumdinitramine N.sup.4,N.sup.4 --diethyl-.alpha.,.alpha.,.alpha.-trifluoro-3,5 - dinitrotoluene-2,4-diaminedinoseb 2-sec-butyl-4,6-dinitrophenoldiphenamide N,N--dimethyl-2,2-diphenylacetamidedipropetryn 2-(ethylthio)-4,6-bis(isopropylamino)- .sub.-s-triazinediquat 6,7-dihydrodipyrido[1,2-.alpha.:2',1'-c]- pyrazinediium iondiuron 3-(3,4-dichlorophenyl)-1,1-dimethylureaDSMA disodium methanearsonateendothall 7-oxabicyclo[2.2.1]heptane-2,3-dicarbox- ylic aciderbon 2-(2,4,5-trichlorophenoxy)ethyl 2,2- dichloropropionateethafluralin N--ethyl-N--(2-methyl-2-propenyl)-2,6- dinitro-4-(trifluoromethyl)benzen- amineethofumesate (.+-.)-2-ethoxy-2,3-dihydro-3,3-dimethyl- 5-benzofuranyl methanesulfonatefenac (2,3,6-trichlorophenyl)acetic acidfenoxaprop ethyl 2-(4-(6-chloro-2-benzoxazolyl-ethyl oxy)phenoxy)propanoatefenuron 1,1-dimethyl-3-phenylureafenuron TCA 1,1-dimethyl-3-phenylurea mono(tri- chloroacetate)flamprop N--benzoyl-N--(3-chloro-4-fluorophenyl)- DL-alaninefluchloralin N--(2-chloroethyl)-2,6-dinitro-N--propyl- 4-(trifluoromethyl)anilinefluometuron 1,1-dimethyl-3-(.alpha.,.alpha.,.alpha.-trifluoro- .sub.--m-tol yl)- ureafluorodifen -p-nitrophenyl .alpha.,.alpha.,.alpha.-trifluoro-2-nitro- -p-tolyl etherfluridone 1-methyl-3-phenyl-5-[3-(trifluoro- methyl)phenyl]-4(1H)--pyridinonefomesafen 5-(2-chloro-4-trifluoromethylphenoxy)- N--methylsulfonyl-2-nitrobenzamidefosamine ethyl hydrogen (aminocarbonyl)phos- phonateglyphosate N--(phosphonomethyl)glycinehexaflurate potassium hexafluoroarsenatehexazinone 3-cyclohexyl-6-(dimethylamino)-1-methyl- 1,3,5-triazine-2,4(1H,3H)--dioneimazaquin 2-(4,5-dihydro-4-methyl-4-(1-methyl- ethyl)-5-oxo-1H--imidazol-2-yl)-3- quinolinecarboxylic acidioxynil 4-hydroxy-3,5-diiodobenzonitrileisopropalin 2,6-dinitro-N,N--dipropylcumidinekarbutilate tert-butylcarbamic acid ester with 3-( .sub.--m- hydroxyphenyl)-1,1-dimethylurealactofen 1'-(carboethoxy)ethyl-5-(2-chloro-4- (trifluoromethyl)phenoxy)-2-nitro- benzoatelenacil 3-cyclohexyl-6,7-dihydro-1H--cyclopenta- pyrimidine-2,4(3H,5H)--dionelinuron 3-(3,4-dichlorophenyl)-1-methoxy-1- methylureaMAA methanearsonic acidMAMA monoammonium methanearsonateMCPA [(4-chloro- -o-tolyl)oxy]acetic acidMCPB 4-[(4-chloro- -o-tolyl)oxy]butyric acidmecoprop 2-[(4-chloro- -o-tolyl)oxy]propionic acidmefluidide N--[(2,4-dimethyl-5-[[(trifluoromethyl)- sulfonyl]amino]phenyl]acetamidemethal- N--(2-methyl-2-propenyl)-2,6-dinitro-N--propalin propyl-4-(trifluoromethyl)benzenamidemethabenz- 1,3-dimethyl-3-(2-benzothiazolyl)ureathiazuronmetham sodium methyldithiocarbamatemethazole 2-(3,4-dichlorophenyl)-4-methyl-1,2,4- oxadiazolidine-3,5-dionemethoxuron N'--(3-chloro-4-methoxyphenyl)N,N-- dimethylureametolachlor 2-chloro-N--(2-ethyl-6-methylphenyl)-N-- (2-methoxy-1-methylethyl)acetamidemetribuzin 4-amino-6-tert-butyl-3-(methylthio)-as- triazine-5(4H)--onemetsulfuron 2-[[(4-methoxy-6-methyl-1,3,5-triazine-methyl 2-yl)aminocarbonyl]aminosulfonyl]ben- zoic acid, methyl estermolinate S--ethyl hexahydro-1H--azepine-1-carbo- thioatemonolinuron 3-( -p-chlorophenyl)-1-methoxy-1-methyl- ureamonuron 3-( -p-chlorophenyl)-1,1-dimethylureamonuron TCA 3-( -p-chlorophenyl-1,1-dimethylurea mono(trichloroacetate)MSMA monosodium methanearsonatenapropamide 2-(.alpha.