HETERO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES

FIELD OF APPLICATION OF THE INVENTION

The invention relates to substituted oxa-, thia- or aza-tetrahydro-4H-indol-4-one compounds, uses thereof and processes for their production.

BACKGROUND OF THE INVENTION

One of the most fundamental characteristics of cancer cells is their ability to sustain chronic proliferation whereas in normal tissues the entry into and progression through the cell division cycle is tightly controlled to ensure a homeostasis of cell number and maintenance of normal tissue function. Loss of proliferation control was emphasized as one of the six hallmarks of cancer [Hanahan D and Weinberg R A, Cell 100, 57, 2000; Hanahan D and Weinberg R A, Cell 144, 646, 2011].

The eukaryotic cell division cycle (or cell cycle) ensures the duplication of the genome and its distribution to the daughter cells by passing through a coordinated and regulated sequence of events. The cell cycle is divided into four successive phases:

1. The G1 phase represents the time before the DNA replication, in which the cell grows and is sensitive to external stimuli.
2. In the S phase the cell replicates its DNA, and
3. in the G2 phase preparations are made for entry into mitosis.
4. In mitosis (M phase), the duplicated chromosomes get separated supported by a spindle device built from microtubules, and cell division into two daughter cells is completed.

To ensure the extraordinary high fidelity required for an accurate distribution of the chromosomes to the daughter cells, the passage through the cell cycle is strictly regulated and controlled. The enzymes that are necessary for the progression through the cycle must be activated at the correct time and are also turned off again as soon as the corresponding phase is passed. Corresponding control points (“checkpoints”) stop or delay the progression through the cell cycle if DNA damage is detected, or the DNA replication or the creation of the spindle device is not yet completed. The mitotic checkpoint (also known as spindle checkpoint or spindle assembly checkpoint) controls the accurate attachment of mircrotubules of the spindle device to the kinetochors (the attachment site for microtubules) of the duplicated chromosomes. The mitotic checkpoint is active as long as unattached kinetochores are present and generates a wait-signal to give the dividing cell the time to ensure that each kinetochore is attached to a spindle pole, and to correct attachment errors. Thus the mitotic checkpoint prevents a mitotic cell from completing cell division with unattached or erroneously attached chromosomes [Suijkerbuijk S J and Kops G J, Biochem. Biophys. Acta 1786, 24, 2008; Musacchio A and Salmon E D, Nat. Rev. Mol. Cell. Biol. 8, 379, 2007]. Once all kinetochores are attached with the mitotic spindle poles in a correct bipolar (amphitelic) fashion, the checkpoint is satisfied and the cell enters anaphase and proceeds through mitosis.

The mitotic checkpoint is established by a complex network of a number of essential proteins, including members of the MAD (mitotic arrest deficient, MAD 1-3) and Bub (Budding uninhibited by benzimidazole, Bub 1-3) families, Mps1 kinase, cdc20, as well as other components [reviewed in Bolanos-Garcia V M and Blundell T L, Trends Biochem. Sci. 36, 141, 2010], many of these being over-expressed in proliferating cells (e.g. cancer cells) and tissues [Yuan B et al., Clin. Cancer Res. 12, 405, 2006]. The major function of an unsatisfied mitotic checkpoint is to keep the anaphase-promoting complex/cyclosome (APC/C) in an inactive state. As soon as the checkpoint gets satisfied the APC/C ubiquitin-ligase targets cyclin B and securin for proteolytic degradation leading to separation of the paired chromosomes and exit from mitosis.

Inactive mutations of the Ser/Thr kinase Bub1 prevented the delay in progression through mitosis upon treatment of cells of the yeast S. cerevisiae with microtubule-destabilizing drugs, which led to the identification of Bub1 as a mitotic checkpoint protein [Roberts B T et al., Mol. Cell Biol., 14, 8282, 1994]. A number of recent publications provide evidence that Bub1 plays multiple roles during mitosis which have been reviewed by Elowe [Elowe S, Mol. Cell. Biol. 31, 3085, 2011]. In particular, Bub1 is one of the first mitotic checkpoint proteins that binds to the kinetochores of duplicated chromosomes and probably acts as a scaffolding protein to constitute the mitotic checkpoint complex. Furthermore, via phosphorylation of histone H2A, Bub1 localizes the protein shugoshin to the centromeric region of the chromosomes to prevent premature segregation of the paired chromosomes [Kawashima et al. Science 327, 172, 2010]. In addition, together with a Thr-3 phosphorylated Histone H3 the shugoshin protein functions as a binding site for the chromosomal passenger complex which includes the proteins survivin, borealin, INCENP and Aurora B. The chromosomal passenger complex is seen as a tension sensor within the mitotic checkpoint mechanism, which dissolves erroneously formed microtubule-kinetochor attachments such as syntelic (both sister kinetochors are attached to one spindle pole) or merotelic (one kinetochor is attached to two spindle poles) attachments [Watanabe Y, Cold Spring Harb. Symp. Quant. Biol. 75, 419, 2010]. Recent data suggest that the phosphorylation of histone H2A at Thr 121 by Bub1 kinase is sufficient to localize AuroraB kinase to fulfill the attachment error correction checkpoint [Ricke et al. J. Cell Biol. 199, 931-949, 2012].

Incomplete mitotic checkpoint function has been linked with aneuploidy and tumourigenesis [Weaver B A and Cleveland D W, Cancer Res. 67, 10103, 2007; King R W, Biochim Biophys Acta 1786, 4, 2008]. In contrast, complete inhibition of the mitotic checkpoint has been recognised to result in severe chromosome missegregation and induction of apoptosis in tumour cells [Kops G J et al., Nature Rev. Cancer 5, 773, 2005; Schmidt M and Medema R H, Cell Cycle 5, 159, 2006; Schmidt M and Bastians H, Drug Res. Updates 10, 162, 2007]. Thus, mitotic checkpoint abrogation through pharmacological inhibition of components of the mitotic checkpoint, such as Bub1 kinase, represents a new approach for the treatment of proliferative disorders, including solid tumours such as carcinomas, sarcomas, leukaemias and lymphoid malignancies or other disorders, associated with uncontrolled cellular proliferation.

The present invention relates to chemical compounds that inhibit Bub1 kinase.

Established anti-mitotic drugs such as vinca alkaloids, taxanes or epothilones activate the mitotic checkpoint, inducing a mitotic arrest either by stabilising or destabilising microtubule dynamics. This arrest prevents separation of the duplicated chromosomes to form the two daughter cells. Prolonged arrest in mitosis forces a cell either into mitotic exit without cytokinesis (mitotic slippage or adaption) or into mitotic catastrophe leading to cell death [Rieder C L and Maiato H, Dev. Cell 7, 637, 2004]. In contrast, inhibitors of Bub1 prevent the establishment and/or functionality of the mitotic checkpoint and interfere with spindle attachment error correction, which finally results in severe chromosomal missegregation, induction of apoptosis and cell death.

