HEROIN REPLACEMENT THERAPY WITH TRANSDERMAL METHADONE

Information

  • Research Project
  • 3494173
  • ApplicationId
    3494173
  • Core Project Number
    R43DA004251
  • Full Project Number
    1R43DA004251-01
  • Serial Number
    4251
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/30/1986 - 38 years ago
  • Project End Date
    6/30/1987 - 37 years ago
  • Program Officer Name
  • Budget Start Date
    9/30/1986 - 38 years ago
  • Budget End Date
    6/30/1987 - 37 years ago
  • Fiscal Year
    1986
  • Support Year
    1
  • Suffix
  • Award Notice Date
    -

HEROIN REPLACEMENT THERAPY WITH TRANSDERMAL METHADONE

Methadone hydrochloride is widely used in drug treatment of heroin addicts and effectively relieves the craving for heroin. However, methadone is itself addictive and a drug of abuse. As a result, diversion of methadone to the black market by patients is a serious problem and the drug cannot usually be given to patients for self-medication. There is reason to believe that methadone free base would be sufficiently skin permeable to allow administration as a transdermal patch, especially if the drug is administered with a skin permeation enhancer such as ethanol or propanol. We propose to develop such a system. Because methadone in a transdermal patch compounded with unpalatable excipient would not be open to abuse, this approach could allow innovations in drug treatment programs to be attempted. In the proposed Phase I program, the permeability of skin to methadone free base with and without skin permeation enhancers would be determined. If these results are sufficiently encouraging, transdermal devices would be developed in Phase II program and a collaborative effort with a clinical researcher leading to the submission of an IND undertaken.

IC Name
NATIONAL INSTITUTE ON DRUG ABUSE
  • Activity
    R43
  • Administering IC
    DA
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    SRCD
  • Study Section Name
  • Organization Name
    MEMBRANE TECHNOLOGY AND RESEARCH, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    MENLO PARK
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    94025
  • Organization District
    UNITED STATES