-naphthoxy-N,N--diethylpropion- amidenaptalam N--1-naphthylphthalamic acidneburon 1-butyl-3-(3,4-dichlorophenyl)-1-methyl- ureanitralin 4-(methylsulfonyl)-2,6-dinitro-N,N-- dipropylanilinenitrofen 2,4-dichlorophenyl -p-nitrophenyl ethernitrofluorfen 2-chloro-1-(4-nitrophenoxy)-4-(tri- fluoromethyl)benzenenorea 3-(hexahydro-4,7-methanoindan-5-yl)-1,1- dimethylureanorflurazon 4-chloro-5-(methylamino)-2-(.alpha.,.alpha.,.alpha.-tri- fluoro- .sub.--m-tolyl)-3(2H)--pyridazinoneoryzalin 3,4-dinitro-N,N--dipropylsulfanilamideoxadiazon 2-tert-butyl-4-(2,4-dichloro-5-isopro- poxyphenyl).DELTA..sup.2 -1,3,4-oxadiazolin-5-oneoxyfluorfen 2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4- (trifluoromethyl)benzeneparaquat 1,1'-dimethyl-4,4'-bipyridinium ionPBA chlorinated benzoic acidpendimethalin N--(1-ethylpropyl)-3,4-dimethyl-2,6- dinitrobenzenamineperfluidone 1,1,1-trifluoro-N--[2-methyl-4-(phenyl- sulfonyl)phenyl]methanesulfonamidepicloram 4-amino-3,5,6-trichloropicolinic acidprocyazine 2-[[4-chloro-6-(cyclopropylamino)-1,3,5- triazine-2-yl]amino]-2-methylpropane- nitrileprofluralin N--(cyclopropylmethyl)-.alpha.,.alpha.,.alpha.-trifluoro- 2,6-dinitro-N--propyl- -p-toluidineprometon 2,4-bis(isopropylamino)-6-methoxy- .sub.-s- triazineprometryn 2,4-bis(isopropylamino)-6-(methylthio)- .sub.-s-triazinepronamide 3,5-dichloro N--(1,1-dimethyl-2-propyn- yl)benzamidepropachlor 2-chloro-N--isopropylacetanilidepropanil 3','-dichloropropionalidepropazine 2-chloro-4,6-bis(isopropylamino)- .sub.-s- triazinepropham isopropyl carbanilateprosulfalin N--[[4-(dipropylamino)-3,5-dinitro- phenyl]sulfonyl]-S,S--dimethylsulfil- imineprynachlor 2-chloro-N--(1-methyl-2-propynyl)acet- anilidequinofop 2-[4-(6-chloroquinoxalin-2-yloxy)phen-ethyl oxypropanoic acid, ethyl estersecbumeton N--ethyl-6-methoxy-N'(1-methylpropyl)- 1,3,5-triazine-2,4-diaminesethoxydim 2-[1-(ethoxyimino)butyl]-5-[2-(ethyl- thio)propyl]-3-hydroxy-2-cyclohexene- 1-onesiduron 1-(2-methylcyclohexyl)-3-phenylureasimazine 2-chloro-4,6-bis(ethylamino)- .sub.-s-triazinesimetryn 2,4-bis(ethylamino)-6-(methylthio)- .sub.-s- triazinesupriox 2-[1-(2,5-dimethylphenyl)ethylsulfonyl]- pyridine-N--oxideTCA trichloroacetic acidtebuthiuron N--[5-(1,1-dimethylethyl)-1,3,4-thiadi- azol-2-yl]-N,N'--dimethylureaterbacil 3-tert-butyl-5-chloro-6-methyluracilterbuchlor N--(butoxymethyl)-2-chloro-N--[2-(1,1- dimethylethyl)-6-methylphenyl]- acetamideterbuthyl- 2-(tert-butylamino)-4-chloro-6-(ethyl-azine amino)- .sub.-s-triazineterbutol 2,6-di-tert-butyl- -p-tolyl methylcar- bamateterbutryn 2-(tert-butylamino)-4-(ethylaminol-6- (methylthio- .sub.-s-triazinetetrafluron N,N--dimethyl-N'--[3-(1,1,2,2-tetrafluoro- ethoxy)phenyl]ureathiobencarb S--[(4-chlorophenyl)methyl]diethylcar- bamothioatetriallate S-- (2,3,3-trichloroallyl)diisopropylthio- carbamatetrifluralin .alpha.,.alpha.,.alpha.-trifluoro-2,6-dinitro-N,N--propyl- -p-toluidinetrimeturon 1-( -p-chlorophenyl)-2,3,3-trimethylpseu- doureavernolate S--propyl dipropylrhiocarbamate ethyl 5-[2-chloro-4-(trifluoromethyl)- phenoxy]-2-nitrobenzoic acid2,3,6-TBA.sup.b 2,3,6-trichlorobenzoic acid2,4-D (2,4-dichlorophenoxy)acetic acid2,4-DB 4-(2,4-dichlorophenoxy)butyric acid2,4-DEP tris[2-(2,4-dichlorophenoxy)ethyl] phosphite______________________________________Trade Name orCode Number Chemical Name______________________________________"Cinch" exo-1-methyl-4-(1-methylethyl)-2-[(2- methylphenyl)methoxy]-7-oxabicyclo- [2.2.1]heptaneAC 