Chemical Abstracts, Columbus, OH, vol. 123, No. 15, Oct. 9, 1995 XP-002127159, JP 06-256317. |
Spencer, Wandless, Schreiber, Crabtree Controlling Signal Transduction with Synthetic Ligands, Science, vol. 262, Nov. 12, 1993, pp. 1019-1024. |
Keenan, Yaeger, Courage, Rollins, Pavone, Rivera, Yang, Guo, Amara, Clackson, Gilman, Holt—Ariad Gene Therapeutics, Cambridge, MA Synthesis and Activity of Bilalent FKBP12 Ligands for the Regulated Dimerization of Proteins Bioorganics & Medicinal Chemistry 6 (1998) pp. 1309-1335. |
Marshall, Schlaf, Csernansky—Dept. Of Chemistry, Northwestern Univ., Evanston, IL A Convenient Synthesis of Diketopiperazines via Aminolysis of N-Pyruvyl α-Amino Esters Synthetic Communications, 5(3), (1975) pp. 237-244. |
Kim, Kim—Dept. Of Chemistry, Korea Advanced Inst. of Science and Technology, Taejon, Korea Highly Stereoselective Allylation to Chiral α-Keto Amides Derived From (S)-Indoline-2-carboxylic Acid, Asymmetric Synthesis of Functionalized Tertiary Homoallyl Alcohols Tetrahedron Letters, vol. 36, No. 38, pp. 6895-6898, 1995, Elsevier Science Ltd. |
Slee, Laslo, Elder, Ollmann, Gustchina, Kervinen, Zdanov, Wlodawer, Wong Selectivity in the Inhibition of HIV and FIV Protease: Inhibitory and Mechanistic Studies of Pyrrolidine-Containing α-Keto Amide and Hydroxyethylamine Core Structures J. Am. Chem. Soc 1995, 117, pp. 11867-11878. |
Ottenheijm, Herscheid, Kerkhoff, Spande—Dept. Or Organic Chemistry, Catholic Univ. Of Nijmegen, The Netherlands Approaches to Analogues of Dehydrogliotoxin. An Efficient Synthesis of a Gliotoxin Analogue with Anti-Reverse Transcriptease Activity J. Org. Chem., vol. 41, No. 21, 1976, pp. 3433-3438. |
Ottenheijm, Kerkoff, Bejen—Dept. Or Organic Chemistry, Univ. Of Jijmegen, The Netherlands A Three-step Synthesis of a Gliotoxin Analogue with Anti-reverse Transcriptase Activity J.C.S. Chem. Comm. 1975, pp. 768-769. |
Shuker, Hajduk, Meadows, Fesik Discovering High-Affinity Ligands for Proteins: SAR by NMR Science, vol. 274, Nov. 29, 1996, pp. 1531-1534. |
Wang, Lane, Resik, Petros, Luly, Krafft—Abbott Laboratories Synthesis and FKBP Binding of Small Molecule Mimics of the Tricarbonyl Region of FK506 Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 9, pp. 1161-1166. |
Stocks, Birkinshaw, Teague—Fisons Pharmaceuticals The Contribution to Binding of the Pyranoside Substituents in the Excised Binding Domain of FK-506 Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 12, pp. 1457-1460. |
Teague, Stocks—Fisons Pharmaceuticals The Affinity of the Excised Binding Domain of FK-506 for the Immunophilin FKBP12 Bioorganic & Medicinal Chemistry Letters, vol. 3, No. 10, pp. 1947-1950. |
Wakamiya, Konishi, Chaki, Teshima, Shiba—Dept. Of Chemistry, Osaka Univ., Japan Chemical Studies on Tuberactinomycin, XIII. Synthesis of DL-Dihydroviomycidine and DL-Viomycidine Heterocycles, vol. 15, No. 2, 1981, pp. 999-1005. |
Nadir, Arora—Dept. of Chemistry, Indian Inst. of Technology, Delhi, India Reaction of N-arylsulfonylaziridines with Dimethylsulfonium-ethoxycarbonly Methylide: Regio-and Stereo-selective Synthesis of 1-arylsulfonyl-2-ethoxycarbonyl Azetidines J. Chem. Soc., Perkin Trans. 1995, pp. 2605-2609. |
Moree, van der Marel, Liskamp-—Dept. of Organic Chemistry, Gorlaeus Laboratories, The Netherlands Synthesis of Peptidosulfinamides and Peptodosulfonamides: Peptidomimetics Containing the Sulfinamide or Sulfonamide Transition-State Isostere J. Org. Chem. 1995, 60, pp. 5157-5169. |
Armistead, Badia, Deininger, Duffy, Saunders, Tung, Thomson, DeCenzo, Futer, Livingston, Murcko, Yamashita, Navia—Vertex Pharmaceuticals Inc., Cambridge, MA Design, Synthesis and Struucture of Non-macrocyclic Inhibitors of FKBP12, the Major Binding Protein for the Immunosuppressant FK506 Acta Cryst. (1995) D51, pp. 522-528. |
Yamashia, Oh, Yen, Bossard, Berandt, Levy, Newman-Tarr, Badger, Luengo, Holt—SmithKline Beecham Pharmaceuticals, King of Prussia, PA Design, Synthesis and Evaluation of Dual Domain FKPB Ligands Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 2, pp. 325-328, 1994. |
