Heterobicyclic amide compounds

Abstract

Compounds of formula I

Description

Claims

1. A compound of formula I

2. The compound of formula I according to claim 1 as illustrated in formula Ia

3. The compound of formula I according to claim 1 as illustrated in formula Ib

4. The compound of formula I according to claim 1 as illustrated in formula Ic

5. The compound of formula I according to claim 1 selected from

6. A process for the production of a compound of formula I

7. The compound of claim 1 wherein R9 is 1H-pyrrolo[2,3-c]pyridin-7-yl which is unsubstituted or substituted by one or two substituents selected from halogen, C1-C6alkyl, halogen-C1-C6alkyl and C(O)OCH3.

8. The compound of claim 1 wherein R9 is 1H-pyrazolo[3,4-c]pyridin-7-yl which is unsubstituted or substituted by one or two substituents selected from halogen, C1-C6alkyl, halogen-C1-C6alkyl and C(O)OCH3.

9. The compound of claim 2, wherein X is C—H.

10. The compound of claim 2, wherein X is N

11. The compound of claim 3, wherein X is C—H.

12. The compound of claim 3, wherein X is N.

13. The compound of claim 4, wherein X is C—H.

14. The compound of claim 4, wherein X is N.

15. The compound of claim 7, wherein R9 is 1H-pyrrolo[2,3-c]pyridin-7-yl which is unsubstituted.

16. The compound of claim 8, wherein R9 is 1H-pyrazolo[3,4-c]pyridin-7-yl which is unsubstituted.

17. The compound of claim 7, wherein R9 is 1H-pyrrolo[2,3-c]pyridin-7-yl which is substituted by one of methyl, chloro, fluoro, or trifluoromethyl.

18. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier or adjuvant or mixtures thereof.

19. A pharmaceutical composition comprising a compound according to claim 5 and a pharmaceutically acceptable carrier or adjuvant or mixtures thereof.