263,499 2-[4,5-dihydro-4-methyl-4-(1-methyl- ethyl)-5-oxo-1H--imidazol-2-yl]-5- ethyl-3-pyridinecarboxylic acidHarmony .TM. 3-[[(4-methoxy-6-methyl-1,3,5-triazin- 2-yl)aminooarbonyl]aminosulfonyl]-2- thiophenecarboxylic acid, methyl esterPPG-1013 5-(2-chloro-4-(trifluoromethyl)phenoxy)- 2-nitroacetophenone oxime-O--acetic acid, methyl esterDOWCO 453 ME 2-(4-(3-chloro-5-trifluoromethylpyridin- 2-yloxy)phenoxy)propanoic acid, methyl esterFMC 57020 2-(2'-chlorophenyl)methyl-4,4-dimethyl- 3-isoxazolidinoneAC 222,293 6-(4-isopropyl-4-methyl-5-oxo-2-imid- azolin-2-yl)- .sub.--m-toluic acid, methyl ester and 6-(4-isopropyl-4-methyl-5- oxo-2-imidazolin-2-yl- -p-toluic acid, methyl esterAC 252,925 2-(4-isopropyl-4-methyl-5-oxo-2-imidazo- lin-2-yl)nicotinic acid with isopropyl amine (1:1)DPX-L53OO 2-[[N--(4-methoxy-6-methyl-1,3,5-tria- zine-2-yl)-N--methylaminocarbonyl]- aminosulfonyl]benzoic acid, methyl ester______________________________________
The compound of the present invention is of particular utility for selective control of grass and broadleaf weeds in rice. The compound of the present invention is especially useful for selective control of grass and broadleaf weeds in Japonica rice. The compound of this invention is also especially useful in combinatiion with the following herbicides.
______________________________________Common Name Chemical name______________________________________butachlor N--(butoxymethyl)-2-chloro-2',6'-diethyl- acetanilidedimepiperate S--(1-methyl-1-phenethyl)piperidine-1- carbothiolateesprocarb S--[(phenyl)methyl]-N--ethyl-N--(1,2- dimethylpropyl)carbamothioatemefenacet 2-(benzothiazol-2-yloxy)-N--methyl-N-- phenylacetamidemolinate S-ethyl hexahydro-lH--azepine-1-carbo- thiolatepretilachlor 2-chloro-2',6'-diethyl-N--(2-propoxy- ethyl)acetanilidequinclorac 3,7-dichloro-8-quinoline carboxylic acidthiobencarb S--[(4-chlorophenyl)methyl]diethylcar- bamothioate______________________________________
The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow.
Test A
Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloa crusgalli), wild oats (Avena fatua), cheatgrass (Bromus secalinus), sicklepod (Cassia obtusifolia), morningglory (Ipomoea sp.), cocklebur (Xanthium sp.), velvetleaf (Abutilon theophrasti), sorghum, corn, soybean, sugar beet, cotton, rice, wheat and purple nutsedge (Cyperus rotundus) tubers were planted and treated preemergence with the test chemicals dissolved in a non-phytotoxic solvent. The the same time, these crop and weed species were treated with a soil/foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table 1, are based on a numerical scale extending from 0=no injury, to 10=complete kill. The accompanying descriptive symbols have the following meanings:
______________________________________B = burn;C = chlorosis/necrosis;D = defoliation;E = emergence inhibition;G = growth retardation;H = formative effects;U = unusual pigmentation;S = albinism; and6Y = abscised buds or flowers.