Claims
- 1. A compound of the formula: ##STR29## a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein:
- R.sup.1 and R.sup.2 each independently are halo or methyl;
- R.sup.3 is hydrogen, halo, nitro or trifluoromethyl;
- R.sup.4 is
- trifluoromethyl or methyl carbonyl; or
- a radical --C(.dbd.X)--NR.sup.5 R.sup.6 wherein X is O or S, and R.sup.5 and R.sup.6 each independently are hydrogen or C.sub.1-4 alkyl; or
- a radical -Alk-R.sup.7, wherein Alk is C.sub.1-4 alkanediyl; and
- R.sup.7 is hydrogen or hydroxy; and
- Het is a heterocyclic radical of the formula: ##STR30## wherein: R.sup.14 and R.sup.15 taken together form C.sub.3-4 alkanediyl, and
- R.sup.13 is hydrogen or hydroxy, wherein in the heterocyclic radical (d), a nitrogen atom can optionally be oxidized,
- PROVIDED THAT when the heterocyclic radical (d) is a 5,6,7,8-tetrahydro-4-quinolinyl group, R.sup.13 is hydroxy.
- 2. A compound according to claim 1 wherein R.sup.4 is a radical C(C.dbd.O)NH.sub.2 or methyl, and Het is 2-hydroxy-6,7-dihydro-5H-1-pyrindinyl.
- 3. A compound according to claim 2 wherein the compound is selected from the group consisting of:
- 3-[[1-(2,6-dichlorophenyl)ethyl]amino]-6,7-dihydro-5H-1-pyrindine-2-ol;
- pharmaceutically acceptable salt forms thereof; and
- stereochemically isomeric forms thereof.
- 4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and as an active ingredient a therapeutically effective amount of a compound as defined in claim 1.
- 5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and as an active ingredient a therapeutically effective amount of a compound as defined in claim 2.
- 6. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and as an active ingredient a therapeutically effective amount of a compound as defined in claim 3.
Priority Claims (1)
Number |
Date |
Country |
Kind |
91203431 |
Dec 1991 |
EPX |
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a divisional of application Ser. No. 08/240,737, filed May 12, 1994, now U.S. Pat. No. 5,480,997 is of PCT Application No. PCT/EP 92/02993, filed Dec. 22, 1992, published as WO93/13069, Jul. 8, 1993, which claims priority from EPO application Serial No. 91,203.431.1, filed Dec. 30, 1991.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4246429 |
Janssen et al. |
Jan 1981 |
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5480997 |
Janssen et al. |
Jan 1996 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
240737 |
May 1994 |
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