Claims
- 1. A compound of the formula ##STR105## wherein Het is ##STR106## n is 1, 2, 3 or 4; X is a direct single bond or --CH.sub.2 --;
- R.sub.1 is hydrogen or acyl;
- R.sub.4 is hydrogen, methyl or ethyl;
- R.sub.5 and R.sub.6 are each independently hydrogen or methyl;
- R.sub.10 is hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or pyridyl; and
- R.sub.11 and R.sub.12 are each independently hydrogen, methyl, chlorine or methoxy; or
- R.sub.11 and R.sub.12, together with each other, are methylenedioxy;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 2. A compound of claim 1,
- where
- Het is ##STR107## n is 1, 2, 3 or 4; X is a direct single bond or --CH.sub.2 --;
- R.sub.1 and R.sub.4 are hydrogen; and
- R.sub.5, R.sub.6 and R.sub.10 are each independently hydrogen or methyl; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 3. A compound of claim 1, where n is 2 or 3.
- 4. A compound of claim 2, where n is 2 or 3.
- 5. An antispasmodic or antiallergic pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective antispasmodic or antiallergic amount of a compound of claim 1.
- 6. The method of relieving spasmodic activity in a warm-blooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective antispasmodic amount of a compound of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2833140 |
Jul 1978 |
DEX |
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Parent Case Info
This is a division of copending application Ser. No. 443,912, filed Nov. 23, 1982, now U.S. Pat. No. 4,581,367, which in turn is a division of application Ser. No. 285,713, filed July 22, 1981, now U.S. Pat. No. 4,378,361, issued Mar. 29, 1983; which which in turn is a continuation of application Ser. No. 156,928, filed June 6, 1980, now abandoned; which in turn is a continuation of application Ser. No. 060,389, filed July 25, 1979, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3274194 |
Hayao |
Sep 1966 |
|
3718648 |
Beyerle et al. |
Feb 1973 |
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Divisions (2)
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Number |
Date |
Country |
Parent |
443912 |
Nov 1982 |
|
Parent |
285713 |
Jul 1981 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
156928 |
Jun 1980 |
|
Parent |
60389 |
Jul 1979 |
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