-- = no test______________________________________
__________________________________________________________________________ ##STR32##Cmpd. R R.sub.1 R.sub.2 X Y Z__________________________________________________________________________1 H CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 OCH.sub.3 CH2 H CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 CH.sub.3 N3 H CH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 N4 H CH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 CH.sub.3 CH5 H CH.sub.3 OC.sub.2 H.sub.5 CH.sub.3 OCH.sub.3 CH6 H CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 Cl CH7 H CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 OCH.sub.3 N8 H CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 OCH.sub.2 CF.sub.3 N9 H CH.sub.3 OC.sub.2 H.sub. 5 OCH.sub.3 N(CH.sub.3).sub.2 N10 CH.sub.3 CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 CH.sub.3 N11 H CH.sub.3 SCH.sub.3 OCH.sub.3 OCH.sub.3 CH12 CH.sub.3 CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 OCH.sub.3 CH13 CH.sub.3 CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 OCH.sub.3 N14 H CH.sub.3 OC.sub.2 H.sub.5 OCH.sub.3 N(CH.sub.3).sub.2 CH15 H CH.sub.3 OCH.sub.2 CHCH.sub.2 OCH.sub.3 CH.sub.3 N__________________________________________________________________________
TABLE 1______________________________________ Cmpd. 1 Cmpd. 2 Cmpd. 3Rate kg/ha 0.05 0.05 0.05______________________________________POSTEMERGENCEMorningglory 6C,9G 10C 9CCocklebur 9C 10C 10CSicklepod 9C 9C 9CNutsedge 2C,8G 8G 2C,8GCrabgrass 4G 5G 6GBarnyardgrass 5C,9H 5C,9H 5C,9GWild Oats 3C,5G 6C,9G 2C,9GWheat 3C,6G 7C,9G 2C,9GCorn 2C,9G 9G 9GSoybean 5C,9G 9C 9CRice 5C,9G 6C,9G 5C,9GSorghum 4C,9H 3C,9G 2C,9GSugar beet 9C 5C,9G 5C,9GCotton 9C 9C 9CVelvetleaf -- -- --Cheatgrass -- -- --PREEMERGENCEMorningglory 9G 9G 9GCocklebur 9H 5C,9H 9HSicklepod 8G 9G 4C,8GNutsedge 9G 8G 7GCrabgrass 5G 4G 3GBarnyardgrass 2C,7G 5G 3C,6GWild Oats 2C,6G 4C,8H 3C,7HWheat 9H 5C,9H 3C,9HCorn 2C,8G 8H 8GSoybean 2C,3H 9H 3C,6HRice 5C,9G 10E 10ESorghum 3C,9G 7C,9H 3C,9HSugar beet 3C,9G 5C,9G 5C,9GCotton 2C,9G 9G 9GVelvetleaf -- -- --Cheatgrass -- -- --______________________________________ Cmpd. 4 Cmpd. 5 Cmpd. 6 Cmpd. 7Rate kg/ha 0.05 0.05 0.05 0.05______________________________________POSTEMERGENCEMorningglory 9C 6C,9G 9C 6C,9GCocklebur 10C 5C,9G 10C 10CSicklepod 9C 6C,9G 4C,9G 9CNutsedge 2C,9G 8G 9G 5GCrabgrass 8G 6G 0 3GBarnyardgrass 5C,9H 5C,9H 3C,5H 3C,7HWild Oats 2C,9G 2C,8G 4G 5C,9GWheat 3C,9G 3C,8G 2G 5GCorn 9G 9G 3C,7H 2C,3HSoybean 4C,9G 6C,9G 4C,9H 4C,9GRice 5C,9G 5C,9G 3C,9G 5C,9GSorghum 3C,9H 3C,9G 9H 9GSugar beet 9C 5C,9G 5C,9G 9CCotton 9C 9C 9C 9CVelvetleaf -- -- -- --Cheatgrass -- -- -- --PREEMERGENCEMorningglory 9G 9G 9G 9GCocklebur 9H 9H 3C,8H 9HSicklepod 8G 2C,8G 8G 8GNutsedge 10E 8G 10E 8GCrabgrass 5G 6G 2G 6GBarnyardgrass 9H 5C,9H 3C,5G 3C,3GWild Oats 3C,8G 4C,8G 2C,4G 4C,6GWheat 2C,9H 3C,9H 5G 6GCorn 9H 9G 7G 1C,7GSoybean 8H 9H 7H 8HRice 10E 10E 9H 10ESorghum 4C,9H 5C,9H 5C,9H 5C,9HSugar beet 4C,9G 4C,9G 4C,8G 4C,9GCotton 9G 9G 9G 9GVelvetleaf -- -- -- --Cheatgrass -- -- -- --______________________________________ Cmpd. 8 Cmpd. 9 Cmpd. 10Rate kg/ha 0.05 0.05 0.05______________________________________POSTEMERGENCEMorningglory 10C 10C 5C,9GCocklebur 9C 10C 10CSicklepod 9C 9C 1CNutsedge 2C,8G 7G 3GCrabgrass 0 0 0Barnyardgrass 3H 3H 3HWild Oats 4G 3C,9G 2C,8GWheat 4G 2C,8G 5GCorn 7H 2C,8H 1HSoybean 5C,9G 5C,9G 5C,9GRice 5C,9G 5C,9G 6C,9GSorghum 3C,8H 4C,9G 2U,9HSugar beet 10C 10C 9CCotton 3C,8G 10C 5C,9GVelvetleaf -- -- --Cheatgrass -- -- --PREEMERGENCEMorningglory 9G 9G 7GCocklebur 8H 8H 8GSicklepod 2C 3G 1CNutsedge 0 0 0Crabgrass 