These findings suggest that Bub1 inhibitors should be of therapeutic value for the treatment of proliferative disorders associated with enhanced uncontrolled proliferative cellular processes such as, for example, cancer, inflammation, arthritis, viral diseases, cardiovascular diseases, or fungal diseases in a warm-blooded animal such as man. WO 2013/050438, WO 2013/092512, WO 2013/167698, WO 2014/147203, WO 2014/147204, WO2014202590, WO2014202588, WO2014202584, WO2014202583 WO2015/063003, disclose substituted indazoles, substituted pyrazoles, and substituted cycloalkylpyrazoles, which are Bub1 kinase inhibitors.

In SciFinder® 5,6,7,8-tetrahydro-9H-pyrrolo[3,2-b:5,4-c′]dipyridin-9-one is disclosed as a commercially available compound, but no reference is given.

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Due to the fact that especially cancer disease as being expressed by uncontrolled proliferative cellular processes in tissues of different organs of the human- or animal body still is not considered to be a controlled disease in that sufficient drug therapies already exist, there is a strong need to provide further new therapeutically useful drugs, preferably inhibiting new targets and providing new therapeutic options (e.g. drugs with improved pharmacological properties).

DESCRIPTION OF THE INVENTION

Therefore, inhibitors of Bub1 represent valuable compounds that should complement therapeutic options either as single agents or in combination with other drugs.

In accordance with a first aspect, the invention relates to a compound of formula (I),

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in which:

A represents a group selected from:

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- wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted, one, two or three times, independently from each other, with R^3c;

E represents a group selected from:

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

Q represents O or N—OH;

X represents CR^4aor N;

Y represents CR^4bor N,
- wherein when X represents N, Y represents CR^4b, and when Y represents N, X represents CR^4a,

Z represents O, S, SO or NR²;

R¹represents hydrogen, C₁-C₄-alkyl or C₁-C₄-alkoxy-C₂-C₄-alkyl-;

R²represents hydrogen, C₁-C₄-alkyl, C₃-C₆-cycloalkyl, R^8a—C(O)—, R^8b—C(O)—, R^8c—C(O)—, R⁶R⁷N—C(O)—, R¹⁰R¹¹N—SO₂—, R⁹SO₂—, phenyl-C₁-C₃-alkyl or heteroaryl-C₁-C₃-alkyl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a;
- wherein C₁-C₄-alkyl and C₃-C₆-cycloalkyl are optionally substituted, one, two or three times, independently from each other, with R^3bor once with a group

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

R^3a, R^3b, R^3c, R^3drepresent, independently from each other, hydroxy, halogen, cyano, R¹⁰R¹¹N—, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl, C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy;

R^4a, R^4brepresent hydrogen, halogen, hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, R¹⁰R¹¹N—, R^8a—C(O)—NH—, R^8bO—C(O)—NH— or R¹⁰R¹¹N—C(O)—NH—;
- wherein C₁-C₄-alkyl is optionally substituted, one, two or three times, independently from each other, with R^3b;
- wherein C₁-C₄-alkoxy is optionally substituted, one, two or three times, independently from each other, with R^3d;

R⁵represents, independently from each other, halogen, hydroxy, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, R^12aR^12bN—, R^8a—C(O)—NH—, R^8bO—C(O)—NH— or R^12aR^12bN—C(O)—NH—;

R⁶, R⁷represent, independently from each other, hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₁-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkoxy-C₂-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkyl-S—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO₂—C₁-C₄-alkyl-, 4- to 7-membered heterocycloalkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a;
- wherein C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₁-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkoxy-C₂-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkyl-S—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO₂—C₁-C₄-alkyl- and 4- to 7-membered heterocycloalkyl, are optionally substituted, one, two or three times, independently from each other, with R^3b; or

R⁶and R⁷together with the nitrogen atom to which they are attached form a 4- to 7-membered nitrogen containing heterocyclic ring, optionally containing one or two additional heteroatom containing groups selected from O, S, C(═O) or NR^12a, and which may be optionally substituted, one, two or three times, independently from each other, with R^3a;

R^8arepresents, independently from each other, C₁-C₆-alkyl, C₁-C₄-alkoxy-C₁-C₄-alkyl-, C₁-C₄-alkyl-S—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO₂—C₁-C₄-alkyl-, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a; and
- wherein C₁-C₆-alkyl, C₁-C₄-alkoxy-C₁-C₄-alkyl-, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, are optionally substituted, one, two or three times, independently from each other, with R^3b;

R^8brepresents, independently from each other, C₁-C₆-alkyl, C₁-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkyl-S—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO₂—C₁-C₄-alkyl-, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a; and
- wherein C₁-C₆-alkyl, C₁-C₄-alkoxy-C₁-C₄-alkyl-, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, are optionally substituted, one, two or three times, independently from each other, with R^3b;

R^8crepresents C₁-C₄-alkyl;

R⁹represents, independently from each other, C₁-C₄-alkyl, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, 4- to 7-membered heterocycloalkyl-C₁-C₄-alkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a; and
- wherein C₁-C₄-alkyl, C₃-C₆-cycloalkyl and 4- to 7-membered heterocycloalkyl-C₁-C₄-alkyl groups are optionally substituted, one, two or three times, independently from each other, with R^3b;

R¹⁰, R¹¹represent, independently from each other, hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, R^12a—O—C(O)— or phenyl,
- wherein said C₁-C₆-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃—C-cycloalkyl or R^12aR^12bN—,
- wherein said phenyl group is optionally substituted, one or more times, independently from each other, with with halogen, hydroxy, C₁-C₃-alkyl, C₁-C₃-alkoxy or C₁-C₃-haloalkoxy;
- or,

R¹⁰and R¹¹together with the nitrogen atom to which they are attached form a 4- to 7-membered nitrogen containing heterocyclic ring, optionally containing one additional heteroatom selected from O, NR^12aand S, and which may be optionally substituted, one or more times, independently from each other, with halogen or C₁-C₃-alkyl;

R^12a, R^12brepresent, independently from each other, hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl or —C(═O)—(C₁-C₆-alkyl);

m represents 0, 1 or 2;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In a second aspect, the invention relates to compounds of formula (I) as described supra, wherein:

A represents a group selected from:

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- wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted, one, two or three times, independently from each other, with R^3c;

E represents a group:

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

Q represents O or N—OH;

X represents CR^4a;

Y represents CR^4bor N,

Z represents O, S, SO or NR²;

R¹represents hydrogen or C₁-C₄-alkyl;

