Claims
- 1. A compound represented by the formula: ##STR16## wherein: m is an integer from two to four;
- Z is selected from Formulae (a) (b) or (c), as follows:
- (a) ##STR17## in which: R.sup.4 is hydrogen, alkyl, aryl, or --NR.sup.2 R.sup.3 ; where R.sup.2 is hydrogen or lower alkyl, and
- R.sup.3 is hydrogen, lower alkyl, --phenyl--CO.sub.2 R.sup.2 or a pharmaceutically acceptable cation;
- (b) ##STR18## in which: n is an integer from zero to six, and
- R.sup.5 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation;
- (c) ##STR19## in which: R.sup.6 and R.sup.7 are independently hydrogen or --CO.sub.2 R.sup.5 ; and
- Y is lower alkylene for four to six carbon atoms, or lower alkylene of three to five carbon atoms plus one member that is --O--, --S--, or ##STR20## where R.sup.8 is hydrogen or alkyl of one to five carbon atoms; or a pharmaceutically acceptable salt thereof.
- 2. The compound of claim 1 wherein Y is --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --.
- 3. The compound of claim 1 wherein m is 2.
- 4. The compound of claim 2 wherein m is 2.
- 5. The compound of claim 4 where Z is selected from Formula (b), R.sup.5 is methyl, and n is 2.
- 6. The compound of claim 4 where Z is selected from Formula (b), R.sup.5 is ethyl, and n is 2.
- 7. The compound of claim 2 where Z is selected from Formula (b), R.sup.5 is methyl, and n is 2.
- 8. The compound of claim 2 where Z is selected from Formula (b), R.sup.5 is ethyl, and n is 2.
- 9. The compound of claim 1 where Z is selected from Formula (b), R.sup.5 is methyl, and n is 2.
- 10. The compound of claim 1 where Z is selected from Formula (b), R.sup.5 is ethyl, and n is 2.
- 11. A pharmaceutical composition comprising a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound of claim 1.
Parent Case Info
This is a division of pending application Ser. No. 099,950, filed Sept. 23, 1987 now U.S. Pat. No. 4,748,173, which is a division of application Ser. No. 008,909, filed Jan. 30, 1987, now U.S. Pat. No. 4,727,069, issued Feb. 23, 1988.
Non-Patent Literature Citations (1)
Entry |
"Antitumor Activity of Derivatives of Mycophenolic Acid", Suzuki et al., J. Antibiotics, 29(3), 275-285, 1975. |
Divisions (2)
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Number |
Date |
Country |
Parent |
99950 |
Sep 1987 |
|
Parent |
8909 |
Jan 1987 |
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