0 0 0Barnyardgrass 0 3C,3H 2CWild Oats 2C,6G 2C,7G 3GWheat 6G 6G 3GCorn 7G 5G 2GSoybean 4C,7H 3G 0Rice 4C,8H 3C,6G 3C,8HSorghum 3C,7G 2C,8G 2GSugar beet 5C,9G 4C,9G 3C,9GCotton 3G 3G 2GVelvetleaf -- -- --Cheatgrass -- -- --______________________________________ Cmpd. 11Rate kg/ha 0.05______________________________________POSTEMERGENCEMorningglory 9CCocklebur 9CSicklepod 9CNutsedge 6C,9GCrabgrass 4C,9GBarnyardgrass 9CWild Oats 9CWheat 9CCorn 9CSoybean 5C,9GRice 5C,9GSorghum 5C,9GSugar beet 9CCotton 3C,9GVelvetleaf --Cheatgrass --PREEMERGENCEMorningglory 9GCocklebur 9HSicklepod 9GNutsedge 10ECrabgrass 6C,9GBarnyardgrass 6C,9HWild Oats 6C,9GWheat 9CCorn 2C,9HSoybean 9HRice 10ESorghum 4C,9HSugar beet 5C,9GCotton 9GVelvetleaf --Cheatgrass --______________________________________ Cmpd. 12 Cmpd. 13 Cmpd. 14 Cmpd. 15Rate kg/ha 0.05 0.05 0.05 0.05______________________________________POSTEMERGENCEMorningglory 3C,6G 9C 5C,9G 10CCocklebur 4G 5C,9G 2C,8H 9CSicklepod 0 1C 3C,3H --Nutsedge 0 0 0 4GCrabgrass 0 0 2G 5HBarnyardgrass 2H 3C,3H 2C,8H 5C,8HWild Oats 0 2C,6G 6G 9CWheat 0 2G 0 10CCorn 5G 0 2C,8H 10CSoybean 3C,6G 5C,9G 3C,8G 9CRice 4C,8G 5C,9G 2C,5G 9CSorghum 3C,8G 5G 3C,8H 9CSugar beet 3C,8G 9C 5C,9G 9CCotton 9C 9C 5C,9G 10CVelvetleaf -- -- -- 9CCheatgrass -- -- -- 6C,9GPREEMERGENCEMorningglory 0 8G 2C,6G 9GCocklebur 0 8H 2C,5H 9HSicklepod 0 0 2C --Nutsedge 0 0 10E 8GCrabgrass 0 0 3G 2C,5GBarnyardgrass 0 1H 3C,8H 4C,5GWild Oats 0 0 2C,7G 3C,8GWheat 0 0 2C,7G 8GCorn 0 5G 2C,8G 3U,6GSoybean 0 3C,2H 3C,3H 2C,6GRice 2G 3C,8H 5G 8HSorghum 2G 2C,5G 3C,8G 4U,8GSugar beet 2G 8G 9C 9CCotton 0 7G 0 9GVelvetleaf -- -- -- 9CCheatgrass -- -- -- 4C,8G______________________________________
TEST B
Postemergence
Two round pans (25 cm diameter by 12.5 cm deep) were filled with Woodstown sandy loam soil. One path was planted with blackgrass (Alopecurus myosuroides), sugar beets, nutsedge (Cyperus rotundus) tubers, crabgrass (Digitaria sanguinalis), sicklepod (Cassia obtusifolia), teaweed (Sida spinosa), jimsonweed (Datura stramonium), velvetleaf (Abutilon theophrasti), and giant foxtail (Setaria faberii). The other pan was planted with wheat, cotton, rice, corn, soybean, wild oats (Avena fatua), cocklebur (Xanthium pensylvanicum), morningglory (Ipomoea hederacea), johnsongrass (Sorghum halepense) and barnyardgrass (Echinochloa crusgalli). The plants were grown for approximately fourteen days, then sprayed postemergence with the chemicals dissolved in a non-phytotoxic solvent.
Preemergence
Two round pans (25 cm diameter by 12.5 cm deep) were filled with Woodstown sandy loam soil. One pan was planted with blackgrass, sugar beets, nutsedge, crabgrass, sicklepod, teaweed, jimsonweed, velvetleaf, and giant foxtail. The other pan was planted with wheat, cotton, rice, corn, soybeans, wild oats, cocklebur, morningglory, johnsongrass, and barnyardgrass. The two pans were sprayed preemergence with the chemicals dissolved in a non-phytotoxic solvent.
Treated plants and controls were maintained in the greenhouse for 28 days, then all treated plants were compared to controls and visually rated for plant response.
Response ratings are based on a scale of 0 to 10: where 0=no effect, and 10=complete control. The type of response is indicated by letters as described for Test 1. A dash (-) response means no test.