R²represents hydrogen, C₁-C₄-alkyl, C₃-C₆-cycloalkyl, R^8a—C(O)—, R^8bO—C(O)—, R^8cS—C(O)—, R⁶R⁷N—C(O)—, R¹⁰R¹¹N—SO₂—, R⁹SO₂—, phenyl-C₁-C₃-alkyl or heteroaryl-C₁-C₃-alkyl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a;
- wherein C₁-C₄-alkyl and C₃-C₆-cycloalkyl are optionally substituted, one, two or three times, independently from each other, with R^3bor once with a group

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

R^3arepresents, independently from each other, halogen, R¹⁰R¹¹N—, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl;

R^3brepresents, independently from each other, hydroxy, halogen, cyano, R¹⁰R¹¹N—, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl;

R^3crepresents, independently from each other, hydroxy, halogen, cyano, R¹⁰R¹¹N—, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl, C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy;

R^3drepresents, independently from each other, halogen, R¹⁰R¹¹N—, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl;

R^4arepresents hydrogen, halogen, hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, R¹⁰R¹¹N—, R^8a—C(O)—NH—, R^8bO—C(O)—NH— or R¹⁰R¹¹N—C(O)—NH—;

R^4brepresents hydrogen, halogen, hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, R¹⁰R¹¹N—, R^8a—C(O)—NH—, R^8bO—C(O)—NH— or R¹⁰R¹¹N—C(O)—NH—;
- wherein C₁-C₄-alkyl is optionally substituted, one, two or three times, independently from each other, with R^3b;
- wherein C₁-C₄-alkoxy is optionally substituted, one, two or three times, independently from each other, with R^3d;

R⁵represents, independently from each other, halogen, hydroxy, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, R^12aR^12bN—, R^8a—C(O)—NH—, R^8bO—C(O)—NH— or R^12aR^12bN—C(O)—NH—;

R⁶, R⁷represent, independently from each other, hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₁-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkoxy-C₂-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkyl-S—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO₂—C₁-C₄-alkyl-, 4- to 7-membered heterocycloalkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a;
- wherein C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₁-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkoxy-C₂-C₄-alkoxy-C₂-C₄-alkyl-, C₁-C₄-alkyl-S—C₁-C₄-alkyl-S—C₁-C₄-alkyl-, C₁-C₄—SO—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO₂—C₁-C₄-alkyl- and 4- to 7-membered heterocycloalkyl, are optionally substituted, one, two or three times, independently from each other, with R^3b; or

R⁶and R⁷together with the nitrogen atom to which they are attached form a 4- to 6-membered nitrogen containing heterocyclic ring, optionally containing one or two additional heteroatom containing groups selected from O, S, C(═O) or NR^12a, and which may be optionally substituted, one, two or three times, independently from each other, with R^3a;

R^8arepresents, independently from each other, C₁-C₆-alkyl, C₁-C₄-alkoxy-C₁-C₄-alkyl-, C₁-C₄-alkyl-S—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO—C₁-C₄-alkyl-, C₁-C₄-alkyl-SO₂—C₁-C₄-alkyl-, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a; and
- wherein C₁-C₆-alkyl, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, are optionally substituted, one, two or three times, independently from each other, with R^3b;

R^8brepresents, independently from each other, C₁-C₆-alkyl, C₁-C₄-alkoxy-C₂-C₄-alkyl-, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a; and
- wherein C₁-C₆-alkyl is optionally substituted, one, two or three times, independently from each other, with R^3b;

R^8crepresents C₁-C₄-alkyl;

R⁹represents, independently from each other, C₁-C₄-alkyl, C₃-C₆-cycloalkyl, 4- to 7-membered heterocycloalkyl, 4- to 7-membered heterocycloalkyl-C₁-C₄-alkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with R^3a; and
- wherein C₁-C₄-alkyl and C₃-C₆-cycloalkyl are optionally substituted, one, two or three times, independently from each other, with R^3b;

R¹⁰, R¹¹represent, independently from each other, hydrogen, C₁-C₃-alkyl, C₃-C₄-cycloalkyl, R^12a—O—C(O)— or phenyl,

R^12a, R^12brepresent, independently from each other, hydrogen, C₁-C₃-alkyl;

m represents 0 or 1;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In a third aspect, the invention relates to compounds of formula (I) as described supra, wherein:

A represents a group selected from:

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- wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted one time with R^3c;

E represents a group:

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

Q represents O or N—OH;

X represents CR^4a;

Y represents CR^4bor N,

Z represents O, S, SO or NR²;

R¹represents hydrogen or C₁-C₄-alkyl;

R²represents hydrogen, C₁-C₄-alkyl, R^8a—C(O)—, R^8bO—C(O)—, R^8c—C(O)—, R⁶R⁷N—C(O)—, R¹⁰R¹¹N—SO₂—, R⁹SO₂— or phenyl-C₁-C₃-alkyl,
- wherein phenyl is optionally substituted, one, two or three times, independently from each other, with R^3a;
- wherein C₁-C₄-alkyl is optionally substituted, one, two or three times, independently from each other, with R^3bor once with a group

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

R^3arepresents, independently from each other, halogen, C₁-C₄-alkyl, C₁-C₄-alkoxy;

R^3brepresents, independently from each other, hydroxy, halogen, cyano, R¹⁰R¹¹N—, C₁-C₄-alkyl;

R^3crepresents, independently from each other, halogen, C₁-C₂-alkyl;

R^3drepresents, independently from each other, halogen, R¹⁰R¹¹N—, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl;

R^4arepresents hydrogen, C₁-C₄-alkyl, R¹⁰R¹¹N—, R^8a—C(O)—NH—, R^8bO—C(O)—NH— or R¹⁰R¹¹N—C(O)—NH—;

R^4brepresents hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-alkoxy;
- wherein C₁-C₄-alkyl is optionally substituted, one, two or three times, independently from each other, with R^3b,
- wherein C₁-C₄-alkoxy is optionally substituted, one, two or three times, independently from each other, with R^3d;

R⁶, R⁷represent, independently from each other, hydrogen, C₁-C₄-alkyl, C₃-C₄-cycloalkyl, methoxy-ethyl-, methoxy-ethoxy-ethyl-, methylsulfanyl-ethyl-, methylsulfinyl-ethyl-, methylsulfonyl-ethyl-, 5- to 6-membered heterocycloalkyl, or heteroaryl;
- wherein C₁-C₄-alkyl is optionally substituted, one, two or three times, independently from each other, with halogen; or

R⁶and R⁷together with the nitrogen atom to which they are attached form a 5- to 6-membered nitrogen containing heterocyclic ring, optionally containing one or two additional heteroatom containing group selected from O, C(═O) or NR^12a, and which may be optionally substituted, one or two times, independently from each other, with R^3a;

