Claims
- 1. A compound represented by the formula: ##STR16## or represented by the formula: ##STR17## wherein: m is an integer from two to four;
- n is an integer from two to four;
- Z is --C(O)R.sup.1 in which R.sup.1 is hydrogen, or alkyl having seven or more carbon atoms;
- Z.sup.1 is hydrogen or --C(O)R.sup.9, where R.sup.9 is lower alkyl or aryl; and
- Y.sup.1 is lower alkylene of four to six carbon atoms, or lower alkylene of three to five carbon atoms plus one member that is --O--, --S--, or >N--R.sup.10,
- where R.sup.10 is hydrogen or alkyl of one to five carbon atoms;
- or a pharmaceutically acceptable salt thereof;
- provided that that when when m is two, Y.sup.1 is not --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --.
- 2. The compound of claim 1 wherein Z.sup.1 is hydrogen.
- 3. The compound of claim 1 wherein Y is --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --.
- 4. The compound of claim 3 wherein Z.sup.1 is hydrogen.
- 5. The compound of claim 1 wherein m is two.
- 6. The compound of claim 5 wherein Z.sup.1 is hydrogen.
- 7. A pharmaceutical composition comprising a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound of claim 1.
- 8. A pharmaceutical composition comprising a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound of claim 2.
Parent Case Info
This is a division of pending application Ser. No. 008,909, filed Jan. 30, 1987, incorporated herein by reference.
Non-Patent Literature Citations (2)
Entry |
"Antitumor Activity of Derivatives of Mycophenolic acid", Suzuki et al., J. Antibiotics, 29(3), 275-285, 1975. |
"Antitumor and Immunosuppressive Effects of Mycophenolic Acid", Ohsugi et al., Cancer Research, 36, 2923-2927, 1976. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
8909 |
Jan 1987 |
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