Response ratings are contained in Table 2.
TABLE 2______________________________________POSTEMERGENCE Compound 1Rate g/ha 62 16 4 1______________________________________Corn 8G 2G 0 0Wheat 0 0 0 0Rice 8G 2G 0 0Soybean 10G 9G 7G 3GCotton 10G 9G 9G 3GSugar beet 10G 10G 9G 6GCrabgrass 7G 4G 0 0Johnsongrass 10G 9G 8G 3GBlackgrass 10G 10G 8G 0Barnyardgrass 2G 0 0 0Nutsedge 7G 3G 0 0Giant Foxtail 2G 0 0 0Wild Oats 0 0 0 0Cocklebur 10G 9G 9G 7GMorningglory 10G 9G 8G 4GTeaweed 9G 8G 3G 0Sicklepod 10G 9G 5G 0Jimsonweed 10G 8G 6G 2GVelvetleaf 10G 10G 8G 5G______________________________________PREEMERGENCERate g/ha 250 62 16______________________________________Corn 6G 3G 0Wheat 5G 0 0Rice 9G 8G 7GSoybean 7G 2G 0Cotton 8G 3G 0Sugar beet 9G 8G 3GCrabgrass 7G 3G 0Johnsongrass 9G 9G 5GBlackgrass 9G 9G 8GBarnyardgrass 6G 2G 0Nutsedge 8G 2G 0Giant Foxtail 9G 4G 0Wild Oats 7G 2G 0Cocklebur 8G 4G 2GMorningglory 9G 6G 2GTeaweed 9G 8G 2GSicklepod 9G 7G 2GJimsonweed 9G 4G 0Velvetleaf 10G 9G 7G______________________________________POSTEMERGENCE Compound 2Rate g/ha 62 16 4 1______________________________________Corn 7G 4G 2G 0Wheat 9G 5G 0 0Rice 10G 10G 5G 0Soybean 10G 9G 6G 3GCotton 10G 10G 9G 2GSugar beet 10G 10G 10G 9GCrabgrass 7G 3G 0 0Johnsongrass 10G 9G 8G 2GBlackgrass 10G 10G 8G 5GBarnyardgrass 8G 6G 4G 0Nutsedge 8G 6G 3G 0Giant Foxtail 6G 0 0 0Wild Oats 10G 9G 4G 0Cocklebur 10G 10G 9G 7GMorningglory 10G 10G 9G 7GTeaweed 9G 4G 0 0Sicklepod 10G 9G 8G 2GJimsonweed 10G 10G 9G 3GVelvetleaf 10G 9G 9G 5G______________________________________PREEMERGENCERate g/ha 250 62 16 4______________________________________Corn 9G 7G 6G 2GWheat 10G 9G 2G 0Rice 10E 10E 10G 9GSoybean 10G 9G 8G 2GCotton 10G 8G 3G 0Sugar beet 10G 10G 10G 7GCrabgrass 8G 3G 0 0Johnsongrass 10G 9G 8G 4GBlackgrass 10E 10G 10G 9GBarnyardgrass 8G 7G 5G 0Nutsedge 9G 8G 3G 0Giant Foxtail 10G 9G 7G 2GWild Oats 10G 9G 9G 7GCocklebur 9G 9G 7G 5GMorningglory 10G 9G 6G 3GTeaweed 9G 9G 8G 3GSicklepod 10G 9G 7G 2GJ1msonweed 10G 9G 9G 5GVelvetleaf 10G 10G 9G 5G______________________________________POSTEMERGENCE Compound 3Rate g/ha 62 16 4Corn 8G 2G 0Wheat 5G 0 0Rice 10G 9G 5GSoybean 10G 9G 7GCotton 10G 9G 5GSugar beet 10G 9G 8GCrabgrass 7G 6G 2GJohnsongrass 10G 8G 2GBlackgrass 10G 8G 6GBarnyardgrass 9G 7G 3GNutsedge 6G 0 0Giant Foxtail 4G 0 0Wild Oats 9G 8G 0Cocklebur 10G 9G 8GMorningglory 10G 8G 4GTeaweed 9G 8G 2GSicklepod 9G 8G 3GJimsonweed 9G 9G 3GVelvetleaf 9G 8G 7G______________________________________PREEMERGENCERate g/ha 250 62 16 4______________________________________Corn 9G 6G 2G 0Wheat 8G 7G 2G 0Rice 10E 10E 9G 7GSoybean 9G 7G 5G 3GCotton 10G 9G 6G 3GSugar beet 10G 9G 9G 7GCrabgrass 6G 0 0 0Johnsongrass 9G 8G 6G 3GBlackgrass 10G 10G 9G 8GBarnyardgrass 10G 8G 5G 3GNutsedge 10G 8G 3G 0Giant Foxtail 9G 7G 4G 0Wild Oats 10G 9G 9G 3GCocklebur 9G 8G 7G 3GMorningglory 9G 9G 5G 2GTeaweed 9G 9G 6G 2GSicklepod 10G 9G 3G 0Jimsonweed 10G 9G 8G 3GVelvetleaf 10G 10G 9G 5G______________________________________POSTEMERGENCE Compound 4Rate g/ha 62 16 4 1Corn 8G 5G 0 0Wheat 7G 3G 0 0Rice 10G 9G 6G 0Soybean 10G 10G 7G 3GCotton 9G 8G 3G 0Sugar beet 10G 10G 8G 6GCrabgrass 9G 8G 6G 0Johnsongrass 10G 10G 8G 3GBlackgrass 10G 10G 8G 7GBarnyardgrass 10G 9G 5G 4GNutsedge 9G 7G 3G 0Giant