R^8arepresents, independently from each other, C₁-C₆-alkyl, C₁-alkoxy-C₁-C₂-alkyl-, methylsulfanyl-C₁-C₂-alkyl-, methylsufinyl-C₁-C₂-alkyl-, methylsulfonyl-C₁-C₂-alkyl-, C₃-C₄-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with halogen, methyl or methoxy; and
- wherein C₁-C₆-alkyl, cyclopropyl and 4- to 6-membered heterocycloalkyl, are optionally substituted, one, two or three times, independently from each other, with R^3b;

R^8brepresents, independently from each other, C₁-C₅-alkyl,
- wherein C₁-C₅-alkyl is optionally substituted, one, two or three times, independently from each other, with halogen or methoxy;

R^8crepresents C₁-C₄-alkyl;

R⁹represents, independently from each other, C₁-C₃-alkyl, C₃-C₄-cycloalkyl, 4- to 6-membered heterocycloalkyl, 4- to 6-membered heterocycloalkyl-C₁-C₂-alkyl-, or heteroaryl,
- wherein heteroaryl is optionally substituted, one, two or three time, with R^3a; and
- wherein C₁-C₃-alkyl is optionally substituted, one, two or three times, independently from each other, with hydroxy or fluoro;

R¹⁰, R¹¹represent, independently from each other, hydrogen, C₁-C₃-alkyl, C₃-C₄-cycloalkyl,

R^12arepresents hydrogen, or C₁-C₂-alkyl;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In a fourth aspect, the invention relates to compounds of formula (I) as described supra, wherein:

A represents a group selected from:

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- wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted once with R^3c;

E represents a group:

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

Q represents O or N—OH;

X represents CR^4a;

Y represents CR^4bor N,

Z represents O, S, SO or NR²;

R¹represents hydrogen or C₁-C₄-alkyl;

R²represents hydrogen, C₁-C₄-alkyl, R^8a—C(O)—, R^8bO—C(O)—, R^8cS—C(O)—, R⁶R⁷N—C(O)—, R¹⁰R¹¹N—SO₂—, R⁹SO₂— or phenyl-C₁-C₃-alkyl,
- wherein phenyl is optionally substituted, one, two or three times, independently from each other, with R^3a;
- wherein C₁-C₄-alkyl is optionally substituted, one, two or three times, independently from each other, with R^3bor one time with a group

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

R^3arepresents, independently from each other, halogen, C₁-C₄-alkyl, C₁-C₄-alkoxy;

R^3brepresents, independently from each other, hydroxy, halogen, cyano, C₁-C₄-alkyl;

R^3crepresents, independently from each other, halogen, C₁-C₂-alkyl;

R^3drepresents, independently from each other, halogen, (CH₃)₂N—, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl;

R^4arepresents hydrogen, C₁-C₄-alkyl, H₂N—, R^8a—C(O)—NH—, R^8bO—C(O)—NH— or R¹⁰R¹¹N—C(O)—NH—;

R^4brepresents hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-alkoxy;
- wherein C₁-C₄-alkoxy is optionally substituted, one, two or three times, independently from each other, with R^3d;

R⁶, R⁷represent, independently from each other, hydrogen, C₁-C₄-alkyl, cyclopropyl, methoxy-ethyl-, methoxy-ethoxy-ethyl-, methylsulfanyl-ethyl-, methylsulfinyl-ethyl-, methylsulfonyl-ethyl-, tetrahydro-2H-pyran-4-yl or pyridyl;
- wherein C₁-C₄-alkyl is optionally substituted, one, two or three times, independently from each other, with halogen; or

R⁶and R⁷together with the nitrogen atom to which they are attached form a 5- to 6-membered nitrogen containing heterocyclic ring, optionally containing one or two additional heteroatom containing group selected from O, C(═O) or NR^12a, and which may be optionally substituted, one or two times, independently from each other, with methyl;

R^8arepresents, independently from each other, C₁-C₆-alkyl, methoxymethyl-, methylsulfanyl-C₁-C₂-alkyl-, methylsulfinyl-C₁-C₂-alkyl-, methylsulfonyl-C₁-C₂-alkyl-, cyclopropyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl,
- wherein phenyl and heteroaryl are optionally substituted, one, two or three times, independently from each other, with fluoro, methyl or methoxy; and
- wherein C₁-C₆-alkyl, cyclopropyl and 4- to 6-membered heterocycloalkyl, are optionally substituted, one, two or three times, independently from each other, with hydroxy, fluoro, methyl or (CH₃)₂N—;

R^8brepresents, independently from each other, C₁-C₅-alkyl,
- wherein C₁-C₅-alkyl is optionally substituted, one, two or three times, independently from each other, with fluoro or methoxy;

R^8crepresents C₁-C₄-alkyl;

R⁹represents, independently from each other, C₁-C₃-alkyl, cyclopropyl, 4 to 6 membered heterocycloalkyl, 4 to 6 membered heterocycloalkyl-C₁-C₂-alkyl-, or heteroaryl,
- wherein heteroaryl is optionally substituted, one time with methyl; and
- wherein C₁-C₃-alkyl is optionally substituted, one, two or three times, independently from each other, with hydroxy or fluoro;

R¹⁰, R¹¹represent, independently from each other, hydrogen, C₁-C₃-alkyl, C₃-C₄-cycloalkyl,

R^12arepresents hydrogen, or C₁-C₂-alkyl;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In a fifth aspect, the invention relates to compounds of formula (I) as described supra, wherein:

A represents a group selected from:

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

E represents a group:

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- wherein * indicates the point of attachment of said group with the rest of the molecule;

Q represents O;

X represents CR^4a;

Y represents CR^4bor N;

Z represents O, S, or NR²;

R¹represents hydrogen;

R²represents hydrogen, cyano-CH₂—, R^8a—C(O)—, R^8bO—C(O)—, R^8cS—C(O)—, R⁶R⁷N—C(O)—, (CH₃)HN—SO₂—, (CH₃)₂N—SO₂—, R⁹SO₂— or phenyl-CH₂—;

R^3crepresents fluoro;

R^3drepresents, independently from each other, (CH₃)₂N—, methoxy or cyclopropyl;

R^4arepresents hydrogen, methyl, H₂N—, R^8a—C(O)—NH—, R^8bO—C(O)—NH— or R¹⁰R¹¹N—C(O)—NH—;

R^4brepresents hydrogen, fluoro, chloro, bromo, methoxy or ethoxy,
- wherein methoxy and ethoxy are optionally substituted, one, two or three times with fluoro or one time with R^3d;