Luengo, Konialian-Beck, Levy, Brandt, Eggleston, Holt—SmithKline Beecham Pharmaceuticals, King of Prussia, PA Synthesis and Structure-Activity Relationships of Macrocyclic FKBPLigands Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 2, pp. 321-324, 1994. |
Hauske, Dorff, Julin, DiBrino, Spencer, Williams—Pfizer, Inc.—Design and Synthesis of Novel FKBP Inhibitors J. Med. Chem. 1992, 35, pp. 4284-4296. |
Hamilton, Huang, Connolly, Ross, Guo, Valentine, Suzdak, Steiner—Guilford Pharmaceuticals, Inc. FKPB12-Binding Domain Analogues of FK506 Are Potent, Nonimmunosuppressive Neurotrophic Agents In Vitro and Promote Recovery in a Mouse Model of Parkinson's Disease Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 13, pp. 1783-1790, 1997. |
Andrus, Schreiber—Dept. of Chemistry, Harvard Univ., Cambridge, MA Structure-Based Design of an Acycllic Ligand That Bridges FKBP12 and Calcineurin J. Am. Chem. Soc., 1993, 115, pp. 10420-10421. |
Babine, Bleckman, Littlefield, Parge, Pellitier, Lewis, French, Imbacuan, Katoh, Tatlock, Showalter, Villafranca—Agouron Pharmaceuticals, Inc., San Diego, CA Design, Synthesis and X-Ray Crystallographic Studies of [7.3.1] and [8.3.1] Macrocyclic FKPB012 Ligands Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 4, pp. 385-390 1996. |
Drogovich, Barker, French, Imbacuan, Kalish, Kissinger, Knighton, Lewis, Moomaw Parge, Pelletier, Prins, Showwalter, Tatlock, Tucker, Villafranca—Agouraon Pharmaceuticals, Inc., San Diego, CA Structure-Based Design of Novel, Urea-Containgin FKBP 12 Inhibitors J. Med. Chem., 1996, 39, pp. 1872-1884. |
Babine, Bleckman, Kissinger, Showalter, Pelletier, Lewis, Tucker, Moomaw, Parge, Villafranca—Agouraon Pharmaceuticals, Inc., San Diego, CA Design, Synthesis and X-Ray Crystallographic Studies of Novel FKPB-12 Ligands Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 15, pp. 1719-1724, 1995. |
Andres, Macdonald—Dept. of Chemistry, Univ. of Virginia, Charlotteville, VA—Ocain, Longhi, Wyeth-Averat Reserach Conformationally Defined Analogs of Prolylamides. Trans-Prolyl Peptidomimetics J. Org. Chem. 1993, 58, pp. 6609-6613. |
Tatlock, Kouish, Parge, Knighton, Showalter, Lewis, French, Villafranca—Agouraon Pharmaceuticals, Inc., San Diego, CA High-Affinity FKBP12 Ligands Derived from (R)-(−)-Carvone. Synthesis and Evaluation of FK50-6 Pyranose Ring Replacements Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 21, pp. 2489-2494, 1995. |
Holt, Konialian-Beck, Oh, Yen, Rozamus, Krog, Erhard, Ortiz, Levy, Brandt, Bossard, Luengo—SmithKline Beecham Pharmaceuticals, King of Prussia, PA Structure-Activity Studies of Synthetic FKPB Ligands as Peptidly-Prolyl Isomerase Inhibitors Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 2, pp. 315-320, 1994. |
Holt, Luengo, Yamashita, Oh, Konialian, Yen, Rozamus, Brandt, Bossard, Levy, Eggleston, Liang, Schultz, Stout, Clardy, SmithKline Beecham Pharmaceuticals, King of Prussia, PA Design, Synthesis and Kinetic Evlauation of High-Affinity FKBP Ligands and the X-Ray Crystal Structures of Their Complexes with FKBP12 J. Am. Chem. Soc., 1993, 115, pp. 9925-9938. |
Chemical Abstracts 121:224, abstract by Holt, Bioorg Med Chem Lett, 4(2), 315-320, 1994.* |
USPatFull2000:31444, abstract of Armistead, US Patent #6,037,370, 2000.* |
USPatfull 2000:15654, abstract of Steiner, #6022878, 2000.* |
Uspatfull 1999:167033, abstract of Steiner, #6004993, 1999.* |
Uspatfull 1999:151234, abstract of Hamilton, #5990131, 1999.* |
Uspatfull #1999:128588, abstract of Broder, #5968972, 1999. |
USPatFull 1999:106615, abstract of Arzeno, #5948939, 1999. |
USPatFull 1999:102830, abstract of steiner, #5,945,441, 1999. |
USPatFull 1999:92670, abstract of Armistead, #5,935,954, 1999. |
USPatFull 1998:154288, abstract of Steiner, #5,846,981, 1998.* |
USPatFull 1998:115749, abstract os Zelle, #5,811,434, 1998.* |
USPatFull 1998:104767, abstract of Steiner, #5,801,197, 1998.* |
USPatFull 1998:101646, abstract of Steiner, #5,798,355, 1998.* |
USPatFull 1998:88862, abstract of Hamilton, #5,786,378, 1998.* |
Chemical Abstracts 127:81793, abstract of Wong, WO 9721100, 1997. |