Foxtail 9G 8G 2G 0Wild Oats 9G 8G 0 0Cocklebur 10G 10G 9G 4GMorningglory 9G 5G 0 0Teaweed 9G 9G 7G 2GSicklepod 9G 9G 9G 5GJimsonweed 10G 9G 6G 3GVelvetleaf 10G 9G 9G 5G______________________________________PREEMERGENCERate g/ha 250 62 16 4Corn 10G 7G 2G 0Wheat 9G 7G 2G 0Rice 10E 9G 9G 6GSoybean 10G 8G 5G 2GCotton 9G 9G 8G 0Sugar beet 10G 9G 7G 2GCrabgrass 9G 8G 5G 0Johnsongrass 9G 9G 9G 7GBlackgrass 10G 9G 9G 7GBarnyardgrass 9G 9G 8G 4GNutsedge 9G 8G 6G 0Giant Foxtail 10E 10E 9G 3GWild Oats 9G 9G 8G 6GCocklebur 9G 9G 7G 0Morningglory 9G 8G 6G 0Teaweed 9G 9G 6G 0Sicklepod 9G 9G 6G 0Jimsonweed 9G 8G 5G 2GVelvetleaf 10G 9G 7G 5G______________________________________POSTEMERGENCE Compound 6Rate g/ha 62 16 4______________________________________Corn 2G 0 0Wheat 0 0 0Rice 8G 2G 0Soybean 7G 4G 2GCotton 9G 5G 3GSugar beet 10G 10G 6GCrabgrass 7G 3G 0Johnsongrass 9G 7G 2GBlackgrass 10G 9G 6GBarnyardgrass 7G 3G 0Nutsedge 0 0 0Giant Foxtail 6G 0 0Wild Oats 0 0 0Cocklebur 10G 9G 6GMorningglory 10G 9G 4GTeaweed 8G 6G 2GSicklepod 9G 9G 2GJimsonweed 10G 8G 3GVelvetleaf 10G 9G 6G______________________________________PREEMERGENCERate g/ha 62 16______________________________________Corn 2G 0Wheat 0 0Rice 9G 7GSoybean 0 0Cotton 4G 0Sugar beet 7G 2GCrabgrass 0 0Johnsongrass 7G 3GBlackgrass 10G 9GBarnyardgrass 0 0Nutsedge 8G 5GGiant Foxtail 0 0Wild Oats 4G 0Cocklebur 5G 2GMorningglory 7G 2GTeaweed 6G 3GSicklepod 2G 0Jimsonweed 7G 3GVelvetleaf 8G 6G______________________________________POSTEMERGENCE Compound 7Rate g/ha 62 16 4 1______________________________________Corn 2G 0 0 0Wheat 2G 0 0 0Rice 9G 5G 2G 0Soybean 10C 9G 8G 4GCotton 10C 8G 5G 0Sugar beet 10C 10C 10C 7CCrabgrass 0 0 0 0Johnsongrass 8G 5G 4G 0Blackgrass 10C 8C 5G 0Barnyardgrass 3 0 0 0Nutsedge 0 0 0 0Giant Foxtail 0 0 0 0Wild Oats 5G 3G 0 0Cocklebur 10G 10G 9G 7GMorningglory 10C 10C 10G 7GTeaweed 8G 8G 3G 0Sicklepod 10C 10G 5G 0Jimsonweed 10G 10G 5G 0Velvetleaf 7G 3G 0 0______________________________________PREEMERGENCERate g/ha 250 62 16 4______________________________________Corn 2G 0 0 0Wheat 4G 2G 0 0Rice 10E 9G 9G 4GSoybean 10G 6G 2C 0Cotton 10G 9G 4G 0Sugar beet 10G 9G 8G 4GCrabgrass 0 0 0 0Johnsongrass 7G 4G 0 0Blackgrass 10G 9G 7G 3GBarnyardgrass 2G 0 0 0Nutsedge 3G 0 0 0Giant Foxtail 0 0 0 0Wild Oats 8G 7G 3G 0Cocklebur 10G 9G 8G 4GMorningglory 9G 8G 4G 0Teaweed 10G 9G 5G 0Sicklepod 10E 9G 5G 0Jimsonweed 10G 8G 4G 0Velvetleaf 7G 4G 0 0______________________________________POSTEMERGENCE Compound 11Rate g/ha 250 62 16 4 1______________________________________Corn 100 100 100 90 60Wheat 100 100 90 50 0Rice 100 100 100 90 60Soybean 100 100 100 90 80Cotton 100 70 20 0 0Sugar beet 100 100 100 100 90Rape 100 100 100 100 80Crabgrass 100 90 70 20 0Johnsongrass 100 100 100 90 80Blackgrass 100 100 100 100 90Barnyardgrass 100 100 100 80 0Nutsedge 100 100 100 90 50Giant Foxtail 100 100 100 70 0Wild Oats 100 100 90 70 20Cocklebur 100 100 90 60 20Morningglory 100 100 100 100 90Teaweed 100 70 20 0 0Sicklepod 100 100 100 70 20Jimsonweed 100 100 100 90 60Velvetleaf 100 100 90 90 30______________________________________PREEMERGENCERate g/ha 62 16 4______________________________________Corn 100 100 30Wheat 100 90 30Rice 100 100 90Soybean 95 70 40Cotton 40 20 0Sugar beet 100 100 80Rape 100 100 90Crabgrass 100 90 50Johnsongrass 100 100 90Blackgrass 100 100 90Barnyardgrass 100 100 70Nutsedge 100 100 70Giant Foxtail 100 100 90Wild Oats 100 90 40Cocklebur 95 90 20Morningglory 90 80 30Teaweed 90 60 30Sicklepod 90 60 30Jimsonweed 100 100 lo0 30Velvetleaf 100 60 30______________________________________