R⁶, R⁷represent, independently from each other, hydrogen, C₁-C₄-alkyl, cyclopropyl, methoxy-ethyl, methoxy-ethoxy-ethyl, methylsulfanyl-ethyl, methylsulfinyl-ethyl, methylsulfonyl-ethyl, tetrahydro-2H-pyran-4-yl or pyridyl,
- wherein C₁-C₄-alkyl is optionally substituted, one or two times with fluoro; or

R⁶and R⁷together with the nitrogen atom to which they are attached form a 5- to 6-membered nitrogen containing heterocyclic ring, optionally containing one or two additional heteroatom containing group selected from O, C(═O) or NR^12a;

R^8arepresents, independently from each other, C₁-C₆-alkyl, methoxymethyl, methylsulfanyl-C₁-C₂-alkyl, methylsulfinyl-ethyl, methylsulfonyl-ethyl, cyclopropyl, phenyl, pyridyl, 1H-imidazolyl, 1-methyl-1H-imidazolyl, 1H-pyrazolyl, 1H-1,2,3-triazolyl,
- 1,2-thiazolyl, 1,3-thiazolyl or 1,3-oxazolyl,
- wherein phenyl is optionally substituted, one or two times, independently from each other, with fluoro, methyl or methoxy, and
- wherein C₁-C₆-alkyl and cyclopropyl, are optionally substituted, one, two or three times, independently from each other, with hydroxy or fluoro;

R^8brepresents, independently from each other, C₁-C₅-alkyl,
- wherein C₁-C₅-alkyl is optionally substituted, one time, with fluoro or methoxy;

R^8crepresents tert-butyl;

R⁹represents, independently from each other, C₁-C₃-alkyl, cyclopropyl, tetrahydro-2H-pyran-4-yl, tetrahydro-2H-pyran-4-ylmethyl, pyridyl, 1H-imidazolyl or 1-methyl-1H-imidazolyl, and
- wherein C₁-C₃-alkyl is optionally substituted one time with hydroxy or one, two or three times with fluoro;

R^12arepresents hydrogen, or C₁-alkyl;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In accordance with another aspect, the invention relates to a compound of formula (I), which is selected from the group consisting of:

6-benzyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-(3-chloropyridin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
tert-butyl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
3-(phenylamino)-2-(pyridin-4-yl)-1,7-dihydrothiopyrano[3,4-b]pyrrol-4(5H)-one,
6-(cycopropylcarbonyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
6-acetyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-6-propanoyl-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(2,2-dimethylpropanoyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
N-ethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide
tert-butyl 2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-butyl 2-(2-methylpyrimidin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrolo[2,3-c]pyridine-6-carboxylate,
tert-butyl 2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-(2-methylpyrimidin-4-yl)-3-(phenylamino)-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
2-(2-methylpyrimidin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(2-methylpropanoyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
methyl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
6-(methylsulfonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-1,7-dihydrothiopyrano[3,4-b]pyrrol-4(5H)-one 6-oxide,
2-(2-aminopyridin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-(2-aminopyridin-4-yl)-3-(phenylamino)-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
tert-butyl 2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-ethyl-2-(2-methylpyrimidin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
6-acetyl-2-(2-methylpyrimidin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
methyl 2-(2-methylpyridin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-[2-(acetylamino)pyridin-4-yl]-N-ethyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
2-(2-methylpyrimidin-4-yl)-6-(methylsulfonyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
N-4-[6-(cyclopropylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
methyl 2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrolo[2,3-c]pyridine-6-carboxylate,
N-4-[6-(methyisulfonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
2-(3-fluoropyridin-4-yl)-3-(phenylamino)-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylacetamide,
N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylcyclopropanecarboxamide,
3,3,3-trifluoro-N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylpropanamide,
2-(3-methylpyridin-4-yl)-3-(phenylamino)-1,7-dihydrothiopyrano[3,4-b]pyrrol-4(5H)-one,
2-(3-chloropyridin-4-yl)-3-(phenylamino)-1,7-dihydrothiopyrano[3,4-b]pyrrol-4(5H)-one,
2-(3-methoxypyridin-4-yl)-3-(phenylamino)-1,7-dihydrothiopyrano[3,4-b]pyrrol-4(5H)-one,
2-(3-methylpyridin-4-yl)-3-(phenylamino)-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
2-(3-bromopyridin-4-yl)-3-(phenylamino)-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
2-(3-chloropyridin-4-yl)-3-(phenylamino)-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
2-(3-methoxypyridin-4-yl)-3-(phenylamino)-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylpropanamide,
2-methoxy-N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylacetamide,
2-(methylsulfanyl)-N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylacetamide,
2-(methylsufinyl)-N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylacetamide,
2-(methylsulfonyl)-N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylacetamide,
N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-yl-1,3-thiazole-4-carboxamide,
N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-yl-1,3-oxazole-5-carboxamide,
N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-yl-1,3-thiazole-5-carboxamide,
4-fluoro-N-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylbenzamide,
methyl 4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylcarbamate,
1-ethyl-3-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylurea,
1-cyclopropyl-3-4-[4-oxo-3-(phenylamino)-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl]pyridin-2-ylurea,
6-(3-hydroxypropanoyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(3-hydroxy-3-methylbutanoyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(3,3-dimethylbutanoyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(1H-imidazol-5-ylcarbonyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-[(1-methyl-1H-imidazol-4-yl)carbonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-6-(pyridin-2-ylcarbonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-6-(pyridin-3-ylcarbonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-6-(pyridin-4-ylcarbonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
1-methyl-6-(methylsulfonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
1-ethyl-6-(methylsulfonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(cyclopropylsulfonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-6-(propan-2-ylsulfonyl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-[(difluoromethyl)sulfonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-6-[(3,3,3-trifluoropropyl)sulfonyl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-6-(tetrahydro-2H-pyran-4-ylsulfonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-6-[(tetrahydro-2H-pyran-4-ylmethyl)sulfonyl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(1H-imidazol-5-ylsulfonyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-6-(pyridin-2-ylsulfonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-2-(pyridin-4-yl)-6-(pyridin-3-ylsulfonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
ethyl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
propan-2-yl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2,2-dimethylpropyl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-fluoroethyl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-methoxyethyl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate
N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-(2,2-difluoroethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-cyclopropyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-tert-butyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-(2-methoxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-[2-(methylsulfanyl)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-2-[(S)-methylsulfinyl]ethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-[2-(methylsulfonyl)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-[2-(2-methoxyethoxy)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
6-[(2-oxoimidazolidin-1-yl)carbonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-phenylamino)-2-(pyridin-4-yl)-6-(pyrrolidin-1-ylcarbonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-(phenylamino)-6-(piperidin-1-ylcarbonyl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(morpholin-4-ylcarbonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-[(4-methylpiperazin-1-yl)carbonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(tetrahydro-2H-pyran-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
4-oxo-3-(phenylamino)-N-(pyridin-3-yl)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
[4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridin-6-yl]acetonitrile,
tert-butyl 2-(3-methylpyridin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrolo[2,3-c]pyridine-6-carboxylate,
tert-butyl 2-(3-bromopyridin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-(3-fluoropyridin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
tert-butyl 2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-(3-methoxypyridin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
methyl 2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrolo[2,3-c]pyridine-6-carboxylate,
6-acetyl-2-(3-methoxypyridin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(2,2-dimethylpropanoyl)-2-(3-methoxypyridin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-(3-methoxypyridin-4-yl)-6-(methylsulfonyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(cyclopropylcarbonyl)-2-(3-methoxypyridin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-(3-methoxypyridin-4-yl)-3-(phenylamino)-6-(propan-2-ylsulfonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-[(difluoromethyl)sulfonyl]-2-(3-methoxypyridin-4-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-(3-methoxypyridin-4-yl)-3-(phenylamino)-6-[(3,3,3-trifluoropropyl)sulfonyl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
N-4-[6-acetyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-4-[6-(1H-imidazol-5-ylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-4-[4-oxo-3(phenylamino)(pyridin-2-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-4-[4-oxo-3-(phenylamino)-6-(pyridin-3-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-4-[4-oxo-3-(phenylamino)-1-(pyridin-4-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-4-[6-(1H-imidazol-5-ylsulfonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-(4-6-[(1-methyl-1H-imidazol-4-yl)carbonyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-ylpyridin-2-yl)acetamide,
tert-butyl 2-2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-butyl 2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-butyl 2-[2-([(1S)-2,2-difluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-butyl 4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
6-[2-hydroxyethyl)sulfonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-[2-(acetylamino)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-{4-[3-anilino-6-(morpholinylcarbonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-4-[4-oxo-3-(phenylamino)-6-(pyrrolidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-(4-{3-anilino-6-[(4-methylpiperazin-1-yl)carbonyl]-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl}pyridin-2-yl)acetamide,
tert-butyl 2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-Butyl 3-anilino-2-[2-({[(rel-1S,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate
2-fluoro-2-methyl-N-4-[4-oxo-3-(phenylamino-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl propanamide,
