Claims
- 1. A vaccine composition comprising a recombinantly produced glycosylated glycoprotein B (gB) polypeptide of Herpes Simplex Virus (HSV) that has a deletion of all or a portion of the transmembrane anchor region, in combination with a pharmacologically acceptable carrier and an adjuvant.
- 2. A vaccine according to claim 1 wherein said adjuvant is selected from the group consisting of aluminum hydroxide, muramyl dipeptide and muramyl dipeptide derivatives.
- 3. A method for immunizing a human against HSV comprising vaccinating the human with the vaccine of claim 1.
- 4. A method according to claim 3, wherein the vaccination is given prior to primary infection with Herpes Simplex virus.
- 5. A method according to claim 3, wherein the vaccination is given subsequent to primary infection with Herpes Simplex virus.
- 6. A vaccine according to claim 1, wherein the HSV is HSV-1.
- 7. A method for immunizing a human against HSV comprising vaccinating the human with the vaccine of claim 6.
- 8. A method according to claim 7, wherein the vaccination is given prior to a primary infection with Herpes Simplex virus.
- 9. A method according to claim 7, wherein the vaccination is given subsequent to a primary infection with Herpes Simplex virus.
- 10. A vaccine according to claim 1, wherein the HSV is HSV-2.
- 11. A method for immunizing a human against HSV comprising vaccinating the human with the vaccine of claim 10.
- 12. A method according to claim 11, wherein the vaccination is given prior to primary infection with Herpes Simplex virus.
- 13. A method according to claim 11, wherein the vaccination is given subsequent to primary infection with Herpes Simplex virus.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation of application Ser. No. 08/138,717 filed on 18 Oct. 1993, now abandoned, which is a continuation of application Ser. No. 07/993,415 filed 21 Dec. 1992, now abandoned, which is a divisional of application Ser. No. 07/587,179 filed 20 Sep. 1990, now U.S. Pat. No. 5,244,792, which is a continuation of application Ser. No. 06/921,730 filed 20 Oct. 1986, now abandoned, which is a continuation-in-part of application Ser. No. 06/597,784 filed 6 Apr. 1984, now abandoned.
US Referenced Citations (7)
Foreign Referenced Citations (2)
Number |
Date |
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133063 |
Feb 1985 |
EPX |
135841 |
Apr 1985 |
EPX |
Divisions (1)
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587179 |
Sep 1990 |
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Continuations (3)
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138717 |
Oct 1993 |
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993415 |
Dec 1992 |
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921730 |
Oct 1986 |
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Continuation in Parts (1)
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597784 |
Apr 1984 |
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