Test C
Sixteen-cm diameter Wagner pots, equipped with a stoppered drain opening near the bottom of the side wall, were filled with Woodstown sandy loam. About 1500 ml of water were added to each pot to bring the water level to a point 3 cm above the soil surface. Japonica and Indica rice seedlings were transplanted. Also, a number of barnyardgrass (Echinochloa crusgalli) seeds were added to each pot. At the same time, seeds were added to each pot. At the same time, seedlings or tubers of the following species were transplanted into the muddy soil: water plaintain (Alisma trivale), Scirpus (Scirpus mucranatus) and Cyperus (Cyperus difformis). The weed species selected for this test are of economic importance in major rice-growing areas. The chemical treatments were applied within hours after transplanting two additional species selected from: water chestnut (Eleocharis spp.), arrowhead (Sagittaria latifolia) and pond plant (Potamogeton Americanus). Shortly after treatment, the drain hold was opened to drop the water level by two cm. Water was then added to restore the water level to its original height. The following day the draining and refilling process was repeated. The pots were then maintained in the greenhouse. Rates of application and plant response ratings made 21 days after treatment are summarized in Table 3.
These test results demonstrate the utility of compound 16 for weed control in rice. The results also show utility for Japonica rice and Indica rice. Useful rates of applicatiion range from 4-2000 g/ha with 4-32 g being preferred and 8-16 g being most preferred.
TABLE 3______________________________________Compound 16 ##STR33##______________________________________Rate (g/ha) 8 30______________________________________Japonica Rice 5 17Indica Rice 0 20Barnyardgrass 65 85Waterchestnut 87 97Arrowhead 92 95Scirpus 65 72Cyperus 100 100Water Plaintain 75 90______________________________________Rate (g/ha) 8 16 30 63______________________________________Japonica Rice 0 5 0 17Indica Rice 7 10 0 32Barnyardgrass 80 90 85 95Arrowhead 87 95 95 100Scirpus 87 92 87 95Cyperus 100 100 100 100Water Plaintain 90 90 95 100Pond Plant 97 100 100 100______________________________________

Number	Name	Date
4383113	Levitt	May 1983
4394506	Levitt	Jul 1983
4452628	Adams, Jr.	Jun 1984
4476321	Meyer et al.	Oct 1984
4514212	Meyer et al.	Apr 1985
4536576	Levitt	Aug 1983
4537619	Meyer	Aug 1985
4545811	Meyer	Oct 1985
4561878	Meyer	Dec 1985
4710221	Hilleman	Dec 1987

Number	Date	Country
0007687	Feb 1980	EPX
0044808	Jan 1982	EPX
0084020	Jul 1983	EPX
0124295	Nov 1984	EPX
814874	Jan 1982	ZAX
825042	Jan 1983	ZAX
825671	Feb 1983	ZAX
827439	Apr 1983	ZAX
830441	Jul 1983	ZAX
833779	Sep 1983	ZAX
836449	Feb 1984	ZAX
842245	Sep 1984	ZAX
842722	Oct 1984	ZAX

	Number	Date
Parent	801165	Nov 1985
Parent	720702	Apr 1985
Parent	613412	May 1987

Herbicidal sulfonamides

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