tert-butyl 2-(2-[(1-fluorocyclopropyl)carbonyl]aminopyridin-4-yl)-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
1-fluoro-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ycyclopropanecarboxamide,
4-fluoro-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-1,3-thiazole-5-carboxamide,
(1S,2S)-2-fluoro-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
(I S)-2,2-difluoro-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
(1S,2S)-2-fluoro-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
methyl 2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-[4-(3-anilino-4-oxo-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl)pyridin-2-yl]-4-fluoro-3-methoxybenzamide,
methyl 3-anilino-2-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
(1S,2R)—N-[4-(3-Anilino-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl]-2-fluorocyclopropanecarboxamide,
methyl 3-anilino-2-[2-({[(1S,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
methyl 3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-[4-(3-anilino-4-oxo-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl)pyridin-2-yl]-1H-pyrazole-5-carboxamide
methyl 3-anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
methyl 3-anilino-2-(2-{[(1-fluorocyclopropyl)carbonyl]amino}pyridin-4-yl)-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
rel-(1R,2R)—N-{4-[3-anilino-6-(methylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide,
(1RS)—N-{4-[3-anilino-6-(methylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-2,2-difluorocyclopropanecarboxamide,
N-{4-[3-anilino-6-(methylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-1-fluorocyclopropanecarboxamide,
N-{4-[3-anilino-6-(methylsulfonyl)oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-1,3-thiazole-5-carboxamide,
N-[4-(3-anilino-4-oxo-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl)pyridin-2-yl]-2-hydroxy-2-methylpropanamide,
N-[4-(3-anilino-4-oxo-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl)pyridin-2-yl]-N2,N2-dimethylglycinamide,
N-[4-(3-Anilino-4-oxo-1,4,5,7-tetrahydropyrano[3,4-b]pyrrol-2-yl)pyridin-2-yl]-3,4-difluorobenzamide,
isopropyl 3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
isopropyl 3-anilino-4-oxo-2-{2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl}-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
isopropyl 3-anilino-2-[2-({[rel-(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
isopropyl 3-anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
isopropyl 3-anilino-2-(2-{[(1-fluorocyclopropyl)carbonyl]amino}pyridin-4-yl)-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-{4-[3-anilino-6-(1H-imidazol-5-ylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-4-fluorobenzamide,
N-{4-[3-anilino-6-(1H-imidazol-5-ylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-1,3-thiazole-5-carboxamide,
N-{4-[3-anilino-6-(1H-imidazol-5-ylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-2-fluoro-2-methylpropanamide,
rel-(1R,2R)—N-{4-[3-anilino-6-(1H-imidazol-5-ylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide,
(1RS)—N-{4-[3-anilino-6-(1H-imidazol-5-ylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3c]pyridin-2-yl]pyridin-2-yl}-2,2-difluorocyclopropanecarboxamide,
N-{4-[3-anilino-6-(1H-imidazol-5-ylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}-1-fluorocyclopropanecarboxamide,
N-{4-[3-anilino-4-oxo-6-(piperidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
2-(2-acetamidopyridin-4-yl)-3-anilino-N,N-diethyl-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
2-(2-acetamidopyridin-4-yl)-3-anilino-N-methyl-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-{4-[3-anilino-4-oxo-6-(3,3,3-trifluoropropanoyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-[4-(3-anilino-6-isobutyryl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl]acetamide,
N-{4-[3-anilino-6-(isopropylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-{4-[3-anilino-6-(cyclopropylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide
N-{4-[3-anilino-4-oxo-6-(tetrahydro-2H-pyran-4-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide
N-{4-[3-anilino-6-(3,3-dimethylbutanoyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-{4-[3-anilino-4-oxo-6-(1,3-thiazol-5-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-{4-[3-anilino-6-(1,3-oxazol-5-ylcarbonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-{4-[3-anilino-6-(3-hydroxy-3-methylbutanoyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-(4-{3-anilino-4-oxo-[(2RS)-3,3,3-trifluoro-2-methylpropanoyl]-4,5,6,7-tetrahydro-1H-Pyrrolo[2,3-c]Pyridin-2-yl)pyridin-2-yl}acetamide,
N-{4-[3-anilino-6-(4,4-dimethylpentanoyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-[4-(3-anilino-4-oxo-6-propanoyl-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl]acetamide,
N-{4-[3-anilino-6-(2,2-dimethylpropanoyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-(4-{3-anilino-4-oxo-6-[(3,3,3-trifluoropropyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl}pyridin-2-yl)acetamide,
ethyl 2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-fluoroethyl 2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
isopropyl 2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-(2-acetamidopyridin-4-yl)-3-anilino-N-isopropyl-N-methyl-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
2-(2-acetamidopyridin-4-yl)-3-anilino-N-methyl-4-oxo-N-propy-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide
N-(4-{3-anilino-6-[(2-hydroxyethyl)sulfonyl]-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl}pyridin-2-yl)acetamide
N-{4-[3-anilino-6-(3-hydroxypropanoyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-{4-[3-anilino-4-oxo-6-(4,4,4-trifluorobutanol)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-(4-{3-anilino-6-[(1-methylpiperidin-4-yl)carbonyl]-4-oxo-4,5,6,7-tetrahydro-1H-Pyrrolo[2,3-c]Pyridin-2-yl}pyridin-2-yl)acetamide,
N-(4-{3-anilino-6-[3-(methylsulfanyl)propanoyl]-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]Pyridin-2-yl}pyridin-2-yl)acetamide,
N-{4-[3-anilino-4-oxo-6-(1,2-thiazol-4-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-{4-[3-anilino-4-oxo-6-(1,3-thiazol-4-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
N-{4-[3-anilino-6-(1,3-oxazol-4-ylcarbonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
tert-butyl 3-anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
(1S,2S)—N-[4-(3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl]-2-fluorocyclopropanecarboxamide,
(1S,2S)-2-fluoro-N-4-[4-oxo-3(phenylamino)-6-propanoyl-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
N-4-[6-(1,3-oxazol-2-ylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
(1S,2S)-2-fluoro-N-4-[4-oxo-3-(phenylamino)-6-(pyridin-4-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
(1S,2S)-2-fluoro-N-4-[6-(3-hydroxy-3-methylbutanoyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
(1S,2S)-2-fluoro-N-4-[6-(3-hydroxypropanoyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide
(1S,2S)-2-fluoro-N-4-[6-(methylsulfonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
(1S,2S)-2-fluoro-N-4-[6-(1H-imidazol-5-ylsulfonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
methyl 2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-N-methyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-ethyl-2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
(1S,2S)-2-fluoro-N-(4-6-[(4-methylpiperazin-1-yl)carbonyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-ylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-6-[3-(methylsulfonyl)propanoyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-ylpyridin-2-yl)acetamide,
N-4-[6-(3-fluoropropanoyl)-4 oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
(1S,2S)—N-4-[6-(cyclopropylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-2-fluorocyclopropanecarboxamide,
(1S,2S)—N-4-[6-(2,2-dimethylpropanoyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl)-2-fluorocyclopropanecarboxamide,
(1S,2S)-2-fluor-N-4-[4-oxo(phenylamino)-6-propan-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylcyclopropanecarboxamide,
ethyl 2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
propan-2-yl 2-[2-([(1S,2S)-2-fluorocylopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N,N-diethyl-2-[2-([(1S,2S)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
(1E/Z)—N′-hydroxy-2-[(4E/Z)-4-(hydroxyimino-3-(phenylamino)-2-(pyridin-4-yl)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridin-6-yl]ethanimidamide,
N-{4-[3-Anilino-4-oxo-6-(4,4,4-trifluoro-3,3-dimethylbutanoyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide,
tert-Butyl 3-anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-Butyl 3-anilino-4-oxo-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-Butyl 3-anilino-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrolo[2,3-c]pyridine-6-carboxylate,
tert-Butyl 3-anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrolo[2,3-c]pyridine-6-carboxylate,
3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-Anilino-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-Anilino-2-[3-(2-methoxyethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-Anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-Acetyl-3-anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-Acetyl-3-(phenylamino)-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-Acetyl-2-[3-(2-methoxyethoxy)pyridin-4-yl]-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-Acetyl-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-6-(methylsulfonyl)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-(Methylsulfonyl)-3-(phenylamino)-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-[3-(2-Methoxyethoxy)pyridin-4-yl]-6-(methylsulfonyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-[3-(Cyclopropylmethoxy)pyridin-4-yl]-6-(methylsulfonyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one
Methyl 2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrol[2,3-c]pyridine-6-carboxylate
2-[3-(2,2-Difluoroethoxy)pyridin-4-yl]-N-methyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide
2-[3-(2,2-Difluoroethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide
