Claims
- 1. A heteroaromatic amine derivative of formula ##STR14## wherein A is a carbonyl or thiocarbonyl group;
- B is a methylene group;
- E is a straight-chained C.sub.2 -C.sub.4 alkylene group, which can be substituted by a C.sub.1 -C.sub.3 alkyl group;
- G is a straight-chained C.sub.1 -C.sub.6 alkylene group; which can be substituted by a C.sub.1 -C.sub.3 alkyl group;
- R.sub.1 and R.sub.2, which may be identical or different, are hydrogen atoms, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy groups;
- R.sub.3 is a hydrogen atom, a C.sub.3 -C.sub.5 alkenyl group, an alkyl or phenylalkyl group, wherein the alkyl moiety may contain from 1 to 3 carbon atoms;
- n is 0 and
- Het is a benzo[b]thienyl group, whilst the carbon structure of the above-mentioned homocyclic or heteroaromatic ring may be mono- or disubstituted by a halogen atom or by an alkyl, hydroxy, alkoxy, phenylalkoxy, phenyl, dimethoxyphenyl, nitro, amino, acetylamino, carbamoylamino, N-alkyl-carbamoylamino, hydroxymethyl, mercapto, alkylmercapto, alkylsulphinyl, alkylsulphonyl, alkylsulphonyloxy, alkylsulphonylamino, alkoxycarbonylmethoxy, carboxymethoxy or alkoxymethyl group or may be substituted by a methylenedioxy or ethylenedioxy group, whereby the above-mentioned alkyl moieties may each contain from 1 to 3 carbon atoms; or
- n is 0 or 1, and
- Het is a thienyl group, whilst the carbon structure of the above-mentioned heteroaromatic ring may be mono- or disubstituted by a halogen atom or by an alkyl, hydroxy, alkoxy, phenylalkoxy, phenyl, dimethoxyphenyl, nitro, amino, acetylamino, carbamoylamino, N-alkyl-carbamoylamino, hydroxymethyl, mercapto, alkylmercapto, alkylsulphinyl, alkylsulphonyl, alkylsulphonyloxy, alkylsulphonylamino, alkyoxycarbonylmethoxy, carboxymethoxy or alkoxymethyl group or may be substituted by a methylenedioxy or ethylenedioxy group, whereby the above-mentioned alkyl moieties may each contain from 1 to 3 carbon atoms;
- and the N-oxide, the enantiomer, diastereomer or acid addition salt thereof.
- 2. The physiologically acceptable acid addition salt of the compound as recited in claim 1.
- 3. A heteroaromatic amine derivative of formula ##STR15## wherein A is a carbonyl or thiocarbonyl group;
- B is a methylene group;
- E is an n-propylene group;
- G is a methylene, ethylene, n-propylene, n-butylene or n-pentylene group;
- R.sub.1 and R.sub.2, which may be identical or different, are hydrogen atoms, methyl or methoxy groups;
- R.sub.3 is a hydrogen atom, a methyl or allyl group;
- n is 0, and
- Het is a benzo[b]thien-2-yl, benzo[b]thien-3-yl, 6-hydroxybenzo[b]thien-3-yl, 6-methoxy-benzo[b]thien-3-yl, 5,6-dimethoxy-benzo[b]thien-3-yl, 2,5-dimethyl-benzo[b]thien-3-yl, 5-methoxy-benzo[b]thien-2-yl, 6-methoxy-benzo[b]thien-2-yl, 6-methylmercapto-benzo[b]thien-3-yl, 6-methylsulphinyl-benzo-[b]thien-3-yl, 6-methylsulphonyl-benzo[b]thien-3-yl, 6-methylsulphonyloxy-benzo[b]thien-3-yl, 6-ethoxycarbonylmethoxy-benzo[b]thien-3-yl, 6-carboxymethoxy-benzo[b]thien-3-yl, 6-dimethylamino-benzo[b]thien-3-yl, 6-methylsulphonylamino-benzo[b]thien-3-yl, 6-acetamino-benzo[b]thien-3-yl or benzo[b]-thien-4-yl group; or
- n is 0 or 1, and
- Het is a thien-2-yl, thien-3-yl, 5-methyl-thien-2-yl, 2-methyl-thien-3-yl, 3-methyl-thien-2-yl or 2,5-dimethyl-thien-3-yl group;
- the enantiomer, diastereomer or acid addition salt thereof.
- 4. The heteroaromatic amine derivative as recited in claim 3 wherein
- R.sub.1 and R.sub.2, which may be identical or different, are methyl or methoxy groups;
- R.sub.3 is a hydrogen atom or a methyl group;
- n is 0, and
- Het is a benzo[b]thien-2-yl or benzo[b]thien-3-yl group; or
- n is 0 or 1, and
- Het is a thien-2-yl or thien-3-yl group;
- the enantiomer, diastereomer or acid addition salt thereof.
- 5. The physiologically acceptable acid addition salt of the compound as recited in claim 3.
- 6. The physiologically acceptable acid addition salt of the compound as recited in claim 4.
- 7. 2-[N-Methyl-N-(2-thien-3-yl)-ethyl)-3-amino-propyl]-5,6-dimethoxy-1,3-dihydro-1-oxo-isoindole or the acid addition salt thereof.
- 8. The physiologically acceptable acid addition salt of the compound as recited in claim 7.
- 9. 2-[N-Methyl-N-(2-benzo[b]thien-3-yl)-3-amino-propyl]-5,6-dimethoxy-1,3-dihydro-1-oxo-isoindole or the acid addition salt thereof.
- 10. The physiologically acceptable acid addition salt of the compound as recited in claim 9.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3640641 |
Nov 1986 |
DEX |
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Parent Case Info
This is a continuation of application Ser. No. 627,514, now abandoned, filed Dec. 14, 1990, which is a continuation of application Ser. No. 455,722, now abandoned filed Dec. 22, 1989.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3919202 |
Diana |
Nov 1975 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
0129461 |
Jun 1983 |
EPX |
Continuations (2)
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Number |
Date |
Country |
Parent |
627514 |
Dec 1990 |
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Parent |
455722 |
Dec 1989 |
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