2-[3-(2,2-Difluoroethoxy)pyridin-4-yl]-6-(morpholin-4-ylcarbonyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one
2-[3-(2,2-Difluoroethoxy)pyridin-4-yl]-6-[(4-methylpiperazin-1-yl)carbonyl]-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one
2-[3-(2,2-Difluoroethoxy)pyridin-4-yl]-3-(phenylamino)-6-(propan-2-ylsulfonyl-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one
Methyl 4-oxo-3-(phenylamino)-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate
N-Methyl-4-oxo-3-(phenylamino)-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide
N,N-Dimethyl-4-oxo-3-(phenylamino)-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide
6-(Morpholin-4-ylcarbonyl)-3-(phenylamino)-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one
6-[(4-Methylpiperazin-1-yl)carbonyl]-3-(phenylamino)-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one
3-(Phenylamino)-6-(propan-2-ylsulfonyl)-2-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one
Methyl 2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate
2-[3-(2-Methoxyethoxy)pyridin-4-yl]-N-methyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide
Methyl 2-[3-(cyclpropylmethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate
2-[3-(Cyclopropylmethoxy)pyridin-4-yl]-N-methyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide
2-[3-(Cyclpropylmethoxy)pyridin-4-yl]-6-[(4-methylpiperazin-1-yl)carbonyl]-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one
tert-Butyl 2-2-[(4-fluoro-3-methoxybenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-4-[6-(Dimethylsulfamoyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
N-4-[6-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]carbonyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylacetamide,
tert-Butyl 2-2-[(4-fluoro-3-methoxybenzoyl)amino]pyridin-4-yl-1-methyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
4-Fluoro-3-methoxy-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
N-4-[6-Acetyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-4-fluoro-3-methoxybenzamide,
N-4-[6-(Dimethysulfamoyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-4-fluoro-3-methoxybenzamide,
4-Fluoro-3-methoxy-N-4-[6-(morpholin-4-ylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
N-4-[6-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]carbonyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-4-fluoro-3-methoxybenzamide,
4-Fluoro-3-methoxy-N-4-[4-oxo-3-(phenylamino-6-(pyrrolidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
tert-Butyl 2-2-[(4-fluoro-2-methylbenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
4-Fluoro-2-methyl-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
N-4-[6-Acetyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-4-fluoro-2-methylbenzamide,
tert-Butyl 2-2-[(4-methoxy-2-methylbenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
4-Methoxy-2-methyl-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
tert-Butyl 2-2-[(5-fluoro-2-methylbenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
5-Fluoro-2-methyl-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
tert-Butyl 2-2-[(4-methoxybenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-4-[6-Acetyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-4-fluorobenzamide,
(1S,2S)—N-4-[6-(Dimethylsulfamoyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-2-fluorocyclopropanecarboxamide,
N-4-[6-(Dimethylsulfamoyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-1-fluorocyclopropanecarboxamide,
tert-Butyl 4-oxo-3-(phenylamino)-2-2-[(1H-1,2,3-azolylcarbonyl)amino]pyridin-4-yl-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-4-[4-Oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-1H-1,2,3-triazole-5-carboxamide,
tert-Butyl 2-3-[2-(dimethylamino)ethoxy]pyridin-4-yl-4-oxo-3-(phenylamino-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-3-[2-(Dimethylamino)ethoxyl]pyridin-4-yl-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
6-Acetyl-2-3-[2-(dimethylamino)ethoxy]pyridin-4-yl-3-(phenylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-c]pyridin-4-one,
2-3-[2-(Dimethylamino)ethoxy]pyridin-4-yl-N,N-dimethyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-sulfonamide,
2-[3-(2-Methoxyethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-sulfonylamide,
3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-sulfonamide,
2-[3-(Cyclopropylmethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-sulfonamide,
tert-Butyl 2-2-[(3-fluoro-4-methoxybenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
3-Fluoro-4-methoxy-N-4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
N-4-[6-Acetyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl)-3-fluoro-4-methoxybenzamide,
tert-Butyl 2-2-[(3-fluoro-4-methoxybenzoyl)amino]pyridin-4-yl)-1-methyl-4-oxo-3-(phenylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
3-Fluoro-4-methoxy-N-4-[1-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide
N-4-[6-Acetyl-1-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-3-fluoro-4-methoxybenzamide,
N-4-[6-(Dimethylsulfamoyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl)-3-fluoro-4-methoxybenzamide,
N-4-[6-(Dimethylsulfamoyl)-1-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl-3-fluoro-4-methoxybenzamide,
3-Fluoro-4-methoxy-N-4-[6-(morpholin-4-ylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
N-4-[6-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]carbonyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl)-3-fluoro-4-methoxybenzamide,
3-Fluoro-4-methoxy-N-4-[4-oxo-3-(phenylamino-6-(pyridin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-ylbenzamide,
tert-butyl 2-(2-Aminopyridin-4-yl)-3-[(4-methylphenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrolo[2,3-c]pyridine-6-carboxylate,
tert-Butyl 2-(2-acetamidopyridin-4-yl-3-[(4-methylphenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-Butyl 2-(2-aminopyridin-4-yl)-3-[(4-fluorophenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrol[2,3c]pyridine-6-carboxylate,
tert-Butyl 2-(2-acetamidopyridin-4-yl)-3-[(4-fluorophenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-Butyl 4-oxo-3(phenylamino)-2-[3-(trifluoromethyl)pyridin-4-yl]-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
3-(Phenylamino)-2-[3-(trifluoromethyl)pyridin-4-yl]-1,7-dihydrothiopyrano[3,4-b]pyrrol-4(5H)-one,
3-(Phenylamino)-2-[3-(trifluoromethyl)pyridin-4-yl]-1,7-dihydropyrano[3,4-b]pyrrol-4(5H)-one,
S-tert-butyl 2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carbothioate,
N-(4-{3-[(4-Fluorophenyl)amino]-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl}pyridin-2-yl)acetamide,
N-(4-{3-[(4-methylphenyl)amino]-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl}pyridin-2-yl)acetamide,
S-tert-butyl 3-anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carbothioate,
S-tert-butyl 3-anilino-2-{2-[(3-fluoro-4-methoxybenzoyl)amino]pyridin-4-yl}-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carbothioate,
S-tert-butyl 3-anilino-2-{2-[(4-fluoro-3-methoxybenzoyl)amino]pyridin-4-yl}-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carbothioate,
S-tert-butyl 3-anilino-2-(2-{[(1-fluorocyclopropyl)carbonyl]amino)pyridin-4-yl}-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carbothioate,
S-tert-butyl 3-anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carbothioate,
tert-butyl 2-(2-aminopyridin-4-yl)-4-oxo-3-(pyridin-2-ylamino)-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
tert-butyl 2-(2-acetamidopyridin-4-yl)-4-oxo-3-(pyridin-2-ylamino)-1,4,5,7-tetrahydro-6H-pyrolo[2,3-c]pyridine-6-carboxylate,
N-(4-(3-[(4-fluorophenyl)amino]-6-(methylsulfonyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)acetamide,
N-4-(6-acetyl-3-[(4-fluorophenyl)amino]-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)acetamide,
2-[2-(acetylamino)pyridin-4-yl]-3-[(4-fluorophenyl)amino]-N-methyl-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
methyl 2-[2-(acetylamino)pyridin-4-yl]-3-[(4-fluorophenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-(4-(3-[(4-fluorophenyl)amino]-6-(methylsulfamoyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)acetamide,
propan-2-yl 2-[2-(acetylamino)pyridin-4-yl]-3-[(4-fluorophenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
2-[2-(acetylamino)pyridin-4-yl]-N,N-dimethyl-3-[(4-methylphenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
N-4-(3-[(4-methylphenyl)amino]-4-oxo-6-(propan-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)acetamide,
N-(4-(6-acetyl-3-[(4-methylphenyl)amino]-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)acetamide,
2-[2-(acetylamino)pyridin-4-yl]-N-methyl-3-[(4-methylphenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxamide,
methyl 2-[2-(acetylamino)pyridin-4-yl]-3-[(4-methylphenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate,
N-(4-(3-[(4-methylphenyl)amino]-6-(methylsulfamoyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)acetamide,
propan-2-yl 2-[2-(acetylamino)pyridin-4-yl]-3-[(4-methylphenyl)amino]-4-oxo-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine-6-carboxylate
or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said
N-oxide, tautomer or stereoisomer.

One special aspect of the invention is intermediate (1-2),

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whereby A, E and Z have the meaning according to any of claims 1 to 5 or as defined in the aspects and embodiments described herein.

One special aspect of the invention is intermediate (I-h),

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whereby R¹, E and Z have the meaning according to any of claims 1 to 5 or as defined in the aspects and embodiments described herein, and LG represents a leaving group, such as, Cl, Br, I, aryl sulfonates, such as p-toluene sulfonate, or alkyl sulfonates, such as methane sulfonate or trifluoromethane sulfonate.

Another aspect of the invention relates to any of the intermediates described herein and to their use for preparing a compound of formula